CN106518642A - Emodin extraction process - Google Patents
Emodin extraction process Download PDFInfo
- Publication number
- CN106518642A CN106518642A CN201610845391.6A CN201610845391A CN106518642A CN 106518642 A CN106518642 A CN 106518642A CN 201610845391 A CN201610845391 A CN 201610845391A CN 106518642 A CN106518642 A CN 106518642A
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- CN
- China
- Prior art keywords
- rheum emodin
- extraction process
- process according
- extraction
- rhubarb
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/10—Separation; Purification; Stabilisation; Use of additives
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an emodin extraction process, which comprises: 1, crushing; 2, adjusting the PH value; 3, carrying out ultrasonic treatment; 4, carrying out membrane treatment; 5, extracting; 6, neutralizing; 7, drying; and 8, grinding. According to the present invention, the filtration precision is high, and the purity and the good quality of the filtrate are ensured; the membrane process is the pure physical process and has characteristics of no phase change and low energy consumption, and the system operates at the room temperature so as to overcome the damage of the heat on the active substance in the enzyme preparation product; and compared to the traditional filtration process, the process of the present invention has the following advantages that the quality of the product is improved, and the product yield and the production efficiency are significantly improved.
Description
Technical field
The present invention relates to membrane technology field, particularly a kind of rheum emodin extraction process.
Background technology
Rheum emodin can be used as cathartic, though there is Purgative activity, due to being easily oxidized destruction, actually discharge function very in vivo
It is weak, glycoside is such as combined into sugar, then can play discharge function.Separately there are antibacterial, cough-relieving, antitumor, hypotensive etc. to act on.Modern age faces
Almost each section all uses bed, such as treatment encephalitis B and parotitis, typhoid fever, dysentery, urinary tract infections, gonorrhoea, pneumonia, celluar tissue
Inflammation, suppurative dermatosis, tympanitis, vasculitis etc., and other drugs compatibility treats acute and subacute appendicitis, burn, little
Infantile paralysis numbness, eczema and some fungus-caused skin infections, can treat hepatitis, pinworm, stomatitis, oral lip's ulcer, digestion in addition
Bad, hypertension and artery sclerosis etc., therefore, rheum emodin is clinically using extremely wide.
The existing process production time is long, with the addition of a large amount of virose preservatives and add flocculant in production, and flocculation is got off
Suspended impurity and activated carbon decolorizing absorb the product of part, yield is low；The suspension such as flocculant is removed using plate compression miscellaneous
Matter, production environment are very poor, and production environment is extremely difficult to food additives production requirement；Production intermediate ion is exchanged and macroreticular resin
It is a large amount of to use, expend substantial amounts of water resource and industrial chemicals resource, while a large amount of resins elute poisonous waste water being difficult with life
Change is processed, and brings heavy financial burden and environmental protection pressure to enterprise.
The content of the invention
It is an object of the invention to provide a kind of rheum emodin extraction process.
A kind of rheum emodin extraction process, it is characterised in that extraction process step includes：
Step one, crushing：Roots and stems of rhubarb is crushed, and is put it into；
Step 2, regulation PH：The leachate containing roots and stems of rhubarb will be obtained and be adjusted PH process；
Step 3, ultrasonication：The leachate containing roots and stems of rhubarb after by centrifugal treating is put in ultrasonic treatment unit
Processed again；
Step 4, film process：The zymotic fluid adjusted after PH is put in microfiltration membranes and is processed, obtain rheum emodin solution；
Step 5, extraction：Extractant will be added in the rheum emodin solution for obtaining, obtain rheum emodin precipitation；
Step 6, neutralisation treatment：The rheum emodin for obtaining precipitation is neutralized into PH process to which；
Step 7, drying：The rheum emodin for obtaining precipitation is dried into process；
Step 8, grinding：Dry rheum emodin is ground into crushing, rheum emodin finished product is obtained.
The step one, by wet pulverizing, roots and stems of rhubarb carries out crushing leaching in ethanol solution.
The step 2, is processed by PH regulations, enables the material in the roots and stems of rhubarb of crushing further in ethanol solution
Middle leaching.
The step 3, is delivered in liquid by ultrasonic vibration, excites cavitation effect, a large amount of so as to produce in a liquid
Cavitation bubble, as these cavitation bubbles are produced and explosion, microjet will be produced, entered to be about to the great solid particle of liquid and hit
It is broken, simultaneously because the vibration of ultrasonic wave, makes solid-liquid more fully mix, clasmatosis is made, the extraction of cell inclusion is more
Completely.
The step 4, by organic microfiltration membranes, oarse-grained protein molecule is separated, and the material of membrane component has
Cellulose acetate film (CA) and composite membrane (PA), polyamide sandwich diaphragm, polysulfones (PS) material film, Kynoar (PVDF)
Material film, and modified polyacrylonitrile（PAN）Material film.
The step 5, carries out extraction processing by water.
The step 6, is neutralized process by deionized water.
The step 7, is dried process by Minton dryer.
The step 8, is ground pulverization process by grinder to dry rheum emodin.
Advantages of the present invention：
1st, filtering accuracy is high, fundamentally ensure that the degree of purity of filtrate and the formedness of quality.
2nd, membrane process is pure physical process, and without phase transformation, energy consumption is low, and system is operated at normal temperatures, overcomes heat to enzyme preparation
The destruction of active material in product.
3rd, compare traditional filtering technique, product quality is not only improved, and product yield and production efficiency have compared with
For significant raising.
4th, loss of effective components is reduced, reduces BOD and COD contents in waste water.With traditional filtration, concentration technology method phase
Inorganic salts in technical process, organic solvent can be significantly saved than, new technology, reduce the production cost of product.
5th, the supporting control section advanced design of membranous system, so that the more aobvious simplicity of the operation and maintenance of system, significantly
Reduce the labour intensity of workman.
Description of the drawings
Implementing procedure figure of the accompanying drawing 1 for the present invention.
Specific embodiment
The present invention is further described in detail in conjunction with accompanying drawing 1 and specific embodiment.
Specific embodiment making step is as follows：
A kind of rheum emodin extraction process, it is characterised in that extraction process step includes：
Step one, crushing：Roots and stems of rhubarb is crushed, and is put it into；
Step 2, regulation PH：The leachate containing roots and stems of rhubarb will be obtained and be adjusted PH process；
Step 3, ultrasonication：The leachate containing roots and stems of rhubarb after by centrifugal treating is put in ultrasonic treatment unit
Processed again；
Step 4, film process：The zymotic fluid adjusted after PH is put in microfiltration membranes and is processed, obtain rheum emodin solution；
Step 5, extraction：Extractant will be added in the rheum emodin solution for obtaining, obtain rheum emodin precipitation；
Step 6, neutralisation treatment：The rheum emodin for obtaining precipitation is neutralized into PH process to which；
Step 7, drying：The rheum emodin for obtaining precipitation is dried into process；
Step 8, grinding：Dry rheum emodin is ground into crushing, rheum emodin finished product is obtained.
The present invention specifically shows and describes the present invention with reference to preferred embodiment, it is clear that the present invention is implemented not
Limited by aforesaid way, as long as employing the various unsubstantialities improvement that method of the present invention design and technical scheme are carried out,
Or it is not improved the design of invention and technical scheme are directly applied to into other occasions, protection scope of the present invention it
It is interior..
Claims (9)
1. a kind of rheum emodin extraction process, it is characterised in that extraction process step includes：
Step one, crushing：Roots and stems of rhubarb is crushed, and is put it into；
Step 2, regulation PH：The leachate containing roots and stems of rhubarb will be obtained and be adjusted PH process；
Step 3, ultrasonication：The leachate containing roots and stems of rhubarb after by centrifugal treating is put in ultrasonic treatment unit
Processed again；
Step 4, film process：The zymotic fluid adjusted after PH is put in microfiltration membranes and is processed, obtain rheum emodin solution；
Step 5, extraction：Extractant will be added in the rheum emodin solution for obtaining, obtain rheum emodin precipitation；
Step 6, neutralisation treatment：The rheum emodin for obtaining precipitation is neutralized into PH process to which；
Step 7, drying：The rheum emodin for obtaining precipitation is dried into process；
Step 8, grinding：Dry rheum emodin is ground into crushing, rheum emodin finished product is obtained.
2. a kind of rheum emodin extraction process according to claims 1, it is characterised in that the step one, by wet method
Crush, roots and stems of rhubarb carries out crushing leaching in ethanol solution.
3. a kind of rheum emodin extraction process according to claims 1, it is characterised in that the step 2, is adjusted by PH
Section process, enables the material in the roots and stems of rhubarb of crushing further to leach in ethanol solution.
4. a kind of rheum emodin extraction process according to claims 1, it is characterised in that the step 3, by ultrasound
Vibration is delivered in liquid, excites cavitation effect, so as to produce substantial amounts of cavitation bubble in a liquid, with these cavitation bubbles
Produce and explosion, microjet will be produced, entered to be about to the great solid particle of liquid and smashed, simultaneously because the vibration of ultrasonic wave, makes
Solid-liquid more fully mixes, and makes clasmatosis, and the extraction of cell inclusion is more complete.
5. a kind of rheum emodin extraction process according to claims 1, it is characterised in that the step 4, by organic
Microfiltration membranes, oarse-grained protein molecule is separated, and the material of membrane component has cellulose acetate film (CA) and composite membrane
(PA), polyamide sandwich diaphragm, polysulfones (PS) material film, Kynoar (PVDF) material film, and modified polyacrylonitrile
（PAN）Material film.
6. a kind of rheum emodin extraction process according to claims 1, it is characterised in that the step 5, is entered by water
Row extraction processing.
7. a kind of rheum emodin extraction process according to claims 1, it is characterised in that the step 6, by go from
Sub- water is neutralized process.
8. a kind of rheum emodin extraction process according to claims 1, it is characterised in that the step 7, by vacuum
Drying device is dried process.
9. a kind of rheum emodin extraction process according to claims 1, it is characterised in that the step 8, by grinding
Machine is ground pulverization process to dry rheum emodin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610845391.6A CN106518642A (en) | 2016-09-24 | 2016-09-24 | Emodin extraction process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610845391.6A CN106518642A (en) | 2016-09-24 | 2016-09-24 | Emodin extraction process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106518642A true CN106518642A (en) | 2017-03-22 |
Family
ID=58344239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610845391.6A Pending CN106518642A (en) | 2016-09-24 | 2016-09-24 | Emodin extraction process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106518642A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107337594A (en) * | 2017-08-20 | 2017-11-10 | 合肥信达膜科技有限公司 | A kind of high-purity emodin extracting method |
| CN112782032A (en) * | 2020-12-30 | 2021-05-11 | 华南理工大学 | Method for quickly detecting physical property parameters of raw materials after acidic blasting pretreatment of cellulose and ethanol prepared from wood fiber raw materials and application |
| CN113244791A (en) * | 2021-05-12 | 2021-08-13 | 佳木斯大学 | Phelline-blended phenolphthalein polyethersulfone ultrafiltration membrane and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101698638A (en) * | 2009-10-23 | 2010-04-28 | 中国科学院武汉植物园 | Method for extracting highly purified chrysophanic acid from roots and stems of rhubarb |
| CN101698637A (en) * | 2009-10-23 | 2010-04-28 | 中国科学院武汉植物园 | High-purity emodin separation method |
| CN102010316A (en) * | 2009-09-04 | 2011-04-13 | 中国药科大学 | Method for extracting high-purity frangula emodin from polygonum cuspidatum |
| CN105906493A (en) * | 2016-04-29 | 2016-08-31 | 苏州市天灵中药饮片有限公司 | Extraction process of emodin |
-
2016
- 2016-09-24 CN CN201610845391.6A patent/CN106518642A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102010316A (en) * | 2009-09-04 | 2011-04-13 | 中国药科大学 | Method for extracting high-purity frangula emodin from polygonum cuspidatum |
| CN101698638A (en) * | 2009-10-23 | 2010-04-28 | 中国科学院武汉植物园 | Method for extracting highly purified chrysophanic acid from roots and stems of rhubarb |
| CN101698637A (en) * | 2009-10-23 | 2010-04-28 | 中国科学院武汉植物园 | High-purity emodin separation method |
| CN105906493A (en) * | 2016-04-29 | 2016-08-31 | 苏州市天灵中药饮片有限公司 | Extraction process of emodin |
Non-Patent Citations (1)
| Title |
|---|
| 朱庆玲等: "大黄中大黄素的提取工艺研究", 《时珍国医国药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107337594A (en) * | 2017-08-20 | 2017-11-10 | 合肥信达膜科技有限公司 | A kind of high-purity emodin extracting method |
| CN112782032A (en) * | 2020-12-30 | 2021-05-11 | 华南理工大学 | Method for quickly detecting physical property parameters of raw materials after acidic blasting pretreatment of cellulose and ethanol prepared from wood fiber raw materials and application |
| CN113244791A (en) * | 2021-05-12 | 2021-08-13 | 佳木斯大学 | Phelline-blended phenolphthalein polyethersulfone ultrafiltration membrane and preparation method thereof |
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Application publication date: 20170322 |