CN106727372A - A kind of preparation method of calcium lactate tablet - Google Patents
A kind of preparation method of calcium lactate tablet Download PDFInfo
- Publication number
- CN106727372A CN106727372A CN201611125774.2A CN201611125774A CN106727372A CN 106727372 A CN106727372 A CN 106727372A CN 201611125774 A CN201611125774 A CN 201611125774A CN 106727372 A CN106727372 A CN 106727372A
- Authority
- CN
- China
- Prior art keywords
- calcium lactate
- calcium
- tablet
- dextrin
- starch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 title claims abstract description 34
- 229960002401 calcium lactate Drugs 0.000 title claims abstract description 34
- 239000001527 calcium lactate Substances 0.000 title claims abstract description 34
- 235000011086 calcium lactate Nutrition 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title abstract description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 22
- 229920001353 Dextrin Polymers 0.000 claims abstract description 12
- 239000004375 Dextrin Substances 0.000 claims abstract description 12
- 229920002472 Starch Polymers 0.000 claims abstract description 12
- 235000019425 dextrin Nutrition 0.000 claims abstract description 12
- 239000008107 starch Substances 0.000 claims abstract description 12
- 235000019698 starch Nutrition 0.000 claims abstract description 12
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 9
- IMMUJNFDYJTOOR-UHFFFAOYSA-L calcium ethanol 2-hydroxypropanoate Chemical compound C(C)O.C(C(O)C)(=O)[O-].[Ca+2].C(C(O)C)(=O)[O-] IMMUJNFDYJTOOR-UHFFFAOYSA-L 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 11
- 238000004090 dissolution Methods 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 11
- 229960005069 calcium Drugs 0.000 description 11
- 239000011575 calcium Substances 0.000 description 11
- 229910052791 calcium Inorganic materials 0.000 description 11
- 238000002156 mixing Methods 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010006956 Calcium deficiency Diseases 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000020985 whole grains Nutrition 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000003217 Tetany Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229960003563 calcium carbonate Drugs 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002366 mineral element Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to technical field of medicine, a kind of preparation method of calcium lactate tablet is disclosed, be made up of the raw material of following percentage by weight：Calcium lactate 70~80%, dextrin 8~18%, starch 9~17%, magnesium stearate 0.1~0.5%, medicinal 95% appropriate amount of ethanol；Calcium lactate tablet disintegration time of the invention is shorter, and solubility is high, dissolution velocity is fast, bioavailability is high, in good taste, and stability is high.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, and in particular to a kind of preparation of calcium lactate tablet.
Background technology
Calcium is the participation that the most abundant essentially all of life processes of mineral element of people's in-vivo content are required to calcium.People
Body itself can not synthesize calcium, it is necessary to be absorbed from the external world.Various factors can produce various symptoms when calcium is taken in long-term not enough, can shadow
Ring to normal growth development.Calcium deficiency is before being not yet found, it is possible to it is grown and is produced harmful effect and is
Some chronic metabolic diseases of manhood hide some dangers for.
, it is necessary to carry out science under physician guidance during when dietary calcium insufficiency of intake or in the presence of other calcium deficiency high risk factors
Calcium agent is supplemented.This is the effective way for ensureing the enough calcium of intake.
Common calcium agent has：Calcium carbonate, calcium acetate, calcium lactate, calcium gluconae, calcium citrate, calcium monohydrogen phosphate.Wherein,
Calcium lactate is in good taste, decompose generation lactic acid, is a kind of good food Creta Preparata, and assimilation effect is better than inorganic calcium.Can use
In preventing and treating acalcicosis such as tetany, dysosteogenesis, rickets, and tuberculosis, the calcium of pregnant and women breast-feeding their children
Salt is supplemented.
And some present calcium lactate tablets to deposit disintegration time more long, solubility is not high and dissolution velocity is slow, so that raw
Thing utilization rate is low and the shortcomings of there is bad mouthfeel or stability not high.
The content of the invention
The present invention provides a kind of preparation method of calcium lactate tablet, and its effect is good, and disintegration time is short, and solubility is high, dissolving is fast
Degree is fast, bioavailability is high, in good taste, and stability is high.
To achieve the above object, technical scheme to be solved by this invention is：
Calcium lactate 70~80%
Dextrin 8~18%
Starch 9~17%
Magnesium stearate 0.1~0.5%
Medicinal 95% appropriate amount of ethanol
Further, calcium lactate tablet of the present invention, is made up of the raw material of following percentage by weight：
Calcium lactate 73~76%
Dextrin 12~17%
Starch 9~13%
Magnesium stearate 0.2~0.4%
Medicinal 95% appropriate amount of ethanol
Calcium lactate tablet of the invention can be prepared as follows：
（1）Dispensing：By the feed proportioning of above-mentioned percentage by weight.
（2）The preparation of adhesive：95% ethanol of recipe quantity is weighed, appropriate purified water is added, after being adjusted to 40% with alcohol meter
It is stand-by.
（3）Preprocessing raw material and auxiliary material：Calcium lactate, dextrin, starch cross 80 mesh sieves respectively, load standby in the dry polybag of cleaning
With.
（4）Mixing granulation：Calcium lactate, dextrin, starch are weighed by recipe quantity to be placed in high-speed mixing granulating machine, open stirring
Mixing 5 minutes, adds and prepares 40% ethanol while stirring after being well mixed, and cutting stirring granulation 5 minutes is made suitable particulate.
（5）Dry：Wet granular is uniformly divided in dry stainless steel pallet is cleaned, by stainless steel pallet from top to bottom
Successively be put into baking car in, by dry car push-in baking oven, dried in 70-80 DEG C 3-4 hour, it is cool to room temperature can receipts grain.
（6）It is whole grain, total mixed：After drying terminates, steam off treats that baking oven endoparticle is cooled to room temperature, will dry car and pulls out and dries
Case, pulls out drip pan from top to bottom, with the oscillating granulator whole grain for installing 14 mesh stainless steel mesh.The particle of grain, hard is rounded
Fatty acid magnesium is always mixed 15 minutes, discharging.
Specific embodiment
With reference to specific embodiment, the invention will be further described, but the invention is not limited in these embodiments.
Embodiment 1
Calcium lactate tablet, is made up of the raw material of following percentage by weight：
Calcium lactate 74.7%
Dextrin 12%
Starch 13%
Magnesium stearate 0.3%
Embodiment 2
Calcium lactate tablet, is made up of the raw material of following percentage by weight：
Calcium lactate 74.7%
Dextrin 14%
Starch 11%
Magnesium stearate 0.3%
Embodiment 3
Calcium lactate tablet, is made up of the raw material of following percentage by weight：
Calcium lactate 74.7%
Dextrin 15%
The % of starch 10
Magnesium stearate 0.3%
Embodiment 4
Calcium lactate tablet, is made up of the raw material of following percentage by weight：
Calcium lactate 74.2%
Dextrin 15%
The % of starch 10
Magnesium stearate 0.8%
Embodiment 5
Calcium lactate tablet, is made up of the raw material of following percentage by weight：
Calcium lactate 74.7%
Dextrin 16%
The % of starch 19
Magnesium stearate 0.3%
Analyzed by disintegration time limited, accelerated test data (data see the table below 1), the items such as discriminating, content of above-mentioned calcium lactate tablet
Testing index is in version in 2015《Chinese Pharmacopoeia》Acceptability limit in.
Following table is calcium lactate tablet prepared by each implementation item the following group point, in high temperature（60℃）, illumination (4500LX ±
500LX), the disintegration time limited for accelerating under the environment of relative humidity 50% and the result of the test of friability.
Knowable to from above-mentioned table, the calcium lactate tablet in embodiment 3, disintegration time is shorter, and stability is high.Can keep fast
The disintegration of speed, but can long-time stable and friability meets regulation, be to be more suitable for calcium lactate tablet and absorb the formula of storage constituting.Separately
Outward, this experiment also demonstrates magnesium stearate and is although conducive to Flow of Goods and Materials, but it is disintegrated it is unfavorable.
The above embodiments merely illustrate the technical concept and features of the present invention, and any those skilled in the art may
The Equivalent embodiments of equivalent variations are changed or are modified as using the technology contents of the disclosure above.But it is every without departing from this hair
Bright technical scheme content, any modification made to above example according to technical spirit of the invention or improve equivalent variations with
Remodeling, should all be included within the scope of the present invention.
Claims (2)
1. a kind of calcium lactate tablet, it is characterised in that prescription is constituted and each component content：
Calcium lactate 70~80%
Dextrin 8~18%
Starch 9~17%
Magnesium stearate 0.1~0.5%
Medicinal 95% appropriate amount of ethanol
Calcium lactate tablet is obtained according to above-mentioned prescription, specification is 0.25g, 1000 are made altogether.
2. the calcium lactate tablet according to claim l, it is characterised in that be made up of the raw material of following percentage by weight：
Calcium lactate 73~76%
Dextrin 12~17%
Starch 9~13%
Magnesium stearate 0.2~0.4%
Medicinal 95% appropriate amount of ethanol
Calcium lactate tablet is obtained according to above-mentioned prescription, specification is 0.25g, 1000 are made altogether.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611125774.2A CN106727372A (en) | 2016-12-09 | 2016-12-09 | A kind of preparation method of calcium lactate tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611125774.2A CN106727372A (en) | 2016-12-09 | 2016-12-09 | A kind of preparation method of calcium lactate tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106727372A true CN106727372A (en) | 2017-05-31 |
Family
ID=58877552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611125774.2A Pending CN106727372A (en) | 2016-12-09 | 2016-12-09 | A kind of preparation method of calcium lactate tablet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106727372A (en) |
-
2016
- 2016-12-09 CN CN201611125774.2A patent/CN106727372A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170531 |