CN106491492A - A kind of screening flaw fibroin albumen composite aquogel and preparation method thereof - Google Patents
A kind of screening flaw fibroin albumen composite aquogel and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a kind of hide flaw fibroin albumen composite aquogel and preparation method thereof, it is made up of following components proportioning by weight：24～38 parts of fibroin, tussah silk protein 15～26 part, 15～28 parts of silk gum, 9～21 parts of Margarita powder extract, 6～19 parts of Rhizoma Atractylodis Macrocephalae extract, 5～19 parts of green-tea extract, 6～18 parts of Ramulus et Folium Mussaendae Pubescentis extract, 8～21 parts of vitamin C, 6～14 parts of Hydrolyzed Collagen, 3～7 parts of glycerine, 26～38 parts of deionized water.(1) screening flaw fibroin albumen composite aquogel of the present invention has smooth texture exquisiteness, good permeability, adhesive force strong, the advantage good to the regulating power of temperature change；(2) composite aquogel of the present invention has preferable holding effect to keratoderma moisture.
Description
Technical field
The invention belongs to cosmetic field, is related to a kind of cosmetics with silk as raw material, and in particular to a kind of screening flaw silk
Fibroin composite aquogel and preparation method thereof.
Background technology
Hydrogel is a kind of three-dimensional network macromolecular material with water as decentralized medium, insoluble do not melt, be wrapped in wherein
Substantial amounts of moisture.Three-dimensional porous network structure enables small-molecule substance diffusive migration in these framework spaces, and it can see
Into the concentrated solution for being polymer, elastomeric solid is may be considered again, have that some strength can keep form and softness has bullet
Property, its application is related to the fields such as biological medicine organizational project.Fibroin albumen is a kind of fibrous protein, steady with the heat which is good
The advantages of qualitative, excellent mechanical performance and biocompatibility, enjoys pass in the field such as organizational project wound healing and cell propagation
Note.
The three-dimensional net structure hydrogel that silk fibroin hydrogel is constituted as a kind of natural macromolecular material, with good
Biocompatibility, a large amount of water contents and highly cross-linked spacial framework, unique physicochemical property and to cell and small molecule
Permeability and diffusivity so as to the field such as breed in organizational project wound healing and cell and have broad application prospects.
At present, not yet to adopt hydrogel is prepared with fibroin albumen as primary raw material and be applied to skin hide flaw field.Existing skill
Base material of cosmetics can be used as using the coating powder particle material of silk gum in art, which has good water solubility, and can maintain water
Solution-stabilized, non-stimulated to skin, without allergy, and the coating powder gloss of this silk gum is moderate, visual effect is clearly transparent, can be good
Wrinkle, enlarged pores and other rough tissues of skin surface is covered well, good screening flaw effect is played.But, only with
Not smooth enough the fine and smooth, gas permeability of the quality of the coating powder of above-mentioned silk gum is not good, poor adhesive force, to the regulating power of temperature change compared with
Difference.
Content of the invention
Present invention solves the technical problem that：In order to overcome the defect of prior art, a kind of smooth texture is obtained fine and smooth, ventilative
Property good, adhesive force strong, the skin care item good to the regulating power of temperature change, the invention provides a kind of flaw fibroin albumen that hides is combined
Hydrogel and preparation method thereof.
Technical scheme：A kind of screening flaw fibroin albumen composite aquogel, is made up of following components proportioning by weight：Silk
Protein 24～38 part, tussah silk protein 15～26 part, 15～28 parts of silk gum, 9～21 parts of Margarita powder extract, Rhizoma Atractylodis Macrocephalae extract 6
～19 parts, 5～19 parts of green-tea extract, 6～18 parts of Ramulus et Folium Mussaendae Pubescentis extract, 8～21 parts of vitamin C, Hydrolyzed Collagen 6～14
Part, 3～7 parts of glycerine, 26～38 parts of deionized water.
Preferably, the screening flaw fibroin albumen composite aquogel is made up of following components proportioning by weight：Silk egg
White 30 parts, tussah silk 4 protein 22 part, 23 parts of silk gum, 16 parts of Margarita powder extract, 16 parts of Rhizoma Atractylodis Macrocephalae extract, green-tea extract 13
Part, 13 parts of Ramulus et Folium Mussaendae Pubescentis extract, 18 parts of vitamin C, 11 parts of Hydrolyzed Collagen, 5 parts of glycerine, 32 parts of deionized water.
A kind of preparation method for hiding flaw fibroin albumen composite aquogel, comprises the steps of：
(1) preparation of fibroin：Raw silk is placed in the sodium carbonate liquor that mass concentration is 0.55～0.82g/L,
Under the conditions of 83～100 DEG C, heat 35～54 minutes；After taking-up silk deionized water is rinsed well, then silk is put
In the sodium hydroxide solution that mass concentration is 0.12～0.32g/L, under the conditions of 86～100 DEG C, heat 12～20 points
Clock, takes out deionized water and cleans；
(2) preparation of tussah silk-fibroin：Raw tussah silk is placed in the sodium carbonate liquor that mass concentration is 1.4～1.9g/L
In, under the conditions of 92～100 DEG C, heat 20～45 minutes；After taking-up tussah silk deionized water is cleaned, then tussah silk is put
In the sodium hydroxide solution that mass concentration is 0.11～0.24g/L, heat 8～19 minutes under the conditions of 93～100 DEG C,
Take out deionized water to clean；
(3) prepared by composite aquogel precursor：The product of step (1) and step (2) is mixed, N- lauroyl is added thereto to
Sodium sarcosinate, addition for silk protein mixtures gross mass 3～8%, adds fibroin mixture gross mass 1.3～1.8
Deionized water again, 52～58 DEG C are reacted 14～23 minutes, are cooled to 4～7 DEG C and are reacted 21～45 minutes；
(4) hydrogel precursor is modified for the first time：To in hydrogel precursor obtained in step (3), add silk gum, pearl powder to carry
Thing, Rhizoma Atractylodis Macrocephalae extract, green-tea extract and Ramulus et Folium Mussaendae Pubescentis extract is taken, pH value is adjusted to 7.5～8.2, reacted 5～12 minutes；
(5) second modification of hydrogel precursor：Vitamin C and Hydrolyzed Collagen are added in the product of step (4), will
PH value is adjusted to 6.3～6.9, reacts 9～18 minutes；
(6) finished product：The product of step (5) is mixed with glycerine, pH value is adjusted to 7.0～7.4, is well mixed.
Preferably, the preparation of step (1) fibroin：Raw silk is placed in the sodium carbonate that mass concentration is 0.76g/L molten
In liquid, under the conditions of 93 DEG C, heat 46 minutes；After taking-up silk deionized water is rinsed well, then silk is placed in matter
During amount concentration is for the sodium hydroxide solution of 0.26g/L, heat 16 minutes under the conditions of 92 DEG C, taking-up is washed with deionized water
Only.
Preferably, the preparation of step (2) tussah silk-fibroin：Raw tussah silk is placed in the sodium carbonate that mass concentration is 1.6g/L
In solution, under the conditions of 96 DEG C, heat 38 minutes；After taking-up tussah silk deionized water is cleaned, then tussah silk is placed in matter
During amount concentration is for the sodium hydroxide solution of 0.18g/L, heat 16 minutes under the conditions of 97 DEG C, taking-up is washed with deionized water
Only.
Preferably, prepared by step (3) composite aquogel precursor：The product of step (1) and step (2) is mixed, thereto
N- sodium lauroyl sarcosines, addition for silk protein mixtures gross mass 6% is added to add fibroin mixture gross mass
1.6 times of deionized water, 55 DEG C are reacted 19 minutes, are cooled to 6 DEG C and are reacted 38 minutes.
Preferably, step (4) hydrogel precursor is modified for the first time：Silk is added in hydrogel precursor obtained in step (3)
PH value is adjusted to 7.9 by glue, Margarita powder extract, Rhizoma Atractylodis Macrocephalae extract, green-tea extract and Ramulus et Folium Mussaendae Pubescentis extract, is reacted 9 minutes.
Preferably, second modification of step (5) hydrogel precursor：Vitamin C and hydrolysis is added in the product of step (4)
PH value is adjusted to 6.6 by collagen, is reacted 13 minutes.
Preferably, step (6) finished product：The product of step (5) is mixed with glycerine, pH value is adjusted to 7.2, is well mixed.
Beneficial effect：(1) screening flaw fibroin albumen composite aquogel of the present invention has smooth texture exquisiteness, gas permeability
Good, adhesive force is strong, the advantage good to the regulating power of temperature change；(2) composite aquogel of the present invention is to keratoderma
Moisture has preferable holding effect.
Specific embodiment
Embodiment 1
A kind of screening flaw fibroin albumen composite aquogel, is made up of following components proportioning by weight：24 parts of fibroin,
Tussah silk protein 15 part, 15 parts of silk gum, 9 parts of Margarita powder extract, 6 parts of Rhizoma Atractylodis Macrocephalae extract, 5 parts of green-tea extract, white tea are extracted
6 parts of thing, 8 parts of vitamin C, 6 parts of Hydrolyzed Collagen, 3 parts of glycerine, 26 parts of deionized water.
A kind of preparation method for hiding flaw fibroin albumen composite aquogel, comprises the steps of：
(1) preparation of fibroin：Raw silk is placed in the sodium carbonate liquor that mass concentration is 0.55g/L, at 83 DEG C
Under the conditions of, heat 35 minutes；Take out after silk deionized water rinses well, then silk is placed in mass concentration and be
In the sodium hydroxide solution of 0.12g/L, heat 12 minutes under the conditions of 86 DEG C, take out deionized water and clean；
(2) preparation of tussah silk-fibroin：Raw tussah silk is placed in the sodium carbonate liquor that mass concentration is 1.4g/L, 92 DEG C
Under the conditions of, heat 20 minutes；Take out after tussah silk deionized water cleans, then tussah silk is placed in mass concentration and be
In the sodium hydroxide solution of 0.11g/L, heat 8 minutes under the conditions of 93 DEG C, take out deionized water and clean；
(3) prepared by composite aquogel precursor：The product of step (1) and step (2) is mixed, N- lauroyl is added thereto to
Sodium sarcosinate, addition for silk protein mixtures gross mass 3%, add 1.3 times of fibroin mixture gross mass go from
Sub- water, 52 DEG C are reacted 14 minutes, are cooled to 4 DEG C and are reacted 21 minutes；
(4) hydrogel precursor is modified for the first time：To in hydrogel precursor obtained in step (3), add silk gum, pearl powder to carry
Thing, Rhizoma Atractylodis Macrocephalae extract, green-tea extract and Ramulus et Folium Mussaendae Pubescentis extract is taken, pH value is adjusted to 7.5, reacted 5 minutes；
(5) second modification of hydrogel precursor：Vitamin C and Hydrolyzed Collagen are added in the product of step (4), will
PH value is adjusted to 6.3, reacts 9 minutes；
(6) finished product：The product of step (5) is mixed with glycerine, pH value is adjusted to 7.0, is well mixed.
Embodiment 2
A kind of screening flaw fibroin albumen composite aquogel, is made up of following components proportioning by weight：30 parts of fibroin,
Tussah silk 4 protein 22 part, 23 parts of silk gum, 16 parts of Margarita powder extract, 16 parts of Rhizoma Atractylodis Macrocephalae extract, 13 parts of green-tea extract, white tea are carried
Take 13 parts of thing, 18 parts of vitamin C, 11 parts of Hydrolyzed Collagen, 5 parts of glycerine, 32 parts of deionized water.
A kind of preparation method for hiding flaw fibroin albumen composite aquogel, comprises the steps of：
(1) preparation of fibroin：Raw silk is placed in the sodium carbonate liquor that mass concentration is 0.76g/L, at 93 DEG C
Under the conditions of, heat 46 minutes；Take out after silk deionized water rinses well, then silk is placed in mass concentration and be
In the sodium hydroxide solution of 0.26g/L, heat 16 minutes under the conditions of 92 DEG C, take out deionized water and clean；
(2) preparation of tussah silk-fibroin：Raw tussah silk is placed in the sodium carbonate liquor that mass concentration is 1.6g/L, 96 DEG C
Under the conditions of, heat 38 minutes；Take out after tussah silk deionized water cleans, then tussah silk is placed in mass concentration and be
In the sodium hydroxide solution of 0.18g/L, heat 16 minutes under the conditions of 97 DEG C, take out deionized water and clean；
(3) prepared by composite aquogel precursor：The product of step (1) and step (2) is mixed, N- lauroyl is added thereto to
Sodium sarcosinate, addition for silk protein mixtures gross mass 6%, add 1.6 times of fibroin mixture gross mass go from
Sub- water, 55 DEG C are reacted 19 minutes, are cooled to 6 DEG C and are reacted 38 minutes；
(4) hydrogel precursor is modified for the first time：To in hydrogel precursor obtained in step (3), add silk gum, pearl powder to carry
Thing, Rhizoma Atractylodis Macrocephalae extract, green-tea extract and Ramulus et Folium Mussaendae Pubescentis extract is taken, pH value is adjusted to 7.9, reacted 9 minutes；
(5) second modification of hydrogel precursor：Vitamin C and Hydrolyzed Collagen are added in the product of step (4), will
PH value is adjusted to 6.6, reacts 13 minutes；
(6) finished product：The product of step (5) is mixed with glycerine, pH value is adjusted to 7.2, is well mixed.
Embodiment 3
A kind of screening flaw fibroin albumen composite aquogel, is made up of following components proportioning by weight：38 parts of fibroin,
Tussah silk protein 26 part, 28 parts of silk gum, 21 parts of Margarita powder extract, 19 parts of Rhizoma Atractylodis Macrocephalae extract, 19 parts of green-tea extract, white tea are carried
Take 18 parts of thing, 21 parts of vitamin C, 14 parts of Hydrolyzed Collagen, 7 parts of glycerine, 38 parts of deionized water.
A kind of preparation method for hiding flaw fibroin albumen composite aquogel, comprises the steps of：
(1) preparation of fibroin：Raw silk is placed in the sodium carbonate liquor that mass concentration is 0.82g/L, at 100 DEG C
Under the conditions of, heat 54 minutes；Take out after silk deionized water rinses well, then silk is placed in mass concentration and be
In the sodium hydroxide solution of 0.32g/L, heat 20 minutes under the conditions of 100 DEG C, take out deionized water and clean；
(2) preparation of tussah silk-fibroin：Raw tussah silk is placed in the sodium carbonate liquor that mass concentration is 1.9g/L, 100
Under the conditions of DEG C, heat 45 minutes；Take out after tussah silk deionized water cleans, then tussah silk is placed in mass concentration and be
In the sodium hydroxide solution of 0.24g/L, heat 19 minutes under the conditions of 100 DEG C, take out deionized water and clean；
(3) prepared by composite aquogel precursor：The product of step (1) and step (2) is mixed, N- lauroyl is added thereto to
Sodium sarcosinate, addition for silk protein mixtures gross mass 8%, add 1.8 times of fibroin mixture gross mass go from
Sub- water, 58 DEG C are reacted 23 minutes, are cooled to 7 DEG C and are reacted 45 minutes；
(4) hydrogel precursor is modified for the first time：To in hydrogel precursor obtained in step (3), add silk gum, pearl powder to carry
Thing, Rhizoma Atractylodis Macrocephalae extract, green-tea extract and Ramulus et Folium Mussaendae Pubescentis extract is taken, pH value is adjusted to 8.2, reacted 12 minutes；
(5) second modification of hydrogel precursor：Vitamin C and Hydrolyzed Collagen are added in the product of step (4), will
PH value is adjusted to 6.9, reacts 18 minutes；
(6) finished product：The product of step (5) is mixed with glycerine, pH value is adjusted to 7.4, is well mixed.
The screening flaw fibroin albumen composite aquogel prepared by embodiment 1～3 is detected, as a result as shown in the table：
| Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| Gas permeability | Good | Good | Good |
| Adhesive force | Well | Good | Good |
Claims (9)
1. one kind hides flaw fibroin albumen composite aquogel, it is characterised in that be made up of following components proportioning by weight：Silk
Protein 24～38 part, tussah silk protein 15～26 part, 15～28 parts of silk gum, 9～21 parts of Margarita powder extract, Rhizoma Atractylodis Macrocephalae extract 6
～19 parts, 5～19 parts of green-tea extract, 6～18 parts of Ramulus et Folium Mussaendae Pubescentis extract, 8～21 parts of vitamin C, Hydrolyzed Collagen 6～14
Part, 3～7 parts of glycerine, 26～38 parts of deionized water.
2. one kind according to claim 1 hides flaw fibroin albumen composite aquogel, it is characterised in that by following components by weight
Amount number proportioning is made：30 parts of fibroin, tussah silk 4 protein 22 part, 23 parts of silk gum, 16 parts of Margarita powder extract, the bighead atractylodes rhizome are extracted
16 parts of thing, 13 parts of green-tea extract, 13 parts of Ramulus et Folium Mussaendae Pubescentis extract, 18 parts of vitamin C, 11 parts of Hydrolyzed Collagen, 5 parts of glycerine, go
32 parts of ionized water.
3. the preparation method of a kind of screening flaw fibroin albumen composite aquogel described in claim 1, it is characterised in that comprising following
Step：
(1) preparation of fibroin：Raw silk is placed in the sodium carbonate liquor that mass concentration is 0.55～0.82g/L, 83
Under the conditions of～100 DEG C, heat 35～54 minutes；After taking-up silk deionized water is rinsed well, then silk is placed in matter
Amount concentration is in the sodium hydroxide solution of 0.12～0.32g/L, heats 12～20 minutes, take under the conditions of 86～100 DEG C
Go out deionized water to clean；
(2) preparation of tussah silk-fibroin：Raw tussah silk is placed in the sodium carbonate liquor that mass concentration is 1.4～1.9g/L, 92
Under the conditions of～100 DEG C, heat 20～45 minutes；After taking-up tussah silk deionized water is cleaned, then tussah silk is placed in matter
Amount concentration is in the sodium hydroxide solution of 0.11～0.24g/L, heats 8～19 minutes under the conditions of 93～100 DEG C, takes out
Deionized water is cleaned；
(3) prepared by composite aquogel precursor：The product of step (1) and step (2) is mixed, N- lauroyl flesh ammonia is added thereto to
Sour sodium, addition for silk protein mixtures gross mass 3～8%, adds 1.3～1.8 times of fibroin mixture gross mass
Deionized water, 52～58 DEG C are reacted 14～23 minutes, are cooled to 4～7 DEG C and are reacted 21～45 minutes；
(4) hydrogel precursor is modified for the first time：To in hydrogel precursor obtained in step (3) add silk gum, Margarita powder extract,
PH value is adjusted to 7.5～8.2 by Rhizoma Atractylodis Macrocephalae extract, green-tea extract and Ramulus et Folium Mussaendae Pubescentis extract, is reacted 5～12 minutes；
(5) second modification of hydrogel precursor：Vitamin C and Hydrolyzed Collagen are added in the product of step (4), by pH value
6.3～6.9 are adjusted to, are reacted 9～18 minutes；
(6) finished product：The product of step (5) is mixed with glycerine, pH value is adjusted to 7.0～7.4, is well mixed.
4. according to claim 3 a kind of hide flaw fibroin albumen composite aquogel preparation method, it is characterised in that step
(1) preparation of fibroin：Raw silk is placed in the sodium carbonate liquor that mass concentration is 0.76g/L, under the conditions of 93 DEG C, plus
Heat treatment 46 minutes；After taking-up silk deionized water is rinsed well, then silk is placed in the hydrogen-oxygen that mass concentration is 0.26g/L
Change in sodium solution, heat 16 minutes under the conditions of 92 DEG C, take out deionized water and clean.
5. according to claim 3 a kind of hide flaw fibroin albumen composite aquogel preparation method, it is characterised in that step
(2) preparation of tussah silk-fibroin：Raw tussah silk is placed in the sodium carbonate liquor that mass concentration is 1.6g/L, under the conditions of 96 DEG C,
Heat 38 minutes；After taking-up tussah silk deionized water is cleaned, then tussah silk is placed in the hydrogen that mass concentration is 0.18g/L
In sodium hydroxide solution, heat 16 minutes under the conditions of 97 DEG C, take out deionized water and clean.
6. according to claim 3 a kind of hide flaw fibroin albumen composite aquogel preparation method, it is characterised in that step
(3) prepared by composite aquogel precursor：The product of step (1) and step (2) is mixed, N- Hamposyl Ls are added thereto to
Sodium, addition for silk protein mixtures gross mass 6%, the deionized water of 1.6 times of addition fibroin mixture gross mass, 55
DEG C reaction 19 minutes, be cooled to 6 DEG C react 38 minutes.
7. according to claim 3 a kind of hide flaw fibroin albumen composite aquogel preparation method, it is characterised in that step
(4) hydrogel precursor is modified for the first time：Silk gum, Margarita powder extract, the bighead atractylodes rhizome is added in hydrogel precursor obtained in step (3)
PH value is adjusted to 7.9 by extract, green-tea extract and Ramulus et Folium Mussaendae Pubescentis extract, is reacted 9 minutes.
8. according to claim 3 a kind of hide flaw fibroin albumen composite aquogel preparation method, it is characterised in that step
(5) second modification of hydrogel precursor：Vitamin C and Hydrolyzed Collagen are added in the product of step (4), pH value is adjusted to
6.6, react 13 minutes.
9. according to claim 3 a kind of hide flaw fibroin albumen composite aquogel preparation method, it is characterised in that step
(6) finished product：The product of step (5) is mixed with glycerine, pH value is adjusted to 7.2, is well mixed.
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| CN106943621A (en) * | 2017-04-21 | 2017-07-14 | 芜湖扬展新材料科技服务有限公司 | A kind of fibroin albumen composite biological tissues repair materials and preparation method thereof |
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| CN102895164A (en) * | 2012-09-25 | 2013-01-30 | 石磊 | Moisture mask and preparation method thereof |
| CN105902406A (en) * | 2016-05-27 | 2016-08-31 | 广州中科国典环境科技有限公司 | Composite protein peptide with skin care efficacy, hydrogel thereof and preparation method |
| CN106139257A (en) * | 2016-06-30 | 2016-11-23 | 南通纺织丝绸产业技术研究院 | A kind of orientation silk fibroin hydrogel and preparation method thereof |
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| CN106943621A (en) * | 2017-04-21 | 2017-07-14 | 芜湖扬展新材料科技服务有限公司 | A kind of fibroin albumen composite biological tissues repair materials and preparation method thereof |
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