CN106491385A - A kind of compositionss that repairs for skin barrier - Google Patents
A kind of compositionss that repairs for skin barrier Download PDFInfo
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- CN106491385A CN106491385A CN201611096953.8A CN201611096953A CN106491385A CN 106491385 A CN106491385 A CN 106491385A CN 201611096953 A CN201611096953 A CN 201611096953A CN 106491385 A CN106491385 A CN 106491385A
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- ceramide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Birds (AREA)
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- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
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- Cosmetics (AREA)
Abstract
The invention discloses a kind of for skin barrier repair compositionss, it is characterised in that its according to percentage by weight, including the following raw material：Squalane, Ah's glycerol, antioxidant, hexyldecanol base myristoyl first ammonia propanoic acid, ceramide, phytosphingosine, and other appropriate adjuvant.Present invention source is natural, and effect is good, has no side effect.Using with the natural ceramide of human body skin identical, Ah's glycerol, squalane; Tetraacetylphytospingosine, Vitamin E linoleate, the lipoid that simulates in real skin horny layer are constituted; can be penetrated to the skin deep layer, drastically increase the water humidity and barrier function of skin.Each component serves significant synergism, can greatly improve the effect for repairing skin barrier, and What is more, under certain special ratios, also there is obvious anti-wrinkle effect.
Description
Technical field
The present invention relates to a kind of compositionss that repairs for skin barrier, belong to cosmetic field.
Background technology
Dragons and fishes jumbled together for skin protection quality in the market, and some also have some violated things to add, and cause consumer skin occur
The impaired situation of skin horny layer is more and more, and some serious skin barrier problem even occur.
Skin barrier broad sense includes physical barriers, pigment barrier, nerve barrier, immunologic barrier.Narrow sense refers mainly to physical property
Barrier, what we said at ordinary times is all physical barriers.
Physical barrier is by sebum film, horny layer keratin, lipid, " sandwich " structure, brick wall structure, corium mucopolysaccharide
Class, mucopolysaccharide etc. are collectively formed, and are resisted extraneous harmful, stimulus object, daylight and are entered, while there is moisturizing and adjust antiinflammatory making
With.Physical skin barrier is impaired will to cause xerosis cutiss, skin aging, pigmentation atoipc dermatitis, eczema, psoriasises, fish
The skin greasings such as skin sensitivity, irritant dermatitis, the steroid-dependent dermatitis such as squama disease, solar dermatitis, seborrhea disease,
Such as acne, acne rosacea, seborrheic dermatitis.
Wherein, horny layer is " sandwich " structure, and " sandwich " structure is present in horny layer, and thickness is about 13nm, by
Up of three layers, ground floor and third layer are made up of crystalline lenses network, and centre is liquid phase, is made up of lipoid, mainly contains not
Satisfied fatty acid and cholesterol, due to the long-chain saturated hydrocarbon chain that there is a small amount of flowing, have near the lens structure of liquid phase slow
Slow mobility.In layer structure forming process, ceramide plays critically important effect with cholesterol, and in its transverse stack
In, be fatty acid in action, " sandwich " structure serves critically important effect in terms of cuticular moisturizing, protection.
There is scholar directly to detect keratodermatitis, to assess the situation of skin barrier.Norlen is from 20 women
Skin of chest isolates horny layer, and the phase is immersed in the distilled water of different temperatures, is seen using confocal laser scanning microscope, CLSM
Cuticular degrees of expansion is examined, is found through chlorine letter/methanol (2：1) extract the horny layer degrees of expansion after intercellular lipid to weaken.
Because the mechanism of horny layer expansion may be closely related with intercellular lipid structure, and the latter is formed with important work to skin barrier
With, therefore cuticular expansion behavior can also reflect the situation of skin barrier to a certain extent.Additionally, using adhesive tape sticking skin
Skin, the weight for determining adhesive tape institute adhesive material also be can yet be regarded as a kind of cuticular method of direct detection.The weight of adhesive tape institute adhesive material
Weight method is usually used to determine, with adhesive tape sticking number of times without linear relationship.But as experiment is wasted time and energy, for this purpose, marttin
It is directly proportional to cuticular weight based on the absorbing light of adhesive tape institute mucoprotein, establishes spectrophotometric analyses adhesive tape institute adhesive material
The method of weight.The method is simple compared with weight method, quick, but masks most of albumen due to the light that distributes of some materials on adhesive tape
Matter absorbing light and weaken the method reliability.Dreher quantitative determines the albumen in horny layer using improvement lowry method of testings
Matter, to be estimated to skin barrier.This method is more sensitive accurate compared with weight method, and favorable reproducibility.
Content of the invention
Based on the problem that the technical problem that background technology is present, the present invention are present for background technology, there is provided one kind is used for
The compositionss that skin barrier is repaired, which can repair skin barrier, effect is significant and natural safety.
The purpose of the present invention is achieved through the following technical solutions：
A kind of compositionss that repairs for skin barrier, it is characterised in that its according to percentage by weight, including following former
Material：
Squalane, (20-100%)
Ah's glycerol, (1-50%)
Antioxidant (0.01-5%)
Hexyldecanol base myristoyl first ammonia propanoic acid (0.2%-15%)
Ceramide (0.01-0.5%)
Phytosphingosine (0.01-0.5%)
And other appropriate adjuvant.
Preferably, the compositionss for skin barrier reparation include：
Squalane, (76.3%)
Ah's glycerol, (20%)
Lycopene (0.01-5%)
Hexyldecanol base myristoyl first ammonia propanoic acid, (1%)
Tocopherol linoleic acid fat (2%)
Ceramide 3 (0.1%)
Tetraacetylphytospingosine (0.1%)
And other appropriate adjuvant.
Lipoid in horny layer mainly includes ceramide, cholesterol and fatty acid, and the barrier function of skin is by horny layer
Intercellular lipoid thin layer is provided, and wherein ceramide plays pivotal role.Various ceramides contain phytosphingosine
Main chain, is connected with common, alpha-hydroxy fatty acid or Ω-hydroxy fatty acid by amine key.In skin, the content of ceramide is with year
Year, rapid development declined, and scaly dry skin explanation lacks the ceramide with phytosphingosine as main chain
What we were to be done is exactly that the lipoid for simulating human skin keratinocyte's layer is constituted, and reaches the effect of maintenance skin barrier.
We use and the natural ceramide of human body skin identical, Ah's glycerol, squalane, tetra-acetylated plant sheath ammonia
Alcohol, Vitamin E linoleate, the lipoid that simulates in real skin horny layer are constituted, and can penetrate to the skin deep layer, greatly
Improve the water humidity and barrier function of skin.
Lycopene is contained a kind of natural pigment in plant.It is primarily present in the mature fruit of plant of Solanaceae Fructus Lycopersici esculenti
In.It is most one of the powerful antioxidant being found in the plant of nature at present.Science proves, the singlet oxygen in human body
It is the arch-criminal of infringement human body self immune system with oxygen-derived free radicals.Lycopene is removed effect of free radical and outclass which
His carotenoid and vitamin E, its singlet-oxygen quenching speed constant is 100 times of vitamin E.It can be with effectively preventing
Because of aging, the various diseases that immunity degradation causes.Therefore, it is paid close attention to by countries in the world expert.Lycopene is inhaled respectively
UVB and UVA is received, therefore can be cashed as colourless.When them are irradiated with sunlight or ultraviolet light (UV), they can send green
Fluorescence.Color antagonism theory be by form and aspect eliminate experiment set up, in this experiment experimenter as indicated, adjustment HONGGUANG and
The ratio of green glow, until acquisition one neither redness is nor till the color of green.In this case, it will usually occur
Yellow (it should be noted that not being red green).Likewise, both can also be obtained by the ratio of adjustment blueness and sodium yellow
It is not blueness nor another color of yellow.
Lack necessary fat acid to take in linoleic acid by multi-form to improve in human body skin, research shows sub- oil
Acid esters plays an important role in water loss and the Maintenance Of Skin Health is prevented, and linoleic acid take part in the moisturizing process of skin, it
Excessive water loss is prevented, especially for skin ambustion.
1987, WEISER and ERLEMANN in the article that German perfume and cosmetics magazine are delivered proposed one and controls
Model is treated, the process of superficial skin wound healing is studied.They compare linoleic acid ester of vitamin e and placebo effect, draw knot
By:Linoleic acid ester of vitamin e can accelerate the recovery of wound.Prevent unsaturated fatty acid oxidized, it effectively can slow down
Aging, resists burning for sunlight.
The present inventor is found surprisingly that, adds the tomato red of special ratio in the lipoid of simulation human skin keratinocyte's layer
Element, coordinates the optimization of integral formula, finds surprising effect：The effect for repairing skin barrier can be greatly improved, is more had
Notably, under certain special ratios, also there is obvious anti-wrinkle effect.
The invention has benefit that：
1) present invention source is natural, and effect is good, has no side effect.
2) present invention is used and the natural ceramide of human body skin identical, Ah's glycerol, squalane, tetra-acetylated plant sheath
Ammonia alcohol, Vitamin E linoleate, the lipoid that simulates in real skin horny layer are constituted, and can penetrate to the skin deep layer, greatly
Improve the water humidity and barrier function of skin.
3) skin care item of lycopene have the effect for instantaneously taking off glow skin.
4) each component serves significant synergism, can greatly improve the effect for repairing skin barrier, and What is more,
Under certain special ratios, also there is obvious anti-wrinkle effect.
Description of the drawings
Fig. 1-2 is the change using skin color after the present composition.
Specific embodiment
Embodiment 1：
A kind of for skin barrier repair compositionss, it is characterised in that its according to parts by weight, including the following raw material：
Squalane, (60 parts)
Ah's glycerol, (20 parts)
Lycopene (5 parts)
Hexyldecanol base myristoyl first ammonia propanoic acid, (1 part)
Ceramide 3 (0.05 part)
Tetraacetylphytospingosine (0.01 part)
And other 100 parts appropriate of adjuvant.
By the metering mixing of above-mentioned each component, more than 90 degree dissolving ceramides and phytosphingosine is heated to, is sufficiently stirred for
Mixing is obtained final product.
Embodiment 2：
A kind of for skin barrier repair compositionss, it is characterised in that its according to parts by weight, including the following raw material：
Squalane, (80 parts)
Ah's glycerol, (20 parts)
Lycopene (0.01 part)
Hexyldecanol base myristoyl first ammonia propanoic acid, (2 parts)
Ceramide 3 (0.1 part)
Tetraacetylphytospingosine (0.01 part)
And other 100 parts appropriate of adjuvant.
By the metering mixing of above-mentioned each component, more than 90 degree dissolving ceramides and phytosphingosine is heated to, is sufficiently stirred for
Mixing is obtained final product.
Embodiment 3：
A kind of for skin barrier repair compositionss, it is characterised in that its according to parts by weight, including the following raw material：
Squalane, (70 parts)
Ah's glycerol, (20 parts)
Lycopene (4 parts)
Hexyldecanol base myristoyl first ammonia propanoic acid, (2 parts)
Ceramide 3 (0.05 part)
Tetraacetylphytospingosine (0.02 part)
And other 100 parts appropriate of adjuvant.
By the metering mixing of above-mentioned each component, more than 90 degree dissolving ceramides and phytosphingosine is heated to, is sufficiently stirred for
Mixing is obtained final product.
Embodiment 4：
A kind of for skin barrier repair compositionss, it is characterised in that its according to parts by weight, including the following raw material：
Squalane, (61 parts)
Ah's glycerol, (20 parts)
Lycopene (0.02 part)
Hexyldecanol base myristoyl first ammonia propanoic acid, (3 parts)
Tocopherol linoleic acid fat (2 parts)
Ceramide 3 (0.02 part)
Tetraacetylphytospingosine (0.02 part)
And other 100 parts appropriate of adjuvant.
By the metering mixing of above-mentioned each component, more than 90 degree dissolving ceramides and phytosphingosine is heated to, is sufficiently stirred for
Mixing is obtained final product.
Embodiment 5：
A kind of for skin barrier repair compositionss, it is characterised in that its according to parts by weight, including the following raw material：
Squalane, (76.3 parts)
Ah's glycerol, (20 parts)
Lycopene (0.01-5 parts)
Hexyldecanol base myristoyl first ammonia propanoic acid, (1 part)
Tocopherol linoleic acid fat (2 parts)
Ceramide 3 (0.1 part)
Tetraacetylphytospingosine (0.01 part)
And other 100 parts appropriate of adjuvant.
By the metering mixing of above-mentioned each component, more than 90 degree dissolving ceramides and phytosphingosine is heated to, is sufficiently stirred for
Mixing is obtained final product.
6 horny layer repairing effect of embodiment is tested and assessed：
The compositionss of the present invention can be effectively improved the barrier function with contact dermatitis skin and clinical setting.
Test man's number:175, it is divided into 7, per group of 25 people, between each group, there was no significant difference.
The formula that matched group 1 is used is following (without lycopene)：
Squalane, (79 parts)
Ah's glycerol, (20 parts)
Lycopene (3 parts)
Hexyldecanol base myristoyl first ammonia propanoic acid, (1 part)
Ceramide 3 (0.1 part)
Tetraacetylphytospingosine (0.1 part)
Other 100 parts appropriate of adjuvant.
The formula that matched group 2 is used is following (only using lycopene)：
Lycopene (3 parts)
Other 100 parts appropriate of adjuvant.
Product:Using the compositionss of embodiment 1-5, and matched group is tested.
Usage frequency:Daily 1-2 time, each 3g most long uses 8 weeks.
Symptoms Assessment:By dermatologist using front, when 4 weeks and 8 weeks, stochastic appraisal is carried out.
Symptom feature:Dry, decortication, erythema, trace oxygen, the order of severity of cracking and totality.
Index grading:0=without；1=is lighter；2=is medium；3=is serious.
As a result as shown in following table 1-2.
Table 1
Table 2
Result of the test shows：The compositionss of the present invention can be effectively improved the barrier function with contact dermatitis skin, kind
Significant synergism is served between lycopene and other formula.
7 anti-wrinkle effect of embodiment：
Test man's number:125, it is divided into 5, per group of 25 people, between each group, there was no significant difference, and the age is between 38-45 year.
Method of testing：Forearm uses the present composition, with image analytical method at skin pull (silica replica)
Upper measurement wrinkle depth, records original state.
Impact result after 30 days to deep wrinkles is as shown in table 3：
Table 3
| Deep wrinkles (100 μm of ＞) change after 30 days | |
| Embodiment 1 | Reduce 0.3% |
| Embodiment 2 | Reduce 0.2% |
| Embodiment 3 | Reduce 0.2% |
| Embodiment 4 | Reduce 0.3% |
| Embodiment 5 | Reduce 6.1% |
It can be seen that, the formula of embodiment 5 is unforeseeable with the effect for significantly improving deep wrinkles, and other formula are then not
Substantially, concrete reason need further to study.
8 moment of embodiment moves back red effect：
Lycopene absorbs UVB and UVA respectively, therefore can cash as colourless.When being irradiated with sunlight or ultraviolet light (UV)
They when, they can send green fluorescence.
Color antagonism theory is to eliminate experiment by form and aspect to set up, and experimenter as indicated, adjusts red in this experiment
Light and the ratio of green glow, until acquisition one neither redness is nor till the color of green.In this case, it will usually
There is yellow (it should be noted that not being red green).Likewise, can also be obtained by the ratio of adjustment blueness and sodium yellow
Neither blueness nor another color of yellow.
Experimental design：
Instant effect：It is estimated using effect for instantaneously taking off glow skin of the skin care item containing 1.5% lycopene.
N=4 (volunteer of 2 skin rubefaction, the volunteer of 2 normal skin tones)；
Half face is tested；Compareed with placebo；After once, it is exposed under the light of full spectrum, then passes through color
Measuring system is tested and analyzed.
As a result as shown in accompanying drawing 1-2.As seen from the figure, compositionss of the invention have the good effect for moving back red bright color
Really.
As can be seen here, present invention source is natural, and effect is good, has no side effect.Using with the natural nerve of human body skin identical
Amide, Ah's glycerol, squalane, Tetraacetylphytospingosine come simulate the lipoid in real skin horny layer composition, can ooze
Thoroughly to deep skin, the water humidity and barrier function of skin is drastically increased.Each component serves significant synergism, can
To greatly improve the effect for repairing skin barrier, What is more, under certain special ratios, also there is obvious anti-wrinkle effect.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
Any those familiar with the art the invention discloses technical scope in, technology according to the present invention scheme and its
Inventive concept equivalent or change in addition, should all be included within the scope of the present invention.
Claims (6)
1. a kind of for skin barrier repair compositionss, it is characterised in that its according to percentage by weight, including the following raw material：
Squalane, (20-100%)
Ah's glycerol, (1-50%)
Antioxidant (0.01-5%)
Hexyldecanol base myristoyl first ammonia propanoic acid (0.2%-15%)
Ceramide (0.01-0.5%)
Phytosphingosine (0.01-0.5%)
And other appropriate adjuvant.
2. compositionss described in claim 1, it is characterised in that：
Preferably, the compositionss for skin barrier reparation include：
Squalane, (76.3%)
Ah's glycerol, (20%)
Lycopene (0.01-5%)
Hexyldecanol base myristoyl first ammonia propanoic acid, (1%)
Ceramide 3 (0.1%)
Tetraacetylphytospingosine (0.1%)
And other appropriate adjuvant, by the metering mixing of above-mentioned each component, it is heated to more than 90 degree dissolving ceramides and plant
Sphingol, is sufficiently stirred for mixing and obtains final product.
3. application of the compositionss described in claim 1 or 2 on the cosmetics for preparing skin barrier reparation.
4. the application described in claim 3, it include being prepared into emulsion, curry, elite, facial film or frost.
5. application of the compositionss described in claim 2 on anti-aging cosmetics are prepared.
6. the application described in claim 5, it include being prepared into emulsion, curry, elite or frost.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611096953.8A CN106491385A (en) | 2016-12-02 | 2016-12-02 | A kind of compositionss that repairs for skin barrier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611096953.8A CN106491385A (en) | 2016-12-02 | 2016-12-02 | A kind of compositionss that repairs for skin barrier |
Publications (1)
| Publication Number | Publication Date |
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| CN106491385A true CN106491385A (en) | 2017-03-15 |
Family
ID=58330458
Family Applications (1)
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| CN201611096953.8A Pending CN106491385A (en) | 2016-12-02 | 2016-12-02 | A kind of compositionss that repairs for skin barrier |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846757A (en) * | 2019-02-15 | 2019-06-07 | 广州环亚化妆品科技有限公司 | A kind of bionical composition of sebum and the cosmetics comprising it |
| CN111544643A (en) * | 2020-04-23 | 2020-08-18 | 海南芬森医疗器械有限公司 | Gamma-polyglutamic acid skin barrier repair dressing and preparation method thereof |
| CN115947666A (en) * | 2023-02-02 | 2023-04-11 | 深圳市迪克曼生物科技有限公司 | Rice bran oil ceramide and synthesis method and application thereof |
| CN116370345A (en) * | 2023-04-23 | 2023-07-04 | 重庆智合生物医药有限公司 | Transparent oil solution containing ceramide and sphingosine and preparation method thereof |
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| CN104814917A (en) * | 2015-04-24 | 2015-08-05 | 新疆西域果宝生物科技有限公司 | Cosmetic composition |
| CN105687038A (en) * | 2016-03-05 | 2016-06-22 | 广州丹奇日用化工厂有限公司 | Skin-care makeup remover cream with skin surface lipid film repairing function and preparation method of skin-care makeup remover cream |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104814917A (en) * | 2015-04-24 | 2015-08-05 | 新疆西域果宝生物科技有限公司 | Cosmetic composition |
| CN105687038A (en) * | 2016-03-05 | 2016-06-22 | 广州丹奇日用化工厂有限公司 | Skin-care makeup remover cream with skin surface lipid film repairing function and preparation method of skin-care makeup remover cream |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846757A (en) * | 2019-02-15 | 2019-06-07 | 广州环亚化妆品科技有限公司 | A kind of bionical composition of sebum and the cosmetics comprising it |
| CN111544643A (en) * | 2020-04-23 | 2020-08-18 | 海南芬森医疗器械有限公司 | Gamma-polyglutamic acid skin barrier repair dressing and preparation method thereof |
| CN115947666A (en) * | 2023-02-02 | 2023-04-11 | 深圳市迪克曼生物科技有限公司 | Rice bran oil ceramide and synthesis method and application thereof |
| CN116370345A (en) * | 2023-04-23 | 2023-07-04 | 重庆智合生物医药有限公司 | Transparent oil solution containing ceramide and sphingosine and preparation method thereof |
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