CN106616427A - Nutrition and health care food rich in vitamin B12 and preparation method thereof - Google Patents
Nutrition and health care food rich in vitamin B12 and preparation method thereof Download PDFInfo
- Publication number
- CN106616427A CN106616427A CN201611226408.6A CN201611226408A CN106616427A CN 106616427 A CN106616427 A CN 106616427A CN 201611226408 A CN201611226408 A CN 201611226408A CN 106616427 A CN106616427 A CN 106616427A
- Authority
- CN
- China
- Prior art keywords
- liver
- cobastab
- solution
- rich
- coenzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000036541 health Effects 0.000 title claims abstract description 17
- 235000013305 food Nutrition 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims description 11
- 235000016709 nutrition Nutrition 0.000 title abstract description 7
- 239000011715 vitamin B12 Substances 0.000 title abstract description 7
- 230000035764 nutrition Effects 0.000 title abstract description 6
- 229930003779 Vitamin B12 Natural products 0.000 title abstract 4
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 title abstract 4
- 235000019163 vitamin B12 Nutrition 0.000 title abstract 4
- 210000004185 liver Anatomy 0.000 claims abstract description 66
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 54
- 239000005515 coenzyme Substances 0.000 claims abstract description 41
- 241001465754 Metazoa Species 0.000 claims abstract description 37
- 239000007788 liquid Substances 0.000 claims abstract description 23
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 19
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 19
- 235000011090 malic acid Nutrition 0.000 claims abstract description 19
- 239000001630 malic acid Substances 0.000 claims abstract description 19
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 17
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 17
- 239000001509 sodium citrate Substances 0.000 claims abstract description 17
- 239000000811 xylitol Substances 0.000 claims abstract description 17
- 235000010447 xylitol Nutrition 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 17
- 229960002675 xylitol Drugs 0.000 claims abstract description 17
- 235000012054 meals Nutrition 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 13
- 239000003826 tablet Substances 0.000 claims abstract description 11
- 239000002775 capsule Substances 0.000 claims abstract description 10
- 239000008187 granular material Substances 0.000 claims abstract description 6
- 239000006188 syrup Substances 0.000 claims abstract description 4
- 235000020357 syrup Nutrition 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 106
- 239000000243 solution Substances 0.000 claims description 60
- 235000013402 health food Nutrition 0.000 claims description 35
- 238000003756 stirring Methods 0.000 claims description 29
- 239000011259 mixed solution Substances 0.000 claims description 22
- 238000001035 drying Methods 0.000 claims description 21
- 210000002808 connective tissue Anatomy 0.000 claims description 14
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 13
- 239000012467 final product Substances 0.000 claims description 9
- 235000015277 pork Nutrition 0.000 claims description 7
- 244000118681 Iresine herbstii Species 0.000 claims description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 6
- 241000272525 Anas platyrhynchos Species 0.000 claims description 5
- 241001494479 Pecora Species 0.000 claims description 5
- 235000021336 beef liver Nutrition 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000012752 auxiliary agent Substances 0.000 claims description 4
- 239000007853 buffer solution Substances 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000003801 milling Methods 0.000 claims description 3
- 240000004307 Citrus medica Species 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 239000002023 wood Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 abstract description 2
- 230000000996 additive effect Effects 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 15
- 239000000047 product Substances 0.000 description 14
- 235000015165 citric acid Nutrition 0.000 description 13
- 235000011083 sodium citrates Nutrition 0.000 description 13
- 206010013786 Dry skin Diseases 0.000 description 10
- 238000005507 spraying Methods 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 239000002245 particle Substances 0.000 description 8
- 239000000843 powder Substances 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 239000002417 nutraceutical Substances 0.000 description 5
- 235000021436 nutraceutical agent Nutrition 0.000 description 5
- 230000000050 nutritive effect Effects 0.000 description 5
- 239000011782 vitamin Substances 0.000 description 5
- 235000013343 vitamin Nutrition 0.000 description 5
- 229940088594 vitamin Drugs 0.000 description 5
- 229930003231 vitamin Natural products 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 235000020985 whole grains Nutrition 0.000 description 4
- 208000007502 anemia Diseases 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 239000003182 parenteral nutrition solution Substances 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- 102000040350 B family Human genes 0.000 description 2
- 108091072128 B family Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000005030 aluminium foil Substances 0.000 description 2
- -1 cobalt amine Chemical class 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- MSTNYGQPCMXVAQ-KIYNQFGBSA-N 5,6,7,8-tetrahydrofolic acid Chemical compound N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-KIYNQFGBSA-N 0.000 description 1
- 208000027219 Deficiency disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010016880 Folate deficiency Diseases 0.000 description 1
- 208000010188 Folic Acid Deficiency Diseases 0.000 description 1
- 235000002710 Ilex cornuta Nutrition 0.000 description 1
- 241001310146 Ilex cornuta Species 0.000 description 1
- 206010025476 Malabsorption Diseases 0.000 description 1
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000003464 asthenopia Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- ZGRKFKYTCMLCCF-UHFFFAOYSA-N cobalt;oxalonitrile Chemical compound [Co].N#CC#N ZGRKFKYTCMLCCF-UHFFFAOYSA-N 0.000 description 1
- 239000011789 cobamamide Substances 0.000 description 1
- 229960005452 cobamamide Drugs 0.000 description 1
- 235000006279 cobamamide Nutrition 0.000 description 1
- ZIHHMGTYZOSFRC-UWWAPWIJSA-M cobamamide Chemical compound C1(/[C@](C)(CCC(=O)NC[C@H](C)OP(O)(=O)OC2[C@H]([C@H](O[C@@H]2CO)N2C3=CC(C)=C(C)C=C3N=C2)O)[C@@H](CC(N)=O)[C@]2(N1[Co+]C[C@@H]1[C@H]([C@@H](O)[C@@H](O1)N1C3=NC=NC(N)=C3N=C1)O)[H])=C(C)\C([C@H](C/1(C)C)CCC(N)=O)=N\C\1=C/C([C@H]([C@@]\1(CC(N)=O)C)CCC(N)=O)=N/C/1=C(C)\C1=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O ZIHHMGTYZOSFRC-UWWAPWIJSA-M 0.000 description 1
- 239000000039 congener Substances 0.000 description 1
- 239000011666 cyanocobalamin Substances 0.000 description 1
- 229960002104 cyanocobalamin Drugs 0.000 description 1
- 235000000639 cyanocobalamin Nutrition 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000019688 fish Nutrition 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- ZNOVTXRBGFNYRX-ABLWVSNPSA-N levomefolic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-ABLWVSNPSA-N 0.000 description 1
- 235000007635 levomefolic acid Nutrition 0.000 description 1
- 239000011578 levomefolic acid Substances 0.000 description 1
- 229940040511 liver extract Drugs 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- ZIYVHBGGAOATLY-UHFFFAOYSA-N methylmalonic acid Chemical compound OC(=O)C(C)C(O)=O ZIYVHBGGAOATLY-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 210000005012 myelin Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000020939 nutritional additive Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000003408 sphingolipids Chemical class 0.000 description 1
- 229960005137 succinic acid Drugs 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Meat, Egg Or Seafood Products (AREA)
Abstract
The invention belongs to the technical field of health care food processing and relates to a nutrition and health care food rich in vitamin B12 and a method for preparing the health care food. Every 1000 g of nutrition and health care food rich in vitamin B12 is formed by 0.002-0.01 g of coenzyme vitamin B12, 45-65 g of sodium citrate, 31-43 g of citric acid, 1.8-2.2 g of malic acid, 50-100 g of xylitol, and the balance animal liver meal. The product can serve as an additive raw material of the nutrition and health care product to be used, auxiliaries capable of being accepted for food processing can be added as required to be processed into granules, tablets, capsules, oral liquids or syrup and the like, and more choices are provided for selection and application by users.
Description
Technical field
The invention belongs to health food manufacture field, and in particular to one kind is rich in Cobastab12Nutrient and healthcare products and the guarantor
The preparation method of strong product.
Background technology
Animal's liver is rich in vitamin A, its content considerably beyond food such as milk, egg, meat and fishes, with maintaining human normal
Growth and the effect of Reproductive Performance.Can protect eyes, maintain twenty-twenty vision, prevent that eyes are dry and astringent, fatigue.Contain in animal's liver
Vitamin e and trace elements of selenium that general meat product does not have, can strengthen the immune response of human body, anti-oxidant, anti-aging, and
The generation of tumour cell can be suppressed, the colour of skin of health is maintained.Animal's liver iron content is enriched, and appropriate fed animals liver can make skin
Ruddy, animal's liver is rich in protein, amino acid, particularly B family vitamins, Cobastab12Content is higher, with battalion well
Support and blood tonification effect, with aid digestion, orectic effect.The normal food animal livers of Jing can also replenishing vitamins B12, this benefit
The important coenzyme of body is filled, removal of the body to some toxic components is completed and be there is important function.Animal's liver Jing hydrolysis is made
Medicinal extract, nutritive value has large increase compared with tripe itself, and protein therein and aminoacid ingredient are by hydrolyzing to form amino acid
Or amino acid peptides, the more conducively absorption and utilization of human body.As clinical treatment medication, in 20th century 60-70 alternative pork liver
Made by liver extract tablet, tripe essence parenteral solution, liver B12Piece, liver B12Parenteral solution etc. as former red blood cell anaemia, hypoferric anemia,
The therapeutic agent of the disease such as pregnancy period and trophism E red blood cell anaemia, hepatitis, indigestion, malnutrition.
Today's society is accelerated due to the rhythm of life of people, and the popularization of computer internet, weakly personnel increase year by year
Plus, the particularly health hazard by brain worker visual fatigue to people is larger and common, there is provided one kind can supplement people battalion
The health type health food that supporting needs is also the needs of people plus fast pace life.For this purpose, applicant just grinds for animal's liver
The nourishment food sent out, have submitted two pieces patent application, one of which nutraceutical and production method（CN103719855A）With
A kind of health food（CN103734767A）For the effectively utilizes of animal's liver, expand the utilization of resources and abundant nutrition food kind
Achieve beneficial effect.The nutritive value and effect of animal's liver, can be with from the liver nutrition of animal and clinical practice
Find out, mainly how many vitamin contents surpasses critical effect, B family vitamins rise to effect that is aid digestion, increasing appetite
To effect well, V B12Content determine that the temperature during animal's liver working process, the hydrolysis under acid-base condition make
Obtain Cobastab12Destroyed, caused Cobastab12Component content it is little, as a result cause its application effect of products not good, because
And, medicine prepared by the LEx of clinical medicine application adds Cobastab mostly12Compound preparation is made, to ensure that it faces
Bed application effect.But due to Cobastab12Draw moist relatively strong, in high temperature or have oxidant, heavy metal salt and microorganism
Under the conditions of be allowed to fail, temperature is too high or processing disinfecting time is long can be allowed to decompose so that product can not rise well
To practical application, forced for vitamins B12And the Cobastab for making12Product there is good stability, be exploitation animal's liver
One of nutraceutical and health products effective way.
The content of the invention
It is an object of the invention to provide a kind of in good taste, without fishy smell, instant, the one kind being of high nutritive value is rich in dimension
Raw element B12Nutrient and healthcare products preparation method.
For achieving the above object, present invention employs technical scheme below：
One kind is rich in Cobastab12Nutritional health food, it is characterized in that being formed by the material combination of following weight proportioning, every
1000g is rich in Cobastab12Nutritional health food in coenzyme Cobastab120.002-0.01g, sodium citrate 45-65g, citron
Sour 31-43g, malic acid 1.8-2.2g, xylitol 50-100g, remaining is animal liver meal；Method is prepared as follows to be obtained：Take auxiliary
Enzyme Cobastab12Being dissolved in 65-68 DEG C of water makes into 100g solution for standby；Sodium citrate, citric acid, malic acid and xylitol are separately taken,
Add water respectively successively stirring and dissolving in 50 DEG C of water, makes 2000g solution, then takes animal liver meal and mixes with solution, is subsequently adding
State coenzyme Cobastab12Solution, and with citric acid-sodium citrate buffer solution pH value is adjusted to 4.3-4.6, and add 65-68 DEG C of heat
Water is mixed to 4.0kg, spray-dried, makes water content in 1%-3%, is obtained rich in Cobastab12Nutritional health food.
It is of the invention obtained rich in Cobastab12Nutritional health food can make as the additive raw material of nutrient and healthcare products
With.Food processing acceptable auxiliary agent (auxiliary material) can also be as needed added to be further processed into granule, tablet, capsule
The internal dosage forms such as agent.
Appropriate auxiliary agent and solvent can also be as needed added to be further processed into the Oral preparations such as oral liquid or syrup
Type.
The animal liver meal that the present invention is adopted is any one in chicken gizzard, duck liver, foie gras, rabbit liver, sheep liver, pork liver, beef liver
Fresh or quick-frozen liver is obtained by existing method, and its preparation method is：The fresh or quick-frozen animal's liver of health is taken, fat is removed
And connective tissue, it is milled after 80-100 DEG C of drying, 100 mesh sieves are crossed, obtain animal liver meal.
In order to be dried convenient and ensure drying effect, animal's liver can be cut into before being dried to liver suitable little
It is block.
Cobastab12Also known as cyanocobalamin, it is important coenzyme that cell makes into nucleotides, participate in internal methyl conversion and folic acid
Metabolism, promotes 5-methyltetrahydrofolate ink marks to be tetrahydrofolic acid.During shortage, folic acid deficiency can be caused, and therefore cause DNA to make into barrier
Hinder, affect development and the maturation of red blood cell.Cobastab12Also promote methylmalonic acid to be changed into butanedioic acid, participate in tricarboxylic circulation.
This interactively to sphingolipids make into and vitamin has sheath nerve fibre fully functional, Cobastab12The god of deficiency disease
Jing infringements may be relevant with this.Cobastab12It is main to be provided by food but when human body lacks, it is often necessary to give enough dimensions
Raw element B12To reach the purpose for the treatment of disease, in order to play nutraceutical obtained in animal's liver human body needs are met
Cobastab12, using the method for reinforcing addition, the beneficial functional of liver nutraceutical can be effectively improved.Due to Cobastab12Tool
There is unstability, often result in the Cobastab in food12Loss or failure and the factor such as malabsorption, be extremely difficult to good
Application effect, therefore clinical medicine is often with Cobastab12Parenteral solution Jing intramuscular injection gives application.However, coenzyme Cobastab12, also known as
Coenzyme Cobastab12, cobamamide, be cyanogen cobalt type Cobastab12Congener, i.e., its CN base by gland it is fast cry of certain animals nucleic acid replace, become
5 '-desoxyadenossine cobalt amine, it is internal Cobastab12One of two kinds of active coenzyme forms, be cell growth breeding and tie up life
The complete necessary material of plain nervous system myelin.Due to coenzyme Cobastab12Suitable for oral delivery simultaneously can be absorbed directly,
It is active strong, regard with histocyte and power be strong, excretion relatively slowly, as nutritional health food application than Cobastab12With more preferable
Stable and application effect.
The technical solution adopted for the present invention to solve the technical problems can also be further perfect.By following weight proportioning
Feedstock optimization combination is made:Cobastab is rich in every 1000g12Nutritional health food in coenzyme Cobastab120.006g, Chinese holly
Rafter acid sodium 55.0g, citric acid 37.0g, malic acid 2.0g, xylitol 75.0g, remaining is animal liver meal.
One kind is rich in Cobastab12Nutritional health food preparation method, it is characterised in that comprise the steps：（1）Claim
Take formula ratio coenzyme dimension B12In being dissolved in 65-68 DEG C of appropriate amount of purified water, stirring makes molten, 65-68 DEG C of enough appropriate amount of purified water of addition,
It is dissolved to 100g solution for standby；（2）Formula ratio sodium citrate, citric acid, malic acid and xylitol are weighed respectively, sequentially add 50
In DEG C pure water, stirring and dissolving makes 2000g solution；（3）Weigh animal liver meal elder generation and the step of formula ratio（2）It is obtained molten
Liquid mixes, and then adds step（1）Obtained coenzyme ties up B12Solution mixes, and stirs, and obtains mixed solution；（4）Will mixing
Solution adjusts PH4.3-4.6 using citric acid-sodium citrate buffer solution, and adds 65-68 DEG C of pure water to 4.0kg, mixes,
It is spray-dried, make water content in 1%-3%, obtain rich in Cobastab12Nutritional health food；Wherein animal liver meal is chicken gizzard, duck
Any one fresh or quick-frozen liver in liver, foie gras, rabbit liver, sheep liver, pork liver, beef liver is obtained by the following method：Take healthy new
Fresh or quick-frozen animal's liver, removes fat and connective tissue, and after cleaning up, after 80-100 DEG C of drying, milling crosses 100
Mesh sieve, obtains final product.
Beneficial effects of the present invention
The present invention provide rich in Cobastab12Nutritional health food, be that B is tieed up by coenzyme12Combine with hepar siccatum and make, except having
The nutritive value that animal's liver possesses also fully is enriched Cobastab12Content so as to benefiting action is more useful carried
It is high.Due to animal's liver work in-process Cobastab12Loss and failure, often do not reach its help effect, add vitamin
B12To lifting Cobastab12The meaning for ensureing its nutritive value containing measurer.The coenzyme dimension B of present invention addition12With suitable mouth
Clothes, can directly reclaim wasteland recommendation forehead, and activity is strong, regard with histocyte and power is strong, the characteristics of drain slower, preparation work of the invention
Artistic skill further increases coenzyme dimension B12Stability so that manufactured goods have the guarantee of stability and effect.Preparation side of the invention
Method process is simple, it is easy to manipulate, low cost, it is easy to industrialization production.The inventive method is the effectively utilizes of animal's liver, is battalion
Foster food adds new varieties.Serve the beneficial effect for expanding the utilization of resources.
Obtained product of the invention can be used as the nutritive additive of nutraceutical or health food.
It is of the invention obtained rich in Cobastab12Nutritional health food can also as needed add food processing to connect
The auxiliary agent received is further processed into the internal dosage forms such as granule, tablet, capsule, oral liquid and syrup.
Specific embodiment
Whole following examples of the present invention are only to regard further illustrating of making to the present invention as, and non-invention is complete
Portion.
Embodiment 1
The fresh chicken gizzard of health is taken, fat and connective tissue is removed, with pure water rinsed clean repeatedly, is drained away the water, cut with knife
Into fritter, it is placed in electric drier after 80 DEG C of dryings, grinds cross 100 mesh sieves, obtain dry mesh powder standby.
Embodiment 2
The quick-frozen chicken gizzard of health is taken, in being placed in cold pure water, is allowed after its naturally to thaw, remove fatty brain and connective tissue, then used
Pure water rinse is totally pulled out, is drained away the water, and is cut into fritter by knife, is placed in electric drier, after 90 DEG C of dryings, is worn into
Powder, crosses 100 mesh sieves, hepar siccatum is obtained standby.
Embodiment 3
The fresh duck liver of health is taken, fat and connective tissue is removed, with pure water rinsed clean repeatedly, is pulled out, drained away the water, used
Knife is cut into small pieces, and is placed in electric drier, and after 85 DEG C of dryings, grinds cross 100 mesh sieves, hepar siccatum are obtained standby.
Embodiment 4
The quick-frozen foie gras of healthy Jing is taken, in being placed in cold pure water, is allowed after its naturally to thaw, remove fat and connective tissue, then used
Pure water rinse is clean, pulls out, drains away the water, and is cut into fritter by knife, is placed in electric drier, after 95 DEG C of dryings, wears into
Powder, crosses 100 mesh sieves, hepar siccatum is obtained standby.
Embodiment 5
The fresh rabbit liver of health is taken, fat and connective tissue is removed, with pure water rinsed clean repeatedly, is pulled out, drained away the water, used
Knife is cut into small pieces, and is placed in electric drier, and after 95 DEG C of dryings, grinds cross 100 mesh sieves, hepar siccatum are obtained standby.
Embodiment 6
The quick-frozen rabbit livers of healthy Jing are taken, cold pure water is placed in, is allowed after its naturally to thaw, remove fat and connective tissue, then with pure
Water-removing rinsing is clean, pulls out, drains away the water, and is cut into fritter by knife, is placed in electrically heated drying cabinet, size-reduced after 98 DEG C of dryings
100 mesh sieves are crossed, hepar siccatum is obtained standby.
Embodiment 7
Take the quick-frozen sheep livers of healthy Jing, in being placed in cold pure water, allow its it is naturally quiet it is cold after, remove fat and connective tissue, then use
Pure water rinse is clean, pulls out, drains away the water, and is cut into fritter by knife, is placed in electrically heated drying cabinet, after 100 DEG C of dryings, Jing powder
It is broken, 100 mesh sieves are crossed, hepar siccatum is obtained standby.
Embodiment 8
The fresh pork liver of health is taken, fat and connective tissue is removed, with pure water rinsed clean repeatedly, is pulled out, drained away the water, used
Knife is cut into small pieces, and is placed in electric drier, size-reduced after 100 DEG C of dryings, crosses 100 mesh sieves, hepar siccatum is obtained standby.
Embodiment 9
Take the quick-frozen pork livers of healthy Jing, in being placed in cold pure water, allow its it is naturally quiet it is cold after, remove fat and connective tissue, then use
Pure water rinse is clean, pulls out, drains away the water, and is cut into fritter by knife, is placed in electrically heated drying cabinet, after 95 DEG C of dryings, Jing powder
It is broken, 100 mesh sieves are crossed, hepar siccatum is obtained standby.
Embodiment 10
Take the quick-frozen beef livers of healthy Jing, in being placed in cold pure water, allow its it is naturally quiet it is cold after, remove fat and connective tissue, then use
Pure water rinse is clean, pulls out, drains away the water, and is cut into fritter by knife, is placed in electrically heated drying cabinet, after 100 DEG C of dryings, Jing powder
It is broken, 100 mesh sieves are crossed, hepar siccatum is obtained standby.
Embodiment 11
（1）Weigh coenzyme dimension B120.006g, in being dissolved in the pure water of 68 DEG C of 80g, after being stirred to dissolve, then adds 68 DEG C
Pure water is settled to 100g solution；（2）Sodium citrate 55.0g, citric acid 37.0g, malic acid 2.0g and xylitol are weighed respectively
75.0g, is added sequentially to 50 DEG C in 1000g pure water, stirring, dissolving, and 50 DEG C of pure water are then added again, and to make 2000g molten
Liquid；（3）Weigh hepar siccatum 830.994g and step obtained in embodiment 1（2）Obtained solution mixing, then adds step（1）
Obtained coenzyme ties up B12Solution mixes, and stirs, and obtains mixed solution；（4）Mixed solution is adopted into citric acid-sodium citrate
Cushioning liquid adjusts pH value to 4.6, and 68 DEG C of pure water are then added again makes solution to 4.0kg, is uniformly mixed, and Jing sprayings are dry
It is dry, make water content in 1%-3%, obtain rich in Cobastab12Nutritional health food.
Embodiment 12
（1）Weigh coenzyme dimension B120.002g, in being dissolved in the pure water of 65 DEG C of 80g, after being stirred to dissolve, then adds 65 DEG C
Pure water is settled to 100g solution；（2）Sodium citrate 45g, citric acid 31g, malic acid 1.8g and xylitol 50g are weighed respectively,
65 DEG C are added sequentially to in 1000g pure water, then stirring, dissolving adds again 50 DEG C of pure water and make 2000g solution；（3）
Weigh hepar siccatum 872.198g and step obtained in embodiment 2（2）Obtained solution mixing, then adds step（1）It is obtained
Coenzyme ties up B12Solution mixes, and stirs, and obtains mixed solution；（4）Mixed solution is molten using citric acid-sodium citrate buffering
Liquid adjusts pH value to 4.3, and 65 DEG C of pure water are then added again makes solution to 4.0kg, is uniformly mixed, spray-dried, makes
Water content is obtained rich in Cobastab in 1%-3%12Nutritional health food.
Embodiment 13
（1）Weigh coenzyme dimension B120.005g, in being dissolved in the pure water of 66 DEG C of 80g, after being stirred to dissolve, then adds 66 DEG C
Pure water is settled to 100g solution；（2）Sodium citrate 65.0g, citric acid 43.0g, malic acid 2.2g and xylitol are weighed respectively
100g, is added sequentially to 66 DEG C in 1000g pure water, stirring, dissolving, and 50 DEG C of pure water are then added again, and to make 2000g molten
Liquid；（3）Weigh hepar siccatum 889.795g and step obtained in embodiment 3（2）Obtained solution mixing, then adds step（1）
Obtained coenzyme ties up B12Solution mixes, and stirs, and obtains mixed solution；（4）Mixed solution is adopted into citric acid-sodium citrate
Cushioning liquid adjusts pH value to 4.4, and 66 DEG C of pure water are then added again makes solution to 4.0kg, is uniformly mixed, and Jing sprayings are dry
It is dry, make water content in 1%-3%, obtain rich in Cobastab12Nutritional health food.
Embodiment 14
（1）Weigh coenzyme dimension B120.0035g, in being dissolved in the pure water of 65 DEG C of 80g, after being stirred to dissolve, then adds 65 DEG C
Pure water is settled to 100g solution；（2）Sodium citrate 50.0g, citric acid 40.0g, malic acid 2.1g and xylitol are weighed respectively
100g, is added sequentially to 50 DEG C in 1000g pure water, stirring, dissolving, and 50 DEG C of pure water are then added again, and to make 2000g molten
Liquid；（3）Weigh hepar siccatum 847.8965g and step obtained in embodiment 4（2）Obtained solution mixing, then adds step（1）
Obtained coenzyme ties up B12Solution mixes, and stirs, and obtains mixed solution；（4）Mixed solution is adopted into citric acid-sodium citrate
Cushioning liquid adjusts pH value to 4.5, and 65 DEG C of pure water are then added again makes solution to 4.0kg, is uniformly mixed, and Jing sprayings are dry
It is dry, make water content in 1%-3%, obtain rich in Cobastab12Nutritional health food.
Embodiment 15
（1）Weigh coenzyme dimension B120.006g, in being dissolved in the pure water of 65 DEG C of 80g, after being stirred to dissolve, then adds 65 DEG C
Pure water is settled to 100g solution；（2）Sodium citrate 55.0g, citric acid 37.0g, malic acid 2.0g and xylitol are weighed respectively
75.0g, is added sequentially to 50 DEG C in 1000g pure water, stirring, dissolving, and 50 DEG C of pure water are then added again, and to make 2000g molten
Liquid；（3）Weigh hepar siccatum 830.994g and step obtained in embodiment 5（2）Obtained solution mixing, then adds step（1）
Obtained coenzyme ties up B12Solution mixes, and stirs, and obtains mixed solution；（4）Mixed solution is adopted into citric acid-sodium citrate
Cushioning liquid adjusts pH value to 4.6, and 68 DEG C of pure water are then added again makes solution to 4.0kg, is uniformly mixed, and Jing sprayings are dry
It is dry, make water content in 1%-3%, obtain rich in Cobastab12Nutritional health food.
Embodiment 16
（1）Weigh coenzyme dimension B120.01g, in being dissolved in the pure water of 68 DEG C of 80g, after being stirred to dissolve, then adds 68 DEG C pure
Water purification is settled to 100g solution；（2）Sodium citrate 65.0g, citric acid 43.0g, malic acid 2.2g and xylitol are weighed respectively
100g, is added sequentially to 50 DEG C in 1000g pure water, stirring, dissolving, and 50 DEG C of pure water are then added again, and to make 2000g molten
Liquid；（3）Weigh hepar siccatum 789.79g and step obtained in embodiment 6（2）Obtained solution mixing, then adds step（1）System
The coenzyme dimension B for obtaining12Solution mixes, and stirs, and obtains mixed solution；（4）Mixed solution is slow using citric acid-sodium citrate
Rush solution and adjust pH value to 4.5,68 DEG C of pure water are then added again makes solution to 4.0kg, is uniformly mixed, Jing sprayings are dry
It is dry, make water content in 1%-3%, obtain rich in Cobastab12Nutritional health food.
Embodiment 17
（1）Weigh coenzyme dimension B120.004g, in being dissolved in the pure water of 67 DEG C of 80g, after being stirred to dissolve, then adds 67 DEG C
Pure water is settled to 100g solution；（2）Sodium citrate 48.0g, citric acid 34.0g, malic acid 2.1g and xylitol are weighed respectively
80g, is added sequentially to 50 DEG C in 1000g pure water, stirring, dissolving, and 50 DEG C of pure water are then added again, and to make 2000g molten
Liquid；（3）Weigh hepar siccatum 835.896g and step obtained in embodiment 7（2）Obtained solution mixing, then adds step（1）
Obtained coenzyme ties up B12Solution mixes, and stirs, and obtains mixed solution；（4）Mixed solution is adopted into citric acid-sodium citrate
Cushioning liquid adjusts pH value to 4.4, and 67 DEG C of pure water are then added again makes solution to 4.0kg, is uniformly mixed, and Jing sprayings are dry
It is dry, make water content in 1%-3%, obtain rich in Cobastab12Nutritional health food.
Embodiment 18
（1）Weigh coenzyme dimension B120.007g, in being dissolved in the pure water of 68 DEG C of 80g, after being stirred to dissolve, then adds 68 DEG C
Pure water is settled to 100g solution；（2）Sodium citrate 60.0g, citric acid 41.0g, malic acid 2.0g and xylitol are weighed respectively
85g, is added sequentially to 50 DEG C in 1000g pure water, stirring, dissolving, and 50 DEG C of pure water are then added again, and to make 2000g molten
Liquid；（3）Weigh hepar siccatum 811.993g and step obtained in embodiment 8（2）Obtained solution mixing, then adds step（1）
Obtained coenzyme ties up B12Solution mixes, and stirs, and obtains mixed solution；（4）Mixed solution is adopted into citric acid-sodium citrate
Cushioning liquid adjusts pH value to 4.3, and 68 DEG C of pure water are then added again makes solution to 4.0kg, is uniformly mixed, and Jing sprayings are dry
It is dry, make water content in 1%-3%, obtain rich in Cobastab12Nutritional health food.
Embodiment 19
（1）Weigh coenzyme dimension B120.006g, in being dissolved in the pure water of 66 DEG C of 80g, after being stirred to dissolve, then adds 66 DEG C
Pure water is settled to 100g solution；（2）Sodium citrate 55.0g, citric acid 37.0g, malic acid 2.0g and xylitol are weighed respectively
75.0g, is added sequentially to 50 DEG C in 1000g pure water, stirring, dissolving, and 50 DEG C of pure water are then added again, and to make 2000g molten
Liquid；（3）Weigh hepar siccatum 830.994g and step obtained in embodiment 9（2）Obtained solution mixing, then adds step（1）
Obtained coenzyme ties up B12Solution mixes, and stirs, and obtains mixed solution；（4）Mixed solution is adopted into citric acid-sodium citrate
Cushioning liquid adjusts pH value 4.65, and 66 DEG C of pure water are then added again makes solution to 4.0kg, is uniformly mixed, and Jing sprayings are dry
It is dry, make water content in 1%-3%, obtain rich in Cobastab12Nutritional health food.
Embodiment 20
（1）Weigh coenzyme dimension B120.008g, in being dissolved in the pure water of 68 DEG C of 80g, after being stirred to dissolve, then adds 68 DEG C
Pure water is settled to 100g solution；（2）Sodium citrate 63.0g, citric acid 42.0g, malic acid 2.1g and xylitol are weighed respectively
85.0g, is added sequentially to 50 DEG C in 1000g pure water, stirring, dissolving, and 50 DEG C of pure water are then added again, and to make 2000g molten
Liquid；（3）Weigh hepar siccatum 807.89g and step obtained in embodiment 10（2）Obtained solution mixing, then adds step（1）
Obtained coenzyme ties up B12Solution mixes, and stirs, and obtains mixed solution；（4）Mixed solution is adopted into citric acid-sodium citrate
Cushioning liquid adjusts pH value 4.6, and 68 DEG C of pure water are then added again makes solution to 4.0kg, is uniformly mixed, and Jing sprayings are dry
It is dry, make water content in 1%-3%, obtain rich in Cobastab12Nutritional health food.
Embodiment 21
Weigh that embodiment 11 obtains rich in Cobastab12Nutritional health food 10kg, with Jiangsu flora drying equipment factory give birth to
The GK-80 types dry type of product is thrown grain machine and is directly compressed into 18 mesh particles, using Polythene Bag quantitative vacuum packaging, obtains final product granule
Type.
Embodiment 22
By particle obtained in embodiment 21, after whole grain, the 1.0 grams of filling capsules every time in capsule filling machine, Ran Houyong
Aluminium foil bag nitrogen-filled packaging, obtains final product capsule finished product.
Embodiment 23
By particle obtained in embodiment 21, Jing after whole grain, 250 grams of magnesium stearate is added fully to mix with particle, using tablet press machine
Tabletted heavy 1.0 grams of tablet, then using vacuum or nitrogen-filled packaging, obtains final product tablet finished product.
Embodiment 24
Weigh that embodiment 15 obtains rich in Cobastab12Nutritional health food 10kg, being placed in the step drying equipment of Jiangsu one has
In the GHL type high-speed mixing granulating machines of limit company production, wetting agent is made for 65% ethanol with content, soft material is made in stirring, will be soft
Timber-used JZL type Squeezinggranulator makes 16 mesh particles, then inserts in baking oven, dries to water content under the conditions of 65-70 DEG C and exists
1%-2%, is vacuum-packed using polyethylene bag, obtains final product granule in blocks.
Embodiment 25
By particle obtained in embodiment 24, after whole grain, with 0.5 gram every time filling capsule in capsule filling machine, then adopt
Aluminium foil bag nitrogen-filled packaging is used, capsule finished product is obtained final product.
Embodiment 26
By particle obtained in embodiment 24, Jing after whole grain, 200 grams of magnesium stearate is added fully to mix with particle, using tablet press machine
Tabletted heavy 0.5 gram of tablet, then using vacuum or nitrogen-filled packaging, obtains final product tablet finished product.
Claims (4)
1. it is a kind of to be rich in Cobastab12Nutritional health food, it is characterized in that being formed by the material combination of following weight proportioning,
Cobastab is rich in per 1000g12Nutritional health food in, coenzyme Cobastab120.002-0.01g, sodium citrate 45-65g,
Citric acid 31-43g, malic acid 1.8-2.2g, xylitol 50-100g, remaining is animal liver meal；Method is prepared as follows to be obtained：
Take coenzyme Cobastab12Being dissolved in 65-68 DEG C of water makes into 100g solution for standby；Separately take sodium citrate, citric acid, malic acid and wood
Sugar alcohol, stirring and dissolving in the 50 DEG C of water that add water respectively successively makes 2000g solution, then takes animal liver meal and mixes with solution, then
Add above-mentioned coenzyme Cobastab12Solution, and with citric acid-sodium citrate buffer solution pH value is adjusted to 4.3-4.6, and add 65-
68 DEG C of hot water are mixed to 4.0kg, spray-dried, make water content in 1%-3%, are obtained rich in Cobastab12Nutritional health food；
Described animal liver meal be chicken gizzard, duck liver, foie gras, rabbit liver, sheep liver, pork liver, beef liver in any one fresh or quick-frozen liver press with
Lower section method is obtained：The fresh or quick-frozen animal's liver of health is taken, fat and connective tissue is removed, after cleaning up, is cut into little
Block, after 80-100 DEG C of drying, milling crosses 100 mesh sieves, obtains final product.
2. according to claim 1 rich in Cobastab12Nutritional health food, food processing can be added to receive
Auxiliary agent be further processed into granule, tablet, capsule, oral liquid or syrup.
3. according to claim 1 rich in Cobastab12Nutritional health food, it is characterised in that：By following weight proportion
Material combination make：Cobastab is rich in every 1000g12Nutritional health food in, coenzyme Cobastab120.006g, citron
Sour sodium 55.0g, citric acid 37.0g, malic acid 2.0g, xylitol 75.0g, remaining is animal liver meal.
4. it is a kind of to be rich in Cobastab as claimed in claim 112Nutritional health food preparation method, it is characterised in that include
Following steps：（1）Weigh formula ratio coenzyme dimension B12In being dissolved in 65-68 DEG C of appropriate amount of purified water, stirring makes molten, the enough 65- of addition
68 DEG C of appropriate amount of purified water, are dissolved to 100g solution for standby；（2）Formula ratio sodium citrate, citric acid, malic acid and wood are weighed respectively
Sugar alcohol, in sequentially adding 50 DEG C of pure water, stirring and dissolving makes 2000g solution；（3）Weigh the animal liver meal of formula ratio first with
Step（2）Obtained solution mixing, then adds step（1）Obtained coenzyme ties up B12Solution mixes, and stirs, and must mix
Solution；（4）Mixed solution is adjusted into PH4.3-4.6 using citric acid-sodium citrate buffer solution, and adds 65-68 DEG C of pure water
To 4.0kg, mix, it is spray-dried, make water content in 1%-3%, obtain rich in Cobastab12Nutritional health food；Wherein animal
Hepar siccatum be any one fresh or quick-frozen liver in chicken gizzard, duck liver, foie gras, rabbit liver, sheep liver, pork liver, beef liver by the following method
It is obtained：The fresh or quick-frozen animal's liver of health is taken, fat and connective tissue is removed, after cleaning up, fritter is cut into, in
After 80-100 DEG C of drying, milling crosses 100 mesh sieves, obtains final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611226408.6A CN106616427A (en) | 2016-12-27 | 2016-12-27 | Nutrition and health care food rich in vitamin B12 and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611226408.6A CN106616427A (en) | 2016-12-27 | 2016-12-27 | Nutrition and health care food rich in vitamin B12 and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106616427A true CN106616427A (en) | 2017-05-10 |
Family
ID=58832681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611226408.6A Withdrawn CN106616427A (en) | 2016-12-27 | 2016-12-27 | Nutrition and health care food rich in vitamin B12 and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106616427A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011409A (en) * | 2007-02-06 | 2007-08-08 | 浙江爱生药业有限公司 | Collunarium containing vitamin B12 |
| CN101194725A (en) * | 2008-01-09 | 2008-06-11 | 北京市科威华食品工程技术有限公司 | Sargassum fusiforme nutrition health care beverage |
| CN103689626A (en) * | 2013-12-30 | 2014-04-02 | 徐州绿之野生物食品有限公司 | Nutritious food and processing method thereof |
| CN105380124A (en) * | 2015-11-12 | 2016-03-09 | 北京五谷丰源食品有限公司 | Production method of animal liver powder containing selenium active substances |
| CN106107300A (en) * | 2016-07-30 | 2016-11-16 | 铜仁市万山区龙门山泉饮用水有限公司 | A kind of drinking water rich in vitamin |
-
2016
- 2016-12-27 CN CN201611226408.6A patent/CN106616427A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011409A (en) * | 2007-02-06 | 2007-08-08 | 浙江爱生药业有限公司 | Collunarium containing vitamin B12 |
| CN101194725A (en) * | 2008-01-09 | 2008-06-11 | 北京市科威华食品工程技术有限公司 | Sargassum fusiforme nutrition health care beverage |
| CN103689626A (en) * | 2013-12-30 | 2014-04-02 | 徐州绿之野生物食品有限公司 | Nutritious food and processing method thereof |
| CN105380124A (en) * | 2015-11-12 | 2016-03-09 | 北京五谷丰源食品有限公司 | Production method of animal liver powder containing selenium active substances |
| CN106107300A (en) * | 2016-07-30 | 2016-11-16 | 铜仁市万山区龙门山泉饮用水有限公司 | A kind of drinking water rich in vitamin |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2000049889A1 (en) | Animal feed supplement for the nutritional enrichment of animal produce | |
| CN104381586A (en) | Soybean peptide protein powder with scientific and reasonable proportion and preparation method of soybean peptide protein powder | |
| CN107927754A (en) | Tailored version clinical nutrition formula and preparation method thereof is energized during one kind production | |
| CN102422942A (en) | Radix Puerariae tea and preparation method thereof | |
| CN105707502A (en) | High-quality laying duck feed and preparation method thereof | |
| CN106578082A (en) | Milk powder containing peony seed oil and preparation method thereof | |
| CN109170916A (en) | One kind keeps fit and healthy food compositions and preparation method thereof | |
| CN103404598B (en) | Fish cheese and preparation method therof | |
| CN106616427A (en) | Nutrition and health care food rich in vitamin B12 and preparation method thereof | |
| CN110074274A (en) | A kind of growth pannage and preparation method thereof | |
| KR20170142077A (en) | method for manufacturing the diet feed for one's pet | |
| CN105341475A (en) | Meat duck feed additive raising immunity and preparation method therefor | |
| CN104642795A (en) | Meat rabbit feed additive | |
| CN109170154A (en) | The preparation method of the deer health-care feed of strengthen immunity | |
| CN103622090A (en) | Novel paste capable of strengthening kidney and enhancing physical strength | |
| CN109043222A (en) | A kind of raw fish expanded pellet diet preparation method | |
| CN107494746A (en) | A kind of functional food for promoting skeleton development and preparation method thereof | |
| RU2156594C1 (en) | Medicinal-prophylactic and baby dietary food product | |
| CN107751604A (en) | A kind of low-temperature water-soluble piglet opened guideway and its manufacture craft | |
| CN106721205A (en) | A kind of feed for improving goat meat | |
| CN107136490A (en) | A kind of peptide Chinese caterpillar fungus health product | |
| CN109845826B (en) | Baby milk powder simulating breast milk fatty acid structure and composition | |
| CN107789444A (en) | A kind of bright hair vitamine soft capsule prescription of pet dog and preparation method thereof | |
| JP2004049102A (en) | Health food and method for producing the same | |
| CN104664141A (en) | Preparation method of meat rabbit feed additive |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170510 |
|
| WW01 | Invention patent application withdrawn after publication |