CN106693205B - The online structure of riboflavin ultraviolet glue - Google Patents

The online structure of riboflavin ultraviolet glue Download PDF

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Publication number
CN106693205B
CN106693205B CN201611201341.0A CN201611201341A CN106693205B CN 106693205 B CN106693205 B CN 106693205B CN 201611201341 A CN201611201341 A CN 201611201341A CN 106693205 B CN106693205 B CN 106693205B
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ultraviolet
lamp
light
eye
dichroscope
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CN106693205A (en
Inventor
付威威
任华
陈奭
刘广兴
刘敏
董月芳
周哲
潘力
朱海龙
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Suzhou Institute of Biomedical Engineering and Technology of CAS
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Suzhou Institute of Biomedical Engineering and Technology of CAS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/062Photodynamic therapy, i.e. excitation of an agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0658Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661Radiation therapy using light characterised by the wavelength of light used ultraviolet

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  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

The present invention discloses a kind of riboflavin ultraviolet glue connection system, comprising: ultraviolet component comprising be displaced adjustable ultraviolet lamp;It is displaced adjustable positioning component comprising emergent light forms the first laser lamp and second laser lamp that joint is registered to eye focal area;The emergent light same light path of first laser lamp and ultraviolet lamp;Image collection assembly comprising the infrared camera of acquisition eye realtime graphic;Controller is communicatively connected to ultraviolet lamp, first laser lamp, second laser lamp and infrared camera respectively;Controller adjusts the displacement of positioning component and ultraviolet lamp according to eye realtime graphic is received in real time respectively, to be directed at ultraviolet light and the eye focal area of ultraviolet lamp sending in real time.Riboflavin ultraviolet glue connection system provided by the invention, ultraviolet lightseeking missile patient eyeball position can monitor and adjust ultraviolet light light intensity in real time to position eye optimal treatment position to guarantee optimal therapeutic effect.

Description

The online structure of riboflavin ultraviolet glue
Technical field
The present invention relates to cornea glue to join technical field, it is more particularly related to which a kind of riboflavin ultraviolet glue is online Structure.
Background technique
Keratoconus is that a kind of Central corneal progressive of unknown cause is thinning, the increase of Central corneal curvature progressive, leads The myopia and irregular astigmatism, a kind of serious cornea non-inflammatory disease for destroying visual function of height are caused, usually eyes are successively sent out Disease is apt to occur in adolescent patients, and is gradually in progress with advancing age, influences the eyesight and quality of life of patient.Keratoconus Usually involve eyes, but be in progress is in asymmetry more.With being constantly progressive for Clinics, child patient diagnostic rate mentions year by year It is high, it has also become one of current ophthalmology the most stubborn problem.
The basic principle of riboflavin ultraviolet glue connection treatment keratoconus is that photosensitizer riboflavin (i.e. vitamin B2) exists Under 370nm length ultraviolet light action, it is excited to triplet state, generates the active chalcogen based on singlet oxygen.Active chalcogen can To react with various molecules, to increase the mechanical strength of collagenous fibres, the stabilization of biological mechanics is maintained.
Traditional corneal cross-linking therapy is the epithelial tissue that Central corneal region is removed under art eye surface anesthesia, is with wavelength 370 ± 5nm, radiancy are the ultraviolet light 31min of 3mW/cm2, are equivalent to total photograph of 3.4J (anterior corneal surface 5.4J/cm2) Penetrate energy.Beam diameter is controlled as 9mm.
But due to needing local anaesthesia, eyeball involuntary trembling can occur in dopey situation at random, movement Range is trembleed within ± the 5mm put centered on the sclera center of circle.If not being adjusted to irradiation optical position, largely can Influence therapeutic effect, the failure even performed the operation.But doctor needs constantly to carry out riboflavin over the course for the treatment of at this time Adjunctive program can not be adjusted equipment.
Summary of the invention
Shortcoming present in view of the above technology, the present invention provide a kind of online structure of riboflavin ultraviolet glue, realize purple Outer lightseeking missile patient eyeball position can monitor and adjust ultraviolet light light intensity in real time to position eye optimal treatment position to protect Demonstrate,prove optimal therapeutic effect.
In order to realize these purposes and other advantages according to the present invention, the invention is realized by the following technical scheme:
The present invention provides a kind of online structure of riboflavin ultraviolet glue comprising:
Ultraviolet component comprising be displaced adjustable ultraviolet lamp;It is displaced adjustable positioning component comprising emergent light shape The first laser lamp and second laser lamp of eye focal area are registered at joint;The first laser lamp and the ultraviolet lamp Emergent light same light path;Image collection assembly comprising the infrared camera of acquisition eye realtime graphic;And controller, It is communicatively connected to the ultraviolet lamp, the first laser lamp, the second laser lamp and the infrared camera respectively;Its In, the controller adjusts the positioning component and the ultraviolet lamp according to the eye realtime graphic is received in real time respectively Displacement, to be directed at the ultraviolet light and eye focal area that the ultraviolet lamp issues in real time.
It preferably, further include the infrared lamp illuminated to assist the infrared camera acquisition eye realtime graphic, it is described Infrared lamp is communicatively connected to the controller.
It preferably, further include the white light illuminated to assist checking joint alignment eye focal area, it is described White light is communicatively connected to the controller.
Preferably, the infrared lamp and the white light are respectively facing at the joint.
Preferably, the ultraviolet component further includes beam shaping lens group, the first dichroscope and diaphragm;The purple The ultraviolet light that outer lamp issues passes through the beam shaping lens group and is shaped as flat top beam, after first dichroscope reflection It is projected across the diaphragm and reaches eye focal area;The emergent light of the first laser lamp is anti-with first dichroscope Penetrate light same light path.
Preferably, the ultraviolet component further includes being sequentially arranged in positioned at the ultraviolet lamp and the beam shaping lens group Between the second dichroscope and light intensity sensor, the light intensity sensor is communicatively connected to the controller;The ultraviolet lamp Ultraviolet light a part of sending passes through second dichroscope and reaches the light intensity sensor, another part through the described 2nd 2 The beam shaping lens group is reached to Look mirror reflection.
Preferably, described image acquisition component further includes between first dichroscope and the diaphragm Three dichroscopes;The reflected light same light path of the reflected light of the third dichroscope and first dichroscope;The third The input path of dichroscope is directed at the infrared camera.
It preferably, further include being connected to the control with the touch screen of touch operation, the touch panel communication for showing Device processed.
The present invention make less include it is following the utility model has the advantages that
1) the online structure of riboflavin ultraviolet glue provided by the invention is equipped with infrared camera and acquires eye realtime graphic, control Device adjusts the displacement of positioning component and ultraviolet lamp according to eye realtime graphic is received in real time respectively, to be directed at ultraviolet lamp hair in real time Ultraviolet light and eye focal area out, realize ultraviolet lightseeking missile patient eyeball position to position eye optimal treatment position It sets, improves the accuracy of eye optimal treatment position positioning;
2) ultraviolet light that beam shaping lens group is used to project ultraviolet lamp is flat top beam by Gauss beam reshaping;Flat-top Light beam passes through diaphragm after the reflection of the first dichroscope and projects arrival eye;
3) a part that light intensity sensor is used to acquire in ultraviolet light feeds back to controller, and controller is adjusted in real time according to feedback Save the ultraviolet lamp light intensity ultraviolet light stable with Output optical power;
4) thickness of the second dichroscope is adjusted, so that a part of ultraviolet light of light intensity sensor acquisition and arrival eye Another part ultraviolet light light intensity is identical, reduce as positioning caused by error and because conversion calculate and caused by light intensity regulating prolong Late;
5) third dichroscope is used to expand the visual field of infrared camera;
6) illumination of infrared lamp is to assist infrared camera to acquire eye realtime graphic, and the illumination of white light is to assist checking The positioning of positioning component and doctor add riboflavin operation.
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by this The research and practice of invention and be understood by the person skilled in the art.
Detailed description of the invention
Fig. 1 is the schematic diagram of the online structure of riboflavin ultraviolet glue of the present invention;
Fig. 2 is the communication scheme of the online structure of riboflavin ultraviolet glue of the present invention;
In figure:
11- ultraviolet lamp;The second dichroscope of 12-;13- light intensity sensor;21- first laser lamp;22- second laser lamp; 23- beam shaping lens group, the first dichroscope of 24-;25- diaphragm;31- infrared camera;32- third dichroscope;41- is red Outer lamp;42- white light;50- controller;60- touch screen.
Specific embodiment
Present invention will be described in further detail below with reference to the accompanying drawings, to enable those skilled in the art referring to specification text Word can be implemented accordingly.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein do not allot one or more The presence or addition of a other elements or combinations thereof.
As illustrated in fig. 1 and 2, the embodiment of the present invention provides a kind of online structure of riboflavin ultraviolet glue comprising ultraviolet component, position Move adjustable positioning component, image collection assembly and controller 50.Ultraviolet component includes being displaced adjustable ultraviolet lamp 11, Ultraviolet lamp 11 projects the ultraviolet light of cooperation core yellow extract for treating.Positioning component includes that emergent light formation joint is registered to eye lesion The first laser lamp 21 and second laser lamp 22 in region, the emergent light same light path of first laser lamp 21 and ultraviolet lamp 11.Image is adopted Collection component includes the infrared camera 31 for acquiring eye realtime graphic.Controller 50 is communicatively connected to ultraviolet lamp 11, first respectively Laser lamp 21, second laser lamp 22 and infrared camera 31.
In above embodiment, emergent light forms joint and is registered to eye focal area, refers to first laser lamp 21 It is overlapped with two cross focuses of second laser lamp 22 and overlapping position is directed at eye focal area, i.e. emergent light is overlapped at joint Place.Ultraviolet lamp 11, the unlatching of first laser lamp 21 and second laser lamp 22,11 emergent light light intensity magnitude of ultraviolet lamp are by control Device 50 controls.Controller 50 receives the eye realtime graphic that infrared camera 31 acquires.According to eye realtime graphic, controller 50 The displacement for adjusting positioning component and ultraviolet lamp 11 in real time respectively, so that at the joint of first laser lamp 21 and second laser lamp 22 It is directed at eye focal area, then emergent light can be directed at eye with the ultraviolet light that the ultraviolet lamp 11 of 21 same light path of first laser lamp issues Portion focal area determines that ultraviolet lighting is mapped to the optimum position of eye, realizes ultraviolet light real-time tracing patient's eyeball position.Cause This, there are joint is subsequent ultraviolet light and eye lesion between 22 emergent light of 21 emergent light of first laser lamp and second laser lamp The alignment in region provides preliminary alignment reference.Again because the eye realtime graphic that infrared camera 31 acquires feeds back to controller 50 It to adjust the displacement of ultraviolet lamp 11, positioning component in real time, and then realizes ultraviolet lightseeking missile patient eyeball position, improves eye The accuracy of optimal treatment position positioning.When treatment, first riboflavin is added dropwise to patient's eyes in doctor, is restarted provided by the invention The online structure of riboflavin ultraviolet glue, then ultraviolet lamp 11 is lighted, and carries out ultraviolet lighting treatment to eyes of patients focal area.Period, disease Human eye ball is mobile, and infrared camera 31 acquires eye realtime graphic, and controller 50 is according to eye realtime graphic, to patient's eyes disease Stove region is calculated relative to the deviation post at joint, and the instruction of the further output driving of controller 50 drives 11 He of ultraviolet lamp Positioning component moves respectively, so that being directed at the real-time eye disease of patient at the joint of first laser lamp 21 and second laser lamp 22 Stove region, i.e. the hot spot the center point of ultraviolet light is directed at the real-time eye focal area of patient always, to realize that ultraviolet light is automatic Patient's eyeball position is tracked, the accuracy of eye optimal treatment position positioning is improved.
In order to improve the accuracy of eye real time image collection, the present invention uses infrared camera 31.As for first laser Relative displacement between lamp 21 and second laser lamp 22, can be fixed, then joint is fixed, ultraviolet lamp 11 and positioning The relative displacement of component is fixed;It is also possible to adjust in real time, and meets emergent light and form joint, the present invention It is not specifically limited.
As another embodiment of the invention, the online structure of riboflavin ultraviolet glue further includes illumination to assist infrared photography The infrared lamp 41 of first 31 acquisition eye realtime graphic, infrared lamp 41 are communicatively connected to controller 50.Controller 50 controls infrared lamp 41 start and stop.The floor light of infrared lamp 41 improves the accuracy of 31 shooting, collecting eye realtime graphic of infrared camera.
As another embodiment of the invention, the online structure of riboflavin ultraviolet glue further includes that illumination is crossed with assisting checking The white light 42 of point alignment eye focal area, white light 42 are communicatively connected to controller 50.Controller 50 controls white light 42 Start and stop.The floor light of white light 42, to check that the joint of positioning component is directed at eye focal area and doctor's addition Riboflavin operation provides convenience.
When treatment, controller 50, which controls infrared lamp 41, to be lighted auxiliary infrared camera 31 and acquires eye realtime graphic, ultraviolet Lamp 11 lights sending ultraviolet light and is registered to patient's eyes focal area, cooperates core yellow extract for treating eye keratoconus;Treatment is interrupted, Controller 50 controls white light 42 and lights, and doctor adds riboflavin to patient under the illumination auxiliary of white light 42;Riboflavin adds Add end, controller 50 controls white light 42 and closes, and infrared lamp 41 and ultraviolet lamp 11 continue to light.Preferably, infrared lamp 41 It is respectively facing at joint with white light 42, floor light effect is preferable.
As another embodiment of the invention, ultraviolet component further includes beam shaping lens group 23, the first dichroic Mirror 24 and diaphragm 25;The ultraviolet light of ultraviolet lamp 11 pass through beam shaping lens group 23 be shaped as flat top beam, through the one or two to Look mirror 24 passes through diaphragm 25 and projects arrival eye after reflecting;First laser lamp 21 and the reflected light of the first dichroscope 24 are shared the same light Road.In the embodiment, beam shaping lens group 23 is used to ultraviolet light that ultraviolet lamp 11 projects be flat by Gauss beam reshaping Top light beam.The reflected light same light path of the emergent light of first laser lamp 21 and the first dichroscope 24, promote first laser lamp 21 with The emergent light same light path of ultraviolet light.
As another embodiment of the invention, ultraviolet component further include be sequentially arranged in it is whole positioned at ultraviolet lamp 11 and light beam The second dichroscope 12 and light intensity sensor 13, light intensity sensor 13 between shape lens group 23 are communicatively connected to controller 50; Ultraviolet light a part that ultraviolet lamp 11 issues passes through the second dichroscope 12 and reaches light intensity sensor 13, another part through the two or two It is reflected to Look mirror 12 and reaches beam shaping lens group 23.Light intensity sensor 13 acquires the purple that a part passes through the second dichroscope 12 Outer light simultaneously issues controller 50, controller 50 according to the feedback of light intensity sensor 13, can adjust in real time the light intensity of ultraviolet lamp 11 with The stable ultraviolet light of Output optical power.The thickness of the second dichroscope 12 is adjusted, so that a part that light intensity sensor 13 acquires Ultraviolet light is identical with another part ultraviolet light light intensity of eye is reached, and reduces the error as caused by positioning and because conversion calculates The delay of light intensity regulating caused by and.
As a preference of the present invention, the light end that goes out of first laser lamp 21 and ultraviolet lamp 11 is arranged straight down.When treatment, It being not easy to flow out for the ease of riboflavin and riboflavin is added dropwise to patient's eyes, then patient is preferably in lying status, then and first The light end that goes out of laser lamp 21 and ultraviolet lamp 11 is directed at patient's eyes focal area straight down, convenient for operation.
As another embodiment of the invention, image collection assembly further includes being located at the first dichroscope 24 and diaphragm Third dichroscope 32 between 25;The reflected light same light path of the reflected light of third dichroscope 32 and the first dichroscope 24; The input path of third dichroscope 32 is towards infrared camera 31.The realtime graphic of eye is reflected by third dichroscope 32 Into infrared camera 31, the acquisition of eye realtime graphic is realized.It is real-time that eye is acquired by the reflection of third dichroscope 32 Image expands the visual field of infrared camera 31.
As another embodiment of the invention, the online structure of riboflavin ultraviolet glue provided by the invention further includes for showing Show that the touch screen 60 with touch operation, touch screen 60 are communicatively connected to controller 50.Touch screen 60 can show first laser lamp 21 The images such as the eye realtime graphic of the coincidence of two cross focuses, the acquisition of 31- infrared camera with second laser lamp 22.Doctor is logical The convenient setting for the treatment of parameter, power, timing, duration etc. when treatment parameter includes treatment can be carried out by crossing touch screen 60.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed With.It can be applied to various suitable the field of the invention completely.It for those skilled in the art can be easily Realize other modification.Therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited In specific details and legend shown and described herein.

Claims (7)

1. a kind of online structure of riboflavin ultraviolet glue, characterized in that it comprises:
Ultraviolet component comprising be displaced adjustable ultraviolet lamp;
It is displaced adjustable positioning component comprising emergent light forms the first laser lamp that joint is registered to eye focal area With second laser lamp;The emergent light same light path of the first laser lamp and the ultraviolet lamp;
Image collection assembly comprising the infrared camera of acquisition eye realtime graphic;And
Controller is communicatively connected to the ultraviolet lamp, the first laser lamp, the second laser lamp and described red respectively Outer camera;
Wherein, the controller adjusts the positioning component and the purple according to the eye realtime graphic is received in real time respectively The displacement of outer lamp, to be directed at the ultraviolet light and eye focal area that the ultraviolet lamp issues in real time;
The ultraviolet component further includes beam shaping lens group, the first dichroscope and diaphragm;
The ultraviolet light that the ultraviolet lamp issues passes through the beam shaping lens group and is shaped as flat top beam, through the described 1st to The diaphragm is passed through after Look mirror reflection projects arrival eye focal area;
The reflected light same light path of the emergent light of the first laser lamp and first dichroscope.
2. the online structure of riboflavin ultraviolet glue as described in claim 1, which is characterized in that further include that illumination is described infrared to assist Camera acquires the infrared lamp of eye realtime graphic, and the infrared lamp is communicatively connected to the controller.
3. the online structure of riboflavin ultraviolet glue as claimed in claim 2, which is characterized in that further include that illumination is described to assist checking Joint is directed at the white light of eye focal area, and the white light is communicatively connected to the controller.
4. the online structure of riboflavin ultraviolet glue as claimed in claim 3, which is characterized in that the infrared lamp and the white light point Not towards at the joint.
5. the online structure of riboflavin ultraviolet glue as described in claim 1, which is characterized in that the ultraviolet component further includes successively setting In the second dichroscope and light intensity sensor between the ultraviolet lamp and the beam shaping lens group, the light intensity is passed Sensor is communicatively connected to the controller;
Ultraviolet light a part that the ultraviolet lamp issues passes through second dichroscope and reaches the light intensity sensor, another portion The reflection of second dichroscope described in lease making reaches the beam shaping lens group.
6. the online structure of riboflavin ultraviolet glue as described in claim 1, which is characterized in that described image acquisition component further includes position Third dichroscope between first dichroscope and the diaphragm;
The reflected light same light path of the reflected light of the third dichroscope and first dichroscope;The third dichroscope Input path be directed at the infrared camera.
7. such as the online structure of riboflavin ultraviolet glue of any of claims 1-6, which is characterized in that further include for showing With the touch screen of touch operation, the touch panel communication is connected to the controller.
CN201611201341.0A 2016-12-23 2016-12-23 The online structure of riboflavin ultraviolet glue Active CN106693205B (en)

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AU2019231257A1 (en) * 2018-03-05 2020-10-15 Avedro, Inc. System for eye tracking during eye treatment
CN109675204A (en) * 2019-01-22 2019-04-26 中国科学院苏州生物医学工程技术研究所 Ultraviolet light corneal cross-linking device
CN114306946A (en) * 2021-12-24 2022-04-12 艾视雅健康科技(苏州)有限公司 Medical device for applying light energy to eyes
CN114053021A (en) * 2021-12-24 2022-02-18 艾视雅健康科技(苏州)有限公司 Replaceable human body contact part for ophthalmic medical device and ophthalmic medical device
CN114272519A (en) * 2021-12-24 2022-04-05 艾视雅健康科技(苏州)有限公司 Method and device for adaptively adjusting position of light energy source of medical device

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