CN106630997A - 骨骼修复用复合生物陶瓷的制备方法 - Google Patents

骨骼修复用复合生物陶瓷的制备方法 Download PDF

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CN106630997A
CN106630997A CN201611012066.8A CN201611012066A CN106630997A CN 106630997 A CN106630997 A CN 106630997A CN 201611012066 A CN201611012066 A CN 201611012066A CN 106630997 A CN106630997 A CN 106630997A
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Abstract

本发明公开了一种骨骼修复用复合生物陶瓷的制备方法，涉及生物材料领域，由以下质量份数的各个组分制备而成：羟基磷灰石30‑50份、钛酸钠20‑40份、纳米氧化钛5‑10份、氧化锆3‑7份、氮化硼2‑6份、氧化铝5‑10份和纳米氧化锌2‑5份。一种羟基磷灰石/钛酸钠复合生物陶瓷的制备方法，制备步骤如下：(1)称量；(2)球磨；(3)冷压成型；(4)高温煅烧；(5)冷却。本发明提供的羟基磷灰石/钛酸钠复合生物陶瓷，是利用钛酸钠对羟基磷灰石生物活性的促进作用，进一步提高羟基磷灰石的生物性能。因此，本发明提供的羟基磷灰石/钛酸钠复合生物陶瓷具有较好的生物活性，是一种理想的骨骼修复替代材料。

Description

骨骼修复用复合生物陶瓷的制备方法
技术领域
本发明属于生物材料领域，特别涉及一种羟基磷灰石/钛酸钠复合生物陶瓷及该生物陶瓷的制备方法。
背景技术
随着材料科技的发展，生物材料因其对机体组织进行修复、替代与再生的特殊性能，已经成为当今生物医学领域重要的研究方向之一。生物硬组织代用材料最早是使用体骨、动物骨，后来发展到采用不锈钢和塑料，由于不锈钢存在溶析、腐蚀和疲劳问题，塑料存在稳定性差和强度低的问题。因此造成生物材料发展的瓶颈，生物陶瓷的出现，改善了现有替代材料的不足，因其诸多优势，因此，生物陶瓷具有了广阔的发展前景。
磷酸钙陶瓷(CPC)是生物活性陶瓷材料中的重要种类，目前研究和应用最多的是羟基磷灰石(HA)和磷酸三钙(TCP)。磷酸钙陶瓷含有CaO和P2O5两种成份，是构成人体硬组织的重要无机物质，植入人体后，其表面同人体组织可通过键的结合，达到完全亲和。其中，HA在组成和结构上与人骨和牙齿非常相似，HA能使骨细胞附着在其表面, 随着新骨的生长，这个连接地带逐渐萎缩，并且HA通过晶体外层成为骨的一部分, 新骨可以从HA 植入体与原骨结合处沿着植入体表面或内部贯通性孔隙攀附生长。HA生物活性陶瓷是典型生物活性陶瓷，植入体内后能与组织在界面上形成化学键性结合,具有较高的力学性能，在人体生理环境中可溶解性较低。
目前，人们对钛酸钠的研究相对较少，钛酸钠也是具备一定生物活性的物质之一，其在陶瓷领域已经有所发展，已有研究表明，钛酸钠对羟基磷灰石的生物活性具有促进作用。
发明内容
本发明解决的技术问题：针对上述不足，克服现有技术的缺陷，本发明的目的是提供一种羟基磷灰石/钛酸钠复合生物陶瓷及其制备方法。
本发明的技术方案：一种羟基磷灰石/钛酸钠复合生物陶瓷，由以下质量份数的各个组分制备而成：
羟基磷灰石30-50份、钛酸钠20-40份、纳米氧化钛5-10份、氧化锆3-7份、氮化硼2-6份、氧化铝5-10份和纳米氧化锌2-5份。
作为优选，各个组分的质量份数为：羟基磷灰石35-45份、钛酸钠25-36份、纳米氧化钛6-9份、氧化锆4-6份、氮化硼3-5份、氧化铝6-8份和纳米氧化锌3-4份。
作为优选，各个组分的质量份数为：羟基磷灰石42份、钛酸钠34份、纳米氧化钛8份、氧化锆5份、氮化硼4份、氧化铝7份和纳米氧化锌3份。
一种羟基磷灰石/钛酸钠复合生物陶瓷的制备方法，制备步骤如下：
（1）称量：准确称取各个组分；
（2）球磨：将各个组分混合在一起，放入球磨机进行研磨混合；
（3）冷压成型：将混合粉体进行冷压成型；
（4）粉体成型后放入模具中，进行高温煅烧，温度为1000℃-1400℃，压力300-800MPa，时间3-10h；
（5）煅烧之后，待冷却取出，即得到块状羟基磷灰石/钛酸钠复合生物陶瓷。
作为优选，步骤（4）中煅烧的温度为1150℃。
作为优选，步骤（4）中煅烧的压力为600MPa。
有益效果：本发明提供的羟基磷灰石/钛酸钠复合生物陶瓷，是利用钛酸钠对羟基磷灰石生物活性的促进作用，进一步提高羟基磷灰石的生物性能。钛酸钠和羟基磷灰石经高温煅烧之后，钛酸钠形态发生变化，在钛酸钠层之中含有钙离子，含有钙离子的钛酸钠层对羟基磷灰石的沉积具有更高的诱惑力，在人体内更加促进羟基磷灰石的形成。
因此，本发明提供的羟基磷灰石/钛酸钠复合生物陶瓷具有较好的生物活性，是一种理想的骨骼修复替代材料。
具体实施方式
为了进一步理解本发明，下面结合实施例对本发明优选实施方案进行描述，但是应当理解， 这些描述只是为进一步说明本发明的特征和优点，而不是对本发明权利要求的限制。
实施例 1：
一种羟基磷灰石/钛酸钠复合生物陶瓷，包括以下质量份数的各个组分：
羟基磷灰石50份、钛酸钠40份、纳米氧化钛10份、氧化锆7份、氮化硼6份、氧化铝10份和纳米氧化锌5份。
根据本发明提供的制备方法制备羟基磷灰石/钛酸钠复合生物陶瓷，步骤如下：
（1）称量：准确称取各个组分；
（2）球磨：将各个组分混合在一起，放入球磨机进行研磨混合；
（3）冷压成型：将混合粉体采用60T压机进行压制；
（4）粉体成型后放入模具中，进行高温煅烧，温度为1300℃，压力700MPa，时间4h；
（5）煅烧之后，待冷却取出，即得到块状羟基磷灰石/钛酸钠复合生物陶瓷。
对得到的块状羟基磷灰石/钛酸钠复合生物陶瓷进行检测，检测生物陶瓷的性能：硬度840HV；压缩强度1100MPa；抗弯强度420MPa；韧性16MPa·m1/2。
实施例 2：
一种羟基磷灰石/钛酸钠复合生物陶瓷，包括以下质量份数的各个组分：
羟基磷灰石30份、钛酸钠20份、纳米氧化钛5份、氧化锆3份、氮化硼2份、氧化铝5份和纳米氧化锌2份。
根据本发明提供的制备方法制备羟基磷灰石/钛酸钠复合生物陶瓷，步骤如下：
（1）称量：准确称取各个组分；
（2）球磨：将各个组分混合在一起，放入球磨机进行研磨混合；
（3）冷压成型：将混合粉体采用60T压机进行压制；
（4）粉体成型后放入模具中，进行高温煅烧，温度为1300℃，压力700MPa，时间7h；
（5）煅烧之后，待冷却取出，即得到块状羟基磷灰石/钛酸钠复合生物陶瓷。
对得到的块状羟基磷灰石/钛酸钠复合生物陶瓷进行检测，检测生物陶瓷的性能：硬度810HV；压缩强度1060MPa；抗弯强度400MPa；韧性14MPa·m1/2。
实施例 3：
一种羟基磷灰石/钛酸钠复合生物陶瓷，包括以下质量份数的各个组分：
羟基磷灰石35份、钛酸钠25份、纳米氧化钛6份、氧化锆4份、氮化硼3份、氧化铝6份和纳米氧化锌3份。
根据本发明提供的制备方法制备羟基磷灰石/钛酸钠复合生物陶瓷，步骤如下：
（1）称量：准确称取各个组分；
（2）球磨：将各个组分混合在一起，放入球磨机进行研磨混合；
（3）冷压成型：将混合粉体采用60T压机进行压制；
（4）粉体成型后放入模具中，进行高温煅烧，温度为1150℃，压力600MPa，时间6h；
（5）煅烧之后，待冷却取出，即得到块状羟基磷灰石/钛酸钠复合生物陶瓷。
对得到的块状羟基磷灰石/钛酸钠复合生物陶瓷进行检测，检测生物陶瓷的性能：硬度810HV；压缩强度1060MPa；抗弯强度400MPa；韧性14MPa·m1/2。
实施例4：
一种羟基磷灰石/钛酸钠复合生物陶瓷，包括以下质量份数的各个组分：
羟基磷灰石45份、钛酸钠36份、纳米氧化钛9份、氧化锆6份、氮化硼5份、氧化铝8份和纳米氧化锌4份。
根据本发明提供的制备方法制备羟基磷灰石/钛酸钠复合生物陶瓷，步骤如下：
（1）称量：准确称取各个组分；
（2）球磨：将各个组分混合在一起，放入球磨机进行研磨混合；
（3）冷压成型：将混合粉体采用60T压机进行压制；
（4）粉体成型后放入模具中，进行高温煅烧，温度为1150℃，压力600MPa，时间6h；
（5）煅烧之后，待冷却取出，即得到块状羟基磷灰石/钛酸钠复合生物陶瓷。
对得到的块状羟基磷灰石/钛酸钠复合生物陶瓷进行检测，检测生物陶瓷的性能：硬度820HV；压缩强度1080MPa；抗弯强度410MPa；韧性16MPa·m1/2。
实施例5：
一种羟基磷灰石/钛酸钠复合生物陶瓷，包括以下质量份数的各个组分：
羟基磷灰石42份、钛酸钠34份、纳米氧化钛8份、氧化锆5份、氮化硼4份、氧化铝7份和纳米氧化锌3份。
根据本发明提供的制备方法制备羟基磷灰石/钛酸钠复合生物陶瓷，步骤如下：
（1）称量：准确称取各个组分；
（2）球磨：将各个组分混合在一起，放入球磨机进行研磨混合；
（3）冷压成型：将混合粉体采用60T压机进行压制；
（4）粉体成型后放入模具中，进行高温煅烧，温度为1150℃，压力600MPa，时间5h；
（5）煅烧之后，待冷却取出，即得到块状羟基磷灰石/钛酸钠复合生物陶瓷。
对得到的块状羟基磷灰石/钛酸钠复合生物陶瓷进行检测，检测生物陶瓷的性能：硬度820HV；压缩强度1080MPa；抗弯强度420MPa；韧性16MPa·m1/2。
对所公开的实施例的上述说明，使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的，本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下，在其它实施例中实现。因此，本发明将不会被限制于本文所示的这些实施例，而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。

Claims (3)

1.一种羟基磷灰石/钛酸钠复合生物陶瓷的制备方法，其特征在于，该复合生物陶瓷由以下质量份数的各个组分制备而成：
羟基磷灰石35-45份、钛酸钠25-36份、纳米氧化钛6-9份、氧化锆4-6份、氮化硼3-5份、氧化铝6-8份和纳米氧化锌3-4份;
所述的制备方法，包括的制备步骤如下：
（1）称量：准确称取各个组分；
（2）球磨：将各个组分混合在一起，放入球磨机进行研磨混合；
（3）冷压成型：将混合粉体进行冷压成型；
（4）粉体成型后放入模具中，进行高温煅烧，温度为1000℃-1400℃，压力300-800MPa，时间3-10h；
（5）煅烧之后，待冷却取出，即得到块状羟基磷灰石/钛酸钠复合生物陶瓷。
2.根据权利要求1所述的羟基磷灰石/钛酸钠复合生物陶瓷的制备方法，其特征在于：步骤（4）中煅烧的温度为1150℃。
3.根据权利要求1所述的羟基磷灰石/钛酸钠复合生物陶瓷的制备方法，其特征在于：步骤（4）中煅烧的压力为600MPa。
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