CN106729148A - 一种治疗脱肛的中药组合物 - Google Patents

一种治疗脱肛的中药组合物 Download PDF

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CN106729148A
CN106729148A CN201710001043.5A CN201710001043A CN106729148A CN 106729148 A CN106729148 A CN 106729148A CN 201710001043 A CN201710001043 A CN 201710001043A CN 106729148 A CN106729148 A CN 106729148A
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张先军
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Abstract

本发明公开了一种治疗脱肛的中药组合物。其中药原料及重量份配比为：黄芪30‑50份，人参5‑15份，当归10‑30份，橘皮5‑15份，升麻5‑15份，柴胡5‑15份，白术10‑20份，黄芩10‑20份，石榴皮10‑20份，黄精10‑20份，薏苡仁20‑40份，仙鹤草20‑40份，地榆10‑20份，桑椹10‑20份，玉竹10‑20份，两面针10‑20份，马齿苋10‑20份，金银花10‑30份，蒲公英10‑30份，灸甘草5‑15份。本发明中药组合物具有补中益气、升阳举陷的功效，其配伍科学，疗效显著，作用可靠，无副作用。

Description

一种治疗脱肛的中药组合物
技术领域
本发明属于中药技术领域，具体涉及一种治疗脱肛的中药组合物。
背景技术
脱肛又称直肠脱垂，是指直肠壁部分或全层向下移位。直肠壁部分下移，即直肠黏膜下移，称黏膜脱垂或不完全脱垂；直肠壁全层下移称完全脱垂。若下移的直肠壁在肛管直肠腔内称内脱垂；下移到肛门外称为外脱垂。目前，临床上治疗脱肛多将硬化剂注射到脱垂部位的黏膜下层内，使黏膜与肌层产生无菌性炎症，粘连固定。硬化剂注对儿童与老人疗效尚好，但对于成年人容易复发。
发明内容
为了克服现有技术中采用硬化剂注射治疗脱肛存在易复发的不足，本发明提供一种配伍科学、疗效显著、作用可靠、无副作用的治疗脱肛的中药组合物。
本发明解决技术问题所采用的技术方案为：一种治疗脱肛的中药组合物，其特征在于：其中药原料及重量份配比为：黄芪30-50份，人参5-15份，当归10-30份，橘皮5-15份，升麻5-15份，柴胡5-15份，白术10-20份，黄芩10-20份，石榴皮10-20份，黄精10-20份，薏苡仁20-40份，仙鹤草20-40份，地榆10-20份，桑椹10-20份，玉竹10-20份，两面针10-20份，马齿苋10-20份，金银花10-30份，蒲公英10-30份，灸甘草5-15份。
本发明的优选技术方案是：一种治疗脱肛的中药组合物，其特征在于：其中药原料及重量份配比为：黄芪40份，人参10份，当归20份，橘皮10份，升麻10份，柴胡10份，白术15份，黄芩15份，石榴皮15份，黄精15份，薏苡仁30份，仙鹤草30份，地榆15份，桑椹15份，玉竹15份，两面针15份，马齿苋15份，金银花20份，蒲公英20份，灸甘草10份。
脱肛是由于气血虚弱，中气下陷，不能固摄，以致肛管直肠向下脱出。年老体弱，气血双亏；劳倦过度，久病体虚，久泻久痢，大肠虚冷等症状，均可导致气血虚弱，中气下陷，失于固摄，以致肛管直肠向下脱出不能回纳。治则当补中益气，升阳举陷，清热解毒，活血止痛。本发明的中药组合物中，黄芪味甘微温，入脾、肺经，补中益气，升阳固表，为君药。人参、灸甘草、白术补气健脾为臣药，与黄芪合用，以增强共补益中气之功。血为气之母，气虚时久，营血亦亏，故佐以当归养血和营，协人参、黄芪以补气养血；橘皮理气和胃，使诸药补而不滞，黄芩、黄精、玉竹、桑椹四药滋阴生津，清热燥湿；石榴皮、薏苡仁、仙鹤草、两面针、马齿苋、金银花、蒲公英七味药清热解毒，利水消肿；地榆止血祛瘀；少量升麻、柴胡升阳举陷，协助君药以升提下陷之中气。灸甘草调和诸药，为使药。纵观全方，诸药合用，使气虚得补，气陷得升则诸症自愈。
本发明所提供的中药组合物配伍科学，本发明的中药组合物按常规的水煎法制取药剂服用。经临床应用验证，其疗效显著，作用可靠，药性平和，未出现毒副作用，总有效率92%，治愈率达76%。
具体实施方式
下面结合实施例对本发明做进一步说明。
实施例1
一种治疗脱肛的中药组合物，其中药原料及重量配比为：黄芪40g，人参10g，当归20g，橘皮10g，升麻10g，柴胡10g，白术15g，黄芩15g，石榴皮15g，黄精15g，薏苡仁30g，仙鹤草30g，地榆15g，桑椹15g，玉竹15g，两面针15g，马齿苋15g，金银花20g，蒲公英20g，灸甘草10g。
实施例2
一种治疗脱肛的中药组合物，其中药原料及重量配比为：黄芪30g，人参15g，当归10g，橘皮15g，升麻5g，柴胡15g，白术10g，黄芩20g，石榴皮10g，黄精20g，薏苡仁20g，仙鹤草40g，地榆10g，桑椹20g，玉竹10g，两面针20g，马齿苋10g，金银花30g，蒲公英10g，灸甘草15g。
实施例3
一种治疗脱肛的中药组合物，其中药原料及重量配比为：黄芪50g，人参5g，当归30g，橘皮5g，升麻15g，柴胡5g，白术20g，黄芩10g，石榴皮20g，黄精10g，薏苡仁40g，仙鹤草20g，地榆20g，桑椹10g，玉竹20g，两面针10g，马齿苋20g，金银花10g，蒲公英30g，灸甘草5g。
实施例4
一种治疗脱肛的中药组合物，其中药原料及重量配比为：黄芪35g，人参13g，当归15g，橘皮13g，升麻8g，柴胡13g，白术12g，黄芩18g，石榴皮12g，黄精18g，薏苡仁25g，仙鹤草35g，地榆12g，桑椹18g，玉竹12g，两面针18g，马齿苋12g，金银花25g，蒲公英15g，灸甘草13g。
实施例5
一种治疗脱肛的中药组合物，其中药原料及重量配比为：黄芪45g，人参8g，当归25g，橘皮8g，升麻13g，柴胡8g，白术18g，黄芩12g，石榴皮18g，黄精12g，薏苡仁35g，仙鹤草25g，地榆18g，桑椹12g，玉竹18g，两面针12g，马齿苋18g，金银花15g，蒲公英25g，灸甘草8g。
下面结合本发明的中药组合物，在本人所处医院进行临床疗效实验如下：
1、临床病例选择：挑选50例脱肛患者，年龄5-80岁。
2、诊断标准：
a) 多见于排便或努挣时，直肠粘膜脱出，色淡红，长度小于4cm，质软，不出血，便后能自行回纳，肛门功能良好者，为不完全性脱垂；
b)排便或腹压增加时。直肠全层脱出，色红，长度在4～8cm，圆锥形，质软，表面为环状有层次的粘膜皱襞；便后需手法复位，肛门括约功能下降，为完全性脱垂；
c) 排便或增加腹压时，直肠全层或部分乙状结肠脱出，长度大于8cmi，圆柱形，丧面有较浅的环状皱襞，触之很厚，需手法复位，肛门松驰，括约功能明显下降，为重度脱垂。
3、实验方法：将上述患者随机分为实验治疗组及对照治疗组两组，每组25人，其中，实验治疗组采用本发明实施例一提供的中药组合物，其是将本发明提供的中药原料按照传统水煎法煎煮两遍取汁约400ml，分早、晚两次温热服用，一天一剂，七天一疗程。对照治疗组采用：注射5%石炭酸植物油、5%盐酸奎宁尿素水溶液到脱垂部位的黏膜下层内。
4、疗效标准：
a)治愈：症状及体征消失，肛门括约功能良好；
b)好转：症状及体征改善；
c)未愈：症状及体征均无变化。
5、实验结果：
实验治疗组：治疗2-7个疗程，治愈19例，有效4例，无效2例。经不良反应（ADR）安全性评价，治疗期间未发生毒副作用。
对照治疗组：治疗一周至治疗二周后，累计脱肛治愈22例，但治疗3－4个月后有5例患者脱肛。
通过对比，针对脱肛的治疗，西药对照治疗组虽然治疗速度快，但易复发。本发明提供的实验治疗组对脱肛治疗效果更为彻底。
6、典型病例：
病例一：刘某，男，76岁。患者自述因便秘导致脱肛2cm，需手动复位，偶尔憋气会导致再次脱肛。服用本发明的中药组合物制备的药剂3个疗程后，憋气、大便未出现脱肛，疼痛消失；继续服用2个疗程，各症状消失，治愈。
病例二：赵某，女，12岁。患者自述憋气或者用力大便后，肛门脱落后会自动复位。服本发明的中药组合物制备的药剂2个疗程后，未再出现脱肛现象；巩固服用1个疗程后，即使可以憋气也未再出现脱肛现象，治愈。
中药原料用量与组分同样重要，因此用量必须得当。本发明用于临床实验的各中药原料用量是本发明的最佳用量，其适用范围广。其中，黄芪40g，用量多，补中益气，升阳固表，本症主要因为中气不足而脱肛，因此大量应用黄芪以补中气。当归20g，用量大，血为气之母，气虚时久，营血亦亏，故佐以当归养血和营，协人参10g、黄芪以补气养血。升麻10g，柴胡10g，少量应用，升阳举陷，协助君药以升提下陷之中气。

Claims (2)

1.一种治疗脱肛的中药组合物，其特征在于：其中药原料及重量份配比为：黄芪30-50份，人参5-15份，当归10-30份，橘皮5-15份，升麻5-15份，柴胡5-15份，白术10-20份，黄芩10-20份，石榴皮10-20份，黄精10-20份，薏苡仁20-40份，仙鹤草20-40份，地榆10-20份，桑椹10-20份，玉竹10-20份，两面针10-20份，马齿苋10-20份，金银花10-30份，蒲公英10-30份，灸甘草5-15份。
2.根据权利要求1所述的一种治疗脱肛的中药组合物，其特征在于：其中药原料及重量份配比为：黄芪40份，人参10份，当归20份，橘皮10份，升麻10份，柴胡10份，白术15份，黄芩15份，石榴皮15份，黄精15份，薏苡仁30份，仙鹤草30份，地榆15份，桑椹15份，玉竹15份，两面针15份，马齿苋15份，金银花20份，蒲公英20份，灸甘草10份。
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