CN106527375A - Production process execution system for pharmaceutical company - Google Patents
Production process execution system for pharmaceutical company Download PDFInfo
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- CN106527375A CN106527375A CN201611138187.7A CN201611138187A CN106527375A CN 106527375 A CN106527375 A CN 106527375A CN 201611138187 A CN201611138187 A CN 201611138187A CN 106527375 A CN106527375 A CN 106527375A
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 91
- 238000007726 management method Methods 0.000 claims abstract description 106
- 238000012544 monitoring process Methods 0.000 claims abstract description 31
- 238000004891 communication Methods 0.000 claims abstract description 4
- 238000013523 data management Methods 0.000 claims abstract description 4
- 238000000354 decomposition reaction Methods 0.000 claims abstract description 4
- 230000002457 bidirectional effect Effects 0.000 claims abstract description 3
- 239000003814 drug Substances 0.000 claims description 5
- 238000012351 Integrated analysis Methods 0.000 claims description 3
- 230000007306 turnover Effects 0.000 claims description 3
- 230000010354 integration Effects 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 description 70
- 238000005453 pelletization Methods 0.000 description 23
- 230000008569 process Effects 0.000 description 23
- 238000002156 mixing Methods 0.000 description 19
- 239000000463 material Substances 0.000 description 17
- 238000001035 drying Methods 0.000 description 15
- 238000002360 preparation method Methods 0.000 description 14
- 239000007787 solid Substances 0.000 description 14
- 238000005516 engineering process Methods 0.000 description 11
- 230000001276 controlling effect Effects 0.000 description 10
- 239000008187 granular material Substances 0.000 description 10
- 238000005469 granulation Methods 0.000 description 7
- 230000003179 granulation Effects 0.000 description 7
- 230000008859 change Effects 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000005484 gravity Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000013515 script Methods 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 238000012858 packaging process Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
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- 238000012423 maintenance Methods 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010063385 Intellectualisation Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- -1 electricity Substances 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012806 monitoring device Methods 0.000 description 1
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- 238000004886 process control Methods 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
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Classifications
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
- G05B19/41865—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM] characterised by job scheduling, process planning, material flow
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/32—Operator till task planning
- G05B2219/32252—Scheduling production, machining, job shop
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Quality & Reliability (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Automation & Control Theory (AREA)
- General Factory Administration (AREA)
Abstract
The invention discloses a production process execution system for a pharmaceutical company, and the production process execution system can realize on-site, local and/or remote automatic monitoring and management. The production process execution system comprises a local control management layer which is respectively connected to an on-site control layer of the local control management layer and a remote monitoring and management layer. The production process execution system further comprises a company management layer connected to the remote monitoring and management layer. Key task information related to product behavior is provided in the company and an entire pharmaceutical product supply chain through bidirectional direct communication of the system. The production process execution system further comprises management modules for manufacture data management, plan scheduling management, production scheduling management, stock management, quality management, human resource management, work center/equipment management, tool management, purchase management, cost management, project billboard management, production process control, underlying data integration and analyzing and upper layer data integration and decomposition for the company.
Description
Technical field
The present invention relates to a kind of pharmacy system.More particularly to a kind of pharmacy corporation production process execution system.
Background technology
Solid preparation equipment is generally split setting, single-set operation, management and control in the market, lacks a set of energy complete
The intelligent information management system of whole solid preparation production equipment information is reacted in face, its unit dispersion, handled by itself operation pipe
Reason is respectively present the diversity such as larger randomness, asynchronous, uncoordinated, so that affecting production effect and efficiency, Er Qiefeng
Closing property is also poor, while realizing that intellectualization of factories management brings very big obstacle to enterprise.
The content of the invention
The present invention there is above-mentioned deficiency for prior art, there is provided one kind can meet comprehensively, adapt to and optimize medicine or
Solid preparation manufacturing technique requirent, meet, adapt to, give full play to and optimize its corresponding production equipment service requirement, realize just
Ground, the pharmacy corporation production process execution system of locally and/or remotely automatic monitoring management.
The technical scheme of this pharmacy corporation production process execution system includes locally controlling management level, is connected to described
The field control layer and remote monitoring and administration layer of local control management level；It is characterized in that also including being connected to the remote monitoring pipe
The enterprise management level of reason layer, its Direct Communication for passing through system bidirectional are carried in the whole product supply chain of enterprises and medicine
For relevant product line for mission critical information also include for enterprise provide Manufacturing Data Management, plan scheduling management, production adjust
Degree management, stock control, quality management, human resource management, work centre/equipment control, instrument tool management, buying pipe
The pipes such as reason, cost management, project kanban system, production process control, bottom data integrated analysis and the integrated decomposition of upper layer data
Reason module.
Also include tracking manufacturing schedule, inventories, the job schedule letter related to the operation management in other turnover workshops
Breath stream.
The pharmacy corporation production process execution system of the present invention is from feeding intake, crush, weigh, pelletize, be dried, granulate, mixing,
The all devices of tabletting, coating, on-line cleaning and packaging process full process stream journey carry out distributed and coordinated control, centralized pipe
Reason so that the operation of equipment more science, rationally, the comprehensive operation efficiency of equipment is higher so that whole production process link is more
Coordinate, more save, the waste of raw material, and then improve production efficiency, saving production can also be avoided.The system is with industry control
Technology processed, using powerful configuration software and field bus technique, using modularized design thinking, can integrated data adopt
Collection detection, produces the multiple functions such as interlocked control, parameter off-limit alarm, data filing, emergency review, remote monitoring, is pharmacy
Industry and enterprise management provides very important administration base, and designing and developing for its whole system all can be in current state-of-the-art technology
On platform, no matter realization, its bob and strong applicability, all ensured that in industrial application from hardware or software development
Science, reasonable, practical, advanced and operability.It is particularly well-suited to the equipment control of pharmaceutical industry pharmaceutical workshop.Simultaneously
Realize that the target of intelligent plant provides important technical support for enterprise.
Description of the drawings
Fig. 1 is solid preparation KXG entire block diagram of the present invention；Fig. 2 is the information-based pipe of solid preparation of the present invention
Reason systems soft ware functional block diagram；Fig. 3 is another embodiment entire block diagram of invention solid preparation KXG；Fig. 4 is
One example structure schematic diagram of integral type mixture manufacturing line of solid preparation KXG of the present invention.
Specific embodiment
Below by embodiment and combine accompanying drawing to the present invention described in detail.As illustrated in fig. 1 and 2.This pharmacy corporation
Production process execution system 19 includes locally controlling management level 1, is connected to the field control layer of local control management level 1
（Or site controling management layer）2nd, and remote monitoring and administration layer 3, pharmacy corporation production process execution system is corresponding by which
System control management function module and pass through field control layer by main control computer, also or by main control computer and remote computer
Intelligent controlling device（Or intelligent station）, on-site producing devices 12, production technology are run accordingly, operation is monitored
Management, 3 pairs, its remote monitoring and administration layer locally control management control system including local control management level of management level 1 etc.
Operation is monitored management.
Its remote monitoring and administration layer also including to the operation comprising the local control management level including main control computer and
Field control layer, the operation troubles of corresponding on-site producing devices including intelligent controlling device is analyzed diagnosis.
In this example, its remote monitoring and administration layer 3 includes remote computer（Also or Terminal Server Client）7 and its mobile terminal 9,
The local control management level 1 include main control computer（Also or local client）4th, corresponding traffic device, its field control and/
Or management level 2 include being connected to the corresponding intelligent controlling device of corresponding on-site producing devices or device 12.Its intelligence
Control device includes PLC 11.Its main control computer is connected with various external equipments 10, corresponding ups power etc..Which is long-range
Monitoring management layer can also be monitored management to the operation of local control management level.
Profibus field bus techniques are selected in the connection of local control management level 1 and field control layer 2.
The intelligent controlling device（Or intelligent station）Including intelligent controller（PLC) 11, a PLC
Controller 11 can be connected to the corresponding production equipment in corresponding one or more scene or device 12.
The on-site producing devices or device 12 include dustless crushing feeding station or device, wet granulator, boiling granulating
The whole production process equipment such as machine drying device, mixing arrangement, preforming device and full-automatic hopper cleaning machine.
Its remote monitoring and administration layer also by local control management level or its main control computer remote monitoring and/or manages existing
The ruuning situation of field device.
Implement running status and/or the use of remote monitoring on-site producing devices in view of preferably production needs are met
Situation, this pharmacy corporation production process execution system integrally adopt B/S structures（Browser/Server browser/servers are tied
Structure）, it is built upon a kind of brand-new software system construction system on the basis of wide area network, by Wincc Web
Navigator options, with WWW browser technologies, with reference to various script scripts and Active technologies of browser, and
Terminal Server Client need not install configuration software, only need to key in corresponding IP address in IE browser, and user can monitoring project fortune
OK.This pharmacy corporation production process execution system also includes mobile terminal server：Its mobile terminal server passes through WebUX skills
Art may be implemented in monitoring device operation on various intelligent mobile terminals.This pharmacy corporation production process execution system is in remote client
Increase firewall protection between end and local client, the whole system of this pharmacy corporation production process execution system can be effectively improved
The safety of system.
Corresponding traffic device of this pharmacy corporation production process execution system its local control management level includes master server
And redundant server.Locally control management level and adopt redundancy structure, that is, the version of master server and redundant server,
Realized under the mode of operation not broken down by Wincc redundancy technologies, master server is in Host Status, and
Redundant server is in guest machine state.Once breaking down, then the state of master server will be changed into invalid, and local client will
Redundant server can be switched to, all of process values and message will be processed on two-server and be filed so that client
Machine（Including Terminal Server Client, local client etc.）On operation and monitoring system process hardly occur interrupt.
Profibus is selected in the local control management level of pharmacy corporation production process execution system and field control layer connection
Field bus technique.Profibus field bus techniques have the advantages of stability is high, and transfer rate is fast.
This pharmacy corporation production process execution system 19 its monitoring management functional module includes equipment file management module 13,
Monitoring of tools picture module 14, User logs in and authority distribution management module 15, data record filing and trendgram management module
18, statement management module 16 and message system management 17 pieces of mould.It is that its software program function aspects mainly divides above-mentioned six functions
Module.
Its equipment files module stores has an essential information of each equipment, equipment maintenance information, device using information,
Numbering which may also include equipment, operational factor, use, attended operation personal information etc..By SQL in its equipment files module
2000 data bases of Server can manage the essential information of each equipment, equipment maintenance information, device using information etc., can
So that user is to the very clear of the various information of equipment.
Its monitoring of tools picture module includes profibus drivers.In the module, journey is driven by profibus
Sequence is set up and scene in the monitoring system of the pharmacy corporation production process execution system or its local control management level of the present invention
Control and/or each intelligent station key process parameter of management level（Including switching value and analog quantity）Connection.In its monitoring
Key frame be distinguished into four parts：Header area, functional module area, equipment operation picture monitored space, Warning alarm area.Header area master
It is by compositions such as device name, numbering, operator, production material and lot number, clocks；Equipment is broadly divided in functional module area
Switching, the inquiry of equipment service condition, historical record inquiry are printed, and trendgram inquiry, inquiry of reporting to the police, user management log off
Deng functional keyss, different functional pictures are switched to by the functional keyss for clicking on different；Picture monitored space master is run in equipment
The value and state of key process parameter are shown in real time, and numerical value transfinites or state change is intuitively shown by different colours；Warning
Zone of alarm, be mainly used in show the set system monitoring all devices Realtime Alerts information, for the report of different significance levels
Alarming information is shown using different colours.
User logs in and authority distribution management module：User Manager creates system user and carries out authority distribution.Pass through
Function access filing data storehouse mode defined in dynamic link library, realizes changing login password under operation and user cuts
Change, the operation such as user log off.
Data record is filed and trendgram management module：The process values storage for gathering is arrived SQL in run duration by system
In 2000 project filing data storehouses of Server.With wincc online table control and wincc online
Trend control controls show the process data of filing respectively in the way of form and trendgram.
Statement management module includes 2000 data bases of SQL Server.Which utilizes the SQL Server 2000 of configuration software
Database needs the data form filed, the process of filing to pass through the VB- of Wincc global scripts
Script realizations, automatic produces day form and moon sheet, user can browse statistical report form with selectivity.Form can be imported to
Check in EXCEL.
Message system module includes alarm logging editing machine, alarm controller etc..Which uses alarm logging editing machine configuration
Time of fire alarming, warning message triggering variable, type of alarm, erroneous point, warning message text, warning reason analysis information etc..It is logical
Cross wincc alarm control controls and realize that the displaying live view to warning message, short-term are filed, long term archival, confirmation and sieve
The functions such as choosing, screening function can carry out classification and check according to the warning classification for showing, warning device, and can be to showing in current control
The fault message preview shown, completes the printing of fault alarm form.
The production of this pharmacy corporation production process execution system its solid preparation（Technique）Management control method includes：To from
Feed intake, crush, weighing, pelletizing, being dried, granulate, mixing, tabletting, coating, whole technological processes of on-line cleaning and packaging process
All equipment used carry out distributed AC servo system, centralized management, using can integrated data acquisition testing, production interlocking control
The production to solid preparation such as system, parameter off-limit alarm, data filing, emergency review, remote monitoring carries out whole coordination, system
One, the management of integrated dispatch control manipulation.
In embodiments of the invention 2, this pharmacy corporation production process execution system also includes data acquisition unit, data acquisition
Device is connected between main control computer or/and intelligent controller and corresponding on-site producing devices, by corresponding data acquisition unit
Related data, information to live each production equipment, the such as information such as device label, numbering carry out detection collection, and pass through data
Line or by wireless transmission is to main control computer or is transferred to main control computer remote computer and/or corresponding
Intelligent controller.With production technology, operation by system master computer and/or intelligent controlling device to corresponding solid preparation
Operation carries out corresponding policer operation management.Remaining system structure of the present embodiment, control mode method and above-described embodiment class
Together.
Its system function module software program of the invention can assist it is embedding be stored in main control computer or main control computer,
Remote computer and corresponding intelligent controller etc..
In embodiments of the invention 3, this pharmacy corporation production process execution system also includes A/D converter, and the modulus turns
Parallel operation be connected to intelligent controlling device or intelligent controller and main control computer and corresponding on-site producing devices sensor it
Between, the related process parameters of equipment being detected by corresponding sensor, the quality of material such as weighed located at weighing apparatus is sensed
Device, located at corresponding drying device（Drying machine）Baking temperature sensor, it is the tableting pressure sensor of preforming device, corresponding
Mass flow rate sensing etc., by analog signalses of its sensor to the corresponding processing parameter of on-site producing devices
Carry out detecting, change after be transferred to intelligent controlling device and/or main control computer.With by system master computer, remote computation
Machine and/or intelligent controlling device pass through corresponding systems soft ware（System monitoring management function module）To produced on-site technological operation
Enforcement overall process is synchronous, coordinated monitoring operation management.Remaining system structure of the present embodiment, control mode method etc. can with it is above-mentioned
Any embodiment is similar.
Embodiment 4, the production management of this pharmacy corporation production process execution system its solid preparation specifically control technique stream
Journey（Or process）Including：By the corresponding monitoring management functional module of this intelligent informationization management system, Jing scenes intelligence
Energy control device and corresponding performs device implement the circulation of the material in all round process with rectilinear layered arrangement：Material send
It is upper top, circulated toward lower floor with flow process operation successively, using the gravity of material, completed the conveying transfer of material.This life
Produce control process to can be very good to solve to need multi storied factory building due to vertical demixing arrangement, per layer be both needed to arrange people it is net,
The net system of thing, and flow process be coupled contact inconvenience with management the problems such as, that is, improve production efficiency, saved manpower, thing again
Power and power consumption, also optimize the technological process of production, it is easier to realize the closed mode of production of isolation, purified production scene
Environment.The control that continually artificial turn of material and thing followed cross-contamination are preferably solved with dust is actual production work
Person, manager, researcher more stubborn problem.Embodiment 5, this pharmacy corporation production process execution system its solid
The production management of preparation specifically controls technique（Flow process）Method includes：With plane formula auxiliary conveying arrangement：By this intelligent information
Change the corresponding functional module of management system, site intelligent control device and implement the circulation of the material in production process with flow process
Based on horizontal layout, using the special material transfer equipment of series, in making solid preparation production procedure, each operation organically joins
System gets up, and reaches the unobstructed purpose of flow process.Its plane auxiliary conveying arrangement advantage becomes apparent from.Plus a series of matched
Material transfer equipment be proven convenient and reliable, some process equipments being adapted with this flow process are able to effective and sufficient
Utilize.
Embodiment 6 is as shown in Figure 3.The present invention also performs system by remote monitoring and administration layer building manufacturing enterprise production process
System（Enterprise's MES management systems）, and then constitute enterprise management level 19.Relevant interface is passed through by correlation by enterprise MES management systems
The production schedule is with plant working scene by including PLC, data acquisition unit, bar code, corresponding metering and sensor
And/or the performs device of mechanical hand is linked to each other, and supplied in enterprises and whole product by two-way Direct Communication
The mission critical information that relevant product line is is provided in answering chain, cooperation is set up including with the manufacturer for providing production scene control facility
Relation, for enterprise provide including Manufacturing Data Management, plan scheduling management, Production scheduling management, stock control, quality management,
Human resource management, work centre/equipment control, instrument tool management, purchasing management, cost management, project kanban system, life
The management modules such as process control, bottom data integrated analysis, the integrated decomposition of upper layer data are produced, also including tracking manufacturing schedule, storehouse
Deposit situation, the job schedule flow of information related to the operation management in other turnover workshops.It is such as when factory occurs real-time event, right
This makes a response in time, report, and with current accurate data to being instructed and being processed.By corresponding information transmission to from
Order placement is optimized management to the whole production process that product is completed.For enterprise make one it is sturdy, reliable, comprehensively, can
Capable manufacture cooperating management platform.
State change is responded rapidly to using enterprise's MES management systems, can reduce enterprises does not have added value
Activity, effectively instructs the production operation of factory, so which can improve factory's punctual delivery ability, improves material
Trafficability performance, and production return rate can be improved.
In the embodiment of the present invention 7, its described production technology includes feeding intake, crush, claiming for medicine or the production of its solid preparation
Amount, granulation, are dried, the full process stream journey of granulate, mixing, tabletting, coating, on-line cleaning and/or packaging process.
In the embodiment of the present invention 8, its described production technology includes the granulation of medicine or its pharmaceutical workshop, drying, whole
Grain, the whole production technology of mixed processes, which realizes closed line production from wet-mixed granulation to hopper mixing whole process.
Embodiment 9 is as shown in Figure 4.Pharmacy corporation production process execution system of the present invention its on-site producing devices（System）For
Integral type mixture manufacturing line, whole production line or system are divided into some subsystems by which, and its each subsystem presses technique sequencing
Mutually correspondence or connect successively, which is each to be connected by being flexible coupling accordingly, wired hose connection and/or clip are closed hardwired
Mode is attached, and its each subsystem is controlled by field control layer or its intelligence by management level or its main control computer is locally controlled
Device processed implements full automatic working management control.
The operation position of all subsystems is all exposed, the mutual level of relevant device or device of each subsystem or/
With the outer surface for being installed vertically on mobile platform, the power section of its device is all built-in.Both full packaged type had been realized
Production, again for need to provide during artificial intervention may and conveniently.
Its subsystem includes wet-mixed granulation subsystem, wet method granulate subsystem, is dried subsystem, vacuum feeding subsystem
System, dry method granulate subsystem and hopper mixing subsystem.
Its wet-mixed granulation subsystem, wet method granulate subsystem, to be dried subsystem, vacuum feeding subsystem, dry method whole
ParticIe system and hopper mixing subsystem are respectively by wet mixing pelletizer 2, wet method pelletizing machine 3, drying machine 5, vacuum feeder
7th, dry method pelletizing machine 8 and hopper mixer 9 are constituted as main equipment device.
The concrete structure and the mode of production of the present embodiment is as shown in Figure 4.I.e.：Its integral type mixture manufacturing line in the present embodiment
Comprising the wet-mixed granulation subsystem, wet method granulate subsystem, drying that are mutually corresponded to by technique sequencing successively or connected
Subsystem, vacuum feeding subsystem, dry method granulate subsystem and hopper mixing subsystem.Its each subsystem is managed by local control
Layer or its main control computer implement control by intelligent controller 11.Its wet-mixed granulation subsystem, wet method granulate subsystem,
Subsystem, vacuum feeding subsystem, dry method granulate subsystem and hopper mixing subsystem are dried respectively by wet mixing pelletizer
2nd, wet method pelletizing machine 3, drying machine 5, vacuum feeder 7, dry method pelletizing machine 8 and hopper mixer 9 as main equipment device structure
Into.
The wet mixing pelletizer 2 of each subsystem, wet method pelletizing machine 3, drying machine 5, vacuum feeder 7, dry method pelletizing machine 8
Connected by corresponding pipeline etc. in order and the relevant hardware devices such as hopper mixer 9 between.
The corresponding input of field control layer or its intelligent controller 11 respectively by corresponding electric signal line with it is each
Subsystem including wet mixing pelletizer 2, wet method pelletizing machine 3, drying machine 5, vacuum feeder 7, dry method pelletizing machine 8 and hopper
Mixer 9 is in interior all relevant devices or the electric signal detector of device（Sensor）Connection.Field control layer or its intelligence
Can controller corresponding outfan respectively by corresponding electric signal line and the wet mixing pelletizer 2 of each subsystem, wet
Method pelletizing machine 3, drying machine 5, vacuum feeder 7, dry method pelletizing machine 8 and hopper mixer 9 and its corresponding auxiliary device are interior
The executor of all relevant devices or device is connected.Its executor includes servo amplifier, autocontrol valve, regulating valve, electricity
Stream, voltage regulator, motor speed actuator, variable frequency adjustment device etc..
The wet mixing pelletizer 2 of each subsystem, wet method pelletizing machine 3, drying machine 5, vacuum feeder 7, dry method pelletizing machine 8
Its field control layer or its intelligent controller control system are passed through by its main control computer equally with 9 grade relevant device of hopper mixer
One provides corresponding resource or power, the such as resource requirement such as water, electricity, gas.
Its field control layer or its intelligent controller control are passed through to including the whole of subsystems by main control computer
Production process implements whole-process automatic monitoring operation management control.Wet mixing pelletizer 2, wet method pelletizing machine 3, drying machine 5,
Vacuum feeder 7, dry method pelletizing machine 8, hopper mixer 9 and field control layer 2 or its PLC 11 are fully integrated and are installed on
On same mobile platform 1.
The working position of all subsystems all exposes, and is horizontally or vertically installed on the outer surface of mobile platform, power part
Divide all built-in.The material of wet mixing pelletizer in stirring paddle and self gravitation effect, bottom discharge, in wet granulator.
Wet mixing pelletizer 2 is connected with each other in upper-lower position with wet method pelletizing machine 3.Wet mixing pelletizer is whole with wet method
Grain machine, uses the closed Hard link of clip between vacuum feeder and dry method pelletizing machine.
Vacuum feeder 7 installs the top that is placed in dry method pelletizing machine 8 with bottom is mutually presented.The material of dry method pelletizing machine 8
Entered in drying machine by the closed line of wired hose under self gravitation effect,.
Drying machine 5 is connected with each other by wired hose 11 with vacuum feeder 7.Material in drying machine 5 is in gravity and very
Entered in vacuum feeder by 11 airtight connection of wired hose under the suction function of empty feeder 7.
Material in vacuum feeder under gravity, enters dry method pelletizing machine through exit butterfly valve.
Dry method pelletizing machine 8 is installed on the top of hopper mixer 9 in vertical state.Dry method pelletizing machine 8 and hopper mixer 9
12 it is connected with each other by being flexible coupling.The material of dry method pelletizing machine is mixed into material bin through being flexible coupling for lower port under gravity
Conjunction machine.
Mobile platform is integrated together all subsystems of production line, saves big quantity space, and Moving caster is arranged at bottom, pacifies
Dress is put flexibly.All apparatus for production line and its field control layer or its PLC are integrated on a mobile platform, it is to avoid
Wasting time and energy when artificial intervention is needed waits inconvenience.
Claims (2)
1. a kind of pharmacy corporation production process execution system, including local control management level, is connected to the local control
The field control layer and remote monitoring and administration layer of management level；It is characterized in that also including the enterprise for being connected to the remote monitoring and administration layer
Industry management level, which passes through, and the offer in whole product supply chain of the enterprises with medicine of the Direct Communication of system bidirectional is relevant to produce
Conduct for mission critical information also include providing Manufacturing Data Management, plan scheduling management, Production scheduling management, storehouse for enterprise
Deposit management, quality management, human resource management, work centre/equipment control, instrument tool management, purchasing management, cost pipe
The management modules such as reason, project kanban system, production process control, bottom data integrated analysis and the integrated decomposition of upper layer data.
2. pharmacy corporation production process execution system according to claim 1, is characterized in that also including tracking manufacturing schedule, storehouse
Deposit situation, the job schedule flow of information related to the operation management in other turnover workshops.
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| CN201611138187.7A CN106527375A (en) | 2016-12-12 | 2016-12-12 | Production process execution system for pharmaceutical company |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611138187.7A CN106527375A (en) | 2016-12-12 | 2016-12-12 | Production process execution system for pharmaceutical company |
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| CN106527375A true CN106527375A (en) | 2017-03-22 |
Family
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| CN201611138187.7A Withdrawn CN106527375A (en) | 2016-12-12 | 2016-12-12 | Production process execution system for pharmaceutical company |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108227659A (en) * | 2018-01-08 | 2018-06-29 | 中国恩菲工程技术有限公司 | Intelligent waste heat boiler information integration control method |
| CN109884993A (en) * | 2019-01-16 | 2019-06-14 | 上海途么科技有限公司 | A kind of pharmacy digitlization workshop management system |
| CN111402492A (en) * | 2020-03-24 | 2020-07-10 | 安庆咖来菲去物联网科技有限公司 | Automatic vending machine |
| CN112241154A (en) * | 2020-10-15 | 2021-01-19 | 杭州澳亚生物技术有限公司 | Intelligent monitoring management system for GMP workshop |
| CN113721566A (en) * | 2021-08-06 | 2021-11-30 | 苏州长城开发科技有限公司 | Workshop-level multi-closed-loop management system and management method |
-
2016
- 2016-12-12 CN CN201611138187.7A patent/CN106527375A/en not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| 李亚凯等: "制造执行系统在制药行业的应用研究", 《控制工程》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108227659A (en) * | 2018-01-08 | 2018-06-29 | 中国恩菲工程技术有限公司 | Intelligent waste heat boiler information integration control method |
| CN109884993A (en) * | 2019-01-16 | 2019-06-14 | 上海途么科技有限公司 | A kind of pharmacy digitlization workshop management system |
| CN111402492A (en) * | 2020-03-24 | 2020-07-10 | 安庆咖来菲去物联网科技有限公司 | Automatic vending machine |
| CN112241154A (en) * | 2020-10-15 | 2021-01-19 | 杭州澳亚生物技术有限公司 | Intelligent monitoring management system for GMP workshop |
| CN113721566A (en) * | 2021-08-06 | 2021-11-30 | 苏州长城开发科技有限公司 | Workshop-level multi-closed-loop management system and management method |
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