CN107960979A - A kind of xerophthalmia detects illumination imaging systems - Google Patents
A kind of xerophthalmia detects illumination imaging systems Download PDFInfo
- Publication number
- CN107960979A CN107960979A CN201711479540.2A CN201711479540A CN107960979A CN 107960979 A CN107960979 A CN 107960979A CN 201711479540 A CN201711479540 A CN 201711479540A CN 107960979 A CN107960979 A CN 107960979A
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- Prior art keywords
- xerophthalmia
- optical system
- imaging systems
- tear film
- placido
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0008—Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B13/00—Optical objectives specially designed for the purposes specified below
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
- G03B15/00—Special procedures for taking photographs; Apparatus therefor
- G03B15/02—Illuminating scene
Abstract
The invention discloses a kind of xerophthalmia to detect illumination imaging systems, it includes：Placido disks, it includes several chequered with black and white donuts；Lamp optical system, it is arranged on the Placido disks rear surface, and the lamp optical system includes some groups of LED units arranged in a ring, the Placido disks are projected to tear film；Imaging optical system, it receives the Placido disk perspective views in the tear film, and along imaging optical path, the imaging optical system includes image-forming objective lens and CCD camera successively.The present invention can gather examinate's ocular surface tear film by the complete a series of pictures to during rupture in a manner of non-intrusive, then post-processed again through image algorithm, it can draw breakup time of tear film, so as to regard to that can judge whether examinate's breakup time of tear film is abnormal, technical solution of the present invention can not only reduce patient suffering, but also improve the stability and accuracy of testing result.
Description
Technical field
The present invention relates to field of optical detection.A kind of it is more particularly related to xerophthalmia detection illumination imaging system
System.
Background technology
Xerophthalmia, also known as angle xerosis of conjunctiva, common sympton include eyes it is dry and astringent, easily tired, eye itch, have foreign body sensation,
Pain burning heat sensation, secretion are sticky, fear of wind, photophobia, very sensitive etc. to environmental stimuli, and the dry eyes illness rate in China is about in 21%-
33.7%, the incidence of dry eyes worldwide is in ascendant trend year by year at present, has developed into and a kind of jeopardizes the normal of health
See disease, frequently-occurring disease.With originals such as the widely using of electronic curtain, the wearings of the abuse of environmental degradation, eye drops, contact lenses
Cause, xerophthalmia will also continue to increase.The main reason for causing xerophthalmia is that the abnormal of ocular tear film ruptures, correlative study article table
Bright, Lacrimal Film of Xeroma Patients rupture time is usually less than 10s, and normal eye's breakup time of tear film is generally 10-45s.Tear film
Rupture time length is to judge whether an important indicator with xerophthalmia, therefore accurately and effectively detects the rupture of tear film
Inspection of the time to xerophthalmia has great significance.
The inspection method of traditional xerophthalmia has：Slit lamp examination, Schimer's test (Schirmer I and II test),
Breakup time of tear film (Tear Break-up Time, BUT) experiment, the experiment of ocular visitain, the experiment of tear osmometry,
Lactoferrin content measure (Lactoferrin, LF) experiment, the experiment of tear Ferning, conjunctival impression cell test inspection, serology
Check etc..The method of these Traditional measurements tear film stabilities is the property invaded breakup time of tear film (invasive tear break-
Up time, IBUT), have variability big, repeatability is low, easily by limitations such as ectocines.
The content of the invention
It is excellent it is an object of the invention to solve at least the above and/or defect, and provide at least to will be described later
Point.
It is a still further object of the present invention to provide a kind of xerophthalmia to detect illumination imaging systems, it can be with non-intrusive side
Formula gathers examinate's ocular surface tear film by the complete a series of pictures to during rupture, is then handled through image algorithm, you can
Breakup time of tear film is drawn, so that with regard to that can judge whether examinate's breakup time of tear film is abnormal.
In order to realize these purposes and further advantage according to the present invention, there is provided a kind of xerophthalmia detection illumination imaging system
System, it includes：
Placido disks, it includes several chequered with black and white donuts, wherein white is light transmission part, black is not
Light transmission part；
Lamp optical system, it is arranged on the Placido disks rear surface, and the lamp optical system is in ring including some groups
The LED unit of shape arrangement, the black and white strip on the Placido disks is projected to tear film, wherein LED lamp bead circularize arrangement can
To significantly improve the even light effect of illumination；
Imaging optical system, it receives the Placido disk perspective views in the tear film, along imaging optical path, the imaging
System includes image-forming objective lens and CCD camera successively.
Preferably, wherein, acrylic light diffusing sheet is additionally provided between the lamp optical system and Placido disks,
To further improve the homogeneous diffusivity of lighting source.The illumination of uniform source of light can cause the black and white strip in Placido disks
Light and dark donut is formed, improves the contrast of imaging.
Preferably, wherein, spacing between the lamp optical system and the acrylic light diffusing sheet for 7~
15cm, to realize the diffusion effect optimal to LED light source.
Preferably, wherein, the Placido disks design for elliposoidal, to improve the brightness of CCD cell imagings.
Preferably, wherein, the lamp optical system includes four groups of LED units arranged in a ring, to realize irradiation
The uniform diverging of light intensity.
Preferably, wherein, every group of LED unit is made of the LED lamp bead equidistantly arranged, and the LED lamp bead is
Wavelength is the infrared LED lamp bead of 850nm.Due to when xerophthalmia detects Image Acquisition be it is continuous gather for a long time, in order to reduce pair
The stimulation of human eye, selects infrared LED lamp bead of the wavelength for 850nm.
Preferably, wherein, the angle of divergence of the infrared LED lamp bead is 150 °, to ensure the brightness of Placido disks imaging
Homogeneity.
Preferably, wherein, along inner ring to outer ring, the arrangement spacing between four groups of annular LED units is 1：1~1.5：
0.3~0.7, to ensure the uniform diverging of illumination intensity.
Preferably, wherein, along imaging optical path, the image-forming objective lens include successively：First planoconvex spotlight, its convex surface facing
Object space；Concavees lens；Convex lens；Second planoconvex spotlight, it is convex surface facing object space；And meniscus lens, it is imaged convex surface facing object space
Object lens can effectively correct the aberrations such as spherical aberration, astigmatism and the curvature of field by the combination of 5 lens units, improve image quality；
Wherein, diaphragm is arranged between first planoconvex spotlight and concavees lens and close to the position of concavees lens, close to diaphragm
The eyeglasses of concavees lens bend towards diaphragm so that chief ray drift angle is as far as possible small, beneficial to the correction of off-axis aberration.
Preferably, the concavees lens and convex lens are glued together, and to correct aberration, wherein balsaming lens can be selected
The larger glass material of dispersion differences, can effectively reduce axial chromatic aberration.
The present invention includes at least following beneficial effect：
(1) technical scheme is the method for inspection using the non-intrusion type based on Placido disks, can both reduce patient
Pain, and improve the stability and accuracy of testing result；
(2) the photo optical system of present specification is designed using LED annular arrangements, and to some groups of LED units and
Lamp bead therein carries out Rational Arrangement, is remarkably improved the uniform diverging of lighting source, improves adjacent black in the imaging of Placido disks
The contrast of informal voucher line；
(3) in present specification imaging optical system object lens by the combination of 5 lens units can effectively correct spherical aberration, as
The aberrations such as the scattered and curvature of field, and concavees lens therein and convex lens are glued together, to correct aberration, significantly improve imaging
Quality.
Further advantage, target and the feature of the present invention embodies part by following explanation, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Brief description of the drawings
Fig. 1 is the structure diagram that xerophthalmia detects illumination imaging systems in an example of the present invention；
Fig. 2 is the structure diagram that LED unit is arranged in a ring in another examplatory illumination optical system of the invention；
Fig. 3 is the structure diagram of object lens in another example imaging optical system of the invention；
Fig. 4 is the point range signal verified in another example of the present invention using zemax softwares to imaging optical system
Figure；
Fig. 5 is the modulation transmission verified in another example of the present invention using zemax softwares to imaging optical system
Function (MFT) figure；
Fig. 6 is the curvature of field distortion verified in another example of the present invention using zemax softwares to imaging optical system
Figure；
Fig. 7 is the wave aberration figure verified in another example of the present invention using zemax softwares to imaging optical system；
Fig. 8 is to use xerophthalmia to detect projection of the illumination imaging systems to human eye surface's tear film in another example of the present invention
Image.
In figure：1-Placido disks；2- lamp optical systems；3- tear films；4- image-forming objective lens；5-CCD cameras；6- acrylics
Light diffusing sheet；21-LED lamp beads；The first planoconvex spotlights of 41- 41；42- concavees lens；43- convex lenses；The second planoconvex spotlights of 44-；45-
Meniscus lens；46- diaphragms.
Embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings, to make those skilled in the art with reference to specification text
Word can be implemented according to this.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein do not allot one or more
The presence or addition of a other elements or its combination.
Fig. 1~2 show a kind of way of realization according to the present invention, including：.
Placido disks 1, it includes several chequered with black and white donuts；
Lamp optical system 2, it is arranged on the Placido disks rear surface, and the lamp optical system is in including some groups
The LED unit of annular arrangement, the Placido disks are projected to tear film 3；
Imaging optical system, it receives the Placido disk perspective views in the tear film, along imaging optical path, the imaging
System includes image-forming objective lens 4 and CCD camera 5 successively.
In this technical solution, LED illumination optical system illuminates Placido disks, and black and white strip is alternate
The picture of Placido disks is projected in human eye tear film, and then light is reflected by tear film, by image-forming objective lens, by surface of tear-film image
It is imaged in CCD camera.When the complete crack-free of the upper tear film of human eye surface, in human eye surface's tear film for being collected in CCD camera
Chequered with black and white annulus be it is complete coaxial circular, when the tear film rupture on human eye surface, people that CCD camera collects
Chequered with black and white annulus on tears film is rupture distortion.Examinate's ocular surface tear film is collected according to CCD camera
By the complete a series of pictures to during rupture, then by image algorithm subsequent treatment, you can breakup time of tear film is drawn, so that just
It can judge whether examinate's breakup time of tear film is abnormal.
In another example, acrylic light diffusing sheet 6 is additionally provided between the lamp optical system and Placido disks,
To further improve the diffusion homogeneity of lighting source.Also, this mode is a kind of explanation of preferred embodiments, but not office
It is limited to this.When implementing the present invention, the aspect of lamp optical system diffusion facilities can be implemented according to user's demand.
In another example, the spacing between the lamp optical system and the acrylic light diffusing sheet is 7~15cm.
In another example, the Placido disks design for elliposoidal, also, this mode is a kind of preferred embodiments
Explanation, but be not limited thereto.
In another example, four groups of LED units arranged in a ring are included with reference to Fig. 2, the lamp optical system.And
And this mode is a kind of explanation of preferred embodiments, but it is not limited thereto., can be according to use when implementing the present invention
Person's demand implements the different aspects of lamp optical system.
In examples detailed above, every group of LED unit is made of the LED lamp bead 21 equidistantly arranged, and the LED lamp bead is ripple
The infrared LED lamp bead of a length of 850nm.
In examples detailed above, the angle of divergence of the infrared LED lamp bead is 150 °.
In examples detailed above, along inner ring to outer ring, the arrangement spacing between four groups of annular LED units is 1：1~1.5：0.3~
0.7。
Placido disks are irradiated using the lamp optical system of this example, using disk center as the center of circle, in each white ring
Front surface (close to human eye side) with brightness value of spectrometer measurement, obtains the brightness value of 44 points, measurement data every 90 °
1 is shown in Table, brightness value uniformity can be calculated as 88.8% by table 1, this shows to use this examplatory illumination Optical System Design can be with
Placido disks rear surface is illuminated than more uniform, meets system imaging demand below.
1 Placido disk illuminations actually measured values of table
In another example, include successively with reference to Fig. 3, the image-forming objective lens 4：First planoconvex spotlight 41, its convex surface facing
Object space；Concavees lens 42；Convex lens 43；Second planoconvex spotlight 44, it is convex surface facing object space；Meniscus lens 45, it is convex surface facing object space；
Wherein, diaphragm 46 is arranged between first planoconvex spotlight and concavees lens and close to the position of concavees lens.
Also, this mode is a kind of explanation of preferred embodiments, but is not limited thereto., can when implementing the present invention
With the different aspects for object lens of being imaged according to user's demand.
In examples detailed above, with reference to Fig. 3, the concavees lens and convex lens are glued together.Also, this mode is one kind
The explanation of preferred embodiments, but be not limited thereto.
With reference to Fig. 3~7, the imaging system of this example is verified using in zemax softwares, is selected in zemax softwares
It is respectively tetra- visual fields of 0mm, 4.5mm, 6.3mm, 9mm to take half thing of object space high.As shown in figure 4, the root mean square (RMS value) of disc of confusion
Ccd pixel dimension 5.5um are respectively less than in each visual field, and each value is all close to Aili spot size；Fig. 5 show system
MTF curve, it is seen that be that full filed mtf value is more than 0.4 at 91lp/mm in spatial frequency values, and MTF curve connects
Nearly diffraction limit；Fig. 6 is system curvature of field distortion figure, it can be seen from the figure that the curvature of field is not more than 0.04mm in full filed maximum,
Full filed maximum distortion is not more than 0.8%；Fig. 7 be system wave aberration figure, Tu Zhong maximums field of view 9mm place peak-to-valley ratio be 0.17
Wavelength, less than 0.25 wavelength of Rayleigh criterion.From the foregoing, it will be observed that the system has good image quality, design requirement is reached.
In another example, the concrete application with reference to present specification technical solution in the detection of human eye surface's tear film, into
One step illustrates the present invention：
The perspective view in tear film collected with reference to Fig. 8, the xerophthalmia detection imaging system prepared using the technical program
Piece is regular concentric circles, it is seen that the perspective view of Placido rings is regular concentric circles in ocular, it can thus be appreciated that surface of tear-film annulus is bright
It is relatively good to spend uniformity, has obtained the perspective view of the second best in quality surface of tear-film Placido disks.
Number of devices and treatment scale described herein are the explanations for simplifying the present invention.To the xerophthalmia of the present invention
Detect the application of illumination imaging systems, modifications and variations will be readily apparent to persons skilled in the art.
As described above, according to the present invention, it can gather examinate's ocular surface tear film by complete in a manner of non-intrusive
The whole a series of pictures to during rupture, can not only reduce patient suffering, but also improve the stability and accuracy of testing result.
Although embodiment of the present invention is disclosed as above, it is not restricted in specification and embodiment listed
With.It can be applied to various suitable the field of the invention completely., can be easily for those skilled in the art
Realize other modification.Therefore it is of the invention and unlimited under the universal limited without departing substantially from claim and equivalency range
In specific details and shown here as the legend with description.
Claims (10)
1. a kind of xerophthalmia detects illumination imaging systems, it is characterised in that including：
Placido disks, it includes several chequered with black and white donuts；
Lamp optical system, it is arranged on the Placido disks rear surface, and the lamp optical system is arranged in a ring including some groups
The LED unit of cloth, the Placido disks are projected to tear film；
Imaging optical system, it receives the Placido disk perspective views in the tear film, along imaging optical path, the image optics system
System includes image-forming objective lens and CCD camera successively.
2. xerophthalmia as claimed in claim 1 detects illumination imaging systems, it is characterised in that in the lamp optical system and
Acrylic light diffusing sheet is additionally provided between Placido disks.
3. xerophthalmia as claimed in claim 2 detects illumination imaging systems, it is characterised in that the lamp optical system and institute
It is 7~15cm to state the spacing between acrylic light diffusing sheet.
4. xerophthalmia as claimed in claim 1 detects illumination imaging systems, it is characterised in that the Placido disks are ellipsoid
Shape designs.
5. xerophthalmia as claimed in claim 1 detects illumination imaging systems, it is characterised in that the lamp optical system includes
Four groups of LED units arranged in a ring.
6. xerophthalmia as claimed in claim 1 detects illumination imaging systems, it is characterised in that every group of LED unit by etc.
The LED lamp bead composition of spacing arrangement, the LED lamp bead is the infrared LED lamp bead that wavelength is 850nm.
7. xerophthalmia as claimed in claim 5 detects illumination imaging systems, it is characterised in that the hair of the infrared LED lamp bead
It is 150 ° to dissipate angle.
8. xerophthalmia as claimed in claim 5 detects illumination imaging systems, it is characterised in that along inner ring to outer ring, four groups of rings
The arrangement spacing of shape LED unit is 1：1~1.5：0.3~0.7.
9. xerophthalmia as claimed in claim 1 detects illumination imaging systems, it is characterised in that along imaging optical path, the imaging
Object lens include successively：First planoconvex spotlight, it is convex surface facing object space；Concavees lens；Convex lens；Second planoconvex spotlight, its convex surface court
To object space；And meniscus lens, it is convex surface facing object space；
Wherein, diaphragm is arranged between first planoconvex spotlight and concavees lens and close to the position of concavees lens.
10. xerophthalmia as claimed in claim 9 detects illumination imaging systems, it is characterised in that the concavees lens and convex lens
It is glued together.
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| CN201711479540.2A CN107960979B (en) | 2017-12-29 | 2017-12-29 | Xerophthalmia detects illumination imaging system |
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| CN109758112A (en) * | 2019-02-25 | 2019-05-17 | 北京大学第三医院 | A kind of cornea curvimeter |
| CN110101359A (en) * | 2019-03-11 | 2019-08-09 | 中国科学院苏州生物医学工程技术研究所 | Novel xerophthalmia detection device |
| CN110367926A (en) * | 2019-07-22 | 2019-10-25 | 天津市索维电子技术有限公司 | A kind of xerophthalmia check device and method applied to self-medicine |
| CN111062443A (en) * | 2019-12-20 | 2020-04-24 | 浙江大学 | Tear film rupture time detecting system based on deep learning |
| CN112842253A (en) * | 2021-01-19 | 2021-05-28 | 北京大学第三医院（北京大学第三临床医学院） | Dry eye syndrome detection device and method based on Placido plate optimized by projection |
| CN112914497A (en) * | 2021-01-19 | 2021-06-08 | 北京大学第三医院（北京大学第三临床医学院） | Dry eye mechanical examination device and use method |
| CN113822928A (en) * | 2021-11-22 | 2021-12-21 | 杭州目乐医疗科技股份有限公司 | Corneal topography reconstruction method and device |
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| CN110367926A (en) * | 2019-07-22 | 2019-10-25 | 天津市索维电子技术有限公司 | A kind of xerophthalmia check device and method applied to self-medicine |
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| CN112842253A (en) * | 2021-01-19 | 2021-05-28 | 北京大学第三医院（北京大学第三临床医学院） | Dry eye syndrome detection device and method based on Placido plate optimized by projection |
| CN112914497A (en) * | 2021-01-19 | 2021-06-08 | 北京大学第三医院（北京大学第三临床医学院） | Dry eye mechanical examination device and use method |
| CN112914497B (en) * | 2021-01-19 | 2022-12-09 | 北京大学第三医院（北京大学第三临床医学院） | Xerophthalmia machine inspection device and using method |
| CN112842253B (en) * | 2021-01-19 | 2022-12-09 | 北京大学第三医院（北京大学第三临床医学院） | Dry eye syndrome detection device and method based on Placido plate optimized by projection |
| CN113822928A (en) * | 2021-11-22 | 2021-12-21 | 杭州目乐医疗科技股份有限公司 | Corneal topography reconstruction method and device |
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