CN107337594A - A kind of high-purity emodin extracting method - Google Patents
A kind of high-purity emodin extracting method Download PDFInfo
- Publication number
- CN107337594A CN107337594A CN201710715746.4A CN201710715746A CN107337594A CN 107337594 A CN107337594 A CN 107337594A CN 201710715746 A CN201710715746 A CN 201710715746A CN 107337594 A CN107337594 A CN 107337594A
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- CN
- China
- Prior art keywords
- emodin
- rheum emodin
- processing
- rhubarb
- stems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/10—Separation; Purification; Stabilisation; Use of additives
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of high-purity emodin extracting method, extraction process step includes：Step 1: crush；Step 2: regulation PH；Step 3: ultrasonication；Step 4: film process；Step 5: extraction；Step 6: neutralisation treatment；Step 7: dry；Step 8: grinding, filtering accuracy of the present invention is high.It fundamentally ensure that the degree of purity of filtrate and the formedness of quality；Membrane process is pure physical process, and no phase transformation, energy consumption is low, and system operates at normal temperatures, overcomes destruction of the heat to active material in enzyme preparation product；Compared to traditional filtering technique, product quality is not only improved, and product yield and production efficiency have more significant raising.
Description
Technical field
The present invention relates to membrane technology field, particularly a kind of high-purity emodin extracting method.
Background technology
Rheum emodin can be used as cathartic, though there is Purgative activity, due to being easily oxidized destruction, actually discharge function very in vivo
It is weak, glycoside is such as combined into sugar, then can play discharge function.It is another to have the effect such as antibacterial, cough-relieving, antitumor, hypotensive.Modern age faces
Almost each section all uses bed, such as treats encephalitis B and parotitis, typhoid fever, dysentery, urinary tract infections, gonorrhoea, pneumonia, celluar tissue
Inflammation, suppurative dermatosis, tympanitis, vasculitis etc., and other drugs compatibility treat acute and subacute appendicitis, burn, small
Infantile paralysis numbness, eczema and some fungus-caused skin infections, can treat hepatitis, pinworm, stomatitis, oral lip's ulcer, digestion in addition
Bad, hypertension and artery sclerosis etc., therefore, rheum emodin is clinically using extremely wide.
The existing process production time is grown, and a large amount of virose preservative addition flocculants are with the addition of in production, and flocculation is got off
Suspended impurity and activated carbon decolorizing absorb the product of part, yield is low；It is miscellaneous that the suspension such as flocculant is removed using plate compression
Matter, production environment is very poor, and production environment is extremely difficult to food additives production requirement；Intermediate ion is produced to exchange and macroreticular resin
It is a large amount of to use, expend substantial amounts of water resource and industrial chemicals resource, while it is difficult with life that a large amount of resins, which elute poisonous waste water,
Change is handled, and heavy financial burden and environmental protection pressure are brought to enterprise.
The content of the invention
It is an object of the invention to provide a kind of high-purity emodin extracting method.
A kind of high-purity emodin extracting method, specific steps include：
Step 1: crush：Roots and stems of rhubarb is crushed, and puts it among ethanol and is leached；
Step 2: regulation PH：The leachate containing roots and stems of rhubarb will be obtained PH processing is adjusted；
Step 3: ultrasonication：The leachate containing roots and stems of rhubarb after centrifugal treating is put into ultrasonic treatment unit
Handled again；
Step 4: film process：Zymotic fluid after regulation PH is put into microfiltration membranes and handled, obtains rheum emodin solution；
Step 5: extraction：Extractant will be added in obtained rheum emodin solution, obtain rheum emodin precipitation；
Step 6: neutralisation treatment：Obtained rheum emodin precipitation is carried out neutralizing PH processing to it；
Step 7: dry：Processing is dried in obtained rheum emodin precipitation；
Step 8: grinding：Dry rheum emodin is ground crushing, obtains rheum emodin finished product.
The step 1, by wet pulverizing, roots and stems of rhubarb carries out crushing leaching in ethanol solution.
The step 2, handled by PH regulations, enable the material in the roots and stems of rhubarb of crushing further in ethanol solution
Middle leaching.
The step 3, is delivered in liquid by ultrasonic vibration, excites cavitation effect, a large amount of so as to produce in a liquid
Cavitation bubble, with these cavitation bubbles produce and explosion, microjet will be produced, enters to be about to the great solid particle of liquid and hit
It is broken, simultaneously because the vibration of ultrasonic wave, makes solid-liquid more fully mix, make clasmatosis, the extraction of cell inclusion is more
Completely.
The step 4, by organic microfiltration membranes, the protein molecule of bulky grain is separated, the material of membrane component has
Cellulose acetate film (CA) and composite membrane (PA), polyamide sandwich diaphragm, polysulfones (PS) material film, Kynoar (PVDF)
Material film, and modified polyacrylonitrile（PAN）Material film.
The step 5, extraction processing is carried out by water.
The step 6, neutralisation treatment is carried out by deionized water.
The step 7, processing is dried by Minton dryer.
The step 8, pulverization process is ground to dry rheum emodin by grinder.
The high-purity emodin extracting method of the present invention has the following advantages：
1st, filtering accuracy is high, fundamentally ensure that the degree of purity of filtrate and the formedness of quality.
2nd, membrane process is pure physical process, and no phase transformation, energy consumption is low, and system operates at normal temperatures, overcomes heat to enzyme preparation
The destruction of active material in product.
3rd, be not only improved compared to traditional filtering technique, product quality, and product yield and production efficiency have compared with
Improved to be significant.
4th, loss of effective components is reduced, reduces BOD and COD contents in waste water.With traditional filtering, concentration technology method phase
Than new technology can significantly save inorganic salts, organic solvent in technical process, reduce the production cost of product.
5th, the supporting control section advanced design of membranous system, so that the more aobvious simplicity of the operation and maintenance of system, significantly
Reduce the labor intensity of worker.
Brief description of the drawings
Accompanying drawing 1 is the implementing procedure figure of high-purity emodin extracting method of the present invention.
Specific embodiment
The present invention is further described in detail in conjunction with accompanying drawing 1 and specific embodiment.
Specific embodiment making step is as follows：
A kind of high-purity emodin extracting method, specific steps include：
Step 1: crush：Roots and stems of rhubarb is crushed, and puts it among ethanol and is leached；
Step 2: regulation PH：The leachate containing roots and stems of rhubarb will be obtained PH processing is adjusted；
Step 3: ultrasonication：The leachate containing roots and stems of rhubarb after centrifugal treating is put into ultrasonic treatment unit
Handled again；
Step 4: film process：Zymotic fluid after regulation PH is put into microfiltration membranes and handled, obtains rheum emodin solution；
Step 5: extraction：Extractant will be added in obtained rheum emodin solution, obtain rheum emodin precipitation；
Step 6: neutralisation treatment：Obtained rheum emodin precipitation is carried out neutralizing PH processing to it；
Step 7: dry：Processing is dried in obtained rheum emodin precipitation；
Step 8: grinding：Dry rheum emodin is ground crushing, obtains rheum emodin finished product.
The present invention specifically shows and described the present invention with reference to preferred embodiment, it is clear that present invention specific implementation is not
Limited by aforesaid way, as long as the various unsubstantialities for employing inventive concept and technical scheme of the present invention progress improve,
Or it is not improved the design of invention and technical scheme are directly applied into other occasions, protection scope of the present invention it
It is interior.
Claims (2)
1. a kind of high-purity emodin extracting method, it is characterised in that specific steps include：
Step 1: crush：Roots and stems of rhubarb is crushed, and puts it among ethanol and is leached；By wet pulverizing, greatly
Xanthorrhiza stem carries out crushing leaching in ethanol solution；
Step 2: regulation PH：The leachate containing roots and stems of rhubarb will be obtained PH processing is adjusted；Handled, made by PH regulations
Material in the roots and stems of rhubarb of crushing can be leached further in ethanol solution；
Step 3: ultrasonication：The leachate containing roots and stems of rhubarb after centrifugal treating is put into ultrasonic treatment unit
Handled again；
Step 4: film process：Zymotic fluid after regulation PH is put into microfiltration membranes and handled, obtains rheum emodin solution；Pass through
Organic microfiltration membranes, the protein molecule of bulky grain is separated, the material of membrane component has cellulose acetate film and composite membrane, polyamides
Amine sandwich diaphragm, polysulfones material film, Kynoar material film, and modified polyacrylonitrile material film；
Step 5: extraction：Extractant will be added in obtained rheum emodin solution, obtain rheum emodin precipitation；Extracted by water
Processing；
Step 6: neutralisation treatment：Obtained rheum emodin precipitation is carried out neutralizing PH processing to it；Neutralized by deionized water
Processing；
Step 7: dry：Processing is dried in obtained rheum emodin precipitation；Processing is dried by Minton dryer；
Step 8: grinding：Dry rheum emodin is ground crushing, obtains rheum emodin finished product；By grinder to dry
Rheum emodin is ground pulverization process.
2. a kind of high-purity emodin extracting method according to claim 1, it is characterised in that the step 3, pass through
Ultrasonic vibration is delivered in liquid, excites cavitation effect, so as to produce substantial amounts of cavitation bubble in a liquid, with these cavitations
Bubble produces and explosion, will produce microjet, enters to be about to the great solid particle of liquid and smash, simultaneously because ultrasonic wave shakes
It is dynamic, solid-liquid is more fully mixed, make clasmatosis, the extraction of cell inclusion is more complete.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710715746.4A CN107337594A (en) | 2017-08-20 | 2017-08-20 | A kind of high-purity emodin extracting method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710715746.4A CN107337594A (en) | 2017-08-20 | 2017-08-20 | A kind of high-purity emodin extracting method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107337594A true CN107337594A (en) | 2017-11-10 |
Family
ID=60214225
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710715746.4A Pending CN107337594A (en) | 2017-08-20 | 2017-08-20 | A kind of high-purity emodin extracting method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113244791A (en) * | 2021-05-12 | 2021-08-13 | 佳木斯大学 | Phelline-blended phenolphthalein polyethersulfone ultrafiltration membrane and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101698637A (en) * | 2009-10-23 | 2010-04-28 | 中国科学院武汉植物园 | High-purity emodin separation method |
| CN105906493A (en) * | 2016-04-29 | 2016-08-31 | 苏州市天灵中药饮片有限公司 | Extraction process of emodin |
| CN106518642A (en) * | 2016-09-24 | 2017-03-22 | 合肥信达膜科技有限公司 | Emodin extraction process |
-
2017
- 2017-08-20 CN CN201710715746.4A patent/CN107337594A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101698637A (en) * | 2009-10-23 | 2010-04-28 | 中国科学院武汉植物园 | High-purity emodin separation method |
| CN105906493A (en) * | 2016-04-29 | 2016-08-31 | 苏州市天灵中药饮片有限公司 | Extraction process of emodin |
| CN106518642A (en) * | 2016-09-24 | 2017-03-22 | 合肥信达膜科技有限公司 | Emodin extraction process |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113244791A (en) * | 2021-05-12 | 2021-08-13 | 佳木斯大学 | Phelline-blended phenolphthalein polyethersulfone ultrafiltration membrane and preparation method thereof |
| CN113244791B (en) * | 2021-05-12 | 2022-06-17 | 佳木斯大学 | Preparation method of emodin-blended phenolphthalein polyethersulfone ultrafiltration membrane |
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| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171110 |