CN106728538A

CN106728538A - It is a kind of to treat external used medicine of tympanitis and preparation method thereof

Info

Publication number: CN106728538A
Application number: CN201611075891.2A
Authority: CN
Inventors: 黄荣; 黄宣霖
Original assignee: Lucky Bio Tech Ltd Of Liuzhou Grass Seed
Current assignee: Lucky Bio Tech Ltd Of Liuzhou Grass Seed
Priority date: 2016-11-30
Filing date: 2016-11-30
Publication date: 2017-05-31

Abstract

The present invention discloses a kind of external used medicine for treating tympanitis, is made up of raw materials such as the achene of Siberian cocklebur, garden burnet, meadowrueleaf corydalis root, snake slough, kiss-me, Gaultheria, hypericum japonicum, Verbena officinalis, giant knotweed, tassel flower, Herba Andrographitis, water wax gourd, longleaf arrowhead herb, sargentodoxa cuneata, caulis trachelospermi, Japanses beauty-berry, hedgehog skins.The external used medicine for the treatment of tympanitis of the invention is prepared from by several kinds of Chinese medicinal materials, each medicinal material property of medicine complements each other, and safety is gentle, to human body Small side effects, with the effect such as anti-inflammatory analgesic, promoting blood circulation to remove blood stasis, astringing to arrest bleeding, sensible, removing toxic substances, the tympanitis that a variety of causes causes can effectively be treated, significantly improve duct suppurate, itch, pain, fester increases, fester has stink, the illness such as the symptoms such as Hearing, tinnitus and tympanic membrane perforation complication, from basic treatment, is difficult recurrence；And application method is convenient, short treating period, instant effect safely and effectively, is applicable crowd extensively, has broad application prospects.

Description

It is a kind of to treat external used medicine of tympanitis and preparation method thereof

Technical field

The present invention relates to field of medicaments, and in particular to a kind of to treat external used medicine of tympanitis and preparation method thereof.

Background technology

Tympanitis is common clinical, is the infectivity or inflammatory disease of middle ear institutional framework.This inflammation is typically source In pharyngeal infection, catch a cold or other breathing problems.Clinical each age level has morbidity, is that children seek medical advice most common original Therefore one.Clinical symptoms are mainly shown as：Duct suppurates, itches, pain, intermittent or continuation, suppurated during acute infection breaking-out or Fester increases, and fester property is mucus or viscous purulence, and not clearing up can have stink for a long time.More can there are not Hearing, ear for a long time Symptom and the tympanic membrane perforation complication such as ring.

The traditional Chinese medical science thinks that ear disease is, because evil poison of causing a disease is invaded, body normal physiological function is lacked of proper care, so as to disease occur Reason change, specific to tympanitis, as liver and gallbladder damp-heat, perverse trend is prevailing caused.When body healthy tendency is vigorous, perverse trend be just difficult invade and Generation disease, therefore《Plain Questions writings left behind by the deceased acupuncture manipulation is discussed》Say：" healthy tendency deposits interior, and heresy can not be done.If " the positive deficiency of vital energy, perverse trend takes advantage of a weak point, Disease can occur, therefore《Plain Questions comments pyretography》Say：" heresy is gathered, and its gas must be empty." therefore, otitis media diseases are The reflection of good and evil struggle, is the result of vital organs of the human body functional disturbance.In otopathy, pathogenic exopathogen is more common in wind, heat, damp evil.

Current western medical treatment tympanitis is more based on simple form local application, is consolidated with class with aqueous topical antibiotics or antibiotic Alcohol hormone medicine mixed liquor, such as 0.25% chloromycetin solution, chloramphenicol cortisone liquid, ofloxacin ear drops, treat middle ear Scorching and otitis externa etc..Markedly fast, but cure the symptoms, not the disease, and illness is easily repeatedly.In addition, in also having many treatment tympanitis Medicine, but most of have the shortcomings that therapeutic effect is poor, cure rate is low and treatment cycle is long.Accordingly, it would be desirable to invent a kind of side effect Small, good effect, treatment cycle is short, is difficult the medicine of the treatment tympanitis of recurrence.

The content of the invention

It is contemplated that inventing a kind of external used medicine for treating tympanitis, the medicine has anti-inflammatory analgesic, promoting blood circulation to remove blood stasis, receipts The effect such as hemostasis, sensible, removing toxic substances is held back, for treating tympanitis effect is significant.

For achieving the above object, technical scheme is as follows：

The external used medicine for the treatment of tympanitis of the invention, it is prepared from by the raw material including following weight portion：

Achene of Siberian cocklebur 20-50 parts, garden burnet 20-50 parts, meadowrueleaf corydalis root 20-50 parts, snake slough 20-50 parts, kiss-me 10-25 parts, Gaultheria 10-25 parts, hypericum japonicum 5-15 parts, Verbena officinalis 5-15 parts, giant knotweed 8-25 parts, tassel flower 8-25 parts, Herba Andrographitis 5-15 parts, water wax gourd 10-25 parts, longleaf arrowhead herb 5-15 parts, sargentodoxa cuneata 5-15 parts, caulis trachelospermi 5-15 parts, Japanses beauty-berry 8-20 parts, hedgehog skin 10-20 parts.

Preferably, it is to be prepared from by the raw material of following weight portion：

Achene of Siberian cocklebur 30-40 parts, garden burnet 30-40 parts, meadowrueleaf corydalis root 30-40 parts, snake slough 30-40 parts, kiss-me 15-20 parts, Gaultheria 15-20 parts, hypericum japonicum 8-12 parts, Verbena officinalis 8-12 parts, giant knotweed 15-20 parts, tassel flower 15-20 parts, Herba Andrographitis 8-12 parts, water winter Melon 15-20 parts, longleaf arrowhead herb 8-12 parts, sargentodoxa cuneata 7-12 parts, caulis trachelospermi 7-12 parts, Japanses beauty-berry 12-16 parts, hedgehog skin 12-16 parts.

The source of the medicinal material used the following is the external used medicine of present invention treatment tympanitis and effect：

The achene of Siberian cocklebur, alias Siberian cocklebur, stout pale are sub, grey sub-, Xi ear, Fructus Xanthii etc., are feverfew Siberian cocklebur Xanthium Fruit of the drying and ripening of sibiricum Patr. with involucre.Pungent, hardship, temperature；It is poisonous.Wind dehumidifying, clearing the nasal passage can be dissipated.For wind Cold headache, nasosinusitis runny nose, rubella itch, arthritis with fixed pain caused by dampness contraction.

Garden burnet, alias garden burnet, beautiful letter, mountain jujube etc., are rosaceous plant garden burnet Sanguisorba officinalis Or the garden burnet Sanguisorba off icinalis L.var.longifolia that come into leaves L.（Bert.）The drying of Yu et Li Root.It is bitter, sour, puckery, it is slightly cold.Can cooling blood and hemostasis, removing toxic substances sore.For having blood in stool, hemorrhoid blood, bloody flux, uterine bleeding, scald, carbuncle swells sore Poison.

Meadowrueleaf corydalis root, alias rock recklessly, the root of bloodroot meadowrueleaf corydalis root.Hardship, it is cool.Can be clearing heat and detoxicating, dampness removing, analgesic hemostatic.

Snake slough, alias snakeskin, snake move back, snake skin, imperial clothing, snake shell, are Colubridae animal elaphe taeniurus Cope Elaphe Taeniura Cope, rat snake Elaphe carinata（Guenther）Or zaocys dhumnade Zaocys dhumnades （Cantor）Epidermis film is dried etc. under sloughing off.It is salty, sweet, put down.Can wind-dispelling, arresting convulsion, removing toxic substances, move back screen.For child convulsion, tic convulsion Contraction, ocular, larynx numbness, malignant boil swells, pruitus.

Kiss-me, alias stone lotus, lion ear, deaf grass, spun gold lotus leaf, spun gold hang lotus etc., are saxifragaceae plant The herb of kiss-me Saxifraga stolonifera Meerb. [S. sarmentosa L. f.].Bitter, acrid, cold.Have small Poison.Can be clearing heat and detoxicating.For fever in children, cough and asthma；Tympanitis is controlled in external application, and auricle festers, furunculosis, furuncle, eczema.

Gaultheria, alias Caulis et folium gaultheriae yunnanensis tree, small lopseed, deep perfume, ZUANGUFENG, live charcoal, lopseed [Yunnan, Guizhou], Spice all over the mountain, fragrant, bathing leaf, teaberry etc., are Ericaceae Gaultheria plant Caulis et folium gaultheriae yunnanensis Gaultheria yunnanensis （Franch.）Rehd., it is used as medicine with complete stool.It is pungent, temperature.Dispelling wind and eliminating dampness, stimulates the circulation of the blood and cause the muscles and joints to relax, promoting blood circulation and stopping pain.For wind Wet arthritis, traumatic injury, stomach cold pain.Anemofrigid cold.

Hypericum japonicum, alias hypericum japonicum, field base king, small hypericum japonicum, sweet vernal grass, slimyhair sida leaf or root, hancock swallowwort herb, seven cun of gold, spires are yellow Deng being Hypericaceae hypericum hypericum japonicum Hypericum japonicum Thunb. with all herbal medicine.Sweet, slight bitter, It is cool.Can clearing heat and promoting diuresis, removing toxicity for detumescence, blood stasis removing analgesic.For hepatitis, early-phase hepatocirrhosis, appendicitis, eye conjunctivitis, tonsillitis； Sore furuncle poison, herpes zoster, venomous snake bite, traumatic injury are controlled in external application.

Verbena officinalis, is the dry aerial parts of Verbenaceae Verbena officinalis Verbena officinalis L..Hardship, It is cool.Can promoting blood circulation to remove blood stasis, preventing malaria, removing toxic substances, inducing diuresis for removing edema.For a lump in the abdomen causing distension and pain, closed dysmenorrhea, malaria, larynx numbness, carbuncle swells, oedema, heat Drench.

Giant knotweed, alias vacation river seven, native river seven, Rhizoma Polygoni suffulti, pseudo-ginseng or Japanese knotweed, are polygonaceae plant giant knotweed Polygonum Cuspidatum Sieb. et Zucc., dry rhizome and root.Slight bitter, is slightly cold.Return liver, courage, lung channel.It is clearing heat and detoxicating, cholagogic Removing jaundice, expelling wind and removing dampness, scattered stasis pain is relieving cough and reducing sputum.For joint pain, jaundice with damp-heat pathogen, Amenorrhea , wei lumps in the abdomen, coughing with a lot of sputum, extreme misery Scald, injury from falling down, carbuncle sore tumefacting virus.

Tassel flower, alias redback chrismashush root and leaf, leaf lower red, sowthistle tasselflower herb etc., are composite family tassel flower platymiscium tassel flower Emilia sonchifolia （L.）DC., with all herbal medicine.Hardship, it is cool.Can be clearing heat and detoxicating, eliminating stasis to subdue swelling.The infection of the upper respiratory tract, throat swells Bitterly, canker sore, pneumonia, chordapsus, bacillary dysentery, urinary system infection contamination, orchitis, mastitis, furuncle sore, skin Eczema, bruises and sprains.

Herba Andrographitis, alias Euphorbia, Banlangen, cuts tongue sword, eel grass, andrographis paniculata, longleaf rabdosia stem etc., is acanthaceous plant punching Lotus（Circular cone must medicinal herbs）Andrographis paniculata （Burm. f. ）The dry aerial parts of Nees.Hardship, trembles with fear. Can be clearing heat and detoxicating, cool blood, detumescence.For cold, fever, abscess of throat, aphthae, pertussis labor is coughed, and dysentery, heat gonorrhea is puckery Bitterly, carbuncle swells sore, venomous snake bite.

Water wax gourd, latin name Adina racemosa (Sieb. Et Zucc.) Miq. alias toad wood, pears are young, are madder The complete stool of the young wood of section plant chicken.Hardship, it is cool.Can be clearing heat and detoxicating, promoting blood circulation to remove blood stasis.For cold, fever, cough with lung heat, gastroenteritis, dysentery Disease, acute toothache, swollen ulcer drug, eczema, traumatic injury, traumatism and bleeding.

Longleaf arrowhead herb, latin name Sagittaria trifolia L. Var. Angusti-folia (Sieb.) Kitag., alias scissors grass, arrowhead seedling, Herba Passiflorae Cupiformis etc., are that Notes On Alism At Aceae comes into leaves the herb of rhizoma alismatis.It is pungent, it is cool, it is nontoxic.Can disappear Swollen analgesic, removing toxic substances, for sore swells, erysipelas dislikes sore.

Sargentodoxa cuneata, is plants of Lardizabalaceae sargentodoxa cuneata Sargentodoxa cuneata (Oliv.) Rehd.et Wils. Stem.Hardship, puts down.Can be clearing heat and detoxicating, promoting blood circulation, wind-dispelling.For abdominalgia with intestinal abscess, closed dysmenorrhea, arthralgia pain due to rheumatism, tumbling and swelling.

Caulis trachelospermi, is apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides（Lindl.）Lem. Dry zone leaf rattan.Hardship, is slightly cold.Can dispelling wind and removing obstruction in the meridians, cool blood detumescence.For beriberoid pyretic arthralgia, muscle arteries and veins contraction, soreness of waist and knee joint, larynx numbness, Carbuncle swells, injury from falling down.

Japanses beauty-berry, alias Japanses beauty-berry grass, Folium Callicarpae Formosanae are Verenaceae Japanses beauty-berry platymiscium callicarpa pedunculata Callicarpa Pedunculata R. Brown and Callicarpa dichotoma C. dichotoma（Lour.）K. Koch., is used as medicine with stem, leaf and root. It is bitter, puckery, put down.Can stop blooding, dissipate the stasis of blood, anti-inflammatory.For bleeding from five sense organs or subcutaneous tissue, spitting of blood, gastrointestinal bleeding, uterine hemorrhage, the infection of the upper respiratory tract, tonsillotome Inflammation, pneumonia, bronchitis；Traumatism and bleeding is controlled in external application, burn.

Hedgehog skin, alias hedgehog skin, agouti skin, the sub- skin of acanthosphere etc., are Erinaceidae animal hedgehog Erinaceus europaeus Or short hedgehog Hemichianus dauricus Sundevall dry crust L..Bitter, sweet, flat.Feasible stasis of blood analgesic, hemostasis, Controlling nocturnal emission with astringent drugs.For gastral cavity pain, uterine hemorrhage is had blood in stool, hemorrhoid, seminal emission, the enuresis.

Toddalia, alias spinyleaf pricklyash root, rescue greatly, asiatic toddalia root-bark, tiger of going down the hill, le hook, Huang great Jin roots etc., be Rutaceae flying dragon Palm blood platymiscium toddalia Toddalia asiatica（L.）Lam. [T. aculeata Pers.], is used as medicine with root or leaf. Pungent, slight bitter, temperature.Dissipate stasis of blood hemostasis, dispelling wind and eliminating dampness, subdhing swelling and detoxicating.Root skin：Traumatic injury, rheumatic arthritis, intercostal neuralgia, Stomachache, irregular menstruation, dysmenorrhoea, amenorrhoea；Fracture, traumatism and bleeding are controlled in external application.Leaf：Carbuncle furuncle poison, venomous snake bite are controlled in external application.

It is a further object of the present invention to provide the preparation method of the active component of external used medicine of the present invention, the method is to use The ethanol of water extraction or 40-70% concentration expressed in percentage by volumes is extracted and is prepared from.Specific preparation method is as follows：

Scheme one：Whole raw material are taken, extracting in water 2-3 times after mixing, 6- of each amount of water equivalent to raw material gross weight 12 times, each extraction time is 1-3 hours, merges extract solution, is filtered, and relative density is when filtrate is concentrated into 70-80 DEG C The clear cream of 1.15-1.20, obtains final product active component.

Scheme two：Whole raw material are taken, is extracted 2-3 times with 40-70% alcohol refluxs after mixing, each ethanol consumption is medicine 4-10 times of material total amount, extraction time is 1-4 hours, merges extract solution, is filtered, and filtrate is concentrated into relatively close at 70-80 DEG C The clear cream for 1.15-1.20 is spent, active component is obtained final product.

Scheme three：Whole raw material are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight 6-12 times, each extraction time is 1-3 hours, merges extract solution, is filtered, and relative density is when filtrate is concentrated into 70-80 DEG C The clear cream of 1.15-1.20, adds ethanol, makes alcohol content for 40-60%, stands 12-24 hours, and filtration, filtrate is concentrated into 70- Relative density is the medicinal extract of 1.10-1.25 at 80 DEG C, obtains final product active component.

The external used medicine for the treatment of tympanitis of the present invention, is prepared by the following method and forms：Take scheme one to One of gained active component of scheme three, adds hydrogen peroxide and peppermint oil, and 20- is homogenized with ultrasonic wave at 0-15 DEG C after mixing 40min, obtains final product；The consumption of the hydrogen peroxide is 40-80 times of active component weight；The consumption of the peppermint oil is active component The 10-50% of weight.

When using, above-mentioned external used medicine is taken, ear bath is used.

The external used medicine for the treatment of tympanitis of the present invention, is prepared by the following method and forms：Claim by weight Whole medicinal materials are taken, is respectively put into ceramic pan, fired with timber after adding a cover and burnt to full charing, be well mixed after crushing, sterilizing, i.e., .

When using, first cleaned in ear with hydrogen peroxide, above-mentioned external used medicine taken with small suction pipe after drying ear, be blown into ear, .

The applicant combines Traditional Chinese Medicine Coryza Treated by Syndrome Differentiation and modern pharmacological research achievement, by development test for many years, compares Multiple formulations, the external application Chinese medicine formula of illness such as draw the tympanitis effectively treated all kinds of reasons and cause, ear flowing water, suppurate. On the one hand the external used medicine that the present invention is provided selects the achene of Siberian cocklebur, kiss-me, garden burnet, meadowrueleaf corydalis root, snake slough etc. drug matching, to reach To eliminating inflammation and expelling toxin, effect of healing up sore and subduing swelling；On the one hand, the Chinese medicine such as selection Bai Shuzhu, hypericum japonicum, Verbena officinalis, performance promoting blood circulation and stopping pain, The effect of scattered stasis detumescence；Longleaf arrowhead herb, Herba Andrographitis can swelling and pain relieving, removing toxic substances；Secondly, the formula of the external used medicine that the present invention is provided, Add has the conventional seedling medicine of remarkable result, such as giant knotweed, sargentodoxa cuneata, caulis trachelospermi, Japanses beauty-berry, toddalia to treating all kinds of tympanitis Deng they are mutually coordinated with plurality of Chinese compatibility, have both played itself drug effect, and the toxic and side effect of medicinal material can be mitigated again；Above each side Face is combined, not only the duct that tympanitis causes is suppurated using the external used medicine of the treatment tympanitis of present invention offer, is itched, Bitterly, fester increases, and fester has the symptoms and tympanic membrane perforation complication etc. such as stink, Hearing, tinnitus to have obvious anti-inflammatory town Pain effect, at the same can promoting blood circulation to remove blood stasis, astringing to arrest bleeding, it is sensible, removing toxic substances, reach treat both principal and secondary aspect of disease, be difficult recurrence effect

Beneficial effects of the present invention are：

（1）The external used medicine for the treatment of tympanitis of the invention is prepared from by several kinds of Chinese medicinal materials, and each medicinal material property of medicine complements each other, peace It is complete gentle, to human body Small side effects, with the effect such as anti-inflammatory analgesic, promoting blood circulation to remove blood stasis, astringing to arrest bleeding, sensible, removing toxic substances, can effectively control Treat the tympanitis that causes of a variety of causes, significantly improve duct suppurate, itch, pain, fester increases, and fester has stink, Hearing, ear The illnesss such as symptom and tympanic membrane perforation complication such as ring, from basic treatment, are difficult recurrence；

（2）It is of the invention treatment tympanitis external used medicine clinical tests prove that, treatment because tympanitis trigger duct suppurate, Itch, pain, fester increases, and fester has the illness such as symptom and tympanic membrane perforation complication such as stink, Hearing, tinnitus, it is total effectively Rate is 99.01%, illustrating the external used medicine of the treatment tympanitis of present invention offer has significant therapeutic effect；

（3）The topical formulations for the treatment of tympanitis of the invention are scientific and reasonable, and application method is convenient, short treating period, instant effect, peace It is complete effective, it is applicable crowd wide；And preparation method is simple, property of medicine stabilization has broad application prospects.

Specific embodiment

The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustrating The present invention is rather than limitation of the present invention.Essence of the invention belongs to the present invention to the simple modifications that the present invention is carried out Claimed scope.

Embodiment 1

Weigh achene of Siberian cocklebur 20g, garden burnet 20g, meadowrueleaf corydalis root 20g, snake slough 20g, kiss-me 10g, Gaultheria 10g, hypericum japonicum 5g, horsewhip Careless 5g, giant knotweed 8g, tassel flower 8g, Herba Andrographitis 5g, water wax gourd 10g, longleaf arrowhead herb 5g, sargentodoxa cuneata 5g, caulis trachelospermi 5g, Japanses beauty-berry 8g, thorn Hedgehog skin 10g.

Extracting in water 3 times after above material is mixed, each amount of water be respectively 10 times of medicinal material gross weight, 8 times, 6 Times, each extraction time is respectively 3 hours, 2 hours, 1 hour, merges extract solution, filters, and filtrate is concentrated into relative at 80 DEG C Density is 1.20 clear cream, adds ethanol, makes alcohol content be 60%, stands 24 hours, filtering, and filtrate is concentrated into relative at 80 DEG C Density is 1.25 medicinal extract, and the hydrogen peroxide of 40 times of medicinal extract weight and the peppermint oil of medicinal extract weight 10%, mixing are added in medicinal extract 20min is homogenized with ultrasonic wave at 0 DEG C afterwards, is obtained final product.

Embodiment 2

Weigh achene of Siberian cocklebur 22g, garden burnet 22g, meadowrueleaf corydalis root 23g, snake slough 22g, kiss-me 12g, Gaultheria 11g, hypericum japonicum 6g, horsewhip Careless 6g, giant knotweed 9g, tassel flower 10g, Herba Andrographitis 6g, water wax gourd 11g, longleaf arrowhead herb 6g, sargentodoxa cuneata 5g, caulis trachelospermi 6g, Japanses beauty-berry 10g, Hedgehog skin 10g.

Extracted 3 times with alcohol reflux after above material is mixed, each concentration of alcohol is respectively 70%, 60%, 45%, every time Ethanol consumption is respectively 8 times of medicinal material total amount, 5 times, 4 times, and extraction time is respectively 4 hours, 3 times, 2 hours, merges extract solution, Filtering, relative density is 1.20 medicinal extract when filtrate is concentrated into 80 DEG C, added in medicinal extract 45 times of medicinal extract weight hydrogen peroxide and The peppermint oil of medicinal extract weight 15%, 24min is homogenized after mixing at 2 DEG C with ultrasonic wave, is obtained final product.

Embodiment 3

Weigh achene of Siberian cocklebur 24g, garden burnet 23g, meadowrueleaf corydalis root 25g, snake slough 24g, kiss-me 12g, Gaultheria 12g, hypericum japonicum 7g, horsewhip Careless 7g, giant knotweed 11g, tassel flower 12g, Herba Andrographitis 7g, water wax gourd 12g, longleaf arrowhead herb 6g, sargentodoxa cuneata 6g, caulis trachelospermi 7g, Japanses beauty-berry 11g, Hedgehog skin 10g.

Extracting in water 3 times after above material is mixed, each amount of water be respectively 10 times of medicinal material gross weight, 8 times, 6 Times, each extraction time is respectively 3 hours, 2 hours, 1 hour, merges extract solution, filters, and filtrate is concentrated into relatively close at 80 DEG C Spend the clear cream for 1.20, the hydrogen peroxide of 50 times of clear cream weight and the peppermint oil of clear cream weight 20% added in clear cream, after mixing 27min is homogenized with ultrasonic wave at 5 DEG C, is obtained final product.

Embodiment 4

Weigh achene of Siberian cocklebur 28g, garden burnet 26g, meadowrueleaf corydalis root 27g, snake slough 28g, kiss-me 14g, Gaultheria 14g, hypericum japonicum 7g, horsewhip Careless 8g, giant knotweed 13g, tassel flower 14g, Herba Andrographitis 7g, water wax gourd 14g, longleaf arrowhead herb 7g, sargentodoxa cuneata 7g, caulis trachelospermi 8g, Japanses beauty-berry 12g, Hedgehog skin 11g.

Extracting in water 2 times after above material is mixed, each amount of water is respectively 12 times of medicinal material gross weight, 8 times, often Secondary extraction time is respectively 2 hours, 1 hour, merges extract solution, filters, and relative density is 1.16 when filtrate is concentrated into 75 DEG C Clear cream, adds ethanol, makes alcohol content be 50%, stands 18 hours, and filtration, concentration filtrate ad pond om is the 3 of medicinal material gross weight Times, concentrate filtrate in add concentration 55 times of filtrate weight hydrogen peroxide and concentration filtrate weight 25% peppermint oil, after mixing 30min is homogenized with ultrasonic wave at 7 DEG C, is obtained final product.

Embodiment 5

Weigh achene of Siberian cocklebur 30g, garden burnet 30g, meadowrueleaf corydalis root 30g, snake slough 30g, kiss-me 15g, Gaultheria 15g, hypericum japonicum 8g, horsewhip Careless 8g, giant knotweed 15g, tassel flower 15g, Herba Andrographitis 8g, water wax gourd 15g, longleaf arrowhead herb 8g, sargentodoxa cuneata 7g, caulis trachelospermi 8g, Japanses beauty-berry 12g, Hedgehog skin 12g.

Extracted 3 times with alcohol reflux after above material is mixed, each concentration of alcohol is respectively 60%, 50%, 40%, every time Ethanol consumption is respectively 8 times of medicinal material total amount, 6 times, 4 times, and extraction time is respectively 4 hours, 2 hours, 1 hour, merges and extracts Liquid, filtering, relative density is 1.18 medicinal extract when filtrate is concentrated into 78 DEG C, and the hydrogen peroxide of 60 times of medicinal extract weight is added in medicinal extract With the peppermint oil of medicinal extract weight 30%, 32min is homogenized with ultrasonic wave at 8 DEG C after mixing, obtained final product.

Embodiment 6

Weigh achene of Siberian cocklebur 35g, garden burnet 34g, meadowrueleaf corydalis root 35g, snake slough 34g, kiss-me 18g, Gaultheria 17g, hypericum japonicum 10g, horse Whip grass 10g, giant knotweed 17g, tassel flower 18g, Herba Andrographitis 10g, water wax gourd 17g, longleaf arrowhead herb 10g, sargentodoxa cuneata 9g, caulis trachelospermi 10g, purple Pearl 14g, hedgehog skin 14g.

Extracting in water 3 times after above material is mixed, each amount of water be respectively 10 times of medicinal material gross weight, 8 times, 6 Times, each extraction time is respectively 3 hours, 2 hours, 1 hour, merges extract solution, filters, and filtrate is concentrated into relatively close at 74 DEG C Spend the clear cream for 1.18, the hydrogen peroxide of 65 times of clear cream weight and the peppermint oil of clear cream weight 35% added in clear cream, after mixing 35min is homogenized with ultrasonic wave at 10 DEG C, is obtained final product.

Embodiment 7

Weigh achene of Siberian cocklebur 40g, garden burnet 40g, meadowrueleaf corydalis root 40g, snake slough 40g, kiss-me 20g, Gaultheria 20g, hypericum japonicum 12g, horse Whip grass 12g, giant knotweed 20g, tassel flower 20g, Herba Andrographitis 12g, water wax gourd 20g, longleaf arrowhead herb 12g, sargentodoxa cuneata 12g, caulis trachelospermi 12g, Japanses beauty-berry 16g, hedgehog skin 16g.

Extracting in water 2 times after above material is mixed, each amount of water is respectively equivalent to 10 times of medicinal material gross weight, 6 times, Each extraction time is distinguished 3 hours, 2 hours, merges extract solution, filters, and relative density is 1.15 when filtrate is concentrated into 70 DEG C Clear cream, add ethanol, make alcohol content for 40%, stand 12 hours, filtration, filtrate be concentrated into filtrate be concentrated into it is relative at 70 DEG C Density is 1.10 medicinal extract, and the hydrogen peroxide of 70 times of medicinal extract weight and the peppermint oil of medicinal extract weight 40%, mixing are added in medicinal extract 37min is homogenized with ultrasonic wave at 12 DEG C afterwards, is obtained final product.

Embodiment 8

Weigh achene of Siberian cocklebur 45g, garden burnet 46g, meadowrueleaf corydalis root 46g, snake slough 45g, kiss-me 23g, Gaultheria 22g, hypericum japonicum 14g, horse Whip grass 14g, giant knotweed 23g, tassel flower 22g, Herba Andrographitis 14g, water wax gourd 22g, longleaf arrowhead herb 14g, sargentodoxa cuneata 14g, caulis trachelospermi 14g, Japanses beauty-berry 18g, hedgehog skin 18g.

Extracted 2 times with alcohol reflux after above material is mixed, each concentration of alcohol is respectively 70%, 50%, each ethanol Consumption is respectively 10 times of medicinal material total amount, 8 times, and extraction time is respectively 4 hours, 2 hours, merges extract solution, and filtering, filtrate is dense Relative density is 1.15 medicinal extract when being reduced to 70 DEG C, and the hydrogen peroxide and medicinal extract weight 45% of 75 times of medicinal extract weight are added in medicinal extract Peppermint oil, homogenize 40min with ultrasonic wave at 14 DEG C after mixing, obtain final product.

Embodiment 9

Weigh achene of Siberian cocklebur 50g, garden burnet 50g, meadowrueleaf corydalis root 50g, snake slough 50g, kiss-me 25g, Gaultheria 25g, hypericum japonicum 15g, horse Whip grass 15g, giant knotweed 25g, tassel flower 25g, Herba Andrographitis 15g, water wax gourd 25g, longleaf arrowhead herb 15g, sargentodoxa cuneata 15g, caulis trachelospermi 15g, Japanses beauty-berry 20g, hedgehog skin 20g.

Will above material mix after mix after extracting in water 2 times, each amount of water be respectively 12 times of medicinal material gross weight, 10 times, each extraction time is respectively 3 hours, 2 hours, merges extract solution, filters, and relative density is when filtrate is concentrated into 70 DEG C 1.15 clear cream, adds the hydrogen peroxide of 80 times of clear cream weight and the peppermint oil of clear cream weight 50%, 15 after mixing in clear cream 40min is homogenized with ultrasonic wave at DEG C, is obtained final product.

Embodiment 10

Weigh achene of Siberian cocklebur 34g, garden burnet 32g, meadowrueleaf corydalis root 31g, snake slough 36g, kiss-me 15g, Gaultheria 16g, hypericum japonicum 9g, horsewhip Careless 11g, giant knotweed 15g, tassel flower 19g, Herba Andrographitis 12g, water wax gourd 14g, longleaf arrowhead herb 11g, sargentodoxa cuneata 8g, caulis trachelospermi 10g, Japanses beauty-berry 15g, hedgehog skin 12g.Medicinal material is respectively put into ceramic pan, is fired with timber after adding a cover and burnt to full charing, mixed after crushing equal Even, sterilizing is obtained final product.

Embodiment 11

Weigh achene of Siberian cocklebur 38g, garden burnet 40g, meadowrueleaf corydalis root 39g, snake slough 41g, kiss-me 19g, Gaultheria 17g, hypericum japonicum 12g, horse Whip grass 10g, giant knotweed 19g, tassel flower 18g, Herba Andrographitis 11g, water wax gourd 18g, longleaf arrowhead herb 9g, sargentodoxa cuneata 12g, caulis trachelospermi 10g, purple Pearl 15g, hedgehog skin 14g.Medicinal material is respectively put into ceramic pan, is fired with timber after adding a cover and burnt to full charing, mixed after crushing Uniformly, sterilize, obtain final product.

Embodiment 12

Weigh achene of Siberian cocklebur 48g, garden burnet 47g, meadowrueleaf corydalis root 46g, snake slough 50g, kiss-me 24g, Gaultheria 23g, hypericum japonicum 14g, horse Whip grass 10g, giant knotweed 21g, tassel flower 23g, Herba Andrographitis 15g, water wax gourd 20g, longleaf arrowhead herb 12g, sargentodoxa cuneata 14g, caulis trachelospermi 12g, Japanses beauty-berry 17g, hedgehog skin 18g.Medicinal material is respectively put into ceramic pan, is fired with timber after adding a cover and burnt to full charing, mixed after crushing Close uniform, sterilizing is obtained final product.

Clinical test is summarized

1 basic document

1.1 selection tympanitis disease patients 303, man 169, female 134, age 12-62 Sui, the course of disease is most long 18 months, most It is short 2 months.Exclude gestation and women breast-feeding their children, those who are allergic to this drug, adverse cardiac, liver diseases, hypertension, stomach patient.

2 treatment methods

Using the external used medicine of the treatment tympanitis of the embodiment of the present invention 10, first cleaned in ear with hydrogen peroxide, ear is dried with cotton swab A small amount of medicine is taken with small suction pipe after piece, is blown into ear, once a day, 3 days as one therapeutic course.

3 curative effect judging standards

Cure：Symptom all disappears, and ear functional activity recovers normal；

It is effective：Ear is stifled, tinnitus symptom disappears, and hearing is improved to normal；Pure tone test detection moral integrity leads difference within 10dB；Acoustic resistance Anti- inspection tympanogram is A type curves, and peak value is 0.3-1.5mm, and cochleostapedial reflex is drawn；Effectively：Ear is stifled, tinnitus symptom subtracts Gently, hearing is improved；Pure tone test detection conductance improves 10-15dB before relatively treating, but not up to normal, and acoustic impedance checks tympanum Tonogram is As type curves, and peak value is relatively normal relatively low.It is invalid：Clinical symptoms are checked and are not improved without improvement, items.

4 results

By the 2-3 treatment of the course for the treatment of, clinical efficacy is shown in Table 1.

The therapeutic effect of table 1

	Healing/example	Significantly/example	Effectively/example	Invalid/example	Total effective rate/%
						Curative effect	278	20	2	3	99.01

As can be seen from the above table, by the 2-3 treatment of the course for the treatment of, healing 278, notable 20, effective 2, invalid 3, always Up to 99.01%, illustrate the external used medicine of the treatment tympanitis of present invention offer has good curative effect to effective percentage.

Model case

Case 1：Lee X, man, 36 years old, office worker.

Private prosecution：Frequent discharging ear water over several years, today ear it is swollen cause headache, otalgia once used Western medicine and externally applied drug without obvious Effect.External auditory meatus eardrum regards unclear on inspection, is perforated at the point of eardrum six after cleaning, is diagnosed as otitis media suppurative.Give this hair Bright embodiment 5 is treated, and treats 2 courses for the treatment of, and the state of an illness is almost recovered, and further consultation is preferable, then 1 course for the treatment of of after treatment, and further consultation is fullyed recover from an illness More, follow-up is preferable so far.

Case 2：King X, man, 19 years old, student.

Private prosecution：Ear flowing water, otalgia several months, once with western medicine but less effective, recurrence today, and cause fever 39.0 ℃.External auditory meatus has a purulent secretion on inspection, and eardrum regards unclear, visible eardrum central perforation after cleaning, be diagnosed as it is suppurative in Otitis.3 courses for the treatment of are treated using the embodiment of the present invention 8, further consultation, recovery from illness, follow-up is not recurred for 1 year.

Case 3：Zheng XX, female, 40 years old, office worker.

Private prosecution：Flu causes auris dextra to be become deaf obturation before 10 days, Hearing, from sound enhancing, accompanies by tinnitus.Left drum on inspection Film is complete, and sense of slightly sinking, doctor trained in Western medicine is diagnosed as catarrhal otitis media.2 courses for the treatment of, the state of an illness five are treated using the embodiment of the present invention 7 Day is taken a turn for the better, and ear endocrine is significantly reduced, then treats recovery from illness after 1 course for the treatment of, and follow-up is not recurred after 2 years.

Case 4：Open XX, female, 29 years old, teacher.

Private prosecution：, there is pain in patient's first quarter moon cause left side external ear itch, do not take notice of, seven days presensations after being wiped with swab stick Pain is aggravated, and voluntarily buys the medicines such as amoxil capsule and detoxicating tablet of cow-bezoar orally, and curative effect is not good enough, feels within nearly 3 days auris dextra portion pain Acutely, night cannot fall asleep pain, and left duct oozes out purulent secretion with pain.Otitis externa and furuncle, external ear on inspection Anthorisma in road junction and duct, has and oozes out slurry sexual secretion, and late period limits into furuncle purulence, and secretion does not have mucus, really It is left otitis media,suppurative,acute to examine.Give the embodiment of the present invention 11 to be treated, treat 3 courses for the treatment of, the state of an illness is almost recovered, Further consultation is preferable, then 1 course for the treatment of of after treatment, further consultation, and recovery from illness, follow-up is preferable so far.

Case 5：Zheng XX, man, 23 years old, student.

Private prosecution：Binaural listening decline was found before 4 months, without obvious otagra, without purulent secretion, without heating, without evil The heart, vomiting, take the Zhou Houwu of Western medicine 2 and are clearly better in local hospital.Later lasting to occur, property is the same, and delay is not healed, gradually Aggravate.Not vertigo, distortion of commissure.Card its property tympanitis is diagnosed as after inspection.Since morbidity, spirit, diet and sleep are still Can, stool, urine is normal.Give the embodiment of the present invention 3 to be treated, treat 2 courses for the treatment of, the state of an illness is almost recovered, further consultation is preferable, then 1 course for the treatment of of after treatment, further consultation, recovery from illness, follow-up is not recurred after 1 year.

Case 6：Apply X, female, 31 years old, workman.

Private prosecution：Binaural listening declines the year before, and without suppurating, without heating, without Nausea and vomiting, without dizziness, vital sign is just Often.On inspection, bilateral auricle is symmetrical, and without deformity, without drawing pain, bilateral skin of external auditory canal has no purulent secretion logistics without redness Go out, eardrum is muddy, incorrect marking caves in, light cone areflexia, move degree slightly worse.Mastoid region is without obvious tenderness.It is diagnosed as chronic point Secreting property tympanitis.3 courses for the treatment of are treated using the embodiment of the present invention 12, further consultation, recovery from illness, follow-up is not recurred for 1 year.

Case 7：Money XX, man, 48 years old, peasant.

Private prosecution：There are ears without obvious inducement before a year and a half to suppurate, taken a turn for the better after treatment, but symptom is again after suffering from cold Recurrent exerbation, nearly X, exacerbation of symptoms, and feel that fester is more smelly, even band is courageous and upright, is decreased obviously with binaural listening.Not with head Dizzy, headache, without obvious tinnitus, dizziness, without facial numbness.Local hospital gives symptomatic treatment, unsatisfactory curative effect.Now through further inspection Look into, be diagnosed as " Cholesteatomatous Tympanitis.Give the embodiment of the present invention 6 to be treated, treat 2 courses for the treatment of, the state of an illness is almost recovered, Further consultation after first quarter moon, recovery from illness, follow-up is not recurred after 1 year.

Claims

1. a kind of external used medicine for treating tympanitis, it is characterised in that be prepared from by the raw material of following weight portion：The achene of Siberian cocklebur 20-50 parts, garden burnet 20-50 parts, meadowrueleaf corydalis root 20-50 parts, snake slough 20-50 parts, kiss-me 10-25 parts, Gaultheria 10-25 parts, Auricled Hedyotis Herb 5-15 parts, Verbena officinalis 5-15 parts, giant knotweed 8-25 parts, tassel flower 8-25 parts, Herba Andrographitis 5-15 parts, 10-25 parts of water wax gourd, water Arrowhead 5-15 parts, sargentodoxa cuneata 5-15 parts, caulis trachelospermi 5-15 parts, Japanses beauty-berry 8-20 parts, hedgehog skin 10-20 parts.

2. the external used medicine of tympanitis is treated as claimed in claim 1, it is characterised in that prepared by the raw material of following weight portion ：

3. the external used medicine of the treatment tympanitis as described in any one of claim 1 or 2, it is characterised in that its active component It is to extract to be prepared from using the ethanol of water extraction or 40-70% concentration expressed in percentage by volumes.

4. the external used medicine of tympanitis is treated as claimed in claim 3, it is characterised in that its active component is by following What method was prepared from：Whole raw material are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to raw material gross weight 6-12 times, each extraction time be 1-3 hour, merge extract solution, filter, relative density when filtrate is concentrated into 70-80 DEG C It is the clear cream of 1.15-1.20, obtains final product active component.

5. the external used medicine of tympanitis is treated as claimed in claim 3, it is characterised in that its active component is by following What method was prepared from：Whole raw material are taken, is extracted 2-3 times with 40-70% alcohol refluxs after mixing, each ethanol consumption is medicine 4-10 times of material total amount, extraction time is 1-4 hours, merges extract solution, is filtered, and filtrate is concentrated into relatively close at 70-80 DEG C The clear cream for 1.15-1.20 is spent, active component is obtained final product.

6. the external used medicine of tympanitis is treated in treatment as claimed in claim 3, it is characterised in that its active component is to pass through What following methods were prepared from：Whole raw material are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight 6-12 times of amount, each extraction time is 1-3 hours, merges extract solution, filtration, relative density when filtrate is concentrated into 70-80 DEG C It is the clear cream of 1.15-1.20, adds ethanol, make alcohol content for 40-60%, stand 12-24 hours, filtration, filtrate is concentrated into Relative density is the medicinal extract of 1.10-1.25 at 70-80 DEG C, obtains final product active component.

7. the external used medicine of tympanitis is treated as claimed in claim 3, it is characterised in that the external used medicine is by with lower section What method was prepared from：Gained active component is taken, hydrogen peroxide and peppermint oil is added, is homogenized with ultrasonic wave at 0-15 DEG C after mixing 20-40min, obtains final product；The consumption of the hydrogen peroxide is 40-80 times of active component weight；The consumption of the peppermint oil is activity The 10-50% of Ingredients Weight.

8. the external used medicine of the treatment tympanitis as described in any one of claim 1 or 2, it is characterised in that the external used medicine It is prepared by the following method：Whole medicinal materials being weighed by weight, being respectively put into ceramic pan, fire is fired with timber after adding a cover Burn to full charing, be well mixed after crushing, sterilizing is obtained final product.