CN106619877A - Composition for relieving bone joint pain, and preparation method of composition - Google Patents
Composition for relieving bone joint pain, and preparation method of composition Download PDFInfo
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- CN106619877A CN106619877A CN201710081414.5A CN201710081414A CN106619877A CN 106619877 A CN106619877 A CN 106619877A CN 201710081414 A CN201710081414 A CN 201710081414A CN 106619877 A CN106619877 A CN 106619877A
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Abstract
The invention relates to a composition for relieving bone joint pain, and a preparation method of the composition. The composition is prepared from the following components in parts by weight: 15-20 parts of an extract of fructus corni, 10-15 parts of an oyster extract, 10-15 parts of an astragalus root extract, 10-15 parts of a poria cocos extract, 3-5 parts of a fructus crataegi extract, 3-5 parts of glucosamine, 25-35 parts of water-soluble dietary fiber and 6-8 parts of a sweetening agent. The preparation method comprises the steps of evenly mixing the components, filling by using a full-automatic powder filling machine in a clean workshop, carrying out sampling inspection according to GB 7101 food safety national standard drink, packaging the qualified products and putting in storage. The composition is prepared by mixing the multiple extracts of traditional Chinese medicines and the glucosamine, has the effects of nourishing liver and kidney, dredging meridians and collaterals, reducing blood fat and blood pressure and guaranteeing smooth circulation of qi and blood, can relieve the bone joint pain, and stimulates chondrocyte synthesis so as to promote the repair for cartilage.
Description
Technical field
The present invention relates to food and health products manufacture field, and in particular to a kind of composition for improving osteoarthrosis pain and
Its preparation method.
Background technology
Bones and joints are connected by between adjacent bone by means of the capsule that connective tissue is constituted, and are to provide the required of physical activity, and Jing
Abrasion is avoided by cartilage protection bone.
As becoming occur in the soft tissues such as osteoarticular Long-Time Service and bone-loss, bone articular cartilage, interverbebral disc, ligament
Property, degeneration, formed and a kind of formed and joint deformity and cartilage with local cartilage degeneration, bone loss, marginal spurs
The chronic joint diseases that lower eburnation is characterized, are apt to occur in more than 50 years old crowd, and women is more than the male sex, in affecting in various degree
The quality of life of gerontal patient.
The case of nearly all chronic joint diseases has different degrees of pain, referred to as bone joint pain, and with disease
Journey is slowly in progress, and is mainly shown as painful swelling of joints, hydrops, stiff, hyperplasia, spur etc., and pain is bright when general joint comes into play
Show, slightly pain relief after activity, but when bearing a heavy burden with Bones and joints hyperactivity, pain can increase again, sometimes pain can be in and radiate
Property, such as hip arthralgia can be radiated to femoribus internus, and near knee joint, early stage visible joint is stiff, such as at knee joint long-time
When a certain position, feel unfavorable, the starting difficulty of activity, after engender joint instability, joint flexion-extension motion scope reduce and
Walking ability declines, and is become apparent from up/down steps, the ability decline such as squat down, run, jumping especially.
At present, Western medicine and pure Chinese medicine composition are adopted treatment Bones and joints on market more.Western medicine works comparatively fast, is with pain relieving more
It is main, can fast pain relief, but many compositions have side effect to human body, while serious drug resistance can be produced, to patient
Produce greatly injury；Also with good grounds bone joint pain Crack cause, supplements nutrition --- ammonia necessary to articular cartilage growth
Base glucose, promotes repair of cartilage, alleviates and treat bone joint pain with this；Pure Chinese medicine composition is mostly according to middle medical knowledge
Read, lost with caused by liver and kidney deficiency, muscles and bones support, channels and collaterals are inaccessible, qi and blood not freely as the main cause for causing arthralgia preparing, its is main
Effect is nourishing liver, invigorating kidney, alleviates arthralgia, but follow-up therapeutic effect can be poor.
The content of the invention
For having problems in prior art, the present invention is by the way of the combination of Chinese tradiational and Western medicine, it is considered to which bone joint pain is produced
The reason for, while fast pain relief, there is remarkable result to successive treatment, there is provided a kind of group for improving osteoarthrosis pain
Compound and preparation method thereof.
The technical solution adopted in the present invention is, a kind of composition for improving osteoarthrosis pain, the composition by with
The component composition of lower weight portion：15 ~ 20 parts of cornel extractive, 10 ~ 15 parts of oyster extract, 10 ~ 15 parts of Astragalus Root P.E, Fu
10 ~ 15 parts of Siberian cocklebur extract, 3 ~ 5 parts of haw thorn extract, 3 ~ 5 parts of Glucosamine, 25 ~ 35 parts of water-soluble dietary fiber, sweetener 6
~ 8 parts.
Preferably, the water-soluble dietary fiber is in FOS, oligoisomaltose, xylo-oligosaccharide, polydextrose
One or more of mixing.
Preferably, the sweetener is mannitol, one or more of steviol glycoside of mixing.
It is a kind of using the described preparation method for improving the composition of osteoarthrosis pain, the preparation method includes following
Step：
Step 1：Taking Fructus Corni, oyster, the Radix Astragali, Poria cocos, leaves of Hawthorn carries out extract preparation, and cornel extractive, oyster is obtained
Extract, Astragalus Root P.E, tuckahoe extracts, haw thorn extract；
Step 2：Take cornel extractive, oyster extract, Astragalus Root P.E, tuckahoe extracts, haw thorn extract, aminoglucose
Sugar, water-soluble dietary fiber and sweetener, are well mixed by component；
Step 3：Carried out with fully automatic powder bottle placer in dust proof workshop filling；
Step 4：According to GB 7101《National food safety standard beverage》Sampling inspection；
Step 5：Qualified products are packed, warehouse-in.
Preferably, in the step 1, the preparation method of the cornel extractive is comprised the following steps：
Step 1.1：With Fructus Corni as raw material, 24h is soaked with 95% ethanol, the volume of 95% ethanol is 6 times of raw material volume；
Step 1.2：Refluxing extraction 2 times, Extracting temperature is 60 DEG C, and extraction time is 2 h every time；Reflux extracting liquid merges after filtering
Filtrate, concentrates filtrate to the 1/5 of former filtrate volume, then will be centrifuged after gained concentrate aqueous precipitation；
Step 1.3：Precipitation reduced vacuum drying after step 1.2 is centrifuged to moisture is less than 5%, obtains extract A；
Step 1.4：Supernatant decompression after step 1.2 is centrifuged, after being concentrated into the 1/5 of former supernatant volume, inserts medium pole
Property or nonpolarity macroporous adsorptive resins chromatographic column, successively deionized water, 10% ~ 90% ethanol carry out gradient elution, collect eluent, will
Eluent liquid is evaporated to the 1/5 of former effluent volume, and reduced vacuum drying to moisture is less than 5%, obtains extract B；
Step 1.5：Uniform mixed extract A and extract B, cross 100 mesh sieves after crushing, cornel extractive is obtained.
Preferably, in the step 1, the preparation method of the oyster extract is comprised the following steps：
Step 2.1：With oyster meat as raw material, water extraction operation is carried out, water extraction temperature is 60 DEG C, and extraction time is 2 times；For the first time
Plus the deionized water of 10 times of oyster meat volume extracts 2h, the deionized water that 8 times of oyster meat volume is added for the second time extracts 1.5h；
Step 2.2：Merging filtrate after filtration, vacuum-concentrcted obtains concentrate to the 1/5 of former filtrate volume；
Step 2.3：Concentrate is less than into 5% with spray dryer drying to moisture, transient temperature is dried for 160 ~ 190 DEG C,
Outlet temperature is 85 ~ 100 DEG C；
Step 2.4：Gains are crushed, 100 mesh sieves are crossed, oyster extract is obtained.
Preferably, in the step 1, the preparation method of the Astragalus Root P.E is comprised the following steps：
Step 3.1：With Radix Astragali medicine materical crude slice as raw material, water extraction operation is carried out, water extraction temperature is 60 DEG C, and extraction time is 2 times；First
The deionized water of secondary plus 10 times of Radix Astragali medicine materical crude slice volume extracts 2h, and the deionized water that 8 times of Radix Astragali medicine materical crude slice volume is added for the second time is extracted
1.5h；
Step 3.2：After merging filtrate, vacuum-concentrcted obtains concentrate to the 1/5 of former filtrate volume；
Step 3.3：Concentrate vacuum decompression drying to moisture is less than into 5%；
Step 3.4：Gains are crushed, 100 mesh sieves are crossed, Astragalus Root P.E is obtained.
Preferably, in the step 1, the preparation method of the tuckahoe extracts is comprised the following steps：
Step 4.1：With Poria cocos as raw material, peeling is cleaned, and stripping and slicing is dried；
Step 4.2：Alcohol extracting method operation is carried out to the Poria cocos after process, alcohol extracting temperature is 60 DEG C, and extraction time is 2 times；Alcohol extracting is adopted
With the ethanol that concentration is 70%, each 2h, 8 times of 10 times of Poria cocos volume, second plus Poria cocos volume are added for the first time；
Step 4.3：After merging filtrate, vacuum-concentrcted obtains concentrate to the 1/5 of former filtrate volume；
Step 4.4：Concentrate vacuum decompression drying to moisture is less than into 5%；
Step 4.5：Gains are crushed, 100 mesh sieves are crossed, tuckahoe extracts are obtained.
Preferably, in the step 1, the preparation method of the haw thorn extract is comprised the following steps：
Step 5.1：With leaves of Hawthorn as raw material, meal is ground into；
Step 5.2：Alcohol extracting method operation is carried out to the meal after process, alcohol extracting temperature is 60 DEG C, and extraction time is 2 times；Alcohol extracting is adopted
With the ethanol that concentration is 50%, each 2h, 8 times of 10 times of coarse dispersion product, second plus coarse dispersion product are added for the first time；
Step 5.3：After merging filtrate, insert on macroporous absorbent resin, successively deionized water, the ethanol of 10% ~ 90% concentration are washed
It is de-, and collect eluent；
Step 5.4：Eluent is concentrated into into relative density for 1～1.2 at 60 DEG C；
Step 5.5：Concentrate reduced vacuum drying to moisture is less than into 5%；
Step 5.6：Gains are crushed, 100 mesh sieves are crossed, haw thorn extract is obtained.
The invention provides a kind of composition for improving osteoarthrosis pain and preparation method thereof, by mixing plurality of Chinese
Extract is constituted with Glucosamine, and nourishing liver, invigorating kidney, dredging the channel, blood fat-reducing blood pressure-decreasing, it is ensured that the effect that qi and blood passes unimpeded can alleviate bone
Arthralgia, while stimulating cartilage cell's synthesis, promotes the reparation of cartilage.
Present invention employs cornel extractive, oyster extract, Astragalus Root P.E, tuckahoe extracts, haw thorn extract,
The mixing of Glucosamine, water-soluble dietary fiber and sweetener, specifically acts on different：
Cornel extractive has diuresis and step-down rich in various active compositions such as oleanolic acid, ursolic acid, loganin, morronisides
Effect, can tonify the liver and kidney, and puckery essence is solid de-, and flat tonifying yin sun, no matter the deficiency of Yin or the deficiency of yang, can be used；
Oyster extract is often eaten and can be reduced with supplement calcium rich in taurine and the nutrient content such as mineral matter, especially calcium, zinc
The loss of bone calcium, taurine also has reducing blood lipid, hypotensive effect, and calming the liver, checking exuberance of yang tonifying yin is transquilization with heavy material, and softening hard masses dissipate
Knot；
Astragalus Root P.E is rich in Astragaloside IV, astragalus polyose, with strengthen immunity, strengthens energy, antifatigue, anti-mutation, guarantor
Liver, the effect for suppressing osteoclast, can strengthen body's immunity, cardiac stimulant step-down, hypoglycemic, diuresis, anti-aging, it is antifatigue,
Antitumor, antiviral, calm, analgesia etc.；
Tuckahoe extracts be rich in pachymaran, with strengthen physiologically active, stimulate human immune system functional rehabilitation, induce and
Stimulation effect interferon and leukoregulin, indirect antiviral, antineoplastic action, and have protecting liver, lowering enzymes, anti-aging, calm the nerves
Stomach invigorating, the effect of beautifying face and moistering lotion；
The active ingredient of haw thorn extract be flavones, can strong inhibition thyroid peroxidase, with anticancer, step-down, antibacterial,
Promoting blood circulation and removing blood stasis, reduction blood fat, the effect for suppressing platelet aggregation and spasmolysis；
Water-soluble dietary fiber can maintain intestinal microecology good, and anti-to treat constipation and colon cancer, reduce serum cholesterol delays Portugal
The absorption of grape sugar, adjusts blood sugar；Generally, water-soluble dietary fiber can be FOS, oligoisomaltose, oligomeric
The mixing of one or more in wood sugar, polydextrose；
Glucosamine is the important nutrient to form cartilage cell, is the natural tissues composition of healthy articular cartilage, Ke Yibang
Help reparation and safeguard cartilage, and the growth of cartilage cell can be stimulated；
Sweetener can give the food additives of soft drink sweet taste, be easy to adjust the composition entrance mouthfeel of the present invention；General feelings
Under condition, sweetener is mannitol, one or more of steviol glycoside of mixing.
The pain that product of the present invention is caused for Bones and joints due to the reason such as cartilage breakdown and degeneration, bone-loss, adopts
Combination of Chinese tradiational and Western medicine mode, there is remarkable result to successive treatment while alleviating bone joint pain, active ingredient is purified through multiple,
More preferably, and with powdery packaging, edible safety reliability is easy to carry, beneficial to absorption for effect.
Specific embodiment
The present invention is described in further detail with reference to embodiment, but protection scope of the present invention is not limited to
This.
Embodiment 1：
A kind of composition for improving osteoarthrosis pain, it is made up of the raw material of following weight portion：It is 20 parts of cornel extractive, male
10 parts of oyster extract, 10 parts of Astragalus Root P.E, 10 parts of tuckahoe extracts, 5 parts of haw thorn extract, 3 parts of Glucosamine, water solubility
35 parts of dietary fiber, 2 parts of mannitol, 5 parts of steviol glycoside.
Preparation method is comprised the following steps：
Step 1：Taking Fructus Corni, oyster, the Radix Astragali, Poria cocos, leaves of Hawthorn carries out extract preparation, using be obtained cornel extractive,
Oyster extract, Astragalus Root P.E, tuckahoe extracts, haw thorn extract；
Step 2：Take cornel extractive, oyster extract, Astragalus Root P.E, tuckahoe extracts, haw thorn extract, aminoglucose
Sugar, water-soluble dietary fiber and sweetener, are well mixed by component；
Step 3：Carried out with fully automatic powder bottle placer in dust proof workshop filling；
Step 4：According to GB 7101《National food safety standard beverage》Sampling inspection；
Step 5：Qualified products are packed, warehouse-in.
Wherein, in the step 1, the preparation method of the cornel extractive is comprised the following steps：
Step 1.1：With Fructus Corni as raw material, 24h is soaked with 95% ethanol, the volume of 95% ethanol is 6 times of raw material volume；
Step 1.2：Refluxing extraction 2 times, Extracting temperature is 60 DEG C, and extraction time is 2 h every time；Reflux extracting liquid merges after filtering
Filtrate, concentrates filtrate to the 1/5 of former filtrate volume, then will be centrifuged after gained concentrate aqueous precipitation；
Step 1.3：Precipitation reduced vacuum drying after step 1.2 is centrifuged to moisture is less than 5%, obtains extract A；
Step 1.4：Supernatant decompression after step 1.2 is centrifuged, after being concentrated into the 1/5 of former supernatant volume, inserts medium pole
Property or nonpolarity macroporous adsorptive resins chromatographic column, successively deionized water, 10% ~ 90% ethanol carry out gradient elution, collect eluent, will
Eluent liquid is evaporated to the 1/5 of former effluent volume, and reduced vacuum drying to moisture is less than 5%, obtains extract B；
Step 1.5：Uniform mixed extract A and extract B, cross 100 mesh sieves after crushing, cornel extractive is obtained.
In the step 1, the preparation method of the oyster extract is comprised the following steps：
Step 2.1：With oyster meat as raw material, water extraction operation is carried out, water extraction temperature is 60 DEG C, and extraction time is 2 times；For the first time
Plus the deionized water of 10 times of oyster meat volume extracts 2h, the deionized water that 8 times of oyster meat volume is added for the second time extracts 1.5h；
Step 2.2：Merging filtrate after filtration, vacuum-concentrcted obtains concentrate to the 1/5 of former filtrate volume；
Step 2.3：Concentrate is less than into 5% with spray dryer drying to moisture, transient temperature is dried for 160 ~ 190 DEG C,
Outlet temperature is 85 ~ 100 DEG C；
Step 2.4：Gains are crushed, 100 mesh sieves are crossed, oyster extract is obtained.
In the step 1, the preparation method of the Astragalus Root P.E is comprised the following steps：
Step 3.1：With Radix Astragali medicine materical crude slice as raw material, water extraction operation is carried out, water extraction temperature is 60 DEG C, and extraction time is 2 times；First
The deionized water of secondary plus 10 times of Radix Astragali medicine materical crude slice volume extracts 2h, and the deionized water that 8 times of Radix Astragali medicine materical crude slice volume is added for the second time is extracted
1.5h；
Step 3.2：After merging filtrate, vacuum-concentrcted obtains concentrate to the 1/5 of former filtrate volume；
Step 3.3：Concentrate vacuum decompression drying to moisture is less than into 5%；
Step 3.4：Gains are crushed, 100 mesh sieves are crossed, Astragalus Root P.E is obtained.
In the step 1, the preparation method of the tuckahoe extracts is comprised the following steps：
Step 4.1：With Poria cocos as raw material, peeling is cleaned, and stripping and slicing is dried；
Step 4.2：Alcohol extracting method operation is carried out to the Poria cocos after process, alcohol extracting temperature is 60 DEG C, and extraction time is 2 times；Alcohol extracting is adopted
With the ethanol that concentration is 70%, each 2h, 8 times of 10 times of Poria cocos volume, second plus Poria cocos volume are added for the first time；
Step 4.3：After merging filtrate, vacuum-concentrcted obtains concentrate to the 1/5 of former filtrate volume；
Step 4.4：Concentrate vacuum decompression drying to moisture is less than into 5%；
Step 4.5：Gains are crushed, 100 mesh sieves are crossed, tuckahoe extracts are obtained.
In the step 1, the preparation method of the haw thorn extract is comprised the following steps：
Step 5.1：With leaves of Hawthorn as raw material, meal is ground into；
Step 5.2：Alcohol extracting method operation is carried out to the meal after process, alcohol extracting temperature is 60 DEG C, and extraction time is 2 times；Alcohol extracting is adopted
With the ethanol that concentration is 50%, each 2h, 8 times of 10 times of coarse dispersion product, second plus coarse dispersion product are added for the first time；
Step 5.3：After merging filtrate, insert on macroporous absorbent resin, successively deionized water, the ethanol of 10% ~ 90% concentration are washed
It is de-, and collect eluent；
Step 5.4：Eluent is concentrated into into relative density for 1～1.2 at 60 DEG C；
Step 5.5：Concentrate reduced vacuum drying to moisture is less than into 5%；
Step 5.6：Gains are crushed, 100 mesh sieves are crossed, haw thorn extract is obtained.
In the present invention, if no special instructions, concentration is represented as mass concentration.
Embodiment 2：
A kind of composition for improving osteoarthrosis pain, it is made up of the raw material of following weight portion：It is 18 parts of cornel extractive, male
10 parts of oyster extract, 10 parts of Astragalus Root P.E, 10 parts of tuckahoe extracts, 5 parts of haw thorn extract, 5 parts of Glucosamine, water solubility
35 parts of dietary fiber, 3 parts of mannitol, 4 parts of steviol glycoside.
The present invention for improve osteoarthrosis pain composition preparation method step with embodiment 1.
Embodiment 3：
A kind of composition for improving osteoarthrosis pain, it is made up of the raw material of following weight portion：It is 18 parts of cornel extractive, male
15 parts of oyster extract, 15 parts of Astragalus Root P.E, 15 parts of tuckahoe extracts, 3 parts of haw thorn extract, 5 parts of Glucosamine, water solubility
25 parts of dietary fiber, 4 parts of mannitol, 3 parts of steviol glycoside.
The present invention for improve osteoarthrosis pain composition preparation method step with embodiment 1.
Embodiment 4：
A kind of composition for improving osteoarthrosis pain, it is made up of the raw material of following weight portion：It is 15 parts of cornel extractive, male
13 parts of oyster extract, 13 parts of Astragalus Root P.E, 15 parts of tuckahoe extracts, 4 parts of haw thorn extract, 4 parts of Glucosamine, water solubility
30 parts of dietary fiber, 2 parts of mannitol, 4 parts of steviol glycoside.
The present invention for improve osteoarthrosis pain composition preparation method step with embodiment 1.
Embodiment 5：
A kind of composition for improving osteoarthrosis pain, it is made up of the raw material of following weight portion：It is 18 parts of cornel extractive, male
15 parts of oyster extract, 13 parts of Astragalus Root P.E, 13 parts of tuckahoe extracts, 3 parts of haw thorn extract, 5 parts of Glucosamine, water solubility
25 parts of dietary fiber, 4 parts of mannitol, 4 parts of steviol glycoside.
The present invention for improve osteoarthrosis pain composition preparation method step with embodiment 1.
Example 1～5 prepares respectively different compositions 1～5, carries out clinical testing.
Meet the bone joint pain patient totally 300 of the tested qualification of this test, at 51 ± 5.2 years old age, be randomly divided into experiment
Group 1～5 and control group, 50 per group.Before experiment, experimental group 1～5 and control group crowd's mental status, sleep quality, diet feelings
Condition etc. is basically identical.Control group gives conventional antiinflammatory anodyne.
（1）Group is arranged：Experimental group 1～5：Each 50, male patient 25, female patient 25；Control group：50,
The male sex 25, women 25.
（2）Curative effect is passed judgment on：
Cure：Pain disappears；
It is effective：Pain slows down 50 ~ 90%, and symptom is obviously improved；
Take a turn for the better：Still with pain 20 ~ 49%, symptom makes moderate progress aggravating activities；
It is invalid：Pain still≤20%, symptom is without improvement.
（3）As a result：The treatment results of experimental group 1～5（Recovery from illness+effective for efficient）Show, experimental group is efficient in order
Respectively 93.25%, 92.78%, 91.89%, 91.26%, 91.23%, it is 33.63% that control group is efficient.
（4）It is statistically analyzed that there were significant differences（P ＜ 0.05）, experimental group curative effect substantially high and control group is illustrated, wherein,
The effect optimum of experimental group 1, experimental group and control group ordinary circumstance, without significant difference, meet comparativity.
Claims (9)
1. a kind of composition for improving osteoarthrosis pain, it is characterised in that：The composition by following weight portion component group
Into：15 ~ 20 parts of cornel extractive, 10 ~ 15 parts of oyster extract, 10 ~ 15 parts of Astragalus Root P.E, 10 ~ 15 parts of tuckahoe extracts,
3 ~ 5 parts of haw thorn extract, 3 ~ 5 parts of Glucosamine, 25 ~ 35 parts of water-soluble dietary fiber, 6 ~ 8 parts of sweetener.
2. a kind of composition for improving osteoarthrosis pain according to claim 1, it is characterised in that：The water-soluble meals
Food fiber is the mixing of one or more in FOS, oligoisomaltose, xylo-oligosaccharide, polydextrose.
3. a kind of composition for improving osteoarthrosis pain according to claim 1, it is characterised in that：The sweetener is
Mannitol, one or more of steviol glycoside of mixing.
4. the preparation method for improving the composition of osteoarthrosis pain described in a kind of one of employing claims 1 to 3, its feature
It is：The preparation method is comprised the following steps：
Step 1：Taking Fructus Corni, oyster, the Radix Astragali, Poria cocos, leaves of Hawthorn carries out extract preparation, and cornel extractive, oyster is obtained
Extract, Astragalus Root P.E, tuckahoe extracts, haw thorn extract；
Step 2：Take cornel extractive, oyster extract, Astragalus Root P.E, tuckahoe extracts, haw thorn extract, aminoglucose
Sugar, water-soluble dietary fiber and sweetener, are well mixed by component；
Step 3：Carried out with fully automatic powder bottle placer in dust proof workshop filling；
Step 4：According to GB 7101《National food safety standard beverage》Sampling inspection；
Step 5：Qualified products are packed, warehouse-in.
5. a kind of preparation method for improving the composition of osteoarthrosis pain according to claim 4, it is characterised in that：Institute
In stating step 1, the preparation method of the cornel extractive is comprised the following steps：
Step 1.1：With Fructus Corni as raw material, 24h is soaked with 95% ethanol, the volume of 95% ethanol is 6 times of raw material volume；
Step 1.2：Refluxing extraction 2 times, Extracting temperature is 60 DEG C, and extraction time is 2 h every time；Reflux extracting liquid merges after filtering
Filtrate, concentrates filtrate to the 1/5 of former filtrate volume, then will be centrifuged after gained concentrate aqueous precipitation；
Step 1.3：Precipitation reduced vacuum drying after step 1.2 is centrifuged to moisture is less than 5%, obtains extract A；
Step 1.4：Supernatant decompression after step 1.2 is centrifuged, after being concentrated into the 1/5 of former supernatant volume, inserts medium pole
Property or nonpolarity macroporous adsorptive resins chromatographic column, successively deionized water, 10% ~ 90% ethanol carry out gradient elution, collect eluent, will
Eluent liquid is evaporated to the 1/5 of former effluent volume, and reduced vacuum drying to moisture is less than 5%, obtains extract B；
Step 1.5：Uniform mixed extract A and extract B, cross 100 mesh sieves after crushing, cornel extractive is obtained.
6. a kind of preparation method for improving the composition of osteoarthrosis pain according to claim 4, it is characterised in that：Institute
In stating step 1, the preparation method of the oyster extract is comprised the following steps：
Step 2.1：With oyster meat as raw material, water extraction operation is carried out, water extraction temperature is 60 DEG C, and extraction time is 2 times；For the first time
Plus the deionized water of 10 times of oyster meat volume extracts 2h, the deionized water that 8 times of oyster meat volume is added for the second time extracts 1.5h；
Step 2.2：Merging filtrate after filtration, vacuum-concentrcted obtains concentrate to the 1/5 of former filtrate volume；
Step 2.3：Concentrate is less than into 5% with spray dryer drying to moisture, transient temperature is dried for 160 ~ 190 DEG C,
Outlet temperature is 85 ~ 100 DEG C；
Step 2.4：Gains are crushed, 100 mesh sieves are crossed, oyster extract is obtained.
7. a kind of preparation method for improving the composition of osteoarthrosis pain according to claim 4, it is characterised in that：Institute
In stating step 1, the preparation method of the Astragalus Root P.E is comprised the following steps：
Step 3.1：With Radix Astragali medicine materical crude slice as raw material, water extraction operation is carried out, water extraction temperature is 60 DEG C, and extraction time is 2 times；First
The deionized water of secondary plus 10 times of Radix Astragali medicine materical crude slice volume extracts 2h, and the deionized water that 8 times of Radix Astragali medicine materical crude slice volume is added for the second time is extracted
1.5h；
Step 3.2：After merging filtrate, vacuum-concentrcted obtains concentrate to the 1/5 of former filtrate volume；
Step 3.3：Concentrate vacuum decompression drying to moisture is less than into 5%；
Step 3.4：Gains are crushed, 100 mesh sieves are crossed, Astragalus Root P.E is obtained.
8. a kind of preparation method for improving the composition of osteoarthrosis pain according to claim 4, it is characterised in that：Institute
In stating step 1, the preparation method of the tuckahoe extracts is comprised the following steps：
Step 4.1：With Poria cocos as raw material, peeling is cleaned, and stripping and slicing is dried；
Step 4.2：Alcohol extracting method operation is carried out to the Poria cocos after process, alcohol extracting temperature is 60 DEG C, and extraction time is 2 times；Alcohol extracting is adopted
With the ethanol that concentration is 70%, each 2h, 8 times of 10 times of Poria cocos volume, second plus Poria cocos volume are added for the first time；
Step 4.3：After merging filtrate, vacuum-concentrcted obtains concentrate to the 1/5 of former filtrate volume；
Step 4.4：Concentrate vacuum decompression drying to moisture is less than into 5%；
Step 4.5：Gains are crushed, 100 mesh sieves are crossed, tuckahoe extracts are obtained.
9. a kind of preparation method for improving the composition of osteoarthrosis pain according to claim 4, it is characterised in that：Institute
In stating step 1, the preparation method of the haw thorn extract is comprised the following steps：
Step 5.1：With leaves of Hawthorn as raw material, meal is ground into；
Step 5.2：Alcohol extracting method operation is carried out to the meal after process, alcohol extracting temperature is 60 DEG C, and extraction time is 2 times；Alcohol extracting is adopted
With the ethanol that concentration is 50%, each 2h, 8 times of 10 times of coarse dispersion product, second plus coarse dispersion product are added for the first time；
Step 5.3：After merging filtrate, insert on macroporous absorbent resin, successively deionized water, the ethanol of 10% ~ 90% concentration are washed
It is de-, and collect eluent；
Step 5.4：Eluent is concentrated into into relative density for 1～1.2 at 60 DEG C；
Step 5.5：Concentrate reduced vacuum drying to moisture is less than into 5%；
Step 5.6：Gains are crushed, 100 mesh sieves are crossed, haw thorn extract is obtained.
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| CN201710081414.5A Pending CN106619877A (en) | 2017-02-15 | 2017-02-15 | Composition for relieving bone joint pain, and preparation method of composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114601920A (en) * | 2022-03-23 | 2022-06-10 | 宁波御坊堂生物科技有限公司 | Oral liposome composition for improving bone joint health and preparation method thereof |
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2017
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114601920A (en) * | 2022-03-23 | 2022-06-10 | 宁波御坊堂生物科技有限公司 | Oral liposome composition for improving bone joint health and preparation method thereof |
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Effective date of registration: 20180522 Address after: 200030 Meilong Road, Xuhui District, Xuhui District, Shanghai Applicant after: He Hongyan Address before: 310012 room 2, unit 8, 49 Xihu District Road, Hangzhou, Zhejiang, 205. Applicant before: Wang Weiyi |
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