CN106667485A - Magnetoacoustic coupling effect based electrical stimulation current real-time monitoring device and method - Google Patents
Magnetoacoustic coupling effect based electrical stimulation current real-time monitoring device and method Download PDFInfo
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- CN106667485A CN106667485A CN201710061427.6A CN201710061427A CN106667485A CN 106667485 A CN106667485 A CN 106667485A CN 201710061427 A CN201710061427 A CN 201710061427A CN 106667485 A CN106667485 A CN 106667485A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/42—Details of probe positioning or probe attachment to the patient
- A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue
- A61B8/4281—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue characterised by sound-transmitting media or devices for coupling the transducer to the tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4416—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
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Abstract
The invention relates to a magnetoacoustic coupling effect based electrical stimulation current real-time monitoring device and method. The electrical stimulation current real-time monitoring device includes an N pole magnet and an S pole magnet; a sector scan ultrasonic probe is arranged near a static magnetic field; an amplifier, a filter, an acquisition processor, and a displayer are successively connected in series and arranged near the static magnetic field; a signal input end of the amplifier is connected to a signal output end of the sector scan ultrasonic probe; a trigger signal output end of the acquisition processor is connected to a signal input end of an electrical simulator; and a signal output end of the electrical simulator is connected to a positive electrode and a negative electrode. A output signal of the electrical simulator includes a mark pulse and a simulation pulse in a time axis, the mark pulse is achieved by a high-frequency pulse, and the central frequency of the mark pulse width is consistent with the measurement frequency band of the sector scan ultrasonic probe; a trigger output signal of the acquisition processor and a magnetic stimulation output signal of the electrical simulator are synchronous, and the acquisition trigger time of the acquisition processor and the start time of the mark pulse are identical. The magnetoacoustic coupling effect based electrical stimulation current real-time monitoring device and method can monitor distribute characteristics of tissue current under the electrical simulation, and can achieve positioning simulation of a certain nerve zone.
Description
Technical field
The present invention relates to a kind of electrical stimulation current real-time monitoring device.It is more particularly to a kind of based on magnetosonic coupling effect
Electrical stimulation current real-time monitoring device and method.
Background technology
Electrophysiology for nervous system structures, the research of function in terms of be in critical role.Particularly electrical stimulation method,
Used as the means for adjusting nerve excitability, which applies quite varied, is widely used in the diagnosis and treatment of clinical disease, such as Neuromuscular at present
Meat conductive obstruction is diagnosed, and experiences control for the treatment of, pain and epilepsy of afunction and paralysis motorica etc. etc..Conventional electricity irritation
Technology is mainly affixed on skin surface or using needle electrode insertion tissue using patch electrode, applies electric current to tissue.When electric current it is big
In neural excitation threshold value, then neural excitation is produced, neural activity is adjusted by the method, and then realizes treatment and the mesh for diagnosing
's.
But for electric current distribution situation in the tissue indefinite, for the high-resolution prison of CURRENT DISTRIBUTION in tissue
Survey and imaging, there is no effective means to realize, conceptual phase is also in the orientation problem of specific nerve.To understand monitoring tissue electricity
Flow distribution characteristic, realizes that the positioning of characteristic nerve stimulates, while assessing monitoring effect of stimulation, real-time regulation stimulus parameter has
Significance.
The content of the invention
The technical problem to be solved is to provide a kind of high-resolution that can be realized to CURRENT DISTRIBUTION in tissue
Monitoring and the electrical stimulation current real-time monitoring device based on magnetosonic coupling effect and method that are imaged.
The technical solution adopted in the present invention is：A kind of electrical stimulation current real-time monitoring based on magnetosonic coupling effect is filled
Put, including for the N poles Magnet and S poles Magnet of magnetostatic field are provided to sample, be provided with by the magnetostatic field for sound wave is turned
The signal of telecommunication is turned to while realizing the fan sweeping ultrasonic probe of scanning, is additionally provided with what is be sequentially connected in series：For the letter to detecting
Number amplifier being amplified, for the frequency for retaining marker is filtered to the boost pulse frequency content in the signal after amplification
The wave filter of rate composition, the Acquisition Processor of the triggering collection for realizing signal and image reconstruction and for showing CURRENT DISTRIBUTION
The display of image, wherein, the signal input part of the amplifier connects the signal output part of the fan sweeping ultrasonic probe, described
The trigger outfan of Acquisition Processor is connected to the signal input part of the electrostimulator for providing Neural stem cell electric current, the electricity
The signal output part of stimulator is connected to the positive and negative electrode to sample load energizing current.
The NS poles line direction of N poles Magnet and S poles Magnet, the line direction of the positive and negative electrode and the fan sweeping are super
Sonic probe normal line of butt end direction is orthogonal two-by-two.
A kind of monitoring method of the electrical stimulation current real-time monitoring device based on magnetosonic coupling effect, the electrostimulator
Output signal is made up of marker and boost pulse on a timeline, and the marker is realized by a high-frequency impulse, institute
The mid frequency for stating marker width is consistent with the measurement frequency range of fan sweeping ultrasonic probe；The trigger output signal of Acquisition Processor
It is synchronous with the Neural stem cell output signal of electrostimulator, the trigger collection moment of Acquisition Processor and the marker initial time
It is identical.
Signal period sinusoidal signal realization of the marker by 0.5 μ s, positive stringy pulse of the boost pulse by 10 μ s
Punching is realized.
The time t of electrostimulator output signal with space length l corresponding relations is
L=tv
Wherein v is sound spread speed in the sample.
A kind of electrical stimulation current real-time monitoring device and method based on magnetosonic coupling effect of the present invention, to monitoring electricity thorn
Sharp undertissue's current distribution characteristic, realizes that the positioning of specific neurological region stimulates, and assessment monitoring effect of stimulation, real-time regulation stimulate
Parameter, it is significant.
Description of the drawings
Fig. 1 is overall structure diagram of the present invention based on the electrical stimulation current real-time monitoring device of magnetosonic coupling effect；
Fig. 2 is the signal waveforms of electrical stimulation current real-time monitoring of the present invention.
In figure
1：Sample 2：N poles Magnet
3：S poles Magnet 4：Fan sweeping ultrasonic probe
5：Amplifier 6：Wave filter
7：Acquisition Processor 8：Display
9：Electrostimulator 10：Positive and negative electrode
Specific embodiment
A kind of electrical stimulation current based on magnetosonic coupling effect of the present invention is supervised in real time with reference to embodiment and accompanying drawing
Survey device and method to be described in detail.
As shown in figure 1, a kind of electrical stimulation current real-time monitoring device based on magnetosonic coupling effect of the present invention, including use
In N poles Magnet 2 and S poles Magnet 3 that magnetostatic field is provided to sample 1, it is provided with by the magnetostatic field for sound wave is converted
Realize the fan sweeping ultrasonic probe 4 of scanning for the signal of telecommunication simultaneously, be additionally provided with what is be sequentially connected in series：For the signal to detecting
The amplifier 5 being amplified, the frequency for reservation marker is filtered to the boost pulse frequency content in the signal after amplification
The wave filter 6 of rate composition, the Acquisition Processor 7 of the triggering collection for realizing signal and image reconstruction and for showing electric current point
The display 8 of cloth image, wherein, the signal input part of the amplifier 5 connects the signal output of the fan sweeping ultrasonic probe 4
End, the trigger outfan of the Acquisition Processor 7 are connected to the signal input of the electrostimulator 9 for providing Neural stem cell electric current
End, the signal output part of the electrostimulator 9 are connected to the positive and negative electrode 10 to 1 load energizing current of sample.
The NS poles line direction of N poles Magnet 2 and S poles Magnet 3, the line direction of the positive and negative electrode 10 and the fan
Sweep 4 normal line of butt end direction of ultrasonic probe orthogonal two-by-two.If the NS poles line direction of N poles Magnet 2 and S poles Magnet 3 is along-z sides
To in the x-direction, then 4 normal line of butt end direction of the fan sweeping ultrasonic probe is y directions to 10 line of positive and negative electrode.
In embodiments of the invention, the electrostimulator 9 is by the WF1973 functional generators connection NF companies of NF companies
HSA4101 power amplifiers are realized.The positive and negative electrode 10 can be realized using auspicious suitable 500 type patch electrode.N poles Magnet 2
Realized by K＆J companies of U.S. DZ08-N52 with S poles Magnet 3.The fan sweeping ultrasonic probe 4 is realized by GE 3S phased array probes.Institute
State amplifier 5 to be realized by AD companies AD624.The wave filter 6 is by NF companies.The Acquisition Processor 7 is by NI PXIe 1062Q
Realize with PXI5122.The display 8 is realized by Samsung S24D360HL.
In embodiments of the invention, electrostimulator 9 it is also possible to use day and get over ZM-C-IA realizations.Positive and negative electrode 10 can also be adopted
Acupuncture needle is realized.
A kind of monitoring method of electrical stimulation current real-time monitoring device based on magnetosonic coupling effect of the present invention, such as Fig. 2
Shown, the output signal of the electrostimulator is made up of marker and boost pulse on a timeline, the marker by
One high-frequency impulse realizes that the mid frequency of the marker width is consistent with the measurement frequency range of fan sweeping ultrasonic probe；Collection
The trigger output signal of processor is synchronous with the Neural stem cell output signal of electrostimulator, the trigger collection moment of Acquisition Processor with
The marker initial time is identical.Signal period sinusoidal signal realization of the marker by 0.5 μ s, the stimulation arteries and veins
Rush and realized by the sine pulse of 10 μ s.
The time t of electrostimulator output signal with space length l corresponding relations is
L=tv
Wherein v is sound spread speed in the sample, for soft tissue, is 1500 meter per seconds.
When the electrical stimulation current real-time monitoring device based on magnetosonic coupling effect and method of the present invention work, during t0 first
The signal period sinusoidal signal marker for producing 0.5 μ s is carved, marker excitation produces magnetoacoustic signals response, the magnetoacoustic signals
Response is received, and the sine pulse of 10 μ s of t1 moment is output as boost pulse afterwards, carries out nerve stimulation.Due to labelling arteries and veins
Punching and boost pulse be distributed in the tissue it is identical, therefore by detect marker signal, you can realize boost pulse in the tissue
The monitoring of distribution, and marker is shorter than boost pulse, the spatial resolution being distributed using marker monitoring current is high, reachable
To mm ranks.
Although being described to the preferred embodiments of the present invention above in conjunction with accompanying drawing, the invention is not limited in
The specific embodiment stated, above-mentioned specific embodiment is only schematic, is not restricted.This area it is common
Technical staff in the case of without departing from present inventive concept and scope of the claimed protection, may be used also under the enlightenment of the present invention
To make many forms, these are belonged within protection scope of the present invention.
Claims (5)
1. a kind of electrical stimulation current real-time monitoring device based on magnetosonic coupling effect, including for providing magnetostatic to sample (1)
N poles Magnet (2) and S poles Magnet (3) of field, it is characterised in that be provided with by the magnetostatic field for sound wave is converted into telecommunications
The fan sweeping ultrasonic probe (4) of scanning number is simultaneously realized, is additionally provided with what is be sequentially connected in series：Carry out for the signal to detecting
The amplifier (5) of amplification, the frequency for reservation marker is filtered to the boost pulse frequency content in the signal after amplification
The Acquisition Processor (7) of the wave filter (6), the triggering collection for realizing signal and image reconstruction of composition and for showing electric current
The display (8) of distributed image, wherein, the signal input part of the amplifier (5) connects the letter of the fan sweeping ultrasonic probe (4)
Number outfan, the trigger outfan of the Acquisition Processor (7) are connected to the electrostimulator (9) for providing Neural stem cell electric current
Signal input part, the signal output part of the electrostimulator (9) is connected to the positive negative electricity to sample (1) load energizing current
Pole (10).
2. a kind of electrical stimulation current real-time monitoring device based on magnetosonic coupling effect according to claim 1, its feature
It is, the NS poles line direction of N poles Magnet (2) and S poles Magnet (3), the line direction of the positive and negative electrode (10) and institute
State fan sweeping ultrasonic probe (4) normal line of butt end direction orthogonal two-by-two.
3. the monitoring method of the electrical stimulation current real-time monitoring device based on magnetosonic coupling effect described in a kind of claim 1,
Characterized in that, the output signal of the electrostimulator is made up of marker and boost pulse on a timeline, the labelling
Pulse realized by a high-frequency impulse, the mid frequency of the marker width and the measurement frequency range one of fan sweeping ultrasonic probe
Cause；The trigger output signal of Acquisition Processor is synchronous with the Neural stem cell output signal of electrostimulator, and the collection of Acquisition Processor is touched
Send out the moment identical with the marker initial time.
4. the monitoring method of the electrical stimulation current real-time monitoring device based on magnetosonic coupling effect according to claim 3,
Characterized in that, the marker is realized by the signal period sinusoidal signal of 0.5 μ s, sine of the boost pulse by 10 μ s
Pulse is realized.
5. the monitoring method of the electrical stimulation current real-time monitoring device based on magnetosonic coupling effect according to claim 3,
Characterized in that, the time t of electrostimulator output signal with space length l corresponding relations is
L=tv
Wherein v is sound spread speed in the sample.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710061427.6A CN106667485A (en) | 2017-01-26 | 2017-01-26 | Magnetoacoustic coupling effect based electrical stimulation current real-time monitoring device and method |
| CN201710553215.XA CN107260170B (en) | 2017-01-26 | 2017-07-07 | A kind of electrical stimulation current real-time monitoring device and method based on magnetosonic coupling effect |
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|---|---|---|---|
| CN201710061427.6A CN106667485A (en) | 2017-01-26 | 2017-01-26 | Magnetoacoustic coupling effect based electrical stimulation current real-time monitoring device and method |
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| CN201710061427.6A Withdrawn CN106667485A (en) | 2017-01-26 | 2017-01-26 | Magnetoacoustic coupling effect based electrical stimulation current real-time monitoring device and method |
| CN201710553215.XA Active CN107260170B (en) | 2017-01-26 | 2017-07-07 | A kind of electrical stimulation current real-time monitoring device and method based on magnetosonic coupling effect |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108865881A (en) * | 2018-07-10 | 2018-11-23 | 深圳大学 | Cell function regulator control system and regulation method based on sound magnetic coupling electro photoluminescence principle |
| CN108904974A (en) * | 2018-05-24 | 2018-11-30 | 中国医学科学院生物医学工程研究所 | In conjunction with the electrical stimulation current monitoring device and monitoring method of ultrasonic magnetosonic |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110236540B (en) * | 2019-06-30 | 2023-03-24 | 中国医学科学院生物医学工程研究所 | Deep vein thrombus removing and developing device based on magnetoacoustic coupling effect |
| CN111175371A (en) * | 2020-01-10 | 2020-05-19 | 中国医学科学院生物医学工程研究所 | Two-dimensional focusing scanning magnetic acoustic imaging device |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9669226B2 (en) * | 2010-09-07 | 2017-06-06 | Empi, Inc. | Methods and systems for reducing interference in stimulation treatment |
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- 2017-01-26 CN CN201710061427.6A patent/CN106667485A/en not_active Withdrawn
- 2017-07-07 CN CN201710553215.XA patent/CN107260170B/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904974A (en) * | 2018-05-24 | 2018-11-30 | 中国医学科学院生物医学工程研究所 | In conjunction with the electrical stimulation current monitoring device and monitoring method of ultrasonic magnetosonic |
| CN108865881A (en) * | 2018-07-10 | 2018-11-23 | 深圳大学 | Cell function regulator control system and regulation method based on sound magnetic coupling electro photoluminescence principle |
| CN108865881B (en) * | 2018-07-10 | 2022-04-12 | 深圳大学 | Cell function regulation and control system and method based on acoustomagnetic coupling electrical stimulation principle |
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| Publication number | Publication date |
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| CN107260170B (en) | 2019-09-17 |
| CN107260170A (en) | 2017-10-20 |
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