CN106510616B - The full-automatic detector of xerophthalmia - Google Patents
The full-automatic detector of xerophthalmia Download PDFInfo
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- CN106510616B CN106510616B CN201611149801.XA CN201611149801A CN106510616B CN 106510616 B CN106510616 B CN 106510616B CN 201611149801 A CN201611149801 A CN 201611149801A CN 106510616 B CN106510616 B CN 106510616B
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- conically shaped
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- xerophthalmia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0008—Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/101—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the tear film
Abstract
The invention discloses a kind of full-automatic detectors of xerophthalmia, it include: probe assembly, it includes the image-forming assembly set gradually, lighting source, camera module, camera fixing device, control panel and cover board, the image-forming assembly includes optical filter, fixes sleeve and conically shaped, the conically shaped is set as chequered with black and white cyclic structure, black ring is formed by silk screening ink, the ink under infrared light transmissive, can not transmit under white light；Handle, first end are connected to the lower end of the probe assembly；Mancarried device comprising pedestal, adjusts hand lever and adjustable bed component at head rest component；And analytical equipment comprising image data acquiring unit, data detecting unit and data analysis unit.Black ring-type is infrared to part invisible on conically shaped in the present invention, to white light as it can be seen that meeting four kinds of imaging pattern demands, without removing Placido conically shaped when use, has simplified process for using, conically shaped is not easy to lose.
Description
Technical field
The present invention relates to a kind of xerophthalmia detection device, especially a kind of full-automatic detector of xerophthalmia.
Background technique
Xerophthalmia refers under tear quality and quantity exception caused by any reason or the extremely caused tear film stability of dynamics
Drop, and with ophthalmic uncomfortable, the general name for a variety of diseases for causing ocular lesion tissue to be characterized, also known as angle xerosis of conjunctiva.Often
See symptom to include that eyes are dry and astringent, are easy tired, eye itch, have sticky foreign body sensation, pain burning heat sensation, secretion, fear of wind, photophobia, externally
Boundary's stimulation is very sensitive.The adult of one investigation display 10%-15% in the U.S. suffers from dry eyes, and Japan is 17%, Australia
It is 10.3%, the dry eyes illness rate in China is about in 21%-33.7%, and the disease incidence of dry eyes worldwide is on year by year at present
The trend of liter, with the reasons such as being widely used of electronic curtain, the wearing of the abuse of environmental degradation, eye drops, contact lenses, dry eyes
Disease will also continue to increase, and clinician is badly in need of a kind of quick, portable, contactless, objective, quantitative, comprehensive xerophthalmia of intelligence
Analytical equipment auxiliary diagnosis.It is lacked according to two class of pathological characteristics dry eyes classification, including lipid shortage type dry eyes (LTD) and aqueous
Weary type dry eyes (ATD).Analysis comprehensively can be made to xerophthalmia class by the present invention as a result, auxiliary doctor is for different type and different journeys
The dry eyes of degree formulate individualized treatment scheme, improve therapeutic effect, reduce patient suffering.
Currently used xerophthalmia detection method mainly includes intrusive breakup time of tear film detection, Schimer's test
(such as Schirmer I and II test), slit lamp examination and the German OCULUS Keratograph 5M released recently etc..Tradition
Breakup time of tear film (BUT) detection be corneal fluorescein sodium dyeing after under slit-lamp microscope observe cornea occur first
The time of dry spot, inspection result accuracy dependent on observer experience and coloring agent to the stability of tear film；Lacrimal secretion
Test carries out tear measurement using standard testing strips, and the China and foreign countries 1/3 that two standard testing strips are gently put into conjunctival sac under tested eye are handed over
At boundary, patient looks down or gently closes one's eyes, and removes test paper after five minutes, test paper scale is read after placing one minute, according to test value
Judge diagnostic result, this method can also be dripped in patient tests basic value under surface anesthesia state, and test paper stimulation itself is avoided to lead
The lacrimal secretion of cause influences the accuracy of test result, Schimer's test method be also the common method of current Clinical Ophthalmology it
One, it is at low cost, but the test process duration is long, and intrusive method brings certain sense of discomfort to patient；Keratograph
5M can more fully analyze dry eye condition, but the equipment is larger, and portability is poor, higher cost, and popularization is bad.
Meanwhile the blackstreak part of the Placido ring in existing dry eyes analyzer image-forming assembly is inked using conventional oil
Brush needs to remove Placido conically shaped after breakup time of tear film measurement, then carries out lacrimal river elevation carrection, lipid layer
Image Acquisition and Meibomian gland Image Acquisition need again to install Placido conically shaped after three kinds of measurements, this design
Mode undoubtedly gives operation doctor to bring certain trouble, and Placido conically shaped remove after be easily lost.
Summary of the invention
In view of the above technical problems, the invention discloses a kind of full-automatic detector of xerophthalmia, the image-forming assembly is by filtering
Piece, fixes sleeve and conically shaped composition, Placido conically shaped ring design are chequered with black and white cyclic structure, totally 10 ring, tear film
Chequered with black and white ring-type is imaged in photographing module in Placido ring when rupture time inspection requirements is imaged, then in other three kinds of inspections
It is imaged without ring-type, therefore it is required that black annulus white light imaging is as it can be seen that infrared imaging is invisible, according to this imaging demand, black
Annulus selects specialty inks silk-screen printing, guarantees black annulus imagewise uniform, and black ring-type is infrared to part not
As it can be seen that without removing Placido conically shaped when use, having simplified using stream to white light as it can be seen that meet four kinds of imaging pattern demands
Journey.This kind of specialty inks have passed through experimental verification, meet imaging requirements.
In order to realize these purposes and other advantages according to the present invention, a kind of full-automatic detector of xerophthalmia is provided,
Include:
Probe assembly comprising image-forming assembly, lighting source, camera module, the camera fixing device, control set gradually
Plate and cover board are provided with exit portal on the image-forming assembly, and the lighting source and camera assembly are respectively aligned to the outgoing
Mouthful；The image-forming assembly includes optical filter, fixes sleeve and conically shaped, and the fixes sleeve is arranged to optically focused cavity configuration, institute
The big opening for stating laser pump cavity is directed at the exit facet of the lighting source, and the optical filter is arranged in the lighting source and laser pump cavity
Between optical path on, the conically shaped is placido conically shaped, the small opening of the tapered end of the conically shaped from the laser pump cavity
It protrudes into the laser pump cavity, the planar bottom end of the conically shaped is resisted against in the small opening of the laser pump cavity, the conically shaped setting
For chequered with black and white cyclic structure, totally 10 ring, black ring are formed by silk screening ink for black ring and white ring, and the ink is under infrared light
Transmissive can not transmit under white light；
Handle, first end are connected to the lower end of the probe assembly, and the handle is set as bendable structure；
Mancarried device, the handle are removably arranged on the mancarried device；And
Analytical equipment is integrated in PC machine, and the analytical equipment and the probe assembly communicate to connect, the analysis dress
It sets including image data acquiring unit, data detecting unit and data analysis unit.
Preferably, the lighting source is LED annular light source, including circuit substrate and is evenly arranged on circuit substrate
Near-infrared LED, white light LEDs, circuit substrate use ring structure, aluminum substrate material, and the near-infrared LED wavelength is 850nm, closely
Infrared LED and white light LEDs interval are arranged to annular light source structure, and several circles have been arranged concentrically on the circuit substrate and have been evenly arranged
Near-infrared LED and white light LEDs, near-infrared LED and white light LEDs are all independent drivings and brightness is adjustable, the circuit substrate, filter
Mating plate and the alignment of conically shaped center offer through-hole to form the exit portal being emitted outward, and the exit portal alignment is suffered from
Person's eye.
Preferably, diffusing reflection coating is coated on the inner sidewall of the laser pump cavity, the emergent ray of the lighting source passes through
The diffusing reflection coating uniform is reflected on the conical surface of the conically shaped.
Preferably, the camera module is high-resolution color mould group, supports the imaging of white light wave band, 850nm near-infrared wave
Section imaging, supports auto-focusing, and focusing position is controllable, and there are many corresponding from different measurement patterns for the camera module configuration
Imaging pattern, and the imaging pattern of camera module can be switched over by PC machine.
Preferably, the mancarried device includes pedestal, head rest component, adjusts hand lever and adjustable bed component, described
Head rest component bottom is fixed on the base, and the adjustable bed component is movably arranged on described by the adjusting hand lever
On pedestal, the handle second end is detachably arranged on the adjustable bed component.
Preferably, the camera fixing device is cylindrical-shaped structure, and the camera fixing device front and rear sides respectively offer
Interconnected cavity, the optical filter, lighting source and camera module are successively set on the front side cavity from outside to inside
Interior, the laser pump cavity big opening of the fixes sleeve is fixed on the outside of the cavity of front side, and the control panel is arranged in rear side cavity, and
With the cover closure, the control panel input terminal is communicated to connect by serial interface and PC machine, the output end of the control panel
It is connect by light source control module with the lighting source, patient's eye is imaged in the camera module, and will be described in generation
Image is transmitted to the PC machine by USB interface.
Preferably, the handle is hollow structure, and the probe assembly connecting line passes through the handle and the analysis fills
Connection is set, the handle can be separated into independent hand-held analytical equipment from the mancarried device；The head rest component is set
It sets at probe assembly rear, all around adjusts adjustable bed component and probe assembly phase by swing adjustable hand lever
For the distance all around of head rest component, by being rotated up and down adjustable hand lever come the Lower jaw support of adjustable head prop component relative to spy
The upper and lower position of head assembly.
Preferably, the data detecting unit includes that breakup time of tear film checks module, lacrimal river elevation carrection module, tarsus
Gland Image Acquisition and enhancing module, lipid layer analysis module, the data detecting unit pass through described image data acquisition unit
It is connect with the camera module, described image data acquisition unit exports eyes image, the data by video terminal in real time
Detection unit output end is connect with the data analysis unit, and the data analysis unit will be examined by information management output unit
Survey report output.
Preferably, be provided on the handle the first breakup time of tear film review button, the first lacrimal river elevation carrection button,
First Meibomian gland Image Acquisition and enhancing button, the first lipid layer analysis button, each button and corresponding measurement pattern are corresponding,
Every kind of measurement pattern corresponds to a kind of light illumination mode and imaging pattern.
Preferably, the PC machine signal input part is provided with the second breakup time of tear film review button, the second lacrimal river height
Button, the second Meibomian gland Image Acquisition and enhancing button, the second lipid layer analysis button are measured, each button is measured with corresponding
Mode is corresponding, and every kind of measurement pattern corresponds to a kind of light illumination mode and imaging pattern.
The present invention is include at least the following beneficial effects:
1, the device measurement result is accurate, objective, stable, and the review time is short, can quickly be shown in video terminal；
2, checking process of the present invention is non-intrusion type, reduces patient suffering, reduces and checks difficulty；
3, the portable dry eyes analytical equipment portability of the present invention is strong, and illumination and image-forming assembly are ingenious in design, and bottom structure is simultaneous
Hold crack modulated structure, can be removed when using as handheld device is especial patient inspection, it can also be placed on the lamp base of crack and use,
It is a kind of three kinds of application methods of design, not only doctor is facilitated to operate, also saved the sky of ophthalmology consulting room preciousness to a certain extent
Between resource；
4, imaging system lighting source of the present invention is designed as multi-mode LED annular light source, provides uniform, stable, reliable
Infrared and white-light illuminating environment, light source and brightness are adjustable, realize the automatic switchover of dry eyes checking mode；
5, the design of device image-forming assembly is small and exquisite, and Placido tapered cartridge design substitutes existing Placido ring design, guarantees
Breakup time of tear film statistical accuracy while, realize the simplification of Placido ring structure；
6, xerophthalmia Comprehensive Analysis Software system completes the diagnostic analysis to four aspects of xerophthalmia, including when tear film rupture
Between check, lacrimal river elevation carrection.Meibomian gland image taking and enhancing, lipid layer analysis；
7, conical ring is arranged to chequered with black and white cyclic structure, the specialty inks silk-screen printing of black annulus is protected
Black annulus imagewise uniform is demonstrate,proved, and black ring-type is infrared to part invisible, to white light as it can be seen that meeting four kinds of imaging patterns
Demand has simplified process for using, conically shaped is not easy to lose without removing Placido conically shaped when use.
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Detailed description of the invention
Fig. 1 is the schematic illustration of detector of the present invention；
Fig. 2 is the structural schematic diagram of probe assembly；
Fig. 3 is the structural schematic diagram of lighting source；
Fig. 4 is the structural schematic diagram of mancarried device；
Fig. 5 is the front view of conically shaped.
Specific embodiment
Present invention will be described in further detail below with reference to the accompanying drawings, to enable those skilled in the art referring to specification text
Word can be implemented accordingly.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein do not allot one or more
The presence or addition of a other elements or combinations thereof.
The invention discloses a kind of new full-automatic detectors of xerophthalmia, including sample of high-resolution image module, intelligence
Light source control module, the probe assembly of Multifunction ring light source module composition, xerophthalmia Comprehensive Analysis Software analysis module, handle
And mancarried device, realize breakup time of tear film check-up through statistical means, lacrimal river elevation carrection, the enhancing of Meibomian gland Image Acquisition and human eye rouge
The functions such as matter layer analysis provide foundation for clinical xerophthalmia diagnosis, are suitable for Clinical Ophthalmology and diagnose the medical treatment of its related fields answering
With, while probe assembly being minimized, by entire xerophthalmia analytical equipment portability, it is only that probe assembly can be used as handheld device
Vertical to use, occupied space is smaller, using more convenient, applicability is stronger.
Currently, the blackstreak part of Placido conical ring is printed using common ink, measures and tie in breakup time of tear film
It needs to remove Placido conically shaped after beam, then carries out lacrimal river elevation carrection, lipid layer Image Acquisition and Meibomian gland image and adopt
Collection needs again to install Placido conically shaped after three kinds of measurements, this design pattern undoubtedly gives operation doctor to bring
Certain trouble, and Placido conically shaped remove after be easily lost.The present invention is in view of the above-mentioned problems, propose a kind of new do
The eye full-automatic detector of disease, the conically shaped are set as chequered with black and white cyclic structure, and black ring and white ring totally 10 ring, black ring is by oil
Black silk-screen printing forms, the ink under infrared light transmissive, can not transmit under white light, without being measured in breakup time of tear film
After need to remove Placido conically shaped, whole process can complete tear film rupture under the premise of Placido conically shaped is not removed
Time measurement, lacrimal river elevation carrection, the enhancing of Meibomian gland Image Acquisition and human eye lipid layer analysis this 4 analytic functions, simplify
Operating process improves detection efficiency, and conically shaped is not easy to lose.
Embodiment one
A kind of way of realization according to the present invention as shown in Fig. 1, including: the spy for being shot to patient's eye
Head assembly, the mancarried device with the handle of probe assembly integral structure, for carrying probe assembly, to image carry out it is multiple
The analysis system of symptom analysis and by image, data, the terminal of report output.
Probe assembly 4 is integrated for one and is fixed by image-forming assembly, lighting source 44, camera module 45, camera in the present invention
The integral structure of device 46, control panel 47 and cover board 48, as shown in Fig. 2, image-forming assembly, lighting source 44 and camera module
45 are fixed on the side of camera fixing device 46, and the control panel 47 is fixed on the other side of the camera fixing device 46, together
When, it is closed with cover board 48 into a complete structure, image-forming assembly includes the conically shaped 41 set gradually, fixes sleeve 42 and filter
Mating plate 43, the fixes sleeve 42 are arranged to optically focused cavity configuration, and opening is respectively offered before and after laser pump cavity, and the laser pump cavity is opened greatly
Mouth is directed at the exit facet of the lighting source 44, and the light between the lighting source 44 and laser pump cavity is arranged in the optical filter 43
On the road, the conically shaped 41 is placido (Placido) conically shaped, and the tapered end of the conically shaped 41 is from the small of the laser pump cavity
Opening protrudes into the laser pump cavity, so that entire conically shaped 41 is accommodated in one heart in the laser pump cavity, the conically shaped 41 is put down
Bottom end is resisted against in the small opening of the laser pump cavity, and the design of device image-forming assembly is small and exquisite, and Placido tapered cartridge design substitution is existing
Placido ring design, while the breakup time of tear film statistical accuracy of guarantee, realize simplifying for Placido ring structure
Change, entire probe assembly is minimized, the size of last probe assembly 4 is reduced to diameter and length is 10cm or so, occupies
Space is small, and applicability is stronger.
Meanwhile as shown in figure 5, the conically shaped is set as chequered with black and white cyclic structure, black ring and white ring totally 10 ring are black
Ring is formed by silk screening ink, the ink under infrared light transmissive, can not transmit under white light；Specifically, the present invention couple
The design of conically shaped is improved, and Placido conically shaped ring design is chequered with black and white ring-type, totally 10 ring, compared with the existing technology,
Reduce number of rings, reduces the size of probe assembly, Placido ring is in photographing module when breakup time of tear film inspection requirements is imaged
Chequered with black and white ring-type is imaged, is then not necessarily to cyclic annular imaging in other three kinds of inspections, therefore it is required that black annulus white light imaging as it can be seen that
Infrared imaging is invisible, and according to this imaging demand, we select specialty inks silk-screen printing to black annulus, guarantees black ring
Shape part imagewise uniform, and black ring-type is infrared to part invisible, to white light as it can be seen that meeting four kinds of imaging pattern demands,
In detection process, without removing Placido conically shaped, process for using is simplified, has improved detection efficiency, and conically shaped is not easy to lose
It loses.And this kind of specialty inks have passed through experimental verification, meet imaging requirements.
In the present embodiment, the camera fixing device 46 is cylindrical-shaped structure, 46 front and rear sides of camera fixing device
Interconnected cavity is respectively offered, the optical filter 43, lighting source 44 and camera module 45 are set gradually from outside to inside
In the front side cavity, the laser pump cavity big opening of the fixes sleeve 42 is fixed on the outside of the cavity of front side, and front side cavity is sealed
It closes, the control panel 47 is arranged in rear side cavity, and is closed with the cover board 48, and 47 input terminal of control panel passes through serial ports
Interface and PC machine communicate to connect, and the output end of the control panel is connect by light source control module with the lighting source 44, institute
It states perforation before and after being provided on image-forming assembly and offers exit portal, the lighting source and camera assembly are respectively aligned to the outgoing
Mouthful, exit portal is directed at eyes of patients, patient's eye is imaged in the camera module, and the described image of generation is passed through USB
Interface is transmitted to the PC machine.
It is LED annular light source that the lighting source 44, which uses, as shown in figure 3, including circuit substrate 440 and being evenly arranged
Near-infrared LED 441, white light LEDs 442 on circuit substrate 440, circuit substrate 440 use ring structure, aluminum substrate material,
The near-infrared LED wavelength is 850nm, and near-infrared LED and white light LEDs interval are arranged to annular light source structure, the circuit base
Be arranged concentrically the near-infrared LED and white light LEDs that two circles are evenly arranged on plate, make its uniform irradiation in eyes of patients, improve at
Image quality amount, wherein near-infrared LED can independently drive and brightness is adjustable, and white light LEDs can also independently drive and brightness is adjustable, at
Picture system illumination light source design is multi-mode LED annular light source, provides uniform, stable, reliable infrared and white-light illuminating ring
Border, light source and brightness are adjustable, realize the automatic switchover of dry eyes checking mode.
47 input terminal of control panel is communicated to connect by serial interface and PC machine, and the output end of the control panel 47 passes through
Light source control module is connect with the lighting source 44, and light source control module controls the light illumination mode of lighting source 44, specifically,
When carrying out breakup time of tear film check-up through statistical means, light illumination mode is adjusted to white light, adjusts the intensity of irradiation light；It is high to carry out lacrimal river
When degree measurement, it is also adjusted to white light, and adjust intensity of illumination；When carrying out the enhancing of Meibomian gland Image Acquisition, also it is adjusted to
White light, and adjust intensity of illumination；When carrying out human eye lipid layer analysis, it is adjusted near infrared light, adjusts intensity of illumination.
After the mode that measures is selected, above-mentioned white light or near infrared light switch over automatically, and the corresponding intensity of illumination of adjust automatically,
To adapt to different testing requirements.
It is high-resolution color mould group that the camera module 45, which uses, is taken pictures into for carrying out high definition to eyes of patients
Picture supports the imaging of white light wave band, the imaging of 850nm near infrared band, and supports auto-focusing, and focusing position is controllable, described to take the photograph
There are many imaging pattern corresponding from different measurement patterns, camera modules 45 to pass through USB interface and PC machine control for the configuration of picture mould group 45
End connection processed, is transmitted to the PC machine for the eye high-definition image of shooting, and imaging pattern can be cut by PC machine control terminal
It changes, the PC machine signal input part is provided with the second review button of breakup time of tear film, the second lacrimal river elevation carrection button, second
Meibomian gland Image Acquisition and enhancing button, the second lipid layer analysis button, when selecting one of button, lighting source 44
Light illumination mode automatically switches to corresponding illumination mode, meanwhile, mode is imaged in 45 adjust automatically of camera module, and progress is automatic right
Coke carries out high definition imaging to eyes of patients.
Mancarried device, the mancarried device include head rest component 1, adjustable hand lever 2, adjustable bed component 3, probe group
4 lower end of part is provided with one handle, that is to say, that handle first end is connected to the lower end of the probe assembly 4, the handle setting
For bendable structure, the relative position of adjustment probe assembly 4 and handle can be facilitated, handle second end passes through a dismountable part
It is arranged on the adjustable bed component 3, head rest component 1 is arranged at 4 rear of probe assembly, when patient is located in head rest component
After on 1, adjustable bed component 3 and probe assembly 4 all around are adjusted relative to head rest by swing adjustable hand lever 2
The distance all around of component 1, while by being rotated up and down adjustable hand lever 2 come the upper bottom of the Lower jaw support of adjustable head prop component 1
It sets, so as to adjust position of human eye, so that the lighting source and camera module in probe assembly 4 are aligned with eyes of patients, reaches most
Good imaging effect realizes quick image checking, detection efficiency is improved, while probe assembly being minimized, by entire xerophthalmia
Analytical equipment portability, probe assembly can be used as handheld device, and to be independently operated, occupied space smaller, using more convenient, applicable
Property is stronger.
And
Analytical equipment is integrated in PC machine, and the analytical equipment and the probe assembly communicate to connect, the analysis dress
It sets including image data acquiring unit, data detecting unit and data analysis unit and information management output unit unit, institute
Stating data detecting unit includes that breakup time of tear film checks module, lacrimal river elevation carrection module, Meibomian gland Image Acquisition and enhancing
Module, lipid layer analysis module, the data detecting unit are connected by described image data acquisition unit and the camera module
Connect, described image data acquisition unit exports eyes image by video terminal in real time, the data detecting unit output end with
The data analysis unit connection, the data analysis unit will test report output by information management output unit.
The PC machine signal input part is connect by the communication module with the serial interface and USB interface, is led to
Letter and data transmission are used for handover measurement modes in parallel into corresponding control light illumination mode and imaging pattern.Described image data
Acquisition unit input terminal is connect with the output end of the camera module 45, and eyes image is transmitted to PC machine end, described image number
According to acquisition unit output end respectively with breakup time of tear film check module, lacrimal river elevation carrection module, Meibomian gland Image Acquisition and
Enhance module, lipid layer analysis module and video terminal connection, the eyes image shot under each pattern is transmitted to accordingly
Detection module, meanwhile, the data analysis unit respectively with breakup time of tear film check module, lacrimal river elevation carrection module,
Meibomian gland Image Acquisition and enhancing module, lipid layer analysis module output end connection, by each module acquisition generate data into
The corresponding analysis of row, obtains testing result.Meanwhile video terminal directly displays the image of shooting, for intuitively showing and seeing
Analysis is examined, this analysis system measurement result is accurate, objective, stable, and the review time is short, can quickly be shown in video terminal.
The output end of the data analysis unit is connect with information management output unit, and the system is to four sides of xerophthalmia
The diagnostic analysis in face, including breakup time of tear film inspection, lacrimal river elevation carrection, Meibomian gland image taking and enhancing, lipid layer point
Analysis, the data that these detections are generated production report, printout after the processing of information management output unit.Meanwhile in PC machine
In to image data and detection data carry out storage stay shelves.
Specifically, the PC machine signal input part is provided with the second breakup time of tear film review button, the second lacrimal river height
Button, the second Meibomian gland Image Acquisition and enhancing button, the second lipid layer analysis button are measured, each button is measured with corresponding
Mode is corresponding, and every kind of measurement pattern corresponds to a kind of light illumination mode and imaging pattern, under every kind of measurement pattern, adjust automatically illumination light
The light illumination mode in source 44 and the imaging pattern of camera module 45, when selecting one of button, the illumination mould of lighting source 44
Formula automatically switches to corresponding illumination mode, meanwhile, mode is imaged in 45 adjust automatically of camera module, and carries out auto-focusing, right
Eyes of patients carry out high definition imaging.The lighting source 44 irradiates at patient's eye through the image-forming assembly, provides illumination, with
The camera module 45 carries out high definition imaging to patient's eye afterwards, and the described image of generation is transmitted to institute by USB interface
It states PC machine and carries out data analysis and detection, and stored and shown analysis, checking process is non-intrusion type, reduces patient's pain
Hardship reduces and checks difficulty.
Embodiment two
In the present embodiment, the handle is hollow structure, and 4 connecting line of probe assembly passes through the handle and described point
Analysis apparatus connection, the handle can be separated into independent hand-held analytical equipment from the mancarried device；The head rest group
Part setting all around adjusts adjustable bed component and probe group at probe assembly rear, by swing adjustable hand lever
All around distance of the part relative to head rest component, it is opposite come the Lower jaw support of adjustable head prop component by being rotated up and down adjustable hand lever
In the upper and lower position of probe assembly.Specifically, handle, at its lower end is arranged by a dismountable part in the adjustable bed group
On part 3, head rest component 1 is arranged at 4 rear of probe assembly, after patient is located on head rest component 1, by swinging adjustable hand lever
2 all around adjust the distance all around of adjustable bed component 3 and probe assembly 4 relative to head rest component 1, together
When made by being rotated up and down the upper and lower position of Lower jaw support of the adjustable hand lever 2 come adjustable head prop component 1 so as to adjust position of human eye
Lighting source in probe assembly 4 and camera module are aligned with eyes of patients, reach optimal imaging effect, realization quickly at
As detection, detection efficiency is improved, and portability is strong, adaptability is higher.
Some especial patients are directed to, can not be placed into the detection device from head is about to, in order to be done for these patients
Eye detects, and it is specific disease that the handle in the present embodiment, which can be disassembled from adjustable bed component 3 as handheld device,
People checks that only handheld device need to be directed at eyes of patients can check that patient can be can be completed with recumbency entirely to be detected
Journey, it is convenient to provide for patient and operator, which can also be placed on the lamp base of crack and use, can deep space resources, can
A kind of three kinds of application methods of design are called, not only doctor is facilitated to operate some inconvenience, has also saved ophthalmology to a certain extent and examined
The space resources of room preciousness.
Embodiment three
On the basis of example 1, when removing probe assembly as independent handheld device, in order to easy to operate,
The first breakup time of tear film review button, the first lacrimal river elevation carrection button, the first Meibomian gland figure are provided on the handle
As acquiring and enhancing button, the first lipid layer analysis button, each button and corresponding measurement pattern are corresponding, every kind of measurement pattern
A kind of corresponding light illumination mode and imaging pattern, when selecting one of button, the light illumination mode of lighting source 44 automatically switches
To corresponding illumination mode, meanwhile, mode is imaged in 45 adjust automatically of camera module, and carries out auto-focusing, to eyes of patients into
The imaging of row high definition.Specifically, be respectively arranged with the button of control measurement pattern in PC machine and on handle, each button and corresponding
Measurement pattern it is corresponding, every kind of measurement pattern corresponds to a kind of light illumination mode and imaging pattern, under every kind of measurement pattern, adjust automatically
The light illumination mode of lighting source 44 and the imaging pattern of camera module 45, when selecting one of button, lighting source 44
Light illumination mode automatically switches to corresponding illumination mode, meanwhile, mode is imaged in 45 adjust automatically of camera module, and progress is automatic right
Coke carries out high definition imaging to eyes of patients.The lighting source 44 irradiates at patient's eye through the image-forming assembly, provides photograph
Bright, the subsequent camera module 45 carries out high definition imaging to patient's eye, and the described image of generation is transmitted by USB interface
Data analysis and detection are carried out to the PC machine, and is stored and shown analysis, checking process is non-intrusion type, reduces patient
Pain reduces and checks difficulty.When removing handle, when probe assembly becomes independent hand-held detection device, operator can be
The switching that measurement pattern is carried out on handle improves measurement efficiency and convenience to realize off line, independent operation.
Example IV
On the basis of embodiment one or embodiment two, diffusing reflection coating, institute are coated on the inner sidewall of the laser pump cavity
The emergent ray for stating lighting source is reflected on the conical surface of the conically shaped through the diffusing reflection coating uniform, and emergent light is met
Onto the conical surface of conically shaped, the validity of irradiation light is enhanced, polarisation, light leakage are reduced, so that emergent light cover is in patient
Eye provides better illuminating effect, and then improves imaging effect, improves accurate, the objective and stability of measurement result.
Embodiment five
On the basis of example 1, the circuit substrate 440, optical filter 45 and the alignment of 41 center of conically shaped offer
Through-hole, the taking lens of the camera module 45 provide shooting optical path by the through-hole alignment patient's eye for camera module 45,
The size for optimizing imaging optical path, reducing this probe assembly 4, by analysis system miniaturization, portability.
From the above mentioned, xerophthalmia comprehensive analysis device in the present invention, including sample of high-resolution image module, intelligent light source
Control module, Multifunction ring light source module, software module, data processing and control system meter and portable dry eyes comprehensive analysis dress
It sets.Sample of high-resolution image module can acquire color image and near-infrared image, and the automatic focusing function of acquisition module meets
Breakup time of tear film measures the imaging demand different from Meibomian gland image-forming principle；Multifunction ring light source module provides illumination ring
Border is connect by serial communication with PC machine, and host computer realizes uniform infrared photograph by software realization intelligent light source control module
Bright environment and white-light illuminating environment realize breakup time of tear film check-up through statistical means, lacrimal river elevation carrection, the enhancing of Meibomian gland Image Acquisition
And the functions such as human eye lipid layer analysis.
Simultaneously xerophthalmia overall analysis system of the invention include colored sense infrared photography mould group, LED ring illumination light source,
Control panel, portable dry eyes comprehensive analysis device and xerophthalmia overall analysis system module.Wherein camera module, ring illumination light
Source and control panel are integrated in inside mancarried device, and control panel realizes intelligent light source control function, control annular light source illumination system
System, provides multi-mode lighting environment, obtains image data by camera module, be transmitted to PC by USB interface, comprehensive through PC xerophthalmia
It closes the calculating of analysis system module analysis and the results are shown in PC video terminal, and diagnosis report can be exported by end print.
Mancarried device includes head rest component, adjustable bed component, adjustable hand lever, probe assembly, display screen, notebook
Computer etc..The front and rear, left and right position of adjustable bed and the upper and lower position of Lower jaw support are adjusted by adjustable hand lever, thus real
Now quick accurately pupil alignment function；Instrument host is connected by the USB3.0 interface of bottom with laptop, is realized
Mutual communication and correlation function are realized.Probe assembly is mainly by Placido conically shaped, fixes sleeve, annular light source, CCD phase
The composition such as machine, camera fixing device, structure design is easy to disassemble and installs.
Imaging system includes camera module, LED annular light source, probe assembly, control panel and USB device interface, wherein taking the photograph
As mould group, LED annular light source and control panel are integrated in inside imaging system device, camera module is connect with PC machine, and control panel connects
Annular light source is connect, light source control is realized by PC Communication, is responsible for the control of signal and the input and output of data by PC.
Xerophthalmia Comprehensive Analysis Software system module is arranged in the end PC, is shown, is stored and related to the image of camera module acquisition
Resume module, and measurement result is shown, stored and is printed out.The brightness of annular light source inside appliance imaging system
It adjusts and light source switch control is sent a signal to by PC sections and gives input, software systems are schemed for carrying out processing image data acquiring
As data analytical judgment and the output of diagnostic result.
Circuit of light sources uses ring structure, aluminum substrate material, and near-infrared LED wavelength is that 850nm meets imaging requirements.Annular
Light source design two is enclosed, and infrared LED and the alternate aluminum substrate two that is evenly arranged in of white light LEDs enclose, and guarantees that brightness of illumination is uniform.It is infrared
Light source design is that brightness is adjustable, and it is adjustable that white light source is designed as brightness.
Mancarried device includes head rest component 1, adjustable hand lever 2, adjustable bed component 3, probe assembly 4.By adjustable
The front and rear, left and right position of the adjustable adjustable bed of hand lever and the upper and lower position of Lower jaw support, so as to adjust position of human eye,
Reach optimal imaging effect.
Probe assembly 4 by Placido conically shaped 41, fixes sleeve 42, optical filter 43, annular light source 44, camera module 45,
Camera fixing device 46, control circuit board 47 and cover board 48 form.Probe assembly lower support structure is compatible with slit-lamp, uses
When can be placed on crack lamp base, hand-held use can also be taken off.
Camera module selects high-resolution color mould group, supports the imaging of 850nm near infrared band, supports auto-focusing, right
Burnt position is controllable.Imaging pattern passes through the end PC software control.
Xerophthalmia Comprehensive Analysis Software system is arranged in PC machine, is connect by Serial Port Line and USB with constructional device, realizes logical
Letter and data interaction.Dry eyes Comprehensive Analysis Software system includes communication module, image data acquiring unit, breakup time of tear film inspection
Look into module, lacrimal river elevation carrection module, Meibomian gland Image Acquisition and enhancing module, data analysis module and information management output mould
Block, it is final to realize xerophthalmia comprehensive analysis function.
Placido conically shaped is designed for breakup time of tear film inspection, and head is placed under head rest 1 by those who are investigated when inspection
At jaw, operation doctor is adjusted by adjustable hand lever 2 so that human eye (left eye or right eye) is directed at imaging center, and measured's eyes are just
It depending on front, normally twinkles after the site alignment pupil of center, then measured is enjoined to open eyes always until system automatically records out
Tear film rupture time and site for the first time.Measurement needs rest at least 1 minute of closing one's eyes again, and data analysis module supports repeatedly measurement
Repeatedly record facilitates doctor to statistically analyze the state of an illness；After breakup time of tear film checks, lacrimal river elevation carrection can be carried out, first
Without removing Placido conically shaped, head is placed at 1 lower jaw of head rest operation doctor by measured, tear of the operation doctor to patient
River image is grabbed, and is measured with the measuring tool of software systems to the lacrimal river height immediately below pupil center；Tarsus
Gland Image Acquisition includes upper eyelid and palpebra inferior Meibomian gland infrared imaging, enhances analysis processing by software systems, assists doctor
Clinical dry eye diagnostic；Lipid layer analysis imaging, after enjoining measured to twinkle, grabs human eye lipid tomographic image.Four kinds of modes at
It is realized and is automatically switched by the software systems at the end PC as system, completed the illness analysis of xerophthalmia, then taken for the cause of disease
Individualized treatment scheme, for clinician provide it is a kind of directly, quickly, write, noninvasive, objective, comprehensive diagnosis basis is with auxiliary
Xerophthalmia is helped to diagnose.
The system and device measurement result are accurate, objective, stable, and the review time is short, can quickly be shown in video terminal；And
Entire checking process is non-intrusion type, reduces patient suffering, reduces and checks difficulty；It is strong to take formula dry eyes analytical equipment portability, shines
Bright and image-forming assembly is ingenious in design, and the compatible crack modulated structure of bottom structure, can be removed when using as handheld device is specific disease
People checks, can also be placed on the lamp base of crack and use, be a kind of three kinds of application methods of design, not only doctor is facilitated to operate,
The space resources of ophthalmology consulting room preciousness has been saved to a certain extent；Imaging system lighting source of the present invention is designed as multi-mode LED
Annular light source provides uniform, stable, reliable infrared and white-light illuminating environment, and light source and brightness are adjustable, realize dry eyes inspection
Look into the automatic switchover of mode；, the design of device image-forming assembly it is small and exquisite, Placido tapered cartridge design substitutes existing Placido ring and sets
Meter while the breakup time of tear film statistical accuracy of guarantee, realizes the simplification of Placido ring structure；Conical ring is set
It is set to chequered with black and white cyclic structure, the specialty inks silk-screen printing of black annulus guarantees that the imaging of black annulus is equal
It is even, and black ring-type is infrared to part invisible, to white light as it can be seen that meeting four kinds of imaging pattern demands, without removing when use
Placido conically shaped, has simplified process for using, and conically shaped is not easy to lose.Xerophthalmia Comprehensive Analysis Software system is completed to dry eyes
The diagnostic analysis of four aspects of disease, including breakup time of tear film inspection, lacrimal river elevation carrection, Meibomian gland image taking and enhancing,
Lipid layer analysis.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details and legend shown and described herein.
Claims (8)
1. a kind of full-automatic detector of xerophthalmia characterized by comprising
Probe assembly comprising the image-forming assembly that sets gradually, lighting source, camera module, camera fixing device, control panel with
And cover board, exit portal is provided on the image-forming assembly, and the lighting source and camera module are respectively aligned to the exit portal；Institute
Stating image-forming assembly includes optical filter, fixes sleeve and conically shaped, and the fixes sleeve is arranged to optically focused cavity configuration, the optically focused
The big opening of cavity configuration is directed at the exit facet of the lighting source, and the optical filter is arranged in the lighting source and laser pump cavity knot
In optical path between structure, the conically shaped is placido conically shaped, and the tapered end of the conically shaped is from the optically focused cavity configuration
Small opening protrudes into the optically focused cavity configuration, and the planar bottom end of the conically shaped is resisted against in the small opening of the optically focused cavity configuration,
The conically shaped is set as chequered with black and white cyclic structure, and totally 10 ring, black ring are formed by silk screening ink for black ring and white ring, should
Ink under infrared light transmissive, can not transmit under white light；
Handle, first end are connected to the lower end of the probe assembly, and the handle is set as bendable structure；
Mancarried device, the handle are removably arranged on the mancarried device；And
Analytical equipment is integrated in PC machine, and the analytical equipment and the probe assembly communicate to connect, the analytical equipment packet
Include image data acquiring unit, data detecting unit and data analysis unit；
Diffusing reflection coating is coated on the inner sidewall of the optically focused cavity configuration, the emergent ray of the lighting source is through described unrestrained anti-
Coating uniform is penetrated to be reflected on the conical surface of the conically shaped；
The lighting source be LED annular light source, including circuit substrate and be evenly arranged on circuit substrate near-infrared LED,
White light LEDs, circuit substrate use ring structure, aluminum substrate material, the near-infrared LED wavelength be 850nm, near-infrared LED and
White light LEDs interval is arranged to annular light source structure, and several near-infrareds for enclosing and being evenly arranged are arranged concentrically on the circuit substrate
LED and white light LEDs, near-infrared LED and white light LEDs are all independent drivings and brightness is adjustable, the circuit substrate, optical filter and
The alignment of conically shaped center offers through-hole to form the exit portal being emitted outward, and the exit portal is directed at eyes of patients.
2. the full-automatic detector of xerophthalmia as described in claim 1, which is characterized in that the camera module is that high-resolution is color
Color mould group supports the imaging of white light wave band, the imaging of 850nm near infrared band, supports auto-focusing, and focusing position is controllable, described
There are many imaging patterns corresponding from different measurement patterns for camera module configuration, and the imaging pattern of camera module can pass through PC machine
It switches over.
3. the full-automatic detector of xerophthalmia as claimed in claim 2, which is characterized in that the mancarried device include pedestal,
Head rest component adjusts hand lever and adjustable bed component, and the head rest component bottom is fixed on the base, the adjustable work
Make platform component to be movably arranged on the pedestal by the adjusting hand lever, the handle second end is detachably arranged in described
On adjustable bed component.
4. the full-automatic detector of xerophthalmia as claimed in claim 3, which is characterized in that the camera fixing device is cylindric
Structure, the camera fixing device front and rear sides respectively offer interconnected cavity, the optical filter, lighting source and take the photograph
As mould group is successively set on from outside to inside in the cavity of front side, it is empty that the optically focused cavity configuration big opening of the fixes sleeve is fixed on front side
On the outside of chamber, the control panel is arranged in rear side cavity, and with the cover closure, and the input terminal of the control panel passes through serial ports
Interface and PC machine communicate to connect, and the output end of the control panel is connect by light source control module with the lighting source, described
Patient's eye is imaged in camera module, and the image of generation is transmitted to the PC machine by USB interface.
5. the full-automatic detector of xerophthalmia as claimed in claim 4, which is characterized in that the handle is hollow structure, described
The connecting line of probe assembly passes through the handle and connect with the analytical equipment, and the handle can be separated from the mancarried device
To make probe assembly independently use as handheld device；The head rest component setting passes through front and back at probe assembly rear
Swing the distance all around for adjusting hand lever to adjust adjustable bed component and probe assembly relative to head rest component,
By being rotated up and down upper and lower position of the Lower jaw support relative to probe assembly for adjusting hand lever to adjust head rest component.
6. the full-automatic detector of xerophthalmia as claimed in claim 5, which is characterized in that the data detecting unit includes tear film
Rupture time checks module, lacrimal river elevation carrection module, Meibomian gland Image Acquisition and enhancing module, lipid layer analysis module, institute
It states data detecting unit to connect by described image data acquisition unit with the camera module, described image data acquisition unit
Eyes image is exported in real time by video terminal, the output end of the data detecting unit is connect with the data analysis unit,
The data analysis unit will test report output by information management output unit.
7. the full-automatic detector of xerophthalmia as claimed in claim 6, which is characterized in that be provided with the first tear film on the handle
Rupture time review button, the first lacrimal river elevation carrection button, the first Meibomian gland Image Acquisition and enhancing button, the first lipid layer
Analysis button, each button and corresponding measurement pattern are corresponding, and every kind of measurement pattern corresponds to a kind of light illumination mode and imaging pattern.
8. the full-automatic detector of xerophthalmia as claimed in claim 7, which is characterized in that the signal input part of the PC machine is arranged
Have the second breakup time of tear film review button, the second lacrimal river elevation carrection button, the second Meibomian gland Image Acquisition and enhancing button,
Second lipid layer analysis button, each button and corresponding measurement pattern are corresponding, and every kind of measurement pattern corresponds to a kind of light illumination mode
And imaging pattern.
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| CN107960979B (en) * | 2017-12-29 | 2020-09-29 | 中国科学院苏州生物医学工程技术研究所 | Xerophthalmia detects illumination imaging system |
| CN110101359A (en) * | 2019-03-11 | 2019-08-09 | 中国科学院苏州生物医学工程技术研究所 | Novel xerophthalmia detection device |
| ES2834733A1 (en) * | 2020-11-24 | 2021-06-18 | Univ Madrid Complutense | Cyclotorsion Detection Device (Machine-translation by Google Translate, not legally binding) |
| CN113842109A (en) * | 2021-09-01 | 2021-12-28 | 四川大学华西医院 | Dry eye detection handheld imaging device and dry eye detection equipment |
| CN115836837B (en) * | 2023-02-20 | 2023-05-02 | 潍坊医学院附属医院 | Ophthalmic testing device |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070171365A1 (en) * | 2006-01-18 | 2007-07-26 | Visx, Incorporated | Non-invasive measurement of tear volume systems and methods |
| CN103799976A (en) * | 2014-03-04 | 2014-05-21 | 厦门大学 | Comprehensive diagnostic apparatus for xerophthalmia |
| CN104398234A (en) * | 2014-12-19 | 2015-03-11 | 厦门大学 | Comprehensive ocular surface analyzer based on expert system |
| CN104545793A (en) * | 2015-01-28 | 2015-04-29 | 厦门大学 | Noncontact-type tear film breakup time measuring device and method |
| US20150138505A1 (en) * | 2012-12-21 | 2015-05-21 | Tearscience, Inc. | Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography |
| CN104970766A (en) * | 2015-08-04 | 2015-10-14 | 上海莫视智能科技有限公司 | Tear digital imaging and objective analysis system |
| CN105595960A (en) * | 2015-12-17 | 2016-05-25 | 中国科学院苏州生物医学工程技术研究所 | Head-wearing dry eye detection device |
| CN105662343A (en) * | 2016-01-05 | 2016-06-15 | 中国科学院苏州生物医学工程技术研究所 | Dry eye detection and handheld imaging device and dry eye detection device and detection method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5386512B2 (en) * | 2009-01-30 | 2014-01-15 | 興和株式会社 | Ophthalmic imaging equipment |
| CN101818870A (en) * | 2010-02-03 | 2010-09-01 | 陈威翰 | LED lamp |
| CN206777303U (en) * | 2016-12-14 | 2017-12-22 | 中国科学院苏州生物医学工程技术研究所 | The full-automatic detector of xerophthalmia |
-
2016
- 2016-12-14 CN CN201611149801.XA patent/CN106510616B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070171365A1 (en) * | 2006-01-18 | 2007-07-26 | Visx, Incorporated | Non-invasive measurement of tear volume systems and methods |
| US20150138505A1 (en) * | 2012-12-21 | 2015-05-21 | Tearscience, Inc. | Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography |
| CN103799976A (en) * | 2014-03-04 | 2014-05-21 | 厦门大学 | Comprehensive diagnostic apparatus for xerophthalmia |
| CN104398234A (en) * | 2014-12-19 | 2015-03-11 | 厦门大学 | Comprehensive ocular surface analyzer based on expert system |
| CN104545793A (en) * | 2015-01-28 | 2015-04-29 | 厦门大学 | Noncontact-type tear film breakup time measuring device and method |
| CN104970766A (en) * | 2015-08-04 | 2015-10-14 | 上海莫视智能科技有限公司 | Tear digital imaging and objective analysis system |
| CN105595960A (en) * | 2015-12-17 | 2016-05-25 | 中国科学院苏州生物医学工程技术研究所 | Head-wearing dry eye detection device |
| CN105662343A (en) * | 2016-01-05 | 2016-06-15 | 中国科学院苏州生物医学工程技术研究所 | Dry eye detection and handheld imaging device and dry eye detection device and detection method thereof |
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