CN106645128A - Detection reagent and test paper for uric acid - Google Patents
Detection reagent and test paper for uric acid Download PDFInfo
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- CN106645128A CN106645128A CN201710000766.3A CN201710000766A CN106645128A CN 106645128 A CN106645128 A CN 106645128A CN 201710000766 A CN201710000766 A CN 201710000766A CN 106645128 A CN106645128 A CN 106645128A
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- uric acid
- test paper
- layer
- detection reagent
- conversion zone
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
Abstract
The invention discloses a detection reagent and test paper for uric acid. The detection reagent comprises 12 to 18 KU/L of urate oxidase, 5 to 10 KU/L of horseradish peroxidase, 15 to 20 KU/L of ascorbic acid oxidase, 0.20 to 0.35 g/L of 4-aminoantipyrine and 0.20 to 0.30 g/L of a chromogenic substance. The detection reagent provided by the invention contains a plurality of specific enzymes in a specific ratio and can achieve the purpose of rapid and accurate detection of the content of uric acid. The test paper for uric acid comprises a reaction substrate layer, a reaction layer, a hemofiltration layer and a sample suction layer. The above-mentioned layers are superposed to form a siphon system, so the test paper has better anti-interference capability, effectively eliminates interference by endogenous substances and further guarantees rapid and accurate detection of the content of uric acid.
Description
Technical field
The present invention relates to the technical field of uric acid detection, the detection of detection reagent and uric acid in particular to uric acid
Test paper.
Background technology
It is presently used for detecting that the method in blood with the presence or absence of certain composition or the content of the composition is examined including liquid reagent
Survey and drying chemical reagent paper detection.Drying chemical reagent paper have it is easy to use, simple to operate, the characteristics of quickly go out result.
According to flow path of the detection liquid sample on drying chemical reagent paper, drying chemical reagent paper can be divided into multiple types
Type, longitudinally perpendicular Test paper is one kind of drying chemical reagent paper.Longitudinally perpendicular Test paper is included the load with reaction reagent
Body phase is mutually superimposed, and liquid sample is top-down to flow through each reaction reagent layer, finally shows testing result.For example it is beautiful
The method that state's patent US4816224 adopts longitudinally perpendicular Test paper.
The area of longitudinally perpendicular its reaction reagent carrier of Test paper is all less, therefore only needs to less liquid sample use
Amount can just complete detection.Because individual difference, during finger tip is taken a blood sample, the sample size of collection is very rambunctious, example
Such as, the finger tip blood sampling volume of occidentals is often more than Asian.And absorption of the reaction reagent carrier to liquid has certain saturation
Degree, when the blood sample being added dropwise on test paper is excessive, existing dry chemical Test paper can not in time process unnecessary blood sample.Such as
Longitudinally perpendicular Test paper of the prior art, the test paper includes：Base plate adheres to and supports conversion zone, is coated with conversion zone
Sample separating layer, fiberglass layer and clathrum.Glass and sample separating layer are vertically flowed through after liquid is added drop-wise to clathrum, is finally reached
There is chemical reaction to conversion zone.If the blood sample amount for adding is more, reaching the conversion zone of hold-up, to be unable to re-absorption more
During remaining sample, these unnecessary blood samples will overflow checking test paper, pollution environment or touch tester.Unnecessary blood
Can also be gathered in reaction reagent layer and form drop, not only affect the interpretations of the detecting instrument to result such as optics, can also be serious
Pollution detection instrument.
Patent CN 102128918A employs a kind of lock liquid structure, and this structure test paper includes：Adhere on base plate and support
Conversion zone, sample-adding layer is coated with conversion zone relative to the opposite side of base plate, there is an adding mouth in sample-adding layer.Conversion zone is the bottom of along
At least side in plate direction overlaps lock liquid part, and lock liquid part is fixed on base plate.In base plate relative to having at conversion zone
One is used to read the detection window of reaction result.All structures are by the position between the stronger fixing them of bonding sheet.Work as liquid
It is first vertical to flow into conversion zone and absorbed by conversion zone when body sample is added to sample-adding layer.When conversion zone hold-up, liquid leads to
The mode for crossing horizontal flow measurement is diffused in the lock liquid part with conversion zone overlap joint.The speed that liquid is absorbed due to locking liquid part is less than
Or equal to the absorption liquid velocity of conversion zone, so when surplus liquid is diffused into lock liquid part, the liquid in conversion zone is
The detection reaction of correlation is carried out enough, the effective dose needed for so as to have no effect on detection reaction.When excessive sample is added,
Unnecessary sample is locked liquid part and is absorbed, therefore unnecessary sample will not form drop and overflow outside test paper.But this kind of lock liquid
Structural manufacturing process is complicated, it is desirable to speed of the speed less than or equal to conversion zone absorption liquid that liquid part absorbs liquid is locked, to locking liquid
The material requirements of part is higher, and increased operation in test paper production technology, makes test paper production technology increasingly complex.
In addition, in above prior art, accuracy in detection has much room for improvement, detect not quick enough.
The content of the invention
In view of this, one aspect of the present invention is the detection reagent and the Test paper of uric acid for providing a kind of uric acid, the inspection
Test paper can quick detection uric acid content, with simple to operate, detection is quick, accuracy in detection is higher and it is convenient test it is excellent
Point.
A kind of detection reagent of uric acid, it includes the horseradish peroxidating of the urea acid oxidase of 12～18KU/L, 5～10KU/L
Thing enzyme, the ascorbic acid oxidase of 15～20KU/L, the 4-AA of 0.20～0.35g/L and 0.20～0.30g/L
Substance that show color.
Further, the detection reagent is also comprising 0.15～0.25mmol/L and pH is 6.0～8.0 PBS.
Further, ox blood of the detection reagent also comprising 1.0～1.3g/L trehaloses and 0.15～0.35g/L is pure
Albumen；
Further, the substance that show color is one or more in TOOS, TODB, DAOS, MOAS, phenols, TMB.
Further, including reaction basic unit, it is arranged at the conversion zone on reaction basic unit one surface, is arranged at conversion zone one
The hemofiltration layer on surface, and it is arranged at the hydrophilic layer on the surface of hemofiltration layer one；The reaction basic unit is provided with through hole；The conversion zone
The through hole is covered, detection reagent of the conversion zone by described in above-mentioned any one is coated on membrane material and is formed.
Further, the material of the reaction basic unit is polyvinyl chloride, Merlon, polyesteramide or polyester.
Further, it is provided with a double faced adhesive tape between the reaction basic unit and conversion zone.
Further, a double faced adhesive tape is provided between the hydrophilic layer and hemofiltration layer.
Further, the hydrophilic layer is hydrophilic film or grenadine.
Further, the double faced adhesive tape between the reaction basic unit and conversion zone is provided with hole corresponding with the through hole.
Compared with prior art, the beneficial effect of the Test paper of the detection reagent and uric acid of uric acid of the invention is：
The detection reagent of uric acid of the present invention, it contains various certain enzymes carries out specific proportioning, can reach quick and relatively be defined
Really detect the purpose of the content of uric acid.The Test paper of uric acid of the present invention includes reaction basic unit, conversion zone, hemofiltration layer and inhales sample
Layer, one siphon system of these stackings plus composition, antijamming capability is higher, has effectively eliminated the interference of endogenous material, enters
One step ensure that content that is quick and more accurately detecting uric acid.
Description of the drawings
Fig. 1 is the decomposition texture schematic diagram of embodiment of the present invention Test paper.
Main element symbol description：
1 Test paper
100 reaction basic units
110 through holes
200,500 double faced adhesive tapes
210 holes
300 conversion zones
310 detection reagents
320 membrane materials
400 hemofiltration layers
600 hydrophilic layers
Specific embodiment
Unless otherwise defined, all technologies used herein and scientific terminology have and the common skill of art of the present invention
The identical implication that art personnel are generally understood that.When there is contradiction, the definition in this specification is defined.
Term as used herein：
" by ... prepare " it is synonymous with "comprising".Term "comprising" used herein, " including ", " having ", " containing "
Or its any other deformation, it is intended that cover including for non-exclusionism.For example, the composition comprising listed elements, step, method,
Product or device are not necessarily solely those key elements, and can be including not expressly listed other key elements or this kind of composition, step
Suddenly, the intrinsic key element of method, product or device.
Conjunction " by ... constitute " exclude any key element do not pointed out, step or component.If in being used for claim,
This phrase will make claim for closed so as to not comprising the material in addition to the material that those are described, but relative
Except customary impurities.When phrase " by ... constitute " theme is rather than immediately following in the clause that occurs in claim main body after
When, it is only limited to the key element described in the clause；Other key elements be not excluded as the overall claim it
Outward.
Equivalent, concentration or other values or parameter are excellent with scope, preferred scope or a series of upper limit preferred values and lower limit
During the Range Representation that choosing value is limited, this is appreciated that and specifically discloses by any range limit or preferred value and any scope
All scopes that arbitrary pairing of lower limit or preferred value is formed, regardless of whether whether the scope separately discloses.For example, when open
During scope " 1～5 ", described scope should be interpreted as including scope " 1～4 ", " 1～3 ", " 1～2 ", " 1～2 and 4～
5 ", " 1～3 and 5 " etc..When number range is described herein, unless otherwise indicated, otherwise the scope is intended to include its end
Value and all integers within the range and fraction.
" mass parts " refer to the basic measurement unit of the mass ratio relation for representing multiple components, and 1 part can represent arbitrary list
Position quality, can such as be expressed as 1g, may also indicate that 2.689g etc..If we say component A mass parts be a parts, the matter of B component
Amount part is b parts, then it represents that the quality of component A and mass ratio a of B component：b.Or, represent component A quality be aK, B groups
The quality divided is bK (K is Arbitrary Digit, represents multiplying factor).Can not misread, and unlike mass fraction, all components
Mass parts sum be not limited to 100 parts of restriction.
"and/or" is used to represent that one of illustrated situation or both may to occur, and for example, A and/or B includes (A
And B) and (A or B)；
Additionally, key element of the present invention or indefinite article " one kind " and " one " before component are to key element or the quantitative requirement of component
(i.e. occurrence number) unrestriction.Therefore " one " or " one kind " should be read as including one or at least one, and odd number
The key element or component of form also includes plural form, unless the obvious purport of the quantity refers to singulative.
The detection reagent 52 of uric acid of the present invention, it includes a kind of detection reagent of uric acid, and it includes the urea of 12～18KU/L
Acid oxidase, the horseradish peroxidase of 5～10KU/L, the ascorbic acid oxidase of 15～20KU/L, 0.20～0.35g/L
4-AA and 0.20～0.30g/L substance that show colors.
Specifically, the content of urea acid oxidase (being also called peroxidase) can be enumerated as 12KU/L, 13KU/L,
14KU/L, 15KU/L, 16KU/L, 17KU/L or 18KU/L etc.；The content of horseradish peroxidase (being also called uricase) can be with
It is enumerated as 5KU/L, 6KU/L, 7KU/L, 8KU/L, 9KU/L or 10KU/L etc.；The content of ascorbic acid oxidase can be enumerated as
15KU/L, 16KU/L, 17KU/L, 18KU/L, 19KU/L or 20KU/L etc.；The content of 4-AA can be 0.20g/
L, 0.22g/L, 0.25g/L, 0.28g/L, 0.30g/L, 0.33g/L or 0.35g/L etc.；The content of substance that show color can be
0.20g/L .022g/L, 0.25g/L, 0.28g/L, 0.29g/L or 0.30g/L etc..
Wherein, substance that show color can include one or more in TOOS, TODB, DAOS, MOAS, phenols, TMB.This
In, TOOS is N- ethyl-N- TOOSs, and its No. CAS is 82692-93-1；TODB is
Double (4- the sulphur butyls) -3- methylaniline disodium salts of N, N-, its No. CAS is 127544-88-1；DAOS is N- ethyl-N- (2- hydroxyls
Base -3- sulfopropyls) -3'5- dimethoxyaniline sodium salts, its No. CAS is 83777-30-4；TMB is 3,3', and 5,5'- tetramethyls join
Aniline, its No. CAS is 54827-17-7；Phenols is phenolic developer.
Preferably, the detection reagent 310 of uric acid of the present invention, except including above-mentioned raw materials, can also buffer comprising PBS
Liquid, with the pH stability of maintenance system.The content of PBS is preferred with 0.15～0.25mmol/L, such as 0.15mmol/L,
0.18mmol/L, 0.20mmol/L, 0.22mmol/L, 0.24mmol/L or 0.25mmol/L etc., preferably 0.20mmol/L etc..
The pH of PBS is preferably 6.0～8.0, such as 6.0,6.2,6.5,7,7.5,7.8 or 8.0.
Preferably, the detection reagent 310 of uric acid of the present invention, except above-mentioned raw materials can be included, can also comprising 1.0～
The content of the trehalose of 1.3g/L, such as trehalose can be 1.0g/L, 1.1g/L, 1.2g/L or 1.3g/L etc..
Preferably, the detection reagent 310 of uric acid of the present invention, except above-mentioned raw materials can be included, can also comprising 0.15～
0.35g/L bovine serum albumin(BSA)s (BSA), such as 0.15g/L, 0.18g/L, 0.20g/L, 0.22g/L, 0.25g/L, 0.28g/L,
0.30g/L, 0.33g/L or 0.35mmol/L etc., preferably 0.20g/L etc..Bovine serum albumin(BSA), it is also known as BSA
A kind of albumin in cow's serum, comprising 583 amino acid residues, molecular weight is 66.430kDa, and isoelectric point is 4.7, at this
Osmotic pressure effect, PH cushioning effects, carrier function and the trophism of maintenance system are acted primarily as in bright.
The Test paper 1 of the uric acid of the present invention, including react basic unit 100, be arranged at reaction basic unit 100 1 surface
Conversion zone 300, be arranged at conversion zone 300 a surface hemofiltration layer 500, and the parent for being arranged at the surface of hemofiltration layer 500 1
Water layer 600；The reaction basic unit 100 is provided with through hole 110；The conversion zone 300 covers the through hole 110, the conversion zone 300
Detection reagent 310 by described in above-mentioned any one is coated on membrane material 320 and is formed.
It is to be appreciated that the effect of above-mentioned reaction basic unit 100 is to support whole Test paper 1.The material of reaction basic unit 100
Matter can be enumerated as polyvinyl chloride (PVC), Merlon (PC), polyesteramide (PA) or polyester (general designation of PBT and PET), preferably
For polyester, more preferably pet substrate.
The form of reaction basic unit 100 can be film or thin plate, and reaction basic unit 100 is provided with through hole 110, using anti-as light
Penetrate detection to be used.
Preferably, a double faced adhesive tape 200 can be set between conversion zone 300 and reaction basic unit 100.The area of the double faced adhesive tape 200
Can be more than conversion zone 300 less than reaction basic unit 100.Conversion zone 300 is bonded in the reaction basic unit by double faced adhesive tape 200
On 100, conversion zone 300 avoids through hole 110 with the bonding part of reaction basic unit 100.The double faced adhesive tape 200 can also arrange logical with described
The corresponding hole 210 in hole.
The membrane material 320 can be enumerated as emulsion and polypropylene cellulose film or, vinyl fiber film nitrocellulose filter, nylon membrane,
One kind in carboxylated cellulose film or pure cellulose film.It is preferred that membrane material 320 is emulsion and polypropylene cellulose film or polyethylene fibre
Film.The surface of the membrane material is used for dripping to enclose stating detection reagent 310.
Used as the Test paper 1 of the present invention, the form of hemofiltration layer 400 can be film.The area of hemofiltration layer 400 can be more than
Conversion zone, its two ends is pasted onto double faced adhesive tape 200 when such hemofiltration layer 400 is covered in conversion zone 300.The area of hemofiltration layer 400
It is smaller than bonding the size of its double faced adhesive tape 200.
Preferably, a double faced adhesive tape 500 can be provided between hydrophilic layer 600 and hemofiltration layer 400.The double faced adhesive tape can be U-shaped
Double faced adhesive tape or square double-sided glue, and it is respectively adhered on the upper and lower ends of hemofiltration layer 400.It should be noted that hydrophilic layer 600 and double
The siphon groove that the U-shaped mouth of face glue 400 builds reaches hemofiltration layer 400.
Preferably, hydrophilic layer 600 can be hydrophilic film or grenadine.
Below do not address part and be applied to prior art.
Embodiment 1
A kind of Test paper 1 of uric acid, its preparation method is comprised the following steps：
Step one, stick double faced adhesive tape 200 and get through the standby of hole 110 in the reaction basic unit 100 of the PET materials of certain hardness
With.
Step 2, the oilpaper for tearing double faced adhesive tape 200 in reaction basic unit 100, by membrane material 320 the two-sided of PET sheet is pasted onto
On glue 200, membrane material 320 needs to cover all the through hole 110 on pet substrate.
Step 3, first preparation detection reagent 310：Urea acid oxidase comprising 12KU/L, the horseradish peroxidase of 10KU/L
Enzyme, the ascorbic acid oxidase of 15KU/L, the 4-AA of 0.20g/L, the PBS of 0.15mmol/L, 1.0g/
The trehalose of L, 0.35g/L BSA and 0.30g/L substance that show colors.The detection reagent 310 for preparing is added drop-wise to into film with point gum machine
It is 6mg per hole dripping quantity at the correspondence through hole 110 of material 320, the lamina membranacea for dripping off liquid is put into drying tunnel drying, baking temperature：37 DEG C,
Drying time 20min, obtains conversion zone 300.
Step 4, hemofiltration film is sticked in conversion zone 300, and hemofiltration film is covered all into conversion zone 300.
Step 5, on hemofiltration film U-shaped double faced adhesive tape is sticked around through hole 110 again, using siphon principle, use U-shaped double faced adhesive tape
A micro sample absorbing device is constituted with hydrophilic layer 600 (hydrophilic film or grenadine), the amount for inhaling sample can be fixed.
Embodiment 2
In the preparation method of the Test paper 1 of the present embodiment uric acid, urea acid oxidase of the detection reagent 310 comprising 14KU/L
Enzyme, the horseradish peroxidase of 9KU/L, the ascorbic acid oxidase of 16KU/L, the 4-AA of 0.25g/L,
The PBS of 0.18mmol/L, the trehalose of 1.1g/L, 0.33g/L BSA and 0.28g/L substance that show colors.Other steps are equal
With embodiment 1.
Embodiment 3
In the preparation method of the Test paper 1 of the present embodiment uric acid, urea acid oxidase of the detection reagent 310 comprising 15KU/L
Enzyme, the horseradish peroxidase of 8KU/L, the ascorbic acid oxidase of 18KU/L, the 4-AA of 0.28g/L,
The PBS of 0.19mmol/L, the trehalose of 1.2g/L, 0.30g/L BSA and 0.25g/L substance that show colors.Other steps are equal
With embodiment 1.
Embodiment 4
In the preparation method of the Test paper 1 of the present embodiment uric acid, urea acid oxidase of the detection reagent 310 comprising 16KU/L
Enzyme, the horseradish peroxidase of 6KU/L, the ascorbic acid oxidase of 19KU/L, the 4-AA of 0.30g/L,
The PBS of 0.19mmol/L, the trehalose of 1.3g/L, 0.28g/L BSA and 0.22g/L substance that show colors.Other steps are equal
With embodiment 1.
Embodiment 5
In the preparation method of the Test paper 1 of the present embodiment uric acid, urea acid oxidase of the detection reagent 310 comprising 18KU/L
Enzyme, the horseradish peroxidase of 5KU/L, the ascorbic acid oxidase of 20KU/L, the 4-AA of 0.35g/L,
The PBS of 0.20mmol/L, the trehalose of 1.2g/L, 0.25g/L BSA and 0.20g/L substance that show colors.Other steps are equal
With embodiment 1.
Comparative example
Certain hospital's test sample.
Evaluation method：
The Test paper 1 of the uric acid of embodiment 5 is inserted directly in self-control dry type chemical analysis instrument, result exists after 6 minutes
Show on instrument.Table 1 is to make the test result of dry type chemical analysis instrument by oneself with comparative example test result comparison diagram, and it is related
Property reaches 0.998.Can be directly used for clinically testing.
Table 1, hospital's test sample test result compared with triglycerides test result of the present invention
The Test paper 100 of uric acid of the present invention has the advantage that：Antijamming capability is higher, has effectively eliminated red blood cell
And the interference of endogenous material, and the concentration of the uric acid of whole blood can accurately be tested in 6 minutes, test result and tradition
Method to compare test result more accurate.Portable dry type chemical analyzer homemade with company is used together, and more meets clinic
The requirement on side, is adapted to hospital emergency, ward, community hospital, domestic consumer etc. and uses.
Because the number range of each technological parameter involved in the present invention can not possibly all embody in the above-described embodiments,
As long as but those skilled in the art's envisioned any numerical value fallen in the above-mentioned number range completely can implement this
Invention, also includes any combination of occurrence in the range of some numerical value certainly.Herein, for the consideration of length, eliminate to
Go out the embodiment of occurrence in certain one or more number range, this disclosure for being not to be construed as technical scheme is not filled
Point.
Applicant states that the present invention illustrates the detailed process equipment of the present invention and technological process by above-described embodiment,
But above-mentioned detailed process equipment and technological process are the invention is not limited in, that is, does not mean that the present invention has to rely on above-mentioned detailed
Process equipment and technological process could be implemented.Person of ordinary skill in the field it will be clearly understood that any improvement in the present invention,
Addition, concrete mode selection of equivalence replacement and auxiliary material component composition to each raw material of product of the present invention etc., fall the present invention's
In protection domain.
Claims (10)
1. a kind of detection reagent of uric acid, it is characterised in that：It includes the urea acid oxidase of 12～18KU/L, 5～10KU/L
Horseradish peroxidase, the ascorbic acid oxidase of 15～20KU/L, the 4-AA of 0.20～0.35g/L and 0.20
～0.30g/L substance that show colors.
2. the detection reagent of uric acid according to claim 1, it is characterised in that：Its also comprising 0.15～0.25mmol/L and
PH is 6.0～8.0 PBS.
3. the detection reagent of uric acid according to claim 1, it is characterised in that：It also includes 1.0～1.3g/L trehaloses
With the bovine serum albumin(BSA) of 0.15～0.35g/L.
4. the nitrogen detection reagent of uric acid according to claim 1, it is characterised in that：The substance that show color be TOOS, TODB,
One or more in DAOS, MOAS, phenols, TMB.
5. a kind of Test paper of uric acid, it is characterised in that：Including reaction basic unit, it is arranged at the anti-of reaction basic unit one surface
Answer layer, be arranged at the hemofiltration layer on the surface of conversion zone one, and be arranged at the hydrophilic layer on the surface of hemofiltration layer one；The reaction basic unit
It is provided with through hole；The conversion zone covers the through hole, detection examination of the conversion zone by described in Claims 1 to 4 any one
Agent is coated on membrane material and is formed.
6. the Test paper of uric acid according to claim 5, it is characterised in that：The material of the reaction basic unit is polychlorostyrene second
Alkene, Merlon, polyesteramide or polyester.
7. the Test paper of uric acid according to claim 5, it is characterised in that：Set between the reaction basic unit and conversion zone
There is a double faced adhesive tape.
8. the Test paper of uric acid according to claim 5, it is characterised in that：It is provided between the hydrophilic layer and hemofiltration layer
One double faced adhesive tape.
9. the Test paper of uric acid according to claim 5, it is characterised in that：The hydrophilic layer is hydrophilic film or grenadine.
10. the Test paper of uric acid according to claim 7, it is characterised in that：Between the reaction basic unit and conversion zone
Double faced adhesive tape be provided with hole corresponding with the through hole.
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| CN201710000766.3A CN106645128A (en) | 2017-01-03 | 2017-01-03 | Detection reagent and test paper for uric acid |
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| CN108303454A (en) * | 2018-02-23 | 2018-07-20 | 南京鱼跃软件技术有限公司 | A kind of uric acid electrochemical sensor |
| CN108593633A (en) * | 2018-04-19 | 2018-09-28 | 中山大学 | A kind of Test paper for quickly detecting saliva uric acid |
| CN109187389A (en) * | 2018-09-07 | 2019-01-11 | 大连大学 | A kind of detection kit of marine low temperature urate oxidase measurement uric acid |
| CN109916891A (en) * | 2019-04-12 | 2019-06-21 | 吉林省汇酉生物技术股份有限公司 | A kind of dry chemistry reagent piece and preparation method thereof quantitative determining uric acid concentration |
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| CN113106143A (en) * | 2021-04-01 | 2021-07-13 | 广州南雪医疗器械有限公司 | Test paper for detecting uric acid |
| CN113125427A (en) * | 2021-04-07 | 2021-07-16 | 中国科学院苏州生物医学工程技术研究所 | Dry chemical reagent sheet for simultaneously detecting uric acid, blood sugar and triglyceride |
| CN113884686A (en) * | 2021-10-18 | 2022-01-04 | 四川成电医联科技咨询有限公司 | Siphon type total homocysteine test paper and manufacturing method thereof |
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