CN106492240B - A kind of freeze dryer on-line cleaning and disinfection system and method - Google Patents
A kind of freeze dryer on-line cleaning and disinfection system and method Download PDFInfo
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- CN106492240B CN106492240B CN201610834112.6A CN201610834112A CN106492240B CN 106492240 B CN106492240 B CN 106492240B CN 201610834112 A CN201610834112 A CN 201610834112A CN 106492240 B CN106492240 B CN 106492240B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/093—Cleaning containers, e.g. tanks by the force of jets or sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/14—Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/17—Combination with washing or cleaning means
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Drying Of Solid Materials (AREA)
Abstract
The present invention provides a kind of freeze dryer on-line cleaning and disinfection system, it include: controller, freeze drying box, cooling cylinder, freeze-drying tank inlet and condensation tank inlet are separately connected inlet duct, and the import group of inlet duct is equipped with import total valve, steam port is equipped with steam valve, water inlet is equipped with inlet valve, and air intlet is equipped with air door, and compressed air inlet is equipped with compressed air valve；Freeze drying box is equipped with freeze drying box drainage port, and freeze drying box drainage port is equipped with the first draining drain tap；Cooling cylinder is equipped with cooling cylinder drainage port, and cooling cylinder drainage port is equipped with the second draining drain tap；Freeze drying box drainage port and cooling cylinder drainage port are separately connected drainage exhaust pipeline；System uses the cleaning and sterilizing methods, freeze dryer on-line cleaning and online sterilizing may be implemented, and realize temperature fall time shorter than in the prior art, realizes the convenience of production.Realize energy-saving purpose.
Description
Technical field
The present invention relates to technical fields more particularly to a kind of freeze dryer on-line cleaning that biological products and blood product produce
And disinfection system and method.
Background technique
In the technical field that biological products and blood product produce, for ensure such as protein of the main component in product,
Microorganism is not denaturalized or loses biologos, keeps original character, usually carries out at freeze-drying to most of product
Reason.Every time before freeze-drying, freeze drying box, cooling cylinder and the associated shelf and pipeline of freeze dryer are required to the high temperature injection water with 80 DEG C
It rinses, to ensure the cleaning effect of reactor tank and pipeline.After the completion of on-line cleaning, also need to carry out freeze-drying of the pure steam to freeze dryer
Case, cooling cylinder and associated shelf and pipeline sterilize, to ensure cleaning, the apyrogeneity state of equipment, pipeline.
Now in field of biological pharmacy, the product that such as continuously ferments, the preparation with potency and easy in inactivation product are both needed to half
Finished product completes packing after preparing within the time short to the greatest extent, is lyophilized.And traditional freeze dryer on-line cleaning and online sterilizing
Afterwards, 24 hours are at least needed by the way of Temperature fall, can not achieve the quick application of equipment, influence successive batches of productions
Technique scheduling of production.Freeze dryer on-line cleaning and line sterilizing after, generally the natural type of cooling cool down；Also have and propose that water is cooling
Collet shell design, specifically for being quickly cooled down after line sterilizing for large scale equipment freeze drying box and condenser.The above method exist with
Lower problem: 1) if carrying out natural cooling after line sterilizing, since body of freeze dryer and pipeline have insulating layer, when leading to cooling
Between it is too long, influence the arrangement of production technology；2) existing most of freeze dryers use after line sterilizing, are naturally cooled to certain temperature
Degree is opened compressor and circulating pump, is cooled down using the silicone oil of cooling to shelf.Though this method can be realized to a certain extent
Freeze dryer use before fast cooling, but energy consumption is larger；3) water cooling jacket shell designs not only waste water resource, can't realize
The uniform decrease in temperature of each component of freeze drying box, and then there is the risk of product pollution if there is leakage in collet.
Summary of the invention
In order to overcome the deficiencies in the prior art described above, the object of the present invention is to provide a kind of freeze dryer on-line cleanings
And disinfection system,
First temperature sensing receiving module is used to receive the temperature values of the first temperature sensor senses, and by the temperature value
It is transmitted to central processing unit；
Second temperature sensing receiving module is used to receive the temperature value of second temperature sensor induction, and by the temperature value
It is transmitted to central processing unit；
Second pressure sensing receiving module is used to receive the pressure value of second pressure sensor sensing, and by the pressure value
It is transmitted to central processing unit；
First entrance valve control module is used for the control instruction according to central processing unit, and control first entrance valve is opened
It closes；
Second entrance valve control module is used for the control instruction according to central processing unit, and control second entrance valve is opened
It closes；
Steam valve control module is used for the control instruction according to central processing unit, controls the switch of steam valve；
Inlet valve control module is used for the control instruction according to central processing unit, controls the switch of inlet valve；
Ejected wash water timer is used for the control instruction according to central processing unit, the duration that metering inlet valve is opened；
Air door control module is used for the control instruction according to central processing unit, the switch of control air valve door；
Compressed air valve control module is used for the control instruction according to central processing unit, and control compressed air valve is opened
It closes；
First draining drain tap control module is used for the control instruction according to central processing unit, controls the first drainage exhaust
The switch of valve；
Second draining drain tap control module is used for the control instruction according to central processing unit, controls the second drainage exhaust
The switch of valve；
First vacuum pump control module is used for the control instruction according to central processing unit, controls the switch of the first vacuum pump；
Second vacuum pump control module is used for the control instruction according to central processing unit, controls the switch of the second vacuum pump；
First vacuum timer is used for the control instruction according to central processing unit, records the opening time of the first vacuum pump；
Second vacuum timer is used for the control instruction according to central processing unit, records the opening time of the second vacuum pump；
First circulation control valve control module is used for the control instruction according to central processing unit, controls first circulation control valve
Switch；
Second circulation control valve control module is used for the control instruction according to central processing unit, controls second circulation control valve
Switch；
Central processing unit is used to receive the command information that user inputs by operation panel, and according to command information to control
Device internal module issues control instruction, and system is made to execute the command information of user's input；
Operation panel is equipped with touch screen.
Preferably, first circulation pump group includes: the multiple first circulations pump being set side by side, and each first circulation pump is all connected with
There is circulating pump control valve.
Preferably, second circulation pump group includes: the multiple second circulations pump being set side by side, and each second circulation pump is all connected with
There is circulating pump control valve.
Preferably, the connecting pipe between cooling cylinder and freeze drying box is equipped with interval valve；
Controller further include: interval valve control module；
Interval valve control module is used to control the switch of interval valve.
Preferably, drainage exhaust pipeline is equipped with gas discharge outlet and liquid outlet；
Gas discharge outlet is equipped with gas exhaust valve door；Liquid outlet is equipped with liquid discharge valve door；
Controller further include: gas exhaust valve door control module, liquid discharge valve door control module；
Gas exhaust valve door control module is used to control the switch of gas exhaust valve door；
Liquid discharge valve door control module is used to control the switch of liquid discharge valve door.
A kind of freeze dryer on-line cleaning and sterilizing methods, method include:
It opens the first vacuum pump to vacuumize freeze drying box inside, opens the second vacuum pump and cooling cylinder inside is taken out
Vacuum, vacuumize when it is 1 to 2 minute a length of；
The first vacuum pump and the second vacuum pump are closed, successively unlatching import total valve, air door, first entrance valve,
Second entrance valve, the first draining drain tap, the second draining drain tap, gas exhaust valve door, interval valve make in freeze drying box
Portion and cooling cylinder internal pressure are restored to atmospheric pressure；
Freeze drying box internal pressure and cooling cylinder internal pressure are restored to atmospheric pressure, and air door, gas exhaust valve are closed
Door；Successively open inlet valve, liquid discharge valve door, first circulation pump group, second circulation pump group, within a preset time to freeze-drying
It is cleaned inside case and cooling cylinder, after default scavenging period, closes inlet valve, first entrance valve, second entrance
First circulation pump group, second circulation pump group, the first draining are closed in valve, the emptying inside freeze drying box and cooling cylinder by ejected wash water
Drain tap, the second draining drain tap, liquid discharge valve door；
It opens the first vacuum pump to vacuumize freeze drying box inside, opens the second vacuum pump and cooling cylinder inside is taken out
Vacuum, vacuumize when it is 30 to 40 minutes a length of；
When freeze drying box and cooling cylinder internal pressure are more than or equal to 30kPa, the first draining drain tap, the second draining are opened
Drain tap, gas exhaust valve door, liquid discharge valve door close gas exhaust valve door and liquid row after default efflux time
Valve out；
Steam valve, first entrance valve are opened, second entrance valve is full of steam inside freeze drying box and cooling cylinder,
When temperature inside freeze drying box and cooling cylinder reaches default sterilising temp, start to calculate sterilization time；After reaching sterilization time,
Steam off valve opens gas exhaust valve door after default delay time, liquid discharge valve door, and freeze drying box and cold is discharged
Steam inside solidifying case；
After default delay time, inlet valve, first circulation pump group, second circulation pump group, in preset time are opened
It is interior to being cleaned inside freeze drying box and cooling cylinder, after default scavenging period, close inlet valve, the first draining exhaust valve
Door, the second draining drain tap, first circulation pump group, second circulation pump group open air door, filtrated air are made to enter freeze-drying
Case and cooling cylinder close air door until pressure is atmospheric pressure in freeze drying box and cooling cylinder；
After default delay time, compressed air valve, the first draining drain tap and the second draining exhaust valve are opened
Door, purges system, and when freeze drying box and cooling cylinder internal temperature and pressure, which reach technique, to be required, it is empty successively to close compression
Air valve, gas exhaust valve door, liquid discharge valve door, import total valve, first entrance valve, second entrance valve, first row
Water drain tap, the second draining drain tap.
As can be seen from the above technical solutions, the invention has the following advantages that
System uses the cleaning and sterilizing methods, freeze dryer on-line cleaning and online sterilizing may be implemented, and realize ratio
Shorter temperature fall time in the prior art realizes the convenience of production.Meanwhile on the basis of ensuring cleaning effect, not only
Temperature fall time after shortening cleaning, while energy-saving, the purpose of water conservation may be implemented.
Detailed description of the invention
In order to illustrate more clearly of technical solution of the present invention, attached drawing needed in description will be made below simple
Ground introduction, it should be apparent that, drawings in the following description are only some embodiments of the invention, for ordinary skill
For personnel, without creative efforts, it is also possible to obtain other drawings based on these drawings.
Fig. 1 is the overall structure figure of freeze dryer on-line cleaning and disinfection system；
Fig. 2 is the control schematic diagram of freeze dryer on-line cleaning and disinfection system；
Fig. 3 is freeze dryer on-line cleaning and sterilizing methods flow chart.
Specific embodiment
It in order to make the invention's purpose, features and advantages of the invention more obvious and easy to understand, below will be with specific
Examples and drawings, the technical solution protected to the present invention are clearly and completely described, it is clear that implementation disclosed below
Example is only a part of the embodiment of the present invention, and not all embodiment.Based on the embodiment in this patent, the common skill in this field
Art personnel all other embodiment obtained without making creative work belongs to the model of this patent protection
It encloses.
The present embodiment provides a kind of freeze dryer on-line cleaning and disinfection systems, as shown in Figure 1 and Figure 2, comprising: controller freezes
Dry case 1, the cooling cylinder 2 being connected to freeze drying box 1 by pipeline, freeze drying box 1 are equipped with freeze-drying tank inlet and are located at freeze-drying tank inlet
First entrance valve 3, cooling cylinder 2 be equipped with condensation tank inlet and be located at condensation tank inlet second entrance valve 4, freeze drying box
Entrance and condensation tank inlet are separately connected inlet duct 5, and the import group of inlet duct 5 is equipped with import total valve 41, total with import
The connection of valve 41 is equipped with steam valve 42, connect use with import total valve 41 for providing the steam port 6 of steam, steam port 6
In providing the water inlet 7 of ejected wash water, water inlet 7 is equipped with inlet valve 43, connect with import total valve 41 for providing room temperature
The air intlet 8 of pure air, air intlet 8 are equipped with air door 44, connect with import total valve 41 for providing compression
The compressed air inlet 9 of air, compressed air inlet 9 are equipped with compressed air valve 45；Freeze drying box 1 is equipped with freeze drying box drainage
Port, freeze drying box drainage port are equipped with the first draining drain tap 50；Cooling cylinder 2 is equipped with cooling cylinder drainage port, cold
Solidifying case drainage port is equipped with the second draining drain tap 52；Freeze drying box drainage port and cooling cylinder drainage port difference
Connect drainage exhaust pipeline 56；
Freeze drying box 1 is connected with for the first vacuum pump 46 vacuumized inside freeze drying box 1；Cooling cylinder 2 is connected with
For to the second vacuum pump 48 vacuumized inside cooling cylinder 2；First pressure sensor, first are equipped with inside freeze drying box 1
Temperature sensor；Freeze drying box 1 is equipped with first circulation pipeline, and first circulation pipeline is followed equipped with first circulation pump group 55 and first
Ring control valve 49；Second pressure sensor, second temperature sensor are equipped with inside cooling cylinder 2；Cooling cylinder 2 is equipped with second circulation pipe
Road, second circulation pipeline are equipped with second circulation pump group 57 and second circulation control valve 51；
Controller include: central processing unit 10, operation panel 32, import main valve door control module 11, sterilizing timer 12,
First pressure senses receiving module 13, the first temperature sensing receiving module 14, second temperature and senses receiving module 15, second pressure
Sense receiving module 16, first entrance valve control module 17, second entrance valve control module 18, steam valve control module
19, inlet valve control module 20, ejected wash water timer 21, air door control module 22, compressed air valve control module
23, the first draining drain tap control module 24, second drains drain tap control module 25, the first vacuum pump control module
26, the second vacuum pump control module 27, the first vacuum timer 28, the second vacuum timer 29, the control of first circulation control valve
Module 30, second circulation control valve control module 31.
Import main valve door control module 11 is used for the control instruction according to central processing unit 10, control import total valve 41
Switch；The timer 12 that sterilizes is used for the control instruction according to central processing unit 10, counts to freeze drying box 1 and the sterilizing of cooling cylinder 2
When；First pressure sensing receiving module 13 is used to receive the pressure value of first pressure sensor induction, and the pressure value is passed
Transport to central processing unit 10；First temperature sensing receiving module 14 is used to receive the temperature value of the first temperature sensor senses, and
The temperature value is transmitted to central processing unit 10；Second temperature sensing receiving module 15 is for receiving second temperature sensor sense
The temperature value answered, and the temperature value is transmitted to central processing unit 10；Second pressure senses receiving module 16 for receiving the
The pressure value of two pressure sensors induction, and the pressure value is transmitted to central processing unit 10；First entrance valve controls mould
Block 17 is used for the control instruction according to central processing unit, controls the switch of first entrance valve；Second entrance valve control module
18, for the control instruction according to central processing unit, control the switch of second entrance valve；Steam valve control module 19 is used for
According to the control instruction of central processing unit, the switch of steam valve is controlled；Inlet valve control module 20 is used for according to centre
The control instruction for managing device, controls the switch of inlet valve；Ejected wash water timer 21 is used for the control instruction according to central processing unit,
Measure the duration that inlet valve is opened；Air door control module 22 is used for the control instruction according to central processing unit, and control is empty
The switch of air valve；Compressed air valve control module 23 is used for the control instruction according to central processing unit, controls compressed air
The switch of valve；First draining drain tap control module 24 is used for the control instruction according to central processing unit, controls first row
The switch of water drain tap；Second draining drain tap control module 25 is used for the control instruction according to central processing unit, control
The switch of second draining drain tap；First vacuum pump control module 26 is used for the control instruction according to central processing unit, control
The switch of first vacuum pump；Second vacuum pump control module 27 is used for the control instruction according to central processing unit, and control second is true
The switch of sky pump；First vacuum timer 28 is used for the control instruction according to central processing unit, records the unlatching of the first vacuum pump
Duration；Second vacuum timer 29 is used for the control instruction according to central processing unit, records the opening time of the second vacuum pump；The
One circulation control valve control module 30 is used for the control instruction according to central processing unit, controls the switch of first circulation control valve；
Second circulation control valve control module 31 is used for the control instruction according to central processing unit, and control second circulation control valve is opened
It closes；Central processing unit 10 is used to receive the command information of user's input by operation panel 32, and according to command information to control
Device internal module issues control instruction, and system is made to execute the command information of user's input；Operation panel is equipped with touch screen.
System is equipped with cleaning procedure, purges program, sterilizing program, drying program.It can start according to the technological requirements in this way
Various programs.Specific Starting mode can start automatically according to the technological requirements, can also be by manually starting corresponding program.
Air uses pure air, and water uses pure water.
First circulation pump group 55 includes: the multiple first circulations pump being set side by side, and each first circulation pump, which is respectively connected with, to follow
Ring pump control valve door.Second circulation pump group 57 includes: the multiple second circulations pump being set side by side, and each second circulation pump is all connected with
There is circulating pump control valve.Connecting pipe between cooling cylinder 2 and freeze drying box 1 is equipped with interval valve 47.
Controller further include: interval valve control module；Interval valve control module is used to control the switch of interval valve.Drainage
Feed channel 56 is equipped with gas discharge outlet and liquid outlet；Gas discharge outlet is equipped with gas exhaust valve door 53；Liquid outlet
It is equipped with liquid discharge valve door 54.
Controller further include: gas exhaust valve door control module, liquid discharge valve door control module；Gas exhaust valve gate
Molding block is used to control the switch of gas exhaust valve door；Liquid discharge valve door control module is for controlling opening for liquid discharge valve door
It closes.
The present invention also provides a kind of freeze dryer on-line cleaning and sterilizing methods, as shown in figure 3, method includes:
S1: open the first vacuum pump freeze drying box inside is vacuumized, open the second vacuum pump to cooling cylinder inside into
Row vacuumize, vacuumize when it is 1 to 2 minute a length of；
S2: closing the first vacuum pump and the second vacuum pump, successively opens import total valve, air door, first entrance valve
Door, second entrance valve, the first draining drain tap, the second draining drain tap, gas exhaust valve door, make inside freeze drying box and
Cooling cylinder internal pressure is restored to atmospheric pressure；
S3: freeze drying box internal pressure and cooling cylinder internal pressure are restored to atmospheric pressure, close air door, gas discharge
Valve；Successively open inlet valve, liquid discharge valve door, first circulation pump group, second circulation pump group, within a preset time to jelly
It is cleaned inside dry case and cooling cylinder, after default scavenging period, closes inlet valve, first entrance valve, second enters
Mouth valve, by ejected wash water, the emptying inside freeze drying box and cooling cylinder, closes first circulation pump group, second circulation pump group, first row
Water drain tap, the second draining drain tap, liquid discharge valve door；
S4: open the first vacuum pump freeze drying box inside is vacuumized, open the second vacuum pump to cooling cylinder inside into
Row vacuumize, vacuumize when it is 30 to 40 minutes a length of；
S5: when freeze drying box and cooling cylinder internal pressure are more than or equal to 30kPa, opening the first draining drain tap, second
Drainage exhaust valve, gas exhaust valve door, liquid discharge valve door close gas exhaust valve door and liquid after default efflux time
Body discharge valve；
S6: opening steam valve, first entrance valve, and second entrance valve makes steam full of in freeze drying box and cooling cylinder
Portion when the temperature inside freeze drying box and cooling cylinder reaches default sterilising temp, starts to calculate sterilization time；Reach sterilization time
Afterwards, steam off valve opens gas exhaust valve door after default delay time, liquid discharge valve door, discharge freeze drying box and
Steam inside cooling cylinder；
S7: after default delay time, inlet valve, first circulation pump group, second circulation pump group, when default are opened
In to being cleaned inside freeze drying box and cooling cylinder, after default scavenging period, close inlet valve, the first drainage exhaust
Valve, the second draining drain tap, first circulation pump group, second circulation pump group open air door, filtrated air are made to enter jelly
Dry case and cooling cylinder close air door until pressure is atmospheric pressure in freeze drying box and cooling cylinder；
S8: after default delay time, compressed air valve, the first draining drain tap and the second drainage exhaust are opened
Valve purges system, when freeze drying box and cooling cylinder internal temperature and pressure, which reach technique, to be required, successively closes compression
Air door, gas exhaust valve door, liquid discharge valve door, import total valve, first entrance valve, second entrance valve, first
Drainage exhaust valve, the second draining drain tap.
Illustrated to absolutely prove below method provided by the invention with specific embodiment.
Confirmation before freeze dryer cleaning: confirm that freeze dryer to be cleaned is in off state and does not carry out automatically controlling.Freeze drying box
With in cooling cylinder without glass molding bottle, the sundries such as rubber plug.
Ensuring that air intlet supplies air pressure >=0.5MPa, the purging pressure of compressed air air supply source is 0.1 ~
0.3MPa.Freeze drying box and cooling cylinder pressure sensor show normal atmosphere (An) value.
It opens the first vacuum pump to vacuumize freeze drying box inside, opens the second vacuum pump and cooling cylinder inside is taken out
Vacuum, vacuumize when it is 1 to 2 minute a length of；
The first vacuum pump and the second vacuum pump are closed, successively unlatching import total valve, air door, first entrance valve,
Second entrance valve, the first draining drain tap, the second draining drain tap, gas exhaust valve door, interval valve make in freeze drying box
Portion and cooling cylinder internal pressure are restored to atmospheric pressure；
Freeze drying box internal pressure and cooling cylinder internal pressure are restored to atmospheric pressure, and air door, gas exhaust valve are closed
Door；Successively open inlet valve, liquid discharge valve door, first circulation pump group, second circulation pump group, in freeze drying box and cooling cylinder
Portion is cleaned, cleaning 15 ~ after twenty minutes, close inlet valve, first entrance valve, second entrance valve, by ejected wash water from
First circulation pump group, second circulation pump group, the first draining drain tap, second row are closed in emptying inside freeze drying box and cooling cylinder
Water drain tap, liquid discharge valve door；
If cleaning terminates to sterilize in place in 2 hours without freeze dryer, water ring pump inlet valve, water ring pump, water ring pump are opened
Isolating valve and freeze drying box and cooling cylinder dump valve after carrying out vacuum drying 20 ~ 30 minutes, close freeze drying box and cooling cylinder discharge
Valve, water ring pump isolation valve, water ring pump, water ring pump inlet valve, freeze dryer incumbent firms terminate.
It opens the first vacuum pump to vacuumize freeze drying box inside, opens the second vacuum pump and cooling cylinder inside is taken out
Vacuum, vacuumize when it is 30 to 40 minutes a length of；When freeze drying box and cooling cylinder internal pressure are more than or equal to 30kPa, the is opened
One drainage exhaust valve, the second draining drain tap, gas exhaust valve door, liquid discharge valve door, after default efflux time
Close gas exhaust valve door and liquid discharge valve door；
System sterilizes online: sterilising cycle, and within cleaning validity period, each freeze-dried products go out in 48 hours before entering cabinet
Bacterium program.
Steam valve, first entrance valve are opened, second entrance valve is full of steam inside freeze drying box and cooling cylinder,
Steam enters pressure in cabinet rear cabinet and gradually rises, and when pressure is greater than or equal to 30KPa in case, starts to calculate sterilization time；
After reaching sterilization time, steam off valve, after default delay time, opening gas exhaust valve door, liquid discharge valve door,
The steam inside freeze drying box and cooling cylinder is discharged；
Steam enters pressure in cabinet rear cabinet and gradually rises, when in case pressure be greater than or equal to 30Kpa, open discharge outlet,
Exhaust outlet valve；Start accumulative timing when sterilising temp is greater than or equal to 121 DEG C of set temperature.It is wanted when sterilization time reaches setting
Sterilizing terminates when asking 30 minutes.Steam off valve；Scupper valve, exhaust outlet valve are opened after 2 seconds.
Sterilizing-drying: after 20 ~ 30 minutes delay times, open compressed air valve, first draining drain tap and
Second draining drain tap, purges system, when freeze drying box and cooling cylinder internal temperature and pressure, which reach technique, to be required,
Compressed air valve is successively closed, gas exhaust valve door, liquid discharge valve door, import total valve, first entrance valve, second enters
Mouth valve, the first draining drain tap, the second draining drain tap.
Each embodiment in this specification is described in a progressive manner, the highlights of each of the examples are with other
The difference of embodiment, the same or similar parts in each embodiment refer to mutually.
Description and claims of this specification and term " first ", " second ", " third " " in above-mentioned attached drawing
The (if present)s such as four " are to be used to distinguish similar objects, without being used to describe a particular order or precedence order.It should manage
The data that solution uses in this way are interchangeable under appropriate circumstances, so as to the embodiment of the present invention described herein can in addition to
Here the sequence other than those of diagram or description is implemented.In addition, term " includes " and " having " and their any deformation,
It is intended to cover and non-exclusive includes.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest scope of cause.
Claims (6)
1. a kind of freeze dryer on-line cleaning and disinfection system characterized by comprising controller, freeze drying box pass through with freeze drying box
The cooling cylinder of pipeline connection, freeze drying box are equipped with freeze-drying tank inlet and are located at the first entrance valve of freeze-drying tank inlet, cooling cylinder
Equipped with condensing tank inlet and being located at the second entrance valve of condensation tank inlet, freeze-drying tank inlet and condensation tank inlet are separately connected
The import group of inlet duct, inlet duct is equipped with import total valve, is connect with import total valve for providing the steam port of steam,
Steam port is equipped with steam valve, is connect with import total valve for providing the water inlet of ejected wash water, water inlet is equipped with water inlet
Valve is connect for providing the air intlet of room temperature pure air with import total valve, and air intlet is equipped with air door, with
The connection of import total valve is equipped with compressed air valve for providing the compressed air inlet of compressed air, compressed air inlet；
Freeze drying box is equipped with freeze drying box drainage port, and freeze drying box drainage port is equipped with the first draining drain tap；Cooling cylinder is equipped with
Cooling cylinder drainage port, cooling cylinder drainage port are equipped with the second draining drain tap；Freeze drying box drainage port and cold
Solidifying case drainage port is separately connected drainage exhaust pipeline；
Freeze drying box is connected with the first vacuum pump for being vacuumized to freeze drying box inside；Cooling cylinder is connected with for condensation
The second vacuum pump vacuumized inside case；
First pressure sensor, the first temperature sensor are equipped with inside freeze drying box；Freeze drying box is equipped with first circulation pipeline, and first follows
Endless tube road is equipped with first circulation pump group and first circulation control valve；
Second pressure sensor, second temperature sensor are equipped with inside cooling cylinder；Cooling cylinder is equipped with second circulation pipeline, and second follows
Endless tube road is equipped with second circulation pump group and second circulation control valve；
Controller includes: central processing unit, operation panel, import main valve door control module, sterilizing timer, first pressure sensing
Receiving module, the first temperature sensing receiving module, second temperature sensing receiving module, second pressure sense receiving module, first
Inlet valve control module, second entrance valve control module, steam valve control module, inlet valve control module, cleaning
Water timer, air door control module, compressed air valve control module, the first draining drain tap control module, second
Drainage exhaust valve control module, the first vacuum pump control module, the second vacuum pump control module, the first vacuum timer,
Two vacuum timers, first circulation control valve control module, second circulation control valve control module；
Import main valve door control module is used for the control instruction according to central processing unit, controls the switch of import total valve；
The timer that sterilizes is used for the control instruction according to central processing unit, carries out timing to freeze drying box and condensation box sterilization；
First pressure sensing receiving module is used to receive the pressure value of first pressure sensor induction, and the pressure value is transmitted
To central processing unit；
First temperature sensing receiving module is used to receive the temperature value of the first temperature sensor senses, and the temperature value is transmitted
To central processing unit；
Second temperature sensing receiving module is used to receive the temperature value of second temperature sensor induction, and the temperature value is transmitted
To central processing unit；
Second pressure sensing receiving module is used to receive the pressure value of second pressure sensor sensing, and the pressure value is transmitted
To central processing unit；
First entrance valve control module is used for the control instruction according to central processing unit, controls the switch of first entrance valve；
Second entrance valve control module is used for the control instruction according to central processing unit, controls the switch of second entrance valve；
Steam valve control module is used for the control instruction according to central processing unit, controls the switch of steam valve；
Inlet valve control module is used for the control instruction according to central processing unit, controls the switch of inlet valve；
Ejected wash water timer is used for the control instruction according to central processing unit, the duration that metering inlet valve is opened；
Air door control module is used for the control instruction according to central processing unit, the switch of control air valve door；
Compressed air valve control module is used for the control instruction according to central processing unit, controls the switch of compressed air valve；
First draining drain tap control module is used for the control instruction according to central processing unit, control the first draining drain tap
Switch；
Second draining drain tap control module is used for the control instruction according to central processing unit, control the second draining drain tap
Switch；
First vacuum pump control module is used for the control instruction according to central processing unit, controls the switch of the first vacuum pump；
Second vacuum pump control module is used for the control instruction according to central processing unit, controls the switch of the second vacuum pump；
First vacuum timer is used for the control instruction according to central processing unit, records the opening time of the first vacuum pump；
Second vacuum timer is used for the control instruction according to central processing unit, records the opening time of the second vacuum pump；
First circulation control valve control module is used for the control instruction according to central processing unit, and control first circulation control valve is opened
It closes；
Second circulation control valve control module is used for the control instruction according to central processing unit, and control second circulation control valve is opened
It closes；
Central processing unit is used to receive the command information of user's input by operation panel, and according to command information into controller
Portion's module issues control instruction, and system is made to execute the command information of user's input；
Operation panel is equipped with touch screen.
2. freeze dryer on-line cleaning according to claim 1 and disinfection system, which is characterized in that
First circulation pump group includes: the multiple first circulations pump being set side by side, and each first circulation pump is respectively connected with circulating pump control
Valve processed.
3. freeze dryer on-line cleaning according to claim 1 and disinfection system, which is characterized in that
Second circulation pump group includes: the multiple second circulations pump being set side by side, and each second circulation pump is respectively connected with circulating pump control
Valve processed.
4. freeze dryer on-line cleaning according to claim 1 and disinfection system, which is characterized in that
Connecting pipe between cooling cylinder and freeze drying box is equipped with interval valve；
Controller further include: interval valve control module；
Interval valve control module is used to control the switch of interval valve.
5. freeze dryer on-line cleaning according to claim 1 and disinfection system, which is characterized in that
Drainage exhaust pipeline is equipped with gas discharge outlet and liquid outlet；
Gas discharge outlet is equipped with gas exhaust valve door；Liquid outlet is equipped with liquid discharge valve door；
Controller further include: gas exhaust valve door control module, liquid discharge valve door control module；
Gas exhaust valve door control module is used to control the switch of gas exhaust valve door；
Liquid discharge valve door control module is used to control the switch of liquid discharge valve door.
6. a kind of freeze dryer on-line cleaning and sterilizing methods, which is characterized in that method includes:
It opens the first vacuum pump to vacuumize freeze drying box inside, opens the second vacuum pump and cooling cylinder inside take out very
Sky, vacuumize when it is 1 to 2 minute a length of；
The first vacuum pump and the second vacuum pump are closed, successively unlatching import total valve, air door, first entrance valve, second
Inlet valve, the first draining drain tap, the second draining drain tap, gas exhaust valve door, interval valve make inside freeze drying box and
Cooling cylinder internal pressure is restored to atmospheric pressure；
Freeze drying box internal pressure and cooling cylinder internal pressure are restored to atmospheric pressure, and air door, gas exhaust valve door are closed；According to
Secondary unlatching inlet valve, liquid discharge valve door, first circulation pump group, second circulation pump group, within a preset time to freeze drying box and
It is cleaned inside cooling cylinder, after default scavenging period, closing inlet valve, first entrance valve, second entrance valve,
First circulation pump group, second circulation pump group, the first draining exhaust valve are closed in the emptying inside freeze drying box and cooling cylinder by ejected wash water
Door, the second draining drain tap, liquid discharge valve door；
It opens the first vacuum pump to vacuumize freeze drying box inside, opens the second vacuum pump and cooling cylinder inside take out very
Sky, vacuumize when it is 30 to 40 minutes a length of；
When freeze drying box and cooling cylinder internal pressure are more than or equal to 30kPa, the first draining drain tap, the second drainage exhaust are opened
Valve, gas exhaust valve door, liquid discharge valve door close gas exhaust valve door and liquid discharge valve after default efflux time
Door；
Steam valve, first entrance valve are opened, second entrance valve is full of steam inside freeze drying box and cooling cylinder, works as jelly
When temperature inside dry case and cooling cylinder reaches default sterilising temp, start to calculate sterilization time；After reaching sterilization time, close
Steam valve opens gas exhaust valve door after default delay time, and freeze drying box and cooling cylinder is discharged in liquid discharge valve door
Internal steam；
After default delay time, inlet valve is opened, first circulation pump group, second circulation pump group is right within a preset time
It is cleaned inside freeze drying box and cooling cylinder, after default scavenging period, closes inlet valve, first drains drain tap,
Second draining drain tap, first circulation pump group, second circulation pump group open air door, filtrated air are made to enter freeze drying box
And cooling cylinder closes air door until pressure is atmospheric pressure in freeze drying box and cooling cylinder；
After default delay time, compressed air valve, the first draining drain tap and the second draining drain tap are opened, it is right
System is purged, and when freeze drying box and cooling cylinder internal temperature and pressure, which reach technique, to be required, successively closes compressed air valve
Door, gas exhaust valve door, liquid discharge valve door, import total valve, first entrance valve, second entrance valve, the first drainage
Air valve, the second draining drain tap.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610834112.6A CN106492240B (en) | 2016-09-20 | 2016-09-20 | A kind of freeze dryer on-line cleaning and disinfection system and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610834112.6A CN106492240B (en) | 2016-09-20 | 2016-09-20 | A kind of freeze dryer on-line cleaning and disinfection system and method |
Publications (2)
| Publication Number | Publication Date |
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| CN106492240A CN106492240A (en) | 2017-03-15 |
| CN106492240B true CN106492240B (en) | 2019-04-16 |
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| Application Number | Title | Priority Date | Filing Date |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112335724A (en) * | 2020-11-12 | 2021-02-09 | 青岛博瑞设备制造有限公司 | Freeze-drying and moisture regaining equipment |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530373A (en) * | 2008-03-14 | 2009-09-16 | 蔡强 | Freeze drying unit for preparing lipidosome medicament and common medicament |
| CN201569255U (en) * | 2009-07-30 | 2010-09-01 | 上海东富龙科技股份有限公司 | Fully-automatic intelligent vacuum freezing drier |
-
2016
- 2016-09-20 CN CN201610834112.6A patent/CN106492240B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530373A (en) * | 2008-03-14 | 2009-09-16 | 蔡强 | Freeze drying unit for preparing lipidosome medicament and common medicament |
| CN201569255U (en) * | 2009-07-30 | 2010-09-01 | 上海东富龙科技股份有限公司 | Fully-automatic intelligent vacuum freezing drier |
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Address after: 271000 5666 Longquan Road, hi tech Zone, Tai'an, Shandong Patentee after: SHANDONG TAIBANG BIOLOGICAL PRODUCTS Co.,Ltd. Address before: 271000 No. 14 East Tiger Hill Road, Shandong, Tai'an Patentee before: SHANDONG TAIBANG BIOLOGICAL PRODUCTS Co.,Ltd. |