CN106619334A - Plant extract with anti-allergy, anti-inflammation and post-basking repairing functions as well as preparation method and application thereof - Google Patents
Plant extract with anti-allergy, anti-inflammation and post-basking repairing functions as well as preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention relates to plant extract with anti-allergy, anti-inflammation and post-basking repairing functions as well as a preparation method and application thereof. The plant extract is prepared by taking a rice fermented solution, a parslane herb extracting solution, a radix sophorae extracting solution and a chondrus crispus extract as raw materials and mixing at a proper weight ratio. The prepared plant extract has good anti-inflammation and swelling-resisting effects, and the swelling inhibition rate reaches 69.33 percent; the plant extract has anti-allergy and skin relaxing effects and also has the effects of reducing skin moisture loss and repairing skin barriers; the plant extract can be used for supplementing moisture and moisturizing, warming skin and alleviating skin redness, has a repairing effect on post-basking skin and has no side effect; the plant extract can be used as an additive with the anti-allergy, anti-inflammation and post-basking repairing functions, and has a wide application prospect.
Description
Technical field
The invention belongs to technical field of skin care, and in particular to a kind of plant extract of antiallergic antiinflammatory after-sun and its
Preparation method and application.
Background technology
The precise meaning of sensitive skin is not yet reached an agreement.It is generally acknowledged that sensitive skin is a kind of height not tolerating
Skin condition, be vulnerable to various factors excitation and produce twinge, burn, the multiple-factor synthesis of the subjective symptom such as tight, prurituss
Disease, skin appearance is normally or with slight desquamation, erythema and drying.
Sensitive skin is two different concepts from " skin allergy ", and skin allergy is a kind of allergy, by allergic effect
Original is entered after body, promotes body to produce corresponding antibody, causes antigen antibody reaction, is shown as erythema, pimple, welt etc. and is faced
Bed objective sign, often with prurituss.And toleration of the sensitive skin typically to stimulating is reduced, there are a series of abnormal sensories anti-
Should, objective sign is lacked mostly, although its genesis mechanism is not very clear, but generally believes without immunity or allergy mechanism.
Process to general sensitive skin, is to avoid stimulating again first, reduces as far as possible and steams the U.S.s such as face, massage, exfoliation
Appearance measure.The cosmetics for sensitive skin design are can select, it is often containing vitamin B5, carboxymethyl R-glucan etc..By
It is relatively dry in skin, the moisturizer containing proper ratio lipid can be used.During daily skin nursing, three below base is adhered to
This principle：Using the abluent and wetting agent of gentle, non-stimulated composition；Skin is kept to have the water for maintaining healthy cutin layer function
Point；Reinforce skin barrier function.
By means of biomedical engineering technology, with non invasive technique measurement biophysical parameters skin small degree is evaluated
Change, such as with the moisture of skin evaporation measuring instrument measurement transepidermal fluid loss of skin, silica gel is replicated and squama measuring instrument is evaluated
Skin two dimension or three-dimensional surface structure, skin colourity spectroscope measurement skin color, laser Doppler flowmetry measurement skin blood
Stream situation, A-mode ultrasonic apparatus check that epidermis, corium and hypodermic thickness change.Measurement skin Jing epidermis fluid losses are most Jing
The index of allusion quotation.
Skin water loss tester has humidity and temperature sensor, and the Concentraton gradient of skin surface moisture evaporation can be entered
Row measurement, its result is represented with TEWL values.TEWL values are decided by the integrity of skin barrier function.Sensitive skin person's skin screen
Barrier function is imperfect, therefore facial basis TEWL values are high compared with normal skin.
Moisture is the maximum material of dielectric constant on skin.Therefore, when moisture changes, the capacitance of skin
Change simultaneously, this change can be measured by epidermis water content detecting instrument, so as to reflect the water content of skin indirectly.
Sensitive skin person face basis epidermis water content is low compared with normal skin.
Therefore by the improvement of the index such as evaluation and test sample replenishing water and preserving moisture, function, the skin erythema of reparation skin barrier,
Can be with comprehensive evaluating sample moisturizing, moisturizing, stimulation of releiving, the effect of gentle skin.
Antiallergic skin care item of the prior art all contain a certain amount of chemical composition, for skin has certain injury, together
When for anaphylaxis skin quality, some chemical elements are likely to cause allergy so as to the burden of more pipe skin.Therefore in the urgent need to
Develop some pure naturals, antiallergic antiphlogistic effects are good, have no side effect or Small side effects plant extract compound recipe.
The content of the invention
In order to solve the problems referred to above of prior art presence, the invention provides a kind of plant of antiallergic antiinflammatory after-sun
Extract and its preparation method and application.There is the plant extract anti-inflammation detumescence, antiallergic to releive stimulation, replenishing water and preserving moisture, gentle
Effect of skin, while also reaching the effect of reparation to skin after solarization, has no side effect, can be used as skin care item antiallergic antiinflammatory, solarization
The functional additive repaired afterwards, is with a wide range of applications.
The technical solution adopted in the present invention is：
A kind of plant extract of antiallergic antiinflammatory after-sun, raw material components include：
Rice fermentation liquid, 2-4 weight portions；
Herba Portulacae extract, 2-4 weight portions；
Radix sophorae extracting solution, 2-4 weight portions；
Chondrus crispus extract, 4-6 weight portions.
The rice fermentation liquid is adopted and prepared with the following method：
(A1) rice is taken, after soaking, is cooked, obtain processed rice；
(A2) aspergillus oryzae is inoculated with processed rice described in step (A1), the inoculation quality of the aspergillus oryzae accounts for described ripe
The 1-3% of rice milling meal quality, afterwards temperature be 30-33 DEG C, humidity be 55-65% under conditions of carry out cultivation 48-32h, Jing
Centrifugation, filtration, obtain final product the rice fermentation liquid.
In step (A1), the soak time is 10-15h.
The Herba Portulacae extract is adopted and prepared with the following method：
(B1) Herba Portulacae is taken, slurry is broken into after peeling, obtain Herba Portulacae serosity；
(B2) distilled water is added for the first time in the Herba Portulacae serosity in step (B1), after immersion 12-14h, at 95-98 DEG C
Decoction 1.5-3.5h is carried out, centrifugation, filtration obtain the first filtrate and the first filtering residue；Second addition in first filtering residue
Distilled water simultaneously carries out decoction 1.5-3.5h at 95-98 DEG C, centrifugation, filtration, obtains the second filtrate and the second filtering residue；By described first
Filtrate merges with the second filtrate, and concentration to be removed and carry out microporous filter after distilled water, obtains final product the Herba Portulacae extract.
In step (B2), the Herba Portulacae serosity is 1 with the mass ratio of addition distilled water for the first time:3-1:5；It is described
First filtering residue is 1 with the mass ratio of second addition distilled water:3-1:5.
In step (B2), the concentration is water-bath concentration, and the temperature of the concentration is 85-95 DEG C, carries out the micropore mistake
The filter sizes of filter are 0.4-0.5 μm.
The radix sophorae extracting solution is adopted and prepared with the following method：
(C1) radix sophorae is taken, drying, crushing obtain radix sophorae fine powder；
(C2) distilled water is added for the first time in the radix sophorae fine powder in step (C1), after immersion 20-40min, in 90-95
DEG C carry out reflux, extract, 1-2h, centrifugation, filter, obtain the first filtrate and the first filtering residue；Add with second to first filtering residue
Enter distilled water and reflux, extract, 1-2h is carried out at 90-95 DEG C, centrifugation, filtration obtain the second filtrate and the second filtering residue；By described
One filtrate merges with the second filtrate, and concentration to be removed and carry out microporous filter after distilled water, obtains final product the radix sophorae extracting solution.
In step (C1), the particle diameter of the radix sophorae fine powder is 35-45 mesh；
In step (C2), the radix sophorae fine powder is 1 with the mass ratio of addition distilled water for the first time:18-1:22；Described
One filtering residue is 1 with the mass ratio of second addition distilled water:18-1:22；
The concentration is water-bath concentration, and the temperature of the concentration is 85-95 DEG C, carries out the filter sizes of the microporous filter
For 0.4-0.5 μm.
The preparation method of the plant extract of described antiallergic antiinflammatory after-sun, concretely comprises the following steps：
After taking the rice fermentation liquid, Herba Portulacae extract and radix sophorae extracting solution respectively and being mixed, ripple is added
Chondrus extract, is sufficiently mixed uniformly, obtains final product the plant extract.
Application of the plant extract in the skin care item for preparing antiallergic antiinflammatory after-sun.
Beneficial effects of the present invention are：
The plant extract of antiallergic antiinflammatory after-sun of the present invention, by being carried using rice fermentation liquid, Herba Portulacae
Liquid, radix sophorae extracting solution and Chondrus crispus extract are taken for raw material and carries out being adapted to weight proportion, the plant for preparing carries
Take thing and there is the anti-swollen effect of good antiinflammatory, inhibitory rate of intumesce is up to 69.33%；With antiallergic releive skin, reduce skin water
Effect of skin barrier is lost, is repaired in shunting, and replenishing water and preserving moisture, gentle skin alleviates skin rubefaction, while also reaching to skin after solarization
The effect of reparation, has no side effect, and can answer with extensive as skin care item antiallergic antiinflammatory, the functional additive of after-sun
Use prospect.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical scheme will be carried out below
Detailed description.Obviously, described embodiment is only a part of embodiment of the invention, rather than the embodiment of whole.Base
Embodiment in the present invention, those of ordinary skill in the art are resulting on the premise of creative work is not made to be owned
Other embodiment, belongs to the scope that the present invention is protected.
1mg is represented with 1 weight portion in example below.
Embodiment 1
The present embodiment provides a kind of plant extract of antiallergic antiinflammatory after-sun, and raw material components include：
Rice fermentation liquid, 2 weight portions；
Herba Portulacae extract, 4 weight portions；
Radix sophorae extracting solution, 2 weight portions；
Chondrus crispus extract (offer of Shanghai Lu Ya Bioisystech Co., Ltd), 6 weight portions.
Further, the preparation method of the plant extract of the antiallergic antiinflammatory after-sun, comprises the following steps that：
(1) rice fermentation liquid is prepared
(A1) rice is taken, adds 1 times of quality water to carry out after immersion 15h, cooking, obtain processed rice；
(A2) aspergillus oryzae (Japanese brewery industry Co., Ltd. provides), institute are inoculated with processed rice described in step (A1)
The inoculation quality for stating aspergillus oryzae accounts for the 1% of the processed rice quality, afterwards temperature be 30 DEG C, humidity be 55% under conditions of
Cultivation 32h is carried out, Jing centrifugations, filtration obtain final product the rice fermentation liquid；
(2) Herba Portulacae extract is prepared
(B1) Herba Portulacae is taken, ultraviolet-sterilization after peeling, and slurry is broken into, obtain Herba Portulacae serosity；
(B2) add distilled water for the first time in the Herba Portulacae serosity in step (B1) and control the Herba Portulacae serosity with
The mass ratio of addition distilled water is 1:3, after immersion 12h, carry out decoction 3.5h at 95 DEG C, centrifugation, filter, obtain the first filtrate and
First filtering residue；
Add distilled water for the second time in first filtering residue and control first filtering residue with second addition distilled water
Mass ratio be 1:3, carry out decoction 3.5h at 95 DEG C afterwards, centrifugation, filtration obtain the second filtrate and the second filtering residue；
First filtrate is merged with the second filtrate, concentration is carried out under 85 DEG C of water bath conditions and is removed distilled water, Zhi Houyong
Aperture carries out microporous filter for 0.4 μm of filter membrane, obtains final product the Herba Portulacae extract；
(3) radix sophorae extracting solution is prepared
(C1) radix sophorae is taken, drying, crushing obtain the radix sophorae fine powder that particle diameter is 35 mesh；
(C2) add distilled water for the first time in the radix sophorae fine powder in step (C1) and control the radix sophorae fine powder with
For the first time the mass ratio of addition distilled water is 1:18, after immersion 20min, reflux, extract, 2h is carried out at 90 DEG C, centrifugation, filtration are obtained
To the first filtrate and the first filtering residue；
Add distilled water for the second time in first filtering residue and control first filtering residue with second addition distilled water
Mass ratio be 1:18, carry out reflux, extract, 2h at 90 DEG C afterwards, centrifugation, filtration obtain the second filtrate and the second filtering residue；
First filtrate is merged with the second filtrate, concentration is carried out under 85 DEG C of water bath conditions and is removed distilled water, Zhi Houyong
Aperture carries out microporous filter for 0.4 μm of filter membrane, obtains final product the radix sophorae extracting solution；
(4) after taking the rice fermentation liquid Herba Portulacae extract and radix sophorae extracting solution respectively and being mixed, wrinkle is added
Ripple chondrus extract, is sufficiently mixed uniformly, obtains final product the plant extract.
Embodiment 2
The present embodiment provides a kind of plant extract of antiallergic antiinflammatory after-sun, and raw material components include：
Rice fermentation liquid, 4 weight portions；
Herba Portulacae extract, 2 weight portions；
Radix sophorae extracting solution, 4 weight portions；
Chondrus crispus extract, 4 weight portions.
Further, the preparation method of the plant extract of the antiallergic antiinflammatory after-sun, comprises the following steps that：
(1) rice fermentation liquid is prepared
(A1) rice is taken, adds 2 times of quality water to carry out after immersion 15h, cooking, obtain processed rice；
(A2) aspergillus oryzae (Japanese brewery industry Co., Ltd. provides), institute are inoculated with processed rice described in step (A1)
The inoculation quality for stating aspergillus oryzae accounts for the 3% of the processed rice quality, afterwards temperature be 33 DEG C, humidity be 65% under conditions of
Cultivation 48h is carried out, Jing centrifugations, filtration obtain final product the rice fermentation liquid；
(2) Herba Portulacae extract is prepared
(B1) Herba Portulacae is taken, ultraviolet-sterilization after peeling, and slurry is broken into, obtain Herba Portulacae serosity；
(B2) add distilled water for the first time in the Herba Portulacae serosity in step (B1) and control the Herba Portulacae serosity with
The mass ratio of addition distilled water is 1:5, after immersion 14h, carry out decoction 1.5h at 98 DEG C, centrifugation, filter, obtain the first filtrate and
First filtering residue；
Add distilled water for the second time in first filtering residue and control first filtering residue with second addition distilled water
Mass ratio be 1:5, carry out decoction 1.5h at 98 DEG C afterwards, centrifugation, filtration obtain the second filtrate and the second filtering residue；
First filtrate is merged with the second filtrate, concentration is carried out under 95 DEG C of water bath conditions and is removed distilled water, Zhi Houyong
Aperture carries out microporous filter for 0.5 μm of filter membrane, obtains final product the Herba Portulacae extract；
(3) radix sophorae extracting solution is prepared
(C1) radix sophorae is taken, drying, crushing obtain the radix sophorae fine powder that particle diameter is 45 mesh；
(C2) add distilled water for the first time in the radix sophorae fine powder in step (C1) and control the radix sophorae fine powder with
For the first time the mass ratio of addition distilled water is 1:22, after immersion 40min, reflux, extract, 1h is carried out at 95 DEG C, centrifugation, filtration are obtained
To the first filtrate and the first filtering residue；
Add distilled water for the second time in first filtering residue and control first filtering residue with second addition distilled water
Mass ratio be 1:22, carry out reflux, extract, 1h at 95 DEG C afterwards, centrifugation, filtration obtain the second filtrate and the second filtering residue；
First filtrate is merged with the second filtrate, concentration is carried out under 95 DEG C of water bath conditions and is removed distilled water, Zhi Houyong
Aperture carries out microporous filter for 0.5 μm of filter membrane, obtains final product the radix sophorae extracting solution；
(4) after taking the rice fermentation liquid, Herba Portulacae extract and radix sophorae extracting solution respectively and being mixed, wrinkle is added
Ripple chondrus extract, is sufficiently mixed uniformly, obtains final product the plant extract.
Embodiment 3
The present embodiment provides a kind of plant extract of antiallergic antiinflammatory after-sun, and raw material components include：
Rice fermentation liquid, 3 weight portions；
Herba Portulacae extract, 3 weight portions；
Radix sophorae extracting solution, 3 weight portions；
Chondrus crispus extract, 5 weight portions.
Further, the preparation method of the plant extract of the antiallergic antiinflammatory after-sun, comprises the following steps that：
(1) rice fermentation liquid is prepared
(A1) rice is taken, adds 1-2 times of quality water to carry out after immersion 10-15h, cooking, obtain processed rice；
(A2) aspergillus oryzae (Japanese brewery industry Co., Ltd. provides), institute are inoculated with processed rice described in step (A1)
The inoculation quality for stating aspergillus oryzae accounts for the 1-3% of the processed rice quality, afterwards temperature be 30-33 DEG C, humidity be 55-65%
Under conditions of carry out cultivation 48-32h, Jing centrifugations, filter, obtain final product the rice fermentation liquid；
(2) Herba Portulacae extract is prepared
(B1) Herba Portulacae is taken, ultraviolet-sterilization after peeling, and slurry is broken into, obtain Herba Portulacae serosity；
(B2) add distilled water for the first time in the Herba Portulacae serosity in step (B1) and control the Herba Portulacae serosity with
The mass ratio of addition distilled water is 1:3-1:5, after immersion 12-14h, decoction 1.5-3.5h is carried out at 95-98 DEG C, it is centrifuged, filters,
Obtain the first filtrate and the first filtering residue；
Add distilled water for the second time in first filtering residue and control first filtering residue with second addition distilled water
Mass ratio be 1:3-1:5, carry out decoction 1.5-3.5h at 95-98 DEG C afterwards, centrifugation, filtration obtain the second filtrate and second
Filtering residue；
First filtrate is merged with the second filtrate, concentration is carried out under 85-95 DEG C of water bath condition and is removed distilled water, afterwards
It is that 0.4-0.5 μm of filter membrane carries out microporous filter with aperture, obtains final product the Herba Portulacae extract；
(3) radix sophorae extracting solution is prepared
(C1) radix sophorae is taken, drying, crushing obtain the radix sophorae fine powder that particle diameter is 40 mesh；
(C2) add distilled water for the first time in the radix sophorae fine powder in step (C1) and control the radix sophorae fine powder with
For the first time the mass ratio of addition distilled water is 1:20, after immersion 30min, reflux, extract, 1.5h is carried out at 92 DEG C, it is centrifuged, filters,
Obtain the first filtrate and the first filtering residue；
Add distilled water for the second time in first filtering residue and control first filtering residue with second addition distilled water
Mass ratio be 1:20, carry out reflux, extract, 1.5h at 92 DEG C afterwards, centrifugation, filtration obtain the second filtrate and the second filtering residue；
First filtrate is merged with the second filtrate, concentration is carried out under 90 DEG C of water bath conditions and is removed distilled water, Zhi Houyong
Aperture carries out microporous filter for 0.45 μm of filter membrane, obtains final product the radix sophorae extracting solution；
(4) after taking the rice fermentation liquid, Herba Portulacae extract and radix sophorae extracting solution respectively and being mixed, wrinkle is added
Ripple chondrus extract, is sufficiently mixed uniformly, obtains final product the plant extract.
Experimental example
1st, prepared by laboratory sample
Using basic components (glycerol stearic acid ester 2wt%, cetearyl alcohol 3wt%, glycerol 5wt%, butanediol
10wt%, hydrogenated polydecene 6wt%, olive oil 4wt%, ceteth -20 are 1wt%, sodium lauryl sulfate
0.5wt%, carbomer 0.2wt%, xanthan gum 0.3wt%, sodium hydroxide 0.1wt%, phenoxyethanol 1.0wt%, deionized water
Surplus) as carrier, it is respectively that rice fermentation liquid, Herba Portulacae extract, radix sophorae extracting solution, Chondrus crispus extract is (single
One component) and embodiment 3 described in plant extract and basic components compounded after (wherein one-component or the plant
Extract accounts for the mass fraction of basic components and is 2wt%), sample liquid A, sample liquid B, sample liquid C, sample liquid D, sample is obtained
Liquid E, carries out respectively afterwards the measurement in terms of anti-inflammation test, antiallergic (stimulation of releiving) test, after-sun.
2nd, anti-inflammation test
It is subjects to take mice, and male and female are more than half, is randomly divided into 3 groups, 10 per group, chooses distilled water as blank
Group, concentration for 0.05mg/ml ibuprofen as ibuprofen matched group, take respectively afterwards blank control group, ibuprofen matched group,
Sample liquid A-E carries out the continuous 3d of gastric infusion to each group mice.After last dose 30min, in mouse right ear uniform application two
Only, left ear is not applied as control the μ l/ of toluene 50, and after proinflammatory effect 30min mice is put to death, and cuts ears auricle, with diameter 8mm's
Card punch lays auricle in ears same position, and claims its quality.Calculate swelling and inhibitory rate of intumesce.
Swelling=auris dextra tablet quality-left auricle quality
Inhibitory rate of intumesce %=(the average swelling of the average swelling-administration group of blank control group)/blank control group is average
Swelling * 100%
Measurement result is as shown in table 1.
The impact of table 1- difference sample liquid xylol mice swelling
| Sample liquid | Swelling | Inhibitory rate of intumesce % |
| A | 8.54 | 56.35 |
| B | 8.08 | 58.30 |
| C | 3.38 | 60.21 |
| D | 8.35 | 55.26 |
| E | 6.00 | 69.33 |
| Blank control group | 19.56 | - |
| Ibuprofen matched group | 6.68 | 65.85 |
Although from table 1 it follows that rice fermentation liquid, Herba Portulacae extract, radix sophorae extracting solution, Chondrus crispus are carried
Take thing (sample liquid A-D) and there is certain effect, but the present invention formed after above-mentioned each component is carried out being combined to eliminating swelling
The inhibitory rate of intumesce of the plant extract (sample liquid E) exceed ibuprofen matched group, up to 69.33%.
3rd, antiallergic (stimulation of releiving) test
(1) volunteer requires：
18～35 years old age normal subjectses, sex is random；Without serious systemic disease, without immunodeficiency or autoimmune
Property disease patient；No active anaphylactic disease person；Previously to skin-care cosmetics without allergies；Whole body is not used in nearly January
Hormone medicine and immunosuppressant person；Laser beautifying or Chemical peeling were not done in nearly 2 years；Other clinical trials are not participated in
Person；Aspiration is participated in and can complete specified content person by test requirements document；The face skin person of drying, and skin tolerance level difference person.
(2) EXPERIMENTAL DESIGN：
Select sample liquid C (basic components+account for the sample liquid that basic components 2wt% radix sophorae extracting solution is made into), sample liquid E
(basic components+account for the sample liquid that the gained plant extract of basic components 2wt% embodiments 3 is made into) are used as sample liquid, experimenter
Side face uses sample liquid, and used as control, contrast experimenter uses before and after product and relative comparison group opposite side, skin physiology
The change of index.
Experimenter fills in Informed Consent Form and skin condition questionnaire.Test same day recipient site does not use any cosmetics.
Experimenter's clean water recipient site, sits quietly in constant-temperature constant-humidity environment (2222 DEG C of temperature, relative humidity 50%25%RH)
30min.Random group forming criterion, the side face of experimenter is set to experimental group, opposite side and is set to matched group.
Laboratory technician carries out skin data collection to experimenter's face；Stimulate skin 15min using lactic acid, and carry out data and adopt
Collection.
Experimenter smears experimental group sample and control sample according to test zone, and in smearing sample 30min, 1h, 2h
Data acquisition is carried out to test zone with after 4h.
Using t inspections or rank test, change of the experimenter using skin index before and after sample is analyzed, inspection level α=
0.05。
(3) testing process
A. skin surface water loss (TEWL values) test
Skin surface water loss is tested using TewameterTM300.Test zone is cheek, each test
Area tests 3 times and averages, and test result is as shown in table 2.
B. skin moisture content (MMV values) test
After the completion of skin surface water loss test, skin moisture content is carried out using Corneometer CM 825
Test.Test zone is cheek, and each test section is tested 5 times and averaged, and test result is as shown in table 3.
C. skin colourity (a values) test
Subjects skin's colourity a value is tested using MPA 9＆CL 400.Test zone is cheek, each test section
Test 3 times, test result is as shown in table 4.
(4) test result analysis
Percutaneous moisture loss TEWL value changes were reflected in test period, and Experimental Area moisture loss changes over rule
Rule.Its value is less, and moisture loss is fewer, and water lock ability is stronger；Conversely, water lock ability is weaker.
Table 2- uses the statistical result of different sample liquid anteroposterior diameter skin water loss TEWL values
Note：Replaced with "/" for vacancy in table 2, "-" represents P>0.05, " * " represents P<0.05, " * * " represents P<0.01.
As can be seen from Table 2, experimenter smears lactic acid and stimulates after skin, and skin barrier function is destroyed, and percutaneous moisture dissipates
Vector substantially rises, and, using after sample, TEWL values decline for sample liquid C and sample liquid E test zone, wherein, using sample liquid E
Skin percentage of water loss be significantly lower than sample liquid C, illustrate sample liquid E releive skin irritation, reduction percutaneous moisture loss effect it is bright
Aobvious to be better than sample liquid C, i.e., " sample liquid containing the gained plant extract of embodiment 3 " is to reducing percutaneous water loss, repairing skin
Barrier has good effect, and will be apparently higher than the reduction percutaneous moisture loss of " only containing the sample liquid of radix sophorae extracting solution "
Effect.
Skin moisture content MMV value changes were reflected in test period, and Experimental Area moisture changes over rule.
Its value is bigger, and moisture is bigger, conversely, moisture is less.
Table 3- uses the statistical result of moisture of skin MMV values before and after test sample
Note：Replaced with "/" for vacancy in table 3, "-" represents P>0.05, " * " represents P<0.05, " * * " represents P<0.01.
As can be seen from Table 3, experimenter smears lactic acid stimulates the rising of moisture MMV value, sample liquid C and sample after skin
Using after sample, skin moisture content MMV value is above using front liquid E test zones, wherein, using the skin water of sample liquid E
Conjunction rate (i.e. MMV value changes rate) is significantly higher than sample liquid C, illustrates the replenishing water and preserving moisture effect is significant of sample liquid E higher than sample liquid C,
I.e. within experimental period, " sample liquid containing the gained plant extract of embodiment 3 " has good effect to skin moisture-keeping moisturizing,
And will be apparently higher than " only containing the sample liquid of radix sophorae extracting solution " to skin moisture-keeping moisturizing effect.
Skin colourity (a values) characterizes red-green balance, is worth bigger, color more deflection redness, conversely, deflection green.
Table 4- uses the statistical result of skin colourity a value before and after different sample liquid
Note：Replaced with "/" for vacancy in table 4, "-" represents P>0.05, " * " represents P<0.05, " * * " represents P<0.01.
As can be seen from Table 4, experimenter smears lactic acid and stimulates after skin, and skin colourity a value substantially rises, sample liquid C with
Sample liquid E test zone using after sample, a values be below using it is front, wherein, using the alleviation skin rubefaction of sample liquid E, reduction
The effect of skin colourity a value, hence it is evident that higher than sample liquid C, i.e., the " sample containing the gained plant extract of embodiment 3 within experimental period
Product liquid " has good effect to alleviating skin rubefaction, and will be apparently higher than " only containing the sample liquid of radix sophorae extracting solution " to slow
Effect of solution skin rubefaction.
4th, after-sun test
The volunteer of 10 skin sunburns of screening, face is rubescent, sore, in the case of without other skin care item, adheres to
With clear water cleaning face, with sample liquid E (basic components+account for what the gained plant extract of basic components 2wt% embodiments 3 was made into
Sample liquid) face is applied to, after 30min, face skin redness can be clearly visible and weakened, after adhering to sooner or later each daily use once, 5
It is basic to recover after it；So as to illustrate that plant extract of the present invention has good repair to skin after solarization.
The above, the only specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, all should contain
Cover within protection scope of the present invention.Therefore, protection scope of the present invention should be defined by the scope of the claims.
Claims (10)
1. a kind of plant extract of antiallergic antiinflammatory after-sun, it is characterised in that raw material components include：
Rice fermentation liquid, 2-4 weight portions；
Herba Portulacae extract, 2-4 weight portions；
Radix sophorae extracting solution, 2-4 weight portions；
Chondrus crispus extract, 4-6 weight portions.
2. the plant extract of antiallergic antiinflammatory after-sun according to claim 1, it is characterised in that the rice fermentation
Liquid is adopted and prepared with the following method：
(A1) rice is taken, after soaking, is cooked, obtain processed rice；
(A2) aspergillus oryzae is inoculated with processed rice described in step (A1), the inoculation quality of the aspergillus oryzae accounts for the processed rice
The 1-3% of meal quality, afterwards temperature be 30-37 DEG C, humidity be 55-65% under conditions of carry out cultivation 48-72h, Jing centrifugations,
Filter, obtain final product the rice fermentation liquid.
3. the plant extract of antiallergic antiinflammatory after-sun according to claim 2, it is characterised in that in step (A1),
The soak time is 10-15h.
4. the plant extract of antiallergic antiinflammatory after-sun according to claim 1, it is characterised in that the Herba Portulacae carries
Take liquid and adopt and prepare with the following method：
(B1) Herba Portulacae is taken, slurry is broken into after peeling, obtain Herba Portulacae serosity；
(B2) add distilled water for the first time in the Herba Portulacae serosity in step (B1), after immersion 12-14h, carry out at 95-98 DEG C
1.5-3.5h is decocted, centrifugation, filtration obtain the first filtrate and the first filtering residue；Second addition distillation in first filtering residue
Water simultaneously carries out decoction 1.5-3.5h at 95-98 DEG C, centrifugation, filtration, obtains the second filtrate and the second filtering residue；By first filtrate
Merge with the second filtrate, concentration to be removed and carry out microporous filter after distilled water, obtains final product the Herba Portulacae extract.
5. the plant extract of antiallergic antiinflammatory after-sun according to claim 4, it is characterised in that in step (B2),
The Herba Portulacae serosity is 1 with the mass ratio of addition distilled water for the first time:3-1:5；First filtering residue with add for the second time
Plus the mass ratio of distilled water is 1:3-1:5.
6. the plant extract of antiallergic antiinflammatory after-sun according to claim 4, it is characterised in that in step (B2),
The concentration is water-bath concentration, and the temperature of the concentration is 85-95 DEG C, and the filter sizes for carrying out the microporous filter are 0.4-
0.5μm。
7. the plant extract of antiallergic antiinflammatory after-sun according to claim 1, it is characterised in that the radix sophorae is carried
Take liquid and adopt and prepare with the following method：
(C1) radix sophorae is taken, drying, crushing obtain radix sophorae fine powder；
(C2) add distilled water for the first time in the radix sophorae fine powder in step (C1), after immersion 20-40min, enter at 90-95 DEG C
Row reflux, extract, 1-2h, centrifugation, filtration, obtains the first filtrate and the first filtering residue；Add with second to first filtering residue and steam
Distilled water simultaneously carries out reflux, extract, 1-2h at 90-95 DEG C, centrifugation, filtration, obtains the second filtrate and the second filtering residue；By the described first filter
Liquid merges with the second filtrate, and concentration to be removed and carry out microporous filter after distilled water, obtains final product the radix sophorae extracting solution.
8. the plant extract of antiallergic antiinflammatory after-sun according to claim 7, it is characterised in that in step (C1),
The particle diameter of the radix sophorae fine powder is 35-45 mesh；
In step (C2), the radix sophorae fine powder is 1 with the mass ratio of addition distilled water for the first time:18-1:22；First filter
Slag is 1 with the mass ratio of second addition distilled water:18-1:22；
The concentration is water-bath concentration, and the temperature of the concentration is 85-95 DEG C, and the filter sizes for carrying out the microporous filter are
0.4-0.5μm。
9. the preparation method of the plant extract of the antiallergic antiinflammatory after-sun described in a kind of any one of claim 1-8, it is special
Levy and be, concretely comprise the following steps：
After taking the rice fermentation liquid, Herba Portulacae extract and radix sophorae extracting solution respectively and being mixed, ripple angle fork is added
Dish extract, is sufficiently mixed uniformly, obtains final product the plant extract.
10. application of the plant extract in the skin care item for preparing antiallergic antiinflammatory after-sun described in any one of claim 1-8.
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| CN107260595A (en) * | 2017-06-01 | 2017-10-20 | 南京辅安堂药业有限公司 | One Plant Extracts antiallergy cream and preparation method thereof |
| CN108186467A (en) * | 2018-03-13 | 2018-06-22 | 赵坚 | Water and preparation method thereof is repaired made of a kind of pure plant |
| CN108186468A (en) * | 2018-03-13 | 2018-06-22 | 赵坚 | A kind of reparation water for repairing sun-damaged skin and preparation method thereof |
| CN108283591A (en) * | 2018-03-13 | 2018-07-17 | 赵坚 | A kind of reparation water and preparation method thereof with skin repair function after shining |
| CN108283592A (en) * | 2018-03-13 | 2018-07-17 | 赵坚 | A kind of after-sun water and preparation method thereof containing plant extracts |
| CN108294988A (en) * | 2018-03-13 | 2018-07-20 | 赵坚 | After-sun water and preparation method thereof made of one Plant Extracts |
| CN109394618A (en) * | 2018-11-27 | 2019-03-01 | 东莞市润孚化妆品有限公司 | A kind of antiallergy reparation skin-care agent |
| CN111714439A (en) * | 2020-06-11 | 2020-09-29 | 上海本正生物工程有限公司 | Anti-wrinkle essence powder and preparation method thereof |
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| CN107260595A (en) * | 2017-06-01 | 2017-10-20 | 南京辅安堂药业有限公司 | One Plant Extracts antiallergy cream and preparation method thereof |
| CN108186467A (en) * | 2018-03-13 | 2018-06-22 | 赵坚 | Water and preparation method thereof is repaired made of a kind of pure plant |
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| CN108283591A (en) * | 2018-03-13 | 2018-07-17 | 赵坚 | A kind of reparation water and preparation method thereof with skin repair function after shining |
| CN108283592A (en) * | 2018-03-13 | 2018-07-17 | 赵坚 | A kind of after-sun water and preparation method thereof containing plant extracts |
| CN108294988A (en) * | 2018-03-13 | 2018-07-20 | 赵坚 | After-sun water and preparation method thereof made of one Plant Extracts |
| CN109394618A (en) * | 2018-11-27 | 2019-03-01 | 东莞市润孚化妆品有限公司 | A kind of antiallergy reparation skin-care agent |
| CN111714439A (en) * | 2020-06-11 | 2020-09-29 | 上海本正生物工程有限公司 | Anti-wrinkle essence powder and preparation method thereof |
| CN113520950A (en) * | 2021-08-11 | 2021-10-22 | 云南白药集团上海科技有限公司 | Purslane extract, skin external preparation containing purslane extract, and preparation method and application of purslane extract |
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