CN106692886A - Traditional Chinese medicine composition for treating hepatolenticular degeneration and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hepatolenticular degeneration and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating hepatolenticular degeneration and a preparation method thereof, and relates to the technical field of treatment of the hepatolenticular degeneration. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 125 to 250 parts of rhizoma coptidis, 50 to 150 parts of radix salviae miltiorrhizae, 60 to 135 parts of spatholobus stems, 65 to 110 parts of radix et rhizoma rhei, 60 to 100 parts of rhizoma zedoariae, 60 to 120 parts of rhizoma curcumae longae, 60 to 150 parts of radix curcumae, 70 to 135 parts of rhizoma acori graminei and 150 to 250 parts of herba lysimachiae. Through the reasonable pathogenesis treatment based on syndrome differentiation, the nine traditional Chinese medicines are reasonably selected and proportioned; the addition proportion of each traditional Chinese medicine is optimized, so that the prepared traditional Chinese medicine composition has a good treatment effect on the hepatolenticular degeneration; the cure rate is high.
Description
Technical field
The present invention relates to the treatment technology field of hepatolenticular degeneration, it is specifically related to a kind of for treating the change of liver lenticular nucleus
Chinese medicine composition of property and preparation method thereof.
Background technology
Hepatolenticular degeneration (HLD), also known as Wilson diseases (WD), is autosomal recessive hereditary diseases, is hindered because copper is metabolized
Hinder cause copper in the tissue over-deposit and cause.Main pathological change is lenticular degeneration and cirrhosis, and clinical signs are
The limb tremor of progressive aggravation, myotonia, dyslalia, spirit change, cirrhosis and Kayser-Fleischer ring are formed.Its clinical table
Existing various, state of an illness complexity is refractory.The treatment such as doctor trained in Western medicine application penicillamine and zinc sulfate has maked decided progress, but controls effect and be difficult long
Consolidate, be difficult to control its organic growth.
Meanwhile, by treatment by Chinese herbs hepatolenticular degeneration, by development for many years, also occur in that more medicine can
Used for patient, for example, Chinese patent CN 105943749A disclose a kind of Chinese medicine for treating hepatolenticular degeneration and preparation side
Method, including following parts by weight each component：10~30 parts of oriental wormwood, 10~20 parts of stir-baked FRUCTUS GARDENIAE, 5~10 parts of rheum officinale, rhizoma alismatis 10~
30 parts, 10~20 parts of the root bark of tree peony, 20~40 parts of desmodium, 20~40 parts of Asiatic plantain, 10~20 parts of setose thistle, 10~20 parts of field thistle, fish
20~40 parts of raw meat grass, 15~30 parts of HERBA HEDYOTIS DIFFUSAE, 10~20 parts of the root of large-flowered skullcap, 10~20 parts of Herba Andrographitis.With clearing heat secreting bile, removing toxic substances row's copper
Effect, can effectively treat hepatolenticular degeneration, therapeutic effect is good, easy to use, and without obvious toxic-side effects.In addition, Chinese
Patent CN 1105055680A disclose a kind of Chinese medicine for treating hepatolenticular degeneration, and it is by the original of following weight proportion
Material medicinal material is prepared from：15 parts of light valve violet, 25 parts of Fructus meliae toosendan, 12 parts of calycanth, Pedicularis spicata l0 parts, 10 parts of Chinese neillia root,
15 parts of the fruit of glossy privet, 15 parts of coralhead plant stem with leaf.The Chinese medicine can safely and effectively treat hepatolenticular degeneration.
The content of the invention
In order to solve the above-mentioned technical problem, the present invention is based on gene molecule science of heredity, metabolism group traditional Chinese medical science pathogenesis, right
Hepatolenticular degeneration is furtherd investigate, right so as to obtain a kind of Chinese medicine composition for treating hepatolenticular degeneration
The cure rate of hepatolenticular degeneration is high.
To achieve these goals, the technical solution adopted in the present invention is as follows：
A kind of Chinese medicine composition for treating hepatolenticular degeneration, is obtained by the Chinese medicine material of following weight portion：
Preferably, for treating the Chinese medicine composition of hepatolenticular degeneration, it is obtained by the Chinese medicine material of following weight portion：
It is further preferred that the Chinese medicine composition for treating hepatolenticular degeneration, by the Chinese medicine material of following weight portion
It is obtained：
A kind of preparation method for treating the Chinese medicine composition of hepatolenticular degeneration is rapid as follows：
1) rheum officinale, curcuma zedoary and turmeric, are put into oven drying, are then crushed, cross 100 mesh sieves, fine powder is standby；
2), fine powder is merged with the coptis, root tuber of aromatic turmeric, calamus, desmodium and the red sage root, extracts secondary with 75% alcohol reflux, the
Once plus 10 times of 75% ethanol of weight, refluxing extraction 2h；Second plus 8 times of 75% ethanol of weight, refluxing extraction 1.5h；Close
And alcohol extract, filtration, reclaim ethanol；
3), the dregs of a decoction add 8 times of water of weight, decoct and extract 1h, and filtration staticly settles 48h, Aspirate supernatant, same to alcohol extract
Merging is concentrated under reduced pressure into the liquid extract that proportion is 1.10；
4), reticulate millettia adds water to cook extraction three times, and 10 times of water of weight are added for the first time, decocts 1.5h；Second and third time Jia 8
The water of times weight, decocts 1h；Merge Aqueous extracts, filtration staticly settles 48h, Aspirate supernatant, it is 1.10 to be concentrated under reduced pressure into proportion
Liquid extract；
5), combining step 3) and the 4) liquid extract that obtains, pharmaceutic adjuvant is added, then be made the various formulations in pharmacy.
Inventor is engaged in clinic and the over-carriage of research work 40, has to hepatolenticular degeneration etc. compared with in-depth study, hair
A person of good sense thinks that the etiology and pathogenesis of hepatolenticular degeneration are to emphasize asthenia in origin and asthenia in superficiality, specific as follows：
1st, native endowment deficiency is the basic reason for causing this sick
In congenital, cause patient is innate factor to this pathogeny, brains, liver, kidney is directly undermined, with the deficiency of liver-yin and kidney-yin, insufficiency of vital energy and blood
For this.The kidney being the origin of congenital constitution, and main bone gives birth to marrow, the brain being the reservoir of the marrow.Native endowment is not enough, and deficiency of kidney-essence, it is impossible to grow brains moistens foster
Edema with the liver involved, then deficiency of liver-blood, tendon and vessel is lost and is supported, then see limbs arrested anxious, contracture, walk with difficulty, it is clumsy in one's movement；Deficiecny of liver-YIN, positive simultaneously
High raw wind, wind-yang and up-boring, then see limb tremor, action increase, dyslalia etc..
2nd, wind, fire, phlegm, the stasis of blood are the key factors of morbidity
This sick the disease being located in the liver kidney, is related to brains, the heart, spleen, and characteristic of disease is asthenia in origin and asthenia in superficiality, with the deficiency of liver-yin and kidney-yin, insufficiency of vital energy and blood as this, liver
Wind, heat symptoms caused by an exopathgen, phlegm are turbid, hemostasis is mark.Disorder of emotion, eating and drinking without temperance, overstrain internal injury etc. can induce or aggravate this disease.Liver lenticular nucleus
Denaturation lesion is light from the beginning of, the state of an illness, and with the mark such as liver wind, heat symptoms caused by an exopathgen, phlegm-blood stasis as protrusion, late period then positive extreme exhaustion of QI will all be damaged, liver the congenital day after tomorrow
Spleen kidney multi viscera is involved, even there is the card that liver spleen renal failure loses.
Liver property happiness bar reaches and dislikes depression, is viscus attriguted to wind and wood, easy high movability.Liver also main feelings will, if because of disorder of emotion, hepatic depression
Knot, loses in catharsis, strongly fragrant then transformation of fire and occurrence of wind syndrome long, violates in brain on wind fire or walks to alter channels and collaterals, and see tremble, many clinics such as mental symptom
Performance；Also blood stasis can be caused because promoting circulation of blood is powerless, inverse spleen of violating can cause the dysfunction of the spleen in transport again.
The spleen being the foundation of acquired constitution, transporting has originally been short of, if again because of eating and drinking without temperance, benefit damages taste, transportation capabilities imbalance, qi and blood
Source is not enough, then deficiency of qi and blood is unable to Ru Yangjinmai.Insufficiency of the spleen to be then good for fortune not normal, it is impossible to promotes the production of body fluid spreading but accumulatively wet raise phlegm, the turbid illiteracy of phlegm
Cover clear key or it is interior disturb the mind, cause abnormal state of mind；Blockage of qi mechanism by phlegm, hematogenous blockage, phlegm is turbid to be combined with hemostasis, then into " accumulation ".
If pneumatic mistake is contained in the course of disease, lower and kidney water, in addition script deficiency of kidney-YIN, edema with the liver involved lose and the congenital reason such as support, cause liver
Kidney yin is lost more.Contained in kidney deficiency and liver, empty wind, it is excessive in passages through which vital energy circulates, then flutter breaking-out；Deficiency of kidney-essence, essence does not change marrow, and brain is hollow,
Then slow-witted and stupid；Disturbed on empty wind, clear key is damaged, then it is unfavorable to pronounce；Thanks to blood is few for essence, then see that skin color and luster is dark dim；God becomes homeless and supports then
Occur it is forgetful, dull, slow in reacting, cry and laugh by turns, without any apparent reason.
It has been recognised by the inventors that for the diagnosis and treatment based on an overall analysis of the illness and the patient's condition of hepatolenticular degeneration, main is to focus on Chinese and Western to close ginseng, and this pathogeny is in elder generation
My god, the disease being located in the liver kidney is related to brains, the heart, spleen.Dialectical and treatment center should be around kidney essense loss, deficiency of liver-blood.No matter the course of disease is long
Short, state of an illness weight all should constantly turn round and look at protect liver kidney.On the basis of not impariment of the liver kidney, the heresy of protrusion of first dispelling reduces it to healthy tendency as far as possible
Damage.It is nourishing liver and kidney after heresy is dispelled, supplying vital essence and marrow, symptom management progress.
The different phase of disease development, can occur each because producing different pathological products such as wind, fire, phlegm, stasis of blood etc. real evil
The outstanding behaviours of real example is planted, sample, weight, emergency should be distinguished.
On the basis of foregoing diagnosis and treatment, with reference to modern medical theory and research, Chinese medicine with it is upper and have it is original it
Place.Being caused the copper in body due to the disease can not normally be excreted, and cause the body chronic " copper poisoning ", therefore promote copper from courage
Juice is through stool discharge or increases the excretion of copper in urine, is also one of the indispensable link for treating this disease.Furthermore, it is necessary to especially
Focus on the importance of dietetic care, this patient should adhere to low copper diet, copper content food high of taking food is avoided as far as possible, forbid
Using copper cooker, the intake of copper is reduced for mitigating symptom, prevent disease development, maintain and consolidate curative effect, be very important
Effective measures.
The present invention is debated by the rational interpretation of the cause, onset and process of an illness and controlled, reasonable selection nine traditional Chinese medicines compatibility, preferably per the additional proportion of taste Chinese medicine,
So that the Chinese medicine composition for preparing, has good therapeutic effect to hepatolenticular degeneration, and cure rate is high.
Specific embodiment
The present invention is further illustrated with reference to embodiments.
Embodiment 1
First, a kind of liver beans curing capsule for treating hepatolenticular degeneration, active ingredient is former by the Chinese medicine of following weight portion
Material is obtained：
2nd, it is a kind of as follows for treating the preparation method step of the liver beans curing capsule of hepatolenticular degeneration：
1) rheum officinale, curcuma zedoary and turmeric, are put into oven drying, are then crushed, cross 100 mesh sieves, fine powder is standby；
2), fine powder is merged with the coptis, root tuber of aromatic turmeric, calamus, desmodium and the red sage root, extracts secondary with 75% alcohol reflux, the
Once plus 10 times of 75% ethanol of weight, refluxing extraction 2h；Second plus 8 times of 75% ethanol of weight, refluxing extraction 1.5h；Close
And alcohol extract, filtration, reclaim ethanol；
3), the dregs of a decoction add 8 times of water of weight, decoct and extract 1h, and filtration staticly settles 48h, Aspirate supernatant, same to alcohol extract
Merging is concentrated under reduced pressure into the liquid extract that proportion is 1.10；
4), reticulate millettia adds water to cook extraction three times, and 10 times of water of weight are added for the first time, decocts 1.5h；Second and third time Jia 8
The water of times weight, decocts 1h；Merge Aqueous extracts, filtration staticly settles 48h, Aspirate supernatant, it is 1.10 to be concentrated under reduced pressure into proportion
Liquid extract；
5), combining step 3) and the 4) liquid extract that obtains, liquid extract is spray-dried, add pharmaceutic adjuvant；
6), load capsule, the liver beans curing capsule for treating hepatolenticular degeneration is obtained, specification is 0.3g/.
3rd, for treating the clinical typical case of the liver beans curing capsule of hepatolenticular degeneration
Certain man, 23 years old, Anhui Province, people from Wangjiang County.Because of gradual glossolalia, four limbs shake is admitted to hospital for 5 years clumsy in one's movement.
It is ambiguous that patient will start to occur speech in the end of the year 2002, salivation, after gradually there are four limbs and do not shake independently, it is clumsy in one's movement, increase, in outer
Institute checks, looks into " the eyes K-F rings positive, blood biochemistry exception ", it is diagnosed as " and HLD ".Row splenectomy in 2004, and give liver protection drive
Symptom has taken a turn for the better after the western medical treatments such as copper, and period is voluntarily discontinued 1 year, and does not adhere to low copper diet, after occur four limbs shake plus
Weight, dysphoria in chestpalms-soles, restlessness, when have short-tempered, following the service Western medicine, symptom improve it is unobvious.Patient swallows still in the course of disease,
Dry halitosis, appetite is not good enough, and it is poor to sleep, and stool is dry, and urine is yellow.Family history is without special, the non-consanguineous marriage of father and mother.Have a medical check-up：It is refreshing clear,
Skin is black, glossolalia, and V degree of four limbs muscular strength, Muscle tensility increases in lead pipe sample, and bilateral knee jerk weakens, bilateral Babins2ki
Levy (+), refer to that nose owes accurate steady, alternate motion is clumsy again soon, eyes K-F rings (+), and abdomen is put down, under liver rib not and, shifting dullness (-),
Double lower limb pneumonedema, red tongue with a little fluid, tongue is few, veins string.Laboratory examination：1. blood routine：WBC 6.17×109/ L, RBC 4.23 ×
1012/ L, Hb 132g/L, PLT 132 × 109/L.2. hepatic and renal function：Normally.3. CER：0.09g/L.5. blood Cu 3.84
μm ol/L, the unit of activity of CuO-2 layer 0.05, urine copper 530.11 μ g/24h.6. eyes K-F rings (+).7. B ultrasonic shows：Liver beans hepatopathy,
Ephrosis.
Dialectical to belong to the deficiency of liver-yin and kidney-yin, patient is not enough because of native endowment, deficiency of kidney-essence, it is impossible to grow brains, moistens nourishing the liver wood, then
Liver blood (the moon) is not enough, and tendon and vessel is lost and supported, then see four limbs shake, clumsy in one's movement；Deficiecny of liver-YIN, the high raw wind of sun, wind-yang and up-boring is then shown in
Work increases, speech is ambiguous etc..Because of disorder of emotion, stagnation of liver qi is lost in catharsis, strongly fragrant then to change fire long, and perverse and unreasonable manner violates spleen, spleen can be caused again
Lose and be good for fortune, therefore the symptom such as poor, salivation of visible short-tempered, dry halitosis, appetite, red tongue with a little fluid, tongue are few, veins string is also liver kidney yin
Void as.
Control with nourishing liver and kidney, educate the moon and relieve dizziness, high fever, infantile convulsions, epilepsy, etc..Then using the treatment of liver beans curing capsule.Continuously take 2 weeks, symptom is clearly better,
Dysphoria in chestpalms-soles, dry, halitosis subtract greatly, and without restlessness, sleep is peaceful, and the shake of two hand tremors also has mitigation.
Continuation is taken 4 weeks by original side, and symptom continues to take a turn for the better, and dysphoria in chestpalms-soles, salivation disappears, and lower limb shake and glossolalia are bright
Aobvious to improve, on foot steadily, two hand tremors are slight, hold chopsticks and write and write flexible earlier above.Two are examining check blood picture, hepatic and renal function just
Often.Three examine after one month, and two hand tremors disappear, and write that font is carefully and neatly done, and speech is more visible, flexible movements, receive that dormancy is good, and two is just smooth.
After treatment is discontinued after three months.Follow-up half a year is without recurrence.
Embodiment 2
Preparation method is with embodiment 1.
Embodiment 3
Preparation method is with embodiment 1.
Embodiment 4
Preparation method is with embodiment 1.
Embodiment 5
Preparation method is with embodiment 1.
Above content is only to design example and explanation of the invention, affiliated those skilled in the art
Various modifications or supplement are made to described specific embodiment or is substituted using similar mode, without departing from invention
Design or surmount scope defined in the claims, protection scope of the present invention all should be belonged to.
Claims (4)
1. a kind of Chinese medicine composition for treating hepatolenticular degeneration, it is characterised in that by the Chinese medicine material of following weight portion
It is obtained：
2. it is used to treat the Chinese medicine composition of hepatolenticular degeneration as claimed in claim 1, it is characterised in that by following weight
The Chinese medicine material of part is obtained：
3. it is used to treat the Chinese medicine composition of hepatolenticular degeneration as claimed in claim 2, it is characterised in that by following weight
The Chinese medicine material of part is obtained：
4. a kind of method for preparing the Chinese medicine composition as described in claim 1 or 2 or 3, it is characterised in that step is as follows：
1) rheum officinale, curcuma zedoary and turmeric, are put into oven drying, are then crushed, cross 100 mesh sieves, fine powder is standby；
2), fine powder is merged with the coptis, root tuber of aromatic turmeric, calamus, desmodium and the red sage root, extracts secondary with 75% alcohol reflux, for the first time
Plus 10 times of 75% ethanol of weight, refluxing extraction 2h；Second plus 8 times of 75% ethanol of weight, refluxing extraction 1.5h；Merge alcohol
Ethanol is reclaimed in extract, filtration；
3), the dregs of a decoction add 8 times of water of weight, decoct and extract 1h, filtration, staticly settle 48h, and Aspirate supernatant merges with alcohol extract
It is concentrated under reduced pressure into the liquid extract that proportion is 1.10；
4), reticulate millettia adds water to cook extraction three times, and 10 times of water of weight are added for the first time, decocts 1.5h；Second and third time plus 8 times of weights
The water of amount, decocts 1h；Merge Aqueous extracts, filtration staticly settles 48h, and Aspirate supernatant is concentrated under reduced pressure into the stream that proportion is 1.10
Medicinal extract；
5), combining step 3) and the 4) liquid extract that obtains, pharmaceutic adjuvant is added, then be made the various formulations in pharmacy.
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| CN (1) | CN106692886A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109224038A (en) * | 2018-12-06 | 2019-01-18 | 河南省中医药研究院 | A kind of Chinese medicine composition of the evodia rutaecarpa containing guiding drug and its preparation method and application for treating obstruction of collaterals by blood stasis type liver fibrosis |
| CN113456781A (en) * | 2021-07-28 | 2021-10-01 | 安徽中医药大学第一附属医院(安徽省中医院) | Traditional Chinese medicine composition for treating kidney-type hepatolenticular degeneration and preparation method thereof |
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| 徐健: "鲍远程治疗肝豆状核变性的学术特点", 《中医药临床杂志》 * |
| 茜雪PRINCE: "肝豆状核变性中医诊疗指南", 《HTTP://WWW.360DOC.COM/DOCUMENT/15/0802/09/9078473_488870117.SHTML》 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109224038A (en) * | 2018-12-06 | 2019-01-18 | 河南省中医药研究院 | A kind of Chinese medicine composition of the evodia rutaecarpa containing guiding drug and its preparation method and application for treating obstruction of collaterals by blood stasis type liver fibrosis |
| CN109224038B (en) * | 2018-12-06 | 2021-04-20 | 河南省中医药研究院 | Traditional Chinese medicine composition containing channel-inducing medicine evodia rutaecarpa for treating blood stasis collateral blocking type hepatic fibrosis and preparation method and application thereof |
| CN113456781A (en) * | 2021-07-28 | 2021-10-01 | 安徽中医药大学第一附属医院(安徽省中医院) | Traditional Chinese medicine composition for treating kidney-type hepatolenticular degeneration and preparation method thereof |
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Application publication date: 20170524 |