CN106693034A - Preparation method of pollution-free surgical dressing for sterilizing and stopping bleeding - Google Patents

Preparation method of pollution-free surgical dressing for sterilizing and stopping bleeding Download PDF

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Publication number
CN106693034A
CN106693034A CN201710189084.1A CN201710189084A CN106693034A CN 106693034 A CN106693034 A CN 106693034A CN 201710189084 A CN201710189084 A CN 201710189084A CN 106693034 A CN106693034 A CN 106693034A
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parts
amnion
vacuum
preparation
sterilizing
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罗静峰
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a preparation method of pollution-free surgical dressing for sterilizing and stopping bleeding. An amniotic membrane is treated by adopting a staged vacuum freeze drying technology, and is soaked in a traditional Chinese medicinal extract to prepare effective surgical dressing for sterilizing and stopping bleeding, which can be widely applied to treatment of wounds at various different degrees. Compared with the prior art, the prepared surgical dressing can be used for stopping bleeding, relieving pain and facilitating healing, has no side effects on human body, and is safe to use. The preparation method is simple and feasible, is low in cost, and is free from pollution.

Description

A kind of preparation method of free of contamination bactericidal haemostatic medical dressing
The present invention is application number：2015104682485, the applying date：2015-08-03, denomination of invention：A kind of bactericidal haemostatic Medical dressing preparation method divisional application.
Technical field
The invention belongs to field of medical materials, and in particular to a kind of preparation side of free of contamination bactericidal haemostatic medical dressing Method.
Background technology
In people's daily life, burn, scald occur often, the surface of a wound for causing various depth different, and easily cause Infection, causes various complication, and the development that thus be accordingly used in the effective medical dressing in the field is urgent problem.Amnion Because itself exclusive characteristic is paid close attention to by domestic and foreign scholars, amnion, from cytotrophoblast derivation, is embryo's duplicature Internal layer, is constituted by epithelium layer, basilar memebrane and without vascular stroma, and various collagens and layer adhesion egg are included in amnion In vain, fibronectin, glycosaminoglycan, hyaluronic acid etc..The exactly presence of these active materials, can promote sticking for epithelial cell Divide a word with a hyphen at the end of a line, induce epithelial differentiation, prevent epithelial apoptosis so that amnion serves as a kind of " transplantable basilar memebrane " to promote epithelialization. Additionally, also include many growth factors in amnion stroma, such as nerve growth factor (NGF), HGF (HGF), keratinocyte growth factor (KGF), transforminggrowthfactor-α (TGF- α), transforming growth factor-beta 1 (TGF-β 1), table Skin growth factor (EGF), basic fibroblast growth factor (bFGF) etc., can promote ocular epithelialization, mitigate inflammatory Reaction, suppression proliferation of fibrous tissue and new vessels are formed.Therefore, application of the amnion in ocular surface reconstruction in recent years is enjoyed and looked steadily Mesh.
The content of the invention
Prepare jointly a kind of effective bactericidal haemostatic it is an object of the invention to be combined with specific Chinese herbal medicine using amnion Medical dressing, to solve the above-mentioned problems in the prior art.
The present invention is adopted the following technical scheme that：A kind of preparation method of free of contamination bactericidal haemostatic medical dressing, including with Lower step：
(1) disinfection：After cleaning amnion with physiological saline, 2-3h in aqueous hydrogen peroxide solution is soaked in, then uses water Clean up；Amnion after sterilization is soaked in the 2~3h of the aqueous solution containing antibiotic；
(2) vacuum freeze drying stage by stage：By the amnion that step (1) is obtained be placed in 5~10g/L sodium alginate and 1~ After standing 10~15h in 5g/L hyaluronic acid solutions, vacuum freeze drying is carried out, first 2~3h of pre-freeze at 2~5 DEG C, then drops Temperature freezes 3~5h to -10~-15 DEG C, is continuing to cool to -20~-25 DEG C, freezes 3~5h, continuing to cool to -40~- 50 DEG C, 7~10h is freezed, control the moisture of amnion 5~10%；
(3) Chinese medicine is impregnated：The amnion that step (2) is obtained is immersed in Chinese medical extract, heating makes soaking temperature 30 ~50 DEG C, soak time is 10~15h；Wherein described Chinese medical extract is prepared by the following method and obtains：By following quality Part takes Chinese medicinal material, folium isatidis 8-10 parts, frutus cnidii 3-5 parts, pseudo-ginseng 3-5 parts, root of large-flowered skullcap 1-5 parts, dandelion 1-3 parts, chrysanthemum indicum 2-3 parts, honeysuckle 1-3 parts, 3-5 parts of bone pellet, Fructus Tribuli 6-8 parts, frankincense 2-3 parts, myrrh 5-10 parts, cloves 2-5 parts, safflower 1- 3 parts, rheum officinale 3-5 parts, Radix Glycyrrhizae 3-5 parts, rhizoma atractylodis 1-2 parts, add water to cook 1-2 hours, after the decoction liquor for obtaining is through ultrafiltration and nanofiltration, Purification of tcm liquid is obtained, medicinal alcohol and water mixing is subsequently adding, alcohol concentration is 65-70% in regulation solution, and is heated to 60-70 DEG C obtains described Chinese medical extract；
(4) it is vacuum dried：Amnion after step (3) treatment is carried out into vacuum drying treatment, temperature is 60~70 DEG C, is dried Time 2-4 hours；
(5) encapsulation sterilizing：Preserved at normal temperatures by the amnion after vacuum drying is packed, sterilized.
In a preferred embodiment of the present invention, the concentration of the aqueous hydrogen peroxide solution is 2~4g/L.
In a preferred embodiment of the present invention, described antibiotic is selected from penicillin, streptomysin, gentamicin A kind of or two kinds, its consumption is respectively 50 μ g/mL, 30 μ g/mL, 10 μ g/mL；
In a preferred embodiment of the present invention, the vacuum of the step (4) is 0.01-0.05MPa.
Medical dressing prepared by the present invention can be widely applied to the treatment of the various different degrees of surface of a wound, with prior art Compare, the present invention possesses following beneficial effect：
(1) by long term test research, find, using Vacuum Freezing ＆ Drying Technology stage by stage, amnion is being reduced step by step At a temperature of freeze-drying, staged cooling, can farthest remain its collagen and active factors composition so that amnion Composition do not destroyed, after testing, obtained medical dressing contains the μ g/mg of NTx 290.1 ± 1.0, III Collagen Type VI 356.8 ± 2.0 μ g/mg, the μ g/mg of type Ⅳ collagen 47.1 ± 1.0, the μ g/mg of HGF 71.2 ± 1.0, it is alkaline into fibre Dimension Porcine HGF 56.1 ± 1.0 μ g/mg；And the μ g/mg containing NTx 303.5 ± 5.3 in fresh amnion, III Collagen Type VI 384.2 ± 4.5 μ g/mg, the μ g/mg of type Ⅳ collagen 53.6 ± 1.7, the μ g/mg of HGF 89.9 ± 3.2, it is alkaline into fibre Dimension growth factor 7 1.1 ± 1.0 μ g/mg.
(2) by impregnating specific Chinese medicine preparation of the invention so that the amnion dressing for obtaining can more effectively stop blooding only Bitterly, promote healing, and human body is had no side effect, use safety.
(3) preparation method of the invention is simple and easy to apply, and low cost is pollution-free.
Specific embodiment
Technical solution of the present invention and its effect are further described below in conjunction with example.
Embodiment 1
(1) disinfection：After cleaning amnion with physiological saline, 2h, Ran Houyong in 2g/L aqueous hydrogen peroxide solutions are soaked in Water is cleaned up；Amnion after sterilization is soaked in the aqueous solution 3h containing 50 μ g/mL penicillin；
(2) vacuum freeze drying stage by stage：The sodium alginate and 5g/L that the amnion that step (1) is obtained is placed in into 8g/L are transparent After standing 10h in matter acid solution, vacuum freeze drying is carried out, first the pre-freeze 3h at 3 DEG C, then cools to -10 DEG C, freezes 5h, Continuing to cool to -20 DEG C, freezing 5h, continuing to cool to -50 DEG C, freezing 8h, controlling the moisture of amnion 7%；
(3) Chinese medicine is impregnated：The amnion that step (2) is obtained is immersed in Chinese medical extract, heating makes soaking temperature 30 DEG C, soak time is 15h；Wherein described Chinese medical extract is prepared by the following method and obtains：Chinese medicine is taken by following mass parts Medicinal material, 10 parts of folium isatidis, 3 parts of frutus cnidii, 4 parts of pseudo-ginseng, 2 parts of the root of large-flowered skullcap, 2 parts of dandelion, 2 parts of chrysanthemum indicum, 2 parts of honeysuckle, bone pellet 3 Part, 6 parts of Fructus Tribuli, 2 parts of frankincense, 6 parts of myrrh, 3 parts of cloves, 2 parts of safflower, 3 parts of rheum officinale, 3 parts of Radix Glycyrrhizae, 1 part of rhizoma atractylodis, add water to cook 2 hours, after the decoction liquor for obtaining is through ultrafiltration and nanofiltration, purification of tcm liquid is obtained, be subsequently adding medicinal alcohol and water mixing, regulation Alcohol concentration is 70% in solution, and is heated to 60 DEG C and obtains described Chinese medical extract；
(4) it is vacuum dried：Amnion after step (3) treatment is carried out into vacuum drying treatment, vacuum is 0.02MPa, temperature It is 70 DEG C to spend, 2 hours drying times；
(5) encapsulation sterilizing：Preserved at normal temperatures by the amnion after vacuum drying is packed, sterilized.
After testing, obtained medical dressing contains the μ g/mg of NTx 290.1, the μ g/mg of III Collagen Type VI 356.8, IV type The μ g/mg of collagen 47.1, the μ g/mg of HGF 71.2, the μ g/mg of basic fibroblast growth factor 56.1 are and fresh The composition of amnion is closer to, and illustrates that composition of the above-mentioned preparation method substantially not to amnion is damaged, the guarantor of high degree Its original appearance is held.
Obtained medical dressing is used for the surface of a wound, its influence (rate, time) to wound healing is tested.From the depth of animal The animal model that II degree skin scald models influence as evaluation dressing on wound healing.
Male Wistar rat is grouped at random, including normal healing group, commercially available conventional medical dressing group, the present invention are medical Dressing group, each group observe when phase point for wound after 3,7,14,21d, every group per when 10 animals of phase point.To be used after rat anesthesia success 80 DEG C of water-baths are scalded and cause within 15 seconds the depth II degree of rat back 10% skin scald (disease inspection section is confirmed), and 5ml is given through abdominal cavity after wound Physiological saline.In addition to normal healing group, each group is respectively with corresponding dressing flap coverage.Phase point surveys wound healing during each determination after wound Rate, first traces on onionskin the surface of a wound, then as template, homogeneous hard paper is cut into it is onesize, then Weigh weight in the balance, surface of a wound size is indirectly indicative with cardboard sheet weight.It is calculated as follows Wound healing rate：Wound healing rate (%)=(original surface of a wound area one do not heal surface of a wound area)/original surface of a wound area.Pathologic finding, understands wound healing quality, And healing time is determined according to wound healing situation.Result of the test shows, medical dressing group of the present invention, on surface of a wound recovery time Normal healing group, commercially available conventional medical dressing group are better than with the aspect of Wound healing rate two.
The present invention is not limited to the specific embodiment and explanation, and does not depart from and asked in right There are the main points of the invention asked, the technical field belonging to the present invention personnel of usual knowledge can carry out various modifications, and Protection scope of the present invention belonging to the deformation.

Claims (1)

1. a kind of preparation method of free of contamination bactericidal haemostatic medical dressing, it is characterised in that comprise the following steps：
(1) disinfection：After cleaning amnion with physiological saline, 2-3h in aqueous hydrogen peroxide solution is soaked in, is then cleaned with water Totally；Amnion after sterilization is soaked in the 2~3h of the aqueous solution containing antibiotic；
(2) vacuum freeze drying stage by stage：The amnion that step (1) is obtained is placed in the sodium alginate and 1~5g/L of 5~10g/L After standing 10~15h in hyaluronic acid solution, vacuum freeze drying is carried out, first 2~3h of pre-freeze at 2~5 DEG C, then lowers the temperature To -10~-15 DEG C, 3~5h is freezed, continuing to cool to -20~-25 DEG C, freeze 3~5h, continuing to cool to -40~-50 DEG C, 7~10h is freezed, the moisture of amnion is controlled 5~10%；
(3) Chinese medicine is impregnated：The amnion that step (2) is obtained is immersed in Chinese medical extract, heating makes soaking temperature 30~50 DEG C, soak time is 10~15h；Wherein described Chinese medical extract is prepared by the following method and obtains：Taken by following mass parts Chinese medicinal material, folium isatidis 8-10 parts, frutus cnidii 3-5 parts, pseudo-ginseng 3-5 parts, root of large-flowered skullcap 1-5 parts, dandelion 1-3 parts, chrysanthemum indicum 2-3 Part, honeysuckle 1-3 parts, 3-5 parts of bone pellet, Fructus Tribuli 6-8 parts, frankincense 2-3 parts, myrrh 5-10 parts, cloves 2-5 parts, safflower 1-3 Part, rheum officinale 3-5 parts, Radix Glycyrrhizae 3-5 parts, rhizoma atractylodis 1-2 parts, add water to cook 1-2 hours, after the decoction liquor for obtaining is through ultrafiltration and nanofiltration, Purification of tcm liquid is obtained, medicinal alcohol and water mixing is subsequently adding, alcohol concentration is 65-70% in regulation solution, and is heated to 60-70 DEG C obtains described Chinese medical extract；
(4) it is vacuum dried：Amnion after step (3) treatment is carried out into vacuum drying treatment, temperature is 60~70 DEG C, drying time 2-4 hours；
(5) encapsulation sterilizing：Preserved at normal temperatures by the amnion after vacuum drying is packed, sterilized；
The concentration of the aqueous hydrogen peroxide solution is 2~4g/L；
The vacuum of the step (4) is 0.01-0.05MPa.
CN201710189084.1A 2015-08-03 2015-08-03 Preparation method of pollution-free surgical dressing for sterilizing and stopping bleeding Pending CN106693034A (en)

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CN201510468248.5A Active CN104998294B (en) 2015-08-03 2015-08-03 A kind of preparation method of the medical dressing of bactericidal haemostatic
CN201710189022.0A Withdrawn CN106822981A (en) 2015-08-03 2015-08-03 A kind of preparation method of the bactericidal haemostatic medical dressing having no side effect
CN201710189084.1A Pending CN106693034A (en) 2015-08-03 2015-08-03 Preparation method of pollution-free surgical dressing for sterilizing and stopping bleeding
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CN107349335A (en) * 2017-06-13 2017-11-17 吉林省拓华生物科技有限公司 One kind carries medicine membrane film and its production and use
CZ2017846A3 (en) * 2017-12-27 2019-01-02 BioHealing k.s. A method for preparing amniotic membrane-based material and a material obtainable by this method
CN109045143A (en) * 2018-10-17 2018-12-21 佛山市妇幼保健院 A kind of manufacturing method of Chinese medicine perineum ice compress pad
CN112891062B (en) * 2021-02-26 2022-05-17 河南亚都实业有限公司 Multifunctional nanofiber-based composite hemostatic patch and preparation method thereof
CN114009541B (en) * 2021-11-03 2024-02-13 广西壮族自治区亚热带作物研究所（广西亚热带农产品加工研究所） Passion fruit tea and processing method thereof
CN114042185A (en) * 2021-11-18 2022-02-15 江苏洁乐医用敷料有限公司 Preparation method of medical dressing for sterilization and hemostasis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361552A (en) * 1980-09-26 1982-11-30 Board Of Regents, The University Of Texas System Wound dressing
CN1608681A (en) * 2003-10-17 2005-04-27 胡杰 Biological wound dressing
CN1943796A (en) * 2006-10-20 2007-04-11 关志广 The preparation method of the radiant crosslink porous reticular cells amnionic hydro gel dressing and its preparation method

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1088118A (en) * 1992-12-15 1994-06-22 吕平 Medical protective tectorial membrane for surfaces of wound
AUPQ196799A0 (en) * 1999-08-02 1999-08-26 Pinfold, Ann Method of preservation of amnion and uses thereof
JP5109030B2 (en) * 2005-07-25 2012-12-26 茂 木下 Sheet-like composition
US20140186461A1 (en) * 2012-09-10 2014-07-03 Alpha Tissue, Inc. Human Amniotic Membrane Lyophilized Grafts

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361552A (en) * 1980-09-26 1982-11-30 Board Of Regents, The University Of Texas System Wound dressing
CN1608681A (en) * 2003-10-17 2005-04-27 胡杰 Biological wound dressing
CN1943796A (en) * 2006-10-20 2007-04-11 关志广 The preparation method of the radiant crosslink porous reticular cells amnionic hydro gel dressing and its preparation method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
梁婧等: "人羊膜对创面愈合的促进作用", 《中国美容医学》 *

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CN106693033A (en) 2017-05-24
CN106822981A (en) 2017-06-13

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Application publication date: 20170524