CN106728071A - It is a kind of to treat medicine of gastric ulcer and preparation method thereof - Google Patents

It is a kind of to treat medicine of gastric ulcer and preparation method thereof Download PDF

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Publication number
CN106728071A
CN106728071A CN201611095412.3A CN201611095412A CN106728071A CN 106728071 A CN106728071 A CN 106728071A CN 201611095412 A CN201611095412 A CN 201611095412A CN 106728071 A CN106728071 A CN 106728071A
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parts
vitamin
medicine
gastric ulcer
auxiliary material
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不公告发明人
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Zhengzhou Lidiya Medicine Technology Co Ltd
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Zhengzhou Lidiya Medicine Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/245—Bismuth; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Abstract

The invention discloses a kind of medicine for treating gastric ulcer, it is made up of according to weight portion following raw material：Auxiliary material, anthocyanidin, alprazolam, oryzanol, moroxydine, metronidazole, stomach obtain happy, vitamin, procaine hydrochloride, ACV and ethanol solution.The present invention also disclosed the preparation method of the medicine.Raw material sources of the present invention are extensive, preparation process is simple, it is adaptable to large-scale industrial production；Vitamin, alprazolam, anthocyanidin, the stomach component such as must find pleasure in play synergy in the present invention, effective and thorough can kill helicobacter pylori and coordinate the effect of hydrochloric acid in gastric juice to dissolve and remove ulcer surface corruption layer, can with putrefaction-removing granulation-promoting, stimulate circulation, accelerate neoblastic growth, the effect of WeiDongLi Capsule is recovered in thorough repairing ulcer face, so as to reach the effect of radical cure gastric ulcer, using simple, treatment time is short and treatment cost is low, is difficult recurrence.

Description

It is a kind of to treat medicine of gastric ulcer and preparation method thereof
Technical field
The present invention relates to medicine pharmacy field, specifically a kind of medicine for treating gastric ulcer.
Background technology
Stomach trouble is the common disease for threatening human health, influence people to work, live, according to statistics every five men or every ten Just there is a patients with gastric disease in woman, and during morbidity, be often accompanied by stomach distending pain, poor appetite, nausea, gastrorrhagia, stomach and wear Hole, pylorus infraction, even result in canceration, the serious life that have impact on patient, health and work, until threat to life, and The incidence of disease of this disease is in the trend for rising year by year.Gastric ulcer is a kind of most common stomach trouble, and conventional treatment means are to use at present The medicines such as gel aluminum hydroxide, famotidine, cimetidine control acid；Using medicines such as Amoxicillin, gentamicins come anti-inflammatory； And gastric mucosal protection is carried out using happy electuary of enlightening etc..Because pathogenesis is complicated different, though above medicine respectively has its favourable Simultaneously, it is but undesirable in terms of eliminating symptom, promoting healing, reduction recurrence rate, can reach a constant current modulation using above means Effect, but generally require the time of 1-2 months, the course for the treatment of is long, and also needing to of having is hospitalized for observation, and some medicines also need to intravenous administration, There are various points for attention in therapeutic process well, therapeutic process trouble, expense is also higher, and this is just for patients with gastric disease brings puzzlement.
The content of the invention
It is an object of the invention to provide a kind of medicine for treating gastric ulcer, with asking for solving to propose in above-mentioned background technology Topic.
To achieve the above object, the present invention provides following technical scheme：
A kind of medicine for treating gastric ulcer, is made up of following raw material according to weight portion：Auxiliary material 2-5 parts, anthocyanidin 1-4 parts, Alprazolam 0.1-1 parts, oryzanol 0.5-3 parts, moroxydine 0.2-0.8 parts, metronidazole 8-13 parts, stomach obtain it is happy 10-16 parts, dimension life It is plain 6-15 parts, procaine hydrochloride 18-26 parts, ACV 2-6 parts and ethanol solution 15-25 parts.
As further scheme of the invention：Vitamin is the one of vitamin B1, vitamin B5, vitamin E and vitamin K Plant or various mixtures, auxiliary material is one kind of dextrin, lactose, starch, methylcellulose, carboxymethylcellulose calcium and stevioside Or several mixtures.
As further scheme of the invention：The mass fraction of ethanol is 40-60% in ethanol solution.
The preparation method of the medicine of the treatment gastric ulcer, comprises the following steps that：
Step one, weighs above-mentioned raw materials, gives over to standby；
Step 2, happy, vitamin, the general Shandong of hydrochloric acid are obtained by anthocyanidin, alprazolam, oryzanol, moroxydine, metronidazole, stomach Cacaine, ACV and ethanol solution are put into mixer, and mixer is stirred at normal temperatures, and auxiliary material is added while stirring, Auxiliary material is added after finishing, and mixer is stirred 45-70 minutes under 35-48 degrees Celsius with the rotating speed of 120-180rpm, and stirring terminates After be dried and desciccate be ground into 150-200 targeted fine powders, you can obtain finished product.
Compared with prior art, the beneficial effects of the invention are as follows：Raw material sources of the present invention extensively, fit by preparation process is simple For large-scale industrial production；Vitamin, alprazolam, anthocyanidin, the stomach component such as must find pleasure in play synergy in the present invention, Can it is effective and thorough kill helicobacter pylori and coordinate hydrochloric acid in gastric juice effect dissolve remove ulcer surface corruption layer, can with putrefaction-removing granulation-promoting, Stimulate circulation, accelerate neoblastic growth, the effect of WeiDongLi Capsule is recovered, so as to reach radical cure stomach in thorough repairing ulcer face The effect of ulcer, using simple, treatment time is short and treatment cost is low, is difficult recurrence.
Specific embodiment
The technical scheme of this patent is described in more detail with reference to specific embodiment.
Embodiment 1
A kind of medicine for treating gastric ulcer, is made up of following raw material according to weight portion：2 parts of auxiliary material, 1 part of anthocyanidin, A Pu 0.1 part of azoles logical sequence, 0.5 part of oryzanol, 0.2 part of moroxydine, 8 parts of metronidazole, stomach must find pleasure in 10 parts, 6 parts of vitamin, procaine hydrochloride 15 parts of 18 parts, 2 parts of ACV and ethanol solution.Vitamin is the mixture of vitamin B1 and vitamin B5, and auxiliary material is carboxylic first Base cellulose.
The preparation method of the medicine of the treatment gastric ulcer, comprises the following steps that：
Step one, weighs above-mentioned raw materials, gives over to standby；
Step 2, happy, vitamin, the general Shandong of hydrochloric acid are obtained by anthocyanidin, alprazolam, oryzanol, moroxydine, metronidazole, stomach Cacaine, ACV and ethanol solution are put into mixer, and mixer is stirred at normal temperatures, and auxiliary material is added while stirring, Auxiliary material is added after finishing, and mixer is stirred 50 minutes under 35 degrees Celsius with the rotating speed of 150rpm, and stirring is dried after terminating And desciccate is ground into 150 targeted fine powders, you can obtain finished product.
Embodiment 2
A kind of medicine for treating gastric ulcer, is made up of following raw material according to weight portion：3 parts of auxiliary material, 2 parts of anthocyanidin, A Pu 0.4 part of azoles logical sequence, 1.5 parts of oryzanol, 0.5 part of moroxydine, 10 parts of metronidazole, stomach must find pleasure in 12 parts, 9 parts of vitamin, hydrochloric acid Proca Because of 18 parts of 21 parts, 4 parts of ACV and ethanol solution.The mass fraction of ethanol is 45% in ethanol solution.
The preparation method of the medicine of the treatment gastric ulcer, comprises the following steps that：
Step one, weighs above-mentioned raw materials, gives over to standby；
Step 2, happy, vitamin, the general Shandong of hydrochloric acid are obtained by anthocyanidin, alprazolam, oryzanol, moroxydine, metronidazole, stomach Cacaine, ACV and ethanol solution are put into mixer, and mixer is stirred at normal temperatures, and auxiliary material is added while stirring, Auxiliary material is added after finishing, and mixer is stirred 58 minutes under 42 degrees Celsius with the rotating speed of 140rpm, and stirring is dried after terminating And desciccate is ground into 170 targeted fine powders, you can obtain finished product
Embodiment 3
A kind of medicine for treating gastric ulcer, is made up of following raw material according to weight portion：4 parts of auxiliary material, 3 parts of anthocyanidin, A Pu 0.8 part of azoles logical sequence, 2 parts of oryzanol, 0.6 part of moroxydine, 11 parts of metronidazole, stomach must find pleasure in 15 parts, Thioctic Acid part, procaine hydrochloride 23 parts of 24 parts, 5 parts of ACV and ethanol solution.Vitamin is vitamin K, and auxiliary material is the mixing of dextrin, starch and stevioside Thing.The mass fraction of ethanol is 52% in ethanol solution.
The preparation method of the medicine of the treatment gastric ulcer, comprises the following steps that：
Step one, weighs above-mentioned raw materials, gives over to standby；
Step 2, happy, vitamin, the general Shandong of hydrochloric acid are obtained by anthocyanidin, alprazolam, oryzanol, moroxydine, metronidazole, stomach Cacaine, ACV and ethanol solution are put into mixer, and mixer is stirred at normal temperatures, and auxiliary material is added while stirring, Auxiliary material is added after finishing, and mixer is stirred 60 minutes under 45 degrees Celsius with the rotating speed of 160rpm, and stirring is dried after terminating And desciccate is ground into 180 targeted fine powders, you can obtain finished product.
Embodiment 4
A kind of medicine for treating gastric ulcer, is made up of following raw material according to weight portion：5 parts of auxiliary material, 4 parts of anthocyanidin, A Pu 1 part of azoles logical sequence, 3 parts of oryzanol, 0.8 part of moroxydine, 13 parts of metronidazole, stomach must find pleasure in 16 parts, 15 parts of vitamin, procaine hydrochloride 26 25 parts of part, 6 parts of ACV and ethanol solution.Vitamin is the mixing of vitamin B1, vitamin B5, vitamin E and vitamin K Thing, auxiliary material is the mixture of dextrin, lactose, starch, methylcellulose, carboxymethylcellulose calcium and stevioside.
As further scheme of the invention：The mass fraction of ethanol is 40-60% in ethanol solution.
The preparation method of the medicine of the treatment gastric ulcer, comprises the following steps that：
Step one, weighs above-mentioned raw materials, gives over to standby；
Step 2, happy, vitamin, the general Shandong of hydrochloric acid are obtained by anthocyanidin, alprazolam, oryzanol, moroxydine, metronidazole, stomach Cacaine, ACV and ethanol solution are put into mixer, and mixer is stirred at normal temperatures, and auxiliary material is added while stirring, Auxiliary material is added after finishing, and mixer is stirred 65 minutes under 48 degrees Celsius with the rotating speed of 150rpm, and stirring is dried after terminating And desciccate is ground into 200 targeted fine powders, you can obtain finished product.
Comparative example
Except alprazolam is not contained, remaining component and preparation method of comparative example 1 are same as Example 2.
600 patients w ith peptic ulcer diseases of selection, men and women respectively accounts for half, and the oldest person 72 years old, age reckling 14 years old is random flat 1-6 groups are divided into, every group of 100 people take the product of embodiment 1-4 to 1-4 groups, 5 groups are taken with the product of comparative example 1 respectively, Existing product is taken to 6 groups, three times a day and warm water delivery service is used, 5 days is a course for the treatment of, continues 3 courses for the treatment of, controls curative effect Fruit is shown in Table 1.Treatment standard：Recovery from illness：Return to one's perfect health, recover normal completely；Effectively：Gastric ulcer takes a turn for the better, and returns to normal；Nothing Effect：Even deteriorate without being taken a turn for the better.
Table 1
Cure quantity (people) Effective quantity (people) Invalid quantity (people) Cure rate (%) Efficient (%)
1 group 92 6 2 92 98
2 groups 94 5 1 94 99
3 groups 95 4 1 95 99
4 groups 98 2 0 98 100
5 groups 23 38 39 23 61
6 groups 52 25 23 52 77
The cure rate and the efficient product for being significantly larger than comparative example 1 of embodiment 1-4 products are taken as can be seen from Table 1 And existing product, using effect is good.Points for attention during treatment：Take medicine on time, continuously take, must not interrupt.Adverse cardiac, During hepatitis, nephritis patient break out, pregnant woman etc. disable this medicine.It is anti-normal drug to occur urinating red, dizzy, tiredness during medication Should, belong to normal phenomenon, recover normal after drug withdrawal.It sometimes appear that anti-pain, also belongs to normal phenomenon after taking medicine 2-3 days, 5-6 days anti- Pain is died away.From starting to take medicine in one month, avoid and eat bamboo shoot, radish, wine, life, cold, sour, hard and irritable food.After healing, no The medicine being bad for the stomach is taken, not excessive consumption of alcohol is not eaten and drunk immoderately, and will not be recurred.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be in other specific forms realized.Therefore, no matter From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power Profit requires to be limited rather than described above, it is intended that all in the implication and scope of the equivalency of claim by falling Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each implementation method is only wrapped Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should Specification an as entirety, the technical scheme in each embodiment can also be formed into those skilled in the art through appropriately combined May be appreciated other embodiment.

Claims (4)

1. a kind of medicine for treating gastric ulcer, it is characterised in that be made up of according to weight portion following raw material：Auxiliary material 2-5 parts, cyanine It is plain 1-4 parts, alprazolam 0.1-1 parts, oryzanol 0.5-3 parts, moroxydine 0.2-0.8 parts, metronidazole 8-13 parts, stomach obtain happy 10- 16 parts, vitamin 6-15 parts, procaine hydrochloride 18-26 parts, ACV 2-6 parts and ethanol solution 15-25 parts.
2. it is according to claim 1 treatment gastric ulcer medicine, it is characterised in that the vitamin be vitamin B1, dimension One or more mixture of raw element B5, vitamin E and vitamin K, auxiliary material is dextrin, lactose, starch, Methyl cellulose The mixture of one or more of element, carboxymethylcellulose calcium and stevioside.
3. it is according to claim 1 and 2 treatment gastric ulcer medicine, it is characterised in that ethanol in the ethanol solution Mass fraction is 40-60%.
4. a kind of preparation method of the medicine for the treatment of gastric ulcer as described in claim 1-3 is any, it is characterised in that specific step It is rapid as follows：
Step one, weighs above-mentioned raw materials, gives over to standby；
Step 2, by anthocyanidin, alprazolam, oryzanol, moroxydine, metronidazole, stomach obtain happy, vitamin, procaine hydrochloride, ACV and ethanol solution are put into mixer, and mixer is stirred at normal temperatures, add auxiliary material, auxiliary material to add while stirring Enter after finishing, mixer is stirred 45-70 minutes under 35-48 degrees Celsius with the rotating speed of 120-180rpm, stirring is carried out after terminating Dry and desciccate is ground into 150-200 targeted fine powders, you can obtain finished product.
CN201611095412.3A 2016-12-02 2016-12-02 It is a kind of to treat medicine of gastric ulcer and preparation method thereof Withdrawn CN106728071A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022160323A1 (en) * 2021-01-31 2022-08-04 兰州大学 Application of nucleoside analogue in preparation of drugs for preventing or treating gastrointestinal diseases

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022160323A1 (en) * 2021-01-31 2022-08-04 兰州大学 Application of nucleoside analogue in preparation of drugs for preventing or treating gastrointestinal diseases

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