CN1066941C - 一种治疗婴幼儿气滞腹痛、脘腹胀满和术后腹胀的口服液 - Google Patents

一种治疗婴幼儿气滞腹痛、脘腹胀满和术后腹胀的口服液 Download PDF

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CN1066941C
CN1066941C CN94110842A CN94110842A CN1066941C CN 1066941 C CN1066941 C CN 1066941C CN 94110842 A CN94110842 A CN 94110842A CN 94110842 A CN94110842 A CN 94110842A CN 1066941 C CN1066941 C CN 1066941C
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CN1106288A (zh
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盛义朝
汪文涛
崇巍
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HUNAN HANSEN PHARMACEUTICAL CO Ltd
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HUNAN HANSEN PHARMACEUTICAL CO Ltd
Wuma Pharmaceutical Co ltd Hu
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Abstract

一种治疗婴幼儿气滞腹痛、脘腹胀满和术后腹胀的口服液-四磨汤口服液，采用中药槟榔10-25重量%、木香10-25重量%、枳壳20-30重量%，乌药20-30重量%，取上述药材饮片提取芳香性成分，另存；将药渣加水煎煮，合并滤液，浓缩，加乙醇静置，滤取清液，减压回收乙醇，加水煮沸，过滤去渣，滤液中加入芳香性成分水液及适量辅料，滤过、分装、灭菌即得，具有剂量准确、疗效显著、质量稳定、口感良好，服用方便、适用于工业化规模生产的突出优点。

Description

一种治疗婴幼儿气滞腹痛、脘腹胀满和术后腹胀的口服液
本发明涉及人类生活必需的医疗保健药物，特别是应用我国优秀的中医药而成的纯中药制剂。
长期以来，在我国城乡很多地方将中药槟榔、木香、枳壳、乌药这四味中药临时研磨或者煮汤服用，对治疗婴幼儿气滞腹痛痞满不食及手术后病人具有满意的疗效，但手工研磨或煮汤存在剂量不易掌握，各味药比例难于确定、不能贮存、使用不便、不能工业化规模生产等缺点，中国专利90105957.9提供了一种“新型中药方便汤剂的制备方法”，是由中药加工成吸附剂和附着剂，经吸附烘干，分袋封装而成，但仍然存在着药效成分损失和使用不便之不足。
本发明之目的旨在提供一种剂量准确、疗效显著、质量稳定，口感良好，服用方便，适应于工业化规模生产的治疗婴幼儿气滞腹痛、脘腹胀满和术后腹胀的口服液-四磨汤口服液。
本发明的技术解决方案是采用中药槟榔、木香、枳壳、乌药按重量百分比配比：槟榔10-25％、木香10-25％、枳壳20-30％，乌药20-30％，取上述药材饮片、浸泡、加热提取芳香性成分，另存，将药渣加水煎煮1-3次，每次1-3小时，过滤，合并滤液，浓缩，加乙醇使含醇量为30-80％，静置10-30小时，沉淀，滤取清液，减压回收乙醇，加水煮沸10-30分钟，过滤去渣，滤液中加入前述的芳香性成分水液及适量辅料，调整总量、滤过、分装、灭菌即得。
〔功能主治〕：行气宽中、消肿止痛、主治婴幼儿气滞腹痛、脘腹胀满、啼哭难眠、不思饮食及手术后病人腹胀等症。
这种四磨汤口服液，药效学试验证明，能显著促进离体肠的运动，急性毒性试验结果为：最大耐受量为临床用药剂量的149倍，长期毒性试验经15天给药后，动物体重、血细胞、肝肾功能及心、肝、肾病理学检查与对照，无显著性差异。
本发明的新药，系传统方用现代科学方法提炼精制，加入适宜辅料制成口服液，特别适用于婴幼儿及手术后病人服用，具有起效迅速、无付作用。携带贮运方便，质量标准严格控制，剂量准确，服用方便的优点。

Claims (3)

1、一种治疗婴幼儿气滞腹痛、脘腹胀满和术后腹胀的口服液，其特征在于可按下述方法制备：取槟榔10-25重量％、木香10-25重量％、枳壳20-30重量％和乌药20-30重量％，浸泡、加热提取芳香性成分，另存，将药渣加水煎煮1-3次，过滤，合并滤液，浓缩，醇沉，静置，滤取清液，减压回收乙醇，加水煮沸，过滤，滤液中加入前述的芳香性成分水液及适量辅料，调整总量、滤过、分装、灭菌即得。
2、权利要求1的口服液，其特征在于药渣加水煎煮每次数1-3小时。
3、权利要求1的口服液，其特征在于加乙醇醇沉液浓度为30-80％，静置时间为10-30小时。
CN94110842A 1994-02-04 1994-02-04 一种治疗婴幼儿气滞腹痛、脘腹胀满和术后腹胀的口服液 Expired - Lifetime CN1066941C (zh)

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CN94110842A CN1066941C (zh) 1994-02-04 1994-02-04 一种治疗婴幼儿气滞腹痛、脘腹胀满和术后腹胀的口服液

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CN94110842A CN1066941C (zh) 1994-02-04 1994-02-04 一种治疗婴幼儿气滞腹痛、脘腹胀满和术后腹胀的口服液

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CN1066941C true CN1066941C (zh) 2001-06-13

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1061246C (zh) * 1997-04-16 2001-01-31 陶文元 一种治疗消化系统疾病的药物
CN102274369A (zh) * 2011-07-22 2011-12-14 湖南汉森制药股份有限公司 四磨汤口服凝胶剂及其制备方法
CN102380008B (zh) * 2011-11-06 2013-06-12 于向英 一种治疗肠粘连和粘连性肠梗阻的中药

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
《中医大辞典》方剂分册 1983.5.31 人民卫生出版社 *
《中医大辞典》方剂分册 1983.5.31 人民卫生出版社;《浙江中医杂志》22(2) 1987.2.28 干建华 加减四磨饮治疗胎粪性肠梗阻八例;《中医杂志》25(3) 1984.3.31 林峰 益气松粘汤治疗肠粘连5例报告;《吉林中医药》(1) 1987.1.31 孙朝晖 槟砂止痛汤治疗小儿腹痛 *
《中医杂志》25(3) 1984.3.31 林峰 益气松粘汤治疗肠粘连5例报告 *
《吉林中医药》(1) 1987.1.31 孙朝晖 槟砂止痛汤治疗小儿腹痛 *
《浙江中医杂志》22(2) 1987.2.28 干建华 加减四磨饮治疗胎粪性肠梗阻八例 *

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