CN106510618A - Optrode-electrode configuration method used for whole-brain photoelectric synchronous cerebral function imaging - Google Patents
Optrode-electrode configuration method used for whole-brain photoelectric synchronous cerebral function imaging Download PDFInfo
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- 210000004556 brain Anatomy 0.000 claims description 27
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- 210000003128 head Anatomy 0.000 claims description 5
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- 210000003792 cranial nerve Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
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- 210000005036 nerve Anatomy 0.000 description 2
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- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 108010002255 deoxyhemoglobin Proteins 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
- 230000007831 electrophysiology Effects 0.000 description 1
- 238000002001 electrophysiology Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
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- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
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- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
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- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
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Abstract
The invention belongs to the field of medical apparatus and instruments, and in particular relates to an optrode-electrode configuration method used for whole-brain photoelectric synchronous cerebral function imaging, aiming at solving the problems that the existing optrode-electrode configuration method is small in detection range and inaccurate in locating. The optrode-electrode configuration method used for whole-brain photoelectric synchronous cerebral function imaging comprises the following steps: selecting the positions of the electrodes; placing the electrodes; placing the optrodes; and adjusting the positions of the optrodes. According to the optrode-electrode configuration method, the electrodes are arranged following the international universal '10-20' positioning system criterion, the light source electrodes and the optical detection electrodes are symmetrically distributed on two sides of the electrodes, the distances between the electrodes and the optrodes are limited, and the angles between the electrodes and the optrodes are adjusted, so that while the optrodes and the electrodes are accurately located, the photoelectric synchronous detection within the whole-brain range can be realized, and moreover, the multiplexing among the optrodes achieves the maximum.
Description
Technical field
The invention belongs to medical instruments field, specifically provide a kind of auroral poles for full brain photoelectric synchronous cerebral function imaging-
Electrode arrangements method.
Background technology
Cerebration includes multiple processes such as neuron activity and local energetic supersession.Researcher is by observing various moulds
The cerebration signal of state is explored to brain function, wherein most it is representational be neuron electrical activity and local blood oxygen metabolism
The information of change both modalities which.Since nearly half a century, the research based on single modal information in a large number has deeply promoted people
Understanding to brain function.But as the different angles of cerebration, the effective integration to different modalities information is only realized,
Cerebration could organically be connected.At present Electrophysiology equipment and metabolic process testing equipment are combined, is filled
Divide the advantage using both, have become depth finding and understand the important channel of nerve information.
Photoelectric synchronous cerebral function imaging is a kind of to research and develop, it is intended to by by near infrared spectrum cerebral function imaging technology
With the effective integration of brain wave acquisition technology, near infrared spectrometer, electroencephalograph and near infrared spectrum and brain is realized on same instrument
The technology of three function integrations of electro' asion instrument.It is capable of achieving synchronous acquisition of brain area nerve electrical activity and blood oxygen supply information etc.
Several functions, will be the important imaging techniques of control fusion cranial nerve electrical activity and blood oxygen activity.
At present, although the brain electricity of existing some research and utilization independences and near infrared imaging system, by the electrode in brain electricity with
The simple cross arrangement of auroral poles near infrared imaging is realized photoelectric synchronous cerebral function imaging, but these is studied in a certain brain area
Using arrangement mode there is a problem of that some can not be ignored.First, great majority research is in office according to specific requirement of experiment
The specificity arrangement that portion's brain area is carried out, its arrangement mode cannot be generalized to the observation of other brain areas, cannot also be generalized to other realities
Repeatability between the research tested under purpose, and different experiments room is poor, is unfavorable for the repeatability checking to result of study.Its
Secondary, the arrangement of most of auroral poles-electrodes is attached using stator, but due to the restriction of regular length so that electrode for encephalograms
Arrangement position can not meet the positioning principle of brain wave acquisition, have impact on the contrast verification of result and tradition research.
Correspondingly, this area needs a kind of new auroral poles-electrode arrangements method to solve the above problems.
The content of the invention
In order to solve the problems referred to above of the prior art, the existing auroral poles of solution-electrode arrangements method detection range has been
Little, the inaccurate problem of positioning, the invention provides a kind of auroral poles-electrode arrangements for full brain photoelectric synchronous cerebral function imaging
Method, the method comprise the steps：The criterion for following international " 10-20 " alignment system chooses multiple photoelectric synchronous inspections
Survey electrode position；Electrode is positioned on selected photoelectric synchronous detecting electrode position；Auroral poles is positioned over into the both sides of electrode.
In the optimal technical scheme of above-mentioned arrangement method, the placed angle of auroral poles is adjusted, with answering for achievement unit light splitting pole
With.
In the optimal technical scheme of above-mentioned arrangement method, " 10-20 " alignment system refer to people's scalp surface with
Nose between two is recessed, rear side occipital protuberance, both sides mastoid process are reference point, along around, the orientation measurement scalp table such as head circumference
Face, and the coordinate system of the locus of scalp surface is marked according to special ratios.
In the optimal technical scheme of above-mentioned arrangement method, the auroral poles is included for sending the light source electrode of light source and being used for
The light detection pole of light source is received, the smooth source electrode is collectively forming light sense channel with light detection pole.
In the optimal technical scheme of above-mentioned arrangement method, the smooth source electrode is symmetrically arranged at institute with light detection pole
State the both sides of electrode.
In the optimal technical scheme of above-mentioned arrangement method, with the light, the smooth source electrode detects that centre-to-centre spacing L of pole is
2.5cm≤L≤4cm。
In the optimal technical scheme of above-mentioned arrangement method, the standard for following international " 10-20 " alignment system
The step of then choosing multiple photoelectric synchronous detecting electrode positions further includes：Follow international " 10-20 " alignment system
Criterion choose 32 photoelectric synchronous detecting electrode positions.
In the optimal technical scheme of above-mentioned arrangement method, the auroral poles detection is carried out based near infrared spectrum imaging, its
Wavelength is between 650～950nm.
In the optimal technical scheme of above-mentioned arrangement method, the auroral poles multiplexing refers to two or more auroral poles sense channels
Between share the same smooth source electrode or the light detection pole.
It will be appreciated to those of skill in the art that in the preferred technical solution of the present invention, it is international by following
" 10-20 " alignment system criterion arrange the electrode, the smooth source electrode and light detection pole are symmetrically arranged in it is described
Electrode both sides simultaneously limit the distance between the two, adjust the mode of the placed angle of the two so that the auroral poles is fixed with the electrode
While level is true, also may be implemented in, and the smooth interpolar is maximized and realized again
With.
Description of the drawings
Fig. 1 is the flow chart of the auroral poles for the full brain photoelectric synchronous cerebral function imaging-electrode arrangements method of the present invention；
Fig. 2A is the side view of the electrode arrangements of international " 10-20 " alignment system；
Fig. 2 B are the top views of the electrode arrangements of international " 10-20 " alignment system；
Fig. 3 is the schematic diagram of the electrode for encephalograms position that basis " 10-20 " alignment system of the present invention is selected；
Fig. 4 is propagation path schematic diagram of the near infrared light of the present invention in cerebral tissue；
Fig. 5 is the schematic diagram of the auroral poles-electrode arrangements for full brain photoelectric synchronous cerebral function imaging of the present invention；
Fig. 6 is showing for the auroral poles-electrode arrangements after the auroral poles of the present invention is multiplexed for full brain photoelectric synchronous cerebral function imaging
It is intended to.
Specific embodiment
With reference to the accompanying drawings describing the preferred embodiment of the present invention.It will be apparent to a skilled person that this
A little embodiments are used only for explaining the know-why of the present invention, it is not intended that limit the scope of the invention.For example, although
The detailed step of the inventive method is described in detail below, but, on the premise of the general principle without departing from the present invention, ability
Field technique personnel can be combined to above-mentioned steps, split and reversed order, and so amended technical scheme does not change
Become the basic conception of the present invention, therefore also fall within protection scope of the present invention.
As shown in Figures 1 to 6, the auroral poles for full brain photoelectric synchronous cerebral function imaging-electrode arrangements method of the invention is opened
Start from S10 steps.In step slo, choose the position of electrode 11：Specifically, it then follows international " 10-20 " alignment system
Criterion choose multiple photoelectric synchronous detecting electrode positions.It should be noted that (with reference to Fig. 2A, Fig. 2 B), " 10-20 " positioning system
System refers to that nose recessed (nasion) between people's scalp surface is with two, rear side occipital protuberance (inion), both sides mastoid process are (front
Auriculare) it is reference point, along around, the orientation measurement scalp surface such as head circumference, and head is marked according to 10%, 20% equal proportion
The coordinate system of the locus in epidermis face.Preferably, the present invention selects the more uniform 32 conventional seats of locus distribution
Punctuate is used as photoelectric synchronous sense channel position, the i.e. position of electrode 11.With reference to shown in Fig. 3, these positions are specially：Fp1,
Fp2, AF3, AF4, F7, F8, F3, F4, Fz, FC5, FC6, FC1, FC2, T7, T6, C3, C4, Cz, CP5, CP6, CP1, CP2, P7,
P8, P3, P4, Pz, PO3, PO4, O1, O2, Oz.According to order from front to back, from left to right, to as above channel number it is respectively
Ci, i=1,2,3...32.
As shown in Fig. 3, Fig. 5, next, in step S20, placing electrode：Specifically, electrode 11 is positioned over selected
On photoelectric synchronous detecting electrode position, electro-detection passage (not marking in figure) is formed.It will be appreciated to those of skill in the art that
As it was previously stated, after electrode 11 is placed on selected coordinate points, the position of these electrodes 11 meets international " 10-20 " positioning
System criterion.
Again, as shown in Figure 4, Figure 5, in step s 30, place auroral poles：Specifically, auroral poles is positioned over the two of electrode 11
Side.The point centered on 32 11 positions of electrode for placing, is symmetrically positioned one for sending light source in the both sides of electrode 11
Light source electrode 12 and the light for receiving light source detect pole 13, centre-to-centre spacing L of the two is 2.5cm≤L≤4cm, now light source electrode
Light sense channel 14 can be formed between 12 and light detection pole 13, light sense channel 14 together form photoelectricity with electro-detection passage
Synchronous sense channel.Preferably, with light, light source electrode 12 detects that centre-to-centre spacing L of pole 13 is optimal at 3cm or so.
It will be appreciated to those of skill in the art that when photoelectric synchronous cerebral function imaging is carried out, electrode 11 receives brain
The electromagnetic wave that cranial nerve electrical activity is produced；Near infrared light, is preferably chosen the light wave that wavelength is 650～950nm, by light source electrode
12 Jing scalp surfaces incide cerebral tissue, through absorption and each tissue of the materials such as hemoglobin, deoxyhemoglobin
The scattering of cell, forms the light sense channel 14 of " banana-shaped ", is projected by scalp surface and is detected reception by light detection pole 13.
As shown in fig. 6, it is last, in step s 40, adjustment auroral poles position：Specifically, the placed angle of auroral poles is adjusted, with
The multiplexing of achievement unit light splitting pole.It will be appreciated to those of skill in the art that in photoelectric synchronous sense channel after setting completed, portion
Centre-to-centre spacing L for dividing the auroral poles of the auroral poles and adjacent photo sense channel of photoelectric synchronous sense channel is 2.5cm≤L≤4cm, also full
The requirement of sufficient near infrared light imaging.In order to substantially utilize imaging resources, appropriate adjustment light source electrode 12 to detect pole 13 with light
Arrangement angle so that centre-to-centre spacing L between the auroral poles of part adjacent photo synchronization sense channel is about 3cm, and adjacent auroral poles sets
It is light source electrode 12 to be set to different auroral poles, i.e., one, another light detection pole 13, realizes being multiplexed across the auroral poles of passage with this.
Those skilled in the art are also contemplated that when applying to imaging device, in the position of auroral poles multiplexing, can
Connected with the connection sheet 21 with length as 3cm and keep constant with the centre-to-centre spacing for ensureing adjacent auroral poles so that image quality is steady
It is fixed；And between the passage that can not meet auroral poles multiplexing, it is possible to use elastomeric material 22, such as elastic caoutchouc are attached, with reality
Existing imaging device entirety being adjusted flexibly with tested head circumference size.
The preferred embodiment of foregoing invention, by follow international " 10-20 " alignment system preferably go out 32 it is electric
The sides such as 11 position of pole, the distance that auroral poles is symmetrically arranged in 11 both sides of electrode, light interpolar is limited, the placed angle of adjustment auroral poles
Formula so that while auroral poles, 11 accurate positioning of electrode is ensured, realization carries out photoelectric synchronous detection in the range of full brain, and
Light interpolar maximizes multiplexing.
So far, technical scheme is described already in connection with preferred embodiment shown in the drawings, but, this area
Technical staff is it is easily understood that protection scope of the present invention is expressly not limited to these specific embodiments.Without departing from this
On the premise of the principle of invention, those skilled in the art can make the change or replacement of equivalent to correlation technique feature, these
Technical scheme after changing or replacing it is fallen within protection scope of the present invention.
Claims (9)
1. a kind of auroral poles-electrode arrangements method for full brain photoelectric synchronous cerebral function imaging,
Characterized in that, methods described comprises the steps：
The criterion for following international " 10-20 " alignment system chooses multiple photoelectric synchronous detecting electrode positions；
Electrode is positioned on selected photoelectric synchronous detecting electrode position；
Auroral poles is positioned over into the both sides of electrode.
2. auroral poles-electrode arrangements the method for full brain photoelectric synchronous cerebral function imaging according to claim 1, its feature
It is that methods described also includes the placed angle of adjustment auroral poles, with the multiplexing of achievement unit light splitting pole.
3. auroral poles-electrode arrangements the method for full brain photoelectric synchronous cerebral function imaging according to claim 1, its feature
It is that " 10-20 " alignment system refers to the recessed nose between people's scalp surface is with two, rear side occipital protuberance, both sides mastoid process
For reference point, along around, head circumference orientation measurement scalp surface, and the space bit of scalp surface is marked according to special ratios
The coordinate system put.
4. auroral poles-electrode arrangements the method for full brain photoelectric synchronous cerebral function imaging according to claim 1, its feature
It is that the auroral poles includes that the light source electrode for sending light source and the light for receiving light source detect pole, the smooth source electrode and institute
State light detection pole and be collectively forming light sense channel.
5. auroral poles-electrode arrangements the method for full brain photoelectric synchronous cerebral function imaging according to claim 4, its feature
It is with the light, the smooth source electrode detects that pole is symmetrically arranged at the both sides of the electrode.
6. auroral poles-electrode arrangements the method for full brain photoelectric synchronous cerebral function imaging according to claim 4, its feature
It is with the light, the smooth source electrode detects that centre-to-centre spacing L of pole is 2.5cm≤L≤4cm.
7. auroral poles-electrode arrangements for full brain photoelectric synchronous cerebral function imaging according to any one of claim 1 to 6
Method, it is characterised in that the criterion for following international " 10-20 " alignment system chooses multiple photoelectric synchronous detection electricity
The step of pole position, further includes：The criterion for following international " 10-20 " alignment system chooses 32 photoelectric synchronous inspections
Survey electrode position.
8. auroral poles-electrode arrangements the method for full brain photoelectric synchronous cerebral function imaging according to claim 7, its feature
It is that the auroral poles detection is carried out based near infrared spectrum imaging, and its wavelength is between 650～950nm.
9. auroral poles-electrode arrangements the method for full brain photoelectric synchronous cerebral function imaging according to claim 2, its feature
It is that the auroral poles multiplexing is referred to
Pole.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108523886A (en) * | 2018-05-10 | 2018-09-14 | 中国人民解放军陆军军医大学第附属医院 | A kind of intelligent electrode fixation band |
| CN111227790A (en) * | 2020-01-08 | 2020-06-05 | 北京师范大学 | Near-infrared probe arrangement method based on brain functional region positioning and head cap |
| CN114246556A (en) * | 2022-03-01 | 2022-03-29 | 慧创科仪(北京)科技有限公司 | Positioning method, apparatus and storage medium for near-infrared brain function imaging device |
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| CN102715889A (en) * | 2012-06-11 | 2012-10-10 | 天津大学 | Mental load detection method |
| CN102779229A (en) * | 2012-06-14 | 2012-11-14 | 天津大学 | Self-adapting automation method based on brain function state |
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| CN108523886A (en) * | 2018-05-10 | 2018-09-14 | 中国人民解放军陆军军医大学第附属医院 | A kind of intelligent electrode fixation band |
| CN108523886B (en) * | 2018-05-10 | 2023-12-01 | 中国人民解放军陆军军医大学第一附属医院 | Intelligent electrode fixing band |
| CN111227790A (en) * | 2020-01-08 | 2020-06-05 | 北京师范大学 | Near-infrared probe arrangement method based on brain functional region positioning and head cap |
| CN114246556A (en) * | 2022-03-01 | 2022-03-29 | 慧创科仪(北京)科技有限公司 | Positioning method, apparatus and storage medium for near-infrared brain function imaging device |
| CN114246556B (en) * | 2022-03-01 | 2022-05-24 | 慧创科仪(北京)科技有限公司 | Positioning method, apparatus and storage medium for near-infrared brain function imaging device |
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