CN106581094A - Pharmaceutical composition for treating acne - Google Patents

Pharmaceutical composition for treating acne Download PDF

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CN106581094A
CN106581094A CN201611133217.5A CN201611133217A CN106581094A CN 106581094 A CN106581094 A CN 106581094A CN 201611133217 A CN201611133217 A CN 201611133217A CN 106581094 A CN106581094 A CN 106581094A
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pharmaceutical composition
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Jinan Haoyu Qingtian Medicine Technology Co ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/55—Liquid-liquid separation; Phase separation

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Abstract

The invention discloses a pharmaceutical composition for treating acne and a preparation method of the pharmaceutical composition. The pharmaceutical composition provided by the invention is prepared by proportioning the following medicinal raw materials: phyllagathis cavaleriei, plagiogyria distinctissima, ephedroxane, esculentoside A and esculentoside B, and the pharmaceutical composition can be prepared into various dosage forms in accordance with a conventional preparation process. The pharmaceutical composition is significant in curative effect on treating the acne.

Description

The pharmaceutical composition for the treatment of acne
Technical field
The invention belongs to technical field of Chinese medicines, more particularly to a kind of treat pharmaceutical composition of acne and preparation method thereof.
Background technology
Acne is commonly called as " acne ", is the chronic inflammatory disease of a kind of hair follicle, sebaceous gland, occurs mainly in the greasiness such as face and thoracic dorsal Area.There are self limiting, skin lesion multiform.Such as acne, pimple, pustule, tuberosity.Be often accompanied by seborrhea, after adolescence, mostly recovery from illness or Mitigate.In the past acne was considered as disease of sebaceous glands, and substantial damage includes hair follicle, sebaceous gland and epidermis.Belong to the traditional Chinese medical science " lung-wind syndrome Acne " category.Primary disease is more common in youth, and man is more than female, and infringement is apt to occur in the greasiness areas such as buccal, forehead, chin portion and nose buccal groove, its Secondary is chest, back and shoulder.From the beginning of for acne, having two kinds of Whiteheads and blackhead, cutin and sebum are included.Hoary hair's powder Thorn is also known as closed comedones, is color of the leather pimple, and syringe needle size, hair follicle opening is not obvious, is difficult to extrude fat bolt.Blackhead is also known as Open comedones, pimple central authorities are the pore that expands, and fat bolt blocks in follicular orifice, extruded with handss, it is seen that have top black and body Portion discharges in the translucent fat bolt of yellow, and because top is exposed to skin surface, sebum oxidation and dust affect, and form blackhead, so Referred to as blackhead.Except having, sebum is aoxidized and cutin comes off chip in acne, while the also hair comprising multiple carbonizations.The course of disease It is chronic, when it is light when weight, women Chang Yue it is premenstrual in periodicity increases.Primary disease has self limiting.After most patient's adolescence by It is decrescence light, so that disappearing.Primary disease is common in the youth of 17～18 years old, also there is early to 10～13 years old, late to adolescence or into People's morbidity.Man is more than female.Infringement is apt to occur in buccal, forehead, chin portion and nose buccal groove, is secondly back and upper breast.Socket of the eye perithelium Skin never involves.Motherland's medical science thinks many due to wind and heat in the lung meridian, or lung stomach accumulated heat, diseases caused by exogenous pathogenic factor evil poison, heat in blood stasis skin and cause.West Doctor thinks that primary disease is, because androgen secretion increases in adolescence body, to make smegma hyperfunction, and sebum forms acne, hair follicle And propionibacterium acness amount reproduction causes perifolliculitises in acne, inflammatory face rash or pustule are formed.In recent years, due to making up Product and urban air pollution, morbidity crowd's scope of acne also increased.
Bright and beautiful Rhizoma et radix valerianae：This product is Melastomataceae brocade Rhizoma et radix valerianae platymiscium brocade Rhizoma et radix valerianae Phyllagathis caualeriei The herb or root of (Levl.et van.) Guill. [Allomorphia caualerieiLevl. Et van.].Spring, summer adopt Grass is received, root whole year can adopt, clean, and chopping is dried.【Nature and flavor】Bitter in the mouth；It is pungent；It is cold in nature.【Indication】Clearing away heat and cooling blood；Profit It is wet.Main toxic-heat and blood stasis；Damp-heat vaginal discharge；Menoxenia；Metrorrhagia due to blood-heat；The hot hemorrhoidal bleeding of intestinal；Children's scrotum enlargement.【Former phytomorph】Grass This, high 10-15cm.Stem is upright or crawls, and raw section by section very nearly meat is close by long coarse wool, four prismatics, generally not branch.Leaf pair It is raw；The long 1.5-9cm of petiole, it is close by long coarse wool；Blade papery, wide avette, oval or circle, the wide anxious point of tip is to nearly circle Shape, base portion is heart-shaped, long 6-16cm, wide 4.5-14cm, and two sides green or sometimes back side aubergine, surface is thick by thin strigose shape length Hair, the back side only base goes out the long coarse wool that arteries and veins and lateral vein are flattened into；Base goes out arteries and veins 7-9, and surface normal pulse is whole, back side arteries and veins protuberance.Umbel, Basidixed, the long 4-17cm of total bennet is dilute several without hair by long coarse wool；Bract obovate or nearside lanceolar, by coarse wool, generally only 4 Piece, 1cm is about, or it is longer；Bennet is with calyx by pityrosporum；The prismatic of calyx funnel-form four, sliver is extensively avette；Petal pink is extremely Purple, top is slightly biased tiltedly, the anxious point of tip；Stamen 4, near isometric, flower pesticide base portion tool tubercle or obvious, connective is downward in short distance； Ovary is cup-shaped, tip tool hat.Capsule, tip hat 4 splits, and stretches out persistent calyx, and persistent calyx has 8 longitudinal ribs, carpopodium elongation, by pityrosporum.Flower Month phase 6-8, the fruiting period 7-9 month.Record in dictionary of medicinal plant.
Plagiogyria distinctissima ching.：For Plagiogyriaceae tumor foot Cyclosorus plant Plagiogyria distinctissima ching. Plagiogyria rankanensis Hayata[P.distinctissima Ching;P.adnata Bedd.] herb or rhizome.Summer, autumn harvesting, clean, and shine It is dry.【Nature and flavor】It is pungent；It is cool.【Return through】Enter bladder, lung, the Jing of liver three.【Indication】Deliver heat clearing away；Dispelling wind for relieving itching；Rash.Main flow row Sexuality emits；Measles；Skin pruritus；Metrorrhagia；Sprain.【Former phytomorph】The high 30-45cm of plant.Has the rhizome of upright or oblique ascension. Leafage gives birth to, two types；The long 14-18cm of nutrition petiole, base portion prismatic has 1-2 to pneumatophore, upwards slightly in prismatic or semicircle Shape；Blade long-narrow triangular mesh or ovum shape lanceolar, long 17-25cm, base portion width 8-11cm, a pinnation；Accessory pinna papery, 15-20 pair, alternate, long 4-6cm, wide 8-13mm, top and bottom are green, and acumen is micro-bend in falciform lanceolar, base portion upwards Asymmetric, upside is prolonged along rachis, and downside is circular, edge nearly full edge or with teeth；Vein pinniform, lateral vein is single or two forked.Spore The long 30-40cm of cotyledon petioles；Time pinniform of blade, long 14-22cm, wide 4-6cm；Accessory pinna 15-25 pair, it is in linear extremely to shrink, Long 5-7cm, wide 2-3mm；The usual y-bend of lateral vein, extends at limb 1/2.Sporangium is born in scun top, and accessory pinna is covered with when ripe Below.Record in dictionary of medicinal plant.
HPLC-ELSD（Phytolaccasaponin A）：CAS 65497-07-6, molecular formula C42H66O16, molecular weight 826.96.【Biological activity】Anti-inflammatory activity.【Ingredient origin】Radix Phytolaccae Phytolacca esculenta [Syn. Phytolacca acinosa]。
Esculentoside B（Phytolaccasaponin B）：CAS 66656-92-6, molecular formula C48H76O21, molecular weight 989.10.【Biological activity】Antiinflammatory, anti rheumatism action.【Ingredient origin】Radix Phytolaccae Phytolacca esculenta [Syn. Phytolacca acinosa]。
Herba Ephedrae dislikes alkali（Ephedroxane ）：CAS 16251-46-0, molecular formula C11H13NO2, molecular weight 191.23.【Medicine Reason is acted on】With antiinflammatory action.【Ingredient origin】Ephedraceae ephedra root.
3 crude drug chemical constitutions：
Esculentoside B（Phytolaccasaponin B）
HPLC-ELSD（Phytolaccasaponin A）Herba Ephedrae dislikes alkali（Ephedroxane ）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of pharmaceutical composition of effectively treatment acne and its Preparation method.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for making the crude drug of the pharmaceutical composition of the treatment acne be：
Bright and beautiful Rhizoma et radix valerianae 4780-4790 weight portions Plagiogyria distinctissima ching. 2650-2670 weight portions Herba Ephedrae dislikes alkali 30-36 weight portion Radix Phytolaccaes Saponin A 22-26 weight portion esculentoside B17-19 weight portions.
The pharmaceutical composition for the treatment of acne is preferably used in, is made up of the crude drug of following weight portion：
The weight portion Herba Ephedrae of 4785 weight portion Plagiogyria distinctissima ching. of bright and beautiful Rhizoma et radix valerianae 2660 dislikes the weight portion of 33 weight portion HPLC-ELSD of alkali 24 Esculentoside B18 weight portions.
A kind of pharmaceutical composition for treating acne, it is characterised in that pharmaceutical composition can adopt the conventional method of galenic pharmacy Prepare piece agent or capsule or drop pill.
A kind of pharmaceutical composition for treating acne, it is characterised in that the treatment that pharmaceutical composition is constituted with chemical drugs or Chinese medicine Acne medicine.
A kind of preparation method of the pharmaceutical composition for treating acne, it is characterised in that prepare as follows：
The composition and weight portion of crude drug be：Bright and beautiful Rhizoma et radix valerianae 4780-4790 weight portions Plagiogyria distinctissima ching. 2650-2670 weight portions fiber crops Huang dislikes alkali 30-36 weight portion HPLC-ELSD 22-26 weight portion esculentoside B17-19 weight portions；
Preparation method：
（1）Bright and beautiful Rhizoma et radix valerianae, Plagiogyria distinctissima ching., Herba Ephedrae are taken by crude drug proportioning and dislike alkali, HPLC-ELSD, esculentoside B, mixed, with weight Used as solvent, 33 DEG C of warm macerating are extracted the amount ethanol of percent concentration 33%, and extraction time is 11 times, and each extraction time is 24 hours, Every time solvent load is 27 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.09, filtration, medicinal liquid is first washed with water by S-8 macroporous adsorptive resins, then with weight percent concentration 22% Ethanol solution eluting S-8 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, and concentration is dry It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 11 times, carries every time The time is taken for 0.8 hour, each solvent load is 22 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.13 is concentrated into, is filtered, medicinal liquid is first washed with water by LSD632 macroporous adsorptive resins, then with again The amount ethanol solution eluting LSD632 macroporous adsorptive resins of percent concentration 46%, collect the ethanol elution of weight percent concentration 46% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for treating acne, it is characterised in that prepare as follows：
The composition and weight portion of crude drug be：The weight portion Herba Ephedrae of 4785 weight portion Plagiogyria distinctissima ching. of bright and beautiful Rhizoma et radix valerianae 2660 dislikes the weight of alkali 33 The weight portion esculentoside B18 weight portions of amount part HPLC-ELSD 24；
Preparation method：
（1）Bright and beautiful Rhizoma et radix valerianae, Plagiogyria distinctissima ching., Herba Ephedrae are taken by crude drug proportioning and dislike alkali, HPLC-ELSD, esculentoside B, mixed, with weight Used as solvent, 33 DEG C of warm macerating are extracted the amount ethanol of percent concentration 33%, and extraction time is 11 times, and each extraction time is 24 hours, Every time solvent load is 27 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.09, filtration, medicinal liquid is first washed with water by S-8 macroporous adsorptive resins, then with weight percent concentration 22% Ethanol solution eluting S-8 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, and concentration is dry It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 11 times, carries every time The time is taken for 0.8 hour, each solvent load is 22 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.13 is concentrated into, is filtered, medicinal liquid is first washed with water by LSD632 macroporous adsorptive resins, then with again The amount ethanol solution eluting LSD632 macroporous adsorptive resins of percent concentration 46%, collect the ethanol elution of weight percent concentration 46% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for treating acne, it is characterised in that pharmaceutical composition can adopt galenic pharmacy Conventional method prepare piece agent or capsule or drop pill.
A kind of preparation method of the pharmaceutical composition for treating acne, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine Composition Retinoids, Retin-A, Renova, Accutane.
Medicine composite for curing acne is evident in efficacy.
Specific embodiment
Embodiment 1：Pharmaceutical composition for the treatment of acne and preparation method thereof
Treatment acne pharmaceutical composition crude drug composition and weight portion be：Bright and beautiful Rhizoma et radix valerianae 4785g Plagiogyria distinctissima ching. 2660g Herba Ephedrae dislikes alkali 33g HPLC-ELSD 24g esculentoside B18g；
Preparation method：
（1）Bright and beautiful Rhizoma et radix valerianae, Plagiogyria distinctissima ching., Herba Ephedrae are taken by crude drug proportioning and dislike alkali, HPLC-ELSD, esculentoside B, mixed, with weight Used as solvent, 33 DEG C of warm macerating are extracted the amount ethanol of percent concentration 33%, and extraction time is 11 times, and each extraction time is 24 hours, Every time solvent load is 27 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.09, filtration, medicinal liquid is first washed with water by S-8 macroporous adsorptive resins, then with weight percent concentration 22% Ethanol solution eluting S-8 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, and concentration is dry It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 11 times, carries every time The time is taken for 0.8 hour, each solvent load is 22 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.13 is concentrated into, is filtered, medicinal liquid is first washed with water by LSD632 macroporous adsorptive resins, then with again The amount ethanol solution eluting LSD632 macroporous adsorptive resins of percent concentration 46%, collect the ethanol elution of weight percent concentration 46% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Pharmaceutical composition for the treatment of acne and preparation method thereof
Treatment acne pharmaceutical composition crude drug composition and weight portion be：Bright and beautiful Rhizoma et radix valerianae 4780g Plagiogyria distinctissima ching. 2670g Herba Ephedrae dislikes alkali 30g HPLC-ELSD 26g esculentoside B17g；
Preparation method：
（1）Bright and beautiful Rhizoma et radix valerianae, Plagiogyria distinctissima ching., Herba Ephedrae are taken by crude drug proportioning and dislike alkali, HPLC-ELSD, esculentoside B, mixed, with weight Used as solvent, 33 DEG C of warm macerating are extracted the amount ethanol of percent concentration 33%, and extraction time is 11 times, and each extraction time is 24 hours, Every time solvent load is 27 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.09, filtration, medicinal liquid is first washed with water by S-8 macroporous adsorptive resins, then with weight percent concentration 22% Ethanol solution eluting S-8 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, and concentration is dry It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 11 times, carries every time The time is taken for 0.8 hour, each solvent load is 22 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.13 is concentrated into, is filtered, medicinal liquid is first washed with water by LSD632 macroporous adsorptive resins, then with again The amount ethanol solution eluting LSD632 macroporous adsorptive resins of percent concentration 46%, collect the ethanol elution of weight percent concentration 46% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Pharmaceutical composition for the treatment of acne and preparation method thereof
Treatment acne pharmaceutical composition crude drug composition and weight portion be：Bright and beautiful Rhizoma et radix valerianae 4790g Plagiogyria distinctissima ching. 2650g Herba Ephedrae dislikes alkali 36g HPLC-ELSD 22g esculentoside B19g；
Preparation method：
（1）Bright and beautiful Rhizoma et radix valerianae, Plagiogyria distinctissima ching., Herba Ephedrae are taken by crude drug proportioning and dislike alkali, HPLC-ELSD, esculentoside B, mixed, with weight Used as solvent, 33 DEG C of warm macerating are extracted the amount ethanol of percent concentration 33%, and extraction time is 11 times, and each extraction time is 24 hours, Every time solvent load is 27 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.09, filtration, medicinal liquid is first washed with water by S-8 macroporous adsorptive resins, then with weight percent concentration 22% Ethanol solution eluting S-8 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, and concentration is dry It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 11 times, carries every time The time is taken for 0.8 hour, each solvent load is 22 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.13 is concentrated into, is filtered, medicinal liquid is first washed with water by LSD632 macroporous adsorptive resins, then with again The amount ethanol solution eluting LSD632 macroporous adsorptive resins of percent concentration 46%, collect the ethanol elution of weight percent concentration 46% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 124g of Example 1, adds starch 228g, mixes, and granulation is dried, plus Microcrystalline Cellulose 50g, Hard Fat Sour magnesium 1g, mixes, and is pressed into 800, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 63g of Example 2, adds starch 77g, mixes, and granulation is dried, granulate, adds appropriate magnesium stearate, Mix, encapsulated 400, obtain final product medicament composition capsule.
Embodiment 6：The preparation of drop pill
Weigh (80 DEG C) heating of polyethylene glycol 6000 210g water-baths and boil molten, add the g of 3 pharmaceutical composition of embodiment 12, fully stir Mix uniform, with liquid paraffin as coolant, put glass tubing（4*80cm）In, chilling temperature is -5 DEG C, and drip internal-and external diameter is 7.0/ 2.0 (mm/mm), drip is 2.5cm away from liquid level, and drop speed, as optimum condition, with cotton the cold of drop pill surface is blotted with per point 53 drops Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：The pharmaceutical composition for the treatment of acne
Treatment acne pharmaceutical composition crude drug composition and weight portion be：
Herba Ephedrae dislikes the weight portion esculentoside B45 weight portions of 30 weight portion HPLC-ELSD of alkali 20.
Embodiment 8：The pharmaceutical composition for the treatment of acne
Treatment acne pharmaceutical composition crude drug composition and weight portion be：
Herba Ephedrae dislikes the weight portion esculentoside B20 weight portions of 20 weight portion HPLC-ELSD of alkali 20.
Embodiment 9：The pharmaceutical composition for the treatment of acne
Treatment acne pharmaceutical composition crude drug composition and weight portion be：
Herba Ephedrae dislikes the weight portion esculentoside B35 weight portions of 40 weight portion HPLC-ELSD of alkali 20.
Experimental example 1：The experimental study for the treatment of acne
1 clinical data
1.1 diagnostic criteria
Promulgate with reference to State Administration of Traditional Chinese Medicine 1994《Chinese medical disease Standardization of diagnosis and curative effect》.Differentiation of symptoms and signs for classification of syndrome:(1) wind and heat in the lung meridian (15):Pimple color is red, or has pain of itching, red tongue, yellow and thin fur, floating and rapid pulse.(2) damp-heat accumulation (12):Erythra congestion and swelling pain, or There are pustule, halitosis, constipation, yellowish urine, red tongue, yellow and greasy fur, slippery and rapid pulse.(3) phlegm-damp condenses (13):Erythra forms cyst, or has Indigestion and loss of appetite, constipation, yellowish urine, light red tongue are fat, thin fur, rolling pulse.
1.1 case selection
Selection meets primary disease diagnostic criteria and Standards of Chinese Medical Syndrome Differentiation 40, wherein man 20, female 20；Age is minimum 15 years old, most Big 40 years old, the course of disease is most short 2 weeks, most long 7 years.
2 Therapeutic Method
2.1 oral medicinal herb
Using pharmaceutical composition（The pharmaceutical composition of embodiment 1）For main formula, with card taste is added:Damp-heat accumulation adds Herba Artemisiae Scopariae 20g, Rhizoma Atractylodis 10g；Phlegm-damp accumulation symptom adds Rhizoma Typhonii 40g (boiled water be decocted first more than 1h), and menoxenia adds Radix Angelicae Sinensis 25g, Rhizoma Chuanxiong 10g, Flos Carthami 10g.Top takes every time 350ml, and 3 times a day, 1 dose of day.7 doses is 1 course for the treatment of.
2.2 external treatment
Face does conventional cleaning and sterilizing, will have pus or the acne papule of sebum stasis of blood product thoroughly to be extruded clearly with finger squeezing and pressing method Liquid painting is penetrated after reason with metronidazole to put on the skin, pharmaceutical composition is then applied again（The pharmaceutical composition of embodiment 1）, washed with clear water after 1h Only, applied with " Cuo health kings " (Kuning Dianhong Pharmaceutical Co., Ltd.'s production) at ordinary times and put face on the skin, 3 times a day, disabled all faces and make up Product.2 times a week, 7 times is 1 course for the treatment of, and all cases disable any oral and medicine for external use, diet during treating for face cleaning treatment The thing of pungent savoury.
3 criterions of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Cure:Skin lesion disappears, or leaves slight pigmentation, in the recent period without recurrence；Effectively:Skin lesion is most of to disappear, and the state of an illness is basic It is stable；It is invalid:4 course for the treatment of local inflammations for the treatment of and cyst tuberosity, pigmentation is not improved.
3.2 therapeutic outcome
Healing 30, effective 9, invalid 1, total effective rate 97.5%.

Claims (8)

1. a kind of pharmaceutical composition for treating acne, it is characterised in that make the composition and weight of the crude drug of the pharmaceutical composition Part it is：
Bright and beautiful Rhizoma et radix valerianae 4780-4790 weight portions Plagiogyria distinctissima ching. 2650-2670 weight portions Herba Ephedrae dislikes alkali 30-36 weight portion Radix Phytolaccaes Saponin A 22-26 weight portion esculentoside B17-19 weight portions.
2. a kind of pharmaceutical composition for treating acne according to claim 1, it is characterised in that make the pharmaceutical composition The composition and weight portion of crude drug be：
The weight portion Herba Ephedrae of 4785 weight portion Plagiogyria distinctissima ching. of bright and beautiful Rhizoma et radix valerianae 2660 dislikes the weight portion of 33 weight portion HPLC-ELSD of alkali 24 Esculentoside B18 weight portions.
3. a kind of pharmaceutical composition for treating acne according to claim 1, it is characterised in that pharmaceutical composition can be adopted The conventional method of galenic pharmacy prepares piece agent or capsule or drop pill.
4. a kind of pharmaceutical composition for treating acne according to claim 1, it is characterised in that pharmaceutical composition and chemical drugs Or the Retinoids, Retin-A, Renova, Accutane of Chinese medicine composition.
5. a kind of preparation method of the pharmaceutical composition for treating acne, it is characterised in that prepare as follows：
The composition and weight portion of crude drug be：Bright and beautiful Rhizoma et radix valerianae 4780-4790 weight portions Plagiogyria distinctissima ching. 2650-2670 weight portions fiber crops Huang dislikes alkali 30-36 weight portion HPLC-ELSD 22-26 weight portion esculentoside B17-19 weight portions；
Preparation method：
（1）Bright and beautiful Rhizoma et radix valerianae, Plagiogyria distinctissima ching., Herba Ephedrae are taken by crude drug proportioning and dislike alkali, HPLC-ELSD, esculentoside B, mixed, with weight Used as solvent, 33 DEG C of warm macerating are extracted the amount ethanol of percent concentration 33%, and extraction time is 11 times, and each extraction time is 24 hours, Every time solvent load is 27 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.09, filtration, medicinal liquid is first washed with water by S-8 macroporous adsorptive resins, then with weight percent concentration 22% Ethanol solution eluting S-8 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, and concentration is dry It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 11 times, carries every time The time is taken for 0.8 hour, each solvent load is 22 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.13 is concentrated into, is filtered, medicinal liquid is first washed with water by LSD632 macroporous adsorptive resins, then with again The amount ethanol solution eluting LSD632 macroporous adsorptive resins of percent concentration 46%, collect the ethanol elution of weight percent concentration 46% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for treating acne according to claim 5, it is characterised in that by following step It is rapid to prepare：
The composition and weight portion of crude drug be：The weight portion Herba Ephedrae of 4785 weight portion Plagiogyria distinctissima ching. of bright and beautiful Rhizoma et radix valerianae 2660 dislikes the weight of alkali 33 The weight portion esculentoside B18 weight portions of amount part HPLC-ELSD 24；
Preparation method：
（1）Bright and beautiful Rhizoma et radix valerianae, Plagiogyria distinctissima ching., Herba Ephedrae are taken by crude drug proportioning and dislike alkali, HPLC-ELSD, esculentoside B, mixed, with weight Used as solvent, 33 DEG C of warm macerating are extracted the amount ethanol of percent concentration 33%, and extraction time is 11 times, and each extraction time is 24 hours, Every time solvent load is 27 times of crude drug gross weight, filters, and obtains medicinal residues A and extracting solution A, and extracting solution A reclaims ethanol, is concentrated into Relative density 1.09, filtration, medicinal liquid is first washed with water by S-8 macroporous adsorptive resins, then with weight percent concentration 22% Ethanol solution eluting S-8 macroporous adsorptive resins, collect the ethanol elution of weight percent concentration 22%, reclaim ethanol, and concentration is dry It is dry, obtain final product extract A；
（2）Take step（1）Medicinal residues A, with the ethanol of weight percent concentration 63% as solvent, heating and refluxing extraction 11 times, carries every time The time is taken for 0.8 hour, each solvent load is 22 times of medicinal residues A weight, filters, obtain medicinal residues B and extracting solution B, extracting solution B is returned Ethanol is received, relative density 1.13 is concentrated into, is filtered, medicinal liquid is first washed with water by LSD632 macroporous adsorptive resins, then with again The amount ethanol solution eluting LSD632 macroporous adsorptive resins of percent concentration 46%, collect the ethanol elution of weight percent concentration 46% Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for treating acne according to claim 5, it is characterised in that drug regimen Thing can adopt the conventional method of galenic pharmacy to prepare piece agent or capsule or drop pill.
8. a kind of preparation method of the pharmaceutical composition for treating acne according to claim 5, it is characterised in that drug regimen Thing and chemical drugs or Chinese medicine composition Retinoids, Retin-A, Renova, Accutane.
CN201611133217.5A 2016-12-10 2016-12-10 Pharmaceutical composition for treating acne Withdrawn CN106581094A (en)

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