CN106606454A - Cosmetic using peptide-rich undifferentiated white mulberry cells as basic component - Google Patents
Cosmetic using peptide-rich undifferentiated white mulberry cells as basic component Download PDFInfo
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- CN106606454A CN106606454A CN201710019927.3A CN201710019927A CN106606454A CN 106606454 A CN106606454 A CN 106606454A CN 201710019927 A CN201710019927 A CN 201710019927A CN 106606454 A CN106606454 A CN 106606454A
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- 239000005864 Sulphur Substances 0.000 description 1
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- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
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- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 150000008131 glucosides Chemical class 0.000 description 1
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- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
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- 229960000201 isosorbide dinitrate Drugs 0.000 description 1
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- 239000008274 jelly Substances 0.000 description 1
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- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 description 1
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- XFHJDMUEHUHAJW-UHFFFAOYSA-N n-tert-butylprop-2-enamide Chemical class CC(C)(C)NC(=O)C=C XFHJDMUEHUHAJW-UHFFFAOYSA-N 0.000 description 1
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Epidemiology (AREA)
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- Dermatology (AREA)
- Engineering & Computer Science (AREA)
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- Botany (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of daily chemicals, and relates to a cosmetic using peptide-rich undifferentiated white mulberry cells as the basic component. The invention provides a composition for a cosmetic, the composition at least contains (a) extracted undifferentiated white mulberry cells, (b) a peptide mixture containing carnosine, rice peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptide and oligopeptide-1 and (c) a solvent suitable for the cosmetic. The composition for the cosmetic does not contain pigments, at the same time, has more antioxidation and anti-free radical components, and thus can stimulate skin regeneration, and enables skin to be brighter.
Description
This application claims submitting French National Institute of Industrial Property, Application No. 1654501, denomination of invention on May 20th, 2016
For the priority of the foreign patent application of " cosmetics of composition based on the Morus alba rich in peptide ", entire contents are by quoting
It is incorporated in the present application.
Technical field
The invention belongs to daily chemical products field, the concrete composition based on the undifferentiated Morus alba cell rich in peptide mixer
Cosmetics.
Background technology
Existing market has been proposed the cosmetics of the composition based on plant extraction composition in a large number, be mainly used in defying age,
Crease-resistant or skin regeneration.
Such as, with the cosmetics of composition based on mulberry extract, particularly Morus alba extract, already registered with
In EP296923 files, because the extract of mulberry can produce a water lipid layer, the composition can produce desalination color
Element or the effect of antiinflammatory.
A kind of brand-new cosmetics and/or dermatological composition are elaborated in EP997140 files, wherein combining Mulberry
Tree extract component and at least one salicylic acid derived ingredient, the composition has the effect of desalination pigment.
A kind of cosmetic composition for protecting local skin to resist free radical is elaborated in US7195787 files, should
Composition has effect that is sun-proof and protecting the skin from atmospheric pollution injury.The composition contains three kinds of free radical resisting preparations, its
Middle one kind is mulberry extract.
Meanwhile, a kind of composition for skin clean based on protein is also illustrated in EP1531782 files,
Protein or composition containing enzymatic activity that the composition is combined comprising a class with copper, (are carried with mixed plant extract including mulberry
Take thing) and disodium EDTA form composition.
The present inventor now proposes a kind of cosmetic composition, and it does not contain pigment, while and possessing more antioxidation and resisting certainly
By the composition of base, skin regeneration can be stimulated, make skin brighter.
The content of the invention
It is an object of the invention to provide a kind of cosmetic composition, it does not contain pigment, while and possessing more antioxidation
With the composition of free radical resisting, skin regeneration can be stimulated, make skin brighter.
To realize the purpose of the present invention, the present invention provides following technical scheme.
The invention provides a kind of cosmetic composition, includes at least：
A undifferentiated Morus alba cell that () extracts,
The peptide mixer of (b) containing carnosine, rice peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides and oligopeptide -1, and
C () is applied to the solvent of cosmetics.
The undifferentiated Morus alba cell is the Morus alba cell for not being grinded up or fully not pulverized, while being most easily dispersed in
Suitable for the solvent of cosmetics.
The peptide mixer contains carnosine, rice peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides and oligopeptide -1.Wherein, flesh
Peptide is a kind of dipeptides (CAS numberings being made up of beta Alanine and histidine：305-84-0), its molecular weight be 226g, white powder
Last shape.
Rice peptide be rice protein Jing after albumen enzyme effect, then it is specially treated obtained from protein hydrolysate,
For solution state, anti-corrosion agent (such as antimicrobial agent and antifungal agent containing the rice extract less than 1% and less than 1%
Agent).Rice peptide solution of the present invention is entered with the name for hydrolyzing Oryza sativa L. extraction protein (Thymophytane) by Vincience
What marketing was sold.
Asp is the abbreviation of alanine in Ala-Asp-Leu-Lys-Pro-Thr hexapeptides；Lys is the abbreviation of Populus davidiana acid；Leu
It is leucic abbreviation；Lys is the abbreviation of lysine；Pro is the abbreviation of proline；And Thr is the abbreviation of threonine), i.e.,
Ala-Asp-Leu-Lys-Pro-Thr hexapeptides are alanine-Populus davidiana acid-LKP-threonine hexapeptide.It
It is a kind of active component of use in facial cream.This composition is studied and treatment magazine (2013) 19 in International Peptide:217-224
In, by Anna Ao Lejienike et al. delivered entitled " mass spectrography is for alanine-Populus davidiana acid-leucine-lysine-
There is related description (this article can be found in Springerlink.com) in one text of the measure of proline-threonine hexapeptide ".
Oligopeptide -1 is a kind of peptide containing less than 60 aminoacid.It is also considered as a kind of little albumen or epidermal growth factor
Son.Oligopeptide -1 is by BioOrganic Concepts companies (California, USA Santa Fe Spring this, postcode CA 90670)
Sold with entitled Dermatien EGF, the product is containing 25% (weight) ammonium sulfate and few less than 0.01% (weight)
The form of the aqueous solution of peptide -1.
Peptide mixer is preferably included less than 60 aminoacid, more preferably less than 40 aminoacid, less than 10 aminoacid
Peptide mixer is optimal.Peptide mixer is preferably more than 50% weight, more preferably more than 70% weight and less than 10 aminoacid.
Cosmetic composition of the present invention also includes the solvent suitable for cosmetics, in particular for local.
Cosmetic composition of the present invention preferably comprises the undifferentiated Morus alba for extracting of 0.0005%-20% dry weights
Cell.More preferably 0.001%-10% dry weights, the preferably undifferentiated Morus alba cell for extracting of 0.001%-1% dry weights.
According to the present invention, it will be appreciated by those skilled in the art that the preferred mixing of the undifferentiated Morus alba cell that goes out of said extracted or
It is dispersed in suitable for the solvent of cosmetics, is particularly preferably scattered in glycerol.
Cosmetic composition of the present invention preferably also comprising 0.0001%-10% dry weights containing carnosine, rice peptide,
The peptide mixer of Ala-Asp-Leu-Lys-Pro-Thr hexapeptides and oligopeptide -1.More preferably 0.0001%-5% dry weights, preferably
Peptide containing carnosine, rice peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides and oligopeptide -1 mixing of 0.0002%-1% dry weights
Thing.
According to the present invention, it will be appreciated by those skilled in the art that described containing carnosine, rice peptide, Ala-Asp-Leu-Lys-
The peptide mixer of Pro-Thr hexapeptides and oligopeptide -1 is preferably in same phase, particularly with the undifferentiated Morus alba cell for extracting
Same lipid phase.
In the peptide mixer containing carnosine, rice peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides and oligopeptide -1, flesh
The weight of peptide accounts for peptide mixer weight 1%-95%, preferably accounts for 5%-90%, more preferably accounts for 50%-85%；The weight of rice peptide
Peptide mixer weight 1%-50% is accounted for, 3%-40% is preferably accounted for, 4%-20% is more preferably accounted for；Ala-Asp-Leu-Lys-Pro-
The weight of Thr hexapeptides accounts for peptide mixer weight 1%-50%, preferably accounts for 3%-40%, more preferably accounts for 4%-20%；Oligopeptide -1
Weight accounts for peptide mixer weight 1%-50%, preferably accounts for 3%-40%, more preferably accounts for 4%-20%.
The undifferentiated Morus alba cell dia for extracting of the present invention is average≤and 200 μm, preferably≤100 μm, in some realities
In applying example, the undifferentiated Morus alba cell dia for extracting is less than 5 μm.
The present invention is not particularly limited to the extracting method of undifferentiated Morus alba cell.In some embodiments, it is described to carry
The undifferentiated Morus alba cell for taking out is operated when extracting in the incubator of carbon dioxide, while alternately 30 minutes little to 6
When illumination process and 15 minutes to 2 hours non-illumination process.Need after the illumination process for carrying out 30 minutes to 6 hours into
The process of the row non-illumination of 5 minutes to 2 hours, is then illuminated again process.
It is big in the peptide mixer containing carnosine, rice peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides and oligopeptide -1
Rice peptide is preferably the rice peptide for hydrolyzing.More preferably single Oryza sativa L. hydrolyzed protein or many Oryza sativa L. hydrolyzed proteins, especially many Oryza sativa L. hydrolysis
Albumen.
Preferably, the solvent suitable for cosmetics is glycerol and/or glycerol.
Cosmetic composition of the present invention has following at least one purposes：
Antioxidation and/or free radical resisting；
Defence ultraviolet (UV-A and/or UV-B), especially UV-B (UV-B)；
Aging is prevented, can especially be limited or be slowed down face skin and relax, reduce face's microgroove, and/or delay microgroove
Produce；
Keep skin water profit；
Strengthen the oxidation resistance of skin；
Guarantee that endocrine is stablized, promote homoiostasiss；
Reduce coming off for keratinocyte, it is ensured that the cohesiveness of horn cell；
Hyperproliferative skin cell, promotes and dramatically speeds up cell turnover；
Promote the differentiation of epidermis cell；
Promote reepithelialization；
Promote and/or accelerate regenerating for collagen protein.
Preferably, the cosmetic composition be used for facial skin, cheek skin, cheekbone skin, at crows-feet, decree
At stricture of vagina, tear ditch, particularly eye part skin.And/or
The cosmetic composition is in white shape, paste, gel shape, emulsus, working fluid mixture, solid or semisolid
Mixture, stick-like, bar-shaped, little tubulose, solid or semi-solid gel-type ....
The invention provides a kind of undifferentiated Morus alba cell that extracts including at least (a) of cosmetic composition, (b) contain
The peptide mixer and (c) of carnosine, rice peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides and oligopeptide -1 is applied to cosmetics
Solvent.Cosmetic composition of the present invention does not contain pigment, while and possessing the composition of more antioxidation and free radical resisting, energy
Stimulate skin regeneration, make skin brighter.
Description of the drawings
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
The accompanying drawing to be used needed for having technology description is briefly described.
Figure 1A shows untreated regeneration epidermal tissue structure chart；Figure 1B shows and added toward regeneration epidermis within 24 hours
Regeneration epidermal tissue structure chart after 0.5% activating agent；Fig. 1 C show the activating agent of the addition 1% toward epidermis within 24 hours
Regeneration epidermal tissue structure chart afterwards；With Fig. 1 D show within 24 hours toward regeneration epidermis in add 2.5% activating agent after
Regeneration epidermal tissue structure chart；
Fig. 2 shows untreated epidermis and adds 0.5% activating agent, 1% activating agent and 2% activating agent to carry out in 24 hours
After process, the cartogram of the optical density under 570nm；
Fig. 3 shows untreated epidermis and 0.5% activating agent, 1% activating agent and 2% activating agent are carried out within 24 hours
After process in epidermis hydroxyproline content cartogram, wherein hydroxyproline levels unit be mg/L；
Fig. 4 shows untreated epidermis and 0.5% activating agent, 1% activating agent and 2% activating agent are carried out within 24 hours
After process in epidermis cell proliferation markers (Ki-67) quantity statistics figure；
Fig. 5 A show that untreated fish group after colour developing solution dyeing, enables proliferating cell nuclear antigen Ki-67 to manifest again
Raw epidermal tissue structure chart；Fig. 5 B showed within 24 hours, toward the regeneration epidermis regenerated after the activating agent that 0.5% is added in epidermis
Organization chart；Fig. 5 C show within 24 hours, and the regeneration epidermal tissue structure chart after 1% activating agent is added toward epidermis；
Fig. 5 D showed within 24 hours, toward the regeneration epidermal tissue structure chart regenerated after the activating agent that 2.5% is added in epidermis；
Fig. 6 A show that untreated fish group determines the regeneration epidermal tissue structure chart of the presence of Filaggrin after freezing；Fig. 6 B show
Within 24 hours, the regeneration epidermal tissue structure chart after 0.5% activating agent is added toward regeneration epidermis；Fig. 6 C show 24 hours it
It is interior, the regeneration epidermal tissue structure chart after 1% activating agent is added toward epidermis；Fig. 6 D showed within 24 hours, toward regeneration table
The regeneration epidermal tissue structure chart after 2.5% activating agent is added in skin.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than the embodiment of whole.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
The production procedure of undifferentiated Morus alba cell is preferably using the flow process recorded described in WO03/077881.
According to record of the current literature to plant undifferentiated cell, we can therefrom learn, neither one plant cell tool
The standby ability survived alone independently of other cells.
The undifferentiated cell of Morus alba can be extracted from whole plant, it is also possible to from some extracting sections of plant, for example
Leaf, stem, flower, petal, root, fruit, peel, shell, seed, flower pesticide, juice, thorn spine, bud, peel of stem, berry and it
Mixture.
Preferably, the undifferentiated cell of Morus alba is extracted from peel of stem, juice, bud and peel.
The undifferentiated cell of Morus alba can be extracted from the plant of tradition breeding, or be carried in the plant gone out from tissue culture
Take.
Tradition breeding refers to traditional training method, that is to say, that outdoor or in greenhouse, in soil, non-
The culture for carrying out on table or in the solution.
Tissue culture refers generally to those skilled in the art to be carried out by manual type from certain part of plant or plant
Extract.Different from tradition breeding, when Morus alba plant cell grows in culture vessel, by the pressure of physical and chemical condition
Power can filter out impurity, extract qualified plant cell, and the cell can the fresh-keeping whole year.
According to the present invention, it may be preferable to using the undifferentiated cell of the plant of tissue culture.Morus alba undifferentiated cell is carried
Taking preferably is carried out in the medium.
The method of any one that the undifferentiated cell of Morus alba can be recorded before use is extracted.It is such as tall by E.F.
Control and relate to Islington with P.D. and exist《Commercial laboratory handbook and catalogue》(Exegetics Ltd's 1984) " is carried out using tissue culture
Method described in the text of plant propagation ".
According to the present invention, the optimal medium that can be used is generally culture medium well-known to those skilled in the art.Such as,
B5 medium, MS culture medium, haler culture medium, WH culture medium etc..In E.F Georges, " plant of DJM Pu Tuoke and H.J Georges
Culture medium：Record in preparation and purposes " (Exegetics Ltd1987,1＆2 volume) text and be related to the complete of these culture medium
Explanation.
According to the present invention, it is desirable to prepare the undifferentiated culture plant cell of some Morus alba in MS culture medium.
According to the present invention, the particularity and correlative detail of composition will be illustrated by way of independent example.
The detection of the effectiveness in the present invention with regard to cosmetic composition will be illustrated in the following.
In the detection, following material has been used：
1. complete undifferentiated cell (preferably mix or be dispersed in suitable for the solvent of cosmetics) in Morus alba.
These Morus alba undifferentiated cells (preferably mix or be dispersed in suitable for the solvent of cosmetics) are using following
Mode is extracted and formed：
The first step：Morus alba cell is extracted, and is cultivated in tissue culture medium (TCM).
The extraction of Morus alba cell uses traditional method, then adopts and starts the step of continuously transplanting from stem.
This uses the B5 medium of the whole series, purchased from Sigma-Aldrich (Germany) company.Other culture medium are also
Feasible.
Second step：Morus alba cell is transplanted from the first step, and is cultivated in tissue culture medium (TCM), so that Morus alba cell
Bred.
The extraction process of Morus alba cell is (such as B5 medium) carried out in tissue culture medium (TCM) in the first step, is being contained
In the body medium of oxygen and carbon dioxide (rich carbonated air can make its density ratio reach 2 to 5%), include at one
In the cycle of 100 low light irradiations, intensity of illumination be less than 10lx (1 to 5lx), under environment with the humid air place 1 hour it is (wet
Degree is 75% or so), rich in carbon dioxide (density for making its carbon dioxide reaches 5%), temperature is kept for 30 DEG C.Its second step increases
The process of growing is referred to (to be made two in air respectively in low light irradiation and there was dampness in the air (humidity is 75% or so) rich in carbon dioxide
The content of carbonoxide is used more than 100000lx light irradiations in the environment of reaching 5%), and makes its humidity reach 45%.This time cultivate
Carry out in bright room, while can be by a lighttight dividing plate, the transformation being achieved from dark surrounds to bright light environments
Process.
3rd step：The extraction of Morus alba cell is carried out in tissue culture medium (TCM), for example, was carried out through one or many cleaning
Filter, especially it is noted that not destroying the membrane structure of Morus alba cell in operation.
4th step：Morus alba undifferentiated cell is scattered in carrier, such as disperseed in glycerol.
2. the mixture of peptide
According to the present invention, preparing peptide mixer needs to use following component：
2.1 carnosine
Carnosine is a kind of dipeptides (CAS numberings being made up of beta Alanine and histidine：305-84-0), its molecular weight is
226g, white powder.
2.2 rice peptide
Rice peptide be rice protein Jing after albumen enzyme effect, then it is specially treated obtained from protein hydrolysate,
For solution state, anti-corrosion agent (such as antimicrobial agent and antifungal agent containing the rice extract less than 1% and less than 1%
Agent).Rice peptide solution of the present invention is entered with the name for hydrolyzing Oryza sativa L. extraction protein (Thymophytane) by Vincience
Marketing sell about containing 0.3% rice peptide.
2.3Ala-Asp-Leu-Lys-Pro-Thr hexapeptide
Ala-Asp-Leu-Lys-Pro-Thr hexapeptides are alanine-Populus davidiana acid-LKP-Soviet Union's ammonia
Sour hexapeptide is a kind of active component of use in facial cream.This composition is studied and treatment magazine (2013) 19 in International Peptide:
In 217-224, by Anna Ao Lejienike et al. delivered entitled " mass spectrography is for alanine-Populus davidiana acid-leucine-
There is related description (can find in Springerlink.com in one text of the measure of Lys-Pro-threonine hexapeptide "
This article).This hexapeptide occurs as a solution, containing 0.5% to 6% hexapeptide (typically about 5%), is placed in by water and fourth
In the mixed liquor of glycol composition.
2.4 oligopeptide -1
Oligopeptide -1 is a kind of peptide containing less than 60 aminoacid.It is also considered as a kind of little albumen or epidermal growth factor
Son.Oligopeptide -1 is by BioOrganic Concepts companies (California, USA Santa Fe Spring this, postcode CA 90670)
Sold with entitled Dermatien EGF, the product is containing 25% (weight) ammonium sulfate and few less than 0.01% (weight)
The form of the aqueous solution of peptide -1.
The preparation (MP1) of peptide mixer is carried out in a container equipped with magnetic blender, adds 100ml'sEGF (oligopeptide -1 equivalent to 0.01g), mixes at normal temperatures, adds 100ml and contains 5% (weight
Amount) Ala-Asp-Leu-Lys-Pro-Thr hexapeptide solution, the carnosine of 100g is eventually adding, afterwards by 100ml's(rice peptide equivalent to 0.3g) is stirred.Compare oligopeptide -1, rice peptide and Ala-Asp-Leu-
The gross dry weight of Lys-Pro-Thr hexapeptides, the content of carnosine is much more in peptide mixer MP1.
Other peptide mixers from MP2 to MP10, are using in solution shapeEGF (solution form)
With Ala-Asp-Leu-Lys-Pro-Thr hexapeptides (solution form), carnosine (powder) and(solution
Form) prepare according to different proportion, such as table 1 below.
The ratio of each composition in the peptide mixer of table 1MP2 to MP10
| Mixture | MP2 | MP3 | MP4 | MP5 | MP6 | MP7 | MP8 | MP9 | MP10 |
| Oligopeptide -1 | 100ml | 100ml | 100ml | 100ml | 100ml | 100ml | 100ml | 100ml | 50ml |
| Ala-Asp-Leu-Lys-Pro-Thr hexapeptides | 100ml | 100ml | 50ml | 50ml | 25ml | 50ml | 50ml | 75ml | 20ml |
| Carnosine | 50g | 25g | 25g | 50g | 25g | 15g | 5g | 40g | 15g |
| Rice peptide | 100ml | 100ml | 100ml | 50ml | 50ml | 100ml | 25ml | 75ml | 40ml |
The mixing of peptide is preferably carried out in for the solvent of cosmetics, such as glycerol.
According to the present invention, cosmetic is applied to comprising one or more in cosmetic composition (aqueous solution) of the present invention
Excipient in product.This constituents may also contain one or more conventional cosmetic adjuvant simultaneously, can be fat-body, organic
Solvent, ion or non-ionic thickening agent, hydrophilic or lipotropy thickening agent, softening agent, wetting agent, opacifier, stabilizer, skin moistening
Agent, silicones, defoamer, spice, preservative, anionic surface agent, cation or nonionic and bi ion active agent,
Carrier, polymer, propellant, alkalization or acidulant, and other be usually used in cosmetic field and/or dermatological field into
Point.
Fat-body can be made up of a kind of oil or wax, or their mixing.Oil refers to liquid mixture at normal temperatures.
Wax refers to solid mixture at normal temperatures or the basic mixture into solid-state, and fusing point is generally greater than 35 degrees Celsius.
Oils ratio if any mineral oil (paraffin oil), vegetable oil (almond oil, macadamia nut oil, seed of black currant oil, simmondsia oil),
Artificial oil (such as hydrosqualene), alcohols, oxamides (Hamposyl L isopropyl ester), acids or lipid (for example contain
The benzoic acid alcohol of 12 to 15 carbon atoms, benzoic acid 2- Octyl Nitrites, cetylate, isopropyl propionate, triglyceride, citric acid/
Octanoic acid), silicone oil (cyclomethicone, polydimethylsiloxane) or fluorinated oil, poly alkylene glycol, trialkyl trimellitate
(such as tri trimellitate last of the ten Heavenly stems ester).
With regard to wax class, palm wax, Cera Flava, hydrogen-rich carburetion, Tissuemat E, polymethylene wax can be adopted.
With regard to organic solvent, can be using ethanol and low polyhydric alcohol.
Organic solvent can be selected in di-alcoholss and glycol ether, such as ethylene glycol, Polyethylene Glycol, butanediol
Or diethylene glycol.
Hydrophilic thickeners can select carboxy vinyl polymer, such asPolymer (Carbomer) and road are rich
The research and development of profit companyPolymer (acrylate copolymer/acrylic acid containing 10 to 30 carbon atoms)；Poly- third
Acrylamide；The copolymer of polymer and 2- acrylamido -2- methylpropanes, finally makes it reticulate structure, and/or makes wherein
With；The copolymer of 2- acrylamide -2- methyl propane sulfonic acids and 2-(Acryloyloxy)ethanol；Cellulose derivative, such as hydroxy ethyl fiber
Element；Polysaccharide, particularly natural gum, such as xanthan gum；And their mixture.
Lipotropy thickening agent can select synthetic polymer, such as polyalkyl acrylate (containing 10 to 30 carbon atoms) or change
Property clay, such as Strese Hofmann's hectorite. and its derivant.
Cosmetic composition in the present invention can be prepared according to the prior art of those skilled in the art.Into
The form divided can be that (H represents oil to single or compound emulsion, and E represents water：H/E, E/H, H/E/H or E/H/E), example
Can be hydrogel or the form in emulsion such as frost, breast or gel.Fill can also be carried out using the form of aerosol, may be used also
As one sees fit in the form of foam or spraying.
Cosmetic composition in the present invention is preferably presented with emulsion/suspension Water-In-Oil or oil-in-water form,
Can be with spirituosity, or not spirituosity, while good Morus alba cell dispersivity (particularly Morus alba) should be had.
Generally, emulsion should contain amphoteric emulsifier, anion emulsifier, cationic emulsifier and nonionic Emulsion
One of which in agent, can be used alone to be used in mixed way.Emulsifying agent should as needed realize the shape that emulsion needs
Formula (E/H or H/E) carries out appropriate selection.Other kinds of stabilizer, such as carrier, gel polymerisation can also be contained in emulsion
Thing or thickening agent.
As the surfactant of water/oil emulsion preparation, for example, can be using Arrcostab or Sorbitol
Ester, glycerin ether, saccharide ether；Organic silicon surfactant, such as Dimethicone Copolyol ratio is if any the mixed of cyclomethicone
Compound, dimethylsiloxane copolymer, alkyl dimethicone copolymerization ratio is if any dodecyl polymethyl siloxane copolymerization；Ten
Six alkyl dimethicone copolymerization and cetyl dimethicone copolymer, Hard Fat acid polyethylene glycol mixture and
Own ester admixture.Preferably select one or more common emulsifying agents from alkyl ester polyols group to be added thereto.
For alkyl ester polyols, for example, we can using emulsifying agent, nonionic emulsifier such as fatty acid ester and
Glyceride oxyalkylene (especially Polyethylene oxide)；Fatty acid ester and Isosorbide Dinitrate oxyalkylene；Oxyalkylene ester fatty acid (oxygen second
Alkene and/or expoxy propane), the mixture of such as PEG-100 stearates/glyceryl stearate；Alcohol ether fat (oxygen ethylene and/
Or expoxy propane), sugar ether such as sucrose stearate, mainly alkyl polyglucoside (APG) such as Decyl Polyglucoside and lauryl
Glucoside, the arachidonic mixture of cetearyl alcohol glycoside, such as alcohol, benzene alcohol mixture and Semen arachidis hypogaeae glucosides alcohol mixture.
In other emulsion stabilizers or suspension stabilizer, more can be poly- using M-phthalic acid polymer or thio-acid
The polymer of compound, especially phthalate/isophthalic sulphur/ethylene glycol, such as diethylene glycol/phthalate/isophthalic two
Polymer (the international cosmetic raw material name of formic acid/1,4- cyclohexanediols：Polyester-5).
For emulsion/suspension, its water can mutually include the nonionic porous dispersant prepared with known method.
For a further understanding of the present invention, it is illustrated with reference to specific embodiment.The present invention is in the following embodiments
Some samples are given, nonrestrictive, the cosmetic case composition for locally using.In these samples, including cooling it is undifferentiated
Morus alba cell (20 milliliters), glycerol (80 milliliters) and MP1 to MP10 mixture (20 milliliters), referred to generically hereinafter as activate
Agent (MCF).
If no special instructions, the used material of test or reagent are commercially available prod, can be bought by commercial channel
Obtain, it is the Episkin Companies of Lyons, France Alexandre Fleming streets 4 to rebuild human epidermal such as test tubeSkin model (F-69366), in the said firm's network address, describes and rebuilds the related details of epidermis.Special culture media is " the Modified MCDB of Ontario, Canada ID Labs company limiteies sale
153Medium " culture medium, catalogue numbering IS1141 (www.idlabs.com).MTT is purchased from Sigma-Aldrich companies,
Production code member M5655.MIB-1 antibody is purchased from Westbrook, ME (catalogue numbering 0505).If no special instructions, institute is tested
The method for using is method well known in the art.As MTT detection methods can be found in following network address：web.mnstate.edu/
Provost/mtt%20proliferation%20assay%20protocol.pdf
Embodiment 1：Cream
Formula：
MCF (* *) is the mixed liquor of undifferentiated fresh Morus alba cell (20ml) and the glycerol (80ml) for extracting, wherein also
The peptide mixer (MP1 to MP10) of 20ml is with the addition of, i.e. undifferentiated fresh Morus alba cell, glycerol and peptide mixer in MCF (* *)
The volume ratio of (MP1 to MP10) is 1:4:1.
The mastic granularity for preparing is very fine and smooth, and undifferentiated Morus alba cell is uniformly dispersed.Jing chemical characteristics are analyzed, and are not contained
Antibacterial, funguses, and ingredient stability is high.
The MCF of 1wt%, 2.5wt% can be separately added in addition, and the mastic of analogous components is obtained.Meanwhile, accordingly reduce water
Consumption, make toatl proportion reach 100%.
Embodiment 2：Cream
Formula：
MCF (* *) is the mixed liquor of undifferentiated fresh Morus alba cell (20ml) and the glycerol (80ml) for extracting, wherein also
The peptide mixer (MP1 to MP10) of 20ml is with the addition of, i.e. undifferentiated fresh Morus alba cell, glycerol and peptide mixer in MCF (* *)
The volume ratio of (MP1 to MP10) is 1:4:1.
The mastic granularity for preparing is very fine and smooth, and undifferentiated Morus alba cell is uniformly dispersed.Jing chemical characteristics are analyzed, and are not contained
Antibacterial, funguses, and ingredient stability is high.
The MCF of 1wt%, 2.5wt% can be separately added in addition, and the mastic of analogous components is obtained.Meanwhile, accordingly reduce water
Consumption, make toatl proportion reach 100%.
Embodiment 3：Cream
Water phase A：Deionized water is added in skin moistening product
Oil phase B：Emulsifying agent+emollient or Emollient materials+oil
C phases：Preservative, essence
D phases：Biologically active prod：(it is scattered in the solvent for being adapted to make cosmetics, spy containing the undifferentiated Morus alba cell for extracting
It is not glycerol) and peptide mixer (MP1 to MP10), in sticky suspension or gel shape.
Embodiment 4：Cosmetic water
Cosmetic water is pertaining only to water phase A, by the basis group such as deionized water, Propylene Glycol, preservative, essence and biologically active prod
Into.Wherein biologically active prod is containing the undifferentiated Morus alba cell (being scattered in the solvent for being adapted to make cosmetics) and peptide mixing for extracting
Thing (MP1 to MP10), in sticky suspension or gel shape.
Embodiment 5：Shampoo
Shampoo is pertaining only to water phase A, by deionized water, surfactant, foaming agent, thickening agent, essence and active component
Etc. basis composition.Wherein biologically active prod (is scattered in and is adapted to make the molten of cosmetics containing the undifferentiated Morus alba cell for extracting
In agent) and peptide mixer (MP1 to MP10), in sticky suspension or gel shape.
Embodiment 6：Gel
Add emulsifying agent class and thickening agent constituents in water phase A or oil phase B, hydrogel and oleogel can be made.
C phases：Essence, preservative
D phases：The undifferentiated Morus alba cell (being scattered in the solvent for being adapted to make cosmetics) for extracting and peptide mixer
(MP1 to MP10), in sticky suspension or gel shape.
Embodiment 7：Astringent
Astringent is pertaining only to water phase A, is made up of bases such as deionized water, essence, preservative and biologically active prods.Wherein
Biologically active prod is containing the undifferentiated Morus alba cell (being scattered in the solvent for being adapted to make cosmetics) and peptide mixer (MP1 for extracting
To MP10), in sticky suspension or gel shape.
Embodiment 8：Emulsion
Water phase A：Mainly it is made up of deionized water
Oil phase B：Oil+emulsifying agent+emollient
C phases：Preservative+skin moistening composition
D phases：Active component：Containing extract undifferentiated Morus alba cell (be scattered in be adapted to make cosmetics solvent in) and
Peptide mixer (MP1 to MP10), in sticky suspension or gel shape.
In above-mentioned experiment, phase A, phase B, phase C, phase D related to cream, gel or emulsion mix according to a conventional method, can root
The ratio between them is adjusted according to different purposes, male cosmetic is identical with its compound method.
The cosmetics used for specific region this kind of for cosmetic water, astringent and shampoo, ingredient is different, only
According to different purposes adjustment consumption and can be mixed in water phase, male cosmetic is identical with its compound method.
The ratio of undifferentiated Morus alba cell (complete) and peptide mixer (MP1 to MP10) is made up depending on specific nursing region
The property of product and the using effect expected.
It will be apparent that the invention is not limited in above-mentioned several experiments, also it can be prepared according to the nursing demand of specific region
The cosmetics of his quality, such as oils, cream, hair jelly, cosmetics (foundation cream, lipstick, cosmetic pencil, mascara or other can project eye
Portion's effect, for eyelashes colouring, increase or thicken the cosmetics of eyelashes, eye shadow).
Test example 1：The effectiveness of ingredient in detection invention
Before detection, a cosmetics substrate solution (being made up of second alcohol and water) need to be got ready, with this solution one is prepared respectively
Part " contrast solution " (control) and it is a according to present invention allotment, as constituent class " experimental solutions ".In " testing liquid "
The activator that middle addition is made up of the undifferentiated complete Morus alba cell and MP1 peptide mixers that are dispersed in glycerol is (wherein containing dry
The undifferentiated complete Morus alba cell and dry weight that weigh 2% are about 0.03% MP1 peptide mixers).
Before detection, human epidermal need to be rebuild using one piece of test tube, wherein Human Keratinocytes are had a common boundary in air/liquid
Use in faceSpecial culture media culture 14 days, the culture medium changed once per two days.Cultivated through 14 days, weight
Build epidermis and can be used for test experience.
A, toxicity detection
1st, test reagent：
Contrast solution is uniformly dispersed according to embodiment 1, without MCF (undifferentiated complete Morus alba cell, glycerol and MP1
Peptide mixer)
Testing liquid is uniformly dispersed according to experiment 1, adds MCF (undifferentiated complete Morus alba cell, glycerol and MP1 peptides
Mixture).
2nd, test method：
Reconstruction epidermis every square centimeter is respectively with 10 μ L, two kinds of test reagents and reconstruction dermal contact.After placing 24 hours,
Epidermis specimen is fixed with the formalin of 10% concentration.The epidermis of 4 μ m-thicks is vertically cut using hematoxylin-eosin staining method
Face is dyeed, and the staining conditions of different levels cell in epidermis are observed under an optical microscope.The reconstruction that two kinds were processed
Epidermis is contrasted with untreated reconstruction epidermis.
As a result show, the epidermis that the epidermis and testing liquid that contrast solution was processed was processed is tied with undressed epidermis
Structure is similar, so that it is determined that cell can survive in the epidermis for processing, and testing liquid does not have toxicity.
B, tissue slice detection and MTT detections
Need to use water-quality activating agent (hereinafter referred to as " activator ") in test.The activator is by being dispersed in not dividing in glycerol
(in above-mentioned activator, dry cell weight accounts for 2%, MP1 peptide dry weights and accounts for for the complete Morus alba cell changed and MP1 peptide mixers composition
0.03%).
According to the weight for rebuilding epidermis, respectively work is smeared with the proportion of 0.5wt%, 1wt%, 2.5wt% of epidermis weight
Agent is processed.Compareed with the epidermis without Treatment with activating agent.
Tissue slice is carried out to epidermis cell specimen, is dyeed using hematoxylin-eosin staining method, in optical microphotograph
The staining conditions of Microscopic observation epidermis cell.Epidermis and untreated reconstruction are rebuild by what Jing different content Treatment with activating agent was crossed
Epidermis is contrasted, and as a result sees Figure 1A to 1D.As a result show, place 24 hours or even after 48 hours, Jing different content activators
The reconstruction epidermis for processing is similar to undressed reconstruction epidermis.
Smear or do not smear after the reconstruction epidermis cell of activator places 24 hours under the conditions of 37 DEG C, rushed with culture medium
Wash, in then placing into other culture dish, add the MTT solution (MTT concentration is 5mg/mL) of 200 μ L.37 DEG C of cultures 4 are little
When.During this, the component of bluish violet crystallization first a ceremonial jade-ladle, used in libation (Formazan) of formation is inversely proportional to succinate dehydrogenase.Add 200 μ L
After dimethyl sulfoxide, each culture dish is cleared, and cell dissolves, bluish violet crystallization first a ceremonial jade-ladle, used in libation dissolving.After color becomes uniform, use and divide
Light photometer determines the cellular colours in each culture dish under 570nm wavelength.To the activated dose of epidermis for processing and without work
The epidermis of agent process carries out spectrophotometric analyses, as a result sees Fig. 2.
As a result show under 570nm wavelength, there is no optics between the reconstruction epidermis for processing and undressed epidermis
Difference in density.There is no the notable optical density (OD) difference on 570nm wavelength (mean difference is less than 1.5%).Show to live
Property agent is harmless to epidermis.
C, the detection to rubber polymer original albumen
After processing and undressed epidermis is placed 24 hours under the conditions of 37 DEG C, centrifugally operated is carried out, reclaim fine
Dimension blast cell, be put under the conditions of 4 DEG C, concentration for 0.5mL/L acetic acid solution in, collagen enzyme effect decline solution 24 hours.Jing
1000g centrifugal treating is crossed, collagen protein is precipitated out in NaCl solution.
The collagen protein thing being precipitated out is made suspension, then dialysis is extracted.Primary amine is determined with o-phthalaldehyde(OPA), with
Exclude the interference that they are caused.Equally, proline and hydroxyproline are determined under the chloro- 7- nitrobenzofurans effects of 4-.With
The NBD of hydroxyproline coupling is separated by HPLC, is determined (needing first to be calibrated).
HPLC analyses are carried out with the collagen protein sample of undressed skin factor of different to processing, Fig. 3 is as a result seen.
As a result show, only with after the Treatment with activating agent for accounting for epidermis proportion 0.5%, the Hydroxyproline content in epidermis will
Dramatically increase.Compared with undressed epidermis, the hydroxyl dried meat ammonia that the epidermis crossed with Treatment with activating agent is determined after placing 24 hours
Acid content is higher by 25%, Hydroxyproline content in the epidermis crossed with 2.5% Treatment with activating agent or even is higher by nearly 40%.Table
Bright, compared with undressed epidermis, the epidermis (2.5% according to epidermis weight is used) that Treatment with activating agent is crossed can promote to close
Into nearly as many as 40% collagen protein total amount.
D, the measure to mitotic index
After processing and undressed epidermis is placed 24 hours under the conditions of 37 DEG C, the formaldehyde with 10% concentration is water-soluble
Liquid fixes epidermis specimen.The epidermis being fixed in formaldehyde is put in paraffin embedding box, SABC is carried out after thinly slicing.Make
This chemical reaction is completed with MIB-1 antibody, Jing after Grape berry, is drawn most using PAP method
Termination fruit.After developer solution DAB (3.3- diaminobenzidines) dyeing, the Ki-67 nuclear antigen in cell section is brown, its growth
Expression is divided into following several stages：
G1 and S=cells are hidden and synthesis phase
The release stage of G2=cell compounds
M=mitosiss
Under 250 times of magnifieres, 10 regions are taken in per layer of section, have silk point by calculating corresponding nuclear antigen quantitative determination
Index is split, and the nuclear antigen quantity finally determined with untreated epidermis is contrasted, and as a result sees Fig. 4.
As a result show, after only being processed with the activating agent for accounting for epidermis proportion 0.5%, the quantity of cell marker will in epidermis
Dramatically increase.
Fig. 5 A, 5B, 5C, 5D be after colour developing solution dyeing, the untreated epidermis that shows from histology's angle and
The result of Ki-67 nuclear antigen in the epidermis of process.As a result it is displayed in the epidermis after the activator effect with 2.5% proportion, core
More than 20%, mitotic index grows beyond 27% to antigen levels increment.
E, the measure to silk polyprotein
Will after processing and undressed epidermis places 24 hours under the conditions of 37 DEG C, be transferred to -18 DEG C it is frozen.Will
The cell of freezing is put in paraffin embedding box, is then cut into slices, and carries out SABC detection.Examine under a microscope the poly- egg of detection silk
White number change, is as a result shown in Fig. 6 A, 6B, 6C, 6D.
As a result show, after frozen, the silk polyprotein quantity of granular layer is intensive and lasting in untreated epidermis；And pass through
In the granular layer of the epidermis of process, the wedge conformation density of silk polyprotein is relatively low, and the mark for illustrating epidermal differentiation is reduced.
Above-mentioned experiment shows that activator of the present invention is comprising undifferentiated complete Morus alba cell and containing carnosine, rice
Peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides, the peptide mixer of oligopeptide -1, are nontoxic cosmetic composition, undifferentiated complete
Whole Morus alba cell and containing between carnosine, rice peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides, the peptide mixer of oligopeptide -1
There is certain chemical action, use effect of cosmetics can be increased, the synthesis of collagen protein can be remarkably promoted, promote cell
Propagation, while slowing down epidermal differentiation.Adding activator of the present invention in cosmetic base liquid, can also to remarkably promote epidermis thin
Born of the same parents regenerate.
It should be pointed out that above-mentioned embodiment is not construed as limitation of the present invention, protection scope of the present invention should
It is defined by claim limited range.For those skilled in the art, without departing from the present invention's
In spirit and scope, some improvement can also be made, these improve and also should be regarded as protection scope of the present invention.
Claims (12)
1. a kind of cosmetic composition, includes at least：
A undifferentiated Morus alba cell that () extracts,
The peptide mixer of (b) containing carnosine, rice peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides and oligopeptide -1, and
C () is applied to cosmetic solvents.
2. cosmetic composition according to claim 1, it is characterised in that include：
The undifferentiated Morus alba cell for extracting of (a) 0.0005%-20% dry weights, and
(b) 0.0001%-10% dry weights containing carnosine, rice peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides and oligopeptide -1
Peptide mixer.
3. cosmetic composition according to claim 1, it is characterised in that include：
The undifferentiated Morus alba cell for extracting of (a) 0.001%-10% dry weights, and
(b) 0.0001%-5% dry weights containing carnosine, rice peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides and oligopeptide -1
Peptide mixer.
4. the cosmetic composition according to claim 1-3 any one, it is characterised in that described containing carnosine, rice
In the peptide mixer of peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides and oligopeptide -1, the weight of carnosine accounts for peptide mixer weight
1%-95%, preferably accounts for 5%-90%, more preferably accounts for 50%-85%；The weight of rice peptide accounts for peptide mixer weight 1%-50%,
It is preferred that accounting for 3%-40%, 4%-20% is more preferably accounted for；The weight of Ala-Asp-Leu-Lys-Pro-Thr hexapeptides accounts for peptide mixer weight
Amount 1%-50%, preferably accounts for 3%-40%, more preferably accounts for 4%-20%；The weight of oligopeptide -1 accounts for peptide mixer weight 1%-
50%, 3%-40% is preferably accounted for, more preferably account for 4%-20%.
5. the cosmetic composition according to claim 1-4 any one, it is characterised in that it is described extract do not divide
Change Morus alba cell dia it is average≤200 μm, preferably≤100 μm.
6. the cosmetic composition according to claim 1-5 any one, it is characterised in that it is described extract do not divide
Change Morus alba cell to operate in the incubator of carbon dioxide when extracting, while at the illumination of alternately 30 minutes to 6 hours
Reason and the non-illumination of 15 minutes to 2 hours are processed.
7. the cosmetic composition according to claim 1-6 any one, it is characterised in that it is described extract do not divide
Change Morus alba cell to mix with the solvent suitable for cosmetics.
8. the cosmetic composition according to claim 1-7 any one, it is characterised in that comprising suitable for cosmetics
Solvent, the solvent is glycerol and/or glycerol.
9. the cosmetic composition according to claim 1-8 any one, it is characterised in that described containing carnosine, rice
Rice peptide in the peptide mixer of peptide, Ala-Asp-Leu-Lys-Pro-Thr hexapeptides and oligopeptide -1 is the rice peptide of hydrolysis.
10. the cosmetic composition described in claim 1-9 any one has following at least one purposes：
Antioxidation and/or free radical resisting；
Defence ultraviolet, especially UVB；
Aging is prevented, can especially be limited or be slowed down face skin and relax；
Keep skin water profit；
Strengthen the oxidation resistance of skin；
Guarantee that endocrine is stablized；
Reduce coming off for keratinocyte；
Hyperproliferative skin cell, promotes and dramatically speeds up cell turnover；
Reduce the differentiation of epidermis cell；
To promote reepithelialization；
Promote and/or accelerate regenerating for collagen protein.
The purposes of 11. cosmetic compositions according to claim 10 any one, it is characterised in that for face,
The wide nursing of cheek, Fructus Mali pumilae flesh, canthus, eye socket, especially tear ditch, eye.
The purposes of 12. cosmetic compositions according to claim 10 any one, it is characterised in that can be made into cream
Frost, facial film, emulsion, astringent, solid or semi-solid cosmetics, various beauty pens, solid or semi-solid gel.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1654501A FR3051365B1 (en) | 2016-05-20 | 2016-05-20 | COSMETIC COMPOSITION BASED ON MORUS ALBA ENRICHED WITH PEPTIDES |
| FR1654501 | 2016-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106606454A true CN106606454A (en) | 2017-05-03 |
Family
ID=57113445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710019927.3A Pending CN106606454A (en) | 2016-05-20 | 2017-01-10 | Cosmetic using peptide-rich undifferentiated white mulberry cells as basic component |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN106606454A (en) |
| FR (1) | FR3051365B1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050265953A1 (en) * | 2002-03-20 | 2005-12-01 | Rachid Ennamany | Method of obtaining phytoalexins |
| CN103520081A (en) * | 2013-09-27 | 2014-01-22 | 无限极（中国）有限公司 | External skin care product capable of adjusting skin immunity and delaying skin aging |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2895261B1 (en) * | 2005-12-22 | 2009-06-05 | Vincience Sa | USE OF A RICE EXTRACT AS AN ACTIVE AGENT INDUCING THE SYNTHESIS OF SIRT PROTEINS IN SKIN CELLS |
-
2016
- 2016-05-20 FR FR1654501A patent/FR3051365B1/en active Active
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2017
- 2017-01-10 CN CN201710019927.3A patent/CN106606454A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050265953A1 (en) * | 2002-03-20 | 2005-12-01 | Rachid Ennamany | Method of obtaining phytoalexins |
| CN103520081A (en) * | 2013-09-27 | 2014-01-22 | 无限极（中国）有限公司 | External skin care product capable of adjusting skin immunity and delaying skin aging |
Non-Patent Citations (1)
| Title |
|---|
| ANNA OLEJNIK 等: "Determination of Hexapeptide ALA-ASP-LEU-LYS-PRO-THR by MALDI MS", 《INT J PEPT RES THER》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR3051365B1 (en) | 2018-05-04 |
| FR3051365A1 (en) | 2017-11-24 |
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