CN106620094A - Preparation method of medicinal liquor for treating rheumatic pain - Google Patents

Preparation method of medicinal liquor for treating rheumatic pain Download PDF

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CN106620094A
CN106620094A CN201611163891.8A CN201611163891A CN106620094A CN 106620094 A CN106620094 A CN 106620094A CN 201611163891 A CN201611163891 A CN 201611163891A CN 106620094 A CN106620094 A CN 106620094A
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medicinal liquor
ethanol
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treating rheumatic
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贺文娟
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/648—Myriapods, e.g. centipedes or millipedes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884—Arisaema, e.g. Jack in the pulpit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a preparation method of medicinal liquor for treating rheumatic pain. The preparation method includes steps of (1), weighing components by mass: 5-10 parts of corn cervi pantotrichum, 10-15 parts of rhodiola rosea, 5-10 parts of pepper, 10-15 parts of safflower carthamus, 8-12 parts of rhizoma corydalis, 8-10 parts of fraxinus bungeana, 12-15 parts of jasmine, 8-10 parts of scorpio, 10-15 parts of borneol, 5-8 parts of musk, 5-10 parts of Chinese lizardtail rhizome, 8-10 parts of centipede, 8-12 parts of arisaema rhizomatum, and 12-15 parts of folium artemisiae argyi; (2), smashing and mixing, immersing and cooking components by millet wine; (3), extracting the filtering slag by ethanol; (4), combining the extracting agent and the decocta; mixing the extracting agent with ethanol with volume ratio of 1: 1-1.5; (5), adding 1-1.2% of methyl salicylate, 1-1.5% of turpentine oil, 0.2-0.3% of aminopyrine, and 0.2-0.3% of phenacetin in the raw fluid of the medicinal liquor. The drug can treat both symptoms and root causes, convenient to use, free from toxic and side effects, fast in effect and not easy to relapse.

Description

A kind of preparation method of the medicinal liquor for treating treating rheumatic ostealgia
Technical field
The present invention relates to treat the medicine for the treatment of rheumatic ostealgia, and in particular to a kind of preparation side of the medicinal liquor for treating treating rheumatic ostealgia Method.
Background technology
Treating rheumatic ostealgia is a kind of chronic disease, and major lesions are respectively organized for joint, such as periosteum, cartilage, muscle, and the disease is Frequently-occurring disease, the lighter's painful swelling of joints, severe one muscular atrophy brings serious puzzlement to patient.
At present, mostly using the method for medicine for oral administration come symptom management, but after patient's long-term taking, stomach often occurs not The toxic and side effect such as suitable, and also increase the psychological burden of patient.
It is undesirable in order to solve existing Chinese medicine effect when treating rheumatic ostealgia is treated, and have certain sense of discomfort and side effect Problem, the present invention have developed it is a kind of can direct spraying external application externally applied drug.
The content of the invention
It is an object of the invention to provide a kind of preparation method of the medicinal liquor for treating treating rheumatic ostealgia.
The present invention is achieved by the following technical solutions：
A kind of preparation method of the medicinal liquor for treating treating rheumatic ostealgia, step is：
（1）Accurately weigh each component of following mass parts：Pilose antler 5-10, rhodiola root 10-15, Chinese prickly ash 5-10, safflower 10-15, prolong Hu rope 8-12, bark of ash 8-10, cape jasmine 12-15, scorpio 8-10, borneol 10-15, Moschus 5-8, Chinese lizardtail rhizome 5-10, centipede 8-10, Rootstock jackinthepulpit tuber 8-12, tarragon 12-15；
（2）Above-mentioned each component is pulverized and mixed, yellow rice wine immersion is decocted 20 minutes, is filtrated to get filter residue and decoction；
（3）By alcohol steep that filter residue mass concentration is 50-60% 3 times, leaching liquor is collected；
（4）Merge leaching liquor and decoction obtains extract, be 1 by extract and volume ratio:The ethanol of 1-1.5 is mixed to get medicinal liquor Stoste, described ethanol is the ethanol that mass concentration is 50-60%；
（5）Add gaultherolin, the turpentine oil of 1-1.5% of the medicinal liquor stoste volume than 1-1.2%, 0.2- in medicinal liquor stoste 0.3% aminopyrine, the phenacetin of 0.2-0.3%, then add stabilizer, obtain final product.
Further, gaultherolin, 1.2% turpentine of the medicinal liquor stoste volume than 1% is added in described medicinal liquor stoste Oil, 0.2% aminopyrine, 0.2% phenacetin.
Using method：Dip the medicinal liquor of the present invention, erasing affected part with disinfecting cotton swab daily, and gently rub affected part to skin Heating stops, daily erasing 3-4 time, and there are positive effect in general 2-3 weeks.
Medicinal liquor of the present invention is obtained using specific formula according to specific preparation method, in preparation process, first by each group With decocting after yellow rice wine immersion after point crushing, collect decocting liquid and filter residue, will merge with decocting liquid after filter residue alcohol steep, then with ethanol Add oil phase gaultherolin and turpentine oil after mixing, and add aminopyrine and phenacetin；Of the invention combination collaboration is matched somebody with somebody Close, and after being decocted with yellow rice wine immersion, can strengthen relax the muscles and stimulate the blood circulation, wines used as antirheumatic, the effect of alleviating ostalgia, and further add oil phase With aminopyrine and phenacetin, strengthen analgesic effect.
Using the medicine as obtained by the inventive method, therapeutic test is carried out to treating rheumatic ostealgia patient：
First, case：Spondylodynia 20, scapulohumeral periarthritis 25, lumbar vertebra disease 15, gonitis 30, rheumatism 10；
2nd, treatment method：Dip the medicinal liquor of the present invention, erasing affected part with disinfecting cotton swab daily, and gently rub affected part to skin Heating stops, daily erasing 3-4 time；
3rd, the course for the treatment of：It was a course for the treatment of per 2 weeks, is counted after 3 courses for the treatment of；
4th, data statistics：Through the test of 3 courses for the treatment of, wherein cure rate can reach 96%, and efficient is 100%.
Medicine of the present invention is treated both principal and secondary aspect of disease, easy to use, is had no toxic side effect, rapid-action, is difficult recurrence.
Specific embodiment
With reference to embodiment, the invention will be further described.
Embodiment 1
A kind of preparation method of the medicinal liquor for treating treating rheumatic ostealgia, step is：
（1）Accurately weigh each component of following mass parts：Pilose antler 5, rhodiola root 15, Chinese prickly ash 5, safflower 15, corydalis tuber 8, bark of ash 10, Cape jasmine 12, scorpio 10, borneol 10, Moschus 8, Chinese lizardtail rhizome 5, centipede 10, rootstock jackinthepulpit tuber 8, tarragon 15；
（2）Above-mentioned each component is pulverized and mixed, yellow rice wine immersion is decocted 20 minutes, is filtrated to get filter residue and decoction；
（3）By alcohol steep that filter residue mass concentration is 50-60% 3 times, leaching liquor is collected；
（4）Merge leaching liquor and decoction obtains extract, be 1 by extract and volume ratio:It is former that 1.5 ethanol is mixed to get medicinal liquor Liquid, described ethanol is the ethanol that mass concentration is 50-60%；
（5）Add gaultherolin, 1.5% turpentine oil of the medicinal liquor stoste volume than 1.1%, 0.3% ammonia in medicinal liquor stoste Ji Bilin, 0.2% phenacetin, then add stabilizer, obtain final product.
Embodiment 2
A kind of preparation method of the medicinal liquor for treating treating rheumatic ostealgia, step is：
（1）Accurately weigh each component of following mass parts：Pilose antler 10, rhodiola root 10, Chinese prickly ash 10, safflower 10, corydalis tuber 12, bark of ash 8th, cape jasmine 15, scorpio 8, borneol 15, Moschus 5, Chinese lizardtail rhizome 10, centipede 8, rootstock jackinthepulpit tuber 12, tarragon 12；
（2）Above-mentioned each component is pulverized and mixed, yellow rice wine immersion is decocted 20 minutes, is filtrated to get filter residue and decoction；
（3）By alcohol steep that filter residue mass concentration is 50-60% 3 times, leaching liquor is collected；
（4）Merge leaching liquor and decoction obtains extract, be 1 by extract and volume ratio:1.5 ethanol is mixed to get medicinal liquor Stoste, described ethanol is the ethanol that mass concentration is 50-60%；
（5）Add gaultherolin, 1% turpentine oil of the medicinal liquor stoste volume than 1.2%, 0.2% amino ratio in medicinal liquor stoste Woods, 0.3% phenacetin, then add stabilizer, obtain final product.
Embodiment 2
A kind of preparation method of the medicinal liquor for treating treating rheumatic ostealgia, step is：
（1）Accurately weigh each component of following mass parts：Pilose antler 8, rhodiola root 12, Chinese prickly ash 9, safflower 13, corydalis tuber 8-1210, the Qin Macrophylla 9, cape jasmine 13, scorpio 9, borneol 13, Moschus 7, Chinese lizardtail rhizome 8, centipede 9, rootstock jackinthepulpit tuber 10, tarragon 14；
（2）Above-mentioned each component is pulverized and mixed, yellow rice wine immersion is decocted 20 minutes, is filtrated to get filter residue and decoction；
（3）By alcohol steep that filter residue mass concentration is 50-60% 3 times, leaching liquor is collected；
（4）Merge leaching liquor and decoction obtains extract, be 1 by extract and volume ratio:It is former that 1 ethanol is mixed to get medicinal liquor Liquid, described ethanol is the ethanol that mass concentration is 50-60%；
（5）Add gaultherolin, 1.2% turpentine oil of the medicinal liquor stoste volume than 1%, 0.2% amino ratio in medicinal liquor stoste Woods, 0.2% phenacetin, then add stabilizer, obtain final product.

Claims (2)

1. a kind of preparation method of the medicinal liquor for treating treating rheumatic ostealgia, it is characterised in that step is：
（1）Accurately weigh each component of following mass parts：Pilose antler 5-10, rhodiola root 10-15, Chinese prickly ash 5-10, safflower 10-15, prolong Hu rope 8-12, bark of ash 8-10, cape jasmine 12-15, scorpio 8-10, borneol 10-15, Moschus 5-8, Chinese lizardtail rhizome 5-10, centipede 8-10, Rootstock jackinthepulpit tuber 8-12, tarragon 12-15；
（2）Above-mentioned each component is pulverized and mixed, yellow rice wine immersion is decocted 20 minutes, is filtrated to get filter residue and decoction；
（3）By alcohol steep that filter residue mass concentration is 50-60% 3 times, leaching liquor is collected；
（4）Merge leaching liquor and decoction obtains extract, be 1 by extract and volume ratio:The ethanol of 1-1.5 is mixed to get medicinal liquor Stoste, described ethanol is the ethanol that mass concentration is 50-60%；
（5）Add gaultherolin, the turpentine oil of 1-1.5% of the medicinal liquor stoste volume than 1-1.2%, 0.2- in medicinal liquor stoste 0.3% aminopyrine, the phenacetin of 0.2-0.3%, then add stabilizer, obtain final product.
2. the preparation method of the medicinal liquor for the treatment of treating rheumatic ostealgia according to claim 1, it is characterised in that described medicinal liquor is former Add gaultherolin, 1.2% turpentine oil of the medicinal liquor stoste volume than 1%, 0.2% aminopyrine, 0.2% Fei Naxi in liquid Fourth.
CN201611163891.8A 2016-12-16 2016-12-16 Preparation method of medicinal liquor for treating rheumatic pain Pending CN106620094A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110279782A (en) * 2019-07-03 2019-09-27 云南中医药大学 A kind of acupuncture auxiliary agent and its preparation and application method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1569146A (en) * 2004-04-27 2005-01-26 陈明元 Hippocampi contained transdermal plaster for treating contusions and strains and its preparation
CN1663599A (en) * 2005-02-05 2005-09-07 锦州市紫荆山制药厂 Improved plaster for treating rheumatic and rheumatoid diseases and preparation method thereof
CN104491767A (en) * 2014-08-18 2015-04-08 李学尧 Chinese medicinal composition for relieving pain and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1569146A (en) * 2004-04-27 2005-01-26 陈明元 Hippocampi contained transdermal plaster for treating contusions and strains and its preparation
CN1663599A (en) * 2005-02-05 2005-09-07 锦州市紫荆山制药厂 Improved plaster for treating rheumatic and rheumatoid diseases and preparation method thereof
CN104491767A (en) * 2014-08-18 2015-04-08 李学尧 Chinese medicinal composition for relieving pain and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110279782A (en) * 2019-07-03 2019-09-27 云南中医药大学 A kind of acupuncture auxiliary agent and its preparation and application method

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