CN106581423A - Medicine for treating chronic constipation - Google Patents
Medicine for treating chronic constipation Download PDFInfo
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- CN106581423A CN106581423A CN201611272663.4A CN201611272663A CN106581423A CN 106581423 A CN106581423 A CN 106581423A CN 201611272663 A CN201611272663 A CN 201611272663A CN 106581423 A CN106581423 A CN 106581423A
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- constipation
- radix
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- 238000002360 preparation method Methods 0.000 claims description 19
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Abstract
The invention discloses a medicine for treating chronic constipation. The medicine is prepared from 15 g of radix angelicae sinensis, 12 g of radix astragali, 10 g of pericarpium citri reticulatae viride, 10 g of fructus aurantii, 6 g of rhubarb, 20 g of semen cassiae, 3 g of lotus leaves, 15 g of radix codonopsis, 15 g of stir-fried rhizoma atractylodis macrocephalae, 15 g of radix paeoniae alba, 10 g of rhizoma ligustici wallichi and 15 g of rhizoma polygonati. Radix angelicae sinensis can promote blood circulation and replenish blood and can be used for treating patients suffering from blood-deficiency constipation; radix codonopsis can replenish qi and nourish blood; radix astragali can replenish lung qi and tonify the spleen; the stir-fried rhizoma atractylodis macrocephalae can invigorate the spleen, replenish qi and soothe the mind and is used for treating patients suffering from qi-deficiency constipation; pericarpium citri reticulatae viride can relieve stagnant qi and disintegrate lumps, fructus aurantii can promote qi circulation and remove mites, and pericarpium citri reticulatae viride and fructus aurantii can promote peristalsis of small intestines of patients who suffer from gastroparesis resulting from diabetics when used together; rhubarb can eliminate turbidity by purgation and can also promote peristalsis of large intestines together with the lotus leaves; radix paeoniae alba and rhizoma ligustici wallichi can relieve pain, soothe the liver and promote blood circulation and are used for treating qi-depression constipation caused by depressed emotions; rhizoma polygonati can replenish qi and blood in the lung, the spleen and the kidney and has a beneficial effect on patients suffering from qi-deficiency constipation and blood-deficiency constipation; semen cassiae can moisten the intestines and relax the bowels.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, more particularly to a kind of medicine for treating chronic constipation.
Background technology
Chronic constipation is constipation repeatedly over a long time, and its morbidity can be not more transformed for a long time by acute constipation, also
Can be that the latter is common in the constipation caused by chronic disease from the beginning of as chronic constipation in morbidity.Constipation be constipation not
Logical, defecation time extends or is intended to just and a kind of involved and abstruse not smooth disease, and constipation can be temporary, may also be long-term, generally
Prolonged constipation we be also referred to as chronic constipation.The treatment of the method 1, protopathy of existing chronic constipation treatment, to finding
Protopathy, after clarifying a diagnosis, positive treatment is carried out using corresponding measure.As anal fissure can local anaesthesia expansion anus or row internal sphincter
Lateral incision art is treated；Then row is effected a radical cure or Palliative surgery colon tumor；Such as it is drug-induced constipation, then should withdraws this kind of medicine or use instead
He plant will not constipation medicine；Psychosiss, inner-sphere reorganization energy constipation induced should carry out corresponding treatment to eliminate protopathy as early as possible
Impact to function of intestinal canal etc..2nd, general treatment, is difficult to correct or has not temporarily found obvious Primary factors person for the moment in protopathy,
It is beneficial to most constipation patients using general measures.3rd, Drug therapy, the medicine that can be used for constipation therapy is a lot, but most uncomfortable
In patients with chronic constipation, also it is not suitable for long-term being suitable for.Currently, the phenomenon for abusing cathartic is more universal, cause it is few it is iatrogenic just
It is secret, clinically answer careful in selecting.4th, coloclysis, principal indication is preoperative INTESTINAL CLEANSING, fecal impaction, acute constipation.Warm physiology
Saline is more suitable, because it stimulates little to intestinal.And suds are too big because stimulating mucous membrane of colon, should avoid using.In addition, Jing
Often coloclysis are to produce dependency, it should be noted that.5th, surgical intervention, the indication of surgical intervention is mainly colon, rectum, anal canal device
Constipation caused by matter or feature pathological changes.6th, diet auxiliary, answers the food of appropriate polyphagia cellulose, can form early morning drink
The custom of one glass of boiled water or hydromel, also can before the meal give the hot beverage such as boiled water, Fructus Citri Limoniae juice, promote enterokinesia, stimulate defecation anti-
Penetrate；Suitably eat oils and fatss group food.7th, abdomen massage, from right to left repeated massage, defecation when encouraging old people to have awareness of defecation, it is to avoid
Causing constipation or enteral to form excrement block is detained Excreta.
In sum, existing chronic constipation Therapeutic Method effect on driving birds is not good, easily produces side effect, is unfavorable for that body is protected
It is strong.
The content of the invention
It is an object of the invention to provide a kind of treat medicine of chronic constipation and preparation method thereof, it is intended to solve existing
Chronic constipation Therapeutic Method effect on driving birds is not good, easily produces side effect, is unfavorable for the problem of health care of body.
The present invention is achieved in that a kind of medicine for treating chronic constipation, and the medicine of the treatment chronic constipation is by working as
Return 15g, Radix Astragali 12g, Pericarpium Citri Reticulatae Viride 10g, raw Fructus Aurantii 10g, Radix Et Rhizoma Rhei 6g, Semen Cassiae 20g, Folium Nelumbinis 3g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae (parched) 15g, white
Chinese herbaceous peony 15g, Rhizoma Chuanxiong 10g and Rhizoma Polygonati 15g are constituted.
Another object of the present invention is to a kind of preparation method of the medicine of described treatment chronic constipation is provided, it is described to control
The preparation method for treating the medicine of constipation is comprised the following steps：
Step one, takes each medical material of above-mentioned components by weight percent, plus the water of 9-12 times of medical material gross weight；
Step 2, soaks 1-1.5 hours, decocts 4 times, 1.5 hours every time, filters, merging filtrate, and filtrate reduced in volume is extremely
The extractum of relative density 1.11-1.26；
Step 3, adds ethanol to alcohol content to be 60%v/v-80%v/v, and cold preservation stands 50 hours, and ethanol is reclaimed in filtration
Concentrating under reduced pressure adds pharmaceutically acceptable carrier into extractum.
Another object of the present invention is to provide a kind of tablet of the medicine preparation by the treatment chronic constipation.
Another object of the present invention is to provide a kind of electuary of the medicine preparation by the treatment chronic constipation.
Another object of the present invention is to provide a kind of granule of the medicine preparation by the treatment chronic constipation.
Another object of the present invention is to provide a kind of capsule of the medicine preparation by the treatment chronic constipation.
Another object of the present invention is to provide a kind of ointment of the medicine preparation by the treatment chronic constipation.
The medicine of the treatment chronic constipation that the present invention is provided, Radix Angelicae Sinensis blood circulation promoting and enriching, for blood deficiency and constipation patient；Radix Codonopsis QI invigorating
Blood-nourishing, Radix Astragali tonifying the lung spleen invigorating, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI is calmed the nerves, for constipation due to deficiency of QI patient；Pericarpium Citri Reticulatae Viride dispelling the stagnated QI removes painful abdominal mass, raw Fructus Aurantii circulation of qi promoting
Except completely, two medicines are shared to be played the role of to promote small intestinal peristalsis to the gastroparesiss illness that diabeticss occur；Radix Et Rhizoma Rhei purging FU-organs let out turbid, lotus
Leaf phase same-action, promotes intestinal peristalsis；The Radix Paeoniae Alba and Rhizoma Chuanxiong can pain relieving again can soothing liver-QI promoting blood circulation, for the gas that feelings will does not freely occur
Strongly fragrant constipation；Rhizoma Polygonati tonifying the lung spleen kidney qi blood, has benefiting action to constipation due to deficiency of QI and blood deficiency and constipation；Semen Cassiae loosening bowel to relieve constipation.This
Bright using various pure Chinese medicines, therapeutic effect is all good, while having functions that health care of body.
Description of the drawings
Fig. 1 is the preparation method flow chart of the medicine that the embodiment of the present invention provides treatment chronic constipation.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that specific embodiment described herein is not used to only to explain the present invention
Limit the present invention.
The application principle of the present invention is explained in detail below in conjunction with the accompanying drawings.
The medicine for the treatment of chronic constipation provided in an embodiment of the present invention is by Radix Angelicae Sinensis 15g, Radix Astragali 12g, Pericarpium Citri Reticulatae Viride 10g, raw Fructus Aurantii
10g, Radix Et Rhizoma Rhei 6g, Semen Cassiae 20g, Folium Nelumbinis 3g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Radix Paeoniae Alba 15g, Rhizoma Chuanxiong 10g, Rhizoma Polygonati 15g.
As shown in figure 1, the preparation method of the medicine for the treatment of constipation provided in an embodiment of the present invention is comprised the following steps：
S101：Take each medical material of above-mentioned components by weight percent, plus the water of 9-12 times of medical material gross weight；
S102：Immersion 1-1.5 hours, decoct 4 times, 1.5 hours every time, filter, merging filtrate, and filtrate reduced in volume is to phase
Extractum to density 1.11-1.26；
S103：Add ethanol to alcohol content to be 60-80% (v/v), cold preservation stands 50 hours, filtration, reclaim ethanol decompression
Extractum is condensed into, pharmaceutically acceptable carrier is added.
The application effect of the present invention is explained in detail with reference to clinical trial.
1. physical data：
Choosing hospital outpatient carries out medical patients with chronic constipation 150 (excluding intestinal organic disease patient).Using
Random number method is divided into treatment group, 1 group of matched group, 2 groups of control, and each group patient is 50.
Wherein, treatment group, male 29, female 21；Age 35-75 year, year mean age (51.2 ± 3.26)；The course of disease
(10.28 ± 4.63) individual month, infrequent defecation time (4.56 ± 1.78) day.1 group is compareed, male 27, female 23；Age 36-72
Year, the mean age (49.8 ± 3.66) year；Individual month of the course of disease (9.75 ± 3.21), infrequent defecation time (4.32 ± 1.84) day.It is right
According to 2 groups, male 30, female 20；Age 34-71 year, year mean age (50.6 ± 4.17)；Individual month of the course of disease (9.84 ± 4.75),
Infrequent defecation time (5.15 ± 2.06) day.The aspects such as three groups of sex ratios, age, courses of disease are statistically analyzed, without significance
Meaning (P ＞ 0.05), with comparability.
2. Therapeutic Method：
Compare 1 group：Patient takes cisapride 10mg, and 3 times a day, before the meal half an hour take.
Compare 2 groups：Patient take comparative example preparation capsule, per 0.3g containing crude drug amount, 3 times a day, every time
2-4 grains, after meal half an hour take.
Treatment group：Patient take the embodiment of the present invention 1 preparation capsule, per 0.3g containing crude drug amount, 3 times a day, often
Secondary 2-4 grains, after meal half an hour take.
3 groups of patients continuously take medicine 2 months, and Outcome measure is carried out after 2 months.Patient is during medication.Forbid edible oil it is greasy,
Pungent, raw and cold food, it is ensured that therapeutic effect.During treating, the other treatment sick Chinese medicine and western medicine is not taken.
3. criterion of therapeutical effect：
Recovery from illness：Defecation is normal, and simultaneous phenomenon all disappears；
It is effective：Constipation is obviously improved, interval time and just matter be close to it is normal, or defecation slightly put down, interval time 72h with
Interior, simultaneous phenomenon is most of to disappear；
Effectively：Defecation time interval shortens 1 day, or the just dry and hard improvement of matter, and simultaneous phenomenon takes a turn for the better；
It is invalid：Constipation and simultaneous phenomenon are without improvement.
4. statistical method
With statistics software SPSS20.0 data are carried out with statistical analysis, enumeration data is checked using x2；Measurement data
Represented with mean ± standard deviation, carry out t inspections；P ＜ 0.05 represent that diversity is notable between two groups.
5. therapeutic outcome
Three groups, over the course for the treatment of without the case that comes off, complete clinical observation.Total effectses compare after 2 courses for the treatment of of treatment, control
Cure rate 72%, total effective rate 100% in treatment group, are superior to 1 or 2 group of control, and cure rate diversity is extremely notable.Compare 2 groups
Although cure rate is substantially not so good as treatment group better than 1 group of control, and diversity is extremely notable, shows arbitrarily to change prescription, it is impossible to
Reach the therapeutic effect of the present invention.
By the security inspection result for observing patient, treatment group does not occur relevant with medication bad anti-during treatment
Should, there is not larger fluctuation in hepatic and renal function indices and electrocardiogram before and after treatment, illustrate safety of medicine reliability of the present invention.
Presently preferred embodiments of the present invention is the foregoing is only, not to limit the present invention, all essences in the present invention
Any modification, equivalent and improvement made within god and principle etc., should be included within the scope of the present invention.
Claims (7)
1. a kind of medicine for treating chronic constipation, it is characterised in that the medicine of the treatment chronic constipation is by Radix Angelicae Sinensis 15g, the Radix Astragali
12g, Pericarpium Citri Reticulatae Viride 10g, raw Fructus Aurantii 10g, Radix Et Rhizoma Rhei 6g, Semen Cassiae 20g, Folium Nelumbinis 3g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Radix Paeoniae Alba 15g, Rhizoma Chuanxiong
10g and Rhizoma Polygonati 15g is constituted.
2. it is a kind of it is as claimed in claim 1 treatment chronic constipation medicine preparation method, it is characterised in that the treatment is just
The preparation method of secret medicine is comprised the following steps：
Step one, takes each medical material of above-mentioned components by weight percent, plus the water of 9-12 times of medical material gross weight；
Step 2, soaks 1-1.5 hours, decocts 4 times, 1.5 hours every time, filtration, merging filtrate, and filtrate reduced in volume is to relative
The extractum of density 1.11-1.26；
Step 3, adds ethanol to alcohol content to be 60%v/v-80%v/v, and cold preservation stands 50 hours, filtration, reclaims ethanol decompression
Extractum is condensed into, pharmaceutically acceptable carrier is added.
3. it is a kind of by described in claim 1 treat chronic constipation medicine preparation tablet.
4. it is a kind of by described in claim 1 treat chronic constipation medicine preparation electuary.
5. it is a kind of by described in claim 1 treat chronic constipation medicine preparation granule.
6. it is a kind of by described in claim 1 treat chronic constipation medicine preparation capsule.
7. it is a kind of by described in claim 1 treat chronic constipation medicine preparation ointment.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611272663.4A CN106581423A (en) | 2016-12-27 | 2016-12-27 | Medicine for treating chronic constipation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611272663.4A CN106581423A (en) | 2016-12-27 | 2016-12-27 | Medicine for treating chronic constipation |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181397A (en) * | 2007-11-28 | 2008-05-21 | 侯家祥 | Chinese medicine composition orally taken for curing constipation |
| CN104740041A (en) * | 2013-12-26 | 2015-07-01 | 盖春美 | Traditional Chinese medicine oral decoction for treating constipation |
| CN105796886A (en) * | 2016-04-29 | 2016-07-27 | 徐美英 | Pharmaceutical composition capable of treating chronic constipation |
-
2016
- 2016-12-27 CN CN201611272663.4A patent/CN106581423A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181397A (en) * | 2007-11-28 | 2008-05-21 | 侯家祥 | Chinese medicine composition orally taken for curing constipation |
| CN104740041A (en) * | 2013-12-26 | 2015-07-01 | 盖春美 | Traditional Chinese medicine oral decoction for treating constipation |
| CN105796886A (en) * | 2016-04-29 | 2016-07-27 | 徐美英 | Pharmaceutical composition capable of treating chronic constipation |
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Application publication date: 20170426 |