CN106726957A - 一种除臭抑菌足粉及其制备方法 - Google Patents
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Abstract
本发明属于日化用品领域,具体涉及一种除臭抑菌足粉及其制备方法。本发明提供了一种除臭抑菌足粉,包括以下组分及其重量百分比:紫草素1‑5%、桂皮醛1‑3%、小蘖碱1‑3%、百秋李醇1‑3%、薄荷醇0.5‑1%、烷基糖苷1‑4%、茶皂素0.5‑1%、红没药醇1‑2%、除臭剂1‑8%、乙醇10‑20%和玉米粉50‑82%。本发明提供的除臭抑菌足粉不仅能有效改善足部多汗、防治脚臭,还能抑菌消炎、抗过敏,有效治疗足癣。同时本发明提供的除臭抑菌足粉性能温和、安全无刺激。
Description
技术领域
本发明属于日化用品领域,具体涉及一种除臭抑菌足粉及其制备方法。
背景技术
足癣,俗称“脚气”,由于真菌侵人足部表皮而致。一般发生于两侧足底及脚趾之间。古典医著《医宗金鉴外科心诀》对其症状有形象的描述:“此证由胃经湿热下注而生,脚丫破烂,其患甚小,其痒搓之不能解,必搓至皮烂,津腥臭水溃疡时,其痒方止,次日仍痒,经年不愈,极其缠绵。”足癣的发病率较高,尤其在我国的南方患病率高达80%以上。虽然算不上什么严重疾患,但痒起来的滋味也确实难受。有些患者由于用不洁的手抠脚趾,还会引起脚气感染,引发丹毒,也会影响患者在常的工作和学习。目前市面上用于治疗足癣的药物大多数是西药制剂,少数为中成药。西药虽有起效快的优点,但毒副作用相对较大,易产生耐药性,治标不治本;而中药制剂中含有的成分复杂,无效成分偏多,治疗针对性不强,给患者选择造成误区,且疗效不明显,甚至因其粉末中含有大量的杂质而易引起皮肤过敏症状。
中国专利申请CN106038453A公布了一种用于防治足癣的爽足粉,所述防治足癣的爽足粉包括以下重量份的原料:中药提取物5-20份、填充剂55-78份、表面活性剂2-6份、清凉剂0.05-1份、消炎抗敏剂0.1-2份、防腐剂0.05-0.2份;所述中药提取物为金钱草、龙胆草、五倍子、海螵蛸、肉桂、败酱草的醇提物和/或水提物。该发明爽足粉由中药原料经提取干燥而成,虽然有效成分的含量及生物利用度得到了提高,但是效果仍不理想。
中国专利申请CN105687021A公布了一种防治脚癣的爽足粉,所述爽足粉包括以下重量份的原料:中药组合物5-12份、填充剂50-75份、抗菌剂1-9份、表面活性剂2-6份、消炎抗敏剂0.5-2份、清凉剂0.1-1.5份;所述中药组合物为大风子、川椒、苦丁茶、藿香、当归的醇提物和/或水提物。该发明爽足粉使用方便,使用中延长了有效成分的作用时间,提高其疗效,但是生物利用率有待提高。
发明内容
为了解决现有技术中存在的问题,本发明的目的在于提供一种除臭抑菌足粉及其制备方法。本发明提供的除臭抑菌足粉不仅能有效改善足部多汗、防治脚臭,还能抑菌消炎、抗过敏,有效治疗足癣。
本发明提供了一种除臭抑菌足粉,包括以下组分及其重量百分比:
紫草素1-5%、桂皮醛1-3%、小蘖碱1-3%、百秋李醇1-3%、薄荷醇0.5-1%、烷基糖苷1-4%、茶皂素0.5-1%、红没药醇1-2%、除臭剂1-8%、乙醇10-20%和玉米粉50-82%。烷基糖苷购于广州健创生物科技有限公司,茶皂素购于湖南郎林生物制品有限公司,玉米粉购于广州赢特保健食品有限公司。
本发明配伍合理科学,各组分相互作用,协同起防治脚臭、抑菌消炎及抗过敏的作用。
进一步,所述的除臭抑菌足粉由以下组分及其重量百分比组成:
紫草素3%、桂皮醛2%、小蘖碱2%、百秋李醇2%、薄荷醇0.75%、烷基糖苷2.5%、茶皂素0.75%、红没药醇1.5%、除臭剂4.5%、乙醇15%和玉米粉66%。
进一步地,所述除臭剂为薰衣草油和桉叶油按重量比3:2组成。
同时,本发明还提供了一种除臭抑菌足粉的制备方法,包括以下步骤:
S1.将乙醇加热至60-70℃,边搅拌边加入紫草素、桂皮醛、小蘖碱、百秋李醇、薄荷醇、烷基糖苷、茶皂素、红没药醇及除臭剂,搅拌均匀,得溶液A;
S2.将步骤S1所得溶液A冷却至30-40℃,边搅拌边喷洒到玉米粉上,搅拌均匀,即得。
本发明提供的除臭抑菌足粉中紫草素(C16H16O5,CAS NO:517-89-5)具有抗炎、抗病原微生物的作用;桂皮醛(C9H8O,CAS NO:104-55-2)具有杀菌消毒、解热的作用;小蘖碱(C20H18O4,CAS NO:2086-83-1)具有抗菌消炎的作用;百秋李醇(C15H26O,CAS NO:5986-55-0)具有抑菌消毒的功效;薄荷醇(C10H20O,CAS NO:89-78-1)具有清凉、消炎的效果;红没药醇(C15H26O,CAS NO:515-69-5)具有消炎的作用;薰衣草油(CAS NO:8000-28-0)具有清热解毒、缓解疲劳及清新空气的作用;桉叶油(C10H18O,CAS NO:8000-48-4)具有杀菌、清新空气的作用。本发明中茶皂素、烷基糖苷、紫草素、桂皮醛、小蘖碱和百秋李醇发挥良好的协同效应,最大化发挥洗发杀菌抑菌、消炎止痒的功效,不再添加任何防腐剂。本发明配伍合理科学,各组分相互作用,协同起防治脚臭、抑菌消炎及抗过敏的作用。
与现有技术相比,本发明提供的除臭抑菌足粉不仅能有效改善足部多汗、防治脚臭,还能抑菌消炎、抗过敏,有效治疗足癣。同时本发明提供的除臭抑菌足粉性能温和、安全无刺激。
具体实施方式
下面通过具体实施例对本发明做进一步详细说明,这些实施例仅用于例证的目的,绝不限制本发明的保护范围。
实施例1一种除臭抑菌足粉
所述除臭抑菌足粉由以下组分及其重量百分比组成:
紫草素1%、桂皮醛1%、小蘖碱1%、百秋李醇1%、薄荷醇0.5%、烷基糖苷1%、茶皂素0.5%、红没药醇1%、薰衣草油0.6%、桉叶油0.4%、乙醇10%和玉米粉82%。
制备方法:
S1.将乙醇加热至65℃,边搅拌边加入紫草素、桂皮醛、小蘖碱、百秋李醇、薄荷醇、烷基糖苷、茶皂素、红没药醇、薰衣草油及桉叶油,搅拌均匀,得溶液A;
S2.将步骤S1所得溶液A冷却至35℃,边搅拌边喷洒到玉米粉上,搅拌均匀,即得。
实施例2一种除臭抑菌足粉
所述除臭抑菌足粉由以下组分及其重量百分比组成:
紫草素3%、桂皮醛2%、小蘖碱2%、百秋李醇2%、薄荷醇0.75%、烷基糖苷2.5%、茶皂素0.75%、红没药醇1.5%、薰衣草油2.7%、桉叶油1.8%、乙醇15%和玉米粉66%。
制备方法与实施例1类似。
实施例3一种除臭抑菌足粉
所述除臭抑菌足粉由以下组分及其重量百分比组成:
紫草素5%、桂皮醛3%、小蘖碱3%、百秋李醇3%、薄荷醇1%、烷基糖苷4%、茶皂素1%、红没药醇2%、薰衣草油4.8%、桉叶油3.2%、乙醇20%和玉米粉50%。
制备方法与实施例1类似。
对比例1一种除臭抑菌足粉
所述除臭抑菌足粉由以下组分及其重量百分比组成:
紫草素3%、桂皮醛2%、小蘖碱2%、百秋李醇2%、薄荷醇0.75%、烷基糖苷2.5%、茶皂素0.75%、红没药醇1.5%、薰衣草油2.25%、桉叶油2.25%、乙醇15%和玉米粉66%。
制备方法与实施例1类似。
与实施例2的区别在于,将薰衣草油与桉叶油的重量比3:2替换为1:1。
对比例2一种除臭抑菌足粉
所述除臭抑菌足粉由以下组分及其重量百分比组成:
紫草素3%、桂皮醛2%、小蘖碱2%、百秋李醇2%、冰片0.75%、烷基糖苷2.5%、茶皂素0.75%、红没药醇1.5%、薰衣草油2.7%、桉叶油1.8%、乙醇15%和玉米粉66%。
制备方法与实施例1类似。
与实施例2的区别在于,将薄荷醇替换为冰片。
试验例一、抑菌试验
1.试验材料:实施例1-3及对比例1-2制备的除臭抑菌足粉。
2.试验对象:菌株:白色念球菌、絮状表皮癣菌、羊毛状孢子菌、石膏样毛癣菌和红色毛癣菌。
3.试验内容:
1)将实施例1-3及对比例1-2制备的除臭抑菌足粉用水配置成浓度为1mg/mL的溶液;
2)白色念球菌用20-25℃培养24h的第二代新鲜培养物,用氯化钠注射液稀释;絮状表皮癣菌、羊毛状孢子菌、石膏样毛癣菌和红色毛癣菌均用20-25℃培养7天的斜面培养物,用氯化钠注射液将培养物洗下,振摇、过滤、镜检计孢子数、稀释,使菌液最终浓度为1×105cfu/mL,采用试管二倍稀释法测定最小抑菌浓度(MIC)和最小杀菌浓度(MBC)。
4.试验结果:细菌试验的最小抑菌浓度和最小杀菌浓度结果见表1。
表1除臭抑菌足粉抑菌效果测试表(MIC、MBC:μg/mL)
由表1知,本发明制备的除臭抑菌足粉抑菌效果较好。而对比例1-2制备的除臭抑菌足粉比实施例1-3制备的除臭抑菌足粉的抑菌效果差,说明本发明配伍合理、科学,各组分相互作用,协同起抑菌效果。
试验例二、感官评价
1.试验材料:实施例1-3及对比例1-2制备的除臭抑菌足粉。
2.试验对象:受试者100名,年龄20-40,男女各半。
3.试验对象:
将受试者分为5组,每组20人,记作实施例1-3组及对比例1-2组。分别使用实施例1-3及对比例1-2制备的除臭抑菌足粉泡脚,每日一次,使用一个月,使用人员对其使用情况给予感官评分。评分标准:采取10分制,1分最差,10分最好,分数越高效果越好越好。
4.试验结果:各除臭抑菌足粉的使用感官评价结果见表2。
表2除臭抑菌足粉的使用感官评价结果
由表2知,本发明提供的除臭抑菌足粉的感官评价较好。而对比例1-2制备的除臭抑菌足粉比实施例1-3制备的除臭抑菌足粉的感官评价差,说明本发明配伍合理、科学,各组分相互作用,协同起改善足部多汗、防治脚臭、消炎及清爽的作用。
Claims (4)
1.一种除臭抑菌足粉,其特征在于,包括以下组分及其重量百分比:
紫草素1-5%、桂皮醛1-3%、小蘖碱1-3%、百秋李醇1-3%、薄荷醇0.5-1%、烷基糖苷1-4%、茶皂素0.5-1%、红没药醇1-2%、除臭剂1-8%、乙醇10-20%和玉米粉50-82%。
2.如权利要求1所述的除臭抑菌足粉,其特征在于,由以下组分及其重量百分比组成:
紫草素3%、桂皮醛2%、小蘖碱2%、百秋李醇2%、薄荷醇0.75%、烷基糖苷2.5%、茶皂素0.75%、红没药醇1.5%、除臭剂4.5%、乙醇15%和玉米粉66%。
3.如权利要求1或2所述的除臭抑菌足粉,其特征在于,所述除臭剂为薰衣草油和桉叶油按重量比3:2组成。
4.如权利要求1-3任一所述的除臭抑菌足粉的制备方法,其特征在于,包括以下步骤:
S1.将乙醇加热至60-70℃,边搅拌边加入紫草素、桂皮醛、小蘖碱、百秋李醇、薄荷醇、烷基糖苷、茶皂素、红没药醇及除臭剂,搅拌均匀,得溶液A;
S2.将步骤S1所得溶液A冷却至30-40℃,边搅拌边喷洒到玉米粉上,搅拌均匀,即得。
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CN105687021A (zh) * | 2016-01-20 | 2016-06-22 | 广州丹奇日用化工厂有限公司 | 防治脚癣的爽足粉 |
CN105982988A (zh) * | 2015-01-27 | 2016-10-05 | 田旺富 | 一种巴土爽足粉 |
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CN105982988A (zh) * | 2015-01-27 | 2016-10-05 | 田旺富 | 一种巴土爽足粉 |
CN105687021A (zh) * | 2016-01-20 | 2016-06-22 | 广州丹奇日用化工厂有限公司 | 防治脚癣的爽足粉 |
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