CN106626424A - Printing head for biologic 3D printing - Google Patents
Printing head for biologic 3D printing Download PDFInfo
- Publication number
- CN106626424A CN106626424A CN201611215295.XA CN201611215295A CN106626424A CN 106626424 A CN106626424 A CN 106626424A CN 201611215295 A CN201611215295 A CN 201611215295A CN 106626424 A CN106626424 A CN 106626424A
- Authority
- CN
- China
- Prior art keywords
- closure
- biological
- hybrid chamber
- agitator
- printing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C67/00—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C67/00—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00
- B29C67/24—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00 characterised by the choice of material
- B29C67/246—Moulding high reactive monomers or prepolymers, e.g. by reaction injection moulding [RIM], liquid injection moulding [LIM]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y40/00—Auxiliary operations or equipment, e.g. for material handling
Abstract
The invention relates to a printing head for biologic 3D printing, which comprises a material mixing cavity mounted on a moving arm of a 3D printer, and a feeding port for feeding the material mixing cavity is arranged in the material mixing cavity; a discharging pipe is arranged in the material mixing cavity; a stirrer and a discharger are arranged in the material mixing cavity, wherein the stirrer is a rotary stirrer and comprises a rotary shaft and stirring bulges arranged on the rotary shaft, and after stirred and mixed by rotation of the stirrer, the material in the material mixing cavity is squeezed out from the discharging pipe through driving of the discharger. The printing head realizes synchronization of hardening and mixing of a biologic simulation material by the stirring hollow cavity with a mixing function.
Description
Technical field
The present invention relates to a kind of be used for biosimulation printing device field, in particular belong to a kind of biological 3D printing and print
Head.
Background technology
During traditional biological 3D printing, need that hydrogel or hydrogel-stem cell compound are pressurizeed, heat behaviour
Make, to reduce viscosity of material, realize extrusion, i.e. physical phase transition molding techniques.The present invention, will be aqueous gelled to solve this problem
Learn polymerisation be transferred in biological 3D printing printhead, original position is mixed and is induced reaction so that material flow through it is crowded
It is in low viscosity state during lifting one's head, using the holdup time control chemical reaction in extruder head so that material leaves extruder head
Enough high viscositys are reached during discharge gate, the shape of 3D printing design is kept.The biological 3D printing printhead that this patent is required
Designed based on biological enzyme cross-linking system.In the case of oxidant is present, biology enzyme can be by the height with phenol functional group
Molecule hydrogel monomer is polymerized, so as to realize the chemical polymerization phase transformation of hydrogel material.On this basis, it is possible to achieve other
The operation of multicomponent reaction cross-linking system.
The content of the invention
The technical problem to be solved in the present invention is：Overcome technical problem of the prior art, there is provided a kind of biological 3D printing
Use printhead.
The technical solution adopted for the present invention to solve the technical problems is：
A kind of biological 3D printing printhead, including the material hybrid chamber on 3D printer transfer arm, in material mixing
It is provided with chamber for the inlet of material hybrid chamber feed；Drainage conduit is provided with the material hybrid chamber, in material
It is provided with agitator and removal device in hybrid chamber, wherein agitator is rotary agitator, including rotary shaft and is arranged on rotation
Stir raised on axle, after the material in material hybrid chamber is via the Stirring mixing of agitator, by the driving of removal device,
Extrude from drainage conduit.
As a further improvement on the present invention, the removal device is structure as a whole with agitator, and the agitator is spiral
Formula agitator, the stirring is raised to be included arranging spiral prominence playing piece on the rotary shaft, and the one end part of rotary shaft is mixed in material
The drainage conduit link position in chamber is closed, the material in material hybrid chamber under the pushing of spiral prominence playing piece, simultaneously from drainage conduit arrange by mixing
Go out.
As a further improvement on the present invention, the material hybrid chamber includes a closure,
As a further improvement on the present invention, the inlet includes some conversion seats being arranged on closure wall, institute
Conversion seat is stated through closure wall, a joint fixing hole for connecting pipe joint is provided with conversion seat.
As a further improvement on the present invention, the closure is closing tubbiness, and wherein drainage conduit is connected to outside closing
Axial one end of shell, in the axial other end of closure an opening is provided with, and a closing is provided with over said opening
End cap, rotates connection between the rotary shaft and closed end cap.
As a further improvement on the present invention, the edge of the closed end cap is provided with an annular flange, rotary shaft
By a driving stepper motor, the motor housing of stepper motor is fixed on closed end cap by aforesaid annular flange.
As a further improvement on the present invention, the outer wall in closure is additionally provided with a heating jacket, in heating folder
The heating cavities of an annular are provided with set, the heating cavities are connected with thermal fluid circulation, follow by transfer tube and pipeline
Septate heat transfer is carried out between material inside ring hot fluid and closure.
As a further improvement on the present invention, the drainage conduit is screw needle tubular construction, and it includes a hollow discharge
Pin and the gland for being fixed on discharge needle end part, in the end of the closure connecting seat, the connecting seat are provided with
It is threaded connection between gland.
As a further improvement on the present invention, the connecting seat includes an adapter sleeve, fixes in the end of closure
There is a connection ring, be threaded connection between connection ring and adapter sleeve, being fixedly arranged in the middle of for fixed in adapter sleeve
The connecting tube of head.
As a further improvement on the present invention, the closure is made using stainless steel.
The invention has the beneficial effects as follows：
1st, the present invention realizes the synchronization to the mixing of biological simulacrumy material, hardening by a stirring cavity with mixed function
Carry out.Avoid the heating in classic screw extrusion, the potential impact that pressure process is caused to stem cell, while mixing
The chemical reaction of generation, can reach exit and complete polymerisation in fluid, so as to avoid high pressure, high temperature ring in extruder head
Border, realizes chemical reaction plastotype.
2nd, the agitator and removal device of integrative-structure optimizes structure, compared to air pressure material extrusion, the method for stirring rod spice
For, the pressure of closure is relatively low in this structure, it is not easy to leak；Compared to compressible gas, the row of this structure
Material speed can be controlled by controlling the speed of rotation of spiral prominence playing piece, and controllability is higher；And this structure can be by
It is completely exhausted out after material stirring, is not easy the presence of stirring dead angle compared to poking bar.
3rd, conversion seat can facilitate the screw-type connection of all kinds of joints, connect for pipeline compared to installing additional on closure
The screwed hole of head dismounting, conversion seat can realize the switching of pipe joint, reduce the utilization rate of closure upper screwed hole, improve
The life-span of closure.
4th, rotating seat undertakes screw rod and fixes and sealing task, can stablize screw rod and rotate the vibrations for causing, and isolates motor
Part and material bin, realize the requirement of environment asepticization in shell.
5th, the closure of this structure is the end cover structure that can be turned on and off, and greatly facilitates and closure is torn open
Unload the cleaning with internal part.
6th, the flange arrangement being arranged on end cap facilitates the stable fixation of motor, it is ensured that motor is same with closure
Step connection, shake when will not rotate because of motor causes rotary shaft opposing compression to occur with closure and causes rotary shaft
Deformation, the jitter rate of printhead, improves print quality during so as to reducing printing.
7th, the heating jacket of external is compared to built-in heat pipes heat, and heat exchange efficiency is high, and will not be outer to closing
The band of shell inner space and closure is affecting.
8th, this printhead using medical needle tube type discharging structure, the connected mode of screw thread is easy to disassemble and changes.
9th, the present invention is transferred by adapter sleeve, being directly connected to compared to needle tubing, and it is outer that this structure can expand closing
The opening size of shell end, is easy to the cleaning of closure；And exchanging structure can improve closure compared to direct-connected
Life-span.
Description of the drawings
With reference to the accompanying drawings and examples the present invention is further described.
Fig. 1 is the generalized section of printhead；
Fig. 2 is the partial enlarged drawing in Fig. 1 at A；
Fig. 3 is the assembling schematic diagram of printhead motor.
In figure：1st, closure；2nd, rotary shaft；3rd, threaded bosses；4th, closed end cap；5th, rotating seat；6th, conversion seat；7th, even
Connect ring；8th, adapter sleeve；9th, connecting tube；10th, gland；11st, discharge needle；12nd, heating jacket；13rd, water inlet；14th, motor housing；
15th, shaft coupling；16th, stepper motor.
Specific embodiment
In conjunction with the accompanying drawings, the present invention is further detailed explanation.These accompanying drawings are simplified schematic diagram, only with
The basic structure of the illustration explanation present invention, therefore it only shows the composition relevant with the present invention.
As shown in figure 1, the present invention is a kind of biological 3D printing printhead, its main body is outside the closing of a cylindrical shape
Shell, in axial one end of closure the discharge chamber of a gradually-reducing shape is provided with, and is arranged on the axial other end of closure
There is a closed end cap；A material hybrid chamber is constituted in closure, the mixing to printing material is realized, and by discharge chamber
Discharge, closed end cap can be fixed on closure using flange or helicitic texture.
In order to realize the purpose of stirring, the screw mixing of stirring and discharge functions is provided with closure
Device, its main body rotates the rotary shaft being connected including one between closed end cap, and in closed end cap a rotation is fixedly arranged in the middle of
Seat, rotating seat is rotated with rotary shaft by sealed bearings and is connected, and rotary shaft is synchronous with closure fixed, and wherein one end extends
To the necking end in discharge chamber, the threaded bosses of sequential like are provided with the rotary shaft, the radius of fillet of its threaded bosses can be with root
Set according to concrete operating mode, its concrete operating mode will mainly refer to the viscosity of material, and the material larger for viscosity can be by subtracting
Minor thread radius is reducing its friction area；Then there is stirring mixing by the rotation of threaded bosses in material, and in screw thread
Discharged by discharge chamber under pushing.The speed of screw rod rotation is determined that high reaction rate is printed to be needed by the speed that hydrogel polymeric reacts
The short holdup time is wanted, i.e. higher baseline speed, vice versa.
In order to control quality, general charging shear modulus G ' in 20 Pa once, extruded stock shear modulus G ' can reach
200-10000 Pa.
As shown in Fig. 2 being coaxially fixed with a connection ring on the end in discharge chamber, a company is threaded connection in connection ring
Joint chair, connecting seat includes the tubular adapter sleeve of an one end open, and the inwall of adapter sleeve is fixedly connected with connection ring；Simultaneously even
The blind end middle part of female connector is provided with a connecting tube, and medical stainless steel needle tubing has been threaded connection in connecting tube；Wherein connect
The adapter sleeve profile of joint chair can be set to straight tube or bending tubular according to different operating modes；
Medical stainless steel needle tubing includes hollow discharge needle and is fixed on the gland of discharge needle end part, gland be connected
It is threaded connection between pipe.
As shown in figure 1, being further fixed on a heating jacket in the outside of closure, one is provided with heating jacket
The heating cavities of annular, in heating jacket outer wall a water inlet and a discharge outlet are provided with, and are completely cut off with materials inside cabin,
Ensure the gnotobasis in materials inside cabin.Water inlet and discharge outlet are connected to a water and heat on bucket by a transfer tube, lead to
Pump overdrive so that heat exchange of the hot water between heating jacket internal circulation flow, realization and closure.
Some inlets are additionally provided with the outer wall of closure, the position of inlet and bore are according to according to concrete material
Quantity and characteristic be configured, inlet includes some conversion seats being arranged on closure wall, and the conversion seat passes through
Chuanfeng closes shell wall, and a joint fixing hole for connecting pipe joint is provided with conversion seat；The feed of material is then
Feed is carried out by the connecting tube being connected on aforementioned adapter, then easily can be dismantled by rotation during dismounting, this
Can be with the snap joint of more prefabricated such as pagoda joint etc, to realize the fast assembling-disassembling of pipeline on external conversion seat.
In order to ensure the parts such as certain gnotobasis, closure, closed end cap, spiral agitator using stainless
Steel is made.
Such as Fig. 1 and Fig. 3, in closed end cap periphery an annular flange is additionally provided with, rotary shaft by a shaft coupling with
Stepper motor is connected, and the motor housing of stepper motor is fixed on closed end cap by aforesaid annular flange；In order to drop
Low vibration can be attached using Hooks coupling universal coupling.
When specifically used：With superoxide dismutase（HRP）/ hydrogen peroxide（H2O2）As a example by cross-linking system, wherein peroxidating
Thing mutase（HRP）Inlet be located at closure top near closed end cap position, and hydrogen peroxide（H2O2）Inlet
Closure bottom is then located near discharge chamber position；Both are squeezed in closed cavity by certain material extrusion pump, and are passed through
Spiral agitator is stirred so that superoxide dismutase（HRP）And hydrogen peroxide（H2O2）Occur in discharge empty cavity position mixed
Close, while discharging via discharge needle, realize aforementioned two raw material crosslinking condense, its setting time by discharge velocity control,
Specific governing factor includes screw rod rotary speed, flight pitch, length of discharge needle etc.；The intensity of gel can pass through feed
The rotating speed of proportioning and same control rotary shaft, is controlled.
With the above-mentioned desirable embodiment according to the present invention as enlightenment, by above-mentioned description, relevant staff is complete
Entirely various change and modification can be carried out in the range of without departing from this invention technological thought.The technology of this invention
Property scope is not limited to the content on specification, it is necessary to its technical scope is determined according to right.
Claims (10)
1. a kind of biological 3D printing printhead, is characterized in that：Including the material hybrid chamber on 3D printer transfer arm,
It is provided with material hybrid chamber for the inlet of material hybrid chamber feed；Discharge is provided with the material hybrid chamber
Pipe, is provided with agitator and removal device in material hybrid chamber, and wherein agitator is rotary agitator, including rotary shaft and sets
Put and stir on the rotary shaft raised, after the material in material hybrid chamber is via the Stirring mixing of agitator, by discharge
The driving of device, extrudes from drainage conduit.
2. a kind of biological 3D printing printhead as claimed in claim 1, is characterized in that：The removal device is one with agitator
Body structure, the agitator is spiral agitator, and the stirring is raised to be included arranging spiral prominence playing piece on the rotary shaft, rotation
The one end part of rotating shaft is pushed away in the drainage conduit link position of material hybrid chamber, the material in material hybrid chamber spiral prominence playing piece
Force down, mixing is simultaneously discharged from drainage conduit.
3. a kind of biological 3D printing printhead as claimed in claim 1, is characterized in that：The material hybrid chamber includes one
Closure.
4. a kind of biological 3D printing printhead as claimed in claim 3, is characterized in that：The inlet includes some settings
Conversion seat on closure wall, the conversion seat runs through closure wall, and one is provided with conversion seat is used for
The joint fixing hole of connecting pipe joint.
5. a kind of biological 3D printing printhead as claimed in claim 3, is characterized in that：The closure is closed vat
Shape, wherein drainage conduit are connected to axial one end of closure, and the axial other end of closure is provided with an opening,
A closed end cap is provided with the opening, connection is rotated between the rotary shaft and closed end cap.
6. a kind of biological 3D printing printhead as claimed in claim 5, is characterized in that：Set at the edge of the closed end cap
An annular flange is equipped with, by a driving stepper motor, the motor housing of stepper motor is by aforesaid annular for rotary shaft
Flange is fixed on closed end cap.
7. a kind of biological 3D printing printhead as claimed in claim 3, is characterized in that：Also set up in the outer wall of closure
Have a heating jacket, be provided with the heating cavities of an annular in heating jacket, the heating cavities by transfer tube and
Pipeline is connected with thermal fluid circulation, and septate heat transfer is carried out between the material inside thermal fluid circulation and closure.
8. a kind of biological 3D printing printhead as claimed in claim 3, is characterized in that：The drainage conduit is screw thread needle tubing knot
Structure, it includes a hollow discharge needle and is fixed on the gland of discharge needle end part, arranges in the end of the closure
There is a connecting seat, be threaded connection between the connecting seat and gland.
9. a kind of biological 3D printing printhead as claimed in claim 8, is characterized in that：The connecting seat includes a connection
Set, in the end of closure a connection ring is fixed with, and is threaded connection between connection ring and adapter sleeve, in adapter sleeve
It is fixedly arranged in the middle of the connecting tube for fixing gland.
10. a kind of biological 3D printing printhead as claimed in claim 3, is characterized in that：The closure is using stainless
Steel is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611215295.XA CN106626424A (en) | 2016-12-26 | 2016-12-26 | Printing head for biologic 3D printing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611215295.XA CN106626424A (en) | 2016-12-26 | 2016-12-26 | Printing head for biologic 3D printing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106626424A true CN106626424A (en) | 2017-05-10 |
Family
ID=58828065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611215295.XA Pending CN106626424A (en) | 2016-12-26 | 2016-12-26 | Printing head for biologic 3D printing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106626424A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107214956A (en) * | 2017-05-16 | 2017-09-29 | 武汉理工大学 | A kind of utilization PET material is the 3D printing shower nozzle of shape wire |
| CN109703021A (en) * | 2019-01-09 | 2019-05-03 | 厦门大学 | A kind of more material hybrid nozzles |
| KR101981115B1 (en) * | 2017-11-15 | 2019-05-22 | 울산과학기술원 | Drone type 3D printer using a wired system |
| CN112497422A (en) * | 2020-11-18 | 2021-03-16 | 康硕(德阳)智能制造有限公司 | Special feeding mechanism of pottery 3D printer |
| CN112677282A (en) * | 2020-12-02 | 2021-04-20 | 同济大学 | Concrete 3D beats printer head and printing apparatus |
| WO2021136297A1 (en) * | 2019-12-30 | 2021-07-08 | 四川蓝光英诺生物科技股份有限公司 | Bioprinter nozzle, bioprinter and method for printing luminal tissue construct |
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| CN104626556A (en) * | 2013-11-12 | 2015-05-20 | 华中科技大学 | Fused deposition three dimensional printing nozzle and printer |
| KR20160120031A (en) * | 2015-04-07 | 2016-10-17 | 홍국선 | Multiple materials mixing melt extruder and 3D printer using it |
| CN206357665U (en) * | 2016-12-26 | 2017-07-28 | 常州清大智造科技有限公司 | A kind of biological 3D printing printhead |
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| CN104626556A (en) * | 2013-11-12 | 2015-05-20 | 华中科技大学 | Fused deposition three dimensional printing nozzle and printer |
| CN103862678A (en) * | 2014-03-19 | 2014-06-18 | 昆山博力迈三维打印科技有限公司 | 3D printer made of curing material with reaction of multiple components |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107214956A (en) * | 2017-05-16 | 2017-09-29 | 武汉理工大学 | A kind of utilization PET material is the 3D printing shower nozzle of shape wire |
| KR101981115B1 (en) * | 2017-11-15 | 2019-05-22 | 울산과학기술원 | Drone type 3D printer using a wired system |
| CN109703021A (en) * | 2019-01-09 | 2019-05-03 | 厦门大学 | A kind of more material hybrid nozzles |
| WO2021136297A1 (en) * | 2019-12-30 | 2021-07-08 | 四川蓝光英诺生物科技股份有限公司 | Bioprinter nozzle, bioprinter and method for printing luminal tissue construct |
| CN112497422A (en) * | 2020-11-18 | 2021-03-16 | 康硕(德阳)智能制造有限公司 | Special feeding mechanism of pottery 3D printer |
| CN112677282A (en) * | 2020-12-02 | 2021-04-20 | 同济大学 | Concrete 3D beats printer head and printing apparatus |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170510 |
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| RJ01 | Rejection of invention patent application after publication |