CN106615538A - Gastrodia elata buccal tablets and preparation method thereof - Google Patents
Gastrodia elata buccal tablets and preparation method thereof Download PDFInfo
- Publication number
- CN106615538A CN106615538A CN201610910261.6A CN201610910261A CN106615538A CN 106615538 A CN106615538 A CN 106615538A CN 201610910261 A CN201610910261 A CN 201610910261A CN 106615538 A CN106615538 A CN 106615538A
- Authority
- CN
- China
- Prior art keywords
- parts
- gastrodia elata
- glauca
- essence
- buccal tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006189 buccal tablet Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 241000305491 Gastrodia elata Species 0.000 title abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 24
- 235000012907 honey Nutrition 0.000 claims abstract description 21
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 20
- 239000004375 Dextrin Substances 0.000 claims abstract description 13
- 229920001353 Dextrin Polymers 0.000 claims abstract description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 13
- 235000019425 dextrin Nutrition 0.000 claims abstract description 13
- 239000008103 glucose Substances 0.000 claims abstract description 13
- 229920002261 Corn starch Polymers 0.000 claims abstract description 12
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 12
- 239000008120 corn starch Substances 0.000 claims abstract description 12
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 11
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 9
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 9
- 241000837768 Gastrodia elata f. glauca Species 0.000 claims description 55
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- 229940046011 buccal tablet Drugs 0.000 claims description 26
- 238000001035 drying Methods 0.000 claims description 17
- 239000011122 softwood Substances 0.000 claims description 16
- 239000011812 mixed powder Substances 0.000 claims description 12
- 229940099112 cornstarch Drugs 0.000 claims description 11
- 235000011449 Rosa Nutrition 0.000 claims description 8
- 244000246386 Mentha pulegium Species 0.000 claims description 6
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 6
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 6
- 239000005864 Sulphur Substances 0.000 claims description 6
- 240000000851 Vaccinium corymbosum Species 0.000 claims description 6
- 235000003095 Vaccinium corymbosum Nutrition 0.000 claims description 6
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims description 6
- 235000021014 blueberries Nutrition 0.000 claims description 6
- 235000013339 cereals Nutrition 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 6
- 235000001050 hortel pimenta Nutrition 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- 239000000341 volatile oil Substances 0.000 claims description 6
- 235000020985 whole grains Nutrition 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- 235000001727 glucose Nutrition 0.000 claims description 3
- 235000011837 pasties Nutrition 0.000 claims description 3
- 239000008188 pellet Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 6
- 238000005516 engineering process Methods 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 235000019441 ethanol Nutrition 0.000 description 13
- 230000000694 effects Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 235000001465 calcium Nutrition 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 210000000697 sensory organ Anatomy 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- DKXULEFCEORBJK-UHFFFAOYSA-N magnesium;octadecanoic acid Chemical compound [Mg].CCCCCCCCCCCCCCCCCC(O)=O DKXULEFCEORBJK-UHFFFAOYSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229940023488 pill Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000013441 quality evaluation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Alternative & Traditional Medicine (AREA)
- Nutrition Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Physiology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses gastrodia elata buccal tablets. The gastrodia elata buccal tablets comprise the following components in parts by mass: 30-50 parts of gastrodia elata powder, 20-40 parts of corn starch, 5-10 parts of dextrin, 10-20 parts of glucose, 5-8 parts of honey, 0.5-1 part of sodium carboxymethyl cellulose, 0-0.3 part of magnesium stearate and 0-0.1 part of essence. The invention further discloses a preparation method of the gastrodia elata buccal tablets. Through the adoption of a production technology of the buccal tablets, compared with a conventional eating manner, the buccal tablets have the characteristics that the buccal tablets are more convenient to eat, and effective components are not liable to run off. Compared with conventional health-care products and drug preparations, the gastrodia elata buccal tablets have the advantages of being good in mouth feel when being eaten, good in absorption, convenient to eat and the like.
Description
Technical field
The invention belongs to health food manufacture field, specifically, is related to a kind of gastrodia elata f. glauca buccal tablet and preparation method thereof.
Background technology
Rhizoma Gastrodiae (Gastrodia elata) for orchid rhizoma Gastrodiae dry tuber, the effect of stop convulsion with suppressing hyperactive liver for calming endogenous wind.
The history that rhizoma Gastrodiae is used as medicine existing more than 2,000 years, the successive dynasties are on the books and are classified as top grade,《Sheng Nong's herbal classic》Cloud：Long term usage
Beneficial gas power, long cloudy fertilizer is strong.Li Shizhen (1518-1593 A.D.) is said：Help is added medicine to, and rhizoma Gastrodiae is first, and common people only control wind with it, good unfortunate.
Modern pharmacological research also indicates that rhizoma Gastrodiae is not only the god's medicine for controlling wind, also to senile dementia, hypertension, calm peace
God, promote sleep, improve the aspects such as memory and be respectively provided with different degrees of curative effect.
Gastrodia elata f. glauca is also referred to as iron rhizoma Gastrodiae, black stalk rhizoma Gastrodiae, main product in Yunnan Province of China northeast (i.e. modern Zhaotong City), Guizhou, four
The ground such as river are also distributed, and the most suitable growth is at more than height above sea level 1500m, air humidity more than 80%, 13.0 DEG C of year-round average temperature
High and cold mountain area, is the top grade in rhizoma Gastrodiae.
At present, food custom of the consumers in general using rhizoma Gastrodiae as daily health caring still buys whole rhizoma Gastrodiae by market
Based on dry tuber, dry gastrodia elata slice, Rhizoma Gastrodiae powder, also there is part to buy in the season of fresh rhizoma Gastrodiae listing；It is many with stewed in edible way
The extensive traditional form such as boil, be soaked in honey, steep in wine.The main formulation of health food, medicine with rhizoma Gastrodiae as raw material as pill,
Oral tablet, capsule, powder.But for example mouthfeel is poor for all more or less presence, absorb slow, edible troublesome, active component loss
The problems such as.
The content of the invention
In view of this, the present invention is directed to above-mentioned problem, there is provided a kind of gastrodia elata f. glauca buccal tablet and preparation method thereof.
In order to solve above-mentioned technical problem, the invention discloses a kind of gastrodia elata f. glauca buccal tablet, includes following according to mass parts
Component：Gastrodia elata f. glauca powder 30-50 parts, cornstarch 20-40 parts, dextrin 5-10 parts, glucose 10-20 parts, honey 5-8 parts, carboxylic first
Base sodium cellulosate 0.5-1 parts, magnesium stearate 0-0.3 parts, essence 0-0.1 parts.
Further, essence selects the one kind in Rosa Damascana, blueberry flavor, Peppermint essential oil.
The present invention also provides a kind of preparation method of gastrodia elata f. glauca buccal tablet, comprises the following steps：
1) gastrodia elata f. glauca powder is prepared：It is raw material to select a big, plump full, yellowish-white bright, gastrodia elata f. glauca dry product without sulphur, clearly
It is clean, dry, pulverize, 150 mesh sieves are crossed, gastrodia elata f. glauca powder is obtained；
2) weigh：Following components is weighed according to weight portion：Gastrodia elata f. glauca powder 30-50 parts, cornstarch 20-40 parts, dextrin 5-
10 parts, glucose 10-20 parts, honey 5-8 parts, sodium carboxymethylcellulose 0.5-1 parts, magnesium stearate 0-0.3 parts, essence 0-0.1
Part；
3) mix：Load weighted gastrodia elata f. glauca powder, cornstarch, dextrin, glucose and sodium carboxymethylcellulose are placed in mixed
In even container, it is sufficiently stirred for mixing, prepares mixed powder；
4) load weighted honey and essence are dissolved in edible ethanol, fully dissolving, prepare the second of honey and essence
Alcoholic solution；
5) ethanol solution of honey and essence is sprayed in mixed powder, is stirred while adding so as to uniformly made moist, it is to avoid
There is conglomeration and into pasty state；Prepare softwood；
6) obtained softwood oscillating granulator is crossed into sieve series wet granular, mesh size is 20 mesh；
7) by step 6) in the wet granular for preparing be placed in thermostatic drying chamber and be dried；
8) by the mesh of particle Jing 50 of drying and 80 mesh sieve whole grains, remove respectively compared with coarse grain and compared with particulate；
9) magnesium stearate is uniformly added into, is fully mixed；Tabletting machine, bottling, sealing prepares gastrodia elata f. glauca mouth containing
Piece.
Further, essence selects the one kind in Rosa Damascana, blueberry flavor, Peppermint essential oil.
Further, step 4) in edible ethanol volumetric concentration in 75%-85%.
Further, step 5) in softwood humidity in 10-15%.
Further, step 7) in baking temperature be 60 DEG C, drying time 5-6 hour, be dried after pellet moisture exist
2.5%-3.5%.
Compared with prior art, the present invention can be obtained including following technique effect：
1) by the production technology using buccal tablet, more traditional edible way, this lozenge has instant to the present invention,
The characteristics of active ingredient is not easily runed off.
2) the more existing health products of product of the present invention, pharmaceutical formulation, with eating mouth feel is good, good absorbing, instant etc. it is excellent
Point.
3) gastrodia elata f. glauca buccal tablet of the invention not only has obvious consumer benefits on sense organ, and this product also has can inhale
Contracture cloth area is big, absorb complete, and active component release is stable, the advantage of lasting effect length.
Certainly, the arbitrary product for implementing the present invention it is not absolutely required to while reaching all the above technique effect.
Specific embodiment
Embodiments of the present invention are described in detail below in conjunction with embodiment, thereby to the present invention how application technology hand
Section come solve technical problem and reach technology effect realize that process can fully understand and implement according to this.
The present invention provides a kind of gastrodia elata f. glauca buccal tablet, and according to mass parts following components is included：Gastrodia elata f. glauca powder 30-50 parts, jade
Rice starch 20-40 parts, dextrin 5-10 parts, glucose 10-20 parts, honey 5-8 parts, sodium carboxymethylcellulose 0.5-1 parts, stearic acid
Magnesium 0-0.3 parts, essence 0-0.1 parts；Wherein, essence selects the one kind in Rosa Damascana, blueberry flavor, Peppermint essential oil.
The present invention provides a kind of preparation method of gastrodia elata f. glauca buccal tablet, comprises the following steps：
1) gastrodia elata f. glauca powder is prepared：It is raw material to select a big, plump full, yellowish-white bright, gastrodia elata f. glauca dry product without sulphur, clearly
It is clean, dry, pulverize, 150 mesh sieves are crossed, gastrodia elata f. glauca powder is obtained；
2) weigh：Following components is weighed according to weight portion：Gastrodia elata f. glauca powder 30-50 parts, cornstarch 20-40 parts, dextrin 5-
10 parts, glucose 10-20 parts, honey 5-8 parts, sodium carboxymethylcellulose 0.5-1 parts, magnesium stearate 0-0.3 parts, essence 0-0.1
Part；Wherein, essence selects the one kind in Rosa Damascana, blueberry flavor, Peppermint essential oil；
3) mix：Load weighted gastrodia elata f. glauca powder, cornstarch, dextrin, glucose and sodium carboxymethylcellulose are placed in mixed
In even container, it is sufficiently stirred for mixing, prepares mixed powder；
4) load weighted honey and essence are dissolved in into volume fraction in 75%-85% edible ethanols, prepared by fully dissolving
Obtain honey and the mixed uniformly ethanol solution of essence；
5) ethanol solution of honey and essence is sprayed in mixed powder, is stirred while adding so as to uniformly made moist, it is to avoid
There is conglomeration and into pasty state；Softwood is prepared, softwood humidity is in 10-15%；
6) obtained softwood oscillating granulator is sieved prepared wet granular, mesh size is 20 mesh；
7) by step 6) in the wet granular for preparing be placed in thermostatic drying chamber and be dried, baking temperature is 60 DEG C, is dried
Time 5-6 hour, pellet moisture is 3% ± 0.5% after being dried；
8) by the mesh of particle Jing 50 of drying and 80 mesh sieve whole grains, remove respectively compared with coarse grain and compared with particulate；
9) magnesium stearate is uniformly added into, is fully mixed；Tabletting machine, bottling, sealing prepares gastrodia elata f. glauca mouth containing
Piece.
Embodiment 1
(1) a big, plump full, yellowish-white bright, gastrodia elata f. glauca dry tuber without sulphur is selected, cleaning dry, pulverize,
150 mesh sieve, and gastrodia elata f. glauca powder is obtained, standby.
(2) 30kg gastrodia elata f. glauca powder, 40kg cornstarch, 5kg dextrin, 15kg glucose, 0.5kg carboxymethylcellulose calciums are weighed
Sodium, is placed in mixer, is sufficiently mixed uniform, formation mixed powder.
(3) measure 20 liter of 75% edible ethanol to be placed in agitator, and weigh 5kg honey and add in the ethanol, it is fully molten
Solution.Then by spray solution in mixed powder, add while be sufficiently stirred for, make the softwood of uniform moisture, softwood humidity
For 10%.
(4) obtained softwood oscillating granulator is sieved prepared wet granular, mesh size is 20 mesh.
(5) wet granular is placed in be dried to moisture in 60 DEG C of thermostatic drying chambers and is about 3%, drying time 5-6 hour.
(6) by the mesh of particle Jing 50 of drying and 80 mesh sieve whole grains, remove respectively compared with coarse grain and compared with particulate.
(7) tabletting machine, bottling, sealing.
Embodiment 2
(1) a big, plump full, yellowish-white bright, gastrodia elata f. glauca dry tuber without sulphur is selected, cleaning dry, pulverize,
150 mesh sieve, and gastrodia elata f. glauca powder is obtained, standby.
(2) 40kg gastrodia elata f. glauca powder, 30kg cornstarch, 7kg dextrin, 20kg glucose, 1kg carboxymethylcellulose calciums are weighed
Sodium, is placed in mixer, is sufficiently mixed uniform, formation mixed powder.
(3) measure 20 liter of 75% edible ethanol to be placed in agitator, and weigh 5kg honey and add in the ethanol, it is fully molten
Solution, adds 0.05kg Rosa Damascanas, fully mixes.Then by spray solution in mixed powder, add while fully stirring
Mix, make the softwood of uniform moisture.
(4) obtained softwood oscillating granulator is sieved prepared wet granular, mesh size is 20 mesh.
(5) wet granular is placed in be dried to moisture in 60 DEG C of thermostatic drying chambers and is about 3%, drying time 5-6 hour.
(6) by the mesh of particle Jing 50 of drying and 80 mesh sieve whole grains, remove respectively compared with coarse grain and compared with particulate.
(7) 0.2kg magnesium stearates are uniformly added into, are fully mixed.
(8) tabletting machine, bottling, sealing.
Embodiment 3
(1) a big, plump full, yellowish-white bright, gastrodia elata f. glauca dry tuber without sulphur is selected, cleaning dry, pulverize,
150 mesh sieve, and gastrodia elata f. glauca powder is obtained, standby.
(2) 50kg gastrodia elata f. glauca powder, 20kg cornstarch, 10kg dextrin, 10kg glucose, 1kg carboxymethylcellulose calciums are weighed
Sodium, is placed in mixer, is sufficiently mixed uniform, formation mixed powder.
(3) measure 20 liter of 85% edible ethanol to be placed in agitator, and weigh 8kg honey and add in the ethanol, add
0.1kg Rosa Damascanas, fully dissolving.Then will be sprayed in mixed powder dissolved with the ethanol solution of honey, add while filling
Divide stirring, make the softwood of uniform moisture.
(4) obtained softwood oscillating granulator is sieved prepared wet granular, mesh size is 20 mesh.
(5) wet granular is placed in be dried to moisture in 60 DEG C of thermostatic drying chambers and is about 3%, drying time 5-6 hour.
(6) by the mesh of particle Jing 50 of drying and 80 mesh sieve whole grains, remove respectively compared with coarse grain and compared with particulate.
(7) 0.3kg magnesium stearates are uniformly added into, are fully mixed.
(8) tabletting machine, bottling, sealing.
The technique effect of the present invention is illustrated with reference to specific experimental data：
First, gastrodia elata f. glauca buccal tablet disintegration time limited inspection
According to《Chinese Pharmacopoeia》Method under (version four in 2015) disintegration time limited inspection technique (general rule 0921) tablet item
Disintegration time limited is one of quality standard check item of tablet, is to evaluate the important indicator that product absorbs in vivo.Enter
Row checks that experimental result as shown in table 1, as a result shows that sample is not disintegrated completely or dissolves in 10min, meets regulation.Crow
Rhizoma Gastrodiae buccal tablet is the health food that a direct oral cavity, esophagus, stomach, enteron aisle are fully absorbed over long distances, during relatively long disintegration
Between active material action time is increased, unit interval activity intensity slows down, the characteristics of being relatively adapted to health products and be eaten for a long time,
Compare certain commercial like product, and disintegration time is slightly long, is more beneficial for absorption of human body.
The gastrodia elata f. glauca buccal tablet disintegration time limited of table 1 checks
2nd, gastrodia elata f. glauca buccal tablet sensory evaluation
Sensory evaluation is an important quality evaluation index for sucking flake products.One good buccal tablet, either in color
Pool, local flavor, mouthfeel and structural state have strict requirements.The Analyses Methods for Sensory Evaluation Results of obtained three products of the invention is shown in Table
2, like product seen by existing market is compared to, there is significant advantage on sense organ.
The gastrodia elata f. glauca buccal tablet sensory evaluation of table 2
3rd, gastrodia elata f. glauca mouth containing flake products average cumulative dissolution rate and active ingredients Biogenic availability
According to《Chinese Pharmacopoeia》Operate under (version four in 2015) dissolution rate and drug release determination method (general rule .0931) item
Require, determined using Rotating shaker, experimental result is shown in Table 3.
The gastrodia elata f. glauca of table 3 sucks flake products average cumulative dissolution rate
The gastrodia elata f. glauca buccal tablet product active ingredient bioavilability of table 4
| Group | 20160623 | 20160627 | 20160712 | Certain commercially available prod |
| Bioavilability | 78.34% | 81.62% | 80.67% | 75.21% |
Knowable to accumulative dissolution rate and bioavilability result, the gastrodia elata f. glauca buccal tablet active release rate of the present invention
Steadily, stability is high, can maintain stable and the long period valid density；Bioavilability is high, may be implemented in smaller dose and
Less number of times of taking is issued to preferable effect.
Summary result of the test shows that the gastrodia elata f. glauca buccal tablet of the present invention not only has on sense organ significantly consumes excellent
Gesture, this product also has that absorbable distribution area is big, absorb complete, and active component release is stable, the advantage of lasting effect length.
Described above illustrates and describes some preferred embodiments of invention, but as previously mentioned, it should be understood that invention is not
Form disclosed herein is confined to, the exclusion to other embodiment is not to be taken as, and can be used for various other combinations, modification
And environment, and can be carried out by the technology or knowledge of above-mentioned teaching or association area in invention contemplated scope described herein
Change.And change that those skilled in the art are carried out and change be without departing from the spirit and scope of invention, then all should be in the appended power of invention
In the protection domain that profit is required.
Claims (7)
1. a kind of gastrodia elata f. glauca buccal tablet, it is characterised in that include following components according to mass parts：Gastrodia elata f. glauca powder 30-50 parts, corn
Starch 20-40 parts, dextrin 5-10 parts, glucose 10-20 parts, honey 5-8 parts, sodium carboxymethylcellulose 0.5-1 parts, magnesium stearate
0-0.3 parts, essence 0-0.1 parts.
2. gastrodia elata f. glauca buccal tablet according to claim 1, it is characterised in that the essence selects Rosa Damascana, blueberry fragrant
One kind in essence, Peppermint essential oil.
3. a kind of preparation method of gastrodia elata f. glauca buccal tablet, it is characterised in that comprise the following steps：
1) gastrodia elata f. glauca powder is prepared：It is raw material to select a big, plump full, yellowish-white bright, gastrodia elata f. glauca dry product without sulphur, is cleaned,
Dry, pulverize, cross 150 mesh sieves, gastrodia elata f. glauca powder is obtained；
2) weigh：Following components is weighed according to weight portion：Gastrodia elata f. glauca powder 30-50 parts, cornstarch 20-40 parts, dextrin 5-10 parts,
Glucose 10-20 parts, honey 5-8 parts, sodium carboxymethylcellulose 0.5-1 parts, magnesium stearate 0-0.3 parts, essence 0-0.1 parts；
3) mix：Load weighted gastrodia elata f. glauca powder, cornstarch, dextrin, glucose and sodium carboxymethylcellulose are placed in into mixing to hold
In device, it is sufficiently stirred for mixing, prepares mixed powder；
4) load weighted honey and essence are dissolved in edible ethanol, fully dissolving, the ethanol for preparing honey and essence is molten
Liquid；
5) ethanol solution of honey and essence is sprayed in mixed powder, is stirred while adding so as to uniformly made moist, it is to avoid occurred
Conglomeration and into pasty state；Prepare softwood；
6) obtained softwood oscillating granulator is crossed into sieve series wet granular, mesh size is 20 mesh；
7) by step 6) in the wet granular for preparing be placed in thermostatic drying chamber and be dried；
8) by the mesh of particle Jing 50 of drying and 80 mesh sieve whole grains, remove respectively compared with coarse grain and compared with particulate；
9) magnesium stearate is uniformly added into, is fully mixed；Tabletting machine, bottling, sealing prepares gastrodia elata f. glauca buccal tablet.
4. the preparation method of gastrodia elata f. glauca buccal tablet according to claim 3, it is characterised in that essence select Rosa Damascana,
One kind in blueberry flavor, Peppermint essential oil.
5. the preparation method of gastrodia elata f. glauca buccal tablet according to claim 3, it is characterised in that step 4) in edible ethanol
Volumetric concentration in 75%-85%.
6. the preparation method of gastrodia elata f. glauca buccal tablet according to claim 3, it is characterised in that step 5) in softwood humidity
In 10-15%.
7. the preparation method of gastrodia elata f. glauca buccal tablet according to claim 3, it is characterised in that step 7) in baking temperature
For 60 DEG C, drying time 5-6 hour, pellet moisture is in 2.5%-3.5% after being dried.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610910261.6A CN106615538A (en) | 2016-10-19 | 2016-10-19 | Gastrodia elata buccal tablets and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610910261.6A CN106615538A (en) | 2016-10-19 | 2016-10-19 | Gastrodia elata buccal tablets and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106615538A true CN106615538A (en) | 2017-05-10 |
Family
ID=58856436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610910261.6A Pending CN106615538A (en) | 2016-10-19 | 2016-10-19 | Gastrodia elata buccal tablets and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106615538A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1451399A (en) * | 2002-04-12 | 2003-10-29 | 冮顺奎 | Superfine gastrodia tuber and American ginseng powder buccal lozenge |
| CN1579475A (en) * | 2003-08-01 | 2005-02-16 | 熊邦培 | Sucking tablet of active tuber of elevated gastrodia |
| CN101810325A (en) * | 2009-02-25 | 2010-08-25 | 北京利乐生制药科技有限公司 | Rhizoma gastrodiae chewable tablet and preparation method thereof |
| CN101829212A (en) * | 2010-05-19 | 2010-09-15 | 北京联合大学生物化学工程学院 | Buccal tablet and preparation method thereof |
| CN104083642A (en) * | 2014-07-24 | 2014-10-08 | 陕西百圣生物工程有限公司 | Gastrodia elata micro-powder buccal tablet and preparation process thereof |
-
2016
- 2016-10-19 CN CN201610910261.6A patent/CN106615538A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1451399A (en) * | 2002-04-12 | 2003-10-29 | 冮顺奎 | Superfine gastrodia tuber and American ginseng powder buccal lozenge |
| CN1579475A (en) * | 2003-08-01 | 2005-02-16 | 熊邦培 | Sucking tablet of active tuber of elevated gastrodia |
| CN101810325A (en) * | 2009-02-25 | 2010-08-25 | 北京利乐生制药科技有限公司 | Rhizoma gastrodiae chewable tablet and preparation method thereof |
| CN101829212A (en) * | 2010-05-19 | 2010-09-15 | 北京联合大学生物化学工程学院 | Buccal tablet and preparation method thereof |
| CN104083642A (en) * | 2014-07-24 | 2014-10-08 | 陕西百圣生物工程有限公司 | Gastrodia elata micro-powder buccal tablet and preparation process thereof |
Non-Patent Citations (1)
| Title |
|---|
| 田洁等: "天麻含片的毒理和免疫功能实验研究", 《公共卫生与预防医学》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105504081B (en) | A kind of method of polysaccharide component leaching rate in raising dendrobium candidum | |
| Chinma et al. | Effect of addition of germinated moringa seed flour on the quality attributes of wheat‐based cake | |
| CN101926432A (en) | Coix seed snack health-care food and processing technique thereof | |
| CN103431328B (en) | Natural jackfruit powder and preparation method thereof | |
| CN101690583B (en) | Parslane herb nutritive food | |
| CN106615538A (en) | Gastrodia elata buccal tablets and preparation method thereof | |
| CN106819678A (en) | Black fungus rich in selenium beverage and preparation method thereof | |
| CN101815443B (en) | Foodstuff of tablets or capsules | |
| CN105994908A (en) | Tableting sugar and preparation method and application thereof | |
| CN109430879A (en) | A kind of processing technology of selenium vitamin A vitamin C-vitamin E tablets | |
| CN103262955B (en) | A kind of American cockroach nymph special feed and preparation method thereof | |
| CN108245539A (en) | A kind of preparation method of liver Soviet Union capsule | |
| CN1543854A (en) | Barbecue seasoning flavor and preparation method thereof | |
| JP3872369B2 (en) | Processed honoki leaves and method for producing the same | |
| CN1916063A (en) | Method for producing starch of acorn rich in selenium | |
| CN104982899A (en) | Honey sesame paste and preparation method thereof | |
| CN109497230A (en) | A kind of New Tartary-buckwheat Tea | |
| CN107714668A (en) | The moistureproof antitackiness agent and its application process of one Plant Extracts tablet | |
| CN101664140A (en) | Shepherds-purse nutritional food | |
| CN107772241A (en) | A kind of arrowhead health caring noodles | |
| CN102836380B (en) | A kind of Formica fusca watered pill containing Chinese medicine and preparation method thereof | |
| CN105325838A (en) | Collateral-dredging muscle-tendon-relaxing solid instant eight-ingredient porridge and preparation method thereof | |
| CN106616600A (en) | Chimonobambusa quadrangularis shoot nutrition formula and preparation method thereof | |
| CN109744535A (en) | A kind of functional particles composition with Soboring-up liver-protecting | |
| CN105166666A (en) | Trepang solid convenient eight-ingredient porridge and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170510 |