CN106696293A - Method for manufacturing auditory ossicle with 3D printing technology - Google Patents
Method for manufacturing auditory ossicle with 3D printing technology Download PDFInfo
- Publication number
- CN106696293A CN106696293A CN201510470617.4A CN201510470617A CN106696293A CN 106696293 A CN106696293 A CN 106696293A CN 201510470617 A CN201510470617 A CN 201510470617A CN 106696293 A CN106696293 A CN 106696293A
- Authority
- CN
- China
- Prior art keywords
- phonophore
- auditory ossicle
- data
- printing
- middle ear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention provides a more accurate and more efficient method used for manufacturing auditory ossicle with a 3D printing technology and capable of improving surgical quality and safety. The method comprises steps as follows: firstly, high-resolution and high-contrast middle ear image data of a patient is acquired through CT (computed tomography), MRI (magnetic resonance imaging) or positron emission computer tomography; detailed pattern data of the auditory ossicle is extracted from the middle ear image data; a 3D model of the auditory ossicle is built by 3D computer software; hydroxyapatite and a photosensitive high-polymer material are adopted as raw materials, and the auditory ossicle is directly printed by a 3D printing device; or titanium powder particles are taken as the raw materials, a powdered metal material is sintered and solidified while a metallic matrix is locally molten with the adoption of high-energy laser beams, an auditory ossicle skeleton is produced and coated with a biological ceramic layer, and the auditory ossicle is formed; the printed auditory ossicle is compared with the 3D model data which is collected in advance, the auditory ossicle is qualified when the coincide ratio is 99.99%, and the auditory ossicle is subjected to fine repair again or reconstructed when the coincide ratio is lower than 99.99%.
Description
Technical field
The present invention relates to a kind of method that use 3D printing technique makes phonophore.
Background technology
Ear bones is the bone of minimum in human body, is also called phonophore, each three pieces of left and right ear.Ear bones is made up of malleus, incus and stapes,
Major part is occupy in attic, is connected composition auditory ossicular chain by means of ligament and joint.Manubrium mallei eardrum medial surface, positioned at mucous membrane
Between layer and fibrage.Stapes footplate is connected on oval window for annularligament.It is incus between hammer, stapes.Malleus, incus and
The arrangement mode that three pieces of stapes is as follows：Malleus is mutually connected on incus, and incus is mutually connected on stapes.I.e. stapes is connected and anvil with incus
Another section of bone is connected with malleus.Malleus transfers force to the oval window of cochlea.This three pieces of phonophores constitute a sequence mechanical system
System, the active force of sound is amplified by lever principle.Its main purpose is to realize the impedance in air and cochlea between liquid
Match somebody with somebody.The function of three pieces of bones is as follows：When sound wave in air reaches external auditory meatus end, cause pressure change on eardrum, eardrum is thus
Front and rear vibrations, replicate sound source, and are attached to the malleus on eardrum and also shake therewith, and vibrations reach stapes through incus again, and stapes is another
One end is connected with oval window, the motion of inner ear fluid can be caused during vibration, and then stimulate the sense of hearing receiver of inner ear.Three pieces of phonophores
Between arrangement just as lever system, with amplifying sound wave or reduce the function of sound wave.Can be via listening when sound is excessive or too small
Relative position between the control of bone flesh, three phonophores of adjustment, to adjust the energy number into inner ear.
Phonophore has very important status in the middle ear of people, and the patient of current dysaudia is that phonophore damage causes,
In the auditory rehabilitation field of medical profession, how to solve by the conductibility hearing caused by a variety of causes with sound transmission structure as major lesions
Decline, replacement operation is carried out with which kind of auditory ossicular chain reconstruction biomaterials and method, be one of emphasis direction of current otomicrosurgery research.
So far, for auditory ossicular chain shaping have titanium alloy ear bones, HA ear bones etc. because its good biocompatibility, stability with
And plasticity and using relatively broad in clinic.
But the reasons such as the complicated and individual appearance difference of phonophore fine structure, lesion type, can only select length, angle in art
Degree, profile artificial prosthesis proximate to it are implanted into after being subject to moulding, engraving.It is difficult with operation that said process not only increases operating time
Degree, and influence the transaudient efficiency of auditory ossicular chain.
Researcher of the invention it is also noted that at present 3D printing technique risen, also obtained preferably in medical field
Utilization.3D printing technique is considered as manufacturing revolution.The progress of development, production technology based on computer technology
With the appearance of new material, current 3D printing multiple fields acquisition rapid progress including including life science.In life
Thing medical domain, its evolution is replicated from the exploratory preoperative cast of early stage, and sclerotin is repaired to successful print conformal performance prosthese
Defect.
But it is still at present technological gap in this field of 3D printing phonophore, the skill without related patent and architectonical
Art document, and consider all to make by hand currently used for substituting the making of phonophore that patient damages, its efficiency and accuracy
It is all very low, therefore, reproduce and be badly in need of wanting a kind of more precise and high efficiency, the side of the making phonophore of surgical quality and security can be improved
Method.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of more precise and high efficiency, can improve the use of surgical quality and security
The method that 3D printing technique makes phonophore.
In order to solve the above technical problems, the technical scheme that the present invention is provided is：A kind of use 3D printing technique makes phonophore
Method, it comprises the following steps：
The first step, patient's high-resolution and high-contrast are obtained by CT, MRI or Positron Emission Computed Tomography
Middle ear image data；
Second step, extracts the detailed data type schema of phonophore from middle ear image data；
3rd step, is input into computer, and set up out phonophore by Computerized three-dimensional software by the detailed graph data of phonophore
3D models；
4th step, by the 3D model datas output of phonophore to 3D printing equipment；
5th step, using hydroxyapatite and photo sensitive polymeric materialses as raw material, is directly printed with 3D printing equipment and listens small
Bone；Or with titanium valve particle as raw material, printing precision is used for 20 μm of direct metal laser sintering pattern printer, in 3D
Under model data control, by using high energy laser beam, local melting metallic matrix sintering curing powder metal materials simultaneously,
And successively stack automatically, the phonophore skeleton of densification is ultimately generated, then form phonophore in surface spraying biological ceramic layer；
6th step, will print the phonophore for completing carries out 3D scannings；3D data are obtained, the data and the 3rd step that then will be obtained
In 3D model datas compare, coincide rate be judged at 99.99% it is qualified, less than above-mentioned identical rate then again refine or
Person remakes.
Preferably, in step 2, while the 3D data of the tissue on intratympanic phonophore periphery is acquired, it is then defeated
Enter 3D printer, using animal protein as raw material, perienchyma is printed, for aiding in doctor to be implanted into phonophore
With the size of inspection phonophore.
After using said structure, the invention has the advantages that：The phonophore that 3D printing technique is printed is being installed to user's body
Before body, it may also be used for surgical planning or Dummy modeling, i.e. operation consent " band adornment is had a dress rehearsal ".Surgeon can use will with them
The organ and position for implementing the same size of operation carry out operation training so that patient is in advance " having gully in the heart ".3D operation rehearsals
Operating time can be shortened, the problem of possible generation in art is found and predicted operation final result, while the tissue for printing can be fine
Replacement patient injury tissue, the precision than manual manufacture is higher, and efficiency is also higher, effectively prevent potential risk, improves
Surgical quality and security.
In sum, the invention provides a kind of more precise and high efficiency, the use 3D printing of surgical quality and security can be improved
The method of fabrication techniques phonophore.
Specific embodiment
A kind of method that use 3D printing technique makes phonophore, it comprises the following steps：
The first step, patient's high-resolution and high-contrast are obtained by CT, MRI or Positron Emission Computed Tomography
Middle ear image data；
Second step, extracts the detailed data type schema of phonophore from middle ear image data；
3rd step, is input into computer, and set up out phonophore by Computerized three-dimensional software by the detailed graph data of phonophore
3D models；
4th step, by the 3D model datas output of phonophore to 3D printing equipment；
5th step, using hydroxyapatite and photo sensitive polymeric materialses as raw material, is directly printed with 3D printing equipment and listens small
Bone；Or with titanium valve particle as raw material, printing precision is used for 20 μm of direct metal laser sintering pattern printer, in 3D
Under model data control, by using high energy laser beam, local melting metallic matrix sintering curing powder metal materials simultaneously,
And successively stack automatically, the phonophore skeleton of densification is ultimately generated, then form phonophore in surface spraying biological ceramic layer；
6th step, will print the phonophore for completing carries out 3D scannings；3D data are obtained, the data and the 3rd step that then will be obtained
In 3D model datas compare, coincide rate be judged at 99.99% it is qualified, less than above-mentioned identical rate then again refine or
Person remakes.
Preferably, in step 2, while the 3D data of the tissue on intratympanic phonophore periphery is acquired, it is then defeated
Enter 3D printer, using animal protein as raw material, perienchyma is printed, for aiding in doctor to be implanted into phonophore
With the size of inspection phonophore.
After using said structure, the invention has the advantages that：The phonophore that 3D printing technique is printed is being installed to user's body
Before body, it may also be used for surgical planning or Dummy modeling, i.e. operation consent " band adornment is had a dress rehearsal ".Surgeon can use will with them
The organ and position for implementing the same size of operation carry out operation training so that patient is in advance " having gully in the heart ".3D operation rehearsals
Operating time can be shortened, the problem of possible generation in art is found and predicted operation final result, while the tissue for printing can be fine
Replacement patient injury tissue, the precision than manual manufacture is higher, and efficiency is also higher, effectively prevent potential risk, improves
Surgical quality and security.
In the specific implementation, several main factors are critically important for the present invention：
Material and printing technique：It is presently used for the material predominantly titanium alloy and medical macromolecular materials of tissue reparation.Titanium
Alloy achieves certain progress in terms of the conformal reparation of large bulk bone tissue defect, development and printing precision with printing technique
Improve, it will played a role in fine reparation.With going deep into that the medical macromolecular materials of 3D printing are studied, it is soft in human body
Tissue repair aspect will also show the prospect of desirable.But macromolecular material printing technique is still in the starting stage, including
The problems such as biocompatibility, biological responding, degradation property, mechanical property, is to be resolved.In 3D printing and last handling process such as
What keeps the superperformance of moulding material, and the survival rate factor etc. of surface or internal cell is all beaten medical macromolecular materials 3D
Print proposes challenge.
2. medical imaging and CAD：3D printing must one by one decode the trickle shade in human body image, could be in meter
Model is built in calculation machine design document.In medical imaging, because different types of tissue or cell have similar phsyical density,
Cause it that similar shades of gray occurs in the picture, this shade obscured certainly will have a negative impact to printing precision.
That is, can not provide enough for 3D printing by the gradual change that complicated organization of human body is simply converted into " white ashes is black "
Information.These nondescript gray shades are to be converted to view data to implement a big technology barrier of 3D printing file format
Hinder.Can foretell, with the progress of digital audio-effect processing, people have set about in image zooming-out, increase resolution, post processing skill
The aspects such as art make great efforts tackling key problem, and this will provide technical support by significant human digit image information to be become apparent from, and will
Again speed up the pace of progress that 3D printing technique is converted to clinical practice.The complexity of organization of human body and otherness and human body diseases
Variation determine that 3D printing must high fit, ability therewith in all many-sides such as accurate duplications, virtual design, combinations of materials
Can be allowed to real clinical value.Current 3D printing technique can be used to prepare special size, shape, structure and work(
The biomaterial of energy and biological tissue, in study of disease generation, development mechanism, Development of Novel medical diagnosis on disease, treatment technology are ground
The aspects such as hair Novel medical device, medicine, medicine equipment, man-made organ still have many problems needs further to explore.Remove
It is many technical difficult outer, further relate to and face the social concern such as ethics dispute and blue law supervision.
The continuous maturation of 3D printing technique has expedited the emergence of the application demand in ENT ＆ HN Surgery Dept. field, and before beginning to show and being widely applied
Scape.Make it in teaching to the precise restoration of internal structure based on iconography data, dissect the application of the aspects such as training and surgical simulation
Develop rapidly；And the duplication true to nature of profile makes it may replace traditional system in terms of neck Maxillary region profile is without life form reparation
Operation mode；Especially in-situ immobilization achieves preliminary progress in terms of bone tissue reconstruction.
The present invention and embodiments thereof are described above, the description does not have restricted, actual implementation is not limited to
In this.If all in all one of ordinary skill in the art is enlightened by it, in the case where the invention objective is not departed from,
The method and embodiment similar to the technical scheme is designed without creative, protection scope of the present invention all should be belonged to.
Claims (2)
1. a kind of method that use 3D printing technique makes phonophore, it is characterised in that：It comprises the following steps：
The first step, the middle ear of patient's high-resolution and high-contrast are obtained by CT, MRI or Positron Emission Computed Tomography
Image data；
Second step, extracts the detailed data type schema of phonophore from middle ear image data；
3rd step, is input into computer, and the 3D of phonophore is set up out by Computerized three-dimensional software by the detailed graph data of phonophore
Model；
4th step, by the 3D model datas output of phonophore to 3D printing equipment；
5th step, using hydroxyapatite and photo sensitive polymeric materialses as raw material, phonophore is directly printed with 3D printing equipment；
Or with titanium valve particle as raw material, printing precision is used for 20 μm of direct metal laser sintering pattern printer, in 3D moulds
Under the control of type data, by using high energy laser beam, local melting metallic matrix sintering curing powder metal materials simultaneously, and
Automatically successively stack, ultimately generate the phonophore skeleton of densification, then form phonophore in surface spraying biological ceramic layer；
6th step, will print the phonophore for completing carries out 3D scannings；3D data are obtained, in the data and the 3rd step that then will obtain
3D model datas are compared, and it is qualified that the rate of coincideing is judged at 99.99%, less than above-mentioned identical rate then refine or weight again
New production.
2. the method that use 3D printing technique according to claim 1 makes phonophore, it is characterised in that：In step 2, together
When the 3D data of the tissue on intratympanic phonophore periphery is acquired, 3D printer is then input into, using animal protein
As raw material, perienchyma is printed, for aiding in doctor to be implanted into the size of phonophore and inspection phonophore.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510470617.4A CN106696293A (en) | 2015-08-05 | 2015-08-05 | Method for manufacturing auditory ossicle with 3D printing technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510470617.4A CN106696293A (en) | 2015-08-05 | 2015-08-05 | Method for manufacturing auditory ossicle with 3D printing technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106696293A true CN106696293A (en) | 2017-05-24 |
Family
ID=58929790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510470617.4A Pending CN106696293A (en) | 2015-08-05 | 2015-08-05 | Method for manufacturing auditory ossicle with 3D printing technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106696293A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109016067A (en) * | 2018-07-06 | 2018-12-18 | 华中科技大学 | Polylactic acid/calcium phosphate bioceramic preparation method suitable for selective laser sintering |
| CN109273092A (en) * | 2018-08-23 | 2019-01-25 | 温州医科大学附属第医院 | A method of preparing eardrum model and eardrum engraving model |
| CN110393590A (en) * | 2019-08-07 | 2019-11-01 | 天台县人民医院 | A kind of manufacturing method of 3D printing pelvis |
| WO2021232972A1 (en) * | 2020-05-19 | 2021-11-25 | 微智医疗器械有限公司 | Method for manufacturing electrode array forming die, shaping method, clamping tool, and medium |
| WO2021232973A1 (en) * | 2020-05-19 | 2021-11-25 | 微智医疗器械有限公司 | Method for manufacturing shaping mold and cortical electrical stimulator, shaping device for flexible electrode, and storage medium |
| CN114949355A (en) * | 2022-04-12 | 2022-08-30 | 宁波大学 | Auditory ossicle cartilage integrated auditory ossicle implant and manufacturing method thereof |
-
2015
- 2015-08-05 CN CN201510470617.4A patent/CN106696293A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109016067A (en) * | 2018-07-06 | 2018-12-18 | 华中科技大学 | Polylactic acid/calcium phosphate bioceramic preparation method suitable for selective laser sintering |
| CN109273092A (en) * | 2018-08-23 | 2019-01-25 | 温州医科大学附属第医院 | A method of preparing eardrum model and eardrum engraving model |
| CN109273092B (en) * | 2018-08-23 | 2021-08-06 | 温州医科大学附属第一医院 | Method for preparing tympanic membrane model and tympanic membrane carving reference model |
| CN110393590A (en) * | 2019-08-07 | 2019-11-01 | 天台县人民医院 | A kind of manufacturing method of 3D printing pelvis |
| WO2021232972A1 (en) * | 2020-05-19 | 2021-11-25 | 微智医疗器械有限公司 | Method for manufacturing electrode array forming die, shaping method, clamping tool, and medium |
| WO2021232973A1 (en) * | 2020-05-19 | 2021-11-25 | 微智医疗器械有限公司 | Method for manufacturing shaping mold and cortical electrical stimulator, shaping device for flexible electrode, and storage medium |
| CN114949355A (en) * | 2022-04-12 | 2022-08-30 | 宁波大学 | Auditory ossicle cartilage integrated auditory ossicle implant and manufacturing method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106696293A (en) | Method for manufacturing auditory ossicle with 3D printing technology | |
| CN103860293B (en) | A kind of personalized reversal design of full knee joint transposing prosthesis and manufacture method | |
| CN104173123B (en) | Quickly, reliable artificial bone prosthese preparation method | |
| CN105455925A (en) | Method for preparing bone repair implant on basis of selective laser melting technology | |
| CN105997306A (en) | Design method for filling porous grid structure in bone implantation body | |
| CN109172049A (en) | A kind of porous network structure orthopaedics based on the connection of laminated sheet bar repairs the designing and manufacturing method and implant of implant | |
| Ballo et al. | Digital workflow of auricular rehabilitation: a technical report using an intraoral scanner | |
| Mäkitie et al. | Three-dimensional printing for restoration of the donor face: A new digital technique tested and used in the first facial allotransplantation patient in Finland | |
| CN203988499U (en) | The net bag type mandibular bone implants of applying three-dimensional printing technique | |
| CN103750923A (en) | Artificial temporal-mandibular joint based on selective laser melting technology and manufacturing method thereof | |
| CN104473705A (en) | Head maxillofacial bone implant and method for quickly molding same | |
| CN104127265B (en) | String bag type lower jawbone implant applying three-dimensional printing technology | |
| CN103860295A (en) | Digital design and manufacturing method for knee joint tibia prosthesis | |
| CN111986310A (en) | Design method of mandible porous implant considering soft tissue attachment and bone growth and porous implant | |
| CN106580520A (en) | Method for producing mandibular implant with PEKK supporting and fixing unit and tissue engineering growth unit and implant | |
| Zheng et al. | Tissue transformation mold design and stereolithography fabrication | |
| Wang et al. | Prosthesis-guided implant restoration of an auricular defect using computed tomography and 3-dimensional photographic imaging technologies: A clinical report | |
| Šljivić et al. | Implemenation of FEM and rapid prototyping in maxillofacial surgery | |
| CN102451048B (en) | Complex-shaped gel-metal composite prosthesis and manufacturing method thereof | |
| Ruiters et al. | Three‐dimensional design of a geometric model for an ocular prosthesis in ex vivo anophthalmic socket models | |
| Jamayet et al. | New approach to 3D printing of facial prostheses using combination of open source software and conventional techniques: a case report | |
| CN114557797A (en) | Prosthesis for repairing segmental defect of lower jaw body and preparation method thereof | |
| CN207384356U (en) | A kind of titanium alloy rib cage replacement prosthesis | |
| Ciocca et al. | CAD–CAM construction of an auricular template for craniofacial implant positioning: A novel approach to diagnosis | |
| Singh et al. | Silicone prosthesis for a patient with unilateral ear defect: A Clinical case report |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170524 |
|
| WD01 | Invention patent application deemed withdrawn after publication |