CN106510616A - Dry eye disease full-automatic detecting apparatus - Google Patents
Dry eye disease full-automatic detecting apparatus Download PDFInfo
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- CN106510616A CN106510616A CN201611149801.XA CN201611149801A CN106510616A CN 106510616 A CN106510616 A CN 106510616A CN 201611149801 A CN201611149801 A CN 201611149801A CN 106510616 A CN106510616 A CN 106510616A
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- xerophthalmia
- imaging
- button
- probe assembly
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0008—Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/101—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the tear film
Abstract
The invention discloses a dry eye disease full-automatic detecting apparatus, which comprises a probe assembly, a handle, a portable device and an analysis device, wherein the probe assembly comprises an imaging assembly, a lighting source, a camera module, a camera fixing device, a control board and a cover plate; the imaging assembly comprises an optical filter, a fixed sleeve and a conical drum; the conical drum is of an annular structure chequered with black and white; black rings are formed by conducting silk-screen printing with oil ink, and the oil ink is transmissive in infrared light and is non-transmissive in white light; one end of the handle is connected to the lower end of the probe assembly; the portable device comprises a base, a head supporting assembly, an adjusting handle rod and an adjustable workbench assembly; and the analysis device comprises an image data acquisition unit, a data detection unit and a data analysis unit. According to the detecting apparatus provided by the invention, the black annular structures on the conical drum is invisible to some infrared light while is visible to the white light, so that the demands of four imaging modes are satisfied; and it is unnecessary to detach the Placido conical drum when the detecting apparatus is used, so that a using process is simplified and the conical drum is prevented from getting lost easily.
Description
Technical field
The present invention relates to a kind of xerophthalmia testing equipment, particularly a kind of xerophthalmia fully-automated synthesis instrument.
Background technology
Xerophthalmia is referred under the tear quality and quantity exception that any reason causes or the extremely caused tear film stability of kinetics
Drop, and with ophthalmic uncomfortable, causes the general name of various diseases that ocular lesion tissue is characterized, also known as angle conjunctival xerosis.Often
See symptom include eyes it is dry and astringent, easily tired, ophthalmic pruritus, have foreign body sensation, pain burning sensation, sticky secretions, aversion to wind, photophobia, externally
Boundary stimulates very sensitive.One investigation in the U.S. shows that the adult of 10%-15% suffers from xerophthalmia, and Japan is 17%, Australia
For 10.3%, about in 21%-33.7%, current xerophthalmia sickness rate worldwide is in going up year by year for the xerophthalmia prevalence of China
The trend of liter, with the reasons such as the widely using of electronic curtain, ecological deterioration, the abuse of eye drop, the wearing of contact lenss, xerophthalmia
Disease will also continue to increase, and clinicist is badly in need of a kind of quick, portable, contactless, objective, quantitative, intelligence comprehensively xerophthalmia
Analytical equipment auxiliary diagnosis.Lacked according to two class of pathological characteristics xerophthalmia classification, including lipid shortage type xerophthalmia (LTD) and aqueous
Weary type xerophthalmia (ATD).The present invention can make comprehensive analysis result to xerophthalmia class, and auxiliary doctor is directed to different type and different journeys
The xerophthalmia of degree formulates individualized treatment scheme, improves therapeutic effect, reduces patient suffering.
Conventional xerophthalmia detection method mainly includes the breakup time of tear film detection of intrusive mood, Schimer's test at present
(as Schirmer I and II are tested), recently slit lamp examination and German OCULUS Keratograph 5M of release etc..Tradition
Breakup time of tear film (BUT) detection be corneal fluorescein sodium dyeing after under slit lamp microscope observe cornea occur first
The time of speckle is dried, inspection result accuracy depends on the stability of the experience and stain of observer to tear film；Lacrimal secretion
Test carries out tear measurement using standard testing strips, and the China and foreign countries 1/3 that two standard testing strips are gently put into conjunctival sac under tested eye are handed over
At boundary, patient looks down or gently closes one's eyes, and reagent paper is removed after 5 minutes, reads reagent paper scale, according to test value after placing one minute
Judge diagnostic result, the method also can be dripped in patient and basic value be tested with topical anesthesia state, it is to avoid reagent paper itself stimulates leads
The lacrimal secretion of cause affects the accuracy of result of the test, Schimer's test method be also the conventional method of current Clinical Ophthalmology it
One, low cost, but the test process persistent period is long, and the method for intrusive mood brings certain sense of discomfort to patient；Keratograph
5M can more fully analyze dry eye condition, but the equipment is larger, and portability is poor, relatively costly, and popularization is bad.
Meanwhile, the blackstreak part of the Placido rings in existing xerophthalmia analyser image-forming assembly is inked using conventional oil
Brush, after breakup time of tear film measurement terminates needs to remove Placido conically shapeds, then carries out lacrimal river elevation carrection, lipid layer
Image acquisition and tarsal glandss image acquisition, three kinds of measurements need to install Placido conically shapeds again after terminating, this design
Pattern undoubtedly brings certain trouble to operation doctor, and is easily lost after Placido conically shapeds are removed.
The content of the invention
For above-mentioned technical problem, the invention discloses a kind of xerophthalmia fully-automated synthesis instrument, the image-forming assembly is by filtering
Piece, fixes sleeve and conically shaped composition, Placido conically shaped ring design is chequered with black and white circulus, totally 10 ring, tear film
When rupture time inspection requirements is imaged, Placido rings are imaged chequered with black and white ring-type in photographing module, when checking for other three kinds then
It is imaged without the need for ring-type, therefore it is required that black annulus white light imaging is visible, infrared imaging is invisible, according to this imaging demand, black
Annulus selects specialty inks silk screen printing, it is ensured that black annulus imagewise uniform, and black ring-type is infrared to part not
It can be seen that, it is visible to white light, meet four kinds of imaging pattern demands, Placido conically shapeds during use, need not be removed, simplified using stream
Journey.This kind of specialty inks have passed through experimental verification, meet imaging requirements.
In order to realize these purposes of the invention and further advantage, there is provided a kind of xerophthalmia fully-automated synthesis instrument,
Including：
Probe assembly, image-forming assembly which includes setting gradually, lighting source, camera module, camera fixing device, control
Plate and cover plate, are provided with exit portal on the image-forming assembly, the lighting source and camera assembly are respectively aligned to the outgoing
Mouthful；The image-forming assembly includes optical filter, fixes sleeve and conically shaped, and the fixes sleeve is arranged to optically focused cavity configuration, institute
The big opening for stating laser pump cavity is directed at the exit facet of the lighting source, and the optical filter is arranged on the lighting source and laser pump cavity
Between light path on, the conically shaped is placido conically shaped, the little opening of the tapered end of the conically shaped from the laser pump cavity
Stretch in the laser pump cavity, the planar bottom end of the conically shaped is resisted against on the little opening of the laser pump cavity, the conically shaped is arranged
For chequered with black and white circulus, black ring and white ring totally 10 ring, black ring are formed by silk screening ink, and the ink is under infrared light
Transmissive, can not transmit under white light；
Handle, its first end are connected to the lower end of the probe assembly, and the handle is set to bendable structure；
Mancarried device, the handle are removably arranged on the mancarried device；And
Analytical equipment, which is integrated in PC, and the analytical equipment is communicated to connect with the probe assembly, the analysis dress
Put including image data acquiring unit, data detecting unit and data analysis unit.
Preferably, the lighting source is LED annular light sources, including circuit substrate and is evenly arranged on circuit substrate
Near-infrared LED, white light LEDs, circuit substrate adopt loop configuration, aluminium base material, and the near-infrared LED wavelength is 850nm, closely
Infrared LED and white light LEDs interval setting circularize light-source structure, be arranged concentrically some circles and be evenly arranged on the circuit substrate
Near-infrared LED and white light LEDs, near-infrared LED and white light LEDs are all independent drive and brightness is adjustable, the circuit substrate, filter
Mating plate and conically shaped center alignment offer through hole so as to form the exit portal of outside outgoing, and the exit portal alignment is suffered from
Person's eye.
Preferably, diffuse-reflectance coating, the emergent ray Jing of the lighting source are coated with the medial wall of the laser pump cavity
The diffuse-reflectance coating uniform is reflexed on the conical surface of the conically shaped.
Preferably, the camera module is high-resolution color module, supports the imaging of white light wave band, 850nm near-infrared ripples
Section imaging, supports auto-focusing, and focusing position is controllable, the camera module is configured with various corresponding with different measuring pattern
Imaging pattern, and the imaging pattern of camera module can be switched over by PC.
Preferably, the mancarried device includes base, head rest component, adjusts hand lever and adjustable bed component, described
Head rest component bottom is fixed on the base, and the adjustable bed component is movably arranged on described by the regulation hand lever
On base, the second end of the handle is detachably arranged on the adjustable bed component.
Preferably, the camera fixing device is cylindrical-shaped structure, and before and after the camera fixing device, both sides respectively offer
The cavity being interconnected, the optical filter, lighting source and camera module are successively set on the front side cavity from outside to inside
Interior, the laser pump cavity big opening of the fixes sleeve is fixed on the outside of the cavity of front side, and the panel is arranged in rear side cavity, and
The cover closure, the panel input is used to communicate to connect with PC by serial interface, the outfan of the panel
It is connected with the lighting source by light source control module, the camera module is imaged to patient's eye, and described in generating
Image is transmitted to the PC by USB interface.
Preferably, the handle is hollow-core construction, and the probe assembly connecting line is through the handle and the analysis dress
Connection is put, the handle can be separated into independent hand-held analytical equipment from the mancarried device；The head rest component sets
Put at probe assembly rear, by swing adjustable hand lever all around adjusting adjustable bed component and probe assembly phase
For the distance all around of head rest component, by rotating adjustable hand lever up and down come the Lower jaw support of adjustable head prop component relative to spy
The upper-lower position of head assembly.
Preferably, the data detecting unit includes that breakup time of tear film checks module, lacrimal river elevation carrection module, tarsus
Gland image acquisition and enhancing module, lipid layer analysis module, the data detecting unit pass through described image data acquisition unit
It is connected with the camera module, described image data acquisition unit exports eyes image, the data in real time by video terminal
Detector unit outfan is connected with the data analysis unit, and the data analysis unit will be examined by information management output unit
Survey report output.
Preferably, be provided with the handle the first breakup time of tear film review button, the first lacrimal river elevation carrection button,
First tarsal glandss image acquisition and enhancing button, the first lipid layer analysis button, each button are corresponding with corresponding measurement pattern,
A kind of corresponding light illumination mode of every kind of measurement pattern and imaging pattern.
Preferably, the PC signal input part is provided with the second breakup time of tear film review button, the second lacrimal river height
Measurement button, the second tarsal glandss image acquisition and enhancing button, the second lipid layer analysis button, each button and corresponding measurement
Pattern correspondence, a kind of corresponding light illumination mode of every kind of measurement pattern and imaging pattern.
The present invention at least includes following beneficial effect：
1st, the measurement device result is accurate, objective, stable, and the review time is short, can quickly be displayed in video terminal；
2nd, checking process of the present invention is non-intrusion type, reduces patient suffering, reduces and checks difficulty；
3rd, portable xerophthalmia analytical equipment portability of the invention is strong, and illumination and image-forming assembly design are ingenious, and polycrystalline substance is simultaneous
Hold crack modulated structure, it is especial patient inspection that can remove when using as handheld device, can also be placed on the lamp base of crack and use,
It is a kind of three kinds of usings method of design, not only facilitates doctor to operate, has also saved the valuable sky of ophthalmology clinic to a certain extent
Between resource；
4th, imaging system lighting source of the present invention is designed as multi-mode LED annular light source, there is provided uniform, stable, reliable
Infrared and white-light illuminating environment, light source and brightness it is adjustable, realize the automatic switchover of xerophthalmia checking mode；
5th, the design of device image-forming assembly is compact, and Placido tapered cartridge designs substitute existing Placido ring design, it is ensured that
Breakup time of tear film statistical accuracy while, realize the simplifying of Placido loop configuration；
6th, xerophthalmia Comprehensive Analysis Software system completes the diagnostic analysiss to four aspects of xerophthalmia, including during tear film rupture
Between check, lacrimal river elevation carrection.Tarsal glandss image taking and enhancing, lipid layer analysis；
7th, conical ring is arranged to into chequered with black and white circulus, black annulus specialty inks silk screen printing is protected
Card black annulus imagewise uniform, and black ring-type is infrared to part invisible, it is visible to white light, meet four kinds of imaging patterns
Demand, need not remove Placido conically shapeds, simplify and used flow process during use, conically shaped is not easy to lose.
Part is embodied by the further advantage of the present invention, target and feature by description below, and part will also be by originally
The research of invention and practice and be understood by the person skilled in the art.
Description of the drawings
Fig. 1 is the principle schematic of detector of the present invention；
Fig. 2 is the structural representation of probe assembly；
Fig. 3 is the structural representation of lighting source；
Fig. 4 is the structural representation of mancarried device；
Fig. 5 is the front view of conically shaped.
Specific embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings, to make those skilled in the art with reference to description text
Word can be implemented according to this.
It should be appreciated that it is used herein such as " have ", "comprising" and " including " term do not allot one or many
The presence or addition of individual other elements or its combination.
The invention discloses a kind of new xerophthalmia fully-automated synthesis instrument, including sample of high-resolution image module, intelligence
Light source control module, the probe assembly of Multifunction ring light source module composition, xerophthalmia Comprehensive Analysis Software analysis module, handle
And mancarried device, breakup time of tear film check-up through statistical means, lacrimal river elevation carrection are realized, tarsal glandss image acquisition strengthens and people's lema
The functions such as matter layer analysis, for clinical xerophthalmia diagnosis foundation is provided, be suitable for Clinical Ophthalmology diagnose its association area medical treatment answer
With, while by probe assembly miniaturization, can be only as portable equipment by whole xerophthalmia analytical equipment portability, probe assembly
It is vertical to use, take up room less, it is higher using the more convenient, suitability.
At present, the blackstreak part of Placido conical rings is printed using common ink, ties in breakup time of tear film measurement
Need to remove Placido conically shapeds after beam, then carry out lacrimal river elevation carrection, lipid layer image acquisition and tarsal glandss image and adopt
Collection, three kinds of measurements need to install Placido conically shapeds again after terminating, and this design pattern is undoubtedly brought to operation doctor
Certain trouble, and be easily lost after Placido conically shapeds are removed.The present invention is directed to the problems referred to above, it is proposed that a kind of new does
Eye disease fully-automated synthesis instrument, the conically shaped are set to chequered with black and white circulus, black ring and white ring totally 10 ring, and black ring is by oil
Black silk screen printing is formed, the ink under infrared light transmissive, can not transmit under white light, without the need for measuring in breakup time of tear film
Need to remove Placido conically shapeds after end, whole process can complete tear film rupture on the premise of Placido conically shapeds are not removed
Measure of time, lacrimal river elevation carrection, tarsal glandss image acquisition strengthen and human eye lipid layer analysis this 4 analytic functions, simplify
Operating process, improves detection efficiency, and conically shaped is not easy to lose.
Embodiment one
As shown in Fig. 1 a kind of way of realization of the invention, including：For the spy shot to patient's eye
The handle of head assembly and probe assembly integral structure, the mancarried device for carrying probe assembly, image is carried out it is multiple
The analysis system of symptom analysiss and by image, data, report output terminal.
In the present invention, probe assembly 4 is one and integrated is fixed by image-forming assembly, lighting source 44, camera module 45, camera
The integral structure of device 46, panel 47 and cover plate 48, as shown in Fig. 2 image-forming assembly, lighting source 44 and camera module
45 sides for being fixed on camera fixing device 46, the panel 47 are fixed on the opposite side of the camera fixing device 46, together
When, a complete structure is closed into cover plate 48, image-forming assembly includes conically shaped 41, fixes sleeve 42 and the filter for setting gradually
Mating plate 43, the fixes sleeve 42 are arranged to optically focused cavity configuration, respectively offer opening before and after laser pump cavity, and the laser pump cavity is opened greatly
Mouth is directed at the exit facet of the lighting source 44, and the optical filter 43 is arranged on the light between the lighting source 44 and laser pump cavity
Lu Shang, the conically shaped 41 are placido (Placido) conically shaped, and the tapered end of the conically shaped 41 is from the little of the laser pump cavity
Opening is stretched in the laser pump cavity so that whole conically shaped 41 is contained in the laser pump cavity with one heart, the conically shaped 41 it is flat
Bottom is resisted against on the little opening of the laser pump cavity, and the design of device image-forming assembly is compact, and Placido tapered cartridge designs substitute existing
Placido ring design, it is ensured that breakup time of tear film statistical accuracy while, realize simplifying for Placido loop configuration
Change, by whole probe assembly miniaturization, the size of last probe assembly 4 is reduced to diameter and length is 10cm or so, takes
Space is little, and the suitability is higher.
Meanwhile, as shown in figure 5, the conically shaped is set to chequered with black and white circulus, black ring and white ring totally 10 ring is black
Ring is formed by silk screening ink, the ink under infrared light transmissive, can not transmit under white light；Specifically, the present invention is right
The design of conically shaped is improved, and Placido conically shapeds ring design is chequered with black and white ring-type, totally 10 ring, relative to prior art,
Number of rings is reduced, the size of probe assembly is reduced, Placido rings are in photographing module when breakup time of tear film inspection requirements is imaged
Chequered with black and white ring-type is imaged, is then imaged without the need for ring-type when checking for other three kinds, therefore it is required that black annulus white light imaging is visible,
Infrared imaging is invisible, according to this imaging demand, black annulus we select specialty inks silk screen printing, it is ensured that black ring
Shape part imagewise uniform, and black ring-type is infrared to part invisible, it is visible to white light, meet four kinds of imaging pattern demands,
In detection process, Placido conically shapeds need not be removed, simplify and used flow process, improve detection efficiency, and conically shaped is difficult to lose
Lose.And this kind of specialty inks have passed through experimental verification, meet imaging requirements.
In the present embodiment, the camera fixing device 46 is both sides before and after cylindrical-shaped structure, the camera fixing device 46
The cavity being interconnected is offered respectively, the optical filter 43, lighting source 44 and camera module 45 are set gradually from outside to inside
In the front side cavity, the laser pump cavity big opening of the fixes sleeve 42 is fixed on the outside of the cavity of front side, and front side cavity is sealed
Close, the panel 47 is arranged in rear side cavity, and is closed with the cover plate 48, and 47 input of the panel passes through serial ports
Interface is communicated to connect with PC, and the outfan of the panel is connected with the lighting source 44 by light source control module, institute
State, the lighting source and camera assembly are respectively aligned to the outgoing
Mouthful, exit portal is directed at into eye, the camera module is imaged to patient's eye, and the described image for generating is passed through USB
Interface is transmitted to the PC.
The lighting source 44 adopt for LED annular light sources, as shown in figure 3, including circuit substrate 440 and being evenly arranged
Near-infrared LED 441, white light LEDs 442 on circuit substrate 440, circuit substrate 440 adopt loop configuration, aluminium base material,
The near-infrared LED wavelength is 850nm, and near-infrared LED and white light LEDs interval setting circularize light-source structure, the circuit base
Near-infrared LED and white light LEDs that two circles are evenly arranged are arranged concentrically on plate so as to which uniform irradiation is improved in eye
As quality, wherein, near-infrared LED independently can drive and brightness is adjustable, and white light LEDs independently can also drive and brightness is adjustable, into
As system illumination light source design is multi-mode LED annular light source, there is provided uniform, stable, reliable infrared and white-light illuminating ring
Border, light source and brightness it is adjustable, realize the automatic switchover of xerophthalmia checking mode.
47 input of the panel is communicated to connect with PC by serial interface, and the outfan of the panel 47 passes through
Light source control module is connected with the lighting source 44, and light source control module controls the light illumination mode of lighting source 44, specifically,
When carrying out breakup time of tear film check-up through statistical means, light illumination mode is adjusted to white light, adjusts the intensity of irradiation light；Carry out lacrimal river high
During degree measurement, white light is also adjusted to, and adjusts intensity of illumination；When the enhancing of tarsal glandss image acquisition is carried out, also it is adjusted to
White light, and adjust intensity of illumination；When carrying out human eye lipid layer analysis, near infrared light is adjusted to, adjusts intensity of illumination.
After the pattern that measures is selected, above-mentioned white light or near infrared light are switched over automatically, and the corresponding intensity of illumination of adjust automatically,
To adapt to different detection requirements.
The camera module 45 adopt for high-resolution color module, take pictures into for carrying out high definition to eye
Picture, supports the imaging of white light wave band, the imaging of 850nm near infrared bands, and supports auto-focusing, and focusing position is controllable, described to take the photograph
As module 45 is configured with various imaging patterns corresponding with different measuring pattern, camera module 45 is by USB interface and PC control
End connection processed, the eye high-definition image of shooting is transmitted to the PC, and imaging pattern can be cut by PC control end
Change, the PC signal input part be provided with the second review button of breakup time of tear film, the second lacrimal river elevation carrection button, second
Tarsal glandss image acquisition and enhancing button, the second lipid layer analysis button, when one of button is selected, lighting source 44
Light illumination mode automatically switches to corresponding illumination mode, meanwhile, 45 adjust automatically of camera module imaging pattern, and carry out it is automatically right
Jiao, carries out high definition imaging to eye.
Mancarried device, the mancarried device include head rest component 1, adjustable hand lever 2, adjustable bed component 3, probe group
4 lower end of part is provided with one handle, that is to say, that handle first end is connected to the lower end of the probe assembly 4, and the handle is arranged
For bendable structure, the relative position of probe assembly 4 and handle can be conveniently adjusted, the second end of handle passes through a dismountable part
It is arranged on the adjustable bed component 3, head rest component 1 is arranged on 4 rear of probe assembly, when patient is positioned at head rest component
After on 1, by swing adjustable hand lever 2 all around adjusting adjustable bed component 3 and probe assembly 4 relative to head rest
The distance all around of component 1, while by rotating adjustable hand lever 2 up and down come the upper bottom of the Lower jaw support of adjustable head prop component 1
Put, so as to adjust position of human eye so that the lighting source and camera module in probe assembly 4 is aligned with eye, is reached most
Good imaging effect, realizes quick image checking, improves detection efficiency, while by probe assembly miniaturization, by whole xerophthalmia
Analytical equipment portability, probe assembly can be independently operated, as portable equipment take up room it is less, using more convenient, applicable
Property is higher.
And
Analytical equipment, which is integrated in PC, and the analytical equipment is communicated to connect with the probe assembly, the analysis dress
Put including image data acquiring unit, data detecting unit and data analysis unit and information management output unit unit, institute
Stating data detecting unit includes that breakup time of tear film checks module, lacrimal river elevation carrection module, tarsal glandss image acquisition and enhancing
Module, lipid layer analysis module, the data detecting unit are connected with the camera module by described image data acquisition unit
Connect, described image data acquisition unit exports eyes image in real time by video terminal, the data detecting unit outfan with
Examining report is exported by the data analysis unit connection, the data analysis unit by information management output unit.
The PC signal input part is connected with the serial interface and USB interface by the communication module, is led to
Letter and data transfer, enter corresponding control light illumination mode and imaging pattern for handover measurement modes in parallel.Described image data
Collecting unit input is connected with the outfan of the camera module 45, and eyes image is transmitted to PC end, described image number
According to collecting unit outfan respectively with breakup time of tear film check module, lacrimal river elevation carrection module, tarsal glandss image acquisition and
Strengthen the connection of module, lipid layer analysis module and video terminal, the eyes image shot under each pattern is transmitted to corresponding
Detection module, meanwhile, the data analysis unit respectively with breakup time of tear film check module, lacrimal river elevation carrection module,
Tarsal glandss image acquisition and the module that strengthens, the connection of lipid layer analysis module outfan, the data that each module collection is produced are entered
Row is corresponding to be analyzed, and draws testing result.Meanwhile, video terminal directly displays the image of shooting, for intuitively showing and seeing
Analysis is examined, this analysis system measurement result is accurate, objective, stable, and the review time is short, can quickly be displayed in video terminal.
The outfan of the data analysis unit is connected with information management output unit, and the system is to four sides of xerophthalmia
The diagnostic analysiss in face, including breakup time of tear film inspection, lacrimal river elevation carrection, tarsal glandss image taking and enhancing, lipid layer point
Analysis, the data that these detections are generated production report, printout Jing after the process of information management output unit.Meanwhile, in PC
In storage carried out to view data and detection data stay shelves.
Specifically, the PC signal input part is provided with the second breakup time of tear film review button, the second lacrimal river height
Measurement button, the second tarsal glandss image acquisition and enhancing button, the second lipid layer analysis button, each button and corresponding measurement
Pattern correspondence, a kind of corresponding light illumination mode of every kind of measurement pattern and imaging pattern, under every kind of measurement pattern, adjust automatically illumination light
The imaging pattern of the light illumination mode and camera module 45 in source 44, when one of button is selected, the illumination mould of lighting source 44
Formula automatically switches to corresponding illumination mode, meanwhile, 45 adjust automatically of camera module imaging pattern, and auto-focusing is carried out, it is right
Eye carries out high definition imaging.The lighting source 44 is irradiated at patient's eye through the image-forming assembly, there is provided illumination, with
The camera module 45 carries out high definition imaging to patient's eye afterwards, and the described image of generation is transmitted to institute by USB interface
Stating PC carries out data analysiss and detection, and is stored and shown analysis, and checking process is non-intrusion type, reduces patient's pain
Hardship, reduces and checks difficulty.
Embodiment two
In the present embodiment, the handle be hollow-core construction, 4 connecting line of the probe assembly through the handle with described point
Analysis apparatus connect, and the handle can be separated into independent hand-held analytical equipment from the mancarried device；The head rest group
Part is arranged on probe assembly rear, by swing adjustable hand lever all around adjusting adjustable bed component and probe group
All around distance of the part relative to head rest component, it is relative come the Lower jaw support of adjustable head prop component by rotating adjustable hand lever up and down
In the upper-lower position of probe assembly.Specifically, handle, at its lower end is arranged on the adjustable bed group by a dismountable part
On part 3, head rest component 1 is arranged on 4 rear of probe assembly, after patient is positioned on head rest component 1, by swinging adjustable hand lever
2 all around adjusting the distance all around of adjustable bed component 3 and probe assembly 4 relative to head rest component 1, together
When by rotating adjustable hand lever 2 up and down come the upper-lower position of the Lower jaw support of adjustable head prop component 1, so as to adjust position of human eye, make
Lighting source in probe assembly 4 and camera module are aligned with eye, reach optimal imaging effect, realization quickly into
As detection, detection efficiency is improved, and portability is strong, adaptability is higher.
It is directed to some especial patients, it is impossible to be placed in the detection means from head is about to, in order to do for these patients
Eye detects that it is specific disease that the handle in the present embodiment can be disassembled from adjustable bed component 3 as handheld device
People checks that only need to can check handheld device alignment eye, patient can complete entirely to detect with recumbency
Journey, is that patient and operator provide convenient, and the handheld device can also be placed on the lamp base of crack and use, can deep space resources, can
A kind of meaning three kinds of usings method of design, for some inconvenience not only facilitate doctor to operate, have also saved ophthalmology to a certain extent and have examined
The valuable space resources in room.
Embodiment three
On the basis of embodiment one, when the portable equipment that probe assembly becomes independent is removed, in order to easy to operate,
The first breakup time of tear film review button, the first lacrimal river elevation carrection button, the first tarsal glandss figure are provided with the handle
As gathering and strengthening button, the first lipid layer analysis button, each button is corresponding with corresponding measurement pattern, every kind of measurement pattern
A kind of light illumination mode of correspondence and imaging pattern, when one of button is selected, the light illumination mode of lighting source 44 automatically switches
To corresponding illumination mode, meanwhile, 45 adjust automatically of camera module imaging pattern, and auto-focusing is carried out, eye is entered
Row high definition is imaged.Specifically, be respectively arranged with the button of control measurement pattern on the PC and on handle, each button with it is corresponding
Measurement pattern correspondence, a kind of light illumination mode of every kind of measurement pattern correspondence and imaging pattern, under every kind of measurement pattern, adjust automatically
The imaging pattern of the light illumination mode and camera module 45 of lighting source 44, when one of button is selected, lighting source 44
Light illumination mode automatically switches to corresponding illumination mode, meanwhile, 45 adjust automatically of camera module imaging pattern, and carry out it is automatically right
Jiao, carries out high definition imaging to eye.The lighting source 44 is irradiated at patient's eye through the image-forming assembly, there is provided shone
Bright, subsequently the camera module 45 carries out high definition imaging to patient's eye, and the described image for generating is transmitted by USB interface
Data analysiss and detection are carried out to the PC, and is stored and shown analysis, checking process is non-intrusion type, reduce patient
Pain, reduces and checks difficulty.When removing handle, when probe assembly becomes independent hand-held testing equipment, operator can be
The switching of measurement pattern is carried out on handle, so as to realize off line, independent operation, measurement efficiency and convenience is improve..
Example IV
On the basis of embodiment one or embodiment two, diffuse-reflectance coating, institute on the medial wall of the laser pump cavity, are coated with
Diffuse-reflectance coating uniform described in stating the emergent ray Jing of lighting source is reflexed on the conical surface of the conically shaped, and emergent light is met
The effectiveness of irradiation light on the conical surface of conically shaped, is enhanced, polarisation, light leak is reduced, so as to emergent light cover is in patient
Eye, there is provided preferably illuminating effect, and then raising imaging effect, improves accurate, the objective and stability of measurement result.
Embodiment five
On the basis of embodiment one, the circuit substrate 440, optical filter 45 and 41 center alignment of conically shaped are offered
Through hole, the taking lens of the camera module 45, by the through-hole alignment patient's eye, are that camera module 45 provides shooting light path,
Optimize imaging optical path, reduce the size of this probe assembly 4, by analysis system miniaturization, portability.
From the above mentioned, xerophthalmia comprehensive analysis device in the present invention, including sample of high-resolution image module, intelligent light source
Control module, Multifunction ring light source module, software module, data processing and control system meter and portable xerophthalmia comprehensive analysis dress
Put.Sample of high-resolution image module can gather coloured image and near-infrared image, and the automatic focusing function of acquisition module meets
Breakup time of tear film measures the imaging demands different from tarsal glandss image-forming principle；Multifunction ring light source module provides illumination ring
Border, is connected with PC by serial communication, and host computer realizes intelligent light source control module by software, realizes uniform infrared photograph
Bright environment and white-light illuminating environment, realize breakup time of tear film check-up through statistical means, lacrimal river elevation carrection, and tarsal glandss image acquisition strengthens
And the function such as human eye lipid layer analysis.
Simultaneously the xerophthalmia overall analysis system of the present invention include colored sense infrared photography module, LED ring illumination light sources,
Panel, portable xerophthalmia comprehensive analysis device and xerophthalmia overall analysis system module.Wherein camera module, ring illumination light
Source and panel are integrated in inside mancarried device, and panel realizes intelligent light source control function, control annular light source illumination system
System, there is provided multi-mode lighting environment, is obtained view data by camera module, is transmitted to PC by USB interface, and Jing PC xerophthalmia is comprehensive
Close analysis system module analysis to calculate and include result in PC video terminals, and diagnosis report can be exported by end print.
Mancarried device includes head rest component, adjustable bed component, adjustable hand lever, probe assembly, display screen, notebook
Computer etc..The position around of adjustable bed, and the upper-lower position of Lower jaw support are adjusted by adjustable hand lever, so as to reality
Existing quickly and accurately pupil alignment function；Instrument host is connected with notebook computer by the USB3.0 interfaces of bottom, is realized
Mutual communication and correlation function are realized.Probe assembly is mainly by Placido conically shapeds, fixes sleeve, annular light source, CCD phases
Machine, camera fixing device etc. are constituted, and structure design is conveniently removed and installed.
Imaging system includes camera module, LED annular light sources, probe assembly, panel and USB device interface, wherein taking the photograph
As module, LED annular light sources and panel are integrated in inside imaging system device, camera module is connected with PC, and panel connects
Annular light source is connect, light source control is realized by PC Communication, be responsible for the control of signal and the input and output of data by PC.
Xerophthalmia Comprehensive Analysis Software system module is arranged in PC ends, and the image of camera module collection is carried out showing, stored and related
Resume module, and measurement result is carried out showing, stored and printout.The brightness of the annular light source inside appliance imaging system
Adjust and light source switch control is signaled to give input, software system to be used to carry out process image data acquiring, scheme by PC sections
As data analysiss judgement and the output of diagnostic result.
Circuit of light sources adopts loop configuration, aluminium base material, near-infrared LED wavelength to meet imaging requirements for 850nm.Annular
Light source design two is enclosed, and infrared LED and the alternate aluminium base two that is evenly arranged in of white light LEDs are enclosed, it is ensured that brightness of illumination is uniform.It is infrared
Light source design is that brightness is adjustable, and it is adjustable that white light source is designed as brightness.
Mancarried device includes head rest component 1, adjustable hand lever 2, adjustable bed component 3, probe assembly 4.By adjustable
Hand lever can adjust the position around of adjustable bed, and the upper-lower position of Lower jaw support, so as to adjust position of human eye,
Reach optimal imaging effect.
Probe assembly 4 by Placido conically shapeds 41, fixes sleeve 42, optical filter 43, annular light source 44, camera module 45,
Camera fixing device 46, control board 47 and cover plate 48 are constituted.Probe assembly lower support structure is compatible with slit lamp, uses
When can be placed on crack lamp base, can also take off hand-held use.
Camera module selects high-resolution color module, supports the imaging of 850nm near infrared bands, supports auto-focusing, right
Burnt position is controllable.Imaging pattern is controlled by PC ends software.
Xerophthalmia Comprehensive Analysis Software system is arranged in PC, is connected with constructional device by Serial Port Line and USB, realizes logical
Letter and data interaction.Xerophthalmia Comprehensive Analysis Software system includes communication module, image data acquiring unit, breakup time of tear film inspection
Look into module, lacrimal river elevation carrection module, tarsal glandss image acquisition and strengthen module, data analysis module and information management output mould
Block, finally realizes xerophthalmia comprehensive analysis function.
Placido conically shapeds are designed for breakup time of tear film inspection, and during inspection, those who are investigated are placed on head under head rest 1
At jaw, operation doctor is adjusted by adjustable hand lever 2 and causes human eye (left eye or right eye) to be directed at imaging center, and measured's eyes are just
Depending on front, normally twinkle after the site alignment pupil of center, then enjoin measured to open eyes always and recorded out until system automatically
Tear film rupture time and site first.Measurement again needs rest at least 1 minute of closing one's eyes, data analysis module to support repeatedly to measure
Repeatedly record, facilitate doctor's statistical analysiss state of an illness；After breakup time of tear film inspection terminates, lacrimal river elevation carrection can be carried out, first
Operation doctor need not remove Placido conically shapeds, and measured is placed on head at 1 lower jaw of head rest, operate tear of the doctor to patient
River image is captured, and the lacrimal river immediately below pupil central authorities is highly measured with the survey tool of software system；Tarsus
Gland image acquisition includes upper eyelid and palpebra inferior tarsal glandss infrared imaging, is strengthened by software system and is analyzed and processed, and aids in doctor
Clinical dry eye diagnostic；Lipid layer is parsed into picture, after enjoining measured to twinkle, captures human eye lipid tomographic image.Four kinds of patterns into
As system is realized automatically switching by the software system at PC ends, the illness analyses of xerophthalmia are completed, is then taken for the cause of disease
Individualized treatment scheme, for clinicist provide it is a kind of directly, it is quick, write, noinvasive, objective, comprehensive diagnosis basis are with auxiliary
Xerophthalmia is helped to diagnose.
The system and measurement device result are accurate, objective, stable, and the review time is short, can quickly be displayed in video terminal；And
Whole checking process is non-intrusion type, reduces patient suffering, reduces and checks difficulty；Take formula xerophthalmia analytical equipment portability strong, shine
The design of bright and image-forming assembly is ingenious, polycrystalline substance compatibility crack modulated structure, and it is specific disease that can remove when using as handheld device
People's inspection, can also be placed on the lamp base of crack and use, and be a kind of three kinds of usings method of design, not only facilitate doctor to operate,
The valuable space resources of ophthalmology clinic has been saved to a certain extent；Imaging system lighting source of the present invention is designed as multi-mode LED
Annular light source, there is provided uniform, stable, reliable infrared and white-light illuminating environment, light source and brightness it is adjustable, realize xerophthalmia inspection
Look into the automatic switchover of pattern；, the design of device image-forming assembly it is compact, Placido tapered cartridge designs substitute existing Placido rings and set
Meter, it is ensured that breakup time of tear film statistical accuracy while, realize the simplifying of Placido loop configuration；Conical ring is set
It is set to chequered with black and white circulus, black annulus specialty inks silk screen printing, it is ensured that the imaging of black annulus is equal
It is even, and black ring-type is infrared to part invisible, it is visible to white light, meet four kinds of imaging pattern demands, need not remove during use
Placido conically shapeds, have simplified and have used flow process, and conically shaped is not easy to lose.Xerophthalmia Comprehensive Analysis Software system is completed to xerophthalmia
The diagnostic analysiss of four aspects of disease, including breakup time of tear film inspection, lacrimal river elevation carrection, tarsal glandss image taking and enhancing,
Lipid layer analysis.
Although embodiment of the present invention is disclosed as above, which is not restricted to listed by description and embodiment
With, it can be applied to various suitable the field of the invention completely, for those skilled in the art, can be easily
Other modification is realized, therefore under the general concept limited without departing substantially from claim and equivalency range, the present invention is not limited
In specific details and shown here as the legend with description.
Claims (10)
1. a kind of xerophthalmia fully-automated synthesis instrument, it is characterised in that include：
Probe assembly, image-forming assembly which includes setting gradually, lighting source, camera module, camera fixing device, panel with
And cover plate, exit portal is provided with the image-forming assembly, the lighting source and camera assembly are respectively aligned to the exit portal；Institute
Stating image-forming assembly includes optical filter, fixes sleeve and conically shaped, and the fixes sleeve is arranged to optically focused cavity configuration, the optically focused
The big opening in chamber is directed at the exit facet of the lighting source, and the optical filter is arranged between the lighting source and laser pump cavity
In light path, the conically shaped is placido conically shaped, and the tapered end of the conically shaped stretches into institute from the little opening of the laser pump cavity
State in laser pump cavity, the planar bottom end of the conically shaped is resisted against on the little opening of the laser pump cavity, and the conically shaped is set to black and white
Alternate circulus, black ring and white ring totally 10 ring, black ring are formed by silk screening ink, and the ink can be saturating under infrared light
Penetrate, can not transmit under white light；
Handle, its first end are connected to the lower end of the probe assembly, and the handle is set to bendable structure；
Mancarried device, the handle are removably arranged on the mancarried device；And
Analytical equipment, which is integrated in PC, and the analytical equipment is communicated to connect with the probe assembly, the analytical equipment bag
Include image data acquiring unit, data detecting unit and data analysis unit.
2. xerophthalmia fully-automated synthesis instrument as claimed in claim 1, it is characterised in that the lighting source is LED ring lights
Source, including circuit substrate and the near-infrared LED being evenly arranged on circuit substrate, white light LEDs, circuit substrate adopt ring junction
Structure, aluminium base material, the near-infrared LED wavelength are 850nm, and near-infrared LED and white light LEDs interval setting circularize light source knot
Structure, is arranged concentrically some near-infrared LEDs and white light LEDs, near-infrared LED and white light for enclosing and being evenly arranged on the circuit substrate
LED be all it is independent drive and brightness is adjustable, the circuit substrate, optical filter and conically shaped center alignment offer through hole so as to
The exit portal of outside outgoing is formed, the exit portal is directed at eye.
3. xerophthalmia fully-automated synthesis instrument as claimed in claim 2, it is characterised in that coat on the medial wall of the laser pump cavity
There is diffuse-reflectance coating, diffuse-reflectance coating uniform described in the emergent ray Jing of the lighting source reflexes to the conical surface of the conically shaped
On.
4. xerophthalmia fully-automated synthesis instrument as claimed in claim 3, it is characterised in that the camera module is that high-resolution is color
Color module, supports the imaging of white light wave band, the imaging of 850nm near infrared bands, supports auto-focusing, and focusing position is controllable, described
Camera module is configured with various imaging patterns corresponding with different measuring pattern, and the imaging pattern of camera module can pass through PC
Switch over.
5. xerophthalmia fully-automated synthesis instrument as claimed in claim 4, it is characterised in that the mancarried device include base,
Head rest component, regulation hand lever and adjustable bed component, the head rest component bottom are fixed on the base, the adjustable work
Make platform component to be movably arranged on the base by the regulation hand lever, the second end of the handle is detachably arranged in described
On adjustable bed component.
6. xerophthalmia fully-automated synthesis instrument as claimed in claim 5, it is characterised in that the camera fixing device is cylindric
Structure, before and after the camera fixing device, both sides respectively offer the cavity being interconnected, and the optical filter, lighting source and take the photograph
As module is successively set in the front side cavity from outside to inside, the laser pump cavity big opening of the fixes sleeve is fixed on front side sky
On the outside of chamber, the panel is arranged in rear side cavity, and uses the cover closure, and the panel input is connect by serial ports
Mouth and PC communication connection, the outfan of the panel is connected with the lighting source by light source control module, described to take the photograph
As module is imaged to patient's eye, and the described image of generation is transmitted to the PC by USB interface.
7. xerophthalmia fully-automated synthesis instrument as claimed in claim 6, it is characterised in that the handle is hollow-core construction, described
Probe assembly connecting line is connected through the handle with the analytical equipment, and the handle can be separated into from the mancarried device
For independent hand-held analytical equipment；The head rest component is arranged on probe assembly rear, before and after swinging adjustable hand lever
Left and right adjusting the distance all around of adjustable bed component and probe assembly relative to head rest component, by rotating up and down
Adjustable hand lever carrys out the upper-lower position of the Lower jaw support relative to probe assembly of adjustable head prop component.
8. xerophthalmia fully-automated synthesis instrument as claimed in claim 7, it is characterised in that the data detecting unit includes tear film
Rupture time checks module, lacrimal river elevation carrection module, tarsal glandss image acquisition and strengthens module, lipid layer analysis module, institute
State data detecting unit to be connected with the camera module by described image data acquisition unit, described image data acquisition unit
Eyes image is exported in real time by video terminal, the data detecting unit outfan is connected with the data analysis unit, institute
State data analysis unit to export examining report by information management output unit.
9. xerophthalmia fully-automated synthesis instrument as claimed in claim 8, it is characterised in that the first tear film is provided with the handle
Rupture time review button, the first lacrimal river elevation carrection button, the first tarsal glandss image acquisition and enhancing button, the first lipid layer
Analysis button, each button are corresponding with corresponding measurement pattern, and every kind of measurement pattern corresponds to a kind of light illumination mode and imaging pattern.
10. xerophthalmia fully-automated synthesis instrument as claimed in claim 9, it is characterised in that the PC signal input part is arranged
Have the second breakup time of tear film review button, the second lacrimal river elevation carrection button, the second tarsal glandss image acquisition and strengthen button,
Second lipid layer analysis button, each button are corresponding with corresponding measurement pattern, a kind of corresponding light illumination mode of every kind of measurement pattern
And imaging pattern.
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| CN106510616B (en) | 2019-05-28 |
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