CN106530923A - Simulation eye with adjustable aberration based on spatial light modulator, and aberration adjustment method for simulation eye - Google Patents

Simulation eye with adjustable aberration based on spatial light modulator, and aberration adjustment method for simulation eye Download PDF

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CN106530923A
CN106530923A CN201610907657.5A CN201610907657A CN106530923A CN 106530923 A CN106530923 A CN 106530923A CN 201610907657 A CN201610907657 A CN 201610907657A CN 106530923 A CN106530923 A CN 106530923A
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aberration
emulation
eye
light modulator
spatial light
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CN106530923B (en
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江慧绿
李超宏
廖娜
厉以宇
陈浩
王勤美
黄锦海
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Wenzhou Medical University
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Abstract

The invention discloses a simulation eye with adjustable aberration based on a spatial light modulator, and an aberration adjustment method for the simulation eye. The simulation eye comprises a simulation cornea part, a simulation iris part, a simulation crystalline lens part, a simulation retina part, a housing, a transparent liquid, and a computer. The simulation crystalline lens part can employ the spatial light modulator, and the spatial light modulator is employed to achieve the change of aberration of human eyes. The simulation eye is ingenious and unique in design, can be used for replacing human eyes in ophthalmic instruments under various conditions, facilitates the ophthalmology teaching, provides a reliable and true human eye model, is convenient to operate, is high in efficiency, is high in precision, is good in authenticity, is wide in adjustment range, and can observe the imaging of an eye ground in real time.

Description

It is a kind of to be based on the adjustable simulated eye of spatial light modulator aberration and its aberration control method
Technical field
The present invention relates to the adjustable simulated eye technical field of the aberration for being related to combining adaptive optical technology, and in particular to one Plant based on the adjustable simulated eye of spatial light modulator aberration and its aberration control method.
Background technology
In ophthalmology department teaching or process of scientific research, the ophthalmic system of many ophthalmological instruments or research and development will use experimenter As check object, due to the system that there is student's improper use or research and development in teaching or process of scientific research unavoidably it is unstable etc. Factor, consequently, it is possible to cause the phenomenons such as experimenter's human eye injury;Meanwhile, the experimenter that interim urgent need or long-time coordinate is more difficult Find, these situations all can bring inconvenience to scientific research or teaching person;Additionally, everyone has different human eyes structures, It is most typical to have myopia, hypermetropia etc., different human eye aberrations will be produced when observing object, to checking that it is different that equipment is produced Effect, so a kind of adjustable simulated eye that can truly simulate human eye of human eye aberration of design has very important Research Significance. Additionally, different human eye difference viewing angles can produce different human eye aberrations, difference can be presented so as to observe optical fundus during object Conjugate image, realtime dynamic observation people ametropia are adjusted and cause the change of optical fundus conjugate image to have human eye aberration regulative mode Certain Research Significance, so be highly desirable to design a kind of device of energy real time dynamic simulation human eye aberration change.
The simulated eye for occurring in the market is essentially all static simulation eye, and many ophthalmological instruments are demarcated or test is all Using static simulation eye, it is impossible to adjustable to realize dioptric by changing simulation intraocular structure(Human eye aberration is adjustable), can not meet Function needed for teaching or scientific research, can only simulate various ametropia situations by adopting different dioptric simulated eyes, Observation of use instrument and the test of different human eyes is realized, its shortcoming inconvenient operation, efficiency are low, and verity is poor, and precision is low, it is impossible in real time The features such as dynamic observation.Additionally, also occurring there is few part on market with the adjustable simulated eye of simple dioptric, although can mould Intend hypermetropia or myopia, but be all deterministic simulation, it is impossible to accurately simulate or design various human eye aberrations, also truly cannot reflect Go out by human eye in image formed by optical fundus, its precision is low, and regulating power is weak, and verity is poor(It is true human eye to be simulated completely can not Aberration), it is impossible to the shortcomings of realtime dynamic observation.
In Chinese invention patent CN201210132443, a kind of adjustable simulated eye of diopter is described, people can only be changed The indivedual aberrations of eye, it is impossible to truly simulate human eye, also cannot truly reflect that ametropia human eye is being schemed formed by optical fundus by human eye As situation, visible patent CN201210132443 of particular content.Similar patent also has patent CN201610051712 etc., with regard to base Substantially do not saw in the adjustable simulated eye of spatial light modulator aberration and its real time dynamic simulation device patent.
Therefore, in the urgent need to a kind of based on the adjustable simulated eye of spatial light modulator aberration and its dress of real time dynamic simulation Put, according to different human eye aberrations, simulate true human eye aberration, realize observation and test, the eye observed in the case of various aberrations Bottom institute into image, can replace in any ophthalmological instrument equipment it is various in the case of human eye, and have easy to operate, efficiency high, High precision, verity are good, range of accommodation is wide, can Real Time Observation optical fundus imaging the features such as.
The content of the invention
The purpose of the present invention is to overcome above-mentioned shortcoming of the prior art, and the present invention provides a kind of based on space light modulation The adjustable simulated eye of device aberration and its aberration control method, the human eye aberration of the simulated eye continuously arbitrary face type can be adjusted, energy Various human eye aberrations are simulated, including higher order aberratons and low order aberration, facilitated ophthalmology department teaching, provided reliable true for Ophthalmologic apparatus Human-eye model, with easy to operate, efficiency high, high precision, verity is good, range of accommodation is wide, can Real Time Observation optical fundus institute into Picture the features such as.
The present invention adopt technical solution be:It is a kind of to be based on the adjustable simulated eye of spatial light modulator aberration, including Housing and computer, described housing rear is in indent dome shape, and the front end of described housing is sequentially provided with emulation from outside to inside Cornea part, emulation iris part, crystalline body component is emulated, the outside spherical protrusion of described emulation cornea part is described Emulate iridial part of retina and be located at emulation cornea part rear portion and against the crystalline body component of emulation, the described rear portion for emulating crystalline body component Simulated retinal part is additionally provided with, described simulated retinal part is arranged on the rear wall of housing, and described housing is simulated Crystalline body component is separated into ante-chamber and back cavity, and described ante-chamber and back cavity are respectively filled with immiscible transparency liquid, described Emulate cornea part, emulation iris part, emulate the front portion that crystalline body component is installed in ante-chamber, described computer and emulation Crystalline body component and simulated retinal part are respectively connected with.
Described emulation is crystalline, and body component includes lens, polaroid, transmission liquid crystal spatial modulator, described lens position In the front side or rear side of polaroid or transmission liquid crystal spatial modulator, described polaroid is adjusted positioned at transmission liquid crystal space Device front end processed.
Described transmission liquid crystal spatial modulator is made up of many little liquid crystal cells and corresponding liquid crystal cells electrode.
Described emulation is crystalline, and body component also includes controller and control software, and described controller is installed on housing, Described control software is installed on computers.
Described emulation cornea part is the thin transparent material of negative meniscus, and described emulation cornea part is that negative meniscus are thin One kind in lens or artificial cornea.
Described emulation iris part is variable light hole.
Described emulation is crystalline, and body component is spatial light modulator.
Described simulated retinal part is photoelectric sensor.
A kind of aberration control method based on the adjustable simulated eye of spatial light modulator aberration, described control method include Following steps:
(1)Crystalline body component will be emulated and simulated retinal part is linked together with described computer, described emulation is brilliant Shape body component is spatial light modulator;
(2)Known human eye is passed through into the calculated wave front aberration relevant parameter of wave front aberration detector or is artificially arbitrarily given Fixed wave front aberration relevant parameter, is manually entered in the control software of computer;
(3)Relation of the control software according to needed for wave front aberration parameter vector A and spatial light modulator between driving voltage vector V Formula, it is shown as the following formula, each unit electrode drive voltage value is calculated by wave front aberration parameter and aberration response matrix,
Wherein D is aberration response matrix, and its aberration response matrix can be obtained in the following way:Build the Adaptable System of M, described Adaptable System include Shack-Hartmann wavefront sensor M2 and simulated eye M1 and light source M3, described Shack- Beam splitting chip M8 is additionally provided between the line of Hartmann wave front sensor M2 and simulated eye M1, described light source M3's and beam splitting chip M8 Line is mutually perpendicular to the line of Shack-Hartmann wavefront sensor M2 and simulated eye M1, described light source M3 and beam splitting chip M8 Between be additionally provided with collimating lens M9;
The dot chart of optical system wavefront division is obtained by Shack-Hartmann wavefront sensor M2, human eye aberration is calculated in point Slope vector on the system of battle formations, the zeroth order aberration such as inclination, translation in separation slope vector, to eliminate the entirety of aberration in optical system Incline or translate, then, by the independent test to spatial light modulator cell electrode, obtain aberration correction spatial light modulator Aberration response matrix;
(4)Voltage value signal will be calculated and be sent to described controller, the cell electrode for controlling liquid crystal spatial modulator is driven Galvanic electricity pressure, by changing the driving voltage value being added on liquid crystal cells electrode, so that it may which pointwise controls the phase place of incident illumination, Jin Ershi The change of existing human eyes wave-front optical aberration.
The invention has the beneficial effects as follows:The invention provides a kind of be based on the adjustable simulated eye of spatial light modulator aberration, Including emulation cornea part, emulation iris part, emulate crystalline body component, simulated retinal part, housing, transparency liquid and meter Calculation machine;Described emulation is crystalline, and body component can adopt spatial light modulator, realize human eye picture by changing spatial light modulator Poor change, designs ingenious uniqueness, can replace in any ophthalmological instrument equipment it is various in the case of human eye, facilitate ophthalmology to teach Learn, reliable real human-eye model is provided for Ophthalmologic apparatus, and have that easy to operate, efficiency high, high precision, verity be good, tune Adjusting range is wide, can Real Time Observation optical fundus imaging the features such as.
Description of the drawings
Fig. 1 is the structure sectional view of the simulated eye specific embodiment of the present invention.
Fig. 2 is that the specific embodiment shown in Fig. 1 simulates bathomorphic structure sectional view.
Fig. 3 is that the specific embodiment shown in Fig. 1 simulates presbyopic structure sectional view.
Fig. 4 is the Adaptable System Experimental equipment of calculating aberration response matrix in simulated eye of the present invention.
Fig. 5 is the structural representation of the real time dynamic simulation human eye aberration changeable device specific embodiment of the present invention.
1- emulation cornea part in figure, 2- emulation iris parts, 3- emulate crystalline body component, 4- simulated retinal parts, 5- housings, 6- transparency liquids, 7- computers, 8- ante-chambers, 9- back cavities, 31- lens, 32- polaroids, 33- transmission liquid crystals space Manipulator, 34- controllers, 35- control softwares.
Specific embodiment
As shown in figure 1, a kind of be based on the adjustable simulated eye of spatial light modulator aberration, including housing(5)With computer (7), described housing(5)Rear wall be in indent dome shape, described housing(5)Front end be sequentially provided with emulation cornea from outside to inside Part(1), emulation iris part(2), emulate crystalline body component(3), described emulation cornea part(1)It is outwards spherical convex Go out, described emulation cornea part(1)For the thin transparent material of negative meniscus, described emulation cornea part(1)For negative meniscus One kind in thin lenss or artificial cornea.Described emulation iris part(2)For variable light hole.Described emulation crystalline lenses portion Part(3)For spatial light modulator.The change of human eye aberration, described emulation crystalline lenses are realized by changing spatial light modulator Part(3)Also include controller(34)And control software(35), described controller(34)It is installed to housing(5)On, it is described Control software(35)Installed in computer(7)On.Described emulation iris part 2 is located at emulation cornea part(1)Rear portion and tight By emulating crystalline body component(3), described emulation is crystalline body component(3)Rear portion be additionally provided with simulated retinal part 4, it is described Simulated retinal part 4 is photoelectric sensor.Described photoelectric sensor can be ccd sensor or cmos sensor etc..It is described Simulated retinal part 4 be arranged on housing(5)Rear wall on, described housing(5)Simulated crystalline body component(3)It is separated into Ante-chamber(8)And back cavity(9), described ante-chamber(8)And back cavity(9)Respectively filled with immiscible transparency liquid(6), described is saturating Prescribed liquid(6)Can be oil or water etc..Described emulation cornea part(1), emulation iris part(2), emulate crystalline body component (3)It is installed in ante-chamber(8)Front portion, described computer(7)With the crystalline body component of emulation(3)With simulated retinal part (4)It is respectively connected with.
Described emulation is crystalline body component(3)Including lens(31), polaroid(32), transmission liquid crystal spatial modulator (33), described lens(31)Positioned at polaroid(32)Or transmission liquid crystal spatial modulator(33)Front side or rear side, its Main purpose is to give simulated eye M1 mono- initial diopter, and aberration is adjusted by the transmission liquid crystal spatial modulator 33 Realize, positive negative direction regulation is carried out on the basis of given initial diopter;Described polaroid(32)Positioned at transmission liquid crystal Spatial modulator(33)Front end, for being converted into polarized light, described transmission liquid crystal spatial modulator by incident natural light It is made up of many little liquid crystal cells and corresponding liquid crystal cells electrode.Required people is input into by described control software 35 Wavefront aberration surface equation(Zernike polynomial can be adopted)Relevant parameter, according to wave front aberration and liquid crystal spatial modulator Relation needed for 33 between driving voltage calculates each unit electrode drive voltage value, and voltage value signal is sent to described control Device, controls the cell electrode driving voltage of liquid crystal spatial modulator, by changing the driving voltage being added on liquid crystal cells electrode Value, so that it may which pointwise controls the phase place of incident illumination, and then realizes the change of human eyes wave-front optical aberration.
The present invention can simulate human eye under different refractive status, for example, myopia state as shown in Figure 2, and as shown in Figure 3 Hypermetropia state, facilitate ophthalmology department teaching and system scientific research.
It is adjustable in order to realize simulated eye system aberration, it is in a particular embodiment of the present invention, a kind of to be based on space light modulation The aberration control method of the adjustable simulated eye of device aberration, described control method are comprised the following steps:
(1)Crystalline body component will be emulated(Spatial light modulator)With simulated retinal part(Photoelectric sensor)With described calculating Machine links together;
(2)Known human eye is passed through into the calculated wave front aberration relevant parameter of wave front aberration detector(Such as Ze Nike is multinomial Formula coefficient value)Or artificial any given wave front aberration relevant parameter, it is manually entered into the control software installed in computer In;
(3)Relation of the control software according to needed for wave front aberration parameter vector A and spatial light modulator between driving voltage vector V Formula, as shown in Equation 1, calculates each unit electrode drive voltage value by wave front aberration parameter and aberration response matrix,
(1)
Wherein D is aberration response matrix, and its aberration response matrix can be obtained in the following way:Build the Adaptable System of M, as shown in figure 4, described Adaptable System includes Shack-Hartmann wavefront sensor M2 and simulated eye M1 and light source M3, Beam splitting chip M8, described light source M3 is additionally provided between described Shack-Hartmann wavefront sensor M2 and the line of simulated eye M1 It is mutually perpendicular to the line of Shack-Hartmann wavefront sensor M2 and simulated eye M1 with the line of beam splitting chip M8, described light source Collimating lens M9 is additionally provided between M3 and beam splitting chip M8;
The dot chart of optical system wavefront division is obtained by Shack-Hartmann wavefront sensor M2, human eye aberration is calculated in point Slope vector on the system of battle formations, the zeroth order aberration such as inclination, translation in separation slope vector, to eliminate the entirety of aberration in optical system Incline or translate, then, by the independent test to spatial light modulator cell electrode, obtain aberration correction spatial light modulator Aberration response matrix;
(4)Voltage value signal will be calculated and be sent to described controller, the cell electrode for controlling liquid crystal spatial modulator is driven Galvanic electricity pressure, by changing the driving voltage value being added on liquid crystal cells electrode, so that it may which pointwise controls the phase place of incident illumination, Jin Ershi The change of existing human eyes wave-front optical aberration.
In order to realize that realtime dynamic observation human eye aberration changes the optical fundus for causing institute into image change situation, in present invention tool In body embodiment, as shown in figure 5, a kind of real time dynamic simulation device based on the adjustable simulated eye of spatial light modulator aberration, Including wave front detector M2 and simulated eye M1 and light source M3 and the dead ahead of head rest and human eye M4, described head rest and human eye M4 Moving stage and object M5 is additionally provided with, described head rest and human eye M4 are passed with wavefront with the line of moving stage and object M5 The line of sensor M2 and simulated eye M1 is mutually perpendicular to, and described simulated eye M1 is set respectively with the front end of moving stage and object M5 There is visible band pass filter M6, described visible band pass filter M6 main purposes are to filter off in addition to visible ray Other veiling glares, are used for observing object using visible ray, and near infrared light is detected for aberration, and observation and aberration detection are separated, and are had Beneficial to the realization of function, the front end of described light source M3 is additionally provided with collimating lens M9, described light source M3 and Wavefront sensor M2 And the line of simulated eye M1 between and head rest and human eye M4 and moving stage and object M5 line and Wavefront sensor M2 Beam splitting chip M8 is respectively equipped with the intersection of the line of simulated eye M1, between two described beam splitting chip M8, near-infrared band is additionally provided with Pass filter M7.Described near-infrared bandpass filter M7 main purposes are to filter the visible ray Jing people sent by object M5 The visible ray that eye M4 and simulated eye M1 is reflected back, reduces impact of the veiling glare to wavefront sensing accuracy.
Described wave front detector M2 can be Shack-Hartmann wave front detector.
Described light source M3 is super-radiance light emitting diode or laser, and wavelength selects near infrared band.Reduce eyes pair The sensitivity of light causes lenticular regulation, so as to affect observation of the human eye to object.
A kind of real time dynamic simulation method of real time dynamic simulation device, the step of implement and method is as follows:
(1)Human eye M4 observes object M5, and the light that object M5 sends filtered M6 and beam splitting chip M8 enters into human eye M4, cause Crystalline lenses are adjusted, and see object clearly to reach, meanwhile, the collimated lens M9 collimations of light sent by light source M3 incide human eye M4, the light come by human eye M4 fundus reflexes, then Jing beam splitting chips M8 and optical filter M7 are entered in wave front detector M2, are passed through Wavefront sensor M2 obtains the dot chart of optical system wavefront division, is sent on computer, by computed in software human eye aberration Slope vector on dot chart, such that it is able to reconstruct wave front equation, obtains human eye aberration parameter value;
(2)Each unit electrode voltage value is calculated according to aberration parameter vector, will be calculated voltage value signal be sent to it is described Simulated eye M1, control the cell electrode voltage of liquid crystal spatial modulator 33, make simulated eye M1 system aberrations and now human eye M4 Aberration is consistent, so as to accurately simulate human eye;
(3)By mobile object M5, human eye can adjust crystalline honorable type to see object M5 clearly, so as to change human eye aberration, eye Image formed by bottom becomes clear by fuzzy, and simulated eye M1 can go out human eye picture with real-time Simulation by feeding back the dynamic aberration for coming Difference, image formed by optical fundus are shown on computers by photoelectric sensor 4, so as to be capable of achieving realtime dynamic observation human eye The optical fundus institute that aberration change causes is into image change situation.
The present invention's is ingenious based on the adjustable simulated eye of spatial light modulator aberration and its design of real time dynamic simulation device Uniqueness, can replace in any ophthalmological instrument equipment it is various in the case of human eye, facilitate ophthalmology department teaching, providing for Ophthalmologic apparatus can By real human-eye model, and have easy to operate, efficiency high, high precision, verity is good, range of accommodation is wide, energy Real Time Observation The features such as optical fundus imaging, it is suitable to large-scale promotion application.
The above is only the preferred embodiment of the present invention, and protection scope of the present invention is not limited merely to above-mentioned enforcement Example, all technical schemes belonged under thinking of the present invention belong to protection scope of the present invention.It should be pointed out that for the art Those of ordinary skill for, some improvements and modifications without departing from the principles of the present invention, these improvements and modifications Should be regarded as protection scope of the present invention.

Claims (9)

1. it is a kind of to be based on the adjustable simulated eye of spatial light modulator aberration, including housing(5)With computer(7), described housing (5)Rear wall is in indent dome shape, it is characterised in that described housing(5)Front end be sequentially provided with emulation cornea portion from outside to inside Part(1), emulation iris part(2), emulate crystalline body component(3), described emulation cornea part(1)Outside spherical protrusion, Described emulation iris part(2)Positioned at emulation cornea part(1)Rear portion and against the crystalline body component of emulation(3), described is imitative Very crystalline body component(3)Rear portion be additionally provided with simulated retinal part(4), described simulated retinal part(4)Installed in shell Body(5)Rear wall on, described housing(5)Simulated crystalline body component(3)It is separated into ante-chamber(8)And back cavity(9), it is described before Chamber(8)And back cavity(9)Respectively filled with immiscible transparency liquid(6), described emulation cornea part(1), emulation iridial part of retina Part(2), emulate crystalline body component(3)It is installed in ante-chamber(8)Front portion, described computer(7)With the crystalline body component of emulation (3)With simulated retinal part(4)It is respectively connected with.
2. it is according to claim 1 a kind of based on the adjustable simulated eye of spatial light modulator aberration, it is characterised in that described The crystalline body component of emulation(3)Including lens(31), polaroid(32), transmission liquid crystal spatial modulator(33), described is saturating Mirror(31)Positioned at polaroid(32)Or transmission liquid crystal spatial modulator(33)Front side or rear side, described polaroid(32) Positioned at transmission liquid crystal spatial modulator(33)Front end.
3. it is according to claim 2 a kind of based on the adjustable simulated eye of spatial light modulator aberration, it is characterised in that described Transmission liquid crystal spatial modulator be made up of many little liquid crystal cells and corresponding liquid crystal cells electrode.
4. it is according to claim 2 a kind of based on the adjustable simulated eye of spatial light modulator aberration, it is characterised in that described The crystalline body component of emulation(3)Also include controller(34)And control software(35), described controller(34)It is installed to housing (5)On, described control software(35)Installed in computer(7)On.
5. it is according to claim 1 a kind of based on the adjustable simulated eye of spatial light modulator aberration, it is characterised in that described Emulation cornea part(1)For the thin transparent material of negative meniscus, described emulation cornea part(1)For negative meniscus thin lenss or One kind in artificial cornea.
6. it is according to claim 1 a kind of based on the adjustable simulated eye of spatial light modulator aberration, it is characterised in that described Emulation iris part(2)For variable light hole.
7. it is according to claim 1 a kind of based on the adjustable simulated eye of spatial light modulator aberration, it is characterised in that described The crystalline body component of emulation(3)For spatial light modulator.
8. it is according to claim 1 a kind of based on the adjustable simulated eye of spatial light modulator aberration, it is characterised in that described Simulated retinal part(4)For photoelectric sensor.
9. the aberration control method based on the adjustable simulated eye of spatial light modulator aberration described in a kind of claim 1, which is special Levy and be, described control method is comprised the following steps:
(1)Crystalline body component will be emulated and simulated retinal part is linked together with described computer, described emulation is brilliant Shape body component is spatial light modulator;
(2)Known human eye is passed through into the calculated wave front aberration relevant parameter of wave front aberration detector or is artificially arbitrarily given Fixed sorry aberration relevant parameter, is manually entered in the control software of computer;
(3)Relation of the control software according to needed for wave front aberration parameter vector A and spatial light modulator between driving voltage vector V Formula, it is shown as the following formula, each unit electrode drive voltage value is calculated by wave front aberration parameter and aberration response matrix,
Wherein D is aberration response matrix, and its aberration response matrix can be obtained in the following way:Build the Adaptable System of M, described Adaptable System include Shack-Hartmann wavefront sensor M2 and simulated eye M1 and light source M3, described Shack- Beam splitting chip M8 is additionally provided between the line of Hartmann wave front sensor M2 and simulated eye M1, described light source M3's and beam splitting chip M8 Line is mutually perpendicular to the line of Shack-Hartmann wavefront sensor M2 and simulated eye M1, described light source M3 and beam splitting chip M8 Between be additionally provided with collimating lens M9;
The dot chart of optical system wavefront division is obtained by Shack-Hartmann wavefront sensor M2, human eye aberration is calculated in point Slope vector on the system of battle formations, the zeroth order aberration such as inclination, translation in separation slope vector, to eliminate the entirety of aberration in optical system Incline or translate, then, by the independent test to spatial light modulator cell electrode, obtain aberration correction spatial light modulator Aberration response matrix;
(4)Voltage value signal will be calculated and be sent to described controller, the cell electrode for controlling liquid crystal spatial modulator is driven Galvanic electricity pressure, by changing the driving voltage value being added on liquid crystal cells electrode, so that it may which pointwise controls the phase place of incident illumination, Jin Ershi The change of existing human eyes wave-front optical aberration.
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