CN106728702A - 一种预防银屑病复发的药剂 - Google Patents

一种预防银屑病复发的药剂 Download PDF

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CN106728702A
CN106728702A CN201710122305.3A CN201710122305A CN106728702A CN 106728702 A CN106728702 A CN 106728702A CN 201710122305 A CN201710122305 A CN 201710122305A CN 106728702 A CN106728702 A CN 106728702A
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高增强
安红
高铭阳
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Abstract

本发明公开了一种预防银屑病复发的药剂，属于外用药物技术领域，该药剂包括组份A和组份B，所述组份A为吡硫翁锌气雾剂，所述组份B为生物提取物，将组份A与组份B按照重量比1∶2的比例充分混合即得本发明所述的预防银屑病复发的药剂。经临床试验证明，降低了银屑病复发率，且减少了毒副作用。

Description

一种预防银屑病复发的药剂
技术领域
本发明涉及药物技术领域，尤其涉及一种预防银屑病复发的药剂。
背景技术
银屑病作为一种慢性炎性皮肤病，复发性较强，至今病因和发病机制尚未完全清楚，主要是遗传因素和环境因素等多种因素相互作用的结果，病理变化表现为角质形成细胞异常增殖、异常分化、凋亡及局部炎症，进行期的银屑病细胞增殖及炎性反应异常活跃。寻常型银屑病可发于全身各处，常见于四肢伸侧，特别是肘部，膝部，初发为红色或棕红色的丘疹或斑丘疹，后逐渐扩展为边界清楚的棕红色斑片，可损害头皮，也可损害全身，严重影响患者的生活质量，近年来发病率呈逐年增加的趋势。目前采用喷雾疗法也是治疗银屑病主要方法之一，如采用吡硫翁锌气雾剂治疗，虽然效果较好，但易复发，往往也带来副作用，最常见的副作用如皮肤过敏，同样给患者带来痛苦。为解决吡硫翁锌气雾剂在使用中存在的问题，发明人在多年的临床治疗实践中，对吡硫翁锌气雾剂进行改进，以降低其毒副作用。经临床验证，取得了显著的治疗效果。
发明内容
本发明的目的是提供一种预防银屑病复发的药剂。
本发明的目的是通过以下技术方案实现的，该预防银屑病复发的药剂包括组份A和组份B，所述组份A为吡硫翁锌气雾剂，所述组份B为生物提取物。
所述生物提取物由血竭30g、皂荚80g、地肤子60g、土瓜狼毒65g、徐长卿45g、黄药子55g、花椒90g、白花蛇舌草90g、虎掌草77g、乳香44g、木鳖子54g、紫弹树160g、蝉蜕33g、菊花43g、白芥子120g粉碎混匀，加入10倍生物材料重量的蒸馏水浸泡40min后武火加热煮沸，沸腾后改用文火，保持微沸30min，搅拌，趁热过滤，再加适量蒸馏水同法煎煮20min滤过，合并滤液，水煎液经浓缩至400ml，加入95％乙醇，边加边搅拌，使杂质沉淀析出，放置24h滤过，滤液经水浴蒸发至无醇味，加蒸馏水定容至200ml制成，以60kPa，30min灭菌制成。
使用时，将组份A与组份B按照重量比1∶2的比例充分混合即得本发明所述的预防银屑病复发的药剂。
方中：血竭散瘀定通、止血生肌；皂荚祛风痰、除湿毒、杀虫；地肤子利小便、清湿热、主治小便不利带下、疝气风疹、疮毒疥癣，阴部湿痒；土瓜狼毒治胃气疼痛、食积结滞、消水肿、破血积、打虫积、打痰毒；徐长卿镇痛止咳、利水消肿、活血解毒；黄药子凉血降火、消瘿解毒；花椒温中散寒、除湿止痛、杀虫、解鱼腥毒；白花蛇舌草清热利湿、解毒；虎掌草清热解毒、活血舒筋；乳香调气活血、定痛追毒；木鳖子消肿散结、去毒；紫弹树清热解毒、祛痰、利小便；蝉蜕散风热、宣肺、治风疹瘙痒、麻疹透发不畅等；菊花疏风清热、明目解毒；白芥子利气豁痰、温中散寒、通络止痛。
临床资料
1一般资料：2009年6月～2013年7月间我院收治的120例银屑病患者，我们采用随机数字表法将其分为对照组、治疗组、中药组，每组40例；各组患者的临床表现及各项检查结果均符合银屑病的临床诊断标准。只使用组份A治疗的为对照组、使用本发明气雾剂治疗的为治疗组，单独服用本发明所述的组份B治疗的为中药组。各组在年龄、性别等一般资料比较无统计学意义，具有可比性。
2、治疗方法治疗组采用本发明所述的气雾剂对准患处喷雾治疗，对照组采用组份A对准患处喷雾治疗；中药组采用组份B对准患处喷雾治疗；三组均每次对准患处均匀喷湿为宜，每日3-6次；用药8周后观察疗效。
3、疗效评定标准显效：用药6-7周后，患者皮肤瘙痒、斑块、鳞屑等症状基本消失，皮损恢复正常的面积达90％以上。有效：用药6-8周后，患者皮肤瘙痒、斑块、鳞屑等症状明显改善，皮损恢复正常的面积达80％-90％。无效：用药8周后，患者皮肤瘙痒斑块、鳞屑等症状无任何改善，甚至加重。治疗的总有效率＝(显效+有效)/总例数×100％。
4、治疗结果如下表所示。
组别 例数 日喷次数 显效 有效 无效 副作用 复发率 总有效率
治疗组 40 3 32 8 0 0 0 100％
对照组 40 6 16 12 12 7 8 70％
中药组 40 6 12 12 16 2 7 60％
通过以上临床资料可知，治疗组虽然日喷次数较少，但是取得了理想的治疗效果，总有效率高于对照组和中药组，而且无副作用，无复发率。而对照组使用组份A治疗，有8例出现过敏现象。中药组有2例伴发痒痛症状。由此可知，治疗组中各成份配伍后发生了协同增效作用，值得临床推广应用。
在对以上治疗组患者进行随访时，其中有3例自述“使用本发明的气雾剂后，不但银屑病得到了有效治疗，而且急性期血栓性静脉炎症状也好了”。得到这一消息后，我们随即对30例患有不同程度急性期血栓性静脉炎患者，采用本发明气雾剂进行喷雾治疗。疗效标准：治愈指局部静脉索条肿物及疼痛消失，无任何自觉症状。有效指仍有条索状改变，局部、疼痛红肿减轻，硬结消失。无效指局部疼痛、红肿及索条状硬物无明显变化，硬结仍存在。治疗结果：30例患者中，痊愈18例(60％)，显效9例(30％)，无效3例(90％)，总有效率按痊愈和显效计，为90％。由此可知，服用本发明的气雾剂，不但治疗银屑病疗效显著，而且对急性期血栓性静脉炎具有很好的治疗效果，值得临床推广应用。
具体实施方式
该预防银屑病复发药剂包括组份A和组份B，所述组份A为吡硫翁锌气雾剂，所述组份B为生物提取物；所述生物提取物由血竭30g、皂荚80g、地肤子60g、土瓜狼毒65g、徐长卿45g、黄药子55g、花椒90g、白花蛇舌草90g、虎掌草77g、乳香44g、木鳖子54g、紫弹树160g、蝉蜕33g、菊花43g、白芥子120g粉碎混匀，加入10倍生物材料重量的蒸馏水浸泡40min后武火加热煮沸，沸腾后改用文火，保持微沸30min，搅拌，趁热过滤，再加适量蒸馏水同法煎煮20min滤过，合并滤液，水煎液经浓缩至400ml，加入95％乙醇，边加边搅拌，使杂质沉淀析出，放置24h滤过，滤液经水浴蒸发至无醇味，加蒸馏水定容至200ml，以60kPa，30min灭菌制成；使用时，将组份A与组份B按照重量比1∶2的比例充分混合即得本发明所述的预防银屑病复发的气雾剂。

Claims (3)

1.一种预防银屑病复发的药剂，其特征在于该药剂包括组份A和组份B，所述组份A为吡硫翁锌气雾剂，所述组份B为生物提取物。
2.根据权利要求1所述的一种预防银屑病复发的药剂，其特征在于生物提取物由血竭30g、皂荚80g、地肤子60g、土瓜狼毒65g、徐长卿45g、黄药子55g、花椒90g、白花蛇舌草90g、虎掌草77g、乳香44g、木鳖子54g、紫弹树160g、蝉蜕33g、菊花43g、白芥子120g粉碎混匀，加入10倍生物材料重量的蒸馏水浸泡40min后武火加热煮沸，沸腾后改用文火，保持微沸30min，搅拌，趁热过滤，再加适量蒸馏水同法煎煮20min滤过，合并滤液，水煎液经浓缩至400ml，加入95％乙醇，边加边搅拌，使杂质沉淀析出，放置24h滤过，滤液经水浴蒸发至无醇味，加蒸馏水定容至200ml制成，以60kPa，30min灭菌制成。
3.根据权利要求1所述的一种预防银屑病复发的药剂，其特征在于将组份A与组份B按照重量比1∶2的比例充分混合即得本发明所述的预防银屑病复发的药剂。
CN201710122305.3A 2017-02-20 2017-02-20 一种预防银屑病复发的药剂 Pending CN106728702A (zh)

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