CN106692379A - Pharmaceutical composition for preventing and treating glaucoma and preparation method thereof - Google Patents

Pharmaceutical composition for preventing and treating glaucoma and preparation method thereof Download PDF

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CN106692379A
CN106692379A CN201611133181.0A CN201611133181A CN106692379A CN 106692379 A CN106692379 A CN 106692379A CN 201611133181 A CN201611133181 A CN 201611133181A CN 106692379 A CN106692379 A CN 106692379A
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ethanol
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pharmaceutical composition
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preventing
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61K2236/50—Methods involving additional extraction steps
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating glaucoma and a preparation method thereof. The pharmaceutical composition disclosed by the invention is prepared by taking common anotis herb, plagiogyria distinctissima, heterostemma oblongifolium, dwarf sheareria herb and stenosolenium saxatile as raw medicinal materials according to a ratio. The pharmaceutical composition can be prepared into various dosage forms according to the conventional preparation process and has an obvious curative effect of preventing and treating glaucoma.

Description

Prevent and treat pharmaceutical composition of glaucoma and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for preventing and treating glaucoma and its preparation side Method.
Background technology
The Hemodynamics research of diabetic has shown the dysfunction of the retina blood capillary of diabetic, Hardening and obturation are the basic reasons for causing retinal blood dyshaemia.The view of diabetes non-proliferative phase patient with retinopathy The VPV of film central artery is lower than normal person, and drag index increases with PI, vascular resistance index reflection blood vessel Hemodynamic characteristics, index is high to show that distal vessels bed resistance is big, and CBF is few, and diabetic's blood is in high glutinous State.Increase or during HT state when certain factor promotes retina oxygen demand, can induce or to aggravate diabetic eye micro- Circulate generation, the development of lesion.
Recent studies indicate that glaucoma morbidity in addition to anatomical factors, also physiologic factor the reason for.Wherein choroid Innermost layer be capillary layer, be characterized in that caliber is especially big, be 4 times of normal terminal vessels, and blood capillary herein The pressure of pipe is higher.It is estimated that intraocular blood has 70% to be stored in CC.Capillary is in fenestra Type, basement membrane is thin, therefore it has stronger permeability, as the choroid of one of the maximum organ of unit CBF in body, Its blood flow lacks capacity of self-regulation.
Diabetic is receiving anti-glaucoma surgery, the aggravation of eye Micro-circutation syndrome.For a long time, made with glucocorticoid It is main treatment method, the approach of arachidonic acid generation can be blocked because of it, generates prostaglandin few, vascular permeability Property decline, and lower because of the increased vascular endothelial growth factor of its vasopermeability, mitigate the broken of blood retina barrier It is bad.But diabetic makes oculist in a dilemma using the blood glucose rise phenomenon after hormone therapy.The diabetes spp traditional Chinese medical science " quenching one's thirst " category is learned, its interpretation of the cause, onset and process of an illness is " deficiency of Yin is this, and scorching is mark ", dry to hinder body fluid, kidney deficiency and liver, deficiency of both qi and yin, the deficiency of vital energy The blood stasis of blood is stagnant." glaucoma " traditional Chinese medical science is referred to as " bluish glaucoma ", belongs to caused by liver and kidney deficiency, liver-yang hyperactivity, the bright body fluid of heat, poly- liquid into Phlegm, stasis blocking train of thought is qi-blood disharmony.Traditional Chinese medical science surgery trauma is called " incised wound ", causes local zang-fu differentiation qi and blood unbalance, is made Damaged into train of thought, so as to further aggravate qi and blood stagnation.
Common anotis herb：It is Rubiaceae vacation plants of Hedyotis common anotis herb Anotis ingrata (wall.) Hook. F. The herb of [Neanotis yngrata (Wall.ex Hook .f) W.H.Lewis].Summer, autumn receive adopt herb, eliminate soil, Debris, dry standby.【Nature and flavor】Taste is pungent；It is cool in nature.【Return through】The heart；Liver Channel.【Indication】Clearing liver-fire.Main nameless sores or boils；Mesh It is crimson swollen；Venomous snake bite.【Former phytomorph】Renascent herb, up to 1m.Stem branch or does not have a small number of branches, upright or bottom Sleeping ground.Leaf opposite；Petiole is short；The nearly triangle in stipule bottom, joint is born between two petioles, edge tool fine hair；Blade is thin Papery, oval or oval long are to ovum shape lanceolar, and 4-9cm long, about 1.8cm wide, tip is tapering, base portion wedge shape, full edge, two Face is by pubescence.Dichasium basidixed, total bennet and branch have narrow aliform corner angle；Floral white, without obstructing or have short stalk； Calyx 4 splits, sliver triangular shape lanceolar, and corolla is about 5mm, and hat manages slightly wider, interior raw pubescence；Stamen 4, flower pesticide exposes outside corolla； Ovary is the next, and Room 2, column cap 2 splits.Capsule is subsphaeroidal, slightly flat-sided, about 2mm wide.Seed is small and most, plano-convex, there is small wart point.Flower Month phase 6-7, the fruiting period 7-8 months.Record in dictionary of medicinal plant.
Plagiogyria distinctissima ching：It is Plagiogyriaceae knurl foot Cyclosorus plant Plagiogyria distinctissima ching Plagiogyria rankanensis Hayata[P.distinctissima Ching;P.adnata Bedd.] herb or rhizome.Summer, autumn harvesting, clean, and shine It is dry.【Nature and flavor】It is pungent；It is cool.【Return through】Enter bladder, lung, the warp of liver three.【Indication】Deliver heat-clearing；Dispelling wind and arresting itching；Promoting eruption.Main flow row Sexuality emits；Measles；Pruitus；Metrorrhagia；Sprain.【Former phytomorph】Plant 30-45cm high.Has the rhizome of upright or oblique ascension. Leafage gives birth to, two types；Nutrition petiole 14-18cm long, base portion prismatic has 1-2 to pneumatophore, is slightly in upwards prismatic or semicircle Shape；Blade long-narrow triangular mesh or ovum shape lanceolar, 17-25cm long, base portion 8-11cm wide, a pinnation；Accessory pinna papery, 15-20 pairs, alternate, 4-6cm long, 8-13mm wide, top and bottom are green, and acumen is micro-bend in falciform lanceolar, base portion upwards Asymmetric, upside is prolonged along rachis, and downside is circular, edge nearly full edge or with teeth；Vein pinniform, lateral vein is single or two forked.Spore Cotyledon petioles 30-40cm long；Time pinniform of blade, 14-22cm long, 4-6cm wide；Accessory pinna 15-25 pairs, it is in linear extremely to shrink, 5-7cm long, 2-3mm wide；The usual y-bend of lateral vein, extends at limb 1/2.Sporangium is born in scun top, and accessory pinna is covered with when ripe Below.Record in dictionary of medicinal plant.
Purple cylinder grass：This product is Boraginaceae purple cylinder grass platymiscium purple cylinder grass Stenosolenium saxatile（Pall.） Turcz.[Anchusa saxatile Pall. ;Onosma saxatile (Pall.) Lehm.] herb and root.【Property Taste】It is bitter, pungent, it is cool.【Indication】Clearing heat and cooling blood, cough-relieving of stopping blooding.Cure mainly haematemesis, cough with lung heat.Flu, arthralgia.【Original is planted Thing form】Purple cylinder grass is long 8-25 centimetres, close by thick and stiff hair and pubescence.Root appearance atropurpureus is dark brown, the black purple of section skin zone Color, woody part yellowish white, diameter 0.5-2 millimeters.Stem is in celadon or crineous, and section off-white color is hollow, diameter 0.5-2.5 Millimeter;Leaf alternate, crushes more or crimps, herbaceous stem, celadon, and complete person is in drape over one's shoulders pin bar shaped, drape over one's shoulders needle-like bar shaped.Flower brown color. Pyrene is avette in triangular shape, normal 4 it is raw together.Gas is micro-, mildly bitter flavor.Record in dictionary of medicinal plant.
Iris-leaf oberonia herb：This product is orchid family iris epidendrum iris orchid Oberonia iridifolia (Roxb.) Lindl. The herb of [Cymbidium iridifolium Roxb.].Whole year can be harvested, and boiling water is dried after scalding.【Nature and flavor】Slight bitter；Property It is cool.【Return through】Bladder warp.【Indication】Clearing heat and promoting diuresis；It is promoting blood circulation and removing obstruction in channels.Main urinary tract infections；Bronchitis；Asthma；Enteritis；Disappear Change bad；Traumatic injury；Fracture.【Former phytomorph】Iris is blue, perennial draft of growing nonparasitically upon another plant, 12-30cm high, fasciation majority palpus Root.Leaf is thick, and both sides are flattened and mutual intussusception, sword-shaped or round shape lanceolar long, and 4-13cm long, 1-2cm wide, tip is sometimes slightly askew Tiltedly, base portion has joint.Raceme is extracted out from plant center, is longer than leaf, uprightly, cylinder, the most intensive little Hua of tool；It is small The thin keratin of bract, avette, 1.5-2mm long.Spend small, diameter about 2mm, white green；Sepal and the equal reflexed of petal, petal compare sepal It is narrow；Lip is closely semicircle, and shape is closely eroded at edge, and tip 2 splits.Capsule obovate elliptic, is about 5mm, handle 1.5mm long.Florescence The 10-11 months, the fruiting period 11-12 months.Record in dictionary of medicinal plant.
Dwarf sheareria herb：This product is the herb of composite family dwarf sheareria herb platymiscium dwarf sheareria herb Sheareria nana S. Moore.Summer, Autumn is harvested, and magnesium is used or dried.【Nature and flavor】Bitter；It is mild-natured.【Indication】It is clearing heat and detoxicating；Inducing diuresis for removing edema.Main sore swollen toxin；Water It is swollen；Headache due to pathogenic wind-heat.【Former phytomorph】Annual herb.Stem is upright, high 30~40 centimetres, the following branch in middle part.Leaf alternate, it is dilute Dredge, linear, long 1~3 centimetre, wide 2~3 millimeters, tip point, base portion is narrow, full edge, stockless.Capitulum is small, basidixed；Spend minority； Involucre is bell, 2 layers of bract, and outer layer bract is extensively avette, and internal layer bract is slightly larger；Ligulate flower 3~4, white, female；Tubular flower 2~ 3, both sexes.Achene oblong.8~September of florescence.Record in dictionary of medicinal plant.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided it is a kind of effectively prevent and treat glaucoma pharmaceutical composition and Its preparation method.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition for preventing and treating glaucoma be：
Common anotis herb 220-226 weight portion Plagiogyria distinctissima ching 230-238 weight portion Oblongleaf Heterostemma 210-214 weight portion dwarf sheareria herbs 130- 134 weight portions purple cylinder grass 110-112 weight portions.
The pharmaceutical composition for preventing and treating glaucoma is preferably used in, is made up of the bulk drug of following weight portion：
The weight portion of 212 weight portion dwarf sheareria herb of common anotis herb 223 weight portion Plagiogyria distinctissima ching, 234 weight portion Oblongleaf Heterostemma 132 purple cylinder grass 111 weight portions.
A kind of pharmaceutical composition for preventing and treating glaucoma, it is characterised in that pharmaceutical composition can be using the routine side of galenic pharmacy Method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for preventing and treating glaucoma, it is characterised in that pharmaceutical composition is anti-with what chemical drugs or Chinese medicine were constituted Control glaucoma medicine.
A kind of preparation method of the pharmaceutical composition for preventing and treating glaucoma, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Common anotis herb 220-226 weight portion Plagiogyria distinctissima ching 230-238 weight portion Oblongleaf Heterostemmas 210-214 weight portion dwarf sheareria herb 130-134 weight portions purple cylinder grass 110-112 weight portions；
Preparation method：
（1）Common anotis herb, Plagiogyria distinctissima ching, Oblongleaf Heterostemma, dwarf sheareria herb, purple cylinder grass are taken by bulk drug proportioning, is mixed, use percentage by weight The ethanol of concentration 46% takes as solvent in 23 DEG C of temperature extractions, and extraction time is 19 times, and each extraction time is 15 hours, molten every time Agent consumption is 68 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close Degree 1.08, filtration, liquid is first washed with water by HP40 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 32% Liquid wash-out HP40 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 32%, recovery ethanol, concentrate drying, i.e., Obtain extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 7 times is carried every time The time is taken for 1.1 hours, each solvent load is 40 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns The ethanol solution of weight percent concentration 86% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 86% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for preventing and treating glaucoma, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：The weight of 223 weight portion Plagiogyria distinctissima ching of common anotis herb, 234 weight portion Oblongleaf Heterostemma 212 Part dwarf sheareria herb 132 weight portion purple cylinder 111 weight portions of grass；
Preparation method：
（1）Common anotis herb, Plagiogyria distinctissima ching, Oblongleaf Heterostemma, dwarf sheareria herb, purple cylinder grass are taken by bulk drug proportioning, is mixed, use percentage by weight The ethanol of concentration 46% takes as solvent in 23 DEG C of temperature extractions, and extraction time is 19 times, and each extraction time is 15 hours, molten every time Agent consumption is 68 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close Degree 1.08, filtration, liquid is first washed with water by HP40 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 32% Liquid wash-out HP40 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 32%, recovery ethanol, concentrate drying, i.e., Obtain extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 7 times is carried every time The time is taken for 1.1 hours, each solvent load is 40 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns The ethanol solution of weight percent concentration 86% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 86% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for preventing and treating glaucoma, it is characterised in that pharmaceutical composition can use preparation Conventional method prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for preventing and treating glaucoma, it is characterised in that pharmaceutical composition and chemical drugs or in Medicine composition preventing and treating glaucoma medicine.
It is evident in efficacy that pharmaceutical composition prevents and treats glaucoma.
Specific embodiment
Embodiment 1：Prevent and treat pharmaceutical composition of glaucoma and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of glaucoma be：Common anotis herb 223g Plagiogyria distinctissima chings 234g Oblongleaf Heterostemma 212g dwarf sheareria herbs 132g purple cylinder grass 111g；
Preparation method：
（1）Common anotis herb, Plagiogyria distinctissima ching, Oblongleaf Heterostemma, dwarf sheareria herb, purple cylinder grass are taken by bulk drug proportioning, is mixed, use percentage by weight The ethanol of concentration 46% takes as solvent in 23 DEG C of temperature extractions, and extraction time is 19 times, and each extraction time is 15 hours, molten every time Agent consumption is 68 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close Degree 1.08, filtration, liquid is first washed with water by HP40 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 32% Liquid wash-out HP40 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 32%, recovery ethanol, concentrate drying, i.e., Obtain extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 7 times is carried every time The time is taken for 1.1 hours, each solvent load is 40 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns The ethanol solution of weight percent concentration 86% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 86% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Prevent and treat pharmaceutical composition of glaucoma and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of glaucoma be：Common anotis herb 220g Plagiogyria distinctissima chings 238g Oblongleaf Heterostemma 210g dwarf sheareria herbs 134g purple cylinder grass 110g；
Preparation method：
（1）Common anotis herb, Plagiogyria distinctissima ching, Oblongleaf Heterostemma, dwarf sheareria herb, purple cylinder grass are taken by bulk drug proportioning, is mixed, use percentage by weight The ethanol of concentration 46% takes as solvent in 23 DEG C of temperature extractions, and extraction time is 19 times, and each extraction time is 15 hours, molten every time Agent consumption is 68 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close Degree 1.08, filtration, liquid is first washed with water by HP40 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 32% Liquid wash-out HP40 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 32%, recovery ethanol, concentrate drying, i.e., Obtain extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 7 times is carried every time The time is taken for 1.1 hours, each solvent load is 40 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns The ethanol solution of weight percent concentration 86% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 86% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Prevent and treat pharmaceutical composition of glaucoma and preparation method thereof
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of glaucoma be：Common anotis herb 226g Plagiogyria distinctissima chings 230g Oblongleaf Heterostemma 214g dwarf sheareria herbs 130g purple cylinder grass 112g；
Preparation method：
（1）Common anotis herb, Plagiogyria distinctissima ching, Oblongleaf Heterostemma, dwarf sheareria herb, purple cylinder grass are taken by bulk drug proportioning, is mixed, use percentage by weight The ethanol of concentration 46% takes as solvent in 23 DEG C of temperature extractions, and extraction time is 19 times, and each extraction time is 15 hours, molten every time Agent consumption is 68 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close Degree 1.08, filtration, liquid is first washed with water by HP40 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 32% Liquid wash-out HP40 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 32%, recovery ethanol, concentrate drying, i.e., Obtain extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 7 times is carried every time The time is taken for 1.1 hours, each solvent load is 40 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns The ethanol solution of weight percent concentration 86% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 86% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 56g of Example 1, adds starch 85g, mixes, and granulation is dried, plus microcrystalline cellulose 32g, stearic acid Magnesium 1g, mixes, and is pressed into 550, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 170g of Example 2, adds starch 220g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid Magnesium, mixes, and encapsulated 1000, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 183g water-baths and boil molten, add the pharmaceutical composition 14g of embodiment 3, fully stir Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is 6 DEG C, and drip internal-and external diameter is 7.0/ 2.0 (mm/mm), drip is 2.1cm away from liquid level, and drop speed is optimum condition with every point 57 drop, and the cold of dripping pill surface is blotted with cotton Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：Prevent and treat the pharmaceutical composition of glaucoma
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of glaucoma be：
The weight portion of 100 weight portion dwarf sheareria herb of Oblongleaf Heterostemma, 280 weight portion Plagiogyria distinctissima ching 190.
Embodiment 8：Prevent and treat the pharmaceutical composition of glaucoma
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of glaucoma be：
The weight portion of 120 weight portion dwarf sheareria herb of Oblongleaf Heterostemma 250 purple cylinder 160 weight portions of grass.
Embodiment 9：Prevent and treat the pharmaceutical composition of glaucoma
The composition and weight portion for preventing and treating the bulk drug of the pharmaceutical composition of glaucoma be：
The weight portion of 150 weight portion dwarf sheareria herb of Oblongleaf Heterostemma 240 purple cylinder 170 weight portions of grass.
Experimental example 1：Prevent and treat the experimental study of glaucoma
1 data and method
1.1 data
Diabetes mellitus glaucoma patient 38 (56) be this city hospital in March, 2012 to 2 months 2013 be in hospital implement glaucoma The postoperative patient of Trabecula resection, wherein Chinese medicine group 19 (28), the people of male 10, the people of women 9；Average age 60.4 years old；II type The people of diabetes 15, the people of IDDM 4；The people of open-angle glaucoma 4, the people of angle-closure glaucoma 15.Western medicine group 19 (28), its The people of middle male 10, the people of women 9；Average age 60.8 years old；The people of type II diabetes 15, the people of IDDM 4；Open-angle glaucoma 4 People, the people of angle-closure glaucoma 14, the people of other types glaucoma 1.All diabetics make a definite diagnosis through division of endocrinology of our hospital, diabetes Medical history is different in size, preoperative fasting blood-glucose≤8.0mmol/L, preoperative intraocular pressure≤35mmHg.It is statistically analyzed, two groups of trouble Person's there are no significant in sex, age, the course of disease, state of an illness difference, with comparativity.
1.2 diagnostic criteria
Diabetic makes a definite diagnosis according to the standard that WHO is announced.Glaucoma patient meets ophthalmology, hals,Nasen und Ohrenheilkunde conventional treatment and examines Disconnected standard and the person that meets surgical condition.
1.3 operation methods
All patients suture scleral flap by same position eye doctor routinely row trabeculectomy.
1.4 aftertreatments
1.4.1 Chinese medicine group
Operation completes to give the pharmaceutical composition of soothing the liver enriching yin, nourishing blood for improving eyesight from this very day（The pharmaceutical composition of embodiment 1）, every time 1g, it is oral that 3 times a day, and oral indometacin 25mg, and 3 times a day, is within continuous 14 days 1 course for the treatment of.
1.4.2 Western medicine group
Operation completes to give the physiological saline 250ml+ methylate prednisolone 40mg of drip-feed 0.9%, clothes of being withdrawn the previous remark after 1 week from this very day Prednisone 30mg, one time a day, the mg of tapered dosage 5, totally 1 week.
Two groups of Topical corticosteroid ocular fluid and cycloplegics from postoperative 1st day.
1.5 observation items
The eyesight fluctuation of postoperative patients；Intraocular pressure；The visual field；Optic disk cup disc ratio；The depth of anterior chamber；Inflammatory reaction；Corneal endothelium shape State；Filtration bleb.
2 results
2.1 efficacy assessment standards
Drafted with reference to ophthalmology, hals,Nasen und Ohrenheilkunde conventional treatment.Cure:Intraocular pressure recovers normal range (NR), and the visual field, eyeground infringement are controlled System.Take a turn for the better:Intraocular pressure declines, and the visual field, eyeground are unchanged.Do not heal:Intraocular pressure does not drop, and the visual field continues to zoom out, eyeground infringement aggravation.
2.2 total effectses
Cure 13 in Chinese medicine group, take a turn for the better 13, not more 2, total effective rate is 92.86%.Western medicine group cures 10, improvement 11 Eye, not more 7, total effective rate is 75.0% (P<0.05).
2.3 two groups of clinical symptoms changes (table 1)
Two groups of changes (n) of clinical symptoms after the treatment of table 1
Pharmaceutical composition improves to clinical symptoms and is better than control group.

Claims (8)

1. a kind of pharmaceutical composition for preventing and treating glaucoma, it is characterised in that be made the composition and weight of the bulk drug of the pharmaceutical composition Measuring part is：
Common anotis herb 220-226 weight portion Plagiogyria distinctissima ching 230-238 weight portion Oblongleaf Heterostemma 210-214 weight portion dwarf sheareria herbs 130-134 weight portions purple cylinder grass 110-112 weight portions.
2. a kind of pharmaceutical composition for preventing and treating glaucoma according to claim 1, it is characterised in that be made the pharmaceutical composition Bulk drug composition and weight portion be：
The weight portion of 212 weight portion dwarf sheareria herb of common anotis herb 223 weight portion Plagiogyria distinctissima ching, 234 weight portion Oblongleaf Heterostemma 132 purple cylinder Careless 111 weight portions.
3. a kind of pharmaceutical composition for preventing and treating glaucoma according to claim 1, it is characterised in that pharmaceutical composition can be adopted Piece agent or capsule or dripping pill are prepared with the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition for preventing and treating glaucoma according to claim 1, it is characterised in that pharmaceutical composition and chemistry The preventing and treating glaucoma medicine of medicine or Chinese medicine composition.
5. a kind of preparation method of the pharmaceutical composition for preventing and treating glaucoma, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Common anotis herb 220-226 weight portion Plagiogyria distinctissima ching 230-238 weight portion Oblongleaf Heterostemmas 210-214 weight portion dwarf sheareria herb 130-134 weight portions purple cylinder grass 110-112 weight portions；
Preparation method：
（1）Common anotis herb, Plagiogyria distinctissima ching, Oblongleaf Heterostemma, dwarf sheareria herb, purple cylinder grass are taken by bulk drug proportioning, is mixed, use percentage by weight The ethanol of concentration 46% takes as solvent in 23 DEG C of temperature extractions, and extraction time is 19 times, and each extraction time is 15 hours, molten every time Agent consumption is 68 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close Degree 1.08, filtration, liquid is first washed with water by HP40 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 32% Liquid wash-out HP40 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 32%, recovery ethanol, concentrate drying, i.e., Obtain extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 7 times is carried every time The time is taken for 1.1 hours, each solvent load is 40 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns The ethanol solution of weight percent concentration 86% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 86% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for preventing and treating glaucoma according to claim 5, it is characterised in that by as follows It is prepared by step：
The composition and weight portion of bulk drug be：The weight of 223 weight portion Plagiogyria distinctissima ching of common anotis herb, 234 weight portion Oblongleaf Heterostemma 212 Part dwarf sheareria herb 132 weight portion purple cylinder 111 weight portions of grass；
Preparation method：
（1）Common anotis herb, Plagiogyria distinctissima ching, Oblongleaf Heterostemma, dwarf sheareria herb, purple cylinder grass are taken by bulk drug proportioning, is mixed, use percentage by weight The ethanol of concentration 46% takes as solvent in 23 DEG C of temperature extractions, and extraction time is 19 times, and each extraction time is 15 hours, molten every time Agent consumption is 68 times of bulk drug gross weight, is filtered, and obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relatively close Degree 1.08, filtration, liquid is first washed with water by HP40 large pore resin absorption columns, then molten with the ethanol of weight percent concentration 32% Liquid wash-out HP40 large pore resin absorption columns, the collection ethanol eluate of weight percent concentration 32%, recovery ethanol, concentrate drying, i.e., Obtain extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 53% as solvent, heating and refluxing extraction 7 times is carried every time The time is taken for 1.1 hours, each solvent load is 40 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned Ethanol is received, relative density 1.12 is concentrated into, filtered, liquid is first washed with water, then use by SIP1200 large pore resin absorption columns The ethanol solution of weight percent concentration 86% elutes SIP1200 large pore resin absorption columns, collects the ethanol of weight percent concentration 86% Eluent, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for preventing and treating glaucoma according to claim 5, it is characterised in that medicine group Compound can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition for preventing and treating glaucoma according to claim 5, it is characterised in that medicine group Compound and chemical drugs or Chinese medicine composition preventing and treating glaucoma medicine.
CN201611133181.0A 2016-12-10 2016-12-10 Pharmaceutical composition for preventing and treating glaucoma and preparation method thereof Withdrawn CN106692379A (en)

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