CN104208324A - External medicine for treating gall caused by gout, rheumatism and rheumatoid arthritis and preparation method thereof - Google Patents
External medicine for treating gall caused by gout, rheumatism and rheumatoid arthritis and preparation method thereof Download PDFInfo
- Publication number
- CN104208324A CN104208324A CN201410462242.2A CN201410462242A CN104208324A CN 104208324 A CN104208324 A CN 104208324A CN 201410462242 A CN201410462242 A CN 201410462242A CN 104208324 A CN104208324 A CN 104208324A
- Authority
- CN
- China
- Prior art keywords
- radix
- rheumatoid arthritis
- rhizoma
- gout
- refers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an external medicine for treating gall caused by gout, rheumatism and rheumatoid arthritis and a preparation method thereof. The external medicine comprises the following medicinal raw materials in the optimum mass ratio: 90g of radix aconiti kusenzoffii, 90g of radix aconite, 90g of nux vomica, 90g of thunder god vine, 80g of notopterygium root, 80g of radix angelicae pubescentis, 60g of ephedra, 80g of cassia twig, 60g of asarum produced from Liaoning Province, 90g of radix clematidis, 80g of rhizoma atractylodis, 80g of phellodendron chinense schneid, 60g of pepper, 80g of short-pedicel aconite root, 80g of angelica, 90g of ligusticum wallichii, 60g of pedate pinallia jackinthepulpit rhizome, 80g of fructus broussonetiae, 60g of scorpion, 40g of centipede, 80g of ground beetle, 80g of frankincense, 80g of myrrh, 90g of medicinal cyathula root and 80g of borneol. The invention discloses a preparation method of an external tincture for treating gall caused by gout and rheumatism and rheumatoid arthritis, wherein the preparation method comprises technological processes of weighing on the medicinal raw materials according to the optimum mass ratio, putting into a container, soaking in alcohol, filtering, processing dregs, precipitating and bottling. The external medicine disclosed by the invention is obvious in efficacy, and the effective ratio of relieving swelling and pain is high up to 95%; and the external medicine is free from drug dependence, convenient to carry and use, low in cost and simple in production process.
Description
Technical field
The invention belongs to the technical field for the treatment of gout, rheumatism rheumatoid arthritis medicine, particularly relate to one and treat gout, rheumatism rheumatoid arthritis and to swell and ache topical agent and preparation method.
Background technology
The name of gout starts from gold dollar, Yuan Dynasty's ZHU Dan-xi " Further Discourses on the Properties of Things gout opinion " cloud: " gout person, extremity hundred save pain, and the severe and migratory arthralgia wind card of square book meaning is also." thereafter the ancestor such as Ming Dynasty's Sun Yikui, ZHANG Jie bin, clear just YU Jia-yan its say.Many gout being included in arthromyodynia or severe and migratory arthralgia of modern Chinese medicine internal medicine works is discussed.
The etiology and pathogenesis of gout invades human body in an opponent's defence by the heresy of six climate exopathogens, it is sweet suety greasy that patient throws off restraint food, cause organism metabolism malfunction, the pathological products such as wind and cold, damp and hot, expectorant is turbid, blood stasis are detained skin, meridians, muscles and bones, joint, cause coagulation of QI-blood obstructed and send out as gout.
Western medicine is thought: gout is a kind of fast cold metabolism disorder, causes uric acid concentration in blood too high, and the pathological changes caused by deposition.Clinical common acute, recurrent exerbation gouty arthritis, tophaceous deposition, Renal lesion, urate calculus is formed as feature.
Primary disease becomes main manifestations with osteoarthritis, belongs to traditional Chinese medical science arthromyodynia, severe and migratory arthralgia syndrome caused by wind pathogen category.Acute stage, is characterized as: onset is hurried, and how in midnight or outbreak in early morning, from the beginning of multiple single arthralgia, about half is sufficient thumb root joint, and secondly ankle, heel, knee joint, wrist, elbow, articulations digitorum manus are got involved, and joint is red, swollen, hot, bitterly.Chronic phase arthroncus, stiff, lopsided, have a strong impact on limb function activity, even lose life, ability to work.
Rheumatalgia, ancient claims " arthromyodynia ", be more common in arduous labor do or puerperal, large body void after being ill people, do not avoid air-cooled water and wet, the heresy of six climate exopathogens invades health in an opponent's defence, causes skin, meridians, blood vessels, muscles and bones mechanism of qi stagnates inaccessible obstructed, and to send out be various arthromyodynia; According to the cause of disease and different clinical manifestations, numbness disease is divided into by ancient medicine document: migratory arthralgia, arthralgia aggravated by cold, damp arthralgia, general arthralgia, severe and migratory arthralgia, gout, arthralgia due to stagnation of blood, BI-syndrome related to skin, rheumatoid arthritis etc., cause limbs pain, numbness, arthralgia, stiff, distortion, affect limb function movable, even lose life and work ability, and have influence on the viscera functions such as the heart, lung, liver,spleen,kidney, and be a kind of multiple obstinate difficult disease, serious harm health.
Rheumatoid arthritis is a kind of with the non-infectious inflammation of joint and periarticular tissue, belongs to the systemic disease of immunologic function disorder, can cause the viscera diseases such as pericarditis, myocarditis, pneumonia, pleuritis, be more common between twenty and fifty women.Its joint symptoms feature is: from the beginning of the Minor articulus such as invade hands, foot, wrist, refer to more, articular cavity synovial membrane is inflamed, sepage, cell proliferation, cartilage and bone destruction, thereafter the large joint involvement such as ankle, knee joint, hip, elbow, shoulder, spinal column, occurs that morning stiff, red, swollen, hot, bitterly, joint deformity, paralysis, fatality rate is high, belongs to severe and migratory arthralgia disease insensitive impediment category.
The clinical manifestation mainly osteoarthrosis of gout, rheumatism, rheumatoid arthritis, its etiology and pathogenesis belongs to traditional Chinese medical science severe and migratory arthralgia arthromyodynia category together, can treating different diseases with the same therapeutic principle.
Prior art treatment gout, rheumatism, rheumatoid arthritis, mainly adopt pain relieving, antiinflammatory, adrenocortical hormones treatment, easily cause drug dependence, Drug resistance, and side effect be large, easily damages gastrointestinal, hepatic and renal function.Long-term taking Chinese medicine decoction or various Chinese patent medicine preparation, have certain curative effect, but decoct, preserve, taken certain difficulty, and it is slow to take effect, and a lot of patient can not adhere to, the medicated wine of some externals does not all have good curative effect.At present, traditional treatment gout, rheumatism rheumatoid arthritis medicine exists and orally causes serious toxic and side effects, and decoct, preserve, take process difficult, take effect slow, patient can not adhere to for a long time, the problem of therapeutic effect difference.
Summary of the invention
The object of the embodiment of the present invention is to provide one to treat gout, rheumatism rheumatoid arthritis and swells and ache topical agent and preparation method, be intended to solve traditional treatment gout, rheumatism rheumatoid arthritis medicine exist and orally cause serious toxic and side effects, decoct, preserve, take process difficult, take effect slow, patient can not adhere to for a long time, the problem of therapeutic effect difference.
The embodiment of the present invention is achieved in that one is treated gout, rheumatism rheumatoid arthritis and to be swollen and ache topical agent, pharmaceutical formulation and the quality proportioning thereof of this topical agent be (g measures unit: g):
Radix Aconiti 20-120g, Radix Aconiti Kusnezoffii 20-120g, Semen Strychni 20-120g, Radix Tripterygii Wilfordii 20-120g, Rhizoma Et Radix Notopterygii 20-100g, Radix Angelicae Pubescentis 20-100g, Herba Ephedrae 20-90g, Ramulus Cinnamomi 20-90g, Herba Asari 20-90g, Radix Clematidis 20-120g, Rhizoma Atractylodis 20-120g, Cortex Phellodendri 20-100g, Pericarpium Zanthoxyli 20-90g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 20-100g, Radix Angelicae Sinensis 20-90g, Rhizoma Chuanxiong 20-120g, Rhizoma Arisaematis 20-90g, Fructus Broussonetiae 20-120g, Scorpio 20-90g, Scolopendra 20-90g, Eupolyphaga Seu Steleophaga 20-120g, Olibanum 30-100g, Myrrha 30-100g, Radix Cyathulae 30-120g, Borneolum Syntheticum 20-100g.
One is treated gout, rheumatism rheumatoid arthritis and to be swollen and ache topical agent, the preferred mass proportioning of this topical agent be (g measures unit: g):
Radix Aconiti 30-60g, Radix Aconiti Kusnezoffii 30-60g, Semen Strychni 30-60g, Radix Tripterygii Wilfordii 30-60g, Rhizoma Et Radix Notopterygii 30-60g, Radix Angelicae Pubescentis 30-60g, Herba Ephedrae 20-50g, Ramulus Cinnamomi 30-50g, Herba Asari 30-50g, Radix Clematidis 30-60g, Rhizoma Atractylodis 30-60g, Cortex Phellodendri 20-60g, Pericarpium Zanthoxyli 20-50g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30-60g, Radix Angelicae Sinensis 30-50g, Rhizoma Chuanxiong 30-60g, Rhizoma Arisaematis 20-50g, Fructus Broussonetiae 30-60g, Scorpio 20-50g, Scolopendra 20-50g, Eupolyphaga Seu Steleophaga 20-50g, Olibanum 30-50g, Myrrha 30-50g, Radix Cyathulae 30-60g, Borneolum Syntheticum 20-60g.
One is treated gout, rheumatism rheumatoid arthritis and to be swollen and ache topical agent, the best in quality proportioning of this topical agent be (g measures unit: g):
Radix Aconiti 90g, Radix Aconiti Kusnezoffii 90g, Semen Strychni 90g, Radix Tripterygii Wilfordii 90g, Rhizoma Et Radix Notopterygii 80g, Radix Angelicae Pubescentis 80g, Herba Ephedrae 60g, Ramulus Cinnamomi 80g, Herba Asari 60g, Radix Clematidis 90g, Rhizoma Atractylodis 80g, Cortex Phellodendri 80g, Pericarpium Zanthoxyli 60g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 80g, Radix Angelicae Sinensis 80g, Rhizoma Chuanxiong 90g, Rhizoma Arisaematis 60g, Fructus Broussonetiae 80g, Scorpio 60g, Scolopendra 40g, Eupolyphaga Seu Steleophaga 80g, Olibanum 80g, Myrrha 80g, Radix Cyathulae 90g, Borneolum Syntheticum 80g.
Further, the described treatment gout, rheumatism rheumatoid arthritis different medicine of the concrete formula of topical agent that swells and ache possesses different effects and synergism, and formula adopts: Radix Aconiti, Radix Aconiti Kusnezoffii, Semen Strychni, Radix Tripterygii Wilfordii, expelling wind and removing dampness cold expelling, promoting blood circulation and detumescence, removing obstruction in the collateral to relieve pain power is extremely strong, is monarch drug;
Adopt Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Herba Ephedrae, Ramulus Cinnamomi, Herba Asari, Radix Clematidis, Rhizoma Atractylodis, Pericarpium Zanthoxyli, pungent warm-dryness syndrome wets, dispersing wind-cold, tonneau general joint, kind cold-dispelling damp, and the stupid fiber crops in limb muscle joint are swollen and ache, and are ministerial drug;
Adopt Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Angelicae Sinensis, Rhizoma Chuanxiong, blood circulation promoting and blood stasis dispelling, circulation of qi promoting of stimulating the menstrual flow, detumescence and promoting granulation promoting blood circulation and stopping pain; Scorpio, Scolopendra, Eupolyphaga Seu Steleophaga, Borneolum Syntheticum, wear muscle deep, dredge the meridian passage, and separate spasm, dispersing pathogen accumulation, searches wind by heresy, reducing swelling and alleviating pain; The Rhizoma Arisaematis expectorant that dispels the wind is detained meridians, mass dissipating and swelling eliminating; Cortex Phellodendri, bitter dry clear damp-heat in lower-JIAO, reducing the asthenic fever hectic fever due to YIN-deficiency, is Punching line with Rhizoma Atractylodis, Radix Achyranthis Bidentatae compatibility, controls damp invasion of lower energizer, foot swelling and pain in knee; Fructus Broussonetiae and Radix Clematidis compatibility are ancient prescription shot, and the power of hard masses softening and resolving is very strong, coordinates Rhizoma Arisaematis, Scorpio, Scolopendra, Eupolyphaga Seu Steleophaga, penetrates meridians muscles and bones, the tophus of the turbid formation of dissipation blood stasis expectorant, rheumatism joint, arthroedema, and above is adjuvant drug altogether;
Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii are that tying-in makes medicine above the waist; Radix Angelicae Pubescentis, Radix Cyathulae are that lower part of the body tying-in makes medicine; The sensible whole body twelve channels and collaterals of Radix Clematidis, walks and does not keep, and is gout key medicine, also for whole body tying-in makes medicine;
Full side's compatibility is rigorous, and the efficacy of a drug is intrepid, is the desirable reducing swelling and alleviating pain topical agent for the treatment of gout, rheumatism, rheumatoid arthritis.
Treat gout, rheumatism rheumatoid arthritis to swell and ache the preparation method of topical agent, this preparation method adopts different process to be prepared into the dosage form such as tincture, spray.
Treat gout, rheumatism rheumatoid arthritis to swell and ache the preparation method of external-use tincture, this preparation method technological process comprise weigh by best in quality proportioning, load container, take ethanol, immersion, filtration, medicinal residues process, precipitation, bottled;
Described weighing by best in quality proportioning refers to and is purified respectively by best in quality proportioning by pharmaceutical formulation, and claim sufficient g to measure, Borneolum Syntheticum separately fills, and all the other pharmaceutical dryings are pulverized as coarser powder;
Described loading container refers to and is loaded in capped container by the medicine pulverized as coarser powder, adds Borneolum Syntheticum 1.45kg altogether simultaneously;
Described take ethanol to refer to the medicinal alcohol of employing 70% is 8 times amount of drug quality, i.e. 11.6kg;
Described immersion refers to 11.6kg medicinal alcohol to pour in medicament reservoir and stirs evenly, and soak 15 days under the room temperature of 25 DEG C, every day stirs twice;
Described filtration refer to the immersion medicinal liquid of 15 days all leached load precipitate in sealed container for subsequent use;
Described medicinal residues process refers to medicinal alcohol medicinal residues being added again triplication, and namely 4.35kg stirs evenly sealing, and every day stirs twice, soaks that to leach medicinal liquid precipitation after 10 days for subsequent use;
Described precipitation refers to and twice is leached medicinal liquid to close even precipitation 36h for subsequent use;
Clarification medicinal liquid is divided in tailormadepiston bottle by described bottled referring to, every bottle of 100ml, sealing, is namely prepared into treatment gout, rheumatism rheumatoid arthritis and swells and ache external-use tincture.
Treat gout, rheumatism rheumatoid arthritis to swell and ache the using method of external-use tincture, this using method is: put affected part on the skin 10-15 time outside gout, rheumatism, rheumatoid arthritis patients cotton swab every day libation at an ancient wedding ceremony medicine, attention can not be put on the skin in entrance, eye.
Treat gout, rheumatism rheumatoid arthritis to swell and ache the preparation method of external spraying agent, this preparation method technological process comprises weighs by upper limit quality proportioning, medical preconditioning, loading container, takes ethanol, immersion, filtration, medicinal residues process, precipitates, is prepared as spray;
Described weighing by upper limit quality proportioning refers to that (g measures unit: g) weigh: Radix Aconiti 120g by upper limit quality proportioning by pharmaceutical formulation, Radix Aconiti Kusnezoffii 120g, Semen Strychni 120g, Radix Tripterygii Wilfordii 120g, Rhizoma Et Radix Notopterygii 100g, Radix Angelicae Pubescentis 100g, Herba Ephedrae 90g, Ramulus Cinnamomi 90g, Herba Asari 90g, Radix Clematidis 120g, Rhizoma Atractylodis 120g, Cortex Phellodendri 100g, Pericarpium Zanthoxyli 90g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 100g, Radix Angelicae Sinensis 90g, Rhizoma Chuanxiong 120g, Rhizoma Arisaematis 90g, Fructus Broussonetiae 120g, Scorpio 90g, Scolopendra 90g, Eupolyphaga Seu Steleophaga 120g, Olibanum 100g, Myrrha 100g, Radix Cyathulae 120g, Borneolum Syntheticum 100g,
Described medical preconditioning refers to above drug purification dry, and claim sufficient g to measure, Borneolum Syntheticum separately equips use, and it is coarser powder that other medicines close even pulverizing;
Described loading container refers to and is loaded in capped container by coarser powder medicine, adds Borneolum Syntheticum simultaneously, altogether heavy 2710g;
Described take ethanol to refer to the ethanol of employing 75% is 6 times amount of drug quality, i.e. 16.26kg;
Described immersion refers to 16.26kg medicinal alcohol to pour in medicament reservoir and stirs evenly, and soak 15 days under 25 DEG C of room temperature, every day stirs twice;
Described filtration refer to the immersion medicinal liquid of 15 days all leached load precipitate in sealed container for subsequent use;
Described medicinal residues process refers to medicinal alcohol medicinal residues being added again triplication, and namely 8.13kg stirs evenly sealing, and every day stirs twice, soaks that to leach medicinal liquid precipitation after 10 days for subsequent use;
Described precipitation refers to and twice is leached medicinal liquid to close even precipitation 36h for subsequent use;
The described spray that is prepared as refers to clarification medicinal liquid employing spray technology of preparing, is prepared as spray, is packed as every 100ml mono-bottle.
Treat gout, rheumatism rheumatoid arthritis to swell and ache the using method of external spraying agent, this using method is: every day uses spray 5-10 time to affected part, attention can not entrance, in eye.
The present invention adopts primary authentic medicinal herbs to purify and pulverizes, long-time sealing immersion twice, fully moltenly bubble out active ingredient g in medicine, enhance external drug effect, acute and chronic gouty arthritis can be treated, swell and ache hard to bear, leach tophus, rheumatism, rheumatoid arthritis swell and ache unbearably, ankylosis, human body paralysis and podomere distortion, improve functional activity; Adopt tincture of the present invention or aerosol therapy rheumatism, rheumatoid arthritis, reducing swelling and alleviating pain effective percentage reaches 95%; The present invention is pure Chinese medicinal preparation, not containing any Western medicine hormone, without drug dependence; Topical agent therapeutic domain is wide, also has significant curative effect to scapulohumeral periarthritis, cervical spondylosis, and portably uses conveniently.The treatment gout, rheumatism rheumatoid arthritis topical agent raw material that swells and ache is easy to get, and with low cost, production technology is simple, and patient is easy to use, instant effect, can remove misery at short notice, and therapeutic effect is good.
Accompanying drawing explanation
Fig. 1 is that treatment gout, rheumatism rheumatoid arthritis that the embodiment of the present invention provides swells and ache the process chart of preparation method of external-use tincture;
Fig. 2 is that treatment gout, rheumatism rheumatoid arthritis that the embodiment of the present invention provides swells and ache the process chart of preparation method of external spraying agent.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Below in conjunction with drawings and the specific embodiments, application principle of the present invention is further described.
The embodiment of the present invention is achieved in that one is treated gout, rheumatism rheumatoid arthritis and to be swollen and ache topical agent, pharmaceutical formulation and the quality proportioning thereof of this topical agent be (g measures unit: g):
Radix Aconiti 20-120g, Radix Aconiti Kusnezoffii 20-120g, Semen Strychni 20-120g, Radix Tripterygii Wilfordii 20-120g, Rhizoma Et Radix Notopterygii 20-100g, Radix Angelicae Pubescentis 20-100g, Herba Ephedrae 20-90g, Ramulus Cinnamomi 20-90g, Herba Asari 20-90g, Radix Clematidis 20-120g, Rhizoma Atractylodis 20-120g, Cortex Phellodendri 20-100g, Pericarpium Zanthoxyli 20-90g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 20-100g, Radix Angelicae Sinensis 20-90g, Rhizoma Chuanxiong 20-120g, Rhizoma Arisaematis 20-90g, Fructus Broussonetiae 20-120g, Scorpio 20-90g, Scolopendra 20-90g, Eupolyphaga Seu Steleophaga 20-120g, Olibanum 30-100g, Myrrha 30-100g, Radix Cyathulae 30-120g, Borneolum Syntheticum 20-100g.
One is treated gout, rheumatism rheumatoid arthritis and to be swollen and ache topical agent, the preferred mass proportioning of this topical agent be (g measures unit: g):
Radix Aconiti 30-60g, Radix Aconiti Kusnezoffii 30-60g, Semen Strychni 30-60g, Radix Tripterygii Wilfordii 30-60g, Rhizoma Et Radix Notopterygii 30-60g, Radix Angelicae Pubescentis 30-60g, Herba Ephedrae 20-50g, Ramulus Cinnamomi 30-50g, Herba Asari 30-50g, Radix Clematidis 30-60g, Rhizoma Atractylodis 30-60g, Cortex Phellodendri 20-60g, Pericarpium Zanthoxyli 20-50g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30-60g, Radix Angelicae Sinensis 30-50g, Rhizoma Chuanxiong 30-60g, Rhizoma Arisaematis 20-50g, Fructus Broussonetiae 30-60g, Scorpio 20-50g, Scolopendra 20-50g, Eupolyphaga Seu Steleophaga 20-50g, Olibanum 30-50g, Myrrha 30-50g, Radix Cyathulae 30-60g, Borneolum Syntheticum 20-60g.
One is treated gout, rheumatism rheumatoid arthritis and to be swollen and ache topical agent, the best in quality proportioning of this topical agent be (g measures unit: g):
Radix Aconiti 90g, Radix Aconiti Kusnezoffii 90g, Semen Strychni 90g, Radix Tripterygii Wilfordii 90g, Rhizoma Et Radix Notopterygii 80g, Radix Angelicae Pubescentis 80g, Herba Ephedrae 60g, Ramulus Cinnamomi 80g, Herba Asari 60g, Radix Clematidis 90g, Rhizoma Atractylodis 80g, Cortex Phellodendri 80g, Pericarpium Zanthoxyli 60g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 80g, Radix Angelicae Sinensis 80g, Rhizoma Chuanxiong 90g, Rhizoma Arisaematis 60g, Fructus Broussonetiae 80g, Scorpio 60g, Scolopendra 40g, Eupolyphaga Seu Steleophaga 80g, Olibanum 80g, Myrrha 80g, Radix Cyathulae 90g, Borneolum Syntheticum 80g.
Further, the described treatment gout, rheumatism rheumatoid arthritis different medicine of the concrete formula of topical agent that swells and ache possesses different effects and synergism, and formula adopts: Radix Aconiti, Radix Aconiti Kusnezoffii, Semen Strychni, Radix Tripterygii Wilfordii, expelling wind and removing dampness cold expelling, promoting blood circulation and detumescence, removing obstruction in the collateral to relieve pain power is extremely strong, is monarch drug.
Adopt Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Herba Ephedrae, Ramulus Cinnamomi, Herba Asari, Radix Clematidis, Rhizoma Atractylodis, Pericarpium Zanthoxyli, pungent warm-dryness syndrome wets, dispersing wind-cold, tonneau general joint, kind cold-dispelling damp, and the stupid fiber crops in limb muscle joint are swollen and ache, and are ministerial drug;
Adopt Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Angelicae Sinensis, Rhizoma Chuanxiong, blood circulation promoting and blood stasis dispelling, circulation of qi promoting of stimulating the menstrual flow, detumescence and promoting granulation promoting blood circulation and stopping pain; Scorpio, Scolopendra, Eupolyphaga Seu Steleophaga, Borneolum Syntheticum, wear muscle deep, dredge the meridian passage, and separate spasm, dispersing pathogen accumulation, searches wind by heresy, reducing swelling and alleviating pain; The Rhizoma Arisaematis expectorant that dispels the wind is detained meridians, mass dissipating and swelling eliminating; Cortex Phellodendri, bitter dry clear damp-heat in lower-JIAO, reducing the asthenic fever hectic fever due to YIN-deficiency, is Punching line with Rhizoma Atractylodis, Radix Achyranthis Bidentatae compatibility, controls damp invasion of lower energizer, foot swelling and pain in knee; Fructus Broussonetiae and Radix Clematidis compatibility are ancient prescription shot, and the power of hard masses softening and resolving is very strong, coordinates Rhizoma Arisaematis, Scorpio, Scolopendra, Eupolyphaga Seu Steleophaga, penetrates meridians muscles and bones, and the tophus of the turbid formation of dissipation blood stasis expectorant, rheumatism joint, arthroedema, above is adjuvant drug altogether.
Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii are that tying-in makes medicine above the waist; Radix Angelicae Pubescentis, Radix Cyathulae are that lower part of the body tying-in makes medicine; The sensible whole body twelve channels and collaterals of Radix Clematidis, walks and does not keep, and is gout key medicine, also for whole body tying-in makes medicine;
Full side's compatibility is rigorous, and the efficacy of a drug is intrepid, is the desirable reducing swelling and alleviating pain topical agent for the treatment of gout, rheumatism, rheumatoid arthritis.
Treat gout, rheumatism rheumatoid arthritis to swell and ache the preparation method of topical agent, this preparation method adopts different process to be prepared into the dosage form such as tincture, spray.
As shown in Figure 1, treat gout, rheumatism rheumatoid arthritis to swell and ache the preparation method of external-use tincture, this preparation method technological process comprise by best in quality proportioning weigh S101, load container S102, take ethanol S103, soak S104, filter S105, medicinal residues treatment S 106, precipitation S107, bottled S108;
Described refer to purified respectively by best in quality proportioning by pharmaceutical formulation by the best in quality proportioning S101 that weighs, claim sufficient g to measure, Borneolum Syntheticum separately fills, and all the other pharmaceutical dryings are pulverized as coarser powder;
Described loading container S102 refers to and is loaded in capped container by the medicine pulverized as coarser powder, adds Borneolum Syntheticum 1.45kg altogether simultaneously;
Described take ethanol S103 to refer to the medicinal alcohol of employing 70% is 8 times amount of drug quality, i.e. 11.6kg;
Described immersion S104 refers to 11.6kg medicinal alcohol to pour in medicament reservoir and stirs evenly, and soak 15 days under the room temperature of 25 DEG C, every day stirs twice;
Described filtration S105 refer to the immersion medicinal liquid of 15 days all leached load precipitate in sealed container for subsequent use;
Described medicinal residues treatment S 106 refers to medicinal alcohol medicinal residues being added again triplication, and namely 4.35kg stirs evenly sealing, and every day stirs twice, soaks that to leach medicinal liquid precipitation after 10 days for subsequent use;
Described precipitation S107 refers to and twice is leached medicinal liquid to close even precipitation 36h for subsequent use;
Described bottled S108 refers to and is divided in tailormadepiston bottle by clarification medicinal liquid, every bottle of 100ml, sealing, is namely prepared into treatment gout, rheumatism rheumatoid arthritis and swells and ache external-use tincture.
Treat gout, rheumatism rheumatoid arthritis to swell and ache the using method of external-use tincture, this using method is: put affected part on the skin 10-15 time outside gout, rheumatism, rheumatoid arthritis patients cotton swab every day libation at an ancient wedding ceremony medicine, attention can not be put on the skin in entrance, eye.
As shown in Figure 2, treat gout, rheumatism rheumatoid arthritis to swell and ache the preparation method of external spraying agent, this preparation method technological process comprise by upper limit quality proportioning weigh S201, medical preconditioning S202, load container S203, take ethanol S204, soak S205, filter S206, medicinal residues treatment S 207, precipitate S208, be prepared as spray S209;
Described refer to that (g measures unit: g) weigh: Radix Aconiti 120g by upper limit quality proportioning by pharmaceutical formulation by the upper limit quality proportioning S201 that weighs, Radix Aconiti Kusnezoffii 120g, Semen Strychni 120g, Radix Tripterygii Wilfordii 120g, Rhizoma Et Radix Notopterygii 100g, Radix Angelicae Pubescentis 100g, Herba Ephedrae 90g, Ramulus Cinnamomi 90g, Herba Asari 90g, Radix Clematidis 120g, Rhizoma Atractylodis 120g, Cortex Phellodendri 100g, Pericarpium Zanthoxyli 90g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 100g, Radix Angelicae Sinensis 90g, Rhizoma Chuanxiong 120g, Rhizoma Arisaematis 90g, Fructus Broussonetiae 120g, Scorpio 90g, Scolopendra 90g, Eupolyphaga Seu Steleophaga 120g, Olibanum 100g, Myrrha 100g, Radix Cyathulae 120g, Borneolum Syntheticum 100g,
Described medical preconditioning S202 refers to above drug purification dry, and claim sufficient g to measure, Borneolum Syntheticum separately equips use, and it is coarser powder that other medicines close even pulverizing;
Described loading container S203 refers to and is loaded in capped container by coarser powder medicine, adds Borneolum Syntheticum simultaneously, altogether heavy 2710g;
Described take ethanol S204 to refer to the ethanol of employing 75% is 6 times amount of drug quality, i.e. 16.26kg;
Described immersion S205 refers to 16.26kg medicinal alcohol to pour in medicament reservoir and stirs evenly, and soak 15 days under 25 DEG C of room temperature, every day stirs twice;
Described filtration S206 refer to the immersion medicinal liquid of 15 days all leached load precipitate in sealed container for subsequent use;
Described medicinal residues treatment S 207 refers to medicinal alcohol medicinal residues being added again triplication, and namely 8.13kg stirs evenly sealing, and every day stirs twice, soaks that to leach medicinal liquid precipitation after 10 days for subsequent use;
Described precipitation S208 refers to and twice is leached medicinal liquid to close even precipitation 36h for subsequent use;
The described spray S209 that is prepared as refers to clarification medicinal liquid employing spray technology of preparing, is prepared as spray, is packed as every 100ml mono-bottle.
Treat gout, rheumatism rheumatoid arthritis to swell and ache the using method of external spraying agent, this using method is: every day uses spray 5-10 time to affected part, attention can not entrance, in eye.
As shown in Figure 1, 2, treat gout, rheumatism rheumatoid arthritis to swell and ache the preparation method of external-use tincture, this preparation method technological process comprise by best in quality proportioning weigh S101, load container S102, take ethanol S103, soak S104, filter S105, medicinal residues treatment S 106, precipitation S107, bottled S108; Described refer to purified respectively by best in quality proportioning by pharmaceutical formulation by the best in quality proportioning S101 that weighs, claim sufficient g to measure, Borneolum Syntheticum separately fills, and all the other pharmaceutical dryings are pulverized as coarser powder; Described loading container S102 refers to and is loaded in capped container by the medicine pulverized as coarser powder, adds Borneolum Syntheticum 1.45kg altogether simultaneously; Described take ethanol S103 to refer to the medicinal alcohol of employing 70% is 8 times amount of drug quality, i.e. 11.6kg; Described immersion S104 refers to 11.6kg medicinal alcohol to pour in medicament reservoir and stirs evenly, and soak 15 days under the room temperature of 25 DEG C, every day stirs twice; Described filtration S105 refer to the immersion medicinal liquid of 15 days all leached load precipitate in sealed container for subsequent use; Described medicinal residues treatment S 106 refers to medicinal alcohol medicinal residues being added again triplication, and namely 4.35kg stirs evenly sealing, and every day stirs twice, soaks that to leach medicinal liquid precipitation after 10 days for subsequent use; Described precipitation S107 refers to and twice is leached medicinal liquid to close even precipitation 36h for subsequent use; Described bottled S108 refers to and is divided in tailormadepiston bottle by clarification medicinal liquid, every bottle of 100ml, sealing, is namely prepared into treatment gout, rheumatism rheumatoid arthritis and swells and ache external-use tincture; The swell and ache using method of external-use tincture of this treatment gout, rheumatism rheumatoid arthritis is: put affected part on the skin 10-15 time outside gout, rheumatism, rheumatoid arthritis patients cotton swab every day libation at an ancient wedding ceremony medicine, can not put on the skin in entrance, eye.
Clinical practice of the present invention more than 10 year, through improving adjustment formula, dosage, curative effect is more shown in significantly.From year March in October, 2010 to 2014, come tracing study more 3 years and have collected patient with gout 194 example, wherein women 6 example (history of being addicted to drink), male 188 example.Acute onset person 83 example first, 111 examples are the chronic patient that repeatedly falls ill, concurrent renal insufficiency person 68 example.Collect rheumatism joint to swell and ache patient 167 example, wherein women 93 example, male 74 example, mainly cold the and underwater work person of peasant, underground labour or high mountain.Mainly swell and ache with foot, knee joint, ankle, elbow, wrist, articulations digitorum manus; Chronic rheumatoid patient concurrent rheumatic heart disease patient 32 example, patients with cor pulmonale 18 example (age 50-70 year, all have addicted to cigarette history).Collect patient with rheumatoid arthritis 146 example, main occupation is peasant, and part is for being industry workman in field, down-hole.Wherein women 124 people, male 22 people, mostly be 25-45 year between twenty and fifty.Mainly brothers' Minor articulus swells and ache, morning is stiff, red, swollen, hot, bitterly, tenderness, part occurs that ankle, knee joint, hip, shoulder, thoracolumbar vertebrae, joint of vertebral column are scorching, and wherein 35 routine patients have visceral lesion, 22 routine patient's extremities joints deformities.Above case all adopts outside tincture medicated wine of the present invention and puts affected part on the skin, every day 10-15 time, and about 70% patient 1-3 days swells and ache and obviously improves, and the patient of 10-15 day 95% swells and ache disappearances, the improvement of limb activity function; Patient's drug withdrawal because of skin allergy of about 5%.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (4)
1. treat gout, rheumatism rheumatoid arthritis to swell and ache a topical agent, it is characterized in that, pharmaceutical formulation and the quality proportioning thereof of this topical agent are:
Radix Aconiti 20-120g, Radix Aconiti Kusnezoffii 20-120g, Semen Strychni 20-120g, Radix Tripterygii Wilfordii 20-120g, Rhizoma Et Radix Notopterygii 20-100g, Radix Angelicae Pubescentis 20-100g, Herba Ephedrae 20-90g, Ramulus Cinnamomi 20-90g, Herba Asari 20-90g, Radix Clematidis 20-120g, Rhizoma Atractylodis 20-120g, Cortex Phellodendri 20-100g, Pericarpium Zanthoxyli 20-90g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 20-100g, Radix Angelicae Sinensis 20-90g, Rhizoma Chuanxiong 20-120g, Rhizoma Arisaematis 20-90g, Fructus Broussonetiae 20-120g, Scorpio 20-90g, Scolopendra 20-90g, Eupolyphaga Seu Steleophaga 20-120g, Olibanum 30-100g, Myrrha 30-100g, Radix Cyathulae 30-120g, Borneolum Syntheticum 20-100g.
2. treatment gout, rheumatism rheumatoid arthritis as claimed in claim 1 swells and ache topical agent, and it is characterized in that, the quality proportioning of this topical agent can also adopt:
Radix Aconiti 30-60g, Radix Aconiti Kusnezoffii 30-60g, Semen Strychni 30-60g, Radix Tripterygii Wilfordii 30-60g, Rhizoma Et Radix Notopterygii 30-60g, Radix Angelicae Pubescentis 30-60g, Herba Ephedrae 20-50g, Ramulus Cinnamomi 30-50g, Herba Asari 30-50g, Radix Clematidis 30-60g, Rhizoma Atractylodis 30-60g, Cortex Phellodendri 20-60g, Pericarpium Zanthoxyli 20-50g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30-60g, Radix Angelicae Sinensis 30-50g, Rhizoma Chuanxiong 30-60g, Rhizoma Arisaematis 20-50g, Fructus Broussonetiae 30-60g, Scorpio 20-50g, Scolopendra 20-50g, Eupolyphaga Seu Steleophaga 20-50g, Olibanum 30-50g, Myrrha 30-50g, Radix Cyathulae 30-60g, Borneolum Syntheticum 20-60g.
3. treatment gout, rheumatism rheumatoid arthritis as claimed in claim 1 swells and ache topical agent, and it is characterized in that, the quality proportioning of this topical agent can also adopt:
Radix Aconiti 90g, Radix Aconiti Kusnezoffii 90g, Semen Strychni 90g, Radix Tripterygii Wilfordii 90g, Rhizoma Et Radix Notopterygii 80g, Radix Angelicae Pubescentis 80g, Herba Ephedrae 60g, Ramulus Cinnamomi 80g, Herba Asari 60g, Radix Clematidis 90g, Rhizoma Atractylodis 80g, Cortex Phellodendri 80g, Pericarpium Zanthoxyli 60g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 80g, Radix Angelicae Sinensis 80g, Rhizoma Chuanxiong 90g, Rhizoma Arisaematis 60g, Fructus Broussonetiae 80g, Scorpio 60g, Scolopendra 40g, Eupolyphaga Seu Steleophaga 80g, Olibanum 80g, Myrrha 80g, Radix Cyathulae 90g, Borneolum Syntheticum 80g.
4. treat gout, rheumatism rheumatoid arthritis to swell and ache the preparation method of topical agent, it is characterized in that, this preparation method adopts different process to be prepared into tincture, spray formulations;
Treatment gout, rheumatism rheumatoid arthritis swell and ache the technological process of preparation method of external-use tincture comprise weigh by best in quality proportioning, load container, take ethanol, immersion, filtration, medicinal residues process, precipitation, bottled;
Described weighing by best in quality proportioning refers to and is purified respectively by best in quality proportioning by pharmaceutical formulation, and claim sufficient g to measure, Borneolum Syntheticum separately fills, and all the other pharmaceutical dryings are pulverized as coarser powder;
Described loading container refers to and is loaded in capped container by the medicine pulverized as coarser powder, adds Borneolum Syntheticum 1.45kg altogether simultaneously;
Described take ethanol to refer to the medicinal alcohol of employing 70% is 8 times amount of drug quality, i.e. 11.6kg;
Described immersion refers to 11.6kg medicinal alcohol to pour in medicament reservoir and stirs evenly, and soak 15 days under the room temperature of 25 DEG C, every day stirs twice;
Described filtration refer to the immersion medicinal liquid of 15 days all leached load precipitate in sealed container for subsequent use;
Described medicinal residues process refers to medicinal alcohol medicinal residues being added again triplication, and namely 4.35kg stirs evenly sealing, and every day stirs twice, soaks that to leach medicinal liquid precipitation after 10 days for subsequent use;
Described precipitation refers to and twice is leached medicinal liquid to close even precipitation 36h for subsequent use;
Clarification medicinal liquid is divided in tailormadepiston bottle by described bottled referring to, every bottle of 100ml, sealing, is namely prepared into treatment gout, rheumatism rheumatoid arthritis and swells and ache external-use tincture;
The swell and ache technological process of preparation method of external spraying agent for the treatment of gout, rheumatism rheumatoid arthritis comprises and weighs by upper limit quality proportioning, medical preconditioning, loading container, takes ethanol, immersion, filtration, medicinal residues process, precipitates, is prepared as spray;
Described weighing by upper limit quality proportioning refers to that (g measures unit: g) weigh: Radix Aconiti 120g by upper limit quality proportioning by pharmaceutical formulation, Radix Aconiti Kusnezoffii 120g, Semen Strychni 120g, Radix Tripterygii Wilfordii 120g, Rhizoma Et Radix Notopterygii 100g, Radix Angelicae Pubescentis 100g, Herba Ephedrae 90g, Ramulus Cinnamomi 90g, Herba Asari 90g, Radix Clematidis 120g, Rhizoma Atractylodis 120g, Cortex Phellodendri 100g, Pericarpium Zanthoxyli 90g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 100g, Radix Angelicae Sinensis 90g, Rhizoma Chuanxiong 120g, Rhizoma Arisaematis 90g, Fructus Broussonetiae 120g, Scorpio 90g, Scolopendra 90g, Eupolyphaga Seu Steleophaga 120g, Olibanum 100g, Myrrha 100g, Radix Cyathulae 120g, Borneolum Syntheticum 100g,
Described medical preconditioning refers to above drug purification dry, and claim sufficient g to measure, Borneolum Syntheticum separately equips use, and it is coarser powder that other medicines close even pulverizing;
Described loading container refers to and is loaded in capped container by coarser powder medicine, adds Borneolum Syntheticum simultaneously, altogether heavy 2710g;
Described take ethanol to refer to the ethanol of employing 75% is 6 times amount of drug quality, i.e. 16.26kg;
Described immersion refers to 16.26kg medicinal alcohol to pour in medicament reservoir and stirs evenly, and soak 15 days under 25 DEG C of room temperature, every day stirs twice;
Described filtration refer to the immersion medicinal liquid of 15 days all leached load precipitate in sealed container for subsequent use;
Described medicinal residues process refers to medicinal alcohol medicinal residues being added again triplication, and namely 8.13kg stirs evenly sealing, and every day stirs twice, soaks that to leach medicinal liquid precipitation after 10 days for subsequent use;
Described precipitation refers to and twice is leached medicinal liquid to close even precipitation 36h for subsequent use;
The described spray that is prepared as refers to clarification medicinal liquid employing spray technology of preparing, is prepared as spray, is packed as every 100ml mono-bottle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410462242.2A CN104208324A (en) | 2014-09-11 | 2014-09-11 | External medicine for treating gall caused by gout, rheumatism and rheumatoid arthritis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410462242.2A CN104208324A (en) | 2014-09-11 | 2014-09-11 | External medicine for treating gall caused by gout, rheumatism and rheumatoid arthritis and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104208324A true CN104208324A (en) | 2014-12-17 |
Family
ID=52090497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410462242.2A Pending CN104208324A (en) | 2014-09-11 | 2014-09-11 | External medicine for treating gall caused by gout, rheumatism and rheumatoid arthritis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104208324A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997980A (en) * | 2015-07-21 | 2015-10-28 | 朱留臣 | Traditional Chinese medicine unguent for treating scapulohumeral periarthritis, cervical spondylosis and knee-joint hyperplasia |
| CN105213521A (en) * | 2015-11-18 | 2016-01-06 | 沙孝银 | External therapy of Chinese herb gout plaster |
| CN106421045A (en) * | 2016-10-26 | 2017-02-22 | 黔西南州神力中草药应用开发研究所 | Medicine for treating arthritis, rheumatism and metabolic arthritis and preparing method thereof |
| CN108815415A (en) * | 2018-07-18 | 2018-11-16 | 李朝阳 | A kind of external rheumatism ostalgia medicine and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899587A (en) * | 2006-07-12 | 2007-01-24 | 贵州山君生物工程有限公司 | Plaster for treating scapulohumeral periarthritis, arthritis, etc. and its preparing method |
| WO2012146194A1 (en) * | 2011-04-29 | 2012-11-01 | Industrial Technology Research Institute | Extracts of cynanchum sp. and active ingredients contained therein in use of arthritis treatment |
-
2014
- 2014-09-11 CN CN201410462242.2A patent/CN104208324A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899587A (en) * | 2006-07-12 | 2007-01-24 | 贵州山君生物工程有限公司 | Plaster for treating scapulohumeral periarthritis, arthritis, etc. and its preparing method |
| WO2012146194A1 (en) * | 2011-04-29 | 2012-11-01 | Industrial Technology Research Institute | Extracts of cynanchum sp. and active ingredients contained therein in use of arthritis treatment |
Non-Patent Citations (3)
| Title |
|---|
| 凌沛学: "《中药学概论》", 31 August 2007, 中国轻工业出版社 * |
| 蒋国民: "《气雾剂理论与技术》", 31 January 2011, 化学工业出版社 * |
| 陈友亮等: "辨证治疗类风湿性关节炎55例临床观察", 《内蒙古中医药》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997980A (en) * | 2015-07-21 | 2015-10-28 | 朱留臣 | Traditional Chinese medicine unguent for treating scapulohumeral periarthritis, cervical spondylosis and knee-joint hyperplasia |
| CN105213521A (en) * | 2015-11-18 | 2016-01-06 | 沙孝银 | External therapy of Chinese herb gout plaster |
| CN106421045A (en) * | 2016-10-26 | 2017-02-22 | 黔西南州神力中草药应用开发研究所 | Medicine for treating arthritis, rheumatism and metabolic arthritis and preparing method thereof |
| CN108815415A (en) * | 2018-07-18 | 2018-11-16 | 李朝阳 | A kind of external rheumatism ostalgia medicine and preparation method thereof |
| CN108815415B (en) * | 2018-07-18 | 2021-03-12 | 李朝阳 | Externally-applied medicine for treating rheumatic ostealgia and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102614389A (en) | Chinese medicinal patch | |
| CN103263659B (en) | Traditional Chinese medicine composition for treating rheumatism bone diseases | |
| CN104208324A (en) | External medicine for treating gall caused by gout, rheumatism and rheumatoid arthritis and preparation method thereof | |
| CN104689173B (en) | A kind of compound Chinese medicinal preparation for treating gout | |
| CN103071016A (en) | Traditional Chinese ointment for external use for curing osteoarthrosis such as cervical spondylosis and soft tissue injury | |
| CN103251695B (en) | Zhuifeng huaci wine for treating arthromyodynia and preparation method thereof | |
| CN104000933A (en) | Traditional Chinese medicine oral liquid for treating osteoproliferation | |
| CN103520682A (en) | Traditional Chinese medicine composition for treating rheumatism bone disease | |
| CN101829291B (en) | Traditional Chinese medicine preparation for treating rheumatism and preparation method thereof | |
| CN104623376B (en) | Be used for the treatment of prosopalgic medicine | |
| CN108295128B (en) | Traditional Chinese medicine compound preparation for treating rheumatoid arthritis and preparation method thereof | |
| CN105250374A (en) | Traditional Chinese medicine composition for treating cervical spondylosis | |
| CN103316296B (en) | Traditional Chinese medicine composition for treating hyperostosis | |
| CN104435250A (en) | Drug for treating varicocele | |
| CN103656506A (en) | Application powder for removing toxicity and dredging collaterals | |
| CN103028084A (en) | Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method | |
| CN103127458A (en) | Drug for treating osteoarticular myalgia | |
| CN103169876B (en) | Chinese medicament composition for treating arthralgia | |
| CN103751703A (en) | Chinese herbal medicinal liquor used for treating arthromyodynia and preparation method thereof | |
| CN104127856A (en) | Medicine used for treating knee osteoarthritis pain in anesthesia department and preparation method thereof | |
| CN103585294A (en) | Plaster for treating osteoproliferation and preparation method of plaster | |
| CN103285108B (en) | Chinese medicinal composition treating lumbago | |
| CN111419980B (en) | Pharmaceutical composition, preparation method, liquid medicament and application | |
| CN105641586A (en) | Fengtongning preparation and preparation method thereof | |
| CN105943700A (en) | Traditional Chinese medicine composition capable of tonifying kidney and relieving paralysis and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| AD01 | Patent right deemed abandoned |
Effective date of abandoning: 20190215 |
|
| AD01 | Patent right deemed abandoned |