CN106668100A - Application of eight-component medicine in preparing drug for treating meningitis - Google Patents
Application of eight-component medicine in preparing drug for treating meningitis Download PDFInfo
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Abstract
The invention relates to the field of medicine preparations, and discloses application of an eight-component medicine in preparing a drug for treating meningitis. According to the eight-component medicine, a new application field different from an original curative effect is developed on the application basis of an existing eight-component medicine and a preparation thereof, and the effects and the synergistic effect of medicine components of calculus bovis, snake gall, cornu saigae tataricae, radix notoginseng, pearl, moschus and the like can be reflected; a clinical test shows that the effective rate of treatment is high, and a new traditional Chinese medicine treatment path is developed for treating the meningitis.
Description
Technical field
The present invention relates to the application of field of pharmaceutical preparations, particularly pill of Eight Treasures in treatment meningitiss medicine is prepared.
Background technology
Meningitiss mean that Leptomeningeal diffusivity inflammation is sexually revised.By antibacterial, virus, funguses, spirillum, protozoon, Garrick
The various biological virulence factors such as secondary body, tumor and leukemia invade pia mater encephali and membrane of spinal cord causes.Bacterial meningitises are one
The disease for planting especially severe need to be treated in time, if treatment is not in time, in death in a few hours or may cause permanent
Brain injury.Though viral meningitises can recover completely than more serious but most people, minority leaves sequela.Meningitiss can involve
Cerebral dura mater, arachnoidea and pia mater encephali.Skull infection is secondary to pachymeningitis more.Since antibiotic extensively application, cerebral dura mater
Scorching sickness rate is greatly reduced.Piitiss are then rather common, including arachnoidea and pia mater encephali inflammation.Therefore, current meningitiss
For actually referring to piitiss.The meningitiss overwhelming majority is caused by pathogen, the popularity caused by meningococcus
Meningitiss are wherein topmost types；Minority is caused by zest chemical drugss.
The traditional Chinese medical science then thinks that the disease hinders yin-Yang, crystal, QI and blood by the disease for suffering from consumptive disease long, consumption.Evil poison multiple abscess meridians, blood
Arteries and veins, takes advantage of brain QI-insufficiency, and battalion defends fall, invades brains, pents up Muyuan adipose membrane, the sick poison of the poly- blood of heap soil or fertilizer over and around the roots expectorant form brain consumptive disease convulsion it.It is clinical
It is presented with heating, nausea and vomiting, headache, drowsiness or dysphoria etc..
The content of the invention
It is an object of the invention to provide application of the pill of Eight Treasures in treatment meningitiss medicine is prepared, is treated using pill of Eight Treasures
Primary disease can avoid the intake of long-term antibiotic, Small side effects, dialectical individualized treatment, while the spy such as conditioning human body yang blood and qi balance
Point, has the advantage that other Western medicine are not replaced.
To realize above-mentioned technical purpose, above-mentioned technique effect is reached, the invention discloses pill of Eight Treasures is preparing treatment meninges
Application in scorching medicine.
Wherein, pill of Eight Treasures selectively adds customary adjuvant, and routinely technique makes clinically acceptable preparation, preparation bag
Include lozenge, capsule, tablet, granule, pill, powder.
Pill of Eight Treasures day 1~1.6g of dose.
The invention has the advantages that：
The present invention by the reasonably optimizing of formula, using pill of Eight Treasures powder, wherein, pill of Eight Treasures by Calculus Boviss, Fel Serpentis, Cornu Saigae Tataricae, Radix Notoginseng,
The medicines such as Margarita, Moschus are formulated.Calculus Boviss are our principal agents, play the role of heat-clearing and toxic substances removing, eliminating phlegm, have one's ideas straightened out, function of gallbladder promoting, have research
Confirm that Calculus Boviss are improved can also the phagocytic function of mouse macrophage, mouse humoral immune ability can be strengthened;Fel Serpentis and antelope
Cornu Caprae seu Oviss are our ministerial drugs, and Fel Serpentis have functions that refrigerant improving eyesight, expelling wind and removing dampness, can also adjust human endocrine system, nerveous system
System and immune system, have the effect of to delay body aging;Cornu Saigae Tataricae plays the role of relieving spasm by subduing liver-wind, cool blood detumescence;Radix Notoginseng and Margarita
It is our adjuvant drug, the effect with pain relieving, blood circulation promoting and blood stasis dispelling has research to confirm that Radix Notoginseng can also increase the activity of macrophage, carries
The high lethality to tumor cell;Margarita has preferable radioprotective, antitumor and immunologic enhancement;Moschus and Cornu Saigae Tataricae can
Promote effect of the effective ingredient by blood brain barrier in Chinese medicine.
The present invention develops the new applications different from script curative effect on the application foundation of existing pill of Eight Treasures and its preparation
Field, several main components of the above play its respective effect and synergism, and by clinical trial, its treated effect is high,
A kind of new treatment by Chinese herbs method is opened to treat meningitiss.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, with reference to embodiments, to the present invention
It is further elaborated.
Embodiment 1
Take commercially available Hylotelephium erythrostictum (Miq.) H.Ohba capsule（Chinese medicines quasi-word Z10940006, Xiamen Chinese Medicine Co., Ltd's production）Content fill capsule,
Per 0.3g containing pill of Eight Treasures, for preparing in treatment meningitiss medicine, when patient takes, 2 times a day, 2 every time.
Embodiment 2
Take commercially available pill of Eight Treasures lozenge（Chinese medicines quasi-word Z10940005, Xiamen Chinese Medicine Co., Ltd's production）Crush, add conventional auxiliary
Material makes tablet, contains pill of Eight Treasures 0.5g in every tablet preparation, for preparing in treatment meningitiss medicine, when patient takes, daily 2
Secondary, 1 tablet once.
Embodiment 3
Take commercially available pill of Eight Treasures lozenge（Chinese medicines quasi-word Z10940005, Xiamen Chinese Medicine Co., Ltd's production）Crush, add conventional auxiliary
Material makes granule, contains pill of Eight Treasures 0.5g in every bag of granule, for preparing in treatment meningitiss medicine, when patient takes,
2 times a day, 1 bag every time.
Embodiment 4
Take commercially available pill of Eight Treasures lozenge（Chinese medicines quasi-word Z10940005, Xiamen Chinese Medicine Co., Ltd's production）Crush, add conventional auxiliary
Material makes pill, contains pill of Eight Treasures 0.5g in every pill, for preparing in treatment meningitiss medicine, when patient takes, daily 2
It is secondary, 1 every time.
Embodiment 5
Take commercially available pill of Eight Treasures lozenge（Chinese medicines quasi-word Z10940005, Xiamen Chinese Medicine Co., Ltd's production）Crush, add conventional auxiliary
Material makes powder, contains pill of Eight Treasures 0.8g in every bag of powder, for preparing in treatment meningitiss medicine, when patient takes, daily 2
It is secondary, 1 bag every time.
Embodiment 6
Test method and purpose：The present embodiment does checking explanation for 100 with somewhere hospital Patients with Virus Meningitis to the present invention,
Patient is divided into into traditional treatment group and experimental therapy group, traditional treatment group patient 20, traditional treatment group is taken compound recipe pyrrole and draws west
Smooth brain protein hydrolysate tablet, 3 times a day, one time 3；Experimental therapy group patient 80,4 groups of Xia Fen take embodiment 1, implement
Hylotelephium erythrostictum (Miq.) H.Ohba pellet preparation prepared by example 2, embodiment 3 and embodiment 5.
Experimental effect criterion:
(1) it is effective:Jing treats 3 days body temperature normally, and neurological symptom is clearly better；
(2) effectively:Jing treats 3 days body temperature normally, and neurological symptom has taken a turn for the better；
(3) it is invalid:Jing treats 3 days body temperature and does not still drop, and neurological symptom does not mitigate or even increases.
Experimental result：
1 traditional treatment group of table and experimental therapy group randomized controlled treatment result
The present invention can be seen that by therapeutic outcome in table 1 there is to viral meningitises significantly treatment and improvement, experiment
In each embodiment for the treatment of group, pill of Eight Treasures weight is respectively 1.2g/ days, 1g/ days, 1g/ days and 1.6g/ days, through different use
After amount, the taking of different dosage form, for the uncomfortable phenomenon produced by viral meningitises has significantly improvement, effectively with it is effective
Rate sum is more than 90%, the no significant difference compared with treatment group, with obvious therapeutic effect.
Embodiment 7
Experiment purpose and method：The present embodiment is with somewhere hospital Patients with Virus Meningitis 200 in pill of Eight Treasures in the present invention
Application of the medicine in meningitiss treatment is mitigated in side effect carries out checking explanation, and patient is divided into traditional treatment group and experimental therapy
Group, traditional treatment group patient 40 give acyclovir expectant treatment；Experimental therapy group patient 120,4 groups of Xia Fen take Ah former times
Treatment by Chinese herbs, wherein treatment by Chinese herbs is given to take embodiment 1 respectively, implement by the antibiotic usage stage on the basis of the Wei expectant treatment of Lip river
Hylotelephium erythrostictum (Miq.) H.Ohba pellet preparation prepared by example 2, embodiment 3 and embodiment 5, observation is contrasted before treating, after treatment January, the 2nd month future trouble for the treatment of
A situation arises for the blood biochemical test rating of person, routine blood indexes and side effect.
Experimental result：
2 two groups of randomized controlled treatment result biochemical indicators of table and routine blood indexes compare
3 two groups of randomized controlled treatment side effect profiles of table compare
| Group | Number | Drug reaction | Phlebitis | Renal damage | Hepatic injury | Hemopoietic function is damaged |
| Traditional treatment group | 40 | 21 | 18 | 14 | 11 | 6 |
| Experimental therapy group（Embodiment 1） | 40 | 14 | 8 | 6 | 4 | 3 |
| Experimental therapy group（Embodiment 2） | 40 | 15 | 5 | 5 | 4 | 2 |
| Experimental therapy group（Embodiment 3） | 40 | 14 | 5 | 4 | 4 | 3 |
| Experimental therapy group（Embodiment 5） | 40 | 14 | 5 | 6 | 4 | 2 |
By Experimental comparison and Continuous Observation it is found that under the contrast of traditional treatment group and experimental therapy group it is found that
Experimental therapy group has to meningitiss common adverse effects such as drug reaction, phlebitis, renal damage, hepatic injury, hemopoietic function infringements
Obvious inhibitory action, corresponding biochemical indicator improve significantly compared with traditional treatment group, and these results all illustrate rationally clothes
Antibiotic side effect can be mitigated, antibiotic increment is assisted, be there is significant curative effect to alleviating the state of an illness with Chinese medicine.
Embodiment 8
Experiment purpose and method：The present embodiment is with somewhere hospital purulent meningitiss young children 78 to pill of Eight Treasures in the present invention
At " inducting the medicines into affected channel ", lifting antibacterials penetrate effect carries out checking explanation to Chinese medicine, and patient is divided into traditional treatment group and experiment
Treatment group, traditional treatment group patient 26 give antibacterial expectant treatment；Experimental therapy group patient 52,2 group's antibacterials of Xia Fen guard
Give treatment by Chinese herbs on the basis for the treatment of, Hylotelephium erythrostictum (Miq.) H.Ohba pellet preparation prepared by embodiment 1, embodiment 3, inspection are taken in wherein treatment by Chinese herbs respectively
The cerebrospinal fluid midbrain leukocyte count and cerebrospinal fluid/blood of patient after surveying contrast treatment the 1st week, after treating the 2nd week, after treating the 3rd week
Drug level ratio.
Experimental result：
The clinical manifestation symptom of 4 infant of table
| Symptom | Heating | Vomiting | Twitch | Disturbance of consciousness | Bregma is nervous |
| Number of cases | 37 | 22 | 21 | 13 | 16 |
| Accounting | 47.4% | 28.2% | 26.9% | 16.7% | 20.5% |
Note：Accounting contains same young children's various clinical symptoms symptom in calculating.
5 different treatment time infant cerebrospinal fluid midbrain leukocyte counts of table and cerebrospinal fluid/Blood drug concentration ratio
When the present embodiment is admitted to hospital in passing through, child is respectively provided with obvious clinical manifestation, possess heating, vomiting, tic, disturbance of consciousness,
The clinical manifestations such as bregma anxiety, the meningeal irritation sign positive, cerebrospinal fluid（Routine biochemistry result leukocyte increases up to hundreds of to several
Ten thousand/L, wherein based on multinuclear leucocyte, the suppuration of glucose ＜ 2mmol/L, Protein G T.GT.GT 1g/L is sexually revised and/or CSF smears,
Antibacterial is found in culture.Screen pathogenic bacterium to be controlled for streptococcus agalactiae, escherichia coli and listerisa monocytogenes in mjme
Treat, treated using penicillins joint cefotaxime.
As can be seen from Table 5, with the change for the treatment of time, the leukocyte count in cerebrospinal fluid has significantly reduction,
Treatment 3 weeks or so, leukocyte count is already close to Normal Infants 0-20*106The leukocyte count of/L, reaches discharge and requires.Exist simultaneously
In the therapeutic process of purulent meningitiss, Hylotelephium erythrostictum (Miq.) H.Ohba sublimed preparation is taken（Child's dose halves）It is found that Hylotelephium erythrostictum (Miq.) H.Ohba sublimed preparation itself tool
The antibacterial that plays the role of, antiinflammatory can effectively assist antibacterials to carry out bacteriostatic treatments, and pass through cerebrospinal fluid/Blood drug concentration
The Data Comparison of ratio it is found that Hylotelephium erythrostictum (Miq.) H.Ohba sublimed preparation is significantly improved on antibacterials penetrance is improved, in Hylotelephium erythrostictum (Miq.) H.Ohba sublimed preparation
The penetration capacity of medicine under auxiliary, can be effectively improved, plays a part of " inducting the medicines into affected channel ", be that the use for reducing antibiotic is carried
Go out new Chinese medicine solution.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
Any those familiar with the art the invention discloses technical scope in, the change or replacement that can be readily occurred in,
Should all be included within the scope of the present invention.
Claims (7)
1. application of the pill of Eight Treasures in treatment meningitiss medicine is prepared.
2. application of the pill of Eight Treasures according to claim 1 in treatment meningitiss medicine is prepared, it is characterised in that：Described eight
BAODAN selectively adds customary adjuvant, and routinely technique makes clinically acceptable preparation, and described preparation includes lozenge, glue
Wafer, tablet, granule, pill, powder.
3. application of the pill of Eight Treasures as claimed in claim 2 in treatment meningitiss medicine is prepared, it is characterised in that described
Pill of Eight Treasures day 1~1.6g of dose.
4. application of the pill of Eight Treasures as claimed in claim 3 in treatment meningitiss medicine is prepared, it is characterised in that described eight
BAODAN is combined with antiviral drugs in treatment viral meningitises.
5. application of the pill of Eight Treasures as claimed in claim 3 in treatment meningitiss medicine is prepared, it is characterised in that described eight
BAODAN treatment purulent meningitiss in Penicillin antibiotics, third generation cephalosporin or vancomycin in one kind or several
Plant combination.
6. application of the pill of Eight Treasures as claimed in claim 3 in treatment meningitiss medicine is prepared, it is characterised in that described eight
BAODAN treatment tuberculous meningitis in a line antituberculotics or two wires antituberculotics in one or more combination.
7. application of the pill of Eight Treasures as claimed in claim 3 in treatment meningitiss medicine is prepared, it is characterised in that described eight
BAODAN is used in combination with amphotericin, flucytosine in acute stages treated in crypotococcal, in consolidation and chronic phase
Use with fluconazole.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403765A (en) * | 2018-05-24 | 2018-08-17 | 唐水金 | Pill of Eight Treasures treats the purposes of gingivitis and its pharmaceutical composition of pill of Eight Treasures |
| CN110420226A (en) * | 2019-09-18 | 2019-11-08 | 厦门中药厂有限公司 | Pill of Eight Treasures is preparing the purposes in the drug for preventing or treating disease relevant to IL-6 inflammatory factor storm |
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| CN101579506A (en) * | 2008-05-14 | 2009-11-18 | 北京和润创新医药科技发展有限公司 | Bezoar chest functioning preparation and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403765A (en) * | 2018-05-24 | 2018-08-17 | 唐水金 | Pill of Eight Treasures treats the purposes of gingivitis and its pharmaceutical composition of pill of Eight Treasures |
| CN110420226A (en) * | 2019-09-18 | 2019-11-08 | 厦门中药厂有限公司 | Pill of Eight Treasures is preparing the purposes in the drug for preventing or treating disease relevant to IL-6 inflammatory factor storm |
| CN110420226B (en) * | 2019-09-18 | 2021-11-09 | 厦门中药厂有限公司 | Application of Babaodan in preparation of medicine for preventing or treating diseases related to IL-6 inflammatory factor storm |
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