CN106614579A - Disinfectant and application thereof - Google Patents
Disinfectant and application thereof Download PDFInfo
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- CN106614579A CN106614579A CN201610889118.3A CN201610889118A CN106614579A CN 106614579 A CN106614579 A CN 106614579A CN 201610889118 A CN201610889118 A CN 201610889118A CN 106614579 A CN106614579 A CN 106614579A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen
- A01N35/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen containing a carbon-to-nitrogen double bond
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
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Abstract
The invention relates to preparation of a polyhexamethylene biguanidine imide phenylenediimine phenol ionic compound of a disinfectant and application thereof. The bacteria inhibiting and sterilizing action mechanism of the disinfectant is characterized in that the surface of the ionic compound is provided with positive charges, and free protons are provided; on one hand, by combining with transpeptidase and pyrophosphatase, the transpeptidation, crosslinking, synthesis and the like of peptidoglycan in the bacterial cell wall are blocked; on the other hand, the positive charges at the surface of the macromolecule can adsorb bacteria with negative charges, and are gathered to the bacteria surface at high concentration, and the metabolism of the bacteria is inhibited. The disinfectant has the advantages that the ionic compound and applicable auxiliary materials are prepared into the solution type disinfection liquid or solid disinfectant (tablets, capsules, granules and the like) or semi-solid disinfectants (gel and ointment); the disinfectant can be used for disinfecting tissues or organs of a human body, and disinfecting medical examination operation apparatuses, daily living articles, environments and the like.
Description
Technical field
The invention belongs to medical treatment, day common disinfectantses synthesis and its preparation technique and application.
Background technology
Peptidoglycan is present in the cell wall of the gram positive bacteria in eubacteria and gram negative bacteria, is many coccuses
The principal component of cell wall.Peptidoglycan as contained by gram-positive cocci (g+) cell wall accounts for the 50-80% of dry weight by n- acetyl Pus
Grapes glucosamine and the logical capsicum red pigment of n- acetylmuramic acids are crossed β -1,4 glycosidic bonds and are formed by connecting, and are crosslinked by peptide chain between sugar chain, constitute steady
Fixed network structure, the short-sighted coccus species of peptide chain length is different and different, and the Peptidoglycan contained by Gram-negative coccus (g-) cell wall is accounted for
But the 5-20% of dry weight its dissacharide units are not l-lys but raceme for the 3rd of tetrapeptide tail as gram positive bacteria
Meso diaminopimelic acid.
The condition of Peptidoglycan synthesis is two main carriers, i.e. uracil diphosphonic acid（Uridine Diphosphate,
UDP）React under transpeptidase and pyrophosphatase effect with bactoprenol lipid carrier.Disinfectant involved in the present invention is poly- six sub-
Methyl biguanide imines neighbour's benzene diimine phenol ionic compound reacts with transpeptidase and pyrophosphatase, therefore, Peptidoglycan is synthesized
Turn the blocking of peptide, dephosphorization acid esters and cross-linking step, antibacterial normal growth is destroyed, so as to suppressing or and killing antibacterial.
By positron-electron collision principle, i.e., disinfectant institute is positively charged can actively attract have negative charge with absorption surface
Object, such as antibacterial, virus protein, wall, glass, equipment and utensil surfaces externally and internally.Positron-electron mutually attracts, and makes sterilization
Agent molecule is contacted with antibacterial, virus protein, produces killing action.The disinfectant can increase the permeability of pathogen cells film,
The surface tension of pathogen is reduced, causes important enzyme and nutrient substance leakage, make breathing and the glycolysiss mistake of pathogenic microorganism
Journey is obstructed, tropina degeneration, and water penetrates into into thalline, thalline is ruptured or is dissolved and make pathogen dead, sterilization is presented and kills
Virus function.Cationic surfactant anti-bacteria and anti-virus spectrum is wide, and effect is fast, low concentration not only can kill gram positive bacteria,
Gram negative bacteria, it is also effective to virus, mycete, funguses.
A kind of mechanism of action of disinfectant bacteriostasis and sterilization involved in the present invention is：The ionic compound surface positively charged
Lotus and free protons can be provided, on the one hand, by the way that with reference to transpeptidase and pyrophosphatase, Peptidoglycan turns peptide in blocking bacteria cell wall
The steps such as crosslinking synthesis；On the other hand, macromolecule surface positive charge adsorbs electronegative antibacterial, and high concentration is gathered in thalline table
Face, suppresses the metabolism of antibacterial.The ionic compound is prepared into solution-type disinfectant solution or solid sterilizing with suitable adjuvant
Agent（Tablet, capsule, granule etc.）Or semi-solid（Gel, paste）Disinfectant, can be used for human body respectively tissue or organ disinfection,
Can be used for the sterilization such as medical examination operating theater instruments, daily living article, environmental health and bio-safety.
Polyhexamethylene guanidine（PHMG）With broad-spectrum, low valid density, work fast, it is stable in properties, be soluble in
The premium properties of water, can use at normal temperatures, it is long-term it is antibacterial, have no side effect, non-corrosiveness, and it is colourless, odorless, nontoxic, do not fire,
It is not quick-fried, the features such as, be a kind of environment-friendly multipurpose new polymerss, have extremely in industrial, agriculture, medical and daily life
Extensive purposes.But PHMG belongs to low effect disinfectantses, existing can not thoroughly kill phenomenon to part antibacterial, virus, meanwhile, PHMG
Easily moisture absorption itself, prepares and inconvenient using process.
O-phthalaldehyde(OPA)（OPA）It was in the past a kind of important pharmaceutical-chemical intermediate, found that it was used for from Alaf in 1994
The sterilization of medical endoscope has after good effect, external to study very active to OPA sterilizing functions, is developed into one
Plant new and effective disinfectant and obtain the certification of U.S. FDA.With at present in the disinfectant glutaraldehyde phase that medical institutions are widely used
Than the fungicidal spectrum of o-phthalaldehyde(OPA) is wider, and concentration is lower, and sterilizing time is shorter, and zest is less, and corruption is weaker.Closely
The Ji Nian U.S., Canada, Japan and other countries progressively replace glutaraldehyde as efficient medical disinfectant of new generation with it.But
OPA is more sensitive to temperature, easily protein such as skin surface need to be dyed into silver gray using process, with respect to PHMG in cryopreservation
There are certain irritation on mucous membrane, hypotoxicity.
New disinfectant poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound has had both polyhexamethylene
The advantage of guanidine and o-phthalaldehyde(OPA), turn avoid the shortcoming of the two.Therefore, it is adjacent by noval chemical compound poly hexamethylene biguanide imines
The disinfectant environmental protection of benzene diimine phenol ionic compound preparation, low toxicity addiction, sterilizing power are strong, non-stimulated, stable at normal temperatures, fit
For partes corporis humani position or organ disinfection, it can also be used to which hospital's hygiene medical treatment apparatus, daily living article, environment etc. are sterilized.
The content of the invention
The present invention relates to a kind of preparation of disinfectant poly hexamethylene biguanide imines neighbour benzene diimine phenol ionic compound
And its preparation technique research.The new disinfectant chemical structural formula is：
Or。
The new disinfectant is to provide proton positively charged high molecular polymer, by the load of destruction synthesis Peptidoglycan
Body uracil diphosphonic acid and polyprene phosphate ester, play Peptidoglycan synthesis in prevention bacteria cell wall, so as to suppress antibacterial numerous
Reproductive growth, meanwhile, by positively charged high molecular polymer, adsorb electronegative antibacterial, can high concentration be gathered in thalline table
Face, affects the metabolism of antibacterial, so as to kill antibacterial.The new disinfectant is prepared into solution-type sterilization with suitable adjuvant
Liquid or solid disinfecting agent（Tablet, capsule, granule etc.）Or semi-solid（Gel, paste）Disinfectant, can be used for partes corporis humani position
Or organ disinfection, it can also be used to hospital's hygiene medical treatment apparatus, daily living article, environment etc. are sterilized.
The technical scheme is that what is be achieved in that：
I new disinfectant by o-phthalaldehyde(OPA) and para-aminophenol reaction after gained reactant, then with poly hexamethylene biguanide
Polyreaction gained；
II present invention is with noval chemical compound poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound and biocompatibility
Suitable adjuvant is prepared into solution-type disinfectant solution or solid disinfecting agent（Tablet, capsule, granule etc.）Or semi-solid gel, cream
Shape disinfectant.Described solution-type disinfectant solution is by poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound
0.05% ~ 5% with the suitable Sodium Chloride of biocompatibility or disodium hydrogen phosphate（Potassium）Or sodium dihydrogen phosphate（Potassium）Or boric acid or boron
Sand one or more combination buffering isosmotic solution composition；Described solid disinfecting agent（Tablet, capsule, granule etc.）Be by
Poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound 0.05% ~ 5% and the suitable solubility of biocompatibility
Starch or microcrystalline cellulose or Carboxymethyl cellulose sodium or magnesium stearate or Pulvis Talci one or more combination, Jing granulations,
Tabletting is formed；Described semi-solid gel disinfectant is by poly hexamethylene biguanide imines neighbour's benzene diimine phenol ion combination
Thing 0.05% ~ 5% and the suitable adjuvant of biocompatibility such as Acritamer 940 or hydroxypropyl methylcellulose or sodium alginate or shitosan
Or glycerol or glycerol or triethanolamine, Sodium Chloride one or more combination, it is adequately mixed, dissolves, stirs preparation
Form；Described semi-solid paste disinfectant, by poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound 0.05%
~ 5% with the suitable adjuvant of biocompatibility such as vaseline or lanoline or liquid paraffin or hydroxypropyl methylcellulose or sodium alginate
Or shitosan or glycerol or glycerol or triethanolamine, Sodium Chloride one or more combination, be adequately mixed, dissolve,
Stirring is prepared from.
Specifically preparation process is：
I method 1,1) new disinfectant first step reaction
2) the new disinfectant second step reaction
1) the new disinfectant first step reaction of method 2
2) the new disinfectant second step reaction
II method one：Solution-type disinfectant solution be by poly hexamethylene biguanide imines neighbour benzene diimine phenol ionic compound 0.05% ~
5% and 0.9% Sodium Chloride or disodium hydrogen phosphate（Potassium）Or sodium dihydrogen phosphate（Potassium）Or boric acid or Borax one or more group
Buffering isosmotic solution is closed, the scope of pH value 4.5 ~ 7.5, aseptic filtration or 115 DEG C ~ 121 DEG C 15 ~ 30min of steam sterilization are adjusted, is filled
Dress, obtains final product.
Method two：Described solid disinfecting agent（Tablet, capsule, granule etc.）It is by poly hexamethylene biguanide imines neighbour's benzene two
Imines phenol ionic compound 0.05% ~ 5% and the suitable soluble starch of biocompatibility or microcrystalline cellulose or methylol fibre
The plain sodium of dimension or magnesium stearate or Pulvis Talci one or more combination, by 40 ~ 65% ethanol solution or purified water wet method or
After spraying or dry granulation, mesh ~ 40 mesh of Jing 20 sieves, after 50 DEG C ~ 80 DEG C drying control moisture are less than 1%, then mesh ~ 40 of Jing 20
Mesh granulate, directly packaging particulate disinfection agent, be sub-packed in more capsule, obtain final product capsule fortreating AIDS sterilize in, by tabletting machine,
Obtain final product tablet disinfectant.
Method three：Described semi-solid gel disinfectant be by poly hexamethylene biguanide imines neighbour benzene diimine phenol from
Sub- compound 0.05% ~ 5% and the suitable adjuvant of biocompatibility such as Acritamer 940 or hydroxypropyl methylcellulose or sodium alginate or
Shitosan or glycerol or glycerol, Sodium Chloride one or more combination, are adequately mixed, dissolve, stir, aseptic filtration
Or after 115 DEG C ~ 121 DEG C 15 ~ 30min of steam sterilization, pH to 4.5 ~ 7.5 being adjusted by triethanolamine, subpackage is obtained final product.
Method four：Described semi-solid paste disinfectant, by poly hexamethylene biguanide imines neighbour's benzene diimine phenol ion
Compound 0.05% ~ 5% and the suitable adjuvant of biocompatibility such as vaseline or lanoline or liquid paraffin or hydroxypropyl methylcellulose
Element or sodium alginate or shitosan or glycerol or glycerol or triethanolamine, Sodium Chloride one or more combination, Jing fills
Divide mixing, stirring, after heated hot melt and dissolved solution, 80 DEG C ~ 121 DEG C 15 ~ 60min of moist heat sterilization of Jing, 100 mesh are filtered, cooling divides
Dress, obtains final product.
Advantages of the present invention：
1st, with double sterilization effect, on the one hand, by poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound
The carrier uracil diphosphonic acid and polyprene phosphate ester of destruction synthesis Peptidoglycan, plays Peptidoglycan in prevention bacteria cell wall
Synthesis, so as to suppress bacterial reproduction to grow；On the other hand, it is sub- by positively charged high molecular polymer poly hexamethylene biguanide
Amine neighbour's benzene diimine phenol ionic compound, adsorbs electronegative antibacterial, can high concentration be gathered in phage surface, affect antibacterial
Metabolism, so as to kill antibacterial；
2nd, poly hexamethylene biguanide imines neighbour benzene diimine phenol ionic compound new disinfectant sterilization effect is better than poly-
Hexamethylene biguan-ide and o-phthalaldehyde(OPA), environmental protection, low toxicity addiction, sterilizing power are strong, non-stimulated, stable at normal temperatures, it is adaptable to many models
Enclose, can be used for partes corporis humani position or organ disinfection, it can also be used to which hospital's hygiene medical treatment apparatus, daily living article, environment etc. disappear
Poison.
Specific embodiment
Embodiments of the invention, but the complete not limited to this of present disclosure are described below.
I embodiment 1：
O-phthalaldehyde(OPA) reacts gained reactant, then 2 with para-aminophenol:1 must poly- six with poly hexamethylene biguanide polyreaction
Methylene biguanide imines neighbour's benzene diimine phenol ionic compound.
1) first step reaction
2) second step reaction
Embodiment 2：Gained reactant after being reacted by o-phthalaldehyde(OPA) and para-amino benzoic acid, then 1:1 and poly hexamethylene biguanide
Polyreaction obtains poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound.
1) first step reaction
2) second step reaction
II embodiment 1：Pharmaceutical solutionses application
Prescription is constituted
| Poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound | 0.2g |
| Sodium Chloride | 9.0g |
| 0.1mol/L sodium hydroxide solutions adjust in right amount pH to 6.5 | |
| Water for injection | Add to 1000ml |
Each material is weighed by recipe quantity precision, PHMG, Sodium Chloride is completely dissolved in appropriate water for injection, stirring and evenly mixing, plus
When water is to about 1000ml, take 0.1mol/L sodium hydroxide solutions adjust in right amount pH to 6.5, constant volume, then 0.45 m and 0.22 m without
Bacterium is filtered, and subpackage is obtained final product.
Embodiment 2：Tablet formulation application
Prescription is constituted
| Poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound | 2g |
| Soluble starch | 60.0g |
| Hydroxypropyl methylcellulose sodium | 18.0g |
| Microcrystalline cellulose | 20.0g |
| Magnesium stearate | 0.1g |
The poly hexamethylene biguanide imines neighbour's benzene diimine phenol Jing after 65 DEG C of drying control moisture are less than 1% is weighed by recipe quantity
Ionic compound, soluble starch, microcrystalline cellulose, Carboxymethyl cellulose sodium, magnesium stearate are sufficiently mixed, by common 100g processed,
Direct compression, every 5g obtains final product tablet disinfectant.
Embodiment 3：Capsule preparations application
Prescription is constituted
| Poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound | 4g |
| Soluble starch | 52.0g |
| Hydroxypropyl methylcellulose sodium | 25.0g |
| Microcrystalline cellulose | 22.0g |
| Magnesium stearate | 0.1g |
| Purified water | In right amount |
It is fine poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound, soluble starch, crystallite to be weighed by recipe quantity
Dimension, Carboxymethyl cellulose sodium, magnesium stearate are sufficiently mixed, after purified water wet method or spraying or dry granulation, the mesh mistakes of Jing 40
Sieve, after 80 DEG C of drying control moisture are less than 1%, then the mesh granulate of Jing 30,100g processed altogether, 2g/ grains, directly packaging granule disappear
Toxic agent.
Embodiment 4：Granular preparation application
Prescription is constituted
| Poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound | 4g |
| Soluble starch | 52.0g |
| Hydroxypropyl methylcellulose sodium | 25.0g |
| Microcrystalline cellulose | 22.0g |
| Magnesium stearate | 0.1g |
| 60% ethanol solution | In right amount |
It is fine poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound, soluble starch, crystallite to be weighed by recipe quantity
Dimension, Carboxymethyl cellulose sodium, magnesium stearate are sufficiently mixed, and after 60% ethanol solution spray-drying process, the mesh of Jing 40 sieves,
After 65 DEG C of drying control moisture are less than 1%, then the mesh granulate of Jing 30,100g processed, 5g/ bags altogether, directly pack particulate disinfection
Agent.
Embodiment 5：Gel preparation application
Prescription is constituted
| Poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound | 0.2g |
| Glycerol | 8.0g |
| Sodium Chloride | 9.0g |
| Triethanolamine/0.1mol/LNaOH solution | 8ml |
| Acritamer 940 | 10g |
| Distilled water is added to | 1000g |
(1) appropriate distilled water is taken, is under high velocity agitation sprinkled in Acritamer 940 powder, continue to stir until powder is completely dispersed
To in solvent, triethanolamine is added under stirring at low speed, make into gel-type vehicle, it is standby.
(2) poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound, glycerol, Sodium Chloride are dissolved in into a small amount of steaming
In distilled water, this solution is added in gel-type vehicle under agitation, add water to full dose, stirred evenly and obtain final product.
Embodiment 6：Unguentum
Prescription
| Poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound | 0.5g |
| Glycerol | 12.0g |
| Vaseline | 50.0g |
| Lanoline | 30g |
| Liquid paraffin is extremely | 1000g |
Above-mentioned each material is weighed by recipe quantity, by vaseline, lanoline after 65 DEG C of hot melts, poly hexamethylene biguanide imines is added
Adjacent benzene diimine phenol ionic compound, glycerol, liquid paraffin are sufficiently mixed, stir, and take advantage of hot 100 mesh to filter, and are cooled to room temperature,
Subpackage, obtains final product.
It is attached：Three kinds of solution disinfection agent bactericidal effect contrast tests
Three kinds of solution disinfection agent bactericidal effect contrast test tables
Claims (10)
1. a kind of disinfectant and its preparation, it is characterised in that the disinfectant is synthesized with para-aminophenol by o-phthalaldehyde(OPA)
Adjacent benzene diimine phenol is obtained, then poly hexamethylene biguanide imines neighbour's benzene diimine phenol is obtained with poly hexamethylene biguanide synthesis
Ionic compound, and the preparation for possessing multiple use is made, its structural formula is：
Or。
2. a kind of disinfectant and its preparation as described in claim 1, it is characterised in that：The disinfectant be o-phthalaldehyde(OPA) with it is right
Gained reactant after amino-phenol reaction, then with 1:1 or 2:1 mol ratio and poly hexamethylene biguanide polyreaction gained.
3. a kind of sterilization agent formulation as described in claim 1, it is characterised in that：Described disinfectant preparation, can be solution-type
Disinfectant solution or solid disinfecting agent（Tablet, capsule, granule etc.）Or semi-solid gel or paste disinfectant.
4. a kind of sterilization agent formulation as described in claim 3, it is characterised in that：Described solution-type disinfectant solution is by poly- six methylene
Base biguanide imines neighbour's benzene diimine phenol ionic compound 0.05% ~ 5% and 0.9% Sodium Chloride or disodium hydrogen phosphate（Potassium）Or phosphoric acid
Sodium dihydrogen（Potassium）Or boric acid or Borax one or more combination buffering isosmotic solution composition.
5. a kind of sterilization agent formulation as described in claim 3, it is characterised in that：Described solid disinfecting agent tablet is sub- by poly- six
Methyl biguanide imines neighbour's benzene diimine phenol ionic compound 0.05% ~ 5% and suitable supplementary product starch or microcrystalline cellulose or hydroxyl first
Base sodium cellulosate or magnesium stearate or Pulvis Talci one or more combination, Jing granulations, tabletting are formed.
6. a kind of sterilization agent formulation as described in claim 3, it is characterised in that：Described capsule is sub- by poly hexamethylene biguanide
Amine neighbour's benzene diimine phenol ionic compound 0.05% ~ 5% and suitable adjuvant soluble starch or microcrystalline cellulose or methylol fibre
The plain sodium of dimension or magnesium stearate or Pulvis Talci one or more combination, Jing granulations, are dried, are sub-packed in capsule and form.
7. a kind of sterilization agent formulation as described in claim 3, it is characterised in that：Described granule is sub- by poly hexamethylene biguanide
Amine neighbour's benzene diimine phenol ionic compound 0.05% ~ 5% and suitable supplementary product starch or microcrystalline cellulose or Carboxymethyl cellulose sodium
Or magnesium stearate or Pulvis Talci one or more combination, Jing granulations, dry packing are formed.
8. a kind of sterilization agent formulation as described in claim 13, it is characterised in that：Described semi-solid gel disinfectant, by
Poly hexamethylene biguanide imines neighbour's benzene diimine phenol ionic compound 0.05% ~ 5% is with the suitable adjuvant of biocompatibility as blocked
Ripple nurse 940 or hydroxypropyl methylcellulose or sodium alginate or shitosan or glycerol or glycerol or triethanolamine, Sodium Chloride one kind
Or more than one combination, it is adequately mixed, dissolves, stirs and be prepared from.
9. a kind of sterilization agent formulation as described in claim 3, it is characterised in that：Described semi-solid paste disinfectant, by gathering
Hexamethylene biguan-ide imines neighbour's benzene diimine phenol ionic compound 0.05% ~ 5% and for example all scholars of the suitable adjuvant of biocompatibility
Woods or lanoline or liquid paraffin or hydroxypropyl methylcellulose or sodium alginate or shitosan or glycerol or glycerol or three ethanol
Amine, Sodium Chloride one or more combination, is adequately mixed, dissolves, stirring and be prepared from.
10. as described in claim 1 a kind of disinfectant and its preparation application, it is characterised in that：The multi-purpose disinfectant system
Agent, can be used for partes corporis humani position or organ, hospital's hygiene medical treatment apparatus, daily living article, public environment and bio-safety
Sterilization.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110041199A (en) * | 2019-01-23 | 2019-07-23 | 中山大学 | A kind of monomer containing o-phthalaldehyde, by the polymer and preparation method and application of monomer preparation |
| CN114342950A (en) * | 2021-12-31 | 2022-04-15 | 上海明涌新材料有限公司 | Macromolecular guanidine salt disinfectant and preparation method and preparation thereof |
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| CN110041199B (en) * | 2019-01-23 | 2021-07-09 | 中山大学 | Monomer containing o-phthalaldehyde, polymer prepared from monomer, preparation method and application |
| CN114342950A (en) * | 2021-12-31 | 2022-04-15 | 上海明涌新材料有限公司 | Macromolecular guanidine salt disinfectant and preparation method and preparation thereof |
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