CN106692373A - Traditional Chinese medicine composition for treating endocrine dyscrasia, as well as preparation method and application thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating endocrine dyscrasia. The composition is prepared from the following medicinal materials in parts by weight: 10-30 parts of herba cistanche and 3-10 parts of rosa rugosa, and has a total effective rate of over 93 percent for treating endocrine dyscrasia, wherein the herba cistanche and rosa rugosa are prepared by adopting a combined drying method of nitrogen-source low-oxygen heat pump drying and vacuum drying, so that energy consumption of drying can be reduced, the drying efficiency can be improved, the defects of low drying efficiency and long drying duration in the drying late phase of a heat pump can be avoided, the problem of reduced quality of medicinal materials can be effectively avoided, oxidation loss of effective ingredients and volatilization loss of volatile aromatic ingredients can be reduced, and a dried product with natural color can be obtained. The dried rose flowers have the original fresh color, the nutrition and health effect of rose flowers can be furthest maintained; and the content of echinacoside and verbascoside in cistanche medicinal slices is increased by 2-5 times in comparison with that by an existing process.

Description

A kind of Chinese medicine composition and preparation method and its usage for treating endocrinopathy

Technical field

The invention belongs to Medicines and Health Product field, it is related to a kind for the treatment of endocrinopathy containing saline cistanche and rose Chinese medicine composition and preparation method and its usage.

Background technology

The wide range that endocrinopathy includes, is not a single disease, and it includes sex hormone, adrenal cortex The imbalance of the aspects such as hormone, insulin, thyroxine, exception occurs in all of hormone can be referred to as endocrinopathy.It is modern Medical research confirms that endocrinopathy is internal by the alluvial of body metabolism waste, it is impossible to timely and effectively excludes and is formed, can lead Skin of face decrease of platelet is caused, auburn abnormal pigmentary deposit on the skin trace, such as freckle, chloasma, senile plaque expelling, butterfly macules, melanin deposition is produced Etc. illness, the illnesss such as disease of immune system, osteoporosis, hyperlipemia, climacteric metancholia can be also induced.At present, for Endocrinopathy, doctor trained in Western medicine is adjusted primarily directed to endocrine, allows endocrine to reach balance again.It is excessive for hormone secretion And trigger hyperfunction, treated using the method for Drug inhibition and abatement；And caused imbalance very few for hormone secretion is suffered from Person, takes the hormone of supplement physiological dose.Though the characteristics of western medicine endocrinopathy has instant effect, can not in the presence of taking stopgap measures Effect a permanent cure, and with the deficiency of certain side effect.

The traditional Chinese medical science thinks that endocrinopathy is the performance of kidney deficiency, is caused by qi and blood is retarded by silt.Extravasated blood is detained internal, train of thought It is obstructed, outer malicious human body, lochiostasis etc. of invading may all be led to that qi and blood is retarded by silt.Suitable kidney tonifying is controlled to adjust liver, the promoting flow of qi and blood circulation, dissipate Knot stasis eliminatings.According to theory of traditional Chinese medical science, for the pathogenesis of endocrinopathy, dialectical compatibility group is carried out using saline cistanche and rose Side, to reach the purpose treated both principal and secondary aspect of disease.

The drying of traditional rose uses hot air circulation drying means, the method although practicality simple to operate, but heat The transmission of wind circulated heat is that from outer layer to internal layer, because the petal of rose does not open or parts a little open, petal is from level to level tightly Cladding, the moisture of internal layer petal is difficult to escape, causes when outer layer petal has been completely dried, or even during excessive dehydration, internal layer petal Also it is difficult to dehydrate, in order that internal layer petal can be dehydrated, the temperature of hot air circulation drying means is up to more than 80 DEG C, causes The method that hot air circulation dries rosebud has the following disadvantages：1. the excessive dehydration of outer layer petal is so that outer layer petal is easier to receive Damage, moisture skewness in rose dried flower flower bud, fickle in love is yellow, the attractive in appearance of rose profile is influenceed, due to heating-up temperature Higher, the color and luster of bud is dimmed, in order that bright in colour, a small number of processing stands are smoked using sulphur；2. hot blast temperature is too high, Heat time is long cause outer layer petal in active ingredient be lost in, influence effect of bud；Because heating-up temperature is high, fresh rose flower Fragrance almost all exhaust, dried flower it is soaked after without any rose fragrance audible；3. temperature is high, and the time is long and then energy Consume higher, low production efficiency.

Fresh herba cistanches fleshy stem volume is big, and water content (70%-85%) high, sugar content are (27%-46%) high, processed Cheng Buyi is dried.Traditional diamond-making technique is had been used up being placed in fresh herba cistanches fleshy stem under sunlight and dries, or shady place is dried in the shade, Or dried after salt marsh, or dried after stripping and slicing, section, technique falls behind, drying process slowly, short then two weeks, it is long then one To two months.At present, process is dried in saline cistanche, is influenceed by planting scale and production cost, most of meat desert Rong uses the drying means of natural drying.This method has the advantages that low cost, easy to operation, but natural drying receives ring Condition influence in border is larger, and saline cistanche is susceptible to go mouldy, or even saline cistanche can be made all to rot, and causes the waste of raw material and serious Economic loss.But because saline cistanche picking time is shorter, slice processing occupied ground is big, time-consuming to take a lot of work, individual in drying process Body size, if suppression enzyme, drying mode etc. can influence the active component content and exterior quality of saline cistanche, so as to influence meat desert The medicinal effects of Rong.The habitat processing method of current saline cistanche is mainly the research to saline cistanche fresh slices：(the patents such as Guo Yuhai CN102526212A) report new technology and apply to the drying of saline cistanche piece first and add with Jiang Yong etc. (patent CN104138420A) Work；(patent CN1284556C) such as Tu Pengfei kills enzyme so as to improve echinacoside content using hot-water soak to saline cistanche piece；It is stifled (the patent CN1823914A), Lei Li etc. (patent CN101485731A) and Geng Zongcheng etc. (patent CN104127506A) such as year life are complete Standing time, slice thickness investigated, have killed the influence of enzyme mode and drying mode to benzyl carbinol glycoside content in face.He Wenjun exists CN201210025607.6 provides a kind of saline cistanche freeze-drying fresh-keeping process technique, is dehydrated using freezing vacuum, will Rapid vacuum is dehydrated under cold conditions for saline cistanche section, will not be sent out with the heat-sensitive substance for saline cistanche is contained Changing property or loss are little, and the advantages of can keep original proterties and structure, but time-consuming, and energy consumption is larger with cost, after drying Saline cistanche dissolubility difference etc..

Due to the natural active matter of saline cistanche and rose have thermal sensitivity it is strong, it is oxidizable the features such as, heat drying Quality will directly affect the quality of product, and the quality of product significantly affects the curative effect of clinic.Traditional drying means lacks System, science drying theory and strict production control, its institutional framework are easily destroyed, and the flavour of a drug property of medicine can change, Loss of effective components is serious.Heat pump drying as modern drying means, with energy saving, product quality be high, environmental pollution It is small, the advantages of capacity usage ratio is high, meet the theme of era development, be well suited for the drying of Chinese medicine, and can ensure that good Dry mass.And the advanced technology such as vacuum freeze drying and infrared radiation drying, although active matter in drying process can be reduced The loss of matter, but the price of costliness and relatively low drying capacity constrain their applications in actual production.Heat pump drying skill Art is not yet applied in the process of saline cistanche and rose.

The content of the invention

In order to overcome the shortcomings of that the presence of prior art western medicines in treatment endocrinopathy is cured the symptoms, not the disease and side effect is big, this Invention is provided a kind of prepares simplicity, low cost, the evident in efficacy, Chinese medicine composition for the treatment of endocrinopathy that has no side effect and system Preparation Method and application thereof.

To achieve these goals, the technical solution adopted in the present invention is as follows：

A kind of Chinese medicine composition for treating endocrinopathy, it is characterised in that the Chinese medicine composition is by following parts by weight Medicine preparation is formed：Saline cistanche 10-30 parts, rose 3-10 parts.

Preferably, the medicine preparation of the following parts by weight of the Chinese medicine composition is formed：Saline cistanche 15-25 parts, rose 4-8 Part；More preferably 18 parts of saline cistanche, 6 parts of rose.

Further, the Chinese medicine composition adds acceptable auxiliary material or is not added with auxiliary material and is made clinically acceptable dose Type, the formulation is tea bag, powder, granule, tablet, capsule or oral liquid.

It is a further object of the present invention to provide the preparation method of the Chinese medicine composition of described treatment endocrinopathy, its It is characterised by comprising the following steps：

A) new fresh-rose is prepared into rose medicine materical crude slice through source nitrogen heat pump drying and vacuum drying, it is standby；The rose Rare flower is the dry flower or corolla of rosaceous plant rose Rosa rugosa Thunb.；

B) desertliving cistanche sheet is prepared into through source nitrogen heat pump drying and vacuum drying after fresh herba cistanches are first cut into slices, it is standby With；

C) above-mentioned rose and desertliving cistanche sheet are taken, 20-100 mesh powder is respectively crushed into, it is standby；Rose is weighed by formula Flower and saline cistanche powder, are sufficiently mixed 10~25 minutes with three-dimensional motion mixer, by recipe quantity loaded on brewing in bag, are made bag Make tea；

D) or not carry out pulverization process, take step a) and b) obtained by rose and desertliving cistanche sheet, directly by prescription Amount is made tea bag loaded on brewing in bag.

Preferably, the preparation method of the Chinese medicine composition of described treatment endocrinopathy, it is characterised in that including following Step：By the new fresh-rose and fresh herba cistanches of recipe quantity, impurity is picked, cleaned, drained, after draining, plus 10-15 times is measured 60~80% ethanol solution refluxing extraction 2-3 times, extract 1-2 hour every time, merge extract solution and reclaim ethanol, concentration is dry It is dry, crush and dried cream powder is obtained；Plus appropriate amount of auxiliary materials is made particle with granulator granulation, tea bag, powder, granule, piece are prepared into Agent, capsule.

Further, the preparation method of the Chinese medicine composition of described treatment endocrinopathy, it is characterised in that described Rose medicine materical crude slice step of preparation process it is as follows：

1) the new fresh-rose plucked using stainless steel mesh screening, removes blade and the rose for having opened, standby；

2) heat pump drier hothouse power supply is opened, the assisted heating device started in hothouse is preheated at least to hothouse 30min；Preheating terminates to be passed through nitrogen in backward hothouse, oxygen concentration in hothouse is reduced to 5-10%；Then by above-mentioned step Rapid rose 1) is first uniformly spread on stainless steel mesh；The screen cloth that rose will be filled again is put in source nitrogen heat pump drier In hothouse；

3) 4~8h is dried to rose in heat pump drier hothouse, Drying Technology Parameter is：Done in drying process Dry room temperature be 30~50 DEG C, wind speed of blast blower be 1~2m/s, in drying process in hothouse oxygen purity be 5~ 10%；

4) after heat pump drying terminates, the screen cloth that will fill rose takes out, and is placed in and 2~4h is dried in vacuum drying chamber, does Dry house vacuum degree is 1~3KPa, and drying temperature is 40~60 DEG C；

5) gained rose is uniform after vacuum drying terminates spreads in shady and cool, clean, ventilation tempering；Described tempering side Method is to be spread rose, spreads density for 2-5kg/m², thickness is 2-5cm, spreads the time for 4-8h.

6) rose after tempering is loaded in the compound valve bag of LDPE materials, after nitrogen charging makes bag internal oxygen concentration≤5% Sealing preserve.

Further, the preparation method of the Chinese medicine composition of described treatment endocrinopathy, it is characterised in that described Desertliving cistanche sheet step of preparation process it is as follows：

1) using the fresh herba cistanches of stainless steel mesh screening excavation, cleaning after draining, is cut to 2-4 parts, standby；

2) heat pump drier hothouse power supply is opened, the assisted heating device started in hothouse is preheated at least to hothouse 30min, preheating terminates to be passed through nitrogen in backward hothouse, oxygen concentration in hothouse is reduced to 5-10%；；Then by above-mentioned meat Desert cistanche is first uniformly spread on stainless steel mesh；The screen cloth that saline cistanche will be filled again is put in source nitrogen heat pump drier hothouse It is interior；Saline cistanche in heat pump drier hothouse is dried to dry very likely makes water content up to 20~30%, drying process ginseng Number is：It is 25~45 DEG C that room temperature is dried in drying process, and wind speed of blast blower is 1~3m/s；Oxygen purity in hothouse It is 5~10%；

3) after heat pump drying terminates, the screen cloth that will fill saline cistanche takes out, and cuts 3-5mm sheets, and water steams and kills at enzyme for 10 minutes Reason, is placed in vacuum drying chamber and dries to water content less than 10%, and vacuum is 1~3KPa in hothouse, and drying temperature is 40 ~60 DEG C；

4) by compound valve bag of the dried saline cistanche piece loaded on LDPE materials, nitrogen charging makes bag internal oxygen concentration≤5% Sealing preserve afterwards.

Present invention also offers application of the described Chinese medicine composition in the medicine for preparing treatment endocrinopathy.

The present invention can be prepared into any conventional oral preparations, such as pill, powder, mouth using the conventional method of Chinese medicine preparation Take liquid, granule, capsule etc..For example preservative can be added to be made mouth by these bulk drug decoctings, through filtering to get filtrate Take liquid；Decoction can also be directly taken if necessary.The present invention can also be made tea bag on behalf of the tea, and exactly bulk drug of the present invention is pressed Fine particle shape being crushed or being cut into according to ratio requirement, parcel is bundled into paper or cloth after mixing, the used time is directly parcel Put into cup, pour boiling water into, add a cover stewing 10 minutes it is i.e. drinkable, bubble to tea it is light, wrap within one day two, wrap in the morning one, under Noon one wraps, and this on behalf of the tea can be with long-term taking.

Relative to prior art, the present invention has the advantage that：

1st, Chinese medicine composition of the present invention is the selected medicament composing prescription in the case where Traditional Chinese medical theory and clinical experience are instructed：Meat desert Rong's kidney-replenishing；Benefiting essence-blood；Ease constipation road；Rose had both entered qi leel and for example blood system, and energy promoting the circulation of qi menstruation regulating, and blood dissipates the stasis of blood；Through dialectical compatibility, Helped mutually assistant is used, kidney tonifying is played altogether and adjusts the treatment of liver, regulating the flow of vital energy Xie Yu, effect of promoting blood circulation to remove blood stasis, Endocrine imbalance to reach Treat both principal and secondary aspect of disease.The component of the present composition uses natural Chinese medicine material, and its preparation is easy, medicine source is wide, low cost.This hair The prescription that saline cistanche and rose are coordinated of person of good sense's novelty is used to treat the patient of endocrinopathy, achieves unexpected Effect.Verify by clinic application, its reliability evident in efficacy, mild in medicine property and, there is not toxic and side effect, total effective rate up to 93% with On, cure rate 60%.

2nd, rose of the invention and saline cistanche use source nitrogen hypoxemia heat pump drying and vacuum drying combined drying side Method is prepared.Including pre-treatment, rinsing drain, in source nitrogen heat pump drier dry, in vacuum drying chamber dry, it is close Envelope preserves step.Present invention reduces energy consumption for drying, improve drying efficiency, it is to avoid the phase dries effect to heat pump drying after the drying Rate is low, shortcoming long the time required to drying, and the effective medical material quanlity that avoids declines, the problem of color change.Present invention side Method can suppress the aldehydes matter oxidation generation quinone in medicinal material, reduce oxidational losses and the aroma volatile of active ingredient Volatilization loss, it is to avoid oxidation obtains the drying of natural in color to the infringement in terms of medicine materical crude slice color and luster and texture in drying process Product.Dried rosebud keeps original chromatic colour, farthest preserves its nutritional ingredient and health-care effect.This The advantage of invention is that dried rose bioactivity active ingredient destruction is minimum, and profile is intact, maintains rose Nutritional ingredient and active material, moisture content is low, is readily transported and stores for a long time.

3rd, in the preparation of desertliving cistanche sheet, the present invention breaks through the traditional understanding of prior art, is not eager not only to kill enzyme Treatment, on the contrary medicinal material is carried out physics prepare stimulate after, 25~45 DEG C in heat pump drier hothouse saline cistanche done It is dry to water content 20~30%, enzyme, drying are then killed again, medicine materical crude slice is made.Inventor the experiment proved that, the benzyl carbinol in saline cistanche Methods of glycosides medicinal material undergo it is post-stimulatory will not only be digested, on the contrary in content ascendant trend, just can gradually reduce afterwards. Therefore, to the physical stimulation that saline cistanche medicinal material is certain, and certain placement environment is provided, kills ferment treatment in time again afterwards, be Improve the key of desertliving cistanche sheet quality.With medicine materical crude slice process technology (the patent CN201410392733.4, section of existing saline cistanche → high temperature kills mould → drying) ratio, method for cold air drying of the invention is with advantage once：(1) active constituent content is high.Because of non-horse On carry out high temperature and kill ferment treatment, what saline cistanche occurred during cold air drying stress change is presented active ingredient gradually increases Trend, and drying temperature is low (be less than 45 degree), and active ingredient average content about improves 2 times.(2) the outward appearance matter of medicine materical crude slice is improve Amount.The most of moisture medicine materical crude slice that chip drying to specified degree is obtained again is first removed, unilateral smooth bright and clean journey is substantially increased Degree, it is to avoid first cut into slices and dry the major defect of the unilateral shrinkage injustice for causing afterwards.The medicine materical crude slice produced by the inventive method is sought Support and lose small, health environment-friendly.Determined through analysis, the leading indicator of desertliving cistanche sheet quality is weighed in the desertliving cistanche sheet for being harvested The content of composition echinacoside and mullein glucoside monomeric compound is up to 13%~24% (in terms of dry), than original technique High 2-5 times, moisture is less than 5%.Golden yellow or pitch black, soft texture in the desertliving cistanche sheet color that this technique makes.This hair It is bright with important application prospect and popularizing value.

Pharmaceutical Analysis：

Saline cistanche：It is orobanchaceae plant cistanche Cistanche deserticolaY.C.Ma or Cistanche tubulosa The fleshy stem of the dry zone scale leaf of Cistanche tubulosa (Schrenk) Wight.Saline cistanche be China it is traditional rare in Medicinal material, the title for having " desert ginseng ", itself also known as smart bamboo shoot, it is smart, first recorded in《Sheng Nong's herbal classic》, it is classified as top grade.It is sweet；It is salty；Property Temperature.Return kidney；Large intestine channel.Effect kidney-replenishing；Benefiting essence-blood；Ease constipation road.Cure mainly decline of kidney-YANG；Pain in the back flaccidity of lower limbs.《This warp》Carry：The main exhaustion or lesion of the five internal organs Seven kinds of impairments, bowl spares, except fever and chills bitterly, support the five internal organs, Qiang Yin, strengthening the essence gas in stem.《Collected statements on the herbal foundation》Carry：Temperature is mended without high without heat, warm up and It is not dry, it is sliding without letting out, therefore have calm name.Modern pharmacological research shows, saline cistanche in addition to as traditional tonifying kidney and strengthening yang Chinese medicine, Also there are various functions such as anti-oxidant, anti-aging, radioresistance, regulation immunity, enhancing memory.Saline cistanche can strengthen hypothalamus- The rush luteal function of pituitary and ovary, can make the weightening more obvious than control group of anterior pituitary of rat, ovary, uterus weight, improve hypophysis To the reactivity and the rush luteal function of ovary of LRH.

Rose：It is the dry flower or corolla of rosaceous plant rose Rosa rugosa Thunb..It is sweet；Slight bitter； Temperature；It is nontoxic.Return liver；The spleen channel.Regulating the flow of vital energy Xie Yu；Regulating menstruation by adjusting the flow of blood.Cure mainly：Chest diaphragm caused by stagnation of liver qi is full vexed, and gastral cavity side of body distending pain, breast is made It is swollen, irregular menstruation, dysentery, diarrhea, under band, traumatic injury carbuncle swells.《Food book on Chinese herbal medicine》：Main sharp lung spleen, beneficial liver and gall, the evil that exorcises evil spirits Gas, the fragrance of food is sweet and refreshing, makes us refreshing refreshing.《The property of medicine is examined》：The broken product of promoting circulation of blood, damages tired pain.《Detailed outline is picked up any lost article from the road》：Regulating and activating blood circulation, qi-regulating, Control wind thin.《Pseudo- medicinal strip is distinguished》：With blood regulating the qi flowing in the channels, soothing the liver is opened strongly fragrant.《Collection before herbal justice》Say：Rose, fragrance is most dense, clearly without Pond, and without violent, soft liver is waken up stomach, gas and blood, and a surname is logical to stop up stagnant, and the absolutely not just dry disadvantage of pungent-warm, disconnected to push away among qi leel medicine, is most had Victory effect, and person the most tractable, fragrant all product, idle nothing is very.《Book on Chinese herbal medicine is new again》：The strongly fragrant gas of liver and gall of relaxing, invigorating the spleen fall fire.Control cold in abdomen Bitterly, gastral cavilty product is cold, and can blood-breaking.Modern medicine study is proved：Flos Rosae Rugosae extract is to human immunodeficiency virus (AIDS disease Poison), leukemia virus and T cell leukemia virus have antivirus action.Attar of rose plays the role of to promote choleresis.Catechu Smart class material has nicotinic acid sample to act on, and can be used for the complex treatment of radiation sickness, and have antitumor action.Rose is the conventional grass of Uygurs Medicine, rose is mild-natured in Uygurs's medicine theory, with ripe exception bile matter and abnormal firewood liquid matter, resuscitation with aromatics, calms the nerves only Bitterly, soft intestines defaecation, nourishing stomach, improve digestion, wind dispelling anti-inflammatory, moisturizing and blaze function.

Specific embodiment

Embodiment 1：The preparation technology of desertliving cistanche sheet：

1) the saline cistanche fresh medicinal material of in April, 2016 excavation is taken, stem apex is removed.Plucked using stainless steel mesh screening Fresh herba cistanches, cleaning after draining, is cut to 2-4 parts, standby；

2) heat pump drier hothouse power supply is opened, the assisted heating device started in hothouse is preheated at least to hothouse 30min；Preheating terminates to be passed through nitrogen in backward hothouse, oxygen concentration in hothouse is reduced to 5-10%；Then by above-mentioned meat Desert cistanche is first uniformly spread on stainless steel mesh；The screen cloth that saline cistanche will be filled again is put in source nitrogen heat pump drier hothouse It is interior；Saline cistanche in heat pump drier hothouse is dried to water content 20~30%, Drying Technology Parameter is：Drying process In dry room temperature for 25~45 DEG C, wind speed of blast blower is 1~3m/s, and oxygen purity is 5 in hothouse in drying process ~10%；

3) after heat pump drying terminates, the screen cloth that will fill saline cistanche takes out, and cuts 3-5mm sheets, and water steams and kills at enzyme for 10 minutes Reason, then, to water content less than 10%, vacuum is 1~3KPa in hothouse to be placed in drying in vacuum drying chamber, drying temperature is 40~60 DEG C；

4) by compound valve bag of the dried saline cistanche piece loaded on LDPE materials, nitrogen charging makes bag internal oxygen concentration≤5% Sealing preserve afterwards.

The research of desertliving cistanche sheet preparation technology：

Evaluate saline cistanche quality mainly right《Chinese Pharmacopoeia》Set quota composition echinacoside and acteoside Amount is examined and determine, and modern age pharmaceutical research is also indicated that, the Echinacea purpurea former times and acteoside in the medicinal material can improve immunity of organism Function, promotes DNA synthesis, and enhancing muscle power improves intelligence, with obvious anti-aging effects.

First, experiment condition：

1st, liquid-phase condition：

Instrument：The liquid chromatographs of Thermo Ultimate 3000；Chromatographic column：Agilent XDB-C18column (5 μm, 4.6×250mm)；Column temperature：30℃；Flow velocity：1mL/min；Sample size：10μL；

Mobile phase：The formic acid water of methyl alcohol -0.1%, gradient elution；

Elution program：0-30min:30%-40%；30-35min:40%-30%；35-40min:30% methyl alcohol.

2nd, the preparation method of need testing solution：Precision weighs the dry saline cistanche sample powders of 1g (crossing 50 mesh sieves), puts In 50mL conical flask with cover, 70% methyl alcohol 50mL is added, weighed, soak 30min, weight is re-weighed and supplied after ultrasonic 30min, Standing takes extract solution 1mL after letting cool, filtration, takes supernatant and crosses 0.45 μm of miillpore filter, is stored in 4 DEG C of refrigerators, standby.

3rd, the preparation method of reference substance solution：Precision weighs echinacoside, cistanoside A, acteoside, 2 '-acetyl Base acteoside each 15.0,10.0,12.0,10.0mg, to put in same 50mL measuring bottles and dissolved with 70% methyl alcohol and be diluted to quarter Degree, is stored in 4 DEG C of refrigerators, standby.

4th, assay method：Each 10 μ L of above-mentioned need testing solution, reference substance solution are taken, liquid chromatograph analysis is injected separately into, Obtain final product.

2nd, experiment content and method：

1st, the comparing of different drying means

4 parts will be divided into after fresh herba cistanches rip cutting, 1 part of directly freezed therein is dried, 5 parts are respectively adopted day in addition Light is exposed to the sun, dries naturally, heat pump drying, vacuum drying and normal pressure oven drying method are dried.The active ingredient in 6 parts of samples is determined respectively Content, as a result see the table below.

Active constituent content (mg/g) in the different furnace drying method saline cistanche sections of table 1

Result shows：In the case where not taking and killing enzymatic process, several drying means can cause the obvious of active ingredient Reduce, but solar exposure method is substantially better than with heat pump drying method, method is dried naturally and normal pressure oven drying method, vacuum drying method is taken second place.

2nd, influence of the different seasonings to saline cistanche active constituent content

Experiment finds in the early-stage Study (patent 201410392733.4) of inventor：Saline cistanche active constituent content exists Maximum is reached during storage 4-6 days, occur within 6 days substantially decaying afterwards and medicinal material has and substantially goes mouldy.Then air blast drying is carried out again, is deposited Long in the process time, the low problem of efficiency, the present invention is improved experiment using heat pump drying technique.

2 parts will be divided into after fresh herba cistanches rip cutting, wherein 1 part of uniform spreading do on stainless steel mesh, being put in heat pump In dry machine hothouse, it is dried that (Drying Technology Parameter is to saline cistanche in heat pump drier hothouse：Drying temperature be 40~ 50 DEG C, wind speed of blast blower be 1~2m/s, in hothouse oxygen purity be 5~10%), part is taken out at regular intervals Sample cuts sheet freeze-drying, and as a result the active constituent content in determination sample see the table below 2.Another is in room temperature condition After (18-25 DEG C) is placed 5 days, then air blast drying is carried out with 70 DEG C, sample segment is taken out at regular intervals to cut sheet freezing Dry, as a result the active constituent content in determination sample see the table below 3.

To active constituent content situation of change (mg/g) in saline cistanche during the heat pump drying of table 2

From the result of table 2：Inventor the experiment proved that the phenylethanoid glycoside in saline cistanche undergoes section in medicinal material Will not only be digested after the physical stimulation of good heat pump drying, on the contrary in content ascendant trend, just can gradually reduce afterwards.Respectively Active constituent content changes in drying process in tendency, and wherein echinacoside, cistanoside A content become in faint decline Gesture, but intensity of variation is weaker；And acteoside and the change of 2 '-acetyl group acteoside are obvious, content is in substantially first quick The slow trend for reducing after increase, sample increasess slowly after 12h is dried, and during to 24h, medicinal material content reaches highest.From heat pump Dry time and water content result can be seen that heat pump drying after drying 12 hours, and drying efficiency declines substantially, is dried to Water content is can be only achieved after 72 hours below 10%, in addition it is also necessary to which drying process is improved, improve drying efficiency.

The room temperature of table 3 place 5 days after in drying course to active constituent content situation of change (mg/g) in saline cistanche

From the result of table 3：Sample room temperature place 5 days after in drying course each active constituent content in drying process Change in tendency, wherein echinacoside, cistanoside A content are on a declining curve, compared with heat pump drying technique, its change journey Degree is very fast；And acteoside and the change of 2 '-acetyl group acteoside are obvious, content is in the slow trend for reducing.From drying Time and water content result can be seen that forced air drying after drying 48 hours, and water content is close to 10%, and its drying effect is obvious It is poorer than heat pump drying.

3rd, influence of the different combined drying methods to saline cistanche active constituent content

Heat pump drying has stronger advantage in low temperature drying, but the heat pump drying found in experiment is drying the middle and later periods There is slow drying speed, the drawbacks of drying time is long；Therefore heat pump can be combined with vacuum drying, constant pressure and dry etc..

4 parts will be divided into after fresh herba cistanches rip cutting, be placed in heat pump drier hothouse and be dried to doing very likely Make water content up to 20~30%, Drying Technology Parameter is：It is 40~45 DEG C that room temperature is dried in drying process, and wind speed of blast blower is 1~3m/s；After heat pump drying terminates, the screen cloth that will fill saline cistanche takes out, and cuts 3-5mm sheets, and water steams and kills ferment treatment in 10 minutes, It is divided into three parts, micro-wave drying method, 70-80 DEG C of normal pressure alternated blasting and 50-60 DEG C of boulton process is respectively adopted and is dried to containing Water is less than 10%, and as a result separately sampled, the active constituent content in determination sample see the table below 4.

Active constituent content (mg/g) in the saline cistanche section of the different combined drying methods of table 4

Result shows：Heat pump is used in the initial drying stage of material, heat pump is given full play to and is dehumidified in low temperature drying soon Again the characteristics of energy-conservation, and other modes are selected in the middle and later periods of dry materials, so as to be contracted in the whole drying process of material Short drying time, reach energy-efficient purpose.Heated-air drying there is the thermal efficiency and energy utilization rate is low, dried product is of poor quality The problems such as.Although the microwave drying thermal efficiency is high, dried product quality preferable, drying process is difficult to control to, and is easily caused heat waste Evil product quality, occurs burning, is gelatinized and case-hardened phenomenon, causes component content to reduce.Therefore the present invention uses heat pump Seasoning and vacuum drying method combined drying technique carry out the preparation of saline cistanche.

The present invention breaks through the traditional understanding of prior art, is not eager not only to kill ferment treatment, is carrying out thing to medicinal material on the contrary After reason stimulates (rip cutting or crosscutting then carry out heat pump drying again), enzyme is then killed again, is vacuum dried, is made medicine materical crude slice.Inventor is through reality Checking is bright, and the phenylethanoid glycoside in saline cistanche will not only be digested in medicinal material after stimulated, rises in content on the contrary Trend, just can gradually reduce afterwards.Therefore, to the physical stimulation that saline cistanche medicinal material is certain, kill ferment treatment in time again afterwards, be Improve the key of desertliving cistanche sheet quality.

Embodiment 2：The preparation technology of rose medicine materical crude slice：

1) rose (RosarugosaThunb.) is collected in Xinjiang Wo Lin Eco Science Technologies Co., Ltd rose plant garden.Flower The harvesting of flower bud：Parted a little with calyx point, flower bud point is rubescent, a bud just ready to burst before for pluck best period.Standard of plucking is fully swollen Big but unopened bud.The new fresh-rose plucked using stainless steel mesh screening, removes blade and the rose for having opened；Flower The harvesting of hat：In morning 4-6 points, semi-open flower is plucked.

2) heat pump drier hothouse power supply is opened, the assisted heating device started in hothouse is preheated at least to hothouse 30min；Preheating terminates to be passed through nitrogen in backward hothouse, oxygen concentration in hothouse is reduced to 5-10%；Then by above-mentioned step Rapid 1) rose is first uniformly spread on stainless steel mesh, and loading capacity is 1-3.5kg/m², thickness is 0.5-3cm；To fill again The screen cloth of rose is put in source nitrogen heat pump drier hothouse, at a distance of 15-30cm between neighbouring two-layer screen cloth；

3) 4~8h is dried to rose in heat pump drier hothouse, Drying Technology Parameter is：Done in drying process Dry room temperature be 30~50 DEG C, wind speed of blast blower be 1~2m/s, in drying process in hothouse oxygen purity be 5~ 10%；

4) after heat pump drying terminates, the screen cloth that will fill rose takes out, and is placed in and 2~4h is dried in vacuum drying chamber, does Dry house vacuum degree is 1~3KPa, and drying temperature is 40~60 DEG C；

5) gained rose is uniform after vacuum drying terminates spreads in shady and cool, clean, ventilation tempering；Described tempering side Method is to be spread rose, spreads density for 2-5kg/m², thickness is 2-5cm, spreads the time for 4-8h.

6) rose after tempering is loaded in the compound valve bag of LDPE materials, after nitrogen charging makes bag internal oxygen concentration≤5% Sealing preserve.

The research of dried rose flower drying process：

Rose contains volatile oil about 0.03%, mainly containing citronellol, up to 60%.The comparison of ingredients of natural rose oil is answered Miscellaneous, including alcohols, acids, esters, terpenes and alkanes etc., monoterpenes compound occupies very big ratio, such as citronellol, inner That alcohol, geraniol etc. belong to such；Secondly aliphatic compound and alkanes content are also more；The oxygen-containing chemical combination of other monoterpene Thing has not replaceable contribution to the structure composition of rose aroma, such as rose oxide, benzene derivative, sesquiterpene and its containing oxidation Compound etc..Rose contains abundant flavonoid glycoside composition, wherein the various glycosides with Quercetin and Kaempferol as aglycon are up to Ten is several, and flavonoid glycoside has various excellent pharmacological activity, the anti-cardiovascular disease of rose, hepatic cholagogic, anti-inflammatory antioxygen The pharmacological actions such as change are largely relevant with the flavones ingredient that it contains.The polyphenol compound that rose contains is not only With oxidation that is anti-oxidant, removing free radical, suppress low-density lipoprotein and the effect of prevention cardiovascular and cerebrovascular disease, but also With functions such as anticancer, anti-inflammatory and anti-platelet aggregations.Therefore, it is the validity of guarantee medication, this measuring rose Middle fragrance component, general flavone and Determination of Polyphenols, preferably to control the quality of rose, it is ensured that curative effect.

First, experiment condition：

(1) measure of fragrance component：GC-MS-PDMS (SPME-gas phase-MS) method is referring to hereafter Offer：Su Hongxia；Edible rose preservation technology and its oral liquid Study on Preparation [D]；Shandong Light Ind College；Master in 2012 Academic dissertation.

(2) measure of general flavone content

The preparation of reference substance solution：It is accurate to weigh during 60 DEG C of dryings put 25ml volumetric flasks to the rutin standard items 5mg of constant weight, Plus 60% ethanol dissolve and dilute and be settled to scale, shake up, obtain final product.

Standard curve is formulated:Precision is drawn control substance of Rutin solution 1ml, 2ml, 3ml, 4ml, 5ml, 6ml and is respectively placed in In 25ml volumetric flasks, the NaNO for plus 5%₂Solution 1ml, places 6min, the Al (NO for plus 10%₃)₃1ml, shakes up, and places 6min, plus 4% NaOH solution 10ml, plus 60% ethanol shakes up to scale, places 15min；With corresponding solution as blank, according to it is ultraviolet- Visible spectrophotometry (A of annex V), the mensuration absorbance at 510nm wavelength, with absorbance as ordinate, concentration is as abscissa Draw standard curve.Regression equation is：Y=11.204x+0.0057, r=0.9997 (n=8), the range of linearity be 8.00~ 64.00μg/ml。

The preparation of need testing solution：Take and dry conical flask, precision weighs the rose flower of about 0.5g, with 70% ethanol It is Extraction solvent, 40 DEG C of ultrasonic extraction 25min, solid-liquid ratio is 1:30；Suction filtration, with petroleum ether extraction three times, after vacuum distillation To rose general flavone crude extract sample, dissolved with respective concentration ethanol, filtrate is diluted to respective concentration ethanol after suction filtration 25ml, as test liquid.Precision draws each test liquid 1ml, is respectively placed in 25ml volumetric flasks, under sighting target directrix curve preparation Method, mensuration absorbance, and general flavone concentration is calculated according to working curve, obtain the content of general flavone in rose.

(3) measure of Determination of Polyphenols

Determined using ferrous tartrate method, referring to document：Zhang Xuelian rose flower polyphenols isolate and purify and its feature drink Research [D] the Guangzhou of material：South China Normal University, 2007., with gallic acid as standard sample, standard curve is drawn, with minimum Square law makees linear regression, obtains the regression equation of polyphenol content Y and the relation curve of absorbance A：Y=2.2402X- 0.0083, r=0.9987, calculate Determination of Polyphenols.

The vacuum freeze drying of rose can to greatest extent keep color, shape and the structural constituent of roseleaf, obtain The product of high-quality is obtained, is comparatively ideal drying means.But vacuum freeze drying power consumption is big, and the production cycle is long, disposable to throw Money is big, and maintenance and maintenance cost are high.Although the microwave drying thermal efficiency is high, dried product quality preferable, drying process is difficult to control System, was easily caused pyrolytic damage product quality, occurs burning, is gelatinized and case-hardened phenomenon.The present invention is ripe using industrialization Hot-air drying technology, vacuum drying process, heat pump drying technique carry out experimental study.

2nd, experiment content and method：

1. influence of the different drying processes to the fragrance ingredient, total polyphenols and general flavone content of rose.

The rose of half-open phase is selected, in morning l0：00 or so collection, select it is uniform in size, without insect pest, it is new without what is rotted Used as experiment material, the rose after adopting is respectively adopted following drying means treatment to fresh-rose：1. 60 DEG C of hot-air seasonings；②50 DEG C vacuum drying；3. heat pump drying, Drying Technology Parameter is：It is 40 DEG C that room temperature is dried in drying process, and wind speed of blast blower is 1.5m/s, oxygen purity is 5~10% in hothouse in drying process；4. Indoor Natural dries in the shade.Each treatment is all provided with 3 times Repeat, after each sample drying to constant weight, pulverize and sieve, analysis determines fragrance ingredient, total polyphenols, general flavone content, to determine most Good drying means.

Result of the test：

General flavone, the content of total polyphenols in the different drying means roses of table 5

Result shows：Heat pump drying rose not only shortens drying time in 40 DEG C of low temperature dryings, reaches efficiently section Can the characteristics of, and in dry product general flavone, total polyphenols content highest.The active ingredient of boulton process is taken second place.

Fragrance evaluation result in the different drying means roses of table 6

From upper table result can be seen that heat pump drying and vacuum drying after the exterior quality of rose dry product be significantly better than Naturally the dry product dried in the shade with heated-air drying.

Main fragrance ingredient content (μ g/L) in the different drying means roses of table 7

From upper table result can be seen that rose in citronellol, geraniol, bata-phenethyl alcohol and rose quality in just Dependency relation, and eugenol is presented negative correlativing relation with the quality of rose.Rose after heat pump drying and vacuum drying The fragrance ingredient total content of dry product is significantly better than the dry product dried in the shade naturally with heated-air drying.Fragrance ingredient content and fragrance evaluation knot Fruit is consistent.

In sum, heat pump drying and vacuum dehydrating at lower temperature method can effectively avoid the problem of medicinal material color change.Should Drying means can suppress the aldehydes matter oxidation generation quinone in medicinal material, and the oxidational losses and fragrance ingredient for reducing active ingredient are waved Hair loss, it is to avoid oxidation obtains the drying product of natural in color to the infringement in terms of medicine materical crude slice color and luster and texture in drying process Product.

2nd, influence of the combined drying method to rose active constituent content

Heated-air drying there are problems that the thermal efficiency and energy utilization rate is low, dried product, and lot of experiments finds rose Flower at 40 DEG C heated-air drying 55h water content up to 15%, outside petal zoom, and inside is still moister.Heat pump drying There is stronger advantage in low temperature drying, but there is slow drying speed drying the middle and later periods in the heat pump drying found in experiment, The drawbacks of drying time is long；Such as rose heat pump drying 4h at 40 DEG C, the moisture content of rose is dried up to 15% in the later stage During the time it is more long.In view of vacuum drying effect is also good, holder and the complete broken degree of drying of calyx are attained by, by upper State experiment and understand that vacuum drying has preferable mode of appearance and active constituent content, therefore can be by heat pump and vacuum drying phase With reference to carrying out technical study.

Test method：The rose of half-open phase is selected, in morning l0：00 or so collection, select it is uniform in size, without insect pest, Without rotten new fresh-rose as experiment material, the rose after adopting is respectively adopted following drying means treatment：1. first carry out 30 DEG C of heat pump dryings, Drying Technology Parameter is：Wind speed of blast blower is 1.5m/s, oxygen purity in hothouse in drying process It is 5~10%；Transferring to vacuum drying chamber carries out 40 DEG C of vacuum drying；2. 40 DEG C of heat pump dryings, drying process ginseng are first carried out Number is：Wind speed of blast blower is 1.5m/s, and oxygen purity is 5~10% in hothouse in drying process；Transfer to vacuum Drying box carries out 50 DEG C of vacuum drying；3. 50 DEG C of heat pump dryings are first carried out, Drying Technology Parameter is：Wind speed of blast blower is 1.5m/ S, oxygen purity is 5~10% in hothouse in drying process；Transferring to vacuum drying chamber carries out 60 DEG C of vacuum drying； Each treatment is all provided with 3 repetitions, after each sample drying to constant weight, pulverizes and sieves, and analysis determines fragrance ingredient, total polyphenols, total Huang Ketone content, to determine optimum drying method.

Result of the test：

General flavone, Determination of Polyphenols (mg/g) in the rose section of the different combined drying methods of table 8

Fragrance evaluation result in the different combined drying method roses of table 9

Main fragrance ingredient content (μ g/L) in the different combined drying method roses of table 10

Result shows：Heat pump is used in the initial drying stage of material, heat pump is given full play to and is dehumidified in low temperature drying soon Again the characteristics of energy-conservation, and other modes are selected in the middle and later periods of dry materials, so as to be contracted in the whole drying process of material Short drying time, energy-efficient purpose is reached, holder and the complete broken degree of drying of calyx can be reached, final moisture content is low In 8%.Therefore the present invention carries out the preparation of rose medicine materical crude slice using heat pump drying method and vacuum drying method combined drying technique.

The method of comprehensive drying rose of the present invention, rose is first placed into heat pump drier, at the beginning of carrying out the dehumidifying stage Dry, remove the most moisture in rose, then reuse vacuum drier and remove remaining moisture.Two kinds of drying modes Effective combination, both avoided long the time required to hot air circulation is dried, temperature is high, high energy consumption, it is dry spend middle outer layer petal with Internal layer petal aridity is inconsistent, the excessive dehydration of outer layer petal and it is easily damaged, internal layer petal is difficult to dry excess moisture and color Jaundice；Turn avoid the loss and volatilization of active ingredient.Also, two kinds of drying modes are combined, low-temperature short-time is dried can be obtained Rose to moisture less than 8%, the active ingredient in bud is able to farthest preserve, bud outward appearance and quality compared with It is high；The outer layer petal of gained rose dried flower flower bud is consistent with the aridity of internal layer petal, and color fickle in love is normal, the loss of active principle It is few.

Embodiment 3：The preparation of tea bag

1) rose and saline cistanche prepared by Example 1 and 2, is respectively crushed into 20 mesh powder, standby；

2) by formula saline cistanche：Rose=3：1, rose and saline cistanche powder are weighed, filled with three-dimensional motion mixer Divide mixing 15 minutes, tea bag, every bag of 12g are made after metering packing.

Embodiment 4：The preparation of tea bag

1) rose and saline cistanche prepared by Example 1 and 2, is respectively crushed into 20 mesh powder, standby；

2) by formula saline cistanche：Rose=2：1, rose and saline cistanche powder are weighed, filled with three-dimensional motion mixer Divide mixing 20 minutes, tea bag, every bag of 15g are made after metering packing.

Embodiment 5：The preparation of tea bag

1) rose and saline cistanche prepared by Example 1 and 2, is respectively crushed into 20 mesh powder, standby；

2) by formula saline cistanche：Rose=1：1, rose and saline cistanche powder are weighed, filled with three-dimensional motion mixer Divide mixing 15 minutes, tea bag, every bag of 10g are made after metering packing.

Embodiment 6：The preparation of powder or tea bag

Saline cistanche will be formulated：Rose=2：1 new fresh-rose and fresh herba cistanches, picks impurity, cleaning, drains, After draining, plus 10 times the 70% of amount of ethanol solution refluxing extraction 3 times, extract 2 hours every time, merge extract solution and reclaim second Alcohol, concentration, dry, pulverize prepared dried cream powder；Plus the starch mixing of 1 times of amount of dried cream powder, particle is made of granulator granulation, prepare Into tea bag, powder or granule.

Test example：Clinical research：

1st, general data：

60 clinical observations of endocrine disturbance patient that selection The First Affiliated Hospital of Guangzhou University of Traditional Chinese Med makes a definite diagnosis, Bing Rensui Machine is divided into two groups.Treatment group 30,26~50 years old age, average age 37.6 years old, man 5, female 25.Control group 30, year 27~52 years old age, average age 36.4 years old, man 6, female 25,.Two groups of qualifications and record of service are basically identical, without significant difference, with comparable Property.

2nd, diagnosis basis：With reference to People's Republic of China's traditional Chinese medicine industry standard《Chinese medical disease Standardization of diagnosis and curative effect》In it is interior The diagnostic criteria of dyssecretosis：

1) emotional factor：When there is the sudden variation of mood, it is often desire to fly into a rage；

2) external feature：There is color spot in face, and skin conditions deteriorate；

3) it is long-term infertile：Endocrine disturbance can influence the secretion of estrogen, cause female acyesis；

4) white hair early ageing：Seem excessive aging, basic and actual age is not inconsistent, alopecia early ageing.

3rd, treatment group patient takes the medicine of the preparation of the embodiment of the present invention 2 on behalf of the tea, wraps within one day two, and wrap in the morning one, afternoon One bag, 2 weeks is a course for the treatment of, takes 3 courses for the treatment of.Control group gives tradition according to the classification of the female endocrinic disorders being diagnosed to be The treatment means such as doctor trained in Western medicine hormone control.

4th, criterion of therapeutical effect：With reference to People's Republic of China's traditional Chinese medicine industry standard《Chinese medical disease Standardization of diagnosis and curative effect》In Endocrinopathy efficacy assessment standard：Recovery from illness：Symptom disappears, and sign is normal；It is effective：Symptom mitigation, sign has taken a turn for the better；Have Effect：Symptom has mitigated, and sign is without being clearly better；It is invalid：, without improvement, sign is without improvement for symptom.

5th, therapeutic effect：Cure 18 in treatment group, take a turn for the better 10, invalid 2, cure rate 60%, total effective rate 93.3%.Cure 9 in control group, take a turn for the better 12, no effect 9, cure rate 30%, total effective rate 70%.Result above shows, The cure rate and total effective rate for the treatment of group are apparently higher than control group.

Typical case：

Case 1：Zhang, man, 45 years old.Patient's private prosecution：It is often desire to fly into a rage, is off one's feed, sexual hypoesthesia, it appears that than real The border age is old much.It is diagnosed as：Endocrinopathy.Take 2 courses for the treatment of of medicament prepared by Chinese medicine composition of the present invention, the state of mind It is clearly better, appetite, sexual desire are obviously improved；Continue to take 2 courses for the treatment of, symptom and sign disappear, cure.Follow-up half a year is not multiple Hair.

Case 2：Wang, female, 33 years old.Administrative class work is engaged in, in recent years, chloasma faciei gradually increases, and skin is dark yellow, And excessively aging appearance not only has influence on her social interactions, also allow her exceptionally injured in emotion, by diagnosis, its Chloasma on the face is mainly what is caused by endocrinopathy, and during pregnancy, human body endocrine there occurs huge change, cause face Portion's cutaneous pigmentation；During work, enough rests and sleep, cutaneous eubolism are lacked again；In life, feelings Thread is not good enough, causes the functional disturbance of other organs of body, causes skin function to decline yet.Introduced by friend, one is opened to Wang A little medicines of the present invention on behalf of the tea, are wrapped for one day two, and wrap in the morning one, and wrap in the afternoon one, and after Liu drinks one month, chloasma faciei is gradually Thin out, some even disappear, and also progressively light is light for skin of face, and after continuing to take one month, Liu's chloasma faciei is Through disappearing, the colour of skin also turns pale.

Case 3：Lee, female, office department civilian, responsible work is exactly daily, in face of computer, to write and printed material, Long-term work is got off, and the spot of face is more and more, and more and more substantially, if daily not crocus bottom lives spot all dare not Go out.Under the recommendation of friend, present inventor opens some medicines of the present invention on behalf of the tea to Lee, wraps within one day two, the morning one Bag, wraps afternoon one, and after drinking 20 days, facial spot fades away, and continues to drink 10 days, and facial spot is wholly absent, the colour of skin It is ruddy glossy.

Case 4：Ma, female, 30 years old, patient's readme, daytime will go to work, and will attend class and learn and look after the children in the evening, daily 4-6 hours can only be slept, recently normal small pox long on the face, and unsound jaundice blacks, and menstruation is also abnormal.After carrying out institute's interrogation, Female endocrinic disorders are diagnosed as, through taking invention medicine 1 month on behalf of the tea, above-mentioned symptom disappears substantially, complexion Improve, the state of mind improves, fully recovered.

The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all it is of the invention spirit and Any modification, equivalent for being made within principle etc., should be included within the scope of the present invention.

Claims (9)

1. a kind of Chinese medicine composition for treating endocrinopathy, it is characterised in that the Chinese medicine composition by following parts by weight medicine Thing is prepared from：Saline cistanche 10-30 parts, rose 3-10 parts.

2. it is according to claim 1 treatment endocrinopathy Chinese medicine composition, it is characterised in that the Chinese medicine composition with The medicine preparation of lower parts by weight is formed：Saline cistanche 15-25 parts, rose 4-8 parts；Preferably 18 parts of saline cistanche, rose 6 Part.

3. it is according to claim 1 treatment endocrinopathy Chinese medicine composition, it is characterised in that the Chinese medicine composition adds Enter acceptable auxiliary material or be not added with auxiliary material and be made clinically acceptable formulation, the formulation be tea bag, powder, granule, Tablet, capsule or oral liquid.

4. it is a kind of it is as claimed in claim 3 treatment endocrinopathy Chinese medicine composition preparation method, it is characterised in that bag Include following steps：

A) new fresh-rose is prepared into rose medicine materical crude slice through source nitrogen heat pump drying and vacuum drying, it is standby；The rose It is the dry flower or corolla of rosaceous plant rose Rosa rugosa Thunb.；

B) desertliving cistanche sheet is prepared into through source nitrogen heat pump drying and vacuum drying after fresh herba cistanches are first cut into slices, it is standby；

C) above-mentioned rose and desertliving cistanche sheet are taken, 20-100 mesh powder is respectively crushed into, it is standby；By formula weigh rose and Saline cistanche powder, is sufficiently mixed 10~25 minutes with three-dimensional motion mixer, by recipe quantity loaded on brewing in bag, is made bag bubble Tea；

D) or not carry out pulverization process, take step a) and b) obtained by rose and desertliving cistanche sheet, directly by recipe quantity fill In brewing in bag, tea bag is made.

5. it is a kind of it is as claimed in claim 3 treatment endocrinopathy Chinese medicine composition preparation method, it is characterised in that bag Include following steps：By the new fresh-rose and fresh herba cistanches of recipe quantity, impurity is picked, cleaned, drained, after draining, plus 10- 15 times the 60~80% of amount of ethanol solution refluxing extraction 2-3 times, extracts 1-2 hours every time, merges extract solution and reclaims ethanol, dense Contracting, dry, pulverize prepared dried cream powder；Plus appropriate amount of auxiliary materials is made particle with granulator granulation, tea bag, powder, particle are prepared into Agent, tablet, capsule.

6. it is according to claim 4 treatment endocrinopathy Chinese medicine composition preparation method, it is characterised in that it is described Rose medicine materical crude slice step of preparation process it is as follows：

1) the new fresh-rose plucked using stainless steel mesh screening, removes blade and the rose for having opened, standby；

2) heat pump drier hothouse power supply is opened, the assisted heating device started in hothouse is preheated at least to hothouse 30min；Preheating terminates to be passed through nitrogen in backward hothouse, oxygen concentration in hothouse is reduced to 5-10%；Then by above-mentioned step Rapid rose 1) is first uniformly spread on stainless steel mesh；The screen cloth that rose will be filled again is put in source nitrogen heat pump drier In hothouse；

3) 4~8h is dried to rose in heat pump drier hothouse, Drying Technology Parameter is：Hothouse in drying process Temperature is 30~50 DEG C, and wind speed of blast blower is 1~2m/s, and oxygen purity is 5~10% in hothouse in drying process；

4) after heat pump drying terminates, the screen cloth that will fill rose takes out, and is placed in and 2~4h, hothouse are dried in vacuum drying chamber Interior vacuum is 1~3KPa, and drying temperature is 40~60 DEG C；

5) gained rose is uniform after vacuum drying terminates spreads in shady and cool, clean, ventilation tempering；

6) by compound valve bag of the rose after tempering loaded on LDPE materials, nitrogen charging is sealed after making bag internal oxygen concentration≤5% Preserve.

7. it is according to claim 4 treatment endocrinopathy Chinese medicine composition preparation method, it is characterised in that：Step 5) in, described tempering method is to be spread rose, spreads density for 2-5kg/m², thickness is 2-5cm, when spreading Between be 4-8h.

8. it is according to claim 5 treatment endocrinopathy Chinese medicine composition preparation method, it is characterised in that it is described Desertliving cistanche sheet step of preparation process it is as follows：

1) using the fresh herba cistanches of stainless steel mesh screening excavation, cleaning after draining, is cut to 2-4 parts, standby；

2) heat pump drier hothouse power supply is opened, the assisted heating device started in hothouse is preheated at least to hothouse 30min, preheating terminates to be passed through nitrogen in backward hothouse, oxygen concentration in hothouse is reduced to 5-10%；；Then by above-mentioned meat Desert cistanche is first uniformly spread on stainless steel mesh；The screen cloth that saline cistanche will be filled again is put in source nitrogen heat pump drier hothouse It is interior；Saline cistanche in heat pump drier hothouse is dried to dry very likely makes water content up to 20~30%, drying process ginseng Number is：It is 25~45 DEG C that room temperature is dried in drying process, and wind speed of blast blower is 1~3m/s；Oxygen purity in hothouse It is 5~10%；

3) after heat pump drying terminates, the screen cloth that will fill saline cistanche takes out, and cuts 3-5mm sheets, and water steams and kills ferment treatment in 10 minutes, then It is placed in vacuum drying chamber and dries to water content less than 10%, vacuum is 1~3KPa in hothouse, drying temperature is 40~60 ℃；

4) by compound valve bag of the dried saline cistanche piece loaded on LDPE materials, nitrogen charging makes close after bag internal oxygen concentration≤5% Envelope is preserved.

9. application of a kind of Chinese medicine composition according to claim 1 in the medicine for preparing treatment endocrinopathy.