CN106492196A - One broad sow immunostimulant - Google Patents
One broad sow immunostimulant Download PDFInfo
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- CN106492196A CN106492196A CN201611024298.5A CN201611024298A CN106492196A CN 106492196 A CN106492196 A CN 106492196A CN 201611024298 A CN201611024298 A CN 201611024298A CN 106492196 A CN106492196 A CN 106492196A
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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Abstract
The present invention relates to veterinary biological product technical field, and in particular to a broad sow immunostimulant；It is made up of following raw material by weight：IFN-γ 4～6, cytosine guanine oligodeoxynucleotide 10～15, EGF epithelical cell growth factors 6～9, lysine 2.5～3, L-Valine 1～2, micro-powder of Chinese herbs 7～9, microcapsule coating 31～44；Reinforcing agent of the present invention effectively strengthens the immune system of sow, improve sow immunity and resistance, reduce the sickness rate of sow, improve the litter size of sow, improve lactation amount and the milking qualities of sow, sow is acted on by IFN-γ, cytosine guanine oligodeoxynucleotide and EGF epithelical cell growth factors, EGF can promote IFN-γ and cytosine guanine oligodeoxynucleotide in the absorption of little intestinal segment, effectively improve the immune effect of sow.
Description
Technical field
The present invention relates to veterinary biological product technical field, and in particular to a broad sow immunostimulant.
Background technology
Sows farrowing can consume big energy, make enterogastric peristalsis slow, and digestive function declines, and anorexia or feeding are reduced, and are made
Into constipation, so it is unfavorable for physical recovery in puerperal and later suckling of giving milk；Next sow puerperal fever, lassitude, equally
Decline premunition, easy infection obstetric conditions；Although in this case, having done Full-access immunization to sow group, virus is also
To purify, although swinery does not show obvious disease symptom, but its body be unsound, pig body with disease
Need to consume itself a large amount of physical ability while malicious game, the normal physiological function of pig can be subject to extreme influence, particularly to reproduction
Function affects maximum, body to be not enough to support its heat ovulation, if pregnancy and nursing sow, can also cause miscarriage, stillborn fetuses
Or milk is not enough, in milk, antibody is reduced and causes nursing sow weak and sickly, and death rate rises；In addition mycotoxin and other industry
Pollution causes soil, water source even air Pesticides, heavy metal accumulation, so as to pollute feedstuff, causes sow immunosuppressant,
Swinery is chronically at sub-health state, and being particularly these poisonous and harmful substances can cause sow Reproductive Performance to decline or even lose
Function, ultimately results in sow reproductive performance low；Add antibiotic in feedstuff for a long time or just do not treat the usage of disease, consumption
Really, abuse of antibiotics is caused, makes sow Liver and kidney be poisoned, reduce Abwehrkraft des Koepers, swinery is in sub-health state, the direct damage having
Evil reproductive system, causes sow reproductive performance to decline.
In the development of pig aquaculture, sow is basic, and the health condition of sow itself directly affects foetus health, shadow
Ring its Milk Production；And the measure for effectively improving sow immunity is the key for ensureing sow health, at present, due to many-sided reason
Cause sow autoimmune to decline, cause sow feed intake to decline, litter size declines, the low situation of sow survival rate, stream occurs
Produce, stillborn fetuses or milk are not enough, therefore the low situation of Oestrus rate, improves the immunity and disease resistance of sow, to whole pig aquaculture
For significant.
Content of the invention
The present invention is solution above-mentioned technical problem, there is provided a broad sow immunostimulant.
Realize particular by technical scheme below：
One broad sow immunostimulant, is made up of following raw material by weight：Gamma interferon 4～6, cytosine-
Guanine oligodeoxynucleotide 10～15, EGF epithelical cell growth factors 6～9, lysine 2.5～3, L-Valine 1～2, Chinese medicine
Micropowder 7～9, microcapsule coating 31～44；
Micro-powder of Chinese herbs, is made up of following raw material by weight：Semen Vaccariae 10～15, Pericarpium Citri Reticulatae Viride 6～9, Medulla Tetrapanacis 8～12,
Herba Leonuri 3～5, Radix Achyranthis Bidentatae 4～6, Rhizoma Cyperi 10～13.
Preferably, it is made up of following raw material by weight：Gamma interferon 5, cytosine-guanine widow's deoxynucleoside
Acid 13, EGF epithelical cell growth factors 8, lysine 2.8, L-Valine 1.5, micro-powder of Chinese herbs 8, microcapsule coating 35.
Further, described micro-powder of Chinese herbs, be Chinese medicine is weighed in proportion after, dry to water content be 10～13%, powder
Broken, cross 80～100 mesh sieves, by iron pan be heated to pot temperature for 80～90 DEG C when, by crushing after Chinese medicine powder be put in pot, stir-fry 10
～15min, pulls out, is down to room temperature, you can.
Further, described microcapsule coating, be by cellulose acetate, alginic acid, modified gelatin and water by 1: 0.5～
0.8: 1～1.5: 3～4 mass ratio mixing.
Further, described modified gelatin, is by physiology that carboxymethyl chitosan, gelatin and concentration are 0.11～0.15%
Saline is mixed by 0.2～0.35: 0.9～1.3: 3.5～4 mass ratio, 60～70 DEG C of waters bath with thermostatic control heating, and stirring 15～
20min, concentration are dried, and cross 200～300 mesh sieves, you can.
Further, the sow is comprised the following steps with immunostimulant preparation method：
(1) amino acid treatment：Lysine and L-Valine are weighed in proportion, 1.5～2 times of gross mass after addition mixing
Water, heated and stirred are risen to after 60～70 DEG C to temperature, continue stirring, and it is 2/3 to be concentrated into volume at 60～70 DEG C, is cooled to temperature
After spending for 25～30 DEG C, the ethanol of 5 times of volume after addition concentration, 15～17h of extracting at constant temperature, after ethanol is reclaimed in vacuum distillation,
Take residual solution；
(2) dispensing：By the residual solution of step (1), gamma interferon, cytosine-guanine oligodeoxynucleotide, EGF epidermises
Cell growth factor, micro-powder of Chinese herbs are mixed in proportion, and obtain compound；
(3) microcapsule：The normal saline that carboxymethyl chitosan, gelatin and concentration are 0.11～0.15% is mixed in proportion
Afterwards, after being heated with stirring to 80～90 DEG C, constant temperature stirs 15～20min, is coated in compound, with the frequency of 350～400 times/min
Rate vibrates 15～20min, and microcapsule is obtained by being spray-dried.
Further, the sow immunostimulant, takes in the morning and evening, each takes, by immunostimulant and mother
Pig feed is mixed by 0.3～0.4%: 1 mass ratio.
It is further described to raw materials used below：
EGF epithelical cell growth factors：After EGF and its receptor binding, casein kinase is activated, so as to play its biological work(
Can, such as promote cell growth, cell migration, cell propagation, wound healing, bone healing and nutrient substance transhipment etc..With sodium
The transhipment of the nutrient substance such as ion (Na+), magnesium ion (Mg2+), Phos, glucose, glutamine is relevant, to promoting animal
Growth, raising breeding performonce fo animals play an important role；EGF can promote epithelial cell, fibroblastic increment；Strengthen epidermis thin
The vigor of born of the same parents, can gastric acid secretion inhibiting and the growth and differentiation for stimulating intestinal epithelial cell.
One guanine oligodeoxynucleotide of cytosine：Body can be induced panimmunity effect is produced (as activated immune is thin
Born of the same parents), promote which to secrete cytokine profiles, improve the special and nonspecific immune reaction ability of body, functional study finds,
CpGODN can the immunocyte such as activating B cell, NK cells, Monocytes/Macrophages, dendritic cell, T cell, induction produces IL-
12nd, the cytokine profiles such as TNF-d, INF- γ, promote the table of mhc class ii molecule and costimulating factor CD40, CD80, CD86
Reach.Importantly, it is capable of the processing of enhancement antigen offer, induction immunne response is changed to Th1 types, is produced stronger special
Sexual cell immunity and humoral immunization.
Gamma interferon：It is a kind of cytokine with antiviral, antitumor and immunoregulation effect, mainly by activating
T cell and NK cells produce, gamma interferon has powerful adjustment effect to body immune system, is physical exertion immunity
Function, the indispensable composition of the internal pathogen of removing.
Semen Vaccariae：There is promoting blood circulation to restore menstrual flow, stimulating milk secretion to subside a swelling, effect of inducing diuresis for treating stranguria syndrome.For amenorrhea, dysmenorrhea, agalactia,
Acute mastitis swells and ache, the puckery pain of stranguria.
Pericarpium Citri Reticulatae Viride：There are soothing the liver dispelling the stagnated QI, the stagnant effect of removing food stagnancyization；Can be used for distending pain in the chest and hypochondrium, hernia pain, nodules of the breast, acute mastitis, food stagnation
The stagnation of QI, abdominal distention.
Medulla Tetrapanacis：Attach to the lung and stomach meridians, snobbish clearly water；Lactogenesis, for the puckery pain of stranguria；Dysuria；Edema；Jaundice；Damp-warm diseases；
Oliguria with reddish urine；Puerperal, breast was few；Amenorrhea；Leukorrhagia.
Herba Leonuri：Acrid in the mouth is bitter, cool, invigorates blood circulation, silt of dispelling, regulating menstruation, disappear water, treats menoxenia, and vaginal bleeding during pregnancy is had difficult labour, and afterbirth is not
Under, puerperal blood faintss, abdominal pain due to blood stasis, metrorrhagia and metrostaxises, rush down blood, carbuncle swells sore at hematuria, and Herba Leonuri has inducing diuresis to remove edema, shrink uterus makees
Effect.
Radix Achyranthis Bidentatae：Promoting blood circulation to restore menstrual flow；Control puerperal abdonimal pain, menoxenia, amenorrhea
Rhizoma Cyperi：Dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving；For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, mammary swelling
Bitterly, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass are vexed, distension pain, menoxenia, closed dysmenorrhea.
Sow puerperal hypogalactia can effectively be treated by above-mentioned Chinese medicine, puerperal mastalgia, mastitiss, can not undress any more puerperal, puerperal paralysis
The gynaecopathia such as paralysis and sow lochiopyra.
Lysine：Promote brain development, be the constituent of liver and gallbladder, lipid metabolism can be promoted, adjust pineal gland, breast
Gland, corpus luteum and ovary, prevent cell degradation.
L-Valine：Act on corpus luteum, mammary gland and ovary.
In sum, the beneficial effects of the present invention is：Effectively the immune system of reinforcing sow, improves sow immunity
And resistance, reduce sow sickness rate, improve sow litter size, improve sow lactation amount and milking qualities, by γ-
Interferon, cytosine-guanine oligodeoxynucleotide and EGF epithelical cell growth factors act on sow, and EGF can promote
Gamma interferon and cytosine-guanine oligodeoxynucleotide effectively improve the immune effect of sow in the absorption of little intestinal segment.
Wherein, by the addition of micro-powder of Chinese herbs, can effectively treat sow puerperal hypogalactia, puerperal mastalgia, mastitiss, puerperal
Can do not undress any more, the gynaecopathia such as postpartum paralysis and sow lochiopyra solves the puerperal syndrome of sow, effectively ensures that sow is good for
Health, is that nurture piglet provides safeguard.
Specific embodiment
Below the specific embodiment of the present invention is described in further detail, but the invention is not limited in these realities
Mode is applied, any improvement or replacement on the present embodiment essence spirit still falls within the claims in the present invention required for protection
Scope.
Embodiment 1
One broad sow immunostimulant, is made up of following raw material by weight：Gamma interferon 4g, cytosine-bird
Purine oligodeoxynucleotide 10g, EGF epithelical cell growth factor 6g, lysine 2.5g, L-Valine 1g, micro-powder of Chinese herbs 7g, micro- glue
Capsule coating 31g；
Micro-powder of Chinese herbs, is made up of following raw material by weight：Semen Vaccariae 10g, Pericarpium Citri Reticulatae Viride 6g, Medulla Tetrapanacis 8g, Herba Leonuri 3g,
Radix Achyranthis Bidentatae 4g, Rhizoma Cyperi 10g.
Described micro-powder of Chinese herbs, be Chinese medicine is weighed in proportion after, dry to water content be 10%, crush, cross 80 mesh sieves,
By iron pan be heated to pot temperature for 80～90 DEG C when, by crushing after Chinese medicine powder be put in pot, stir-fry 10min, pulls out, is down to often
Temperature, you can.
Described microcapsule coating, be by cellulose acetate, alginic acid, modified gelatin and water by 1: 0.5: 1: 3 quality
Than mixing.
Described modified gelatin, is by 0.2: 0.9 by normal saline that carboxymethyl chitosan, gelatin and concentration are 0.11%
: 3.5 mass ratio mixing, 60 DEG C of water bath with thermostatic control heating, 15min is stirred, concentration is dried, and crosses 200 mesh sieves, you can.
The sow is comprised the following steps with immunostimulant preparation method：
(1) amino acid treatment：Lysine and L-Valine are weighed in proportion, 1.5 times of gross mass after mixing of water is added,
Heated and stirred, rises to after 60 DEG C to temperature, continues stirring, is concentrated into volume for 2/3 at 60 DEG C, is cooled to temperature for after 25 DEG C,
5 times of volume after concentrating of ethanol, extracting at constant temperature 15h is added after ethanol is reclaimed in vacuum distillation, to take residual solution；
(2) dispensing：By the residual solution of step (1), gamma interferon, cytosine-guanine oligodeoxynucleotide, EGF epidermises
Cell growth factor, micro-powder of Chinese herbs are mixed in proportion, and obtain compound；
(3) microcapsule：After the normal saline that carboxymethyl chitosan, gelatin and concentration are 0.11% is mixed in proportion, stir
Mix after being heated to 80 DEG C, constant temperature stirs 15min, is coated in compound, with the frequency vibration 15min of 350 times/min, by spray
Mist dries and microcapsule is obtained.
The sow immunostimulant, takes in the morning and evening, each takes, immunostimulant is pressed with sow feed
0.003: 1 mass ratio mixing.
Embodiment 2
One broad sow immunostimulant, is made up of following raw material by weight：Gamma interferon 6g, cytosine-bird
Purine oligodeoxynucleotide 15g, EGF epithelical cell growth factor 9g, lysine 3g, L-Valine 2g, micro-powder of Chinese herbs 9g, microcapsule
Coating 44g；
Micro-powder of Chinese herbs, is made up of following raw material by weight：Semen Vaccariae 15g, Pericarpium Citri Reticulatae Viride 9g, Medulla Tetrapanacis 12g, Herba Leonuri
5g, Radix Achyranthis Bidentatae 6g, Rhizoma Cyperi 13g.
Described micro-powder of Chinese herbs, be Chinese medicine is weighed in proportion after, dry to water content be 13%, crush, cross 100 mesh
Sieve, by iron pan be heated to pot temperature for 90 DEG C when, by crushing after Chinese medicine powder be put in pot, stir-fry 15min, pulls out, is down to room temperature,
?.
Described microcapsule coating, be by cellulose acetate, alginic acid, modified gelatin and water by 1: 0.8: 1.5: 4 matter
Amount is than mixing.
Described modified gelatin, is by 0.0.35 by normal saline that carboxymethyl chitosan, gelatin and concentration are 0.15%:
20min is stirred in 1.3: 4 mass ratio mixing, 70 DEG C of water bath with thermostatic control heating, and concentration is dried, and crosses 300 mesh sieves, you can.
The sow is comprised the following steps with immunostimulant preparation method：
(1) amino acid treatment：Lysine and L-Valine are weighed in proportion, 2 times of gross mass after mixing of water is added, plus
Thermal agitation, rises to after 70 DEG C to temperature, continues stirring, is concentrated into volume for 2/3 at 70 DEG C, is cooled to temperature for after 30 DEG C, plus
Enter 5 times of volume after concentrating of ethanol, extracting at constant temperature 17h, after ethanol is reclaimed in vacuum distillation, takes residual solution；
(2) dispensing：By the residual solution of step (1), gamma interferon, cytosine-guanine oligodeoxynucleotide, EGF epidermises
Cell growth factor, micro-powder of Chinese herbs are mixed in proportion, and obtain compound；
(3) microcapsule：After the normal saline that carboxymethyl chitosan, gelatin and concentration are 0.15% is mixed in proportion, stir
Mix after being heated to 90 DEG C, constant temperature stirs 20min, is coated in compound, with the frequency vibration 20min of 400 times/min, by spray
Mist dries and microcapsule is obtained.
The sow immunostimulant, takes in the morning and evening, each takes, immunostimulant is pressed with sow feed
0.004: 1 mass ratio mixing.
Embodiment 3
One broad sow immunostimulant, is made up of following raw material by weight：Gamma interferon 5g, cytosine-bird
Purine oligodeoxynucleotide 13g, EGF epithelical cell growth factor 8g, lysine 2.8g, L-Valine 1.5g, micro-powder of Chinese herbs 8g, micro-
Capsule coating 35g；
Micro-powder of Chinese herbs, is made up of following raw material by weight：Semen Vaccariae 13g, Pericarpium Citri Reticulatae Viride 8g, Medulla Tetrapanacis 10g, Herba Leonuri
4g, Radix Achyranthis Bidentatae 5g, Rhizoma Cyperi 11g.
Described micro-powder of Chinese herbs, be Chinese medicine is weighed in proportion after, dry to water content be 11%, crush, cross 90 mesh sieves,
By iron pan be heated to pot temperature for 85 DEG C when, by crushing after Chinese medicine powder be put in pot, stir-fry 13min, pulls out, is down to room temperature, i.e.,
Can.
Described microcapsule coating, is by 1: 0.7: 1.3: 3.5 by cellulose acetate, alginic acid, modified gelatin and water
Mass ratio mixes.
Described modified gelatin, is by 0.3: 1.1 by normal saline that carboxymethyl chitosan, gelatin and concentration are 0.13%
: 3.8 mass ratio mixing, 65 DEG C of water bath with thermostatic control heating, 18min is stirred, concentration is dried, and crosses 250 mesh sieves, you can.
The sow is comprised the following steps with immunostimulant preparation method：
(1) amino acid treatment：Lysine and L-Valine are weighed in proportion, 1.8 times of gross mass after mixing of water is added,
Heated and stirred, rises to after 65 DEG C to temperature, continues stirring, is concentrated into volume for 2/3 at 65 DEG C, is cooled to temperature for after 28 DEG C,
5 times of volume after concentrating of ethanol, extracting at constant temperature 16h is added after ethanol is reclaimed in vacuum distillation, to take residual solution；
(2) dispensing：By the residual solution of step (1), gamma interferon, cytosine-guanine oligodeoxynucleotide, EGF epidermises
Cell growth factor, micro-powder of Chinese herbs are mixed in proportion, and obtain compound；
(3) microcapsule：After the normal saline that carboxymethyl chitosan, gelatin and concentration are 0.13% is mixed in proportion, stir
Mix after being heated to 85 DEG C, constant temperature stirs 18min, is coated in compound, with the frequency vibration 18min of 380 times/min, by spray
Mist dries and microcapsule is obtained.
The sow immunostimulant, takes in the morning and evening, each takes, immunostimulant is pressed with sow feed
0.35%: 1 mass ratio mixing.
Embodiment 4
One broad sow immunostimulant, is made up of following raw material by weight：Gamma interferon 6g, cytosine-bird
Purine oligodeoxynucleotide 10g, EGF epithelical cell growth factor 9g, lysine 3g, L-Valine 1g, micro-powder of Chinese herbs 7g, microcapsule
Coating 44g；
Micro-powder of Chinese herbs, is made up of following raw material by weight：Semen Vaccariae 15g, Pericarpium Citri Reticulatae Viride 9g, Medulla Tetrapanacis 8g, Herba Leonuri 3g,
Radix Achyranthis Bidentatae 4g, Rhizoma Cyperi 13g.
Described micro-powder of Chinese herbs, be Chinese medicine is weighed in proportion after, dry to water content be 10～13%, crush, cross 80
～100 mesh sieves, by iron pan be heated to pot temperature for 80～90 DEG C when, by crushing after Chinese medicine powder be put in pot, stir-fry 10～
15min, pulls out, is down to room temperature, you can.
Described microcapsule coating, be by cellulose acetate, alginic acid, modified gelatin and water by 1: 0.5: 1: 3 quality
Than mixing.
Described modified gelatin, is by 0.35 by normal saline that carboxymethyl chitosan, gelatin and concentration are 0.15%:
20min is stirred in 0.9: 3.5 mass ratio mixing, 60 DEG C of water bath with thermostatic control heating, and concentration is dried, and crosses 200 mesh sieves, you can.
The sow is comprised the following steps with immunostimulant preparation method：
(1) amino acid treatment：Lysine and L-Valine are weighed in proportion, 2 times of gross mass after mixing of water is added, plus
Thermal agitation, rises to after 70 DEG C to temperature, continues stirring, is concentrated into volume for 2/3 at 70 DEG C, is cooled to temperature for after 25 DEG C, plus
Enter 5 times of volume after concentrating of ethanol, extracting at constant temperature 15h, after ethanol is reclaimed in vacuum distillation, takes residual solution；
(2) dispensing：By the residual solution of step (1), gamma interferon, cytosine-guanine oligodeoxynucleotide, EGF epidermises
Cell growth factor, micro-powder of Chinese herbs are mixed in proportion, and obtain compound；
(3) microcapsule：After the normal saline that carboxymethyl chitosan, gelatin and concentration are 0.15% is mixed in proportion, stir
Mix after being heated to 80 DEG C, constant temperature stirs 15min, is coated in compound, with the frequency vibration 20min of 400 times/min, by spray
Mist dries and microcapsule is obtained.
The sow immunostimulant, takes in the morning and evening, each takes, immunostimulant is pressed with sow feed
0.3%：1 mass ratio mixing.
Embodiment 5
One broad sow immunostimulant, is made up of following raw material by weight：Gamma interferon 6g, cytosine-bird
Purine oligodeoxynucleotide 10g, EGF epithelical cell growth factor 9g, lysine 2.5g, L-Valine 2g, micro-powder of Chinese herbs 8g, micro- glue
Capsule coating 44g；
Micro-powder of Chinese herbs, is made up of following raw material by weight：Semen Vaccariae 15g, Pericarpium Citri Reticulatae Viride 6g, Medulla Tetrapanacis 12g, Herba Leonuri
3g, Radix Achyranthis Bidentatae 6g, Rhizoma Cyperi 10g.
Described micro-powder of Chinese herbs, be Chinese medicine is weighed in proportion after, dry to water content be 10%, crush, cross 80 mesh sieves,
By iron pan be heated to pot temperature for 90 DEG C when, by crushing after Chinese medicine powder be put in pot, stir-fry 15min, pulls out, is down to room temperature, i.e.,
Can.
Described microcapsule coating, be by cellulose acetate, alginic acid, modified gelatin and water by 1: 0.8: 1.5: 3 matter
Amount is than mixing.
Described modified gelatin, is by 0.2: 1.3 by normal saline that carboxymethyl chitosan, gelatin and concentration are 0.13%
: 3.5 mass ratio mixing, 65 DEG C of water bath with thermostatic control heating, 65min is stirred, concentration is dried, and crosses 300 mesh sieves, you can.
The sow is comprised the following steps with immunostimulant preparation method：
(1) amino acid treatment：Lysine and L-Valine are weighed in proportion, 1.5 times of gross mass after mixing of water is added,
Heated and stirred, rises to after 70 DEG C to temperature, continues stirring, is concentrated into volume for 2/3 at 70 DEG C, is cooled to temperature for after 30 DEG C,
5 times of volume after concentrating of ethanol, extracting at constant temperature 17h is added after ethanol is reclaimed in vacuum distillation, to take residual solution；
(2) dispensing：By the residual solution of step (1), gamma interferon, cytosine-guanine oligodeoxynucleotide, EGF epidermises
Cell growth factor, micro-powder of Chinese herbs are mixed in proportion, and obtain compound；
(3) microcapsule：After the normal saline that carboxymethyl chitosan, gelatin and concentration are 0.15% is mixed in proportion, stir
Mix after being heated to 80 DEG C, constant temperature stirs 15min, is coated in compound, with the frequency vibration 15min of 400 times/min, by spray
Mist dries and microcapsule is obtained.
The sow immunostimulant, takes in the morning and evening, each takes, immunostimulant is pressed with sow feed
0.4%: 1 mass ratio mixing.
Experimental example
1st, disease-free health, the sow 30 of the amixia that diet is good are chosen, are divided into two groups, conventinal breeding 6 months with
On, until sow starts to breed, breeding using in 24h twice with same boar natural mating, raise with rear single sow individual pen,
Feeding and management, routinely feeding and management code is carried out, and difference is, first group, is added using the present invention in feedstuff
The reinforcing agent of the preparation of embodiment 1～5, second group as a control group without, during suckling, free choice feeding, to sow and
Farrowing situation carries out observational study, as a result as shown in table 1：
Table 1
Explanation：Weight during sows farrowing is identical, and the daily ingestion amount of sow improves 10.31～14.1% relative to matched group.
Claims (7)
1. a broad sow immunostimulant, it is characterised in that be made up of following raw material by weight：Gamma interferon 4～
6th, cytosine-guanine oligodeoxynucleotide 10～15, EGF epithelical cell growth factors 6～9, lysine 2.5～3, L-Valine
1～2, micro-powder of Chinese herbs 7～9, microcapsule coating 31～44；
Micro-powder of Chinese herbs, is made up of following raw material by weight：Semen Vaccariae 10～15, Pericarpium Citri Reticulatae Viride 6～9, Medulla Tetrapanacis 8～12, Herba Leonuri
Grass 3～5, Radix Achyranthis Bidentatae 4～6, Rhizoma Cyperi 10～13.
2. sow immunostimulant as claimed in claim 1, it is characterised in that by following raw material group by weight
Into：Gamma interferon 5, cytosine-guanine oligodeoxynucleotide 13, EGF epithelical cell growth factors 8, lysine 2.8, figured silk fabrics ammonia
Acid 1.5, micro-powder of Chinese herbs 8, microcapsule coating 35.
3. sow immunostimulant as claimed in claim 1, it is characterised in that described micro-powder of Chinese herbs, be by Chinese medicine by
After ratio is weighed, it is 10～13% to dry to water content, crushes, crosses 80～100 mesh sieves, and iron pan is heated to pot temperature for 80～90
DEG C when, by crushing after Chinese medicine powder be put in pot, stir-fry 10～15min, pulls out, is down to room temperature, you can.
4. sow immunostimulant as claimed in claim 1, it is characterised in that described microcapsule coating, is by acetic acid
Cellulose, alginic acid, modified gelatin and water are mixed by 1: 0.5～0.8: 1～1.5: 3～4 mass ratio.
5. sow immunostimulant as claimed in claim 4, it is characterised in that described modified gelatin, is by carboxymethyl
Shitosan, gelatin and concentration be 0.11～0.15% normal saline by 0.2～0.35: 0.9～1.3: 3.5～4 mass ratio
15～20min is stirred in mixing, 60～70 DEG C of water bath with thermostatic control heating, and concentration is dried, and crosses 200～300 mesh sieves, you can.
6. sow immunostimulant as claimed in claim 1, it is characterised in that preparation method is comprised the following steps：
(1) amino acid treatment：Lysine and L-Valine are weighed in proportion, 1.5～2 times of gross mass after mixing of water is added,
Heated and stirred, rises to after 60～70 DEG C to temperature, continues stirring, and it is 2/3 to be concentrated into volume at 60～70 DEG C, and being cooled to temperature is
5 times of volume after concentrating of ethanol, 15～17h of extracting at constant temperature after 25～30 DEG C, is added after ethanol is reclaimed in vacuum distillation, to take residual
Extraction raffinate；
(2) dispensing：By the residual solution of step (1), gamma interferon, cytosine-guanine oligodeoxynucleotide, EGF epidermis cell
Somatomedin, micro-powder of Chinese herbs are mixed in proportion, and obtain compound；
(3) microcapsule：After the normal saline that carboxymethyl chitosan, gelatin and concentration are 0.11～0.15% is mixed in proportion,
After being heated with stirring to 80～90 DEG C, constant temperature stirs 15～20min, is coated in compound, with the frequency of 350～400 times/min
15～20min of vibration, is obtained microcapsule by being spray-dried.
7. sow immunostimulant as claimed in claim 1, it is characterised in that take in the morning and evening, each take, will
Immunostimulant is mixed by 0.3～0.4%: 1 mass ratio with sow feed.
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| CN108354060A (en) * | 2018-01-26 | 2018-08-03 | 佛山科学技术学院 | A kind of immunopotentiating agent promoting chicken H9N2 avian influenza vaccine immune effects |
| CN110178997A (en) * | 2019-06-20 | 2019-08-30 | 河南大陆农牧技术股份有限公司 | A kind of composition, nutrient fodder and its application improving the collaboration development of sow gestation phase placenta uterina umbilical cord |
| CN114601050A (en) * | 2022-03-17 | 2022-06-10 | 重庆市畜牧技术推广总站 | Sow feed additive for improving immunity of piglets and using method |
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| CN110178997A (en) * | 2019-06-20 | 2019-08-30 | 河南大陆农牧技术股份有限公司 | A kind of composition, nutrient fodder and its application improving the collaboration development of sow gestation phase placenta uterina umbilical cord |
| CN114601050A (en) * | 2022-03-17 | 2022-06-10 | 重庆市畜牧技术推广总站 | Sow feed additive for improving immunity of piglets and using method |
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