CN106692752A - Traditional Chinese medicine composition for treating cramp - Google Patents
Traditional Chinese medicine composition for treating cramp Download PDFInfo
- Publication number
- CN106692752A CN106692752A CN201611249794.0A CN201611249794A CN106692752A CN 106692752 A CN106692752 A CN 106692752A CN 201611249794 A CN201611249794 A CN 201611249794A CN 106692752 A CN106692752 A CN 106692752A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- parts
- medicine composition
- cramp
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 69
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- 208000007101 Muscle Cramp Diseases 0.000 claims description 28
- 239000002775 capsule Substances 0.000 claims description 23
- 244000052363 Cynodon dactylon Species 0.000 claims description 22
- 241000212321 Levisticum Species 0.000 claims description 22
- 241000195947 Lycopodium Species 0.000 claims description 22
- 239000000706 filtrate Substances 0.000 claims description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 239000012467 final product Substances 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000000377 silicon dioxide Substances 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 4
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- 239000000314 lubricant Substances 0.000 claims description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 239000003826 tablet Substances 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- 229920000881 Modified starch Polymers 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 241000205585 Aquilegia canadensis Species 0.000 claims 5
- 241000165940 Houjia Species 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 13
- 229940079593 drug Drugs 0.000 abstract description 8
- 241000756258 Aristida stricta Species 0.000 abstract 1
- 235000014716 Eleusine indica Nutrition 0.000 abstract 1
- 241000245240 Lonicera Species 0.000 abstract 1
- 241000195954 Lycopodium clavatum Species 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 210000002435 tendon Anatomy 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 241001570521 Lonicera periclymenum Species 0.000 description 17
- 208000002193 Pain Diseases 0.000 description 8
- 210000003205 muscle Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000004087 circulation Effects 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 208000002740 Muscle Rigidity Diseases 0.000 description 3
- 231100000862 numbness Toxicity 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010033372 Pain and discomfort Diseases 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 210000003371 toe Anatomy 0.000 description 2
- 241000351450 Adiantum flabellulatum Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241001254604 Angelica pubescens Species 0.000 description 1
- 206010006956 Calcium deficiency Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 244000167230 Lonicera japonica Species 0.000 description 1
- 241000927897 Lycopodium japonicum Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010037742 Rabies Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 206010044684 Trismus Diseases 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000004227 calcium gluconate Substances 0.000 description 1
- 229960004494 calcium gluconate Drugs 0.000 description 1
- 235000013927 calcium gluconate Nutrition 0.000 description 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 210000001255 hallux Anatomy 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000008035 nerve activity Effects 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for treating cramp and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 10 to 50 parts of wire grasses, 10 to 30 parts of honeysuckles, 10 to 50 parts of lycopodium clavatum and 5 to 30 parts of radix angelicae pubescentis. The traditional Chinese medicine composition is rigorous in formula, has a good treating effect with fewer medicines, has the effects of dispelling wind, eliminating dampness, relaxing tendons and activating collaterals, is good in treating effect on the cramp and takes a quick response.
Description
Technical field
The invention belongs to medicine field, it is related to a kind of treat Chinese medicine composition of cramp and preparation method thereof.
Background technology
Cramp scientific name is muscle cramp, refer to muscle be subject to intense stimulus and find it is a kind of unexpected, involuntary strong
The straight phenomenon shunk, it is typically most commonly seen with the cramp of shank and toe.There is fatigue the reason for causing muscle cramp common, electrolysis
Matter is uneven, cold stimulation, calcium deficiency, hyperpyrexia, epilepsy, lockjaw, rabies etc..It is common disease frequently-occurring disease to knot, though without danger
Danger, but muscle rigidity, hurt like hell can be caused, it is difficult to move, the severe pain brought when especially midnight knots can usually shy people
Wake up, although only continue a few minutes, but after breaking-out, the sense of discomfort of muscle or tenderness can continue several hours, have a strong impact on
Sleep, reduces quality of life.The real mechanism for knotting not yet is known that most research results think, crick is at present
Cause what nerve or Neuromuscular stress threshold value reduction so that muscle nerve action frequency increase suddenly, cause muscle rigidity to receive
Contracting.For knotting, most direct alleviation method is the position that massage occurs spasm, and typically giving medicine stops frightened in treatment, then
The anti-inflammatory of external application, analgesic medicine is equipped with to wipe in affected part.The traditional Chinese medical science think knot more by vim and vigour deficiency, rheumatism, catch a cold, damp and hot institute
Cause, in treatment based on clearing heat and expelling damp, nourshing blood and promoting blood circulation, stimulating the circulation of the blood and cause the muscles and joints to relax.The present invention works out one kind for the pathogenic factor for knotting
The Chinese medicine composition for knotting is treated, at present, there is not yet relevant report.
(1) bermudagrass herb, is that the drying of adiantaceae plant flabellum venushair fern Adiantum flabellulatum L. is complete
Grass.Record in《Guangxi Chinese medicine standard》Nineteen ninety version：【Nature and flavor】It is slight bitter, pungent, it is cool.【Function with cure mainly】It is clearing heat and detoxicating, dampness removing,
Detumescence.For stone in urinary system, hepatitis, dysentery, cold, fever, diarrhea, sand drenches.
(2) honeysuckle, is that the dry flower or band of caprifoliaceae plant honeysuckle Lonicera japonica Thunb. are just opened
Flower.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and return through】It is sweet, tremble with fear.Return lung, the heart, stomach.【Function with cure mainly】Heat-clearing
Removing toxic substances, dispelling wind and heat from the body.Sore, larynx numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating are treated for carbuncle swells.
(3) lycopodium calvatum, is that lycopsid lycopod Lycopodium japonicum Thunb. dry herb.Record
In《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and return through】Slight bitter, pungent, temperature.Return liver, spleen, kidney channel.【Function with cure mainly】Wind-dispelling is removed
It is wet, stimulate the circulation of the blood and cause the muscles and joints to relax.For joint pain, joint stuffiness.
(4) levisticum, is samphire Angelica pubescens Angelica pubescens Maxim.f.biserrata
The dry root of Shan et Yuan.Record in Chinese Pharmacopoeia version in 2015：【Nature and flavor and return through】Pungent, hardship, tepor.Return kidney, bladder
Through.【Function with cure mainly】Dispelling wind and eliminating dampness, numbness relieving and pain relieving.For wind-cold-dampness arthralgia, lumbocrural pain, few the moon volt wind headache, chill is held under the arm wet
Headache.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating cramp good effect, instant effect and preparation method thereof.
The Chinese medicine composition that present invention treatment is knotted, with reference to medication experience among the people, is transported on the basis of traditional Chinese medical science traditional theory
It is formulated with modern scientific theory.Rigorous with prescription, the few power of medicine specially, has good curative effect to cramp, can effectively reduce trouble
The pain of person, improves its symptom, improves the quality of life of patient.
The technical solution adopted in the present invention is as follows：
A kind of Chinese medicine composition for treating cramp, is made up of the traditional Chinese medicinal components of following weight portion：Bermudagrass herb 10-50 parts, gold
Honeysuckle flower 10-30 parts, lycopodium calvatum 10-50 parts, levisticum 5-30 parts.
The Chinese medicine composition that above-described treatment is knotted, is preferably made up of the traditional Chinese medicinal components of following weight portion：Bermudagrass herb
20-40 parts, honeysuckle 10-20 parts, lycopodium calvatum 20-40 parts, levisticum 10-20 parts, most preferably preferably by the Chinese medicine group of following weight portion
It is grouped into：30 parts of bermudagrass herb, 15 parts of honeysuckle, 30 parts of lycopodium calvatum, 15 parts of levisticum.
The Chinese medicine composition that the above treatment is knotted, can be prepared into any formulation allowed on medicine, such as：Capsule,
Tablet, granule, capsule or syrup etc., are preferably made capsule.
The Chinese medicine composition that the above treatment is knotted is made the preparation method of capsule, comprises the following steps：
(1) bermudagrass herb, honeysuckle, lycopodium calvatum, levisticum are taken respectively, is cleaned, dry；
(2) weigh by weight：Bermudagrass herb 10-50 parts, honeysuckle 10-30 parts, lycopodium calvatum 10-50 parts, levisticum 5-30 parts；
(3) add 6-10 times to measure water in load weighted Chinese medicine, heating and refluxing extraction 2-3 times is each 1-3 hours, filter, merge
Filtrate；
(4) gained filtrate be concentrated into relative density be at 60 DEG C 1.25~1.28 thick paste, dry, pulverize, so
Filler and lubricant are added afterwards, is mixed, load capsule, obtain final product.
Wherein described filler be it is well known to those of ordinary skill in the art, such as：Starch, microcrystalline cellulose, lactose, paste
One or more combinations in essence, pregelatinized starch etc., the lubricant is magnesium stearate, talcum powder, silica etc.
In one or more combination.
The Chinese medicine composition that the above treatment is knotted, the application in treatment cramp medicine is prepared.
The Chinese medicine composition that present invention treatment is knotted is on the basis of traditional Chinese medicine traditional theory, with reference to medication among the people warp
Test, be formulated with modern scientific theory.Bermudagrass herb in side, clearing heat and detoxicating, dampness removing is monarch drug in a prescription.Honeysuckle is clearing heat and detoxicating, dredges
Dissipate wind-heat, is ministerial drug.Lycopodium calvatum dispelling wind and eliminating dampness, stimulates the circulation of the blood and cause the muscles and joints to relax, and is adjutant.Levisticum, dispelling wind and eliminating dampness, numbness relieving and pain relieving, to make medicine.It is all
Medicine shares the work(played dispelling wind and eliminating dampness altogether, stimulate the circulation of the blood and cause the muscles and joints to relax.Prescription of the present invention is rigorous, and the few power of medicine specially, to treatment cramp good effect, takes effect
Hurry up.
The beneficial effects of the invention are as follows：
1. bulk drug is taken from herbal species, and flavour of a drug are simple and easy to get, safe without toxic side effect.
2. prescription is rigorous, and the few power of medicine specially, with dispelling wind and eliminating dampness, the effects such as stimulating the circulation of the blood and cause the muscles and joints to relax, can be effectively improved the clinic of patient
Symptom, discomfort and pain that reduction of patient is brought by cramp, improves its quality of life, and treatment is knotted good curative effect,
Total effective rate is up to more than 80%.
Specific embodiment
With reference to specific embodiment, the invention will be further described, but do not limit the scope of the invention and apply
Scope：
First, the preparation of the Chinese medicinal composition capsules agent that treatment is knotted
Embodiment 1
A kind of method that Chinese medicine composition for treating cramp is prepared into capsule, comprises the following steps：
(1) bermudagrass herb, honeysuckle, lycopodium calvatum, levisticum are taken respectively, is cleaned, dry；
(2) weigh by weight：Bermudagrass herb 30kg, honeysuckle 15kg, lycopodium calvatum 30kg, levisticum 15kg；
(3) load weighted Chinese medicine is added into 8 times of amount water, heating and refluxing extraction 2 times, 2 hours every time, filtration, merging filtrate；
(4) gained filtrate is concentrated into the thick paste of relative density 1.26 (60 DEG C), be dry, pulverize, be subsequently adding starch and
Magnesium stearate, mixes, and loads capsule, obtains final product.
Embodiment 2
A kind of method that Chinese medicine composition for treating cramp is prepared into capsule, comprises the following steps：
(1) bermudagrass herb, honeysuckle, lycopodium calvatum, levisticum are taken respectively, is cleaned, dry；
(2) weigh by weight：Bermudagrass herb 10kg, honeysuckle 10kg, lycopodium calvatum 10kg, levisticum 5kg；
(3) load weighted Chinese medicine is added into 6 times of amount water, heating and refluxing extraction 2 times, 3 hours every time, filtration, merging filtrate；
(4) gained filtrate is concentrated into the thick paste of relative density 1.25 (60 DEG C), is dry, pulverize, be subsequently adding crystallite fine
Dimension element, lactose and talcum powder, mix, and load capsule, obtain final product.
Embodiment 3
A kind of method that Chinese medicine composition for treating cramp is prepared into capsule, comprises the following steps：
(1) bermudagrass herb, honeysuckle, lycopodium calvatum, levisticum are taken respectively, is cleaned, dry；
(2) weigh by weight：Bermudagrass herb 40kg, honeysuckle 20kg, lycopodium calvatum 40kg, levisticum 20kg；
(3) load weighted Chinese medicine is added into 9 times of amount water, heating and refluxing extraction 2 times, 2 hours every time, filtration, merging filtrate；
(4) gained filtrate is concentrated into the thick paste of relative density 1.27 (60 DEG C), is dry, pulverize, be subsequently adding crystallite fine
Dimension element and silica, magnesium stearate, mix, and load capsule, obtain final product.
Embodiment 4
A kind of method that Chinese medicine composition for treating cramp is prepared into capsule, comprises the following steps：
(1) bermudagrass herb, honeysuckle, lycopodium calvatum, levisticum are taken respectively, is cleaned, dry；
(2) weigh by weight：Bermudagrass herb 20kg, honeysuckle 10kg, lycopodium calvatum 20kg, levisticum 10kg；
(3) load weighted Chinese medicine is added into 7 times of amount water, heating and refluxing extraction 2 times, 2 hours every time, filtration, merging filtrate；
(4) gained filtrate is concentrated into the thick paste of relative density 1.26 (60 DEG C), be dry, pulverize, be subsequently adding dextrin and
Talcum powder, silica, mix, and load capsule, obtain final product.
Embodiment 5
A kind of method that Chinese medicine composition for treating cramp is prepared into capsule, comprises the following steps：
(1) bermudagrass herb, honeysuckle, lycopodium calvatum, levisticum are taken respectively, is cleaned, dry；
(2) weigh by weight：Bermudagrass herb 50kg, honeysuckle 30kg, lycopodium calvatum 50kg, levisticum 30kg；
(3) load weighted Chinese medicine is added into 10 times of amount water, heating and refluxing extraction 3 times, 1 hour every time, filtration, merging filtrate；
(4) gained filtrate is concentrated into the thick paste of relative density 1.28 (60 DEG C), is dry, pulverize, be subsequently adding lactose, pre-
Gelling starch and silica, mix, and load capsule, obtain final product.
2nd, clinical practice
The Chinese medicine composition that present invention treatment is knotted, once for treating and observing 78 patients, while with commercially available certain company
The calcium gluconate tablet and vitamin D soft capsule (the two takes together) of production are compareed.By the above-mentioned 5 kinds of embodiments for preparing
Sample and control sample, are respectively used to trick cramp, whole body cramp or Jinsuo patient (man 42, female 36, average age 46
Year).The results detailed in Table 1.
The clinical application effect table of table 1
Result shows：Using Chinese medicine composition of the present invention, the treatment total effective rate to knotting reaches more than 80%, high
In control group, illustrate that Chinese medicine composition of the present invention has good curative effect to cramp, can effective reduction of patient pain and discomfort, carry
The quality of life of patient high.It is below several model cases：
Case 1：Perhaps ××, male, 51 years old, and shank often knots at night, and calf muscle rigidity during breaking-out, leg can not be stretched
Directly, big toe also takes out contraction, hurt like hell, disease time 3 months or so to sole center.The embodiment of the present invention 2 is taken, 3 every time, daily
3 times, after continuously taking 3 days, improving situation, cramp number of times is significantly reduced, and pain mitigates during breaking-out, then takes 5 days, and symptom disappears
Lose, recovery from illness is not recurred in 1 year.
Case 2：King's ××, female, 43 years old, the both hands centre of the palm, the double-legged centre of the palm and shank had intermittent cramp, finger during breaking-out,
Toe is not active, and calf has gathered a bag, and leg can not be stretched, hurt like hell, disease time 4 months or so.Take implementation of the present invention
Example 1,3 every time, three times a day, after continuously taking 5 days, improving situation, cramp number of times is significantly reduced, and pain and discomfort mitigate, then
Take 5 days, symptom disappears, recovery from illness is not recurred in 1 year.
Case 3：Hu ××, man, 53 years old, nape was bitterly, it is impossible to bend over, it is impossible to squat down, and turned round dumb, it is impossible to lift leg, hand
Can not stretch in the wrong, large profound step, disease time 6 months or so are unable on foot.The embodiment of the present invention 5 is taken, 3 every time, three times a day,
After continuously taking 10 days, situation takes a favorable turn, and pain mitigates, and can bend over, and can squat down, and hand can stretch in the wrong, can lift leg, can stride
Road, then take 20 days, symptom disappears, recovery from illness, is not recurred in 1 year.
Claims (10)
1. a kind of Chinese medicine composition for treating cramp, it is characterised in that be made up of the Chinese medicine of following weight portion：Bermudagrass herb 10-50
Part, honeysuckle 10-30 parts, lycopodium calvatum 10-50 parts, levisticum 5-30 parts.
2. the Chinese medicine composition of cramp is treated according to claim 1, it is characterised in that by the Chinese medicine group of following weight portion
Into：Bermudagrass herb 20-40 parts, honeysuckle 10-20 parts, lycopodium calvatum 20-40 parts, levisticum 10-20 parts.
3. the Chinese medicine composition of cramp is treated according to claim 1, it is characterised in that by the Chinese medicine group of following weight portion
Into：30 parts of bermudagrass herb, 15 parts of honeysuckle, 30 parts of lycopodium calvatum, 15 parts of levisticum.
4. the Chinese medicine composition for being knotted according to any treatment in claim 1-3, it is characterised in that the Chinese medicine composition
It is made pharmaceutically acceptable any formulation.
5. the Chinese medicine composition for being knotted according to any treatment in claim 1-3, it is characterised in that the Chinese medicine composition
It is made capsule, tablet, granule, capsule or syrup.
6. the Chinese medicine composition for being knotted according to any treatment in claim 1-3, it is characterised in that the Chinese medicine composition
It is made capsule.
7. the Chinese medicine composition that a kind for the treatment of as claimed in claim 1 is knotted is made the preparation method of capsule, it is characterised in that
Comprise the following steps：
(1) bermudagrass herb, honeysuckle, lycopodium calvatum, levisticum are taken respectively, is cleaned, dry；
(2) weigh by weight：Bermudagrass herb 10-50 parts, honeysuckle 10-30 parts, lycopodium calvatum 10-50 parts, levisticum 5-30 parts；
(3) add 6-10 times to measure water in load weighted Chinese medicine, heating and refluxing extraction 2-3 times is each 1-3 hours, filter, merge filter
Liquid；
(4) gained filtrate be concentrated into relative density be at 60 DEG C 1.25~1.28 thick paste, dry, pulverize, Ran Houjia
Enter filler and lubricant, mix, load capsule, obtain final product.
8. the Chinese medicine composition for treating cramp according to claim 7 is made the preparation method of capsule, it is characterised in that institute
It is one or more combinations in starch, microcrystalline cellulose, lactose, dextrin, pregelatinized starch to state filler.
9. the Chinese medicine composition for treating cramp according to claim 7 is made the preparation method of capsule, it is characterised in that institute
It is one or more combinations in magnesium stearate, talcum powder, silica to state lubricant.
10. the Chinese medicine composition for being knotted according to any treatment in claim 1-3, it is characterised in that the Chinese traditional medicine composition
Purposes of the thing in the medicine that treatment is knotted is prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611249794.0A CN106692752A (en) | 2016-12-29 | 2016-12-29 | Traditional Chinese medicine composition for treating cramp |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611249794.0A CN106692752A (en) | 2016-12-29 | 2016-12-29 | Traditional Chinese medicine composition for treating cramp |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106692752A true CN106692752A (en) | 2017-05-24 |
Family
ID=58904074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611249794.0A Pending CN106692752A (en) | 2016-12-29 | 2016-12-29 | Traditional Chinese medicine composition for treating cramp |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106692752A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145057A (en) * | 2010-02-10 | 2011-08-10 | 广州诺迪医药科技有限公司 | Antispasmodic traditional Chinese medicine composition and preparation method thereof |
| CN103169790A (en) * | 2013-02-26 | 2013-06-26 | 孙胜波 | Traditional Chinese medicine composition for treating muscle spasm |
| CN103638431A (en) * | 2013-11-26 | 2014-03-19 | 宋爱民 | Traditional Chinese medicine preparation for treating muscle cramps |
-
2016
- 2016-12-29 CN CN201611249794.0A patent/CN106692752A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145057A (en) * | 2010-02-10 | 2011-08-10 | 广州诺迪医药科技有限公司 | Antispasmodic traditional Chinese medicine composition and preparation method thereof |
| CN103169790A (en) * | 2013-02-26 | 2013-06-26 | 孙胜波 | Traditional Chinese medicine composition for treating muscle spasm |
| CN103638431A (en) * | 2013-11-26 | 2014-03-19 | 宋爱民 | Traditional Chinese medicine preparation for treating muscle cramps |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103656238B (en) | A kind of Chinese medicine composition for the treatment of rheumatic osteopathia | |
| CN102631593B (en) | Preparation method of traditional Chinese medicine lotion for treating oedema lymphangitis | |
| CN105920570A (en) | Quick-acting externally applied traditional Chinese medicine for treating rheumatoid bone diseases and preparation method | |
| CN101450197A (en) | Traditional Chinese medicine for treating rheumatism, rheumatoid disease | |
| CN104758743A (en) | Traditional Chinese medicine foot fumigating powder for treating rheumatism as well as preparation method and using method thereof | |
| CN107582989A (en) | A kind of tying-in strong bone, the Chinese medicine composition and preparation method thereof of relaxing tendons and activating collaterals | |
| CN103735762A (en) | Medicine for treating scapulohumeral periarthritis and preparation method of medicament | |
| CN103432426B (en) | Traditional Chinese medicinal tablets for treating neuralgic amyotrophy and preparation method thereof | |
| CN104257917B (en) | A kind of precious jade medicine external preparation for preventing and treating woman puerperal fever and preparation method thereof | |
| CN102784335A (en) | Traditional Chinese medicine compound lotion for treating urticaria papulosa and preparation method thereof | |
| CN106692752A (en) | Traditional Chinese medicine composition for treating cramp | |
| CN104524397A (en) | Traditional Chinese medicine composition for assisted rehabilitation of stroke and preparation method of composition | |
| CN104027451B (en) | A kind of Chinese medicine for the treatment of deficiency of the liver and kindey pattern of syndrome sciatica | |
| CN103330925A (en) | Drug for treating chorea minor and preparation method thereof | |
| CN106729256A (en) | It is a kind of to treat lavipeditum powder of arthralgia pain due to rheumatism and preparation method thereof | |
| CN106668251A (en) | Medicine for treating rheumatoid arthritis, and preparation method of medicine | |
| CN106620013A (en) | Foot bath powder for treating rheumatoid arthritis, and preparation method of foot bath powder | |
| CN106581514A (en) | Traditional Chinese medicine for treating rheumatic arthralgia | |
| CN106344793A (en) | Traditional Chinese medicine foot bath powder for treating arthritis and preparation method thereof | |
| CN106728098A (en) | A kind of Chinese medicine composition of anti-muscle cramp and preparation method thereof | |
| CN106310172A (en) | Ointment medicine for treating painful diseases and preparing method and use thereof | |
| CN106491734A (en) | A kind of Chinese medicine composition containing Herba cynodontiss and preparation method thereof | |
| CN104922595A (en) | Traditional Chinese medicinal preparation for herpes zoster and preparation method thereof | |
| CN103463428B (en) | Traditional Chinese medicine for treating blood stasis retardant type sciatica | |
| CN104173777A (en) | Traditional Chinese medicine for treating hemiplegia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170524 |