CN106551385A - A kind of functional composition with increase bone density and its application - Google Patents
A kind of functional composition with increase bone density and its application Download PDFInfo
- Publication number
- CN106551385A CN106551385A CN201510606746.1A CN201510606746A CN106551385A CN 106551385 A CN106551385 A CN 106551385A CN 201510606746 A CN201510606746 A CN 201510606746A CN 106551385 A CN106551385 A CN 106551385A
- Authority
- CN
- China
- Prior art keywords
- calcium
- milk
- functional composition
- product
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000037182 bone density Effects 0.000 title claims abstract description 37
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 235000013336 milk Nutrition 0.000 claims abstract description 79
- 239000008267 milk Substances 0.000 claims abstract description 79
- 210000004080 milk Anatomy 0.000 claims abstract description 79
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 46
- 239000011575 calcium Substances 0.000 claims abstract description 46
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 46
- 108010001441 Phosphopeptides Proteins 0.000 claims abstract description 28
- 229940071162 caseinate Drugs 0.000 claims abstract description 27
- 238000002360 preparation method Methods 0.000 claims abstract description 17
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 11
- 239000010452 phosphate Substances 0.000 claims abstract description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 9
- 229960005069 calcium Drugs 0.000 claims description 45
- 235000001465 calcium Nutrition 0.000 claims description 42
- 239000002994 raw material Substances 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 20
- 239000003381 stabilizer Substances 0.000 claims description 17
- 210000000481 breast Anatomy 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 210000000988 bone and bone Anatomy 0.000 claims description 10
- 229920002148 Gellan gum Polymers 0.000 claims description 9
- 239000000679 carrageenan Substances 0.000 claims description 9
- 235000010418 carrageenan Nutrition 0.000 claims description 9
- 229920001525 carrageenan Polymers 0.000 claims description 9
- 229940113118 carrageenan Drugs 0.000 claims description 9
- 239000000470 constituent Substances 0.000 claims description 9
- 239000000216 gellan gum Substances 0.000 claims description 9
- 235000010492 gellan gum Nutrition 0.000 claims description 9
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 9
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 8
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 7
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 4
- 239000001527 calcium lactate Substances 0.000 claims description 4
- 229960002401 calcium lactate Drugs 0.000 claims description 4
- 235000011086 calcium lactate Nutrition 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 4
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 4
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 4
- 239000005018 casein Substances 0.000 claims description 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 3
- 235000021240 caseins Nutrition 0.000 claims description 3
- 235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 3
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 229960003563 calcium carbonate Drugs 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 2
- 239000001354 calcium citrate Substances 0.000 claims description 2
- 229960004256 calcium citrate Drugs 0.000 claims description 2
- 239000004227 calcium gluconate Substances 0.000 claims description 2
- 229960004494 calcium gluconate Drugs 0.000 claims description 2
- 235000013927 calcium gluconate Nutrition 0.000 claims description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 2
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 claims description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- 229940005657 pyrophosphoric acid Drugs 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 235000013305 food Nutrition 0.000 abstract description 6
- 239000000796 flavoring agent Substances 0.000 abstract description 5
- 235000019634 flavors Nutrition 0.000 abstract description 5
- 235000019640 taste Nutrition 0.000 abstract description 5
- 239000000047 product Substances 0.000 description 59
- 235000020200 pasteurised milk Nutrition 0.000 description 21
- 230000000052 comparative effect Effects 0.000 description 16
- 239000000463 material Substances 0.000 description 16
- 238000000034 method Methods 0.000 description 11
- 238000013019 agitation Methods 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 238000012859 sterile filling Methods 0.000 description 6
- 238000007792 addition Methods 0.000 description 5
- 210000000689 upper leg Anatomy 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 238000007619 statistical method Methods 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 235000019658 bitter taste Nutrition 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 208000029725 Metabolic bone disease Diseases 0.000 description 2
- 102000014171 Milk Proteins Human genes 0.000 description 2
- 108010011756 Milk Proteins Proteins 0.000 description 2
- 206010049088 Osteopenia Diseases 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 235000021239 milk protein Nutrition 0.000 description 2
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 206010015719 Exsanguination Diseases 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 102000004407 Lactalbumin Human genes 0.000 description 1
- 108090000942 Lactalbumin Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000005571 anion exchange chromatography Methods 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000020186 condensed milk Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000020185 raw untreated milk Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000020255 yak milk Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a kind of with the functional composition for increasing bone density and its application.Phosphopeptide caseinate, phosphate and calcium preparation should be included with the functional composition for increasing bone density.Functional composition of the present invention can dramatically increase bone density, and be added in food, especially in milk product, not interfere with the taste and flavor of product, while also assures that the stability of product.
Description
Technical field
The present invention relates to food processing technology field.More particularly, to a kind of with the functional composition for increasing bone density and its application in milk product is prepared.
Background technology
Due to the aging of world population, there is osteoporosises and osteopenia, even if in prosperityCountryIt is also common metabolic osteopathy.It is a kind of skeletal diseases of general, is characterized in osteopenia, and the fine structure of osseous tissue is destroyed, and increases the fragility of bone, the dangerous increase of fracture.It can make the skeleton at any position in addition to head that fracture occurs.The intensity of known osseous tissue has 75%～85% relevant with bone density (BMD).Bone density, is an important symbol of bone mass.Aging with the age, the bone density of each skeleton in the whole body is in being gradually reduced trend.As can be seen here, it is necessary for mid-aged population to increase bone density.
From the point of view of existing market product variety, the product for increasing bone density is broadly divided into two classes：One class is calcic, and being reached by direct supplement calcium increases the purpose of bone density；It is another kind of to be free from calcium or not for the purpose of replenishing the calcium, but promote the absorption of calcium to increase bone density this purpose so as to reach by adjusting endocrine.101138383 A of CN disclose a kind of milk protein, the milk protein is particularly in skeleton sub-health population to various crowds certain effect, it is also have certain effect to the crowd of calcium absorption difference, however it is necessary that being prepared by technologies such as membrane filtration sterilization technology, membrance concentration technology, OMP activating technologies, anion chromatography purification technique, vacuum lyophilizations, complex process, high cost.103535415 A of CN disclose a kind of highland barley whole flour biscuits containing yak bone extract for strengthening bone density, and the functional raw material of the method is Os Bovis grunniens fine grinding powder, the full powder of Semen avenae nudae and yak milk powder, and product is only limitted to cookiess and cost of material is too high, are unfavorable for realizing.103039976 A of CN disclose a kind of capsule for increasing bone density, tablet, soft capsule, powder or oral liquid and preparation method thereof, comprising one or more in hyaluronic acid, Herba Epimedii, Rhizoma Drynariae, Radix Dipsaci, phosphopeptide caseinate in the dispensing of the method.Wherein hyaluronic acid, Herba Epimedii, Rhizoma Drynariae, Radix Dipsaci add in milk product does not have Regulations；The addition of phosphopeptide caseinate can cause product to have bitterness, and the product is only limitted to powder.
Phosphopeptide caseinate (CPP) is with bovine casein as raw material, by the polypeptide with biological activity obtained in biotechnology, can be used for various nutrition, in health food, absorption and utilization of the human body to the divalent mineral nutrient such as calcium, ferrum, zinc can be effectively facilitated.There are some calcium supplementing products that phosphopeptide caseinate is applied in combination with calcium at present, but to be made product that there is the function of increasing bone density, the addition of functional raw material just enough must be measured.Used as a kind of protein peptide, addition frequently can lead to greatly product bitterness to phosphopeptide caseinate.Additionally, milk product is referred to milk from cows and goats etc. as primary raw material, it is processed made by food.As a large amount of additions of the particularity in milk product field, phosphopeptide caseinate and calcium can affect the milk product especially mouthfeel of liquid milk product, local flavor and stability.
Based on the problems referred to above, it is necessary to which existing capability raw material is further studied, it is good to develop increase bone density effect, and suitable for the functional composition of milk product.
The content of the invention
First purpose of the present invention is to provide a kind of with the functional composition for increasing bone density, the functional composition can dramatically increase bone density, and be added in food, especially in milk product, the taste and flavor of product is not interfered with, while also assures that the stability of product.
Second object of the present invention is to provide the functional composition of above-mentioned increase bone density and is preparing with the application in the milk product for increasing bone substance density improving function.
Third object of the present invention is to provide a kind of liquid milk product, and the liquid milk product can dramatically increase bone density.
To reach above-mentioned purpose, the present invention adopts following technical proposals：
The present invention provides a kind of functional composition with increase bone density, and which includes phosphopeptide caseinate, phosphate and calcium preparation, wherein：Phosphopeptide caseinate:Phosphate radical:The mass ratio of calcium constituent is 1:1.5～5.0:0.5～2.5, i.e. phosphopeptide caseinate are calculated with pure phosphopeptide caseinate；Phosphate is calculated with total phosphate content；Calcium preparation is with the cubage of calcium constituent in calcium preparation.
In functional composition of the present invention, it is preferable that the phosphate includes one or more in sodium tripolyphosphate, sodium hexameta phosphate, sodium pyrophosphate, tertiary sodium phosphate, sodium dihydrogen phosphate, one hydrogen trisodium of disodium hydrogen phosphate and pyrophosphoric acid.It is highly preferred that the phosphate is selected from one or more in sodium tripolyphosphate, sodium hexameta phosphate and sodium pyrophosphate.
The calcium preparation includes one or more in milk calcium, Calcium Carbonate, calcium gluconate, calcium citrate, calcium lactate and calcium hydrogen phosphate.
In functional composition of the present invention, calcium preparation can generate soluble calcium when gastric acid is neutralized rises blood calcium by intestinal absorption.The present invention adds calcium preparation by external source, so as to improve supplementary calcium amount.Phosphopeptide caseinate is, with bovine casein as raw material, by the polypeptide with biological activity obtained in biotechnology, to effectively facilitate absorption and utilization of the human body to the divalent mineral nutrient such as calcium, ferrum, zinc.Through verification experimental verification, although both materials can increase bone density, there are much relations with their consumption, at present, the addition for increasing phosphopeptide caseinate can cause products taste and local flavor to change, while also affecting the stability of product, especially liquid form product.Present inventor is found surprisingly that phosphate adds the bitterness brought by phosphopeptide caseinates due to a large amount of in can eliminating product, while to dramatically increase bone density with phosphopeptide caseinate synergism, and the stability of product can be ensure that.
Further, the present invention is also claimed the above-mentioned functional composition with increase bone density and is preparing with the application in the milk product for increasing bone substance density improving function, the application particularly in liquid milk product.
In one embodiment of the invention, described is 1.5～5.5% with consumption of the functional composition of bone density in milk product is increased.
Further, in another specific embodiment of the present invention, the functional composition is applied to into liquid milk product, the liquid milk product includes the raw material of following weight parts：
Wherein, the milk refers to the raw milk for meeting food sanitation standard, including full-cream, defat or half defat, or by made by the other compositions reduction of milk powder, condensed milk, lactalbumin or milk goes back original product.
The stabilizer can be the stabilizer commonly used in dairy processing industry, including but not limited to, one or more in gellan gum, carrageenan and Microcrystalline Cellulose.The liquid milk of 100 weight portions is preferably based on, including：0.01～0.05 weight portion of carrageenan, 0.01～0.05 weight portion of gellan gum, 0.01～0.10 weight portion of Microcrystalline Cellulose.
Further, the present invention is also claimed the liquid milk product containing above-mentioned functions compositionss.If be improved to the species and taste of product according to market demand; using liquid milk product of the present invention as base material; one or more in addition essence, sweet substance, nutrient, fruit and vegetable juice, prepares various types of modulation breasts and milk beverage etc. and falls within invention which is intended to be protected.
In addition, milk product of the present invention, especially liquid milk product can be prepared by method well known in the prior art, in order to the present invention is discussed in detail, here is the present invention provide a kind of preparation method of liquid milk product：The method is included to milk cleaning；Then, pasteurize is carried out to the milk after purification, pasteurised milk is obtained；Take part pasteurised milk and be heated to 70～80 DEG C afterwards, stabilizer, functional composition are added, material under agitation, after 20～25min, add remaining pasteurised milk, then with water constant volume after, the liquid milk product is obtained through sterilizing, cooling.The condition of sterilizing is sterilizing 4～15 seconds under the conditions of 137～142 DEG C.
Beneficial effects of the present invention are as follows：
What the present invention was provided can dramatically increase bone density with the functional composition for increasing bone density, and be added in food, especially in milk product, not interfere with the taste and flavor of product, while also assures that stability of the product within the shelf-life.
Specific embodiment
In order to be illustrated more clearly that the present invention, with reference to preferred embodiment, the present invention is described further.It will be appreciated by those skilled in the art that specifically described content is illustrative and be not restrictive below, should not be limited the scope of the invention with this.
Embodiment 1
A kind of liquid milk product with increase bone density is prepared, which has following composition：
70.0 parts of milk；Stabilizer (carrageenan：0.01 part；Gellan gum：0.02 part；0.01 part of Microcrystalline Cellulose) 0.04 part；Functional composition (milk calcium：0.5 part；Phosphopeptide caseinate：1.0 part；Sodium tripolyphosphate：0.1 part)：1.6 part；Ingredient water：28.36 parts.Wherein, in milk calcium, the content of calcium constituent is 23%, and the purity of phosphopeptide caseinate is 15%.
The preparation method of the present invention, its step are as follows：
(1) raw material milk by temperature less than 8 DEG C, removes the mechanical admixture in raw material milk by net breast technique；
(2) by the raw material milk after net breast at 75 DEG C, the pasteurize of 30 seconds is carried out, and obtained pasteurised milk after pasteurize is cooled to into less than 8 DEG C；
(3) dispensing；Part pasteurised milk is heated to 70 DEG C, adds stabilizer and functional composition afterwards, under agitation material, material time 20min；
(4) add remaining pasteurised milk, then with water constant volume after, sterilized at 137 DEG C/4 seconds, and be cooled to less than 25 DEG C；
(5) sterile filling.
Embodiment 2
80.0 parts of milk；Stabilizer (carrageenan：0.03 part；Gellan gum：0.02 part；0.03 part of Microcrystalline Cellulose) 0.08 part；Functional composition (calcium lactate：0.3 part；Phosphopeptide caseinate：1.5 part；Sodium pyrophosphate：0.20 part)：2.0 part；Ingredient water：17.92 parts.Wherein, in calcium lactate, the content of calcium constituent is 98%, and the purity of phosphopeptide caseinate is 15%.
The preparation method of the present invention, its step are as follows：
(1) raw material milk by temperature less than 8 DEG C, removes the mechanical admixture in raw material milk by net breast technique；
(2) by the raw material milk after net breast at 85 DEG C, the pasteurize of 15 seconds is carried out, and obtained pasteurised milk after pasteurize is cooled to into less than 8 DEG C；
(3) dispensing；Part pasteurised milk is heated to 75 DEG C, adds stabilizer and functional composition afterwards, under agitation material, material time 25min；
(4) add remaining pasteurised milk, then with water constant volume after, sterilized at 139 DEG C/4 seconds, and be cooled to less than 25 DEG C；
(5) sterile filling.
Embodiment 3
85.0 parts of milk；Stabilizer (carrageenan：0.05 part；Gellan gum：0.05 part；0.10 part of Microcrystalline Cellulose) 0.20 part；Functional composition (milk calcium：2.8 part；Phosphopeptide caseinate：2.0 part；Sodium tripolyphosphate：0.5 part)：5.3 part；Ingredient water：9.50 part.Wherein, in milk calcium, the content of calcium constituent is 23%, and the purity of phosphopeptide caseinate is 15%.
The preparation method of the present invention, its step are as follows：
(1) raw material milk by temperature less than 8 DEG C, removes the mechanical admixture in raw material milk by net breast technique；
(2) by the raw material milk after net breast at 90 DEG C, the pasteurize of 10 seconds is carried out, and obtained pasteurised milk after pasteurize is cooled to into less than 8 DEG C；
(3) dispensing；Part pasteurised milk is heated to 80 DEG C, adds stabilizer and functional composition afterwards, under agitation material, material time 20min；
(4) add remaining pasteurised milk, then with water constant volume after, sterilized at 142 DEG C/4 seconds, and be cooled to less than 25 DEG C；
(5) sterile filling.
Comparative example 1
70.0 parts of milk；Stabilizer (carrageenan：0.01 part；Gellan gum：0.02 part；0.01 part of Microcrystalline Cellulose) 0.04 part；Milk calcium：0.5 part；Ingredient water：29.46 parts.Wherein, in milk calcium, the content of calcium constituent is 23%.
The preparation method of the present invention, its step are as follows：
(1) raw material milk by temperature less than 8 DEG C, removes the mechanical admixture in raw material milk by net breast technique；
(2) by the raw material milk after net breast at 75 DEG C, the pasteurize of 30 seconds is carried out, and obtained pasteurised milk after pasteurize is cooled to into less than 8 DEG C；
(3) dispensing；Part pasteurised milk is heated to 70 DEG C, adds stabilizer and milk calcium afterwards, under agitation material, material time 20min；
(4) add remaining pasteurised milk, then with water constant volume after, sterilized at 137 DEG C/4 seconds, and be cooled to less than 25 DEG C；
(5) sterile filling.
Comparative example 2
80.0 parts of milk；Stabilizer (carrageenan：0.03 part；Gellan gum：0.02 part) 0.05 part；Milk calcium：0.50 part；Phosphopeptide caseinate：0.1 part；Ingredient water：19.35 parts.Wherein, in milk calcium, the content of calcium constituent is 23%, and the purity of phosphopeptide caseinate is 15%.
The preparation method of the present invention, its step are as follows：
(1) raw material milk by temperature less than 8 DEG C, removes the mechanical admixture in raw material milk by net breast technique；
(2) by the raw material milk after net breast at 85 DEG C, the pasteurize of 15 seconds is carried out, and obtained pasteurised milk after pasteurize is cooled to into less than 8 DEG C；
(3) dispensing；Part pasteurised milk is heated to 75 DEG C, adds stabilizer, milk calcium and phosphopeptide caseinate afterwards, under agitation material, material time 25min；
(4) add remaining pasteurised milk, then with water constant volume after, sterilized at 139 DEG C/4 seconds, and be cooled to less than 25 DEG C；
(5) sterile filling.
Comparative example 3
85.0 parts of milk；Stabilizer (carrageenan：0.05 part；Gellan gum：0.05 part；0.10 part of Microcrystalline Cellulose) 0.20 part；Milk calcium：3.2 part；Phosphopeptide caseinate：2.1 part；Ingredient water：9.50 part.Wherein, in milk calcium, the content of calcium constituent is 23%, and the purity of phosphopeptide caseinate is 15%.
The preparation method of the present invention, its step are as follows：
(1) raw material milk by temperature less than 8 DEG C, removes the mechanical admixture in raw material milk by net breast technique；
(2) by the raw material milk after net breast at 90 DEG C, the pasteurize of 10 seconds is carried out, and obtained pasteurised milk after pasteurize is cooled to into less than 8 DEG C；
(3) dispensing；Part pasteurised milk is heated to 80 DEG C, adds stabilizer, milk calcium and phosphopeptide caseinate afterwards, under agitation material, material time 20min；
(4) add remaining pasteurised milk, then with water constant volume after, sterilized at 142 DEG C/4 seconds, and be cooled to less than 25 DEG C；
(5) sterile filling.
The study on the stability of six kinds of embodiments：
The stability of embodiment 1～3 and the milk product of comparative example 1～3 is enteredRow is investigatedExperiment, the outturn sample of each embodiment is stored at a temperature of room temperature (25 DEG C or so), 45 DEG C, the structural state of sample in the different Storage periods of observation, and determines rate of deposition (the rate of deposition assay method of stored sample under room temperature：In centrifuge tube, add 10mL samples, centrifuge speed 3000rpm/min, centrifugation time 10min, centrifugation after finishing, to weigh the percent that the weight (weight in wet base) of precipitate accounts for sample gross weight), to investigate the stability of each embodiment product.Experimental result is recorded inFollowing table 1。
Table 1Stability observing of the embodiment product in shelf life
FromTable 1Stability observing result can be seen that the sample of embodiment 1～3 and place one month under different temperature conditionss, observing samples structural state is normal, has good stability；After placing six months at room temperature, sample tissue state is normal, and every stability measurement index is within the acceptable range.Can determine that the product of embodiment 1～3 system stability in the shelf life of six months can receive, the shelf life requirement of six months can be met；And the sample of comparative example 1～3 occurs Severe fatty after certain hour is preserved and floats and precipitation occur.Illustrate that functional composition of the present invention does not interfere with the stability of product after being added in liquid milk product, it is ensured that product keeps good system stability in longer shelf life.
The mouthfeel evaluation comparison result of six kinds of embodiments, is shown inTable 2：
Table 2：The mouthfeel evaluation of product in embodiment
FromTable 2As can be seen that the product of embodiment 1～3 is liked by consumers in general deeply, the index of each side all obtains higher evaluation；And the evaluation of the product acquisition of comparative example 1～3 is then relatively low.
Product increases the investigation of bone density effect
By embodiment 1, embodiment 2, embodiment 3, comparative example 1, the product that comparative example 2 and comparative example 3 provide is used as test sample, this test chooses 60 kunming mices as subjects, it is divided into six groups immediately, per group is 10, respectively to embodiment 1, embodiment 2, embodiment 3, comparative example 1, the product that comparative example 2 and comparative example 3 provide carries out gavage, Jing pentobarbital sodiums anesthesia after 6 weeks, ventral aorta sacrificed by exsanguination mice, measure its bone density and femur weight in wet base, and statistical analysis are carried out to detection data, the results are shown in Table 3～table 5.
Table 3The bone density and femur weight in wet base of each embodiment
| Animal number of elements | Bone density (g/cm2) | Femur weight in wet base (g) | |
| Embodiment 1 | 10 | 0.25 | 2.02 |
| Embodiment 2 | 10 | 0.27 | 1.99 |
| Embodiment 3 | 10 | 0.26 | 2.09 |
| Comparative example 1 | 10 | 0.17 | 1.72 |
| Comparative example 2 | 10 | 0.16 | 1.69 |
| Comparative example 3 | 10 | 0.15 | 1.65 |
Table 4The results of statistical analysis of Bone mineral density data
Paired samples is checked
Table 5The results of statistical analysis of femur weight in wet base detection data
Paired samples is checked
ByTable 3~Table 5Understand, on bone density and femur weight in wet base is increased, in the present invention, the product of embodiment 1～3 shows that with the statistical analysis of the product of comparative example 1～3 the P values (Sig) of the two are respectively 0.01 and 0.018, respectively less than 0.05, illustrate statistically there is significant difference.Therefore, relative contrast's embodiment 1～3, the product of embodiment 1～3 have the function of significantly increasing bone density.
Obviously; the above embodiment of the present invention is only intended to clearly illustrate example of the present invention; and it is not the restriction to embodiments of the present invention; for those of ordinary skill in the field; can also make other changes in different forms on the basis of the above description; here all of embodiment cannot be exhaustive, it is every belong to technical scheme it is extended obvious change or change still in protection scope of the present invention row.
Claims (9)
1. it is a kind of with the functional composition for increasing bone density, it is characterised in that it includes casein phosphorus
Sour peptide, phosphate and calcium preparation, wherein：Phosphopeptide caseinate:Phosphate radical:The mass ratio of calcium constituent is 1:1.5～
5.0:0.5～2.5.
2. functional composition according to claim 1, it is characterised in that the phosphate includes
Sodium tripolyphosphate, sodium hexameta phosphate, sodium pyrophosphate, tertiary sodium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate
With one or more in one hydrogen trisodium of pyrophosphoric acid.
3. functional composition according to claim 1, it is characterised in that the calcium preparation includes breast
One or more in calcium, Calcium Carbonate, calcium gluconate, calcium citrate, calcium lactate and calcium hydrogen phosphate.
4. the functional composition with increase bone density described in claim 1-3 any claim existing
Prepare with the application in the milk product for increasing bone substance density improving function.
5. application according to claim 4, it is characterised in that the functional composition is in breast system
Consumption in product is 1.5～5.5%.
6. the application according to claim 4 or 5, it is characterised in that the milk product is liquid milk
Product.
7. application according to claim 6, it is characterised in that the liquid milk product includes following
The raw material of weight portion：
Milk：70.0～90.0 parts
Stabilizer：0.03～0.20 part
Functional composition：1.50～5.50 parts
Excess water is to 100 parts.
8. application according to claim 6, it is characterised in that the stabilizer include gellan gum,
One or more in carrageenan and Microcrystalline Cellulose.
9. it is a kind of with the liquid milk product for increasing bone substance density improving function, it is characterised in that it is according to right
The application described in 6-8 any claims is required, the functional composition is added to into liquid milk product
In it is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510606746.1A CN106551385A (en) | 2015-09-18 | 2015-09-18 | A kind of functional composition with increase bone density and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510606746.1A CN106551385A (en) | 2015-09-18 | 2015-09-18 | A kind of functional composition with increase bone density and its application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106551385A true CN106551385A (en) | 2017-04-05 |
Family
ID=58414999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510606746.1A Pending CN106551385A (en) | 2015-09-18 | 2015-09-18 | A kind of functional composition with increase bone density and its application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106551385A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109699889A (en) * | 2017-10-26 | 2019-05-03 | 内蒙古伊利实业集团股份有限公司 | A kind of composition and products thereof improving osteoporosis, preparation and application |
| CN109769947A (en) * | 2017-11-15 | 2019-05-21 | 内蒙古伊利实业集团股份有限公司 | A kind of improvement bone health functional composition and products thereof and application |
| CN111068044A (en) * | 2020-01-06 | 2020-04-28 | 新疆华圣元医药科技有限公司 | Pharmaceutical composition with bone mineral density increasing effect and preparation thereof |
-
2015
- 2015-09-18 CN CN201510606746.1A patent/CN106551385A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109699889A (en) * | 2017-10-26 | 2019-05-03 | 内蒙古伊利实业集团股份有限公司 | A kind of composition and products thereof improving osteoporosis, preparation and application |
| CN109769947A (en) * | 2017-11-15 | 2019-05-21 | 内蒙古伊利实业集团股份有限公司 | A kind of improvement bone health functional composition and products thereof and application |
| CN111068044A (en) * | 2020-01-06 | 2020-04-28 | 新疆华圣元医药科技有限公司 | Pharmaceutical composition with bone mineral density increasing effect and preparation thereof |
| CN111068044B (en) * | 2020-01-06 | 2022-03-08 | 新疆华圣元医药科技有限公司 | Pharmaceutical composition with bone mineral density increasing effect and preparation thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101543245B (en) | Neutral liquid high calcium milk and preparation method thereof | |
| CN101322513A (en) | Liquid state dairy food and producing method thereof | |
| JP5373227B1 (en) | Method for producing nutritional composition | |
| CN103891895A (en) | Liquid dairy product containing earthworm protein and preparation method of liquid dairy product | |
| CN104855517A (en) | Maca health milk and preparation method thereof | |
| CN106255421A (en) | The manufacture method of Bulbus Allii fermentation composition and Bulbus Allii fermentation composition | |
| EP3389393A1 (en) | Heat sterilized high protein compositions comprising whey protein and at least one component selected from (i) a saccharide, (ii) a phosphate and (iii) a citrate | |
| CN106465749A (en) | A kind of fermentation milk containing egg yolk liquid and preparation method thereof | |
| CN106509138A (en) | Goat milk powder suitable for middle-aged people and old people and preparation method of goat milk powder | |
| CN103478260B (en) | A kind of liquid milk and preparation method thereof | |
| CN106551385A (en) | A kind of functional composition with increase bone density and its application | |
| CN107212378A (en) | A kind of function composition with regulation enteron aisle and its application | |
| CN102422889A (en) | Liquid state dairy product for health care and production method thereof | |
| CN105558035A (en) | Liquid milk product for protecting angiocarpy, maintaining beauty and keeping young | |
| KR101855740B1 (en) | Mixed composition of vitamin and mineral for awakening and enhancing concentration and uses thereof | |
| CN101755922B (en) | Acid liquid milk product added with salt algae powder and preparation method thereof | |
| CN101589741B (en) | Liquid dairy product containing medlar granules and production method thereof | |
| CN106615137A (en) | Protein peptide solid beverage and preparation method thereof | |
| CN106472856A (en) | Animal protein-free feedstuff for SPF kind duck brood time and preparation method thereof | |
| CN105941625A (en) | Fermented milk-containing Chinese yam beverage and preparation method thereof | |
| CN102138585A (en) | Resveratrol-added dairy product and preparation method thereof | |
| RU2603275C1 (en) | Method for production of curd dessert | |
| CN114938850B (en) | Giant salamander peptide nutritional composition for promoting growth of children | |
| CN107105688A (en) | Phosphorus absorbs suppression composition | |
| CN109769947A (en) | A kind of improvement bone health functional composition and products thereof and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170405 |