CN106728587A - A kind of antalgic Chinese medicine composition - Google Patents

A kind of antalgic Chinese medicine composition Download PDF

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CN106728587A
CN106728587A CN201710076443.2A CN201710076443A CN106728587A CN 106728587 A CN106728587 A CN 106728587A CN 201710076443 A CN201710076443 A CN 201710076443A CN 106728587 A CN106728587 A CN 106728587A
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parts
chinese medicine
medicine composition
antalgic
radix aconiti
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CN106728587B (en
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赵玲
宋薇
曾慧妍
张锦明
温建炫
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Guangdong Hospital of Traditional Chinese Medicine
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884Arisaema, e.g. Jack in the pulpit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of antalgic Chinese medicine composition, the Chinese medicine composition is made up of frankincense, myrrh, cassia twig, cooked aconite, rhizoma arisaematis, Radix Aconiti and Radix Aconiti Kusnezoffii, antalgic Chinese medicine composition of the present invention is with temperature through supporing yang, dispelling wind and removing obstruction in the meridians analgesic is method, compatibility is exquisite, and external application direct transdermal absorption is in pain part, without decocting, compliance is good, is adapted to long-term use;Chinese medicine composition clinically effect is significant, and economical and practical, by the favorable comment of patient, using not finding any adverse reaction so far.Antalgic Chinese medicine group of the present invention is powder, and using packed form, the effect permeated using hot compress is spread on affected area, repeatedly used, and can also make remission and healing, and economy is saved.

Description

A kind of antalgic Chinese medicine composition
Technical field
The invention belongs to the field of Chinese medicines, it is related to a kind of antalgic Chinese medicine composition.
Background technology
Osteoarthritis (osteoarthritis, OA) is denatured with articular cartilage progressive, destroyed and lost, and joint is soft Bone and subchondral bone edge spur are formed and articular surface is hardened to basic pathological changes.And osteoporosis (Osteoporosis, OP it is) a kind of low with bone amount, bone micro-structure destruction, causes bone fragility to increase, the general osteopathy that fracture is characterized easily occurs (World Health Organization, WHO).The most significant symptom of above-mentioned two disease is pain, can also be received with powerless, limb activity Limit, have a strong impact on work and the life quality of patient.
Treatment of the doctor trained in Western medicine to OA and OP is main based on anti symptom treatment and operative treatment, but has long-term use adverse reaction Many weak points such as greatly, surgery cost is high, complication is more, patient suffering is big.Osteoarthritis and osteoporosis are showed There is endo-medicine to treat generally not notable to the therapeutic effect of focus, and medicine time is long, easily makees so that human body product is secondary, Bing Renyi Poor from property, medical expense is also higher.Traditional externally applied plaster is not obvious to the therapeutic effect of Osteoarthritis and osteoporosis Or it is unstable, and plaster outer plaster is usually present allergic, and just can not apply again after plaster is torn from skin, relatively wastes.
The content of the invention
In order to solve above-mentioned problem, specific a few herbs are ground into powder by the present invention by creative research Last shape, then it is well mixed by specific proportioning, using packed form, the effect permeated using hot compress is spread on affected area, reached Temperature makes remission and healing through supporing yang, dispelling wind and removing obstruction in the meridians analgesic.Antalgic Chinese traditional medicine composition of the present invention is to Osteoarthritis and bone The curative effect of matter osteoporosis is especially pronounced.
It is an object of the invention to provide a kind of antalgic Chinese medicine composition.
The technical solution used in the present invention is:
A kind of antalgic Chinese medicine composition, the Traditional Chinese medicine composition formula is:Frankincense 10-100 parts, myrrh 10-100 parts, cassia twig 10-100 parts, cooked aconite 10-100 parts, rhizoma arisaematis 10-100 parts, Radix Aconiti 10-100 parts, Radix Aconiti Kusnezoffii 10-100 parts, more than it is Mass parts.
A kind of antalgic Chinese medicine composition, the Traditional Chinese medicine composition formula is:45 ~ 55 parts of frankincense, 45 ~ 55 parts of myrrh, osmanthus 45 ~ 55 parts of branch, 45 ~ 55 parts of cooked aconite, 45 ~ 55 parts of rhizoma arisaematis, 45 ~ 55 parts of Radix Aconiti, 45 ~ 55 parts of Radix Aconiti Kusnezoffii is more than matter Amount part.
A kind of antalgic Chinese medicine composition, the Traditional Chinese medicine composition formula is:50 parts of frankincense, 50 parts of myrrh, 50 parts of cassia twig, 50 parts of cooked aconite, 50 parts of rhizoma arisaematis, 50 parts of Radix Aconiti, 50 parts of Radix Aconiti Kusnezoffii is more than mass parts.
Further, above-mentioned Chinese medicine composition is powder.
The preparation method of antalgic Chinese medicine composition described above, it is characterised in that crush each raw material Chinese medicine respectively It is well mixed by any of the above-described described proportioning to powder, you can.
The beneficial effects of the invention are as follows:
1)With temperature through supporing yang, dispelling wind and removing obstruction in the meridians analgesic is method to antalgic Chinese medicine composition of the present invention, and compatibility is exquisite, and external application is direct , in pain part, without decocting, compliance is good, is adapted to long-term use for percutaneous absorption;Chinese medicine composition clinically effect Significantly, it is and economical and practical, by the favorable comment of patient, using not finding any adverse reaction so far.
2)Antalgic Chinese traditional medicine composition of the present invention has synergy well, plays temperature through supporing yang, dispelling wind and removing obstruction in the meridians analgesic Effect, makes remission and healing, and the curative effect to Osteoarthritis and osteoporosis is especially pronounced.
3)Association well is served in clinical detection result explanation antalgic Chinese medicine composition of the present invention between each composition Same-action, generating temperature well, through supporing yang, dispelling wind and removing obstruction in the meridians analgesic effect, makes remission and healing, to Osteoarthritis and The curative effect of primary osteoporosis is especially pronounced, and up to more than 96%, determined curative effect safely, has no side effect effective percentage, patient Compliance is high, with actual clinical meaning.
4)Antalgic Chinese medicine group of the present invention is powder, and using packed form, the effect permeated using hot compress spreads on disease At stove, repeatedly use, can also make remission and healing, economy is saved.
Specific embodiment
With reference to specific embodiment, the present invention is further illustrated, but is not limited thereto.
The antalgic Chinese medicine composition of embodiment 1
Raw material:Frankincense(Frankincense, Olibanum), myrrh(Myrrh), cassia twig(Ramulus Cinnamomi), it is ripe Monkshood(Prepared Common Monkshood Daughter Root, Prepared daughter root of Common Monkshood), rhizoma arisaematis(Pedate PinalliaJackinthepulpit Rhizome, Jackinthepulpit Tuber), Radix Aconiti(Combined Spicebush Root, Root of Combined Spicebush), Radix Aconiti Kusnezoffii(Combined Spicebush Root, Root of Combined Spicebush).It is wherein newborn Fragrant is Yunnan product, and myrrh and cassia twig are that is produced from Guangdong, and cooked aconite, rhizoma arisaematis, Radix Aconiti and Radix Aconiti Kusnezoffii are Sichuan product.
Formula:50 parts of frankincense, 50 parts of myrrh, 50 parts of cassia twig, 50 parts of cooked aconite, 50 parts of rhizoma arisaematis, 50 parts of Radix Aconiti, sward 50 parts of crow, is more than mass parts.
Preparation method:Each raw material Chinese medicine is crushed to powder respectively, it is well mixed by formula described above, use sack bag It is good.
Usage:When using, external application affected part after the Chinese medicine composition heating that will be wrapped with sack, 2 times a day.
The antalgic Chinese medicine composition of embodiment 2
Formula:45 parts of frankincense, 45 parts of myrrh, 50 parts of cassia twig, 45 parts of cooked aconite, 50 parts of rhizoma arisaematis, 55 parts of Radix Aconiti, Radix Aconiti Kusnezoffii 55 Part, more than it is mass parts.
Preparation method:Each raw material Chinese medicine is crushed to powder respectively, it is well mixed by formula described above, use sack bag It is good.
Usage:When using, external application affected part after the Chinese medicine composition heating that will be wrapped with sack, 2 times a day.
The antalgic Chinese medicine composition of embodiment 3
Formula:55 parts of frankincense, 55 parts of myrrh, 45 parts of cassia twig, 55 parts of cooked aconite, 45 parts of rhizoma arisaematis, 55 parts of Radix Aconiti, Radix Aconiti Kusnezoffii 55 Part, more than it is mass parts.
Preparation method:Each raw material Chinese medicine is crushed to powder respectively, it is well mixed by formula described above, use sack bag It is good.
Usage:When using, external application affected part after the Chinese medicine composition heating that will be wrapped with sack, 2 times a day.
The antalgic Chinese medicine composition of embodiment 4
Formula:55 parts of frankincense, 55 parts of myrrh, 55 parts of cassia twig, 45 parts of cooked aconite, 55 parts of rhizoma arisaematis, 45 parts of Radix Aconiti, Radix Aconiti Kusnezoffii 45 Part, more than it is mass parts.
Preparation method:Each raw material Chinese medicine is crushed to powder respectively, it is well mixed by formula described above, use sack bag It is good.
Usage:When using, external application affected part after the Chinese medicine composition heating that will be wrapped with sack, 2 times a day.
Make further clinical efficacy detection to antalgic Chinese medicine composition of the present invention below.
First, the clinical efficacy to Osteoarthritis is detected
1. knee osteoarthritis patients data
142 patients of knee osteoarthritis patients, wherein male 45, women 97, the age are minimum 30 years old, and maximum 86 Year, average age 62.33 ± 13.27 years old;
2 diagnostic criteria
With reference to osteology branch of Chinese Medical Association《Bones and joints diagnosis and treatment guide》(Version in 2007).
1. having most of time in the preceding moon has goinyalgia.
2. X lines piece shows joint margins spur.
3. joint fluid inspection meets Osteoarthritis.
4. the age was more than 40 years old.
5. morning stiffness is less than 30 points.
6. there is bony crepitus during joint motion.
Meet 1.+2. bar, or 1.+3.+5.+6. bar, or 1.+4.+5.+6. diagnosable knee joint bone of bar person Property arthritis.
3 inclusive criterias
1. knee joint osseous arthritis diagnostic criteria person is met.
2. the age is at 25-90 Sui.
3. the course of disease is between -8 years 3 months.
4. can according to plan adhere to treatment, and coordinate this subject study person.
4 therapeutic schemes
The antalgic external application of Chinese medicine(External application affected part, daily 2 after being heated with the antalgic Chinese medicine composition of the preparation of embodiment 1 It is secondary), the symptomatic conditions such as statistics patient articular's pain are observed after 3 weeks.
5 criterions of therapeutical effect
Curative effect of disease standard:With reference to《New Chinese medicine treats the guideline of clinical investigations of Osteoarthritis》:
It is effective:The symptoms such as pain, swelling, somatic feature score reduce >=70%(Integration reduces prompting symptom, sign to be improved earlier above), close Section activity is unrestricted.
Effectively:The symptoms such as pain, swelling, somatic feature score reduce the joint motions of >=30%, < 70% to be improved.
It is invalid:The symptoms such as pain, swelling, somatic feature score are reduced less than 30%, and joint motion is unchanged.
6 treatment results
In 142, cure 61(42.96%), effective 77(54.23%), invalid 4(2.82%).
2nd, the clinical efficacy to primary osteoporosis is detected
1 patients with primary osteoporosis data
51 patients of patients with primary osteoporosis, wherein male 16, women 35, the age are minimum 40 years old, maximum 78 years old, put down Equal 58.6 ± 15.89 years old age.
2 diagnostic criteria
Reference《Research of osteoporotic diagnosis standards in China Consensus of experts》(2014 editions).
1. dual intensity X line absorptions method(DXA)Determine:SD category in T value >=-1.0 is normal;-2.5SD <T values< - 1.0 SD are that bone amount is low or bone amount is reduced;T value≤- 2.5 SD is osteoporosis;Reduction degree meets osteoporosis Disease diagnostic criteria, while with one or multiple fracture is serious osteoporosis.
2. secondary osteoporosis are excluded
3 inclusive criterias
1. primary osteoporosis diagnostic criteria person is met.
2. the age is at 40-80 Sui.
3. can according to plan adhere to treatment, and coordinate this subject study person.
4 therapeutic schemes
External application affected part after being heated with the antalgic Chinese medicine composition of the preparation of embodiment 1,2 times a day, and statistics patient is observed after 3 weeks The symptomatic conditions such as arthralgia.
5 efficacy assessment standards and result:
Cure:The symptoms such as whole body ostalgia, arthroncus, dysfunction are wholly absent, and joint motion is without sense of discomfort.
Effectively:The symptoms such as whole body ostalgia, arthroncus, dysfunction are wholly absent, and joint motion is slightly limited.
It is invalid:The symptoms such as whole body ostalgia, arthroncus, dysfunction are not improved.
6 treatment results
In 51, cure 19(37.25%), effective 29(56.86%), invalid 2(3.92%).
Served well between each composition in above-mentioned clinical detection result explanation antalgic Chinese medicine composition of the present invention Synergy, generating temperature well, through supporing yang, dispelling wind and removing obstruction in the meridians analgesic effect, makes remission and healing, to Osteoarthritis Curative effect with primary osteoporosis is especially pronounced, and up to more than 96%, determined curative effect safely, has no side effect effective percentage, disease People's compliance is high, with actual clinical meaning.
Above-described embodiment is the present invention preferably implementation method, but embodiments of the present invention are not by above-described embodiment Limitation, it is other it is any without departing from Spirit Essence of the invention and the change, modification, replacement made under principle, combine, simplification, Equivalent substitute mode is should be, is included within protection scope of the present invention.

Claims (5)

1. a kind of antalgic Chinese medicine composition, it is characterised in that the Traditional Chinese medicine composition formula is:Frankincense 10-100 parts, myrrh 10-100 parts, cassia twig 10-100 parts, cooked aconite 10-100 parts, rhizoma arisaematis 10-100 parts, Radix Aconiti 10-100 parts, Radix Aconiti Kusnezoffii 10- 100 parts, more than it is mass parts.
2. a kind of antalgic Chinese medicine composition according to claim 1, it is characterised in that the Traditional Chinese medicine composition formula For:45 ~ 55 parts of frankincense, 45 ~ 55 parts of myrrh, 45 ~ 55 parts of cassia twig, 45 ~ 55 parts of cooked aconite, 45 ~ 55 parts of rhizoma arisaematis, Radix Aconiti 45 ~ 55 parts, 45 ~ 55 parts of Radix Aconiti Kusnezoffii is more than mass parts.
3. a kind of antalgic Chinese medicine composition according to claim 1, it is characterised in that the Traditional Chinese medicine composition formula For:50 parts of frankincense, 50 parts of myrrh, 50 parts of cassia twig, 50 parts of cooked aconite, 50 parts of rhizoma arisaematis, 50 parts of Radix Aconiti, 50 parts of Radix Aconiti Kusnezoffii, with On be mass parts.
4. according to a kind of any described antalgic Chinese medicine composition of claim 1 ~ 3, it is characterised in that the Chinese medicine composition It is powder.
5. the preparation method of any antalgic Chinese medicine composition of claim 1 ~ 4, it is characterised in that by each raw material Chinese medicine Powder is crushed to respectively, is well mixed by any described proportioning of claim 1 ~ 3, you can.
CN201710076443.2A 2017-02-13 2017-02-13 Traditional Chinese medicine composition for warming channels and relieving pain Active CN106728587B (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103393840A (en) * 2013-07-24 2013-11-20 赵世明 Traditional Chinese medicine composition for treating osteoarthritis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103393840A (en) * 2013-07-24 2013-11-20 赵世明 Traditional Chinese medicine composition for treating osteoarthritis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
周英妮等: "自制温经散寒中药盐包烫熨治疗膝关节骨性关节炎72例", 《广西中医药》 *

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