CN106511927A - Navel patch for treating infant enteritis and preparation method thereof - Google Patents

Navel patch for treating infant enteritis and preparation method thereof Download PDF

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Publication number
CN106511927A
CN106511927A CN201611020097.8A CN201611020097A CN106511927A CN 106511927 A CN106511927 A CN 106511927A CN 201611020097 A CN201611020097 A CN 201611020097A CN 106511927 A CN106511927 A CN 106511927A
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Prior art keywords
navel
enteritis
preparation
medicine
infant
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CN201611020097.8A
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李化兵
杨增金
李臣芳
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms

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Abstract

The invention discloses a navel patch for treating infant enteritis and a preparation method thereof. The navel patch is prepared from, by weight, 1 cortex phellodendri capsule with the weight of 1 g, 1 ampoule bottle of anisodamine injection with the concentration of 10 mg/1 ml and 1 musk bone-strengthening plaster. The preparation method includes the steps that 1, inner granules in the cortex phellodendri capsule with the weight of 1 g are taken out and added into 5 mg of anisodamine injection, and the mixture is stirred evenly into a pasty state; 2, the pasty fluid obtained in the step 1 is put in the navel fossa of a sick infant, and the musk bone-strengthening plaster is pasted on the navel to fix the pasty medicine and is removed after the state lasts for 3-5 hours. For treatment of infant infective enteritis, the advanced technology of directly putting the pasty medicine in the navel fossa is adopted, the absorption effect of the navel patch is better than that of a gauze navel patch, permeation of medicine and medicine absorption of the human body are promoted, and thus navel medication can play a role which oral medicine can not play; besides, all medicinal materials of the navel patch are conventionally available for purchase and are easy to obtain; moreover, the preparation method is simple and easy to implement, a user can conveniently prepare the navel patch at home, and a good method is provided for treating infant enteritis.

Description

It is a kind of to treat navel paster of infantile enteritis and preparation method thereof
Technical field
The present invention relates to field of medical technology, specially a kind of to treat navel paster of infantile enteritis and preparation method thereof.
Background technology
Infantile enteritis are a kind of common digestive system disease, and cardinal symptom is to suffer from diarrhoea, suffer from abdominal pain, with or the heat that do not occur together, Vomiting etc., is the big reason for causing infantile nutrition bad with dysplasia.
The main method for the treatment of infantile enteritis includes oral anti-inflammatory drug, probiotic bacteria, fluid infusion salt, mucosa protective agent at present Infant Deng, middle severe dehydration may also need to correct dehydration of infusing.But these method major part infant compliances are poor, or even Certain pain is produced to the head of a family and child in therapeutic process.For the difficult phenomenon of oral drugs, some producers are proposed difference The navel paster of brand.Medicine in umbilicuss patch is absorbed by the body through umbilical part, and different medicines plays different effects, clinical at present The Main Function of the navel paster of upper application is to adjust the intestinal microbial population of infant, emesis, aid digestion, warm abdomen etc..
The main component of the navel paster clinically applied includes Flos Caryophylli, Cortex Cinnamomi, Fructus Piperis Longi, Fructus Piperiss, Fructus Evodiae, Rhizoma Atractylodis, wood Perfume, Fructus Zanthoxyli, Fructus Foeniculi, Rhizoma Zingiberiss etc., adjuvant are vaseline, laurocapram, glycerol, paraffin, lanoline etc., are fixed on gauze On.Effect is spleen invigorating warming middle-JIAO, cold expelling antidiarrheal, adjusts the intestinal microbial population of infant, emesis, aid digestion, warm abdomen etc., and this kind of navel paster is few There are antiinflammatory, pain relieving, little is acted on to infectious diarrhea, is mainly used in gastrointestinal dysfunction, alteration of intestinal flora etc. non- The treatment of infective enteritiss.And all it is the mode for employing fixed drug in gauze patch, it is little with the laminating degree of umbilical part, through umbilicuss The absorption in portion is incomplete, in its meaning auxiliary treatment still as oral drugs and intravenous pharmacy, it is impossible to alone as baby children The principal agent of youngster's enteritis.
The content of the invention
It is an object of the invention to provide a kind of treat navel paster of infantile enteritis and preparation method thereof, it is straight using mass Omphalos advanced technology is accessed, absorption is posted compared with gauze class umbilicuss, is conducive to the absorption of the infiltration and human body of medicine to medicine, therefore umbilicuss Portion's medication can be played a part of oral drugs and not have, and the various medical materials of umbilicuss of the present invention patch are routinely on sale, obtain easy, And manufacture method is simple, voluntarily prepare in being easy to family, to solve the problems, such as to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme：A kind of navel paster for treating infantile enteritis, including The raw material of following parts by weight proportioning：1 piece of the Cortex Phellodendri capsule of 1g, the Anisodamine injection 1 of 10mg/1ml and bone-strengthening musk Cream 1 is pasted.
Preferably, it is graininess in the Cortex Phellodendri capsule, is made up of one medical material of Cortex Phellodendri, the main component of said preparation is little Bark of a cork tree alkali, jateorhizine, magnoflorine, phellodendrine, obacunone, obakulactone and Dictamnolide, its pharmacological action are disease-resistant former micro- life Thing effect, antiinflammatory action, treatment ulcer function and immunosuppressive action.
Preferably, the Anisodamine injection is that M- cholinoceptors blocker is liquid into what is be grouped into, and its pharmacology is made With for release smooth muscle spasm, alleviate vasospasm, suppress enteraden secretion, reduce enterokinesia, protect gastrointestinal mucosa, improve intestinal Spasm and the microcirculatory effect of improvement.
Preferably, the SHEXIANG ZHUANGGU GAO is finished product medical material, and the pharmacological action of its Moschus is antiinflammatory, kills the effect of " gluing ".
The invention solves the problems that another technical problem be to provide a kind of preparation method of the navel paster for treating infantile enteritis, Comprise the following steps：
S1：Endoparticle in 1 piece of Cortex Phellodendri capsule for 1g is taken out, is added in the Anisodamine injection of 5mg, and is stirred Mix and mix well to pasty state；
S2：Pasty fluid in S1 is placed in infant omphalos, and 1 patch SHEXIANG ZHUANGGU GAO is attached on umbilicuss for fixing Pasty medicament, takes off after continuing 3-5 hours, adheres to 1 day 1-2 time.
Compared with prior art, the invention has the beneficial effects as follows：
1st, navel paster of the treatment infantile enteritis and preparation method thereof, in the treatment of infant infection enteritis, Using the medicine for having antiinflammation, mass is directly entered omphalos, advanced technology, absorption are posted compared with gauze class umbilicuss, and can be led to The mode for crossing umbilicuss patch plays a role.
2nd, navel paster of the treatment infantile enteritis and preparation method thereof is more with abdomen for infant infection enteritis By the osmosiss of medicine, the symptom of pain, the present invention solve the problems, such as that infant is suffered from abdominal pain, the pain of mitigation infant, while and can be with Avoid the difficulty of oral drugs；And, for the problem of the absorption rate of medicine, the present invention has abandoned traditional umbilicuss patch can not be very The shortcoming of laminating omphalos, enters omphalos using medicine well, and good absorbing, its manufacture method are simple, and material is convenient desirable, is treatment baby The good method of child's enteritis.
Specific embodiment
Technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described enforcement Example is only a part of embodiment of the invention, rather than the embodiment of whole.Based on the embodiment in the present invention, this area is common The every other embodiment obtained under the premise of creative work is not made by technical staff, belongs to the model of present invention protection Enclose.
The present invention provides a kind of technical scheme：A kind of navel paster for treating infantile enteritis, including following parts by weight match somebody with somebody The raw material of ratio：1 piece of the Cortex Phellodendri capsule of 1g, the Anisodamine injection 1 of 10mg/1ml and SHEXIANG ZHUANGGU GAO 1 are pasted；Wherein, Cortex Phellodendri It is graininess in capsule, is made up of one medical material of Cortex Phellodendri, the main component of said preparation is berberine, jateorhizine, magnoflorine, Huang The alkaloids such as cypress alkali, also include obacunone, obakulactone and Dictamnolide etc., and the pharmacological action which has is disease-resistant former micro- life Thing effect, antiinflammatory action, treatment ulcer function and immunosuppressive action, are natural antibacterials, can be direct through skin Play a role, treat infantile enteritis；Secondly, Anisodamine injection is M- cholinoceptors blocker into the liquid being grouped into Shape, its pharmacological action are secreted, reduce enterokinesia to release smooth muscle spasm, alleviating vasospasm, suppression enteraden, while protecting stomach Intestinal mucosa, improve intestinal cramps and improve microcirculatory effect, absorbing transmission from skin effect is good, can be obviously improved infant intestinal The stomachache of inflammation, symptom of diarrhea；In addition, the finished product medical material that SHEXIANG ZHUANGGU GAO is common pharmacy peddles, the pharmacological action of its Moschus is Antiinflammatory, the effect for killing " gluing ", can absorb in abdomen from umbilical part rapidly, play antiinflammation.
In actual use, a kind of preparation method of the navel paster for treating infantile enteritis, comprises the following steps：
S1：Endoparticle in 1 piece of Cortex Phellodendri capsule for 1g is taken out, is added in the Anisodamine injection of 5mg, and is stirred Mix and mix well to pasty state, in case the use of subsequent step；
S2：Pasty fluid in S1 is placed in infant omphalos, and 1 patch SHEXIANG ZHUANGGU GAO is attached on umbilicuss for fixing Pasty medicament, takes off after continuing 3-5 hours, adheres to 1 day 1-2 time.
Which adopts mass directly to enter omphalos advanced technology, and absorption is posted compared with gauze class umbilicuss, and umbilical part is abdominal part after people's birth The position of last closure, umbilicus horny layer is most thin, and barrier ability is most weak, umbilicuss week rich blood vessel, be conducive to oozing for medicine Thoroughly and absorption of the human body to medicine, therefore umbilical part medication can be played a part of oral drugs and not have；And, umbilicuss patch of the present invention Various medical materials are routinely on sale, obtain easy, and manufacture method is simple, voluntarily prepares in being easy to family.
In sum：Navel paster of this treatment infantile enteritis and preparation method thereof, for infant infection enteritis In treatment, using the medicine for having antiinflammation, and can play a role by way of umbilicuss are pasted；For infant infection intestinal Scorching many symptoms with stomachache, the present invention pass through the osmosiss of medicine and solve the problems, such as that infant is suffered from abdominal pain, and mitigate the pain of infant, The difficulty of oral drugs can be avoided simultaneously again；And, for the problem of the absorption rate of medicine, the present invention has abandoned tradition Umbilicuss paste the shortcoming of omphalos of can not fitting very well, enter omphalos using medicine, and good absorbing, its manufacture method are simple, and material is convenient can Take, be the good method for treating infantile enteritis.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with Understanding can carry out various changes, modification, replacement to these embodiments without departing from the principles and spirit of the present invention And modification, the scope of the present invention be defined by the appended.

Claims (5)

1. a kind of navel paster for treating infantile enteritis, it is characterised in that including the raw material of following parts by weight proportioning：The Huang of 1g 1 piece of cypress capsule, the Anisodamine injection 1 of 10mg/1ml and SHEXIANG ZHUANGGU GAO 1 are pasted.
2. a kind of navel paster for treating infantile enteritis according to claim 1, it is characterised in that in the Cortex Phellodendri capsule For graininess, be made up of one medical material of Cortex Phellodendri, the main component of said preparation be berberine, jateorhizine, magnoflorine, phellodendrine, Obacunone, obakulactone and Dictamnolide, its pharmacological action are resisting pathogenic microbes effect, antiinflammatory action, treatment ulcer function And immunosuppressive action.
3. a kind of navel paster for treating infantile enteritis according to claim 1, it is characterised in that the Anisodamine note It is liquid into what is be grouped into for M- cholinoceptors blocker to penetrate liquid, and its pharmacological action is releasing smooth muscle spasm, alleviates blood vessel convulsion Contraction, suppression enteraden are secreted, reduce enterokinesia, protect gastrointestinal mucosa, improve intestinal cramps and improve microcirculatory effect.
4. a kind of navel paster for treating infantile enteritis according to claim 1, it is characterised in that the SHEXIANG ZHUANGGU GAO For finished product medical material, the pharmacological action of its Moschus is antiinflammatory, kills the effect of " gluing ".
5. a kind of preparation method of the navel paster for treating infantile enteritis, it is characterised in that comprise the following steps：
S1：Endoparticle in 1 piece of Cortex Phellodendri capsule for 1g is taken out, is added in the Anisodamine injection of 5mg, and is stirred tune It is even to pasty state；
S2：Pasty fluid in S1 is placed in infant omphalos, and 1 patch SHEXIANG ZHUANGGU GAO is attached on umbilicuss for fixing pasty state Medicine, takes off after continuing 3-5 hours, adheres to 1 day 1-2 time.
CN201611020097.8A 2016-11-21 2016-11-21 Navel patch for treating infant enteritis and preparation method thereof Pending CN106511927A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108498488A (en) * 2018-04-25 2018-09-07 无锡市儿童医院 It is a kind of to prepare the method for applying navel patch and its deposited navel patch of rheum officinale using rheum officinale

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ASKV56P6: "我家宝宝从三个月就开始拉肚子，吃了一段", 《HTTP://ASK.39.NET/QUESTION/26701826.HTML》 *
蔡向红: "《单方验方保健说明书》", 30 June 2014, 陕西科学技术出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108498488A (en) * 2018-04-25 2018-09-07 无锡市儿童医院 It is a kind of to prepare the method for applying navel patch and its deposited navel patch of rheum officinale using rheum officinale

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Application publication date: 20170322