CN106573031B - 双末端聚乙二醇化整合素-结合肽及其使用方法 - Google Patents

双末端聚乙二醇化整合素-结合肽及其使用方法 Download PDF

Info

Publication number
CN106573031B
CN106573031B CN201580032239.XA CN201580032239A CN106573031B CN 106573031 B CN106573031 B CN 106573031B CN 201580032239 A CN201580032239 A CN 201580032239A CN 106573031 B CN106573031 B CN 106573031B
Authority
CN
China
Prior art keywords
peg
peptide
conjugate
integrin
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580032239.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN106573031A (zh
Inventor
S·H·豪斯纳
J·L·萨克利夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CN106573031A publication Critical patent/CN106573031A/zh
Application granted granted Critical
Publication of CN106573031B publication Critical patent/CN106573031B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201580032239.XA 2014-04-15 2015-04-14 双末端聚乙二醇化整合素-结合肽及其使用方法 Active CN106573031B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461979997P 2014-04-15 2014-04-15
US61/979,997 2014-04-15
PCT/US2015/025700 WO2015160770A1 (en) 2014-04-15 2015-04-14 Bi-terminal pegylated integrin-binding peptides and methods of use thereof

Publications (2)

Publication Number Publication Date
CN106573031A CN106573031A (zh) 2017-04-19
CN106573031B true CN106573031B (zh) 2021-05-28

Family

ID=54324485

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580032239.XA Active CN106573031B (zh) 2014-04-15 2015-04-14 双末端聚乙二醇化整合素-结合肽及其使用方法

Country Status (8)

Country Link
US (3) US10919932B2 (https=)
EP (1) EP3131566B1 (https=)
JP (1) JP6789823B2 (https=)
CN (1) CN106573031B (https=)
AU (2) AU2015247833B2 (https=)
CA (1) CA2945945C (https=)
ES (1) ES2930029T3 (https=)
WO (1) WO2015160770A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6789823B2 (ja) 2014-04-15 2020-11-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 両末端ｐｅｇ化インテグリン結合性ペプチドおよびその使用方法
WO2016134164A1 (en) * 2015-02-18 2016-08-25 Memorial Sloan Kettering Cancer Center Methods of enhancing cerenkov luminescence using nanoparticles, and compositions related thereto
JP7174627B2 (ja) * 2015-10-23 2022-11-17 ウニフェルシタイト・トゥヴェンテ インテグリン結合ペプチド及びその使用
EP3468984A4 (en) * 2016-06-13 2020-03-11 The Regents of the University of California ALPHA (V) BETA (6) BINDING PEPTIDES AND METHODS OF USE THEREOF
BR112018076184A2 (pt) * 2016-06-16 2019-03-26 The University Of Liverpool composição sólida, composição farmacêutica ou veterinária na forma injetável, formulação intramuscularmente injetável, formulação subcutaneamente injetável, dispersão aquosa, dispersão oleosa, processos para preparar uma composição sólida, uma dispersão aquosa e uma dispersão oleosa, métodos para tratar e/ou prevenir uma infecção parasítica ou fúngica e para prevenir malária, e, kit para preparação de uma formulação líquida estéril de nanopartículas de atovaquona para injeção.
GB201613166D0 (en) * 2016-07-29 2016-09-14 Vectura Ltd Polymer
WO2018066692A1 (ja) * 2016-10-07 2018-04-12 国立大学法人東京工業大学 分岐型ヘテロ単分散ポリエチレングリコール、その製造方法、及びその結合体
SI3535397T1 (sl) * 2016-11-01 2022-04-29 Arrowhead Pharmaceuticals, Inc. Ligandi alfa-V beta-6 integrina in njihove uporabe
GB201706472D0 (en) * 2017-04-24 2017-06-07 Cancer Res Tech Ltd Tumour-targeting peptide variants
JP7445594B2 (ja) 2017-11-01 2024-03-07 アローヘッド ファーマシューティカルズ インコーポレイテッド インテグリンリガンドおよびその使用
WO2019154842A1 (en) * 2018-02-06 2019-08-15 Klinikum Rechts Der Isar Der Technischen Universität München Compound for intraoperative molecular bioimaging, method of making the same, use thereof in intraoperative molecular bioimaging and surgical method comprising intraoperative molecular bioimaging
EP3846858A4 (en) 2018-09-07 2022-10-19 The Regents of the University of California Alpha(v)beta(6) integrin-binding peptides and methods of use thereof
WO2020093055A2 (en) 2018-11-02 2020-05-07 Indi Molecular, Inc. Peptide libraries with non-canonical amino acids
US12589161B2 (en) * 2019-07-10 2026-03-31 The University Of Hong Kong PEGylated synthetic KL4 peptide, compositions and methods thereof
CN110522923A (zh) * 2019-09-19 2019-12-03 四川大学 果糖和rgd肽共修饰的双重靶向三阴性乳腺癌的脂质材料
CA3156667A1 (en) * 2019-10-02 2021-04-08 Sirnaomics, Inc. Oligonucleotides with nucleoside analogs
AU2020370362A1 (en) * 2019-10-25 2022-06-02 Children's Medical Center Corporation Computational design of alpha(v) beta (6) integrin binding proteins
WO2021226432A2 (en) * 2020-05-08 2021-11-11 The Regents Of The University Of California Methods of detecting and treating lung damage in respiratory-related viral infections
US20230277490A1 (en) * 2020-07-31 2023-09-07 Cedars-Sinai Medical Center Glutamine as an anticancer therapy in solid tumors
US20230405129A1 (en) * 2020-10-20 2023-12-21 The Boad Of Regents Of The University Of Taxas System Proinflammatory prodrugs
WO2022098745A1 (en) * 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
JP2023552383A (ja) * 2020-12-04 2023-12-15 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ペプチド受容体放射性核種療法
US12486502B2 (en) 2021-04-08 2025-12-02 Arrowhead Pharmaceuticals, Inc. RNAi agents for inhibiting expression of receptor for advanced glycation end-products, compositions thereof, and methods of use
WO2024263637A1 (en) 2023-06-20 2024-12-26 The Regents Of The University Of California Combination therapy with peptide receptor radionuclide and dna repair inhibitor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102985086A (zh) * 2010-03-29 2013-03-20 阿布拉科斯生物科学有限公司 增强药物递送和治疗剂有效性的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9108386D0 (en) * 1991-04-19 1991-06-05 Agricultural Genetics Co Modified plant viruses as vectors
US5429133A (en) 1992-12-18 1995-07-04 Neoprobe Corporation Radiation responsive laparoscopic instrument
US5446128A (en) 1993-06-18 1995-08-29 The Board Of Trustees Of The University Of Illinois Alpha-helix mimetics and methods relating thereto
AU3374795A (en) 1994-08-29 1996-03-22 Prizm Pharmaceuticals, Inc. Conjugates of vascular endothelial growth factor with targeted agents
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US6124128A (en) 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
GB0025414D0 (en) 2000-10-16 2000-11-29 Consejo Superior Investigacion Nanoparticles
WO2002068605A2 (en) 2001-02-26 2002-09-06 The Regents Of The University Of California Non-oligomerizing tandem fluorescent proteins
WO2002087497A2 (en) * 2001-04-26 2002-11-07 Board Of Regents, The University Of Texas System Therapeutic agent/ligand conjugate compositions, their methods of synthesis and use
US7469107B2 (en) 2003-07-23 2008-12-23 Lexmark International, Inc. Method for providing imaging substance for use in an imaging device via a virtual replenishment
WO2005116226A2 (en) 2004-05-24 2005-12-08 Midatech Ltd Nanoparticles comprising rna ligands
GB0520068D0 (en) * 2005-10-03 2005-11-09 Cancer Res Technology av peptide ligand
EP1935428A1 (en) * 2006-12-22 2008-06-25 Antisense Pharma GmbH Oligonucleotide-polymer conjugates
MX2010001363A (es) * 2007-08-09 2010-03-09 Syntonix Pharmaceuticals Inc Peptidos inmunomoduladores.
EP2455104B1 (en) 2010-11-19 2013-07-17 Universitätsklinikum Freiburg Bio-functionalized stimulus-responsive dissolvable PEG-hydrogels
CU23950B1 (es) * 2011-03-21 2013-10-29 Ct De Ingeniería Genética Y Biotecnología Péptidos cíclicos con actividad antineoplásica y antiangiogénica
US8895055B2 (en) 2011-12-21 2014-11-25 The Regents Of The University Of California Telodendrimer nanodiscs without apolipoprotein
JP6789823B2 (ja) 2014-04-15 2020-11-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 両末端ｐｅｇ化インテグリン結合性ペプチドおよびその使用方法
EP3468984A4 (en) * 2016-06-13 2020-03-11 The Regents of the University of California ALPHA (V) BETA (6) BINDING PEPTIDES AND METHODS OF USE THEREOF
EP3846858A4 (en) * 2018-09-07 2022-10-19 The Regents of the University of California Alpha(v)beta(6) integrin-binding peptides and methods of use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102985086A (zh) * 2010-03-29 2013-03-20 阿布拉科斯生物科学有限公司 增强药物递送和治疗剂有效性的方法

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Bioactive Hydrogels Made from Step-Growth Derived PEGPeptide Macromers;Jordan S. Miller;《Biomaterials.》;20100531;第31卷(第13期);3736-3743 *
Facile Formation of Dynamic Hydrogel Microspheres for Triggered Growth Factor Delivery;William J. King等;《Acta Biomater》;20110331;第7卷(第3期);975-985 *
Fluorescent Amphiphilic PEG-Peptide-PEG Triblock Conjugate Micelles for Cell Imaging;Tapas K. Paira等;《Macromol. Biosci》;20140331;第14卷(第7期);929-935 *
Integrin Structure, Activation, and Interactions;Iain D. Campbell等;《Cold Spring Harb Perspect Biol》;20110119;第3卷(第3期);1-14 *
PEG−Peptide Conjugates;Ian W. Hamley;《American Chemical Society》;20140401;第15卷(第5期);1543-1559 *
RGD肽在组织工程领域的应用;史嘉玮等;《中华实验外科杂志》;20050930;第22卷(第9期);1150-1152 *
Targeted in vivo Imaging of Integrin αvβ6 with an Improved Radiotracer and its Relevance in a Pancreatic Tumor Model;Sven H. Hausner等;《Cancer Res.》;20090731;第69卷(第14期);5843-5850 *

Also Published As

Publication number Publication date
AU2019232847B2 (en) 2020-08-27
EP3131566A4 (en) 2017-11-08
US11485758B2 (en) 2022-11-01
AU2015247833B2 (en) 2019-10-10
CA2945945C (en) 2023-10-03
CN106573031A (zh) 2017-04-19
AU2015247833A1 (en) 2016-11-10
EP3131566B1 (en) 2022-10-05
JP2017513859A (ja) 2017-06-01
WO2015160770A1 (en) 2015-10-22
ES2930029T3 (es) 2022-12-05
US10919932B2 (en) 2021-02-16
US20240101601A1 (en) 2024-03-28
AU2019232847A1 (en) 2019-10-10
US20210206804A1 (en) 2021-07-08
JP6789823B2 (ja) 2020-11-25
US20170174723A1 (en) 2017-06-22
EP3131566A1 (en) 2017-02-22
CA2945945A1 (en) 2015-10-22

Similar Documents

Publication Publication Date Title
CN106573031B (zh) 双末端聚乙二醇化整合素-结合肽及其使用方法
US12023391B2 (en) Alpha(v)beta(6) integrin-binding peptides and methods of use thereof
US11827687B2 (en) Synthetic somatostatin receptor ligands
US11591369B2 (en) Alpha(v)beta(6) integrin-binding peptides and methods of use thereof
EP4321526A1 (en) Peptide ligand targeting carbonic anhydrase ix, peptide construct comprising same, and uses thereof
HK1234666B (en) Bi-terminal pegylated integrin-binding peptides and methods of use thereof
HK1234666A1 (en) Bi-terminal pegylated integrin-binding peptides and methods of use thereof
EP4731270A1 (en) Combination therapy with peptide receptor radionuclide and dna repair inhibitor

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant