CN106692234A - Method for extracting active ingredients of angelica sinensis in Yimu biochemical mixture - Google Patents
Method for extracting active ingredients of angelica sinensis in Yimu biochemical mixture Download PDFInfo
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- CN106692234A CN106692234A CN201710123736.1A CN201710123736A CN106692234A CN 106692234 A CN106692234 A CN 106692234A CN 201710123736 A CN201710123736 A CN 201710123736A CN 106692234 A CN106692234 A CN 106692234A
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- Prior art keywords
- radix angelicae
- angelicae sinensis
- ethanol
- active ingredient
- active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0288—Applications, solvents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a method for extracting active ingredients of angelica sinensis in a Yimu biochemical mixture, wherein the problems of the prior art that different medicinal materials are mixed and extracted by the same extraction method and consequently the extraction effects of active ingredients in the medicinal materials are different and the raw materials are extremely wasted are solved. The method disclosed by the invention comprises the following steps: (1) breaking angelica sinensis into particles with particle sizes of 1.8-2.3mm; (2) soaking the particles in a container with over 99% ethanol for 6-12h, adding distilled water so that the ethanol concentration reaches 80-85%, and further soaking for 12-24h; (3) obtaining the soaking liquid, filtering, and performing hot-bath recycling of ethanol in the soaking liquid to obtain extraction liquid; and (4) washing the extraction liquid with distilled water, filtering, and drying and concentrating to obtain active ingredients of angelica sinensis. The method disclosed by the invention has the advantages of high yield, high efficiency, good effect and the like.
Description
Technical field
The present invention relates to a kind of extracting method, and in particular to the extraction side of the active ingredient of Radix Angelicae Sinensis in the female biochemistry mixture of benefit
Method.
Background technology
Beneficial female biochemistry mixture by motherwort, Radix Angelicae Sinensis, Ligusticum wallichii, peach kernel, baked ginger, Radix Glycyrrhizae (processing) above Six-element medicinal material processing and
Into.There is promoting blood circulation, antalgic, be mainly used in treatment disease that postpartum lochia can't go, abdominal pain due to blood stasis.It is greenish orange yellow
To brown color liquid.Gas is fragrant, and taste is micro- sweet.The female biochemistry mixture of the benefit is mainly used in the livestocks such as horse, ox, sheep, pig, wherein horse, Niu Yong
It is 200-300mL to measure, and sheep, pig consumption are 30-50mL.
The preparation method of the female biochemistry mixture of the benefit is disclosed in the prior art, is after various medicinal materials are mixed, using water
Pan-fried method is concentrated after extracting, in the conventional method, because the active principle of medicinal material is different, required condition during leaching
Also differ, using identical decocting temperature and leaching condition, cause the extraction effect of effective ingredient in various medicinal materials to differ, lead
Cause wastage of material.And during decocting, because temperature is too high, the property of medicine partial loss of active ingredient is easily caused, and then influence medicine
Effect.
The content of the invention
The technical problems to be solved by the invention are：It is in the prior art to different medicinal materials using identical extracting method
Mixing extraction is carried out, cause the extraction effect of effective ingredient in various medicinal materials to differ, the significant wastage in turn resulting in raw material is asked
Topic, it is therefore intended that the extracting method of the active ingredient of Radix Angelicae Sinensis in the female biochemistry mixture of the benefit for solving the above problems is provided.
The present invention is achieved through the following technical solutions：
The extracting method of the active ingredient of Radix Angelicae Sinensis in beneficial female biochemistry mixture, including：
(1) Radix Angelicae Sinensis is broken into the particle that particle diameter is 1.8~2.3mm；
(2) particle is placed in soaking container, uses concentration to be soaked for more than 99% ethanol, soak time is 6
~12h, then adding distilled water makes the concentration of ethanol reach 80%~85%, is further continued for 12~24h of immersion；
(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and ethanol obtains extract solution after reclaiming；
(4) after using distillation water washing extract solution, filtering obtains the active ingredient of Radix Angelicae Sinensis after re-dry concentration.
The invention provides a kind of method of the extracts active ingredients of the Radix Angelicae Sinensis suitable for beneficial female biochemistry mixture, by the party
The maximized extracts active ingredients by Radix Angelicae Sinensis of method energy out, and then improve extraction efficiency, and economize in raw materials cost.
In order to be able to while drug effect is ensured, effectively improve extraction efficiency and extract yield, it is preferable that the step (2)
The temperature of middle immersion is 20~25 DEG C, in immersion process and is stirred；The speed of the stirring is 6~30r/min.
In order to preferably discharge impurity, and effectively reduce concentration time, it is to avoid the drug effect of active ingredient, institute after influence concentration
The addition for stating distilled water when step (4) is middle to wash is identical with the volume of extract solution.
The present invention compared with prior art, has the following advantages and advantages：
By optimization design of the invention, make the yield of extraction higher, extraction in hgher efficiency, and can better ensure that
The drug effect of the active ingredient for extracting, effect is very notable.
Specific embodiment
To make the object, technical solutions and advantages of the present invention become more apparent, with reference to embodiment, the present invention is made
Further to describe in detail, exemplary embodiment of the invention and its explanation are only used for explaining the present invention, are not intended as to this
The restriction of invention.
Embodiment 1
The extracting method of the active ingredient of Radix Angelicae Sinensis in beneficial female biochemistry mixture, including：
(1) Radix Angelicae Sinensis is broken into the particle that particle diameter is 1.8~2.3mm.
(2) particle is placed in soaking container, uses concentration to be soaked for more than 99% ethanol, soak time is
8h, then adding distilled water makes the concentration of ethanol reach 83%, is further continued for soaking 16h；The temperature of the immersion is in this step
20~25 DEG C, and need to be stirred in immersion process, the speed of stirring is preferably 20r/min.
(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and heating bath temperature is 60 DEG C, and ethanol is obtained after reclaiming
Obtain extract solution.
(4) using being washed to extract solution with the distilled water of extract solution same volume, filter, then using low temperature drying skill
Art carries out concentrate drying to filtered fluid, and the active ingredient of Radix Angelicae Sinensis is obtained after drying.
By detection, the active ingredient of the Radix Angelicae Sinensis accounts for the 9.4% of Radix Angelicae Sinensis gross mass.
Embodiment 2
The present embodiment is the comparative examples of embodiment 1, and the solution soaked in the present embodiment is different, specific to set as follows：
(1) Radix Angelicae Sinensis is broken into the particle that particle diameter is 1.8~2.3mm.
(2) particle is placed in soaking container, uses concentration to be soaked for 85% ethanol, soak time is 24h；This
The temperature of the immersion is 20~25 DEG C in step, and need to be stirred in immersion process, and the speed of stirring is preferably 20r/
min。
(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and heating bath temperature is 60 DEG C, and ethanol is obtained after reclaiming
Obtain extract solution.
(4) using being washed to extract solution with the distilled water of extract solution same volume, filter, then using low temperature drying skill
Art carries out concentrate drying to filtered fluid, and the active ingredient of Radix Angelicae Sinensis is obtained after drying.
By detection, the active ingredient of the Radix Angelicae Sinensis accounts for the 7.3% of Radix Angelicae Sinensis gross mass.
Embodiment 3
The present embodiment is the comparative examples of embodiment 1, and the solution soaked in the present embodiment is different, specific to set as follows：
(1) Radix Angelicae Sinensis is broken into the particle that particle diameter is 1.8~2.3mm.
(2) particle is placed in soaking container, uses concentration to be soaked for 70% ethanol, soak time is 48h；This
The temperature of the immersion is 16~18 DEG C in step, and need to be stirred in immersion process, and the speed of stirring is preferably 20r/
min。
(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and heating bath temperature is 60 DEG C, and ethanol is obtained after reclaiming
Obtain extract solution.
(4) using being washed to extract solution with the distilled water of extract solution same volume, filter, then using low temperature drying skill
Art carries out concentrate drying to filtered fluid, and the active ingredient of Radix Angelicae Sinensis is obtained after drying.
By detection, the active ingredient of the Radix Angelicae Sinensis accounts for the 7.8% of Radix Angelicae Sinensis gross mass.
Embodiment 4
The present embodiment is the comparative examples of embodiment 1, and the solution soaked in the present embodiment is different, specific to set as follows：
(1) Radix Angelicae Sinensis is broken into the particle that particle diameter is 1.8~2.3mm.
(2) particle is placed in soaking container, uses concentration to be soaked for more than 99% ethanol, soak time is
6h, then adding distilled water makes the concentration of ethanol reach 70%, is further continued for soaking 18h；The temperature of the immersion is in this step
16~18 DEG C, and need to be stirred in immersion process, the speed of stirring is preferably 20r/min.
(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and heating bath temperature is 60 DEG C, and ethanol is obtained after reclaiming
Obtain extract solution.
(4) using being washed to extract solution with the distilled water of extract solution same volume, filter, then using low temperature drying skill
Art carries out concentrate drying to filtered fluid, and the active ingredient of Radix Angelicae Sinensis is obtained after drying.
By detection, the active ingredient of the Radix Angelicae Sinensis accounts for the 8.1% of Radix Angelicae Sinensis gross mass.
Above-described specific embodiment, has been carried out further to the purpose of the present invention, technical scheme and beneficial effect
Describe in detail, should be understood that and the foregoing is only specific embodiment of the invention, be not intended to limit the present invention
Protection domain, all any modification, equivalent substitution and improvements within the spirit and principles in the present invention, done etc. all should include
Within protection scope of the present invention.
Claims (4)
1. in the female biochemistry mixture of benefit the active ingredient of Radix Angelicae Sinensis extracting method, it is characterised in that including：
(1) Radix Angelicae Sinensis is broken into the particle that particle diameter is 1.8~2.3mm；
(2) particle is placed in soaking container, uses concentration to be soaked for more than 99% ethanol, soak time be 6~
12h, then adding distilled water makes the concentration of ethanol reach 80%~85%, is further continued for 12~24h of immersion；
(3) soak, filtering are obtained, the ethanol in soak is reclaimed in heating bath, and ethanol obtains extract solution after reclaiming；
(4) after using distillation water washing extract solution, filtering obtains the active ingredient of Radix Angelicae Sinensis after re-dry concentration.
2. in the female biochemistry mixture of benefit according to claim 1 the active ingredient of Radix Angelicae Sinensis extracting method, it is characterised in that institute
The temperature of immersion in step (2) is stated for 20~25 DEG C, in immersion process and is stirred.
3. in the female biochemistry mixture of benefit according to claim 2 the active ingredient of Radix Angelicae Sinensis extracting method, it is characterised in that institute
The speed for stating stirring is 6~30r/min.
4. in the female biochemistry mixture of benefit according to claim 1 the active ingredient of Radix Angelicae Sinensis extracting method, it is characterised in that institute
The addition for stating distilled water when step (4) is middle to wash is identical with the volume of extract solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710123736.1A CN106692234A (en) | 2017-03-03 | 2017-03-03 | Method for extracting active ingredients of angelica sinensis in Yimu biochemical mixture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710123736.1A CN106692234A (en) | 2017-03-03 | 2017-03-03 | Method for extracting active ingredients of angelica sinensis in Yimu biochemical mixture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106692234A true CN106692234A (en) | 2017-05-24 |
Family
ID=58912154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710123736.1A Pending CN106692234A (en) | 2017-03-03 | 2017-03-03 | Method for extracting active ingredients of angelica sinensis in Yimu biochemical mixture |
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| CN (1) | CN106692234A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9716426D0 (en) * | 1997-07-31 | 1997-10-08 | Litton International Limited | A process for producing a herbal extract composition |
| CN102381962A (en) * | 2011-10-19 | 2012-03-21 | 兰州理工大学 | Extraction method of effective components of Chinese angelica |
| CN105079059A (en) * | 2015-09-07 | 2015-11-25 | 宜诺(天津)医药工程有限公司 | Angelica sinensis extract and extraction method |
-
2017
- 2017-03-03 CN CN201710123736.1A patent/CN106692234A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9716426D0 (en) * | 1997-07-31 | 1997-10-08 | Litton International Limited | A process for producing a herbal extract composition |
| CN102381962A (en) * | 2011-10-19 | 2012-03-21 | 兰州理工大学 | Extraction method of effective components of Chinese angelica |
| CN105079059A (en) * | 2015-09-07 | 2015-11-25 | 宜诺(天津)医药工程有限公司 | Angelica sinensis extract and extraction method |
Non-Patent Citations (1)
| Title |
|---|
| 蹇红玉等: "当归渗漉法提取工艺的研究", 《湖南中医杂志》 * |
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Application publication date: 20170524 |
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