CN106644626A - Permanent magnet closed experimental device for protein crystallization - Google Patents
Permanent magnet closed experimental device for protein crystallization Download PDFInfo
- Publication number
- CN106644626A CN106644626A CN201610898306.2A CN201610898306A CN106644626A CN 106644626 A CN106644626 A CN 106644626A CN 201610898306 A CN201610898306 A CN 201610898306A CN 106644626 A CN106644626 A CN 106644626A
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- aluminium sheet
- crystallization
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- diamagnetic
- paramagnetic
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
- H01F7/02—Permanent magnets [PM]
- H01F7/0231—Magnetic circuits with PM for power or force generation
- H01F7/0252—PM holding devices
- H01F7/0263—Closures, bags, bands, engagement devices with male and female parts
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2223/00—Investigating materials by wave or particle radiation
- G01N2223/05—Investigating materials by wave or particle radiation by diffraction, scatter or reflection
- G01N2223/056—Investigating materials by wave or particle radiation by diffraction, scatter or reflection diffraction
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2223/00—Investigating materials by wave or particle radiation
- G01N2223/10—Different kinds of radiation or particles
- G01N2223/101—Different kinds of radiation or particles electromagnetic radiation
- G01N2223/1016—X-ray
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2223/00—Investigating materials by wave or particle radiation
- G01N2223/60—Specific applications or type of materials
- G01N2223/612—Specific applications or type of materials biological material
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- Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Electromagnetism (AREA)
- Engineering & Computer Science (AREA)
- Power Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Hard Magnetic Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
Abstract
The invention provides a permanent magnet closed experimental device for protein crystallization. Two permanent magnets are placed in parallel, and the polarities of corresponding positions of the two permanent magnets are opposite; a U-shaped aluminum plate is located between the two permanent magnets, and the aluminum plate and the permanent magnets define a crystallization plate accommodating zone with five sides closed and one side open; multiple paramagnetic steel plates and diamagnetic aluminum plates define a closed structure to wrap the permanent magnets and the U-shaped aluminum plate, and in the closed structure, the diamagnetic aluminum plates are arranged on two sides directly facing the opening of the U-shaped aluminum plate. The permanent magnet closed experimental device is high magnetic field intensity, compact in size, low in manufacturing cost and capable of obviously improving the protein crystallization quality.
Description
Technical field
The present invention relates to Bioexperiment instrument field, and in particular to a kind of permanent magnetism closing for bioprotein crystallization is real
Experiment device.
Background technology
Protein is the main undertaker of vital movement, and with extremely changeable 26S Proteasome Structure and Function, therefore it lives to life
Dynamic importance is self-evident.By the parsing to protein structure and the analysis of function, we can live to life
It is dynamic that there is deeper understanding and research.
At present, the parsing of protein structure is mainly by XRD (X-ray diffraction) come what is completed, and in PDB
The protein structure that 90% is had more than in (Protein Data Bank) database is parsed by XRD.At present XRD is in albumen
There is absolute dominant position during matter structural analysis, but need to utilize protein crystal using XRD parsing protein structures,
Therefore crystallization of protein is become for the committed step of XRD protein structures parsing, on the current technology, how to be obtained high-quality
The protein crystal of amount is still the bottleneck for restricting this technology development.
Document " Effects of a magnetic field on the nucleation and growth of
Protein crystals " etc. report carry out in magnetic field crystallization of protein can significantly produce that quantity is less but volume more
Big protein crystal.Therefore the crystal mass that crystallization of protein is improved by the particular surroundings in magnetic field is to improve XRD albumen
One of effective way of matter diffraction quality.
According to the mode that is differently formed of magnetic force, magnetic field can be divided into electromagnetic field and permanent magnetic field.Electromagnetic field can be divided into routine again
Conductor magnetic field and cryogenic magnetic field, electromagnetic field can produce the magnetic field compared with high magnetic force in the presence of electric current, from several teslas to several
The magnetic field intensity that ten teslas do not wait, although electromagnetic field has higher magnetic field intensity, needs in use special
Place, higher manpower and materials go safeguard, put into it is larger, in-convenience in use.On the other hand for permanent magnetic field, its magnetic field is strong
Degree reaches as high as a little several teslas at present, although it is little much to compare its intensity with electromagnetic field, but permanent magnetic field device
Small volume, once component devices avoid the need for carrying out the input of energy and the numerous and diverse maintenance as electromagnetic field again.Simultaneously
During the protein crystallization experiments of underway low field strength, permanent magnetic field also has important experiment and more practical value.
The content of the invention
In order to overcome the deficiencies in the prior art, it is real that the present invention provides a kind of practical test crystallization of protein permanent magnetism closing
Experiment device, magnetic field intensity of the present invention is big, and volume compact, low cost of manufacture can significantly improve crystallization of protein quality.
The technical solution adopted for the present invention to solve the technical problems is：A kind of permanent magnetism envelope for bioprotein crystallization
Close experimental provision, including permanent magnet, U-shaped aluminium sheet, diamagnetic aluminium sheet and paramagnetic steel plate；Permanent magnet described in two pieces is placed in parallel, and
The opposite polarity of two block permanent magnet correspondence positions；Described U-shaped aluminium sheet is located between two block permanent magnets, and aluminium sheet and permanent magnet are enclosed
Close into five banding, the crystallization plates rest area of openings at one side；Some paramagnetic steel plates and diamagnetic aluminium sheet enclose a closing knot
Structure, permanent magnet and U-shaped aluminium sheet are wrapped in, in described enclosed construction, just diamagnetic aluminium is to the both sides of U-shaped aluminium sheet opening
Plate.
Described permanent magnet adopts neodymium iron boron strong permanent magnetic iron.
Respectively there are two block permanent magnets described U-shaped aluminium sheet both sides, and two block permanent magnets of the same side are generally aligned in the same plane to be adjacent to be put
Put, and the opposite polarity of the adjacent side of two block permanent magnets.
Described permanent magnet leaves space in itself residing plane between enclosed construction.
In described enclosed construction, diamagnetic aluminium sheet is just provided with crystallization plates entrance to the position of U-shaped aluminium sheet opening, and by door
Lid closing.
Described paramagnetic steel plate is fastenedly connected by paramagnetic lead screw, and described diamagnetic aluminium sheet is installed by paramagnetic lead screw
On paramagnetic steel plate.
Described permanent magnet is arranged on paramagnetic steel plate by magnetic cylindrical pins.
The invention has the beneficial effects as follows：First, permanent magnet of the present invention is neodymium iron boron strong permanent magnetic iron, and magnet is thin
Rectangle, up and down respectively close to two pieces, can so reduce monolithic large area pole center position field intensity and weaken problem.Using N-S magnetic
Extremely relative and magnet Parallel Design, while the overall closure paramagnetic steel plate of outside of deivce face surrounding and diamagnetic design in front and back, greatly
The outer dissipation of the magnetic line of force is reduced greatly, the magnetic field intensity inside device had so both been greatly strengthen, and the basic dimension in device inside is made again
Hold permanent steady magnetic field intensity.Secondly, U-shaped diamagnetic aluminium sheet is accompanied between upper lower magnet, the magnetic line of force between such magnet is most of all
The crystallization plates rest area of U-shaped indentation, there is concentrated to, using ANSYS finite element modellings and analysis, device internal crystallization during design
Plate rest area establishes the constant magnetic field for meeting crystallization plates size, after device completes, to the magnetic inside device
Field intensity carries out actual measurement, and the result that as a result and in advance simulation is calculated is basically identical, is so advantageous for later experiments
The requirement of condition homogeneity, increases the degree of accuracy and the experiment effect of experiment.Finally, apparatus of the present invention small volume, is easy to move, can
It is positioned in water circulation water-bath, occupancy lab space is little, easy to use.
Description of the drawings
Fig. 1 is experimental provision surface structure schematic diagram of the present invention.
Fig. 2 is experimental provision internal structure schematic diagram of the present invention.
Fig. 3 is that experimental provision of the present invention opens the internal structure top view after the paramagnetic steel plate of top.
It is interior after top paramagnetic steel plate and withdrawing device internal upper part permanent magnet that Fig. 4 is that experimental provision of the present invention is opened
Portion's structure top view.
Internal core (the permanent magnet and U-shaped aluminium sheet) structural representation of Fig. 5 experimental provisions of the present invention.
The device outer closures system paramagnetic steel plate splicing structural representation of Fig. 6 experimental provisions of the present invention.
In figure, 1.1, diamagnetic cylindrical pins；1.2nd, upper paramagnetic steel plate；1.3rd, big paramagnetic lead screw；1.4th, little paramagnetic screw
Bar；1.5th, entrance door closure；1.6th, front diamagnetic aluminium sheet；1.7th, left paramagnetic steel plate；2.1st, upper paramagnetic plate；2.2nd, right paramagnetic steel plate；
2.3rd, U-shaped aluminium sheet；2.4th, diamagnetic air space；2.5th, lower paramagnetic steel plate；2.6th, lower strong permanent magnetic iron A；2.7th, crystallization plates rest area；
2.8th, upper strong permanent magnetic iron A；3.1st, rear diamagnetic aluminium sheet；3.2nd, device portal；5.1st, upper strong permanent magnetic iron B；5.2nd, lower strong permanent magnetic iron B；
6.1st, U-shaped aluminium sheet locating slot；6.2nd, strong permanent magnetic iron locating slot.
Specific embodiment
With reference to the accompanying drawings and examples the present invention is further described, and the present invention includes but are not limited to following enforcements
Example.
The present invention provides a kind of permanent magnetism enclosed experiment device for bioprotein crystallization, including device closed test system
System and device outer closures system.
Described device Internal Experiment system includes：U-shaped thickness diamagnetic duralumin plate (the U-shaped aluminium of strong permanent magnetic iron, supporting function
Plate), crystallization plates rest area and diamagnetic air space.
Described device outer closures system includes：Paramagnetic steel plate, diamagnetic aluminium sheet, paramagnetic lead screw, diamagnetic cylindrical pins,
Device portal and entrance door closure.
Used as the preferred version of above-mentioned technology, described device Internal Experiment system is wrapped completely by device outer closures system
Wrap up in and be enclosed in inside.
Used as the preferred version of above-mentioned technology, described strong permanent magnetic iron is the generating source of medium-high magnetic field of the present invention, in device
Internal strong permanent magnetic iron is produced on crystallization plates of almost permanent steady strong magnetic field action when experiment, two blocks of magnet each up and down in device,
It is parallel relative.
As the preferred version of above-mentioned technology, described U-shaped aluminium sheet by not homopolarity to just to strong magnet support and separate
Open, prevent it from attracting each other and be attached onto.
Used as the preferred version of above-mentioned technology, described crystallization plates rest area is located in the middle of strong permanent magnetic iron opposing upper and lower, U
Inside the U-shaped of type aluminium sheet, in use for laboratory in the placement of crystallization plates.
Used as the preferred version of above-mentioned technology, described diamagnetic air space is located at upper lower magnet both sides, primarily serves anti-
Magnetic the magnetic line of force is mainly enclosed in device outer closures system in paramagnetic steel plate in.
As the preferred version of above-mentioned technology, described paramagnetic steel plate be anchored on outside of deivce face up and down everywhere,
Tight closure, playing makes the magnetic line of force circulate effect therein.
As the preferred version of above-mentioned technology, described diamagnetic aluminium sheet be anchored on device before and after at two, be close to paramagnetic steel
Plate, it is diamagnetic to prevent magnetic line of force short circuit.
As the preferred version of above-mentioned technology, described paramagnetic lead screw, for fixation device outer closures system is fited
Paramagnetic steel plate and diamagnetic aluminium sheet.
As the preferred version of above-mentioned technology, described diamagnetic cylindrical pins, paramagnetic steel plate and strong permanent magnetic iron are crossed, it is fixed
Magnet, and be easily installed.
It is the entrance of crystallization plates placement as the preferred version of above-mentioned technology, described device portal, resists before device
The middle of magnetic aluminium sheet.
As the preferred version of above-mentioned technology, described entrance door closure, for blocking device entrance, strong magnetic in anti-locking apparatus
Environment ferromagnetic material is drawn, is produced dangerous.
It is as shown in figures 1 to 6 a kind of permanent magnetism enclosed experiment device appearance structural representation for crystallization of protein, fills
It is paramagnetic steel plate to put four faces up and down, and in front and back two sides is diamagnetic aluminium sheet, and the integrated connection of device is completed by paramagnetic lead screw,
It is connected firmly, device compact overall structure is firm.
As Fig. 2, Fig. 3, Fig. 4 and Fig. 5 show a kind of permanent magnetism enclosed experiment device internal structure for crystallization of protein
Schematic diagram, that is, device closed test system, the U-shaped diamagnetic aluminium for mainly having each two blocks strong permanent magnetic iron arranged side by side and centre up and down
Plate, is the rest area as crystallization in the U-shaped inner space of U-shaped aluminium sheet.
Preferably, the overall size of the experimental provision is 252*212*127mm, and spatial volume is little, so can be conveniently
Put into water bath with thermostatic control, carry out isothermal experiments.
Preferably, the thickness of four blocks of diamagnetic steel plates 1.2,1.7,2.1 and 2.5 is respectively 30mm, and material is q235
Steel, so substantially can all be enclosed in the magnetic line of force of permanent magnet in steel plate, and leakage field is few, considerably increase the examination of device inside
Test the magnetic field intensity and device overall structure its intensity in area.
Preferably, the diamagnetic aluminium sheet 1.6 and 3.1 is the duralumin plate of thickness 15mm, and aluminium sheet has diamagnetism, before and after device
The magnetic line of force can be avoided in the circulation short circuit of device surrounding using diamagnetic aluminium sheet, so as to the magnetic field intensity inside intensifier.
Preferably, the paramagnetic lead screw 1.3 and 1.4, material is paramagnetic steel material q235, and magnetic conduction effect is good, and intensity is big, even
Connect fastening.The a diameter of 8mm of big paramagnetic lead screw 1.3, for the overall structure of fixing device, little paramagnetic lead screw 1.4 is a diameter of
4mm, is mainly used in entrance door closure 1.5 being blocked into device portal 3.2 and being fixed on front diamagnetic aluminium sheet 1.6.
Preferably, the diamagnetic air space 2.4 is located between strong permanent magnetic iron and left and right paramagnetic steel plate, it is possible to reduce magnetic force
Line, directly through paramagnetic steel plate, reduces magnetic line of force loss from magnet both sides.
Preferably, the U-shaped aluminium sheet, is clipped between upper and lower strong permanent magnetic iron, and aluminium sheet is diamagnetic material, and the magnetic line of force is substantially not
Or seldom can pass through from U-shaped aluminium sheet, so make the magnetic line of force more concentrate on the U-shaped indentation, there of U-shaped aluminium sheet, increase crystallization
The magnetic field intensity of plate rest area.
Preferably, the specification of the strong permanent magnet 2.6,2.8,5.1 and 5.2 is 110*110*27.5mm, and remanent magnetism is 1.40
～1.44T, material is ndfeb magnet, and up and down distance is 18mm, and N-S the two poles of the earth are relative, so can as much as possible increase magnet
The magnetic field intensity at the two poles of the earth.
Preferably, the U-shaped aluminium sheet locating slot 6.1 is dug in left and right paramagnetic steel plate 1.7,2.2 and rear diamagnetic aluminium sheet 3.1
Portion, primarily serves restriction and the effect of the U-shaped aluminium sheet of fixation.
Preferably, the strong permanent magnetic iron locating slot 6.2 is dug in the middle part of upper and lower paramagnetic steel plate 2.1,2.5, width ratio strong permanent magnetic
Iron iron is slightly wide, plays a part of phase magnet.
After the design parameter and making material that the present invention relates to determines, first by finite element analysis software
ANSYS is simulated experimental analysis, and sunykatuib analysis result crystallization plates rest area is essentially stationary magnetic field, and field intensity is more than 1T.Dress
Put after completing, measured using magnetic field intensity measurement apparatus, the selected point result of measurement is similar to analog result, magnetic field
Intensity is consistent with desired design result in 1T or so.
Comprise the following steps when the present invention is used：
The first step, crystallization plates point sample.Crystallization of protein solution, point are added on crystallization plates, crystallization plates carry out relevant treatment.
Second step, crystallization plates are placed.The entrance door closure of apparatus of the present invention is removed with screwdriver, will be with liquid crystallization plates from dress
Flat propulsion plant at posting port, makes the crystallization plates rest area that crystallization plates are positioned over inside device.
3rd step, after device portal door closure is fixed, device is kept flat into circulator bath, thermostatical crystallization.
4th step, when need to observe crystallization effect, takes out crystallization plates, and basis of microscopic observation is taken pictures.
Claims (7)
1. a kind of permanent magnetism enclosed experiment device for crystallization of protein, including permanent magnet, U-shaped aluminium sheet, diamagnetic aluminium sheet and paramagnetic
Steel plate, it is characterised in that：Permanent magnet described in two pieces is placed in parallel, and the opposite polarity of two block permanent magnet correspondence positions；It is described
U-shaped aluminium sheet be located between two block permanent magnets, aluminium sheet and permanent magnet enclose that five bandings are closed, the crystallization plates of openings at one side are put
Put area；Some paramagnetic steel plates and diamagnetic aluminium sheet enclose an enclosed construction, permanent magnet and U-shaped aluminium sheet are wrapped in, it is described
Enclosed construction in, just diamagnetic aluminium sheet is to the both sides of U-shaped aluminium sheet opening.
2. the permanent magnetism enclosed experiment device for crystallization of protein according to claim 1, it is characterised in that：It is described forever
Magnet adopts neodymium iron boron strong permanent magnetic iron.
3. the permanent magnetism enclosed experiment device for crystallization of protein according to claim 1, it is characterised in that：Described U
Respectively there are two block permanent magnets type aluminium sheet both sides, and two block permanent magnets of the same side are generally aligned in the same plane and are adjacent to placement, and two block permanent magnets
The opposite polarity of adjacent side.
4. the permanent magnetism enclosed experiment device for crystallization of protein according to claim 1, it is characterised in that：It is described forever
Magnet leaves space in itself residing plane between enclosed construction.
5. the permanent magnetism enclosed experiment device for crystallization of protein according to claim 1, it is characterised in that：Described envelope
In closing structure, diamagnetic aluminium sheet is just provided with crystallization plates entrance to the position of U-shaped aluminium sheet opening, and is closed by door closure.
6. the permanent magnetism enclosed experiment device for crystallization of protein according to claim 1, it is characterised in that：Described is suitable
Magnetic steel plate is fastenedly connected by paramagnetic lead screw, and described diamagnetic aluminium sheet is arranged on paramagnetic steel plate by paramagnetic lead screw.
7. the permanent magnetism enclosed experiment device for crystallization of protein according to claim 1, it is characterised in that：It is described forever
Magnet is arranged on paramagnetic steel plate by magnetic cylindrical pins.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610898306.2A CN106644626B (en) | 2016-10-14 | 2016-10-14 | A kind of permanent magnetism enclosed experiment device for crystallization of protein |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610898306.2A CN106644626B (en) | 2016-10-14 | 2016-10-14 | A kind of permanent magnetism enclosed experiment device for crystallization of protein |
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| Publication Number | Publication Date |
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| CN106644626A true CN106644626A (en) | 2017-05-10 |
| CN106644626B CN106644626B (en) | 2019-05-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111999487A (en) * | 2020-08-25 | 2020-11-27 | 张洪涛 | Permanent magnet closed experimental device for protein crystallization |
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| US5908578A (en) * | 1995-12-07 | 1999-06-01 | Bridgestone Corporation | Bonded magnet-forming composition and magnet roller using the same |
| CN1466768A (en) * | 2001-08-24 | 2004-01-07 | �����ɷ� | Magnetically hard object and method for adjusting the direction and position of a magnetic vector |
| US20040004523A1 (en) * | 2001-11-30 | 2004-01-08 | Humphries David E. | High performance hybrid magnetic structure for biotechnology applications |
| CN103207232A (en) * | 2013-03-12 | 2013-07-17 | 西北工业大学 | Device for research on protein crystallization by periodic pulsating field |
| US20150135829A1 (en) * | 2012-06-14 | 2015-05-21 | Presidents And Fellows Of Harvard College | Levitation of Materials in Paramagnetic Ionic Liquids |
| CN105823662A (en) * | 2016-04-21 | 2016-08-03 | 天津宏华焊研机器人科技有限公司 | Magnetic treatment device with mixed magnetic field |
-
2016
- 2016-10-14 CN CN201610898306.2A patent/CN106644626B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5908578A (en) * | 1995-12-07 | 1999-06-01 | Bridgestone Corporation | Bonded magnet-forming composition and magnet roller using the same |
| CN1466768A (en) * | 2001-08-24 | 2004-01-07 | �����ɷ� | Magnetically hard object and method for adjusting the direction and position of a magnetic vector |
| US20040004523A1 (en) * | 2001-11-30 | 2004-01-08 | Humphries David E. | High performance hybrid magnetic structure for biotechnology applications |
| US20150135829A1 (en) * | 2012-06-14 | 2015-05-21 | Presidents And Fellows Of Harvard College | Levitation of Materials in Paramagnetic Ionic Liquids |
| CN103207232A (en) * | 2013-03-12 | 2013-07-17 | 西北工业大学 | Device for research on protein crystallization by periodic pulsating field |
| CN105823662A (en) * | 2016-04-21 | 2016-08-03 | 天津宏华焊研机器人科技有限公司 | Magnetic treatment device with mixed magnetic field |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111999487A (en) * | 2020-08-25 | 2020-11-27 | 张洪涛 | Permanent magnet closed experimental device for protein crystallization |
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