CN106692260A - Pharmaceutical composition used for treating upper respiratory infection, and applications thereof - Google Patents
Pharmaceutical composition used for treating upper respiratory infection, and applications thereof Download PDFInfo
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- CN106692260A CN106692260A CN201510794471.9A CN201510794471A CN106692260A CN 106692260 A CN106692260 A CN 106692260A CN 201510794471 A CN201510794471 A CN 201510794471A CN 106692260 A CN106692260 A CN 106692260A
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Abstract
The invention relates to a pharmaceutical composition used for treating upper respiratory infection, and applications thereof. The pharmaceutical composition used for treating upper respiratory infection is prepared from, by mass, 30 to 60% of rhododendron anthopogonoide extract, 20 to 50% of arenaria kansuensis extract, 20 to 50% of cordyceps militaris bacterial powder. The pharmaceutical composition is capable of clearing lung heat, eliminating phlegm, relieving cough, relieving asthma, and improving body immunity, and is used for treating symptoms such as cold, laryngitis, pharyngoconjunctival fever, bacterial pharyngitis, and bacterial tonsillitis caused by upper respiratory infection.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of pharmaceutical composition for treating the infection of the upper respiratory tract and its application.
Background technology
The infection of the upper respiratory tract is a kind of incidence of disease disease higher, and clinical manifestation is heating, headache, pharyngalgia, sneeze, nasal obstruction, runny nose, cough, expectoration
Etc. symptom.Rhododendron anthopogonoide is cold in nature, bitter, the effect of detumescence with clearing heat and detoxicating, relieving cough and asthma, stomach invigorating；Kansu sandwort herb has bitter cold, in clearing lung-heat it
Heat, cough-relieving, hypotensive, nourishing；Control the drug effects such as pneumonia, gonorrhoea, scrofula, hysteropathy；Cordyceps sinensis have invigorate the lung and the kidney, stop blooding, resolving sputum
Effect, for chronic cough and dyspnea of deficiency type, labor is coughed spitting of blood；Due to natural and artificial, its resource and yield are declining and expensive.Bat
Moth is that aweto mycelium fermentation is obtained by hair spore bacterium powder, is the substitute of Cordyceps sinensis, and it has the features such as price is relatively low, and yield is high.
Rhododendron extract, kansu sandwort herb extract and Hirsutella hepiali Chen et Shen powder are combined, cooperate with their drug effect, for treating the upper respiratory tract
Infection.
The content of the invention
The technical problem to be solved in the invention is in overcoming the shortcomings of background technology, there is provided a kind of pharmaceutical composition for treating the infection of the upper respiratory tract and its should
With.
The present invention is to be combined Rhododendron extract, kansu sandwort herb extract and Hirsutella hepiali Chen et Shen powder, cooperates with its drug effect, strengthens drug effect, is carried
For a kind of pharmaceutical composition for treating the infection of the upper respiratory tract.
Rhododendron anthopogonoide tender leaf and spray are cut into the preparation method of Rhododendron extract 1-3 centimetres of segment, are extracted with 0-75% ethanol, solid-liquid ratio 1:
5-15, temperature is 20-65 DEG C, and extraction time 2-5 times merges extract solution, is concentrated under reduced pressure, and 20-65 DEG C of temperature is dried：It is forced air drying, true
Vacuum freecing-dry, microwave drying, spray drying
The preparation method of kansu sandwort herb extract dries in the shade kansu sandwort herb, crushes, and is extracted with 0-75% ethanol, solid-liquid ratio 1: 5-20,20-70 DEG C of temperature, extracts secondary
Number 2-5 times, extract solution merges, and is concentrated under reduced pressure, and 20-70 DEG C of temperature is dried：Forced air drying, vacuum freeze drying, microwave drying, spraying are dry
It is dry.
Hirsutella hepiali Chen et Shen powder is the qualified products for meeting safety and sanitation standard commercially.
Above-mentioned three kinds of raw materials are matched by following mass percents, Rhododendron extract：30-60%, kansu sandwort herb extract：20-50%, bat moth
By hair spore bacterium powder：20-50%.For treating heating, headache, pharyngalgia, sneeze, nasal obstruction, runny nose, cough, expectoration that the infection of the upper respiratory tract causes
Deng disease.
Embodiment
1st, hoopoe army, Yu Dequan are studied rhododendron anthopogonoide alcohol extract, and the antiinflammatory action active component for as a result showing rhododendron anthopogonoide alcohol extract is chloroform portion
Position and ethyl acetate extract, and in isolated 9 triterpene compounds of chloroform extract.Its experimental technique is by dry rhododendron anthopogonoide stem, Ye Yong
95% alcohol reflux extracts 3 times (each 1h), merges extract solution, is concentrated under reduced pressure, and obtains total medicinal extract, and medicinal extract is suspended in water, and stone is used successively
Oily ether, chloroform, ethyl acetate are extracted repeatedly, and combining extraction liquid is simultaneously concentrated under reduced pressure, and that distinguishes extracts position, second to petroleum ether extraction position, chloroform
Acetoacetic ester extracts position, and chloroform is extracted into silicagel column on position, is eluted with petroleum ether-acetone system, before gained four parts cross repeatedly silicagel column,
Sephadex LH-20, obtain 9 compounds.
2nd, the analgesic activity to kansu sandwort herb extractive total flavone measure and to mouse such as Gong Shouji is studied.The kansu sandwort herb herb that it will pick up from Tibet is used
Water is extracted, D101 macroreticular resins on Aqueous extracts, is washed to distillation colourless；With 30% ethanol elution, eluent and concentrate drying are collected, obtained
C012 positions；With 60% ethanol elution, eluent and concentrate drying are collected, obtain C013 positions.The mouse caused using hot plate method and acetic acid is turned round
Body analgesic experiment is studied the analgesic activity at above-mentioned two position, as a result shows that C012 and the position general flavone contents of C013 two are higher, and to hot plate
The pain that method causes has good analgesic activity, and action time is more long；In C012, low dosage Dichlorodiphenyl Acetate induced pain there is preferable analgesic activity,
High dose is then without analgesic activity；C013 each dosage is not all acted on.
3rd, the effect to kansu sandwort herb regulation immune function of mice such as Li Fengwen is studied.Its tested material (kansu sandwort herb concentrate) used is dark-brown liquid
Body, is provided by Tibet snowy region biological products Co., Ltd.Experimental technique is with reference to the Ministry of Public Health《Health food is checked and assessment technique specification -2003》
Middle strengthen immunity functional check method and operational procedure are carried out.Result shows kansu sandwort herb in mouse cell immunologic function, humoral immune function, monokaryon
- macrophage function three has humidification.
4th, Wang Yanwu etc. is studied mouse immune adjustment effect Hirsutella hepiali Chen et Shen cordyceps mycelia powder.Its Hirsutella hepiali Chen et Shen filament powder used
For Lanzhou, biological medicine Co., Ltd provides.Its method reference《Health food is checked and assessment technique specification》In strengthen immunity Function detection
Method.Result shows that Hirsutella hepiali Chen et Shen filament powder has the function of strengthen immunity.
Claims (6)
1. a kind of pharmaceutical composition for treating the infection of the upper respiratory tract, it is characterised in that：The medicine is prepared by the raw material of following weight percentage
Form：Rhododendron extract：30-60%, kansu sandwort herb extract：20-50%, Hirsutella hepiali Chen et Shen powder：20-50%.
2. according to right 1, the infection of the upper respiratory tract includes common cold, viral pharyngitis, laryngitis, pharyngoconjunctivitis, bacillary
Pharyngitis-tonsillitis.
3. according to right 1, the preparation method of Rhododendron extract is that rhododendron anthopogonoide tender leaf and spray are cut into 1-3 centimetres
Segment, is extracted with 0-75% ethanol, and extracting method includes infusion process, percolation, reflux extraction, continuous circumfluence extraction method,
Solid-liquid ratio 1: 5-15, temperature is 20-65 DEG C, and extraction time 2-5 times merges extract solution, and concentration, 20-65 DEG C of temperature is obtained
Concentrate, dries and is obtained.
4. according to right 1, the preparation method of kansu sandwort herb extract is that kansu sandwort herb dries in the shade, and is crushed, and is extracted with 0-75% ethanol,
Extracting method include infusion process, percolation, reflux extraction, continuous circumfluence extraction method, solid-liquid ratio 1: 5-20,20-70 DEG C of temperature,
Extraction time 2-5 times, extraction time 1-8h, extract solution merges, concentration, and 20-70 DEG C of temperature obtains concentrate, dries and is obtained.
5. according to right 3,4, drying includes forced air drying, vacuum freeze drying, microwave drying, spray drying.
6. according to right 1, Hirsutella hepiali Chen et Shen powder is purchased from market qualified products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510794471.9A CN106692260A (en) | 2015-11-17 | 2015-11-17 | Pharmaceutical composition used for treating upper respiratory infection, and applications thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510794471.9A CN106692260A (en) | 2015-11-17 | 2015-11-17 | Pharmaceutical composition used for treating upper respiratory infection, and applications thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106692260A true CN106692260A (en) | 2017-05-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510794471.9A Pending CN106692260A (en) | 2015-11-17 | 2015-11-17 | Pharmaceutical composition used for treating upper respiratory infection, and applications thereof |
Country Status (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109270203A (en) * | 2018-10-24 | 2019-01-25 | 吉林省现代中药工程研究中心有限公司 | The construction method of neck waist recovering capsule active constituent characteristic spectrum and the quality determining method of neck waist recovering capsule |
-
2015
- 2015-11-17 CN CN201510794471.9A patent/CN106692260A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109270203A (en) * | 2018-10-24 | 2019-01-25 | 吉林省现代中药工程研究中心有限公司 | The construction method of neck waist recovering capsule active constituent characteristic spectrum and the quality determining method of neck waist recovering capsule |
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| Date | Code | Title | Description |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: SHENZHEN XINHONGMEI MEDICAL TREATMENT DEVICE CO., LTD. Document name: Notification of Publication of the Application for Invention |
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| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
Addressee: SHENZHEN XINHONGMEI MEDICAL TREATMENT DEVICE CO., LTD. Document name: Notification of before Expiration of Request of Examination as to Substance |
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| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
Addressee: SHENZHEN XINHONGMEI MEDICAL TREATMENT DEVICE CO., LTD. Document name: Notification that Application Deemed to be Withdrawn |
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| DD01 | Delivery of document by public notice | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170524 |
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| WD01 | Invention patent application deemed withdrawn after publication |