CN106667973A - Composition for preventing haze damage and preparation method and spray of composition - Google Patents
Composition for preventing haze damage and preparation method and spray of composition Download PDFInfo
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- CN106667973A CN106667973A CN201710054164.6A CN201710054164A CN106667973A CN 106667973 A CN106667973 A CN 106667973A CN 201710054164 A CN201710054164 A CN 201710054164A CN 106667973 A CN106667973 A CN 106667973A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- General Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
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- Otolaryngology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to a composition for preventing haze damage. The composition is prepared from the following materials: 0.0788-0.1182mg/ml of ferulic acid, 0.08-0.12mg/ml of resveratrol, 0.075-0.125mg/ml of astragalus polysaccharide, 0.078-0.12mg/ml of salvianic acid B, 0.00008-0.00012mg/ml of absolute ethyl alcohol, 0.15-0.25mg/ml of anthocyanin, and 0.2-0.3mg/ml of chlorophyll. The invention further relates to a composition for preventing haze damage, a preparation method thereof, and an atomized spray prepared by use of the composition. By use of the composition and the atomized spray, the damage of the haze to the live tissue can be effectively prevented, and the damaged tissue can be repaired.
Description
Technical field
The present invention relates to sanitation and health-care field, more specifically it relates to a kind of compositionss damaged for haze, its preparation
Method, and the atomization spray prepared with the compositionss.
Background technology
With the development in epoch, people increasingly pay close attention to impact of the air quality to living.Haze is a kind of atmospheric pollution
State, is the general statement to various suspended particulate substance content overproofs in air, sulfur dioxide, nitrogen oxides and inhalable
Grain thing is haze main constituents.In general, mist and haze are the presence of certain difference on concrete composition.Containing various in mist
Harmful fine grained, noxious substance includes acid, alkali, salt, amine, phenol etc., and dust, pollen, demodicid mite up to kind more than 20
Worm, influenza virus, tubercule bacillus, streptococcus pneumoniae etc., its content is tens times of normal atmospheric water droplet.Compared with mist, haze is to people
Healthy harm it is bigger.Particulate of the mainly diameter less than 10 microns being wherein harmful to health, such as mineral
Grain thing, sea salt, sulfate, nitrate, Organic aerosol particle, fuel and automobile exhaust gas etc., it can be directly entered and stick to
In human respiratory tract and alveolar.Especially submicron particle can be deposited in upper and lower respiratory tract and alveolar, cause acute nose
The diseases such as scorching and acute bronchitiss.For bronchial asthma, chronic bronchitiss, obstructive emphysema and chronic obstructive pulmonary
The chronic respiratory disease patients such as disease, haze can make state of an illness acute attack or acute exacerbation.If being chronically at this ring
Border is it is also possible to induction pulmonary carcinoma.
Impact of the haze to human body cardiovascular and cerebrovascular disease is also very serious, can hinder normal blood circulation, causes cardiovascular
Disease, hypertension, coronary heart disease, cerebral hemorrhage, may induce angina pectoriss, myocardial infarction, heart failure etc., chronic bronchitiss occur
Pulmonary heart disease etc..
There are enough scientific research results to prove, Fine Particles can adsorb in a large number carcinogen and genotoxicity mutation
Material, gives people body health care belt and carrys out very important negative effect, including improves mortality rate, make chronic disease aggravation, make respiratory system
And cardiac system disease progression, change pulmonary function and structure, affect reproductive performance, change immune structure of human body etc..
Indoor pollution causes dirt mainly due to various volatile organic matters present in room air to indoor environment
The phenomenon of dye.The main source of indoor air pollutants has the following aspects：Building and house decorative material, outdoor pollution
Thing, combustion product, smoking, outdoor haze weather affect and people activity itself.The pollution of wherein house decorative material and furniture is
The main aspect of room air pollution is caused at present.Additionally, smoking is also that harm widely causes room air including second hand smoking
The major reason of pollution.Have research to point out, even second hand smoking, still containing tar, ammonia, nicotine, suspended particulates,
PM2.5, polonium -210 etc. are more than 4000 kinds of harmful chemicals and tens of kinds of carcinogen.
Room air pollution endangers and larger mainly has radon, formaldehyde, benzene, ammonia and ester, trichloro ethylene etc..US Experts are examined
Survey and find, there is more than 500 kinds of volatile organic matter in air indoors, wherein carcinogen has kind more than 20, Causative viruss more than 200
Kind.A large amount of startling facts confirm that room air pollution becomes " the stealthy killer " of harm human health, is also full generation
The problem that various countries of boundary pay close attention to jointly.World Health Organization (WHO) is also by room air pollution and hypertension, hypercholesterolemia disease and fertilizer
The common columns such as fat disease are threatened greatly for the 10 of human health.According to statistics, the people of the nearly half in the whole world is indoor in room air pollution
Environmental pollution has caused 35.7% respiratory tract disease, 22% chronic lung disease and 15% tracheitiies, bronchitis and lung
Cancer.
Harmful substance (mainly superoxides matter) the Jing respiratory tracts suction pulmonary that above-mentioned environmental pollution brings, can be in lung
Portion forms inflammatory reaction, and in turn results in histiocytic infringement, and long term accumulation trigger cell is mutated and tumor occurs (such as lung
Cancer), cell death and there is fibroblast proliferation and cause pulmonary fibrosiss even pneumosclerosis.Hazardous substance it is transpulmonary enter blood can cause blood
Pipe is damaged, and and then formation thrombosis cause thrombotic disease.
Accordingly, it would be desirable to a kind of medicine spray be used to preventing or treat some diseases that haze or indoor harmful substance cause or
Symptom.
The content of the invention
To solve problem above, the invention provides a kind of compositionss damaged for haze, comprising 0.0788-
The ferulic acid of 0.1182mg/ml, the resveratrol of 0.08-0.12mg/ml, 0.075-0.125mg/ml astragalus polysaccharidess, 0.078-
The lithospermic acid B of 0.12mg/ml, the dehydrated alcohol of 0.00008-0.00012mg/ml, the anthocyanidin of 0.15-0.25mg/ml, 0.2-
The chlorophyll of 0.3mg/ml.
Preferably, the solvent of the compositionss is water or normal saline.
The invention also discloses the preparation method of above-mentioned composition, comprises the following steps：
S1：By ferulic acid, resveratrol, astragalus polysaccharidess, lithospermic acid B, dehydrated alcohol, anthocyanidin, chlorophyll by corresponding
Amount is added in solvent, and heated and stirred is to being completely dissolved；
S2：Constant volume, that is, obtain the compositionss.
Preferably, the solvent is water or normal saline.
The compositionss can be atomized to improve ambient air quality and have anti-fog haze and indoor environment dirty by humidifier
The damaging action that dye is caused, natural extract can directly from oral cavity after atomization, and air flue reaches alveolar, alleviates pulmonary because environmental pollution is made
Into damage, in addition to room humidifier, can also be used by modes such as personal suction nebulizer, vehicle-mounted atomizing humidifiers.
The invention also discloses another kind of preparation method of above-mentioned composition, comprises the following steps：
S1’：By ferulic acid, resveratrol, astragalus polysaccharidess, lithospermic acid B, dehydrated alcohol, anthocyanidin, chlorophyll by corresponding
5-10 times of amount is added in solvent, and heated and stirred is to being completely dissolved；
S2’：Constant volume is prepared into high concentration storing liquid；
S3’：Respective concentration is diluted to using the high concentration storing liquid is front taken, that is, obtains the compositionss.
The invention also discloses a kind of atomization spray damaged for haze, it is made up of above-mentioned composition.
Material used has the beneficial effect that：
1st, ferulic acid：Anti-platelet aggregation and thrombosis；Antiinflammatory；Scavenging activated oxygen, nitrite, peroxynitrite；
Strengthen immunologic function；Antibacterial, antiviral；Antitumor；Mutation etc..
2nd, resveratrol：Defying age, antitumor, preventing and treating cardiovascular and cerebrovascular disease, antibacterial, antioxidation, immunomodulating resist breathes heavily
Biological activity.
3rd, astragalus polysaccharidess：Delay with enhancing function of immune system, antitumor, liver protection, blood sugar lowering, antiviral, antioxidation
Aging etc. is acted on.
4th, Radix Salviae Miltiorrhizae acid：The effect of stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness that clears away heart-fire with resist myocardial ischemia, anti-cerebral ischemia, anti-blood
Bolt, improve microcirculation, the reparation of promotion organization and regeneration, and the multiple pharmacological effect such as sedation and analgesia.
5th, ethanol：After ethanol and methanol competition alcoholdehydrogenase, methanol and ethanol are entered in vivo, under alcoholdehydrogenase effect
Become formaldehyde, acetaldehyde, formaldehyde and acetaldehyde become formic acid and acetic acid under aldehyde dehydrogenase effect.Acetic acid can be by intracellular oxidase
The further metabolic breakdown of system, ultimately becomes carbon dioxide and water, and provides energy for human body.And formic acid cannot continue by generation
Thank, can accumulate, cause poisoning.Add ethanol to suppress the oxidation of methanol, reduce the yield of formaldehyde formic acid.
6th, anthocyanidin：Potent antioxidants, are hydroxyl donors, while be also a kind of free radical scavenger, it can and albumen
Matter is combined and prevents peroxidating.Normal cell linkages, the stable of blood vessel, enhancement capillary vessel circulation, raising blood capillary can be maintained
With the flowing of vein.
7th, chlorophyll：Bactericidal antiphlogistic, rich in ferrum element, can hemopoietic, provide vitamin, removing toxic substances, releasing drug disposition residue,
Prophylaxis of cancer, maintains the activity of enzyme so as to given play to extremely strong antioxidation, resists free radical, slow down aging.Suppress metabolism
During produce sulfide.
By using combination of the above thing or spray, damage of the haze to lung tissue and blood vessel can be effectively prevented, and to damaging
Injured tissue is repaired.
Specific embodiment
The principle and feature of the present invention are described below in conjunction with example, example is served only for explaining the present invention, and
It is non-for limiting the scope of the present invention.
Embodiment 1
Take the ferulic acid 0.08g of concentration 98.5%, the water-soluble resveratrol 0.8g of concentration 10%, the Radix Astragali of concentration 50%
Polysaccharide 0.15g, 60% lithospermic acid B 0.13g, 99% dehydrated alcohol 0.08ml, anthocyanidin 0.15g, chlorophyll 0.20g, add pure
Water, heated and stirred is settled to 1000ml to being completely dissolved, and is prepared into the atomization spray of low concentration.
The atomization spray for preparing is added in humidifier water tank, switch is opened and is adjusted to middling speed humidification atomization, about 2-4 hours
Can be using finishing, time length slightly difference because humidifier brand and model is different.
Embodiment 2
The ferulic acid 0.1g of concentration 98.5% is taken, the water-soluble resveratrol 1g of concentration 10%, the Radix Astragali of concentration 50% is more
Sugared 0.2g, 60% lithospermic acid B 0.17g, 99% dehydrated alcohol 0.1ml, anthocyanidin 0.2g, chlorophyll 0.25g, add pure water, plus
Thermal agitation is settled to 1000ml to being completely dissolved, and is prepared into the atomization spray of low concentration.
The atomization spray for preparing is added in humidifier water tank, switch is opened and is adjusted to middling speed humidification atomization, about 2-4 hours
Can be using finishing, time length slightly difference because humidifier brand and model is different.
Embodiment 3
Take the ferulic acid 0.12g of concentration 98.5%, the water-soluble resveratrol 1.2g of concentration 10%, the Radix Astragali of concentration 50%
Polysaccharide 0.25g, 60% lithospermic acid B 0.2g, 99% dehydrated alcohol 0.12ml, anthocyanidin 0.25g, chlorophyll 0.3g, add pure
Water, heated and stirred is settled to 1000ml to being completely dissolved, and is prepared into the atomization spray of low concentration.
The atomization spray for preparing is added in humidifier water tank, switch is opened and is adjusted to middling speed humidification atomization, about 2-4 hours
Can be using finishing, time length slightly difference because humidifier brand and model is different.
Embodiment 4
Take the ferulic acid 1g of concentration 98.5%, the water-soluble resveratrol 10g of concentration 10%, the astragalus polysaccharidess of concentration 50%
2g, 60% lithospermic acid B 1.7g, 99% dehydrated alcohol 1ml, anthocyanidin 2g, chlorophyll 2.5g, add pure water, and heated and stirred is to complete
CL, is settled to 1000ml, is prepared into the atomization spray of high concentration.High concentration atomization spray can dilute and use, convenient storage.
The high concentration for preparing is atomized into spray 100ml, in adding humidifier water tank, 900ml pure water is added, is mixed,
Open switch and be adjusted to middling speed humidification atomization, about 2-4 hours can be using finishing, and time length is omited because humidifier brand and model is different
It is variant.
By using the spray in above example, damage of the haze to lung tissue and blood vessel can be effectively prevented, and to
Injury tissue is repaired.
The foregoing is only presently preferred embodiments of the present invention, not to limit the present invention, all spirit in the present invention and
Within principle, any modification, equivalent substitution and improvements made etc. should be included within the scope of the present invention.
Claims (6)
1. it is a kind of for haze damage compositionss, it is characterised in that the ferulic acid comprising 0.0788-0.1182mg/ml,
The resveratrol of 0.08-0.12mg/ml, 0.075-0.125mg/ml astragalus polysaccharidess, the lithospermic acid B of 0.078-0.12mg/ml,
The dehydrated alcohol of 0.00008-0.00012mg/ml, the anthocyanidin of 0.15-0.25mg/ml, the chlorophyll of 0.2-0.3mg/ml.
2. compositionss according to claim 1, it is characterised in that the solvent of the compositionss is water or normal saline.
3. a kind of preparation method of compositionss as claimed in claim 1 or 2, it is characterised in that comprise the following steps：
S1：Ferulic acid, resveratrol, astragalus polysaccharidess, lithospermic acid B, dehydrated alcohol, anthocyanidin, chlorophyll are added by corresponding amount
In entering solvent, heated and stirred is to being completely dissolved；
S2：Constant volume, that is, obtain the compositionss.
4. preparation method according to claim 3, it is characterised in that the solvent is water or normal saline.
5. a kind of preparation method of compositionss as claimed in claim 1 or 2, it is characterised in that comprise the following steps：
S1’：By ferulic acid, resveratrol, astragalus polysaccharidess, lithospermic acid B, dehydrated alcohol, anthocyanidin, chlorophyll by corresponding amount
5-10 times adds in solvent, and heated and stirred is to being completely dissolved；
S2’：Constant volume is prepared into high concentration storing liquid；
S3’：Respective concentration is diluted to using the high concentration storing liquid is front taken, that is, obtains the compositionss.
6. it is a kind of for haze damage atomization spray, it is characterised in that the compositionss by described in claim 1 or 2 are made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710054164.6A CN106667973A (en) | 2017-01-22 | 2017-01-22 | Composition for preventing haze damage and preparation method and spray of composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710054164.6A CN106667973A (en) | 2017-01-22 | 2017-01-22 | Composition for preventing haze damage and preparation method and spray of composition |
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| CN106667973A true CN106667973A (en) | 2017-05-17 |
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| CN201710054164.6A Pending CN106667973A (en) | 2017-01-22 | 2017-01-22 | Composition for preventing haze damage and preparation method and spray of composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110960603A (en) * | 2020-01-06 | 2020-04-07 | 泰州欣康生物技术有限公司 | Anti-haze damage composition, preparation method and use method thereof |
| CN111265496A (en) * | 2018-12-04 | 2020-06-12 | 高雄医学大学 | Anti-haze compositions |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2201964A2 (en) * | 2002-03-01 | 2010-06-30 | CHIESI FARMACEUTICI S.p.A. | Formoterol superfine formulation |
| CN104095182A (en) * | 2014-06-16 | 2014-10-15 | 李卫平 | Food with protection effect on lung injury caused by fog and haze |
| CN105747047A (en) * | 2016-03-22 | 2016-07-13 | 陈波 | Anti-haze drink capable of reducing haze-induced lung injuries and preparation method of anti-haze drink |
-
2017
- 2017-01-22 CN CN201710054164.6A patent/CN106667973A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2201964A2 (en) * | 2002-03-01 | 2010-06-30 | CHIESI FARMACEUTICI S.p.A. | Formoterol superfine formulation |
| CN104095182A (en) * | 2014-06-16 | 2014-10-15 | 李卫平 | Food with protection effect on lung injury caused by fog and haze |
| CN105747047A (en) * | 2016-03-22 | 2016-07-13 | 陈波 | Anti-haze drink capable of reducing haze-induced lung injuries and preparation method of anti-haze drink |
Non-Patent Citations (2)
| Title |
|---|
| 任永献，等: "《食物中毒的诊断和处理》", 31 March 2007, 中国科学技术出版社 * |
| 周艳丽，等: "阿魏酸拮抗大气PM2.5对大鼠肺的损伤作用", 《食品科学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111265496A (en) * | 2018-12-04 | 2020-06-12 | 高雄医学大学 | Anti-haze compositions |
| CN110960603A (en) * | 2020-01-06 | 2020-04-07 | 泰州欣康生物技术有限公司 | Anti-haze damage composition, preparation method and use method thereof |
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Application publication date: 20170517 |