CN106539996A - A kind of Western medicine combination for treating febris acuta and preparation method thereof - Google Patents
A kind of Western medicine combination for treating febris acuta and preparation method thereof Download PDFInfo
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- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of Western medicine for treating febris acuta is combined, it is made up of according to weight portion following raw material:25 parts of auxiliary material, 5 10 parts of paracetamol, 0.5 3 parts of cellulose, 0.1 1.5 parts of vitamin, 6 parts of amino acid/11,5 10 parts of tylenol, 26 parts of brufen, 49 parts of smalt leaf sap, 36 parts of 15 24 parts of ethanol solution, 1.5 4 parts of penicillin and the bupleurum particles that volume fraction is 50 60%.The present invention also disclosed the preparation method of the Western medicine combination.Raw material sources of the present invention are extensive, preparation process is simple, it is adaptable to large-scale industrial production;In the present invention, the component such as smalt leaf sap, bupleurum particles, tylenol, brufen plays synergy, and formula is reasonable, easy to use, treatment rate and it is efficient be superior to existing product, no toxic and side effect, using effect are good.
Description
Technical field
The present invention relates to a kind of conventional Western medicine combination, specifically a kind of Western medicine combination for treating febris acuta.
Background technology
When temperature is jumpy, many people will it is weak because of passive protective physical fitness, do not increase or decrease in time
The reasons such as clothing are sick, wherein and to catch a cold, cough and generate heat most commonly seen.Heating, also known as fever, be heating be due to heating
Activator acts on body, and then causes the generation of inner-growth model (EP) to be incorporated to brain and act on heat-regulating centers, more further
The release of central mediators of causing to generate heat causes the change of set point then, and the modulability body temperature rising for finally causing is (more than 0.5
DEG C), heating is simultaneously often accompanied by the non-specific symptoms such as dizzy dizziness, headache, weak anorexia, the reason for cause heating a lot,
Most commonly infection (including various bacterium infections, virus infection, mycoplasma infection etc.), (the i.e. glue next to that CTD
Former disease), malignant tumour etc..Heating can be divided into febris acuta (hot journey be less than 2 weeks), long-term according to hot journey heat type and clinical characters
Heating (hot journey was more than 2 weeks and multiple body temperature is more than 38 DEG C) and heating (periodic fever) repeatedly.Febris acuta is that people are most common
A kind of heating, current people are to treat febris acuta using antipyretic, but the therapeutic effect of existing antipyretic is bad,
Treatment time is long, and not thoroughly, this just brings pain for patient for treatment.
The content of the invention
It is an object of the invention to provide a kind of Western medicine for treating febris acuta is combined, to solve above-mentioned background technology
The problem of middle proposition.
For achieving the above object, the present invention provides following technical scheme:
A kind of Western medicine for treating febris acuta is combined, and is made up of according to weight portion following raw material:It is auxiliary material 2-5 parts, right
Paracetamol 5-10 parts, cellulose 0.5-3 parts, vitamin 0.1-1.5 parts, -6 parts of amino acid/11, tylenol 5-10 parts, Bu Luo
Fragrant 2-6 parts, smalt leaf sap 4-9 parts, ethanol solution 15-24 parts that volume fraction is 50-60%, penicillin 1.5-4 parts and bavin
Hu particle 3-6 parts, smalt leaf sap adopt the mass fraction that folium isatidis is immersed in 5-8 times for 70% ethanol in 2-4 time, every time
Immersion 4-5 hours, merge soak and filter, and collect filtrate and obtain.
As further scheme of the invention:Auxiliary material using starch, lactose, dextrin, xylitol, superfine silica gel powder, sucrose and
One or several mixture of glucose, cellulose adopt microcrystalline cellulose or carboxymethylcellulose calcium.
As further scheme of the invention:Vitamin is using vitamin A, vitamin B1, vitamin C and vitamin K
One or several mixture, amino acid adopt one or several of serine, lysine, glutamic acid and aspartic acid
Mixture.
The preparation method that the Western medicine for treating febris acuta is combined, comprises the following steps that:
Tylenol, brufen and bupleurum particles are mixed and are crushed using pulverizer, after crushing by step one
Product crosses 30-50 mesh sieve, obtains the first mixture, gives over to standby;
Step 2, paracetamol, cellulose, vitamin, amino acid and penicillin are put in ethanol solution, stirring
Machine stirs 20-45 minutes with the rotating speed of 60-120rpm under 35-48 degree Celsius, then carries out being evaporated to 1:1, stand 10-16
Filtered after hour, obtained supernatant and sediment;
Step 3, smalt leaf sap is added in supernatant and mixer is stirred with the rotating speed of 180-300rpm at normal temperatures
50-90 minutes are mixed, the product for stirring is put in drying box, drying box is dried under 45-60 degree Celsius, obtain
Two mixtures;
First mixture, sediment and the second mixture are well mixed and are crushed, added auxiliary material and make by step 4
Capsule, granular pattern electuary or tablet.
Compared with prior art, the invention has the beneficial effects as follows:Raw material sources of the present invention extensively, fit by preparation process is simple
For large-scale industrial production;In the present invention, the component such as smalt leaf sap, bupleurum particles, tylenol, brufen plays collaboration
Effect, formula are reasonable, easy to use, treatment rate and it is efficient be superior to existing product, no toxic and side effect, using effect are good.
Specific embodiment
The technical scheme of this patent is described in more detail with reference to specific embodiment.
Embodiment 1
A kind of Western medicine for treating febris acuta is combined, and is made up of according to weight portion following raw material:2 parts of auxiliary material, to second
5 parts of acylamino- phenol, 0.5 part of cellulose, 0.1 part of vitamin, amino acid/11 part, 5 parts of tylenol, 2 parts of brufen, smalt leaf sap 4
Part, 3 parts of 15 parts of ethanol solution, 1.5 parts of penicillin and the bupleurum particles that volume fraction is 52%, smalt leaf sap adopts folium isatidis
The mass fraction for being immersed in 6 times be 70% ethanol in 3 times, every time immersion 4 hours, merge soak and filter, collect filter
Liquid is obtained.Mixture of the auxiliary material using starch, lactose, xylitol and sucrose, cellulose adopt microcrystalline cellulose.
The preparation method that the Western medicine for treating febris acuta is combined, comprises the following steps that:
Tylenol, brufen and bupleurum particles are mixed and are crushed using pulverizer, after crushing by step one
Product crosses 30 mesh sieve, obtains the first mixture, gives over to standby;
Step 2, paracetamol, cellulose, vitamin, amino acid and penicillin are put in ethanol solution, stirring
Machine is stirred 20 minutes with the rotating speed of 60rpm under 35 degrees Celsius, then carries out being evaporated to 1:1, carried out after standing 10 hours
Filter, obtains supernatant and sediment;
Step 3, smalt leaf sap is added in supernatant and mixer is at normal temperatures with the rotating speed stirring 60 of 180rpm
Minute, the product for stirring is put in drying box, drying box is dried at 50 c, obtains the second mixture;
First mixture, sediment and the second mixture are well mixed and are crushed, added auxiliary material and make by step 4
Capsule, granular pattern electuary or tablet.
Embodiment 2
A kind of Western medicine for treating febris acuta is combined, and is made up of according to weight portion following raw material:It is 3.5 parts of auxiliary material, right
7 parts of Paracetamol, 1.5 parts of cellulose, 0.6 part of vitamin, 3 parts of amino acid, 8 parts of tylenol, 4 parts of brufen, smalt leaf juice
6 parts of liquid, 5 parts of 21 parts of ethanol solution, 3 parts of penicillin and the bupleurum particles that volume fraction is 60%, smalt leaf sap adopts smalt
Leaf is immersed in 2 times in the ethanol that 8 times of mass fraction is 70%, every time immersion 4.5 hours, is merged soak and is filtered, receives
Collection filtrate obtains.Vitamin adopts vitamin A and ascorbic mixture, and amino acid adopts the mixed of serine and aspartic acid
Compound.
The preparation method that the Western medicine for treating febris acuta is combined, comprises the following steps that:
Tylenol, brufen and bupleurum particles are mixed and are crushed using pulverizer, after crushing by step one
Product crosses 40 mesh sieve, obtains the first mixture, gives over to standby;
Step 2, paracetamol, cellulose, vitamin, amino acid and penicillin are put in ethanol solution, stirring
Machine is stirred 35 minutes with the rotating speed of 80rpm under 42 degrees Celsius, then carries out being evaporated to 1:1, carried out after standing 13 hours
Filter, obtains supernatant and sediment;
Step 3, smalt leaf sap is added in supernatant and mixer is at normal temperatures with the rotating speed stirring 75 of 240rpm
Minute, the product for stirring is put in drying box, drying box is dried at 50 c, obtains the second mixture;
First mixture, sediment and the second mixture are well mixed and are crushed, added auxiliary material and make by step 4
Capsule, granular pattern electuary or tablet.
Embodiment 3
A kind of Western medicine for treating febris acuta is combined, and is made up of according to weight portion following raw material:5 parts of auxiliary material, to second
10 parts of acylamino- phenol, 3 parts of cellulose, 1.5 parts of vitamin, 6 parts of amino acid, 10 parts of tylenol, 6 parts of brufen, smalt leaf sap 9
Part, 6 parts of 24 parts of ethanol solution, 4 parts of penicillin and the bupleurum particles that volume fraction is 60%, smalt leaf sap are soaked using folium isatidis
Steep 3 times in the ethanol that 8 times of mass fraction is 70%, every time immersion 4 hours, merge soak and filter, collect filtrate
Obtain.Mixture of the auxiliary material using starch, lactose, dextrin, xylitol, superfine silica gel powder, sucrose and glucose, cellulose adopt carboxylic
Methylcellulose.Mixture of the vitamin using vitamin A, vitamin B1, vitamin C and vitamin K, amino acid adopt silk ammonia
The mixture of acid, lysine, glutamic acid and aspartic acid.
The preparation method that the Western medicine for treating febris acuta is combined, comprises the following steps that:
Tylenol, brufen and bupleurum particles are mixed and are crushed using pulverizer, after crushing by step one
Product crosses 50 mesh sieve, obtains the first mixture, gives over to standby;
Step 2, paracetamol, cellulose, vitamin, amino acid and penicillin are put in ethanol solution, stirring
Machine is stirred 35 minutes with the rotating speed of 120rpm under 48 degrees Celsius, then carries out being evaporated to 1:1, carried out after standing 16 hours
Filter, obtains supernatant and sediment;
Step 3, smalt leaf sap is added in supernatant and mixer is at normal temperatures with the rotating speed stirring 60 of 300rpm
Minute, the product for stirring is put in drying box, drying box is dried at 60 c, obtains the second mixture;
First mixture, sediment and the second mixture are well mixed and are crushed, added auxiliary material and make by step 4
Capsule, granular pattern electuary or tablet.
400 patients, stochastic averagina are selected to be divided into 1-4 groups, per group of 100 people are essentially identical on the age of each group and sex,
Patient of the product of embodiment 1-3 to 1-3 groups is taken, existing product is taken to 4 groups of patient, 2g is simultaneously every time three times a day
And warm water delivery service is adopted, 2 days is a course for the treatment of, continues two courses for the treatment of, and treatment results are shown in Table 1.
Curative effect determinate standard:Recovery from illness:Heating paresthesia is wholly absent, and no longer recurs in three months.Take a turn for the better:Heating paresthesia mitigates
More than half.It is invalid:Heating paresthesia symptom does not mitigate or even increases.
Table 1
As it can be seen from table 1 the cure rate of embodiment 1-3 product and it is efficient be superior to existing product, therapeutic effect is good.
In use, patient does not have any discomfort to the product of embodiment 1-3, and patient avoids the excitant food such as pungent during taking medicine
Thing, avoids and drinks.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of spirit or essential attributes without departing substantially from the present invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that those skilled in the art should for clarity
Using specification as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, form those skilled in the art
Understandable other embodiment.
Claims (4)
1. a kind of Western medicine for treating febris acuta is combined, it is characterised in that be made up of according to weight portion following raw material:Auxiliary material
2-5 parts, paracetamol 5-10 parts, cellulose 0.5-3 parts, vitamin 0.1-1.5 parts, -6 parts of amino acid/11, tylenol 5-10
Part, brufen 2-6 parts, smalt leaf sap 4-9 parts, volume fraction are ethanol solution 15-24 parts of 50-60%, penicillin 1.5-4
Part and bupleurum particles 3-6 parts, smalt leaf sap adopt the mass fraction that folium isatidis is immersed in 5-8 times for 70% ethanol in 2-4
Secondary, immersion 4-5 hours, merge soak and filter every time, collect filtrate and obtain.
2. the Western medicine for treating febris acuta according to claim 1 is combined, it is characterised in that the auxiliary material is using shallow lake
One or several mixture of powder, lactose, dextrin, xylitol, superfine silica gel powder, sucrose and glucose, cellulose is using micro-
Crystalline cellulose or carboxymethylcellulose calcium.
3. the Western medicine for treating febris acuta according to claim 1 and 2 is combined, it is characterised in that the vitamin
Using one or several mixture of vitamin A, vitamin B1, vitamin C and vitamin K, amino acid using serine,
One or several mixture of lysine, glutamic acid and aspartic acid.
4. the preparation method that a kind of Western medicine for treating febris acuta as described in claim 1-3 is arbitrary is combined, its feature
It is to comprise the following steps that:
Tylenol, brufen and bupleurum particles are mixed and are crushed using pulverizer, the product after crushing by step one
30-50 mesh sieve is crossed, the first mixture is obtained, is given over to standby;
Step 2, paracetamol, cellulose, vitamin, amino acid and penicillin are put in ethanol solution, and mixer exists
With the rotating speed stirring 20-45 minutes of 60-120rpm under 35-48 degree Celsius, then carry out being evaporated to 1:1, stand 10-16 hours
After filtered, obtain supernatant and sediment;
Step 3, smalt leaf sap is added in supernatant and mixer is stirred with the rotating speed of 180-300rpm at normal temperatures
50-90 minutes, the product for stirring is put in drying box, drying box is dried under 45-60 degree Celsius, obtains second
Mixture;
First mixture, sediment and the second mixture are well mixed and are crushed, added auxiliary material and make capsule by step 4
Agent, granular pattern electuary or tablet.
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JP2020105133A (en) * | 2018-12-28 | 2020-07-09 | 株式会社アラクス | Pharmaceutical tablet |
Citations (1)
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CN1330920A (en) * | 2000-06-28 | 2002-01-16 | 哈尔滨中药三厂 | Process for preparing granular ibuprofen |
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CN1330920A (en) * | 2000-06-28 | 2002-01-16 | 哈尔滨中药三厂 | Process for preparing granular ibuprofen |
Cited By (2)
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JP2020105133A (en) * | 2018-12-28 | 2020-07-09 | 株式会社アラクス | Pharmaceutical tablet |
JP7231198B2 (en) | 2018-12-28 | 2023-03-01 | 株式会社アラクス | pharmaceutical tablet |
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Application publication date: 20170329 |